CN112386717A - Disposable blood virus inactivating device - Google Patents
Disposable blood virus inactivating device Download PDFInfo
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- CN112386717A CN112386717A CN202011460308.6A CN202011460308A CN112386717A CN 112386717 A CN112386717 A CN 112386717A CN 202011460308 A CN202011460308 A CN 202011460308A CN 112386717 A CN112386717 A CN 112386717A
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- side wall
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- 210000004369 blood Anatomy 0.000 title claims abstract description 95
- 239000008280 blood Substances 0.000 title claims abstract description 95
- 241000700605 Viruses Species 0.000 title claims abstract description 53
- 230000000415 inactivating effect Effects 0.000 title claims description 13
- 239000007788 liquid Substances 0.000 claims abstract description 47
- 238000001914 filtration Methods 0.000 claims abstract description 41
- 230000002779 inactivation Effects 0.000 claims abstract description 35
- 230000000937 inactivator Effects 0.000 claims abstract description 16
- 238000007789 sealing Methods 0.000 claims description 41
- 238000005192 partition Methods 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 24
- 230000000670 limiting effect Effects 0.000 claims description 23
- 230000006835 compression Effects 0.000 claims description 21
- 238000007906 compression Methods 0.000 claims description 21
- 230000005540 biological transmission Effects 0.000 claims description 16
- 238000005286 illumination Methods 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 6
- 239000003504 photosensitizing agent Substances 0.000 claims description 4
- 230000005484 gravity Effects 0.000 claims description 3
- 238000006552 photochemical reaction Methods 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 230000002829 reductive effect Effects 0.000 abstract description 2
- 230000003612 virological effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/088—Radiation using a photocatalyst or photosensitiser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/02—Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a disposable blood virus inactivation device, which relates to the technical field of medical instruments and comprises a blood storage bag, a bag inserting needle and a first catheter; the lower end of the first conduit is fixedly connected with a bag inserting needle, and the end head of the bag inserting needle is inserted into the liquid inlet end of the blood storage bag; it also comprises a filtering mechanism and a photochemical inactivation mechanism; the upper end of a pipe is connected with filtering mechanism, and No. two pipes of fixedly connected with are gone up to filtering mechanism's inlet, and the loaded down with trivial details nature that medical personnel operated can be reduced to the upper end of No. two pipes and the output end fixed connection of photochemistry inactivation mechanism, simultaneously, can conveniently add the inactivator, has improved the efficiency of viral inactivation.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a disposable blood virus inactivation device.
Background
The blood or blood components for clinical transfusion are composed of various cells and molecules with different activities, and component transfusion by single or basically similar function blood cells has gradually replaced whole blood transfusion in clinical transfusion, thus not only meeting the increasing blood source requirement, but also having very important significance for improving transfusion quality and reducing adverse reactions caused by transfusion.
The leucocyte transfusion in the blood component that the donor donated is harmful, it not only carries a large amount of virus of affinity leucocyte such as hepatitis virus, cytomegalovirus, AIDS virus etc., so need to carry out virus inactivation to blood and handle, need to use virus inactivation device to handle in order to inactivate these viruses, but the virus inactivation device among the prior art all is used repeatedly, medical personnel are troublesome to the device disinfection operation after the inactivation, influence the efficiency of virus inactivation, it is more loaded down with trivial details to add inactivator operation simultaneously, consequently, need a disposable blood virus inactivation device urgently.
Disclosure of Invention
Aiming at the defects and shortcomings of the prior art, the invention provides the disposable blood virus inactivation device which is simple in structure, reasonable in design and convenient to use, can reduce the complexity of the operation of medical personnel, can conveniently add an inactivating agent, and improves the virus inactivation efficiency.
In order to achieve the purpose, the invention adopts the technical scheme that: it comprises a blood storage bag, a bag inserting needle and a first catheter; the lower end of the first conduit is fixedly connected with a bag inserting needle, and the end head of the bag inserting needle is inserted into the liquid inlet end of the blood storage bag; it also comprises a filtering mechanism and a photochemical inactivation mechanism; the upper end of the first conduit is connected with a filtering mechanism, the inlet end of the filtering mechanism is fixedly connected with a second conduit, and the upper end of the second conduit is fixedly connected with the output end of the photochemical inactivation mechanism;
the filtering mechanism comprises an upper sealing cover, a lower sealing cover, a shell, a first filtering layer and a second filtering layer; the shell is of a hollow structure with openings at the upper end and the lower end, an upper sealing cover is rotatably sleeved on the opening end at the upper side of the shell through threads, and a lower sealing cover is arranged on the opening end at the lower side of the shell through a threaded rotating sleeve; a liquid inlet is formed in the middle of the upper sealing cover, the top surface of the upper sealing cover is fixedly connected with the lower end of the second guide pipe, and the second guide pipe is communicated with the inside of the liquid inlet; a first filter layer and a second filter layer are sequentially arranged inside the shell from inside to outside, the liquid inlet is communicated with the middle part of the first filter layer, the liquid outlet is formed inside the lower sealing cover, the liquid outlet is communicated with a gap between the second filter layer and the inner side wall of the shell, the upper end of the first guide pipe is fixedly connected with the bottom surface of the lower sealing cover, and the first guide pipe is communicated with the inside of the liquid outlet;
the photochemical inactivation mechanism comprises a box body, a partition plate, a pressure rod, a push plate, an external threaded pipe and a tension spring; the upper end of the first guide pipe is fixedly arranged on the left side of the bottom surface of the box body, the first guide pipe is communicated with the interior of the box body, and the box body is arranged in a transparent manner; a liquid inlet pipe is fixedly arranged on the bottom surface of the box body on the right side of the first guide pipe and communicated with the inside of the box body; a partition board is fixedly arranged on the upper side inside the box body, and a shading layer is fixedly arranged on the outer side wall of the box body on the upper side of the partition board; a pressing plate is movably arranged in the box body on the upper side of the partition plate, a plurality of pressing blocks are fixedly arranged on the bottom surface of the pressing plate at equal intervals, a plurality of through holes are correspondingly formed in the partition plate, diaphragms are fixedly arranged in the through holes, and the thickness of each pressing block is the same as the depth of each through hole; a virus inactivating agent is filled in a cavity inside the box body between the pressing plate and the partition plate; a pressure rod is vertically and fixedly arranged on the top surface of the pressure plate, the upper end of the pressure rod is movably inserted on the top surface of the box body through a sealed linear bearing, a hand-held block is fixedly arranged on the upper end head of the pressure rod, a tension spring is sleeved on the pressure rod between the top surface of the pressure plate and the inner top surface of the box body, the upper end of the tension spring is fixedly connected with the inner top surface of the box body, and the lower end of the tension spring is fixedly connected with the top surface of the; the inside push pedal that is provided with of baffle downside box body, the left side wall parallel arrangement of push pedal and box body, be provided with the external screw thread pipe through bearing vertical rotation on the right side wall of push pedal, the right-hand member of external screw thread pipe passes behind the right side wall of box body through the screw rotation, stretches to establish on the right side of box body, and stretches to establish and serve the fixed hand of being provided with and twist.
Furthermore, a transmission rod is movably arranged in the outer threaded pipe in a penetrating mode through a sealed linear bearing, the right end of the rotating rod extends to the right side of the hand screw after passing through the hand screw, a limiting block is fixedly arranged on the extending end, a compression spring is sleeved on the transmission rod between the limiting block and the hand screw, the right end of the compression spring is fixedly connected with the limiting block, and the left end of the compression spring is fixedly connected with the right side wall of the hand screw; a placing groove is formed in the left side wall of the push plate, the left end of the transmission rod extends into the placing groove, a plurality of stirring blades are fixedly arranged on the extending end at equal fillets, and the stirring blades are movably embedded into the placing groove; when the virus inactivating agent is mixed with the blood in the box body, the left end of the transmission rod drives the stirring blade to leave the placing groove and stretch into the blood by pressing the limiting block, the compression spring is in a compression state at the moment, and then the limiting block is rotated to enable the stirring blade to rotate and stir in the blood, so that the virus inactivating agent is more uniformly mixed with the blood, and meanwhile, the blood is more uniformly contacted with the external light; when the stirring is finished, the limiting block is loosened, and the limiting block is pushed rightwards by the reverse compression force of the compression spring, so that the stirring blade is restored to be embedded in the accommodating groove.
Furthermore, elastic washers are fixedly sleeved on the peripheral walls of the pressing plate and the push plate, the outer side walls of the elastic washers on the periphery of the pressing plate are abutted to the peripheral walls inside the box body, the upper side surface of the elastic washer on the outer side of the push plate is abutted to the bottom surface of the partition plate, and the front side wall, the rear side wall and the lower side wall of the elastic washer on the outer side of the push plate are abutted to the inner side wall of the box body; the connection parts of the pressing plate, the push plate and the inner side wall of the box body are sealed through the elastic sealing performance of the elastic gasket.
Furthermore, a sealing gasket is fixedly arranged on the outer side wall of the pressing block; when the pressing block is embedded in the through hole, the sealing gasket increases the sealing property of the connection between the pressing block and the through hole.
Furthermore, a spherical groove is formed in a lower port of the liquid inlet in a penetrating manner, steel balls are movably arranged in a cavity in the first filter layer, and the diameter of each steel ball is matched with that of the spherical groove; when medical personnel invert the inside filtrations of casing and rock, the steel ball is inlayed in the inside of spherical groove owing to the action of gravity, prevents that the inside filtrating of casing from entering into the inside of No. two pipes once more.
Furthermore, a hanging ring is fixedly arranged on the rear side wall of the box body; when the illumination reaction is carried out, the whole device is hung in the illumination machine through the hanging ring.
The working principle of the invention is as follows: blood to be subjected to virus inactivation is conveyed to the interior of the box body on the lower side of the partition plate through the liquid inlet pipe, the interior of the box body on the lower side of the partition plate is in a negative pressure state before liquid is fed, and the push plate is positioned on the rightmost side of the box body; after liquid feeding is finished, the bag inserting needle is connected with the blood storage bag, then the pressing plate is pressed down through the handheld block, the pressing plate presses the pressure of the virus inactivating agent to break the diaphragm, the virus inactivating agent enters the blood on the lower side of the partition plate through the through hole to be contacted with the blood, then the box body is placed in an illumination machine to perform illumination reaction, and the virus inactivating agent and light generate photochemical reaction to inactivate viruses in the blood; after the reaction is finished, the blood enters the interior of the filtering mechanism through the second conduit and the liquid inlet, and after the blood sequentially passes through the first filtering layer and the second filtering layer, the blood enters the interior of the first conduit from the liquid outlet and finally enters the interior of the blood storage bag for storage; the first filter layer and the second filter layer filter the photosensitizer and the white blood cells in the virus inactivator in the blood; blood is when entering into the inside of blood storage bag, twists through the hand and rotates the external screw thread pipe, and the push pedal slowly moves left, presses the clamp plate this moment for the briquetting blocks up in the inside of through-hole, and the push pedal is constantly extruded blood and is entered into filtering mechanism's inside from No. two pipes.
After adopting the structure, the invention has the beneficial effects that:
1. the diaphragm arranged in the photochemical inactivation mechanism is damaged by extrusion of the virus extinguishing agent and then is contacted with blood, so that the operation is more convenient;
2. the push plate continuously extrudes the blood from the second catheter to the inside of the filtering mechanism, so that the filtering efficiency is improved, and meanwhile, the blood in the box body is more completely conveyed to the inside of the blood storage bag;
3. the first filter layer and the second filter layer in the filter mechanism adopt annular structures, so that the contact area of blood and the first filter layer is increased, and the filter efficiency is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic view of the internal structure of the present invention.
Fig. 3 is an enlarged view of a portion a in fig. 2.
Fig. 4 is an enlarged view of a portion B in fig. 2.
Fig. 5 is a sectional view of the housing, filter layer one and filter layer two of the present invention.
Description of reference numerals:
the blood storage bag comprises a first catheter 1, a bag inserting needle 2, a blood storage bag 3, a second catheter 4, a filtering mechanism 5, an upper sealing cover 5-1, a lower sealing cover 5-2, a shell 5-3, a first filtering layer 5-4, a second filtering layer 5-5, a liquid inlet 5-6, a liquid outlet 5-7, a photochemical inactivation mechanism 6, a box body 6-1, a liquid inlet pipe 6-2, a partition plate 6-3, a shading layer 6-4, a pressing plate 6-5, a pressing block 6-6, a through hole 6-7, a diaphragm 6-8, a virus inactivating agent 6-9, a pressing rod 6-10, a handheld block 6-11, a tension spring 6-12, a pushing plate 6-13, an external threaded pipe 6-14, a hand screw 6-15, a transmission rod 7, a limiting block 8, a compression spring 9, a resting groove 10, a stirring blade 11, a stirring, The elastic washer 12, the sealing gasket 13, the spherical groove 14, the steel ball 15 and the suspension ring 16.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
Referring to fig. 1 to 5, the technical solution adopted by the present embodiment is: it comprises a blood storage bag 3, a bag inserting needle 2 and a first catheter 1; the internal structure of the whole device is made of medical grade materials; the lower end of the first catheter 1 is fixedly connected with a bag inserting needle 2 through gluing, the end head of the bag inserting needle 2 is inserted into the liquid inlet end of a blood storage bag 3, and the structure and the principle of the blood storage bag 3 are the same as those of a blood transfusion bag in the prior art; it also comprises a filtering mechanism 5 and a photochemical inactivation mechanism 6; the upper end of the first conduit 1 is connected with a filtering mechanism 5, the inlet end of the filtering mechanism 5 is fixedly connected with a second conduit 4, and the upper end of the second conduit 4 is fixedly connected with the output end of the photochemical inactivation mechanism 6;
the filtering mechanism 5 comprises an upper sealing cover 5-1, a lower sealing cover 5-2, a shell 5-3, a first filtering layer 5-4 and a second filtering layer 5-5; the shell 5-3 is a hollow structure with openings at the upper end and the lower end, an upper sealing cover 5-1 is rotatably sleeved on the opening end at the upper side of the shell 5-3 through threads, and a lower sealing cover 5-2 is arranged on the opening end at the lower side of the shell 5-3 through a threaded rotating sleeve; the middle part of the upper sealing cover 5-1 is provided with a liquid inlet 5-6, the top surface of the upper sealing cover 5-1 is fixedly connected with the lower end of the second conduit 4, and the second conduit 4 is communicated with the inside of the liquid inlet 5-6; a first filter layer 5-4 and a second filter layer 5-5 are sequentially arranged inside the shell 5-3 from inside to outside, the first filter layer 5-4 and the second filter layer 5-5 are coaxially and annularly arranged, the upper side surface and the lower side surface of the first filter layer 5-4 and the second filter layer 5-5 are respectively and fixedly connected with the upper sealing cover 5-1 and the lower sealing cover 5-2 in a sealing way, the liquid inlet 5-6 is communicated with the middle part of the first filter layer 5-4, the lower sealing cover 5-2 is internally provided with a liquid outlet 5-7, the liquid outlet 5-7 is communicated with a gap between the second filter layer 5-5 and the inner side wall of the shell 5-3, the upper end of the first guide pipe 1 is fixedly connected with the bottom surface of the lower sealing cover 5-2, and the first guide pipe 1 is communicated with the inside; a spherical groove 14 is formed in the lower port of the liquid inlet 5-6 in a penetrating manner, steel balls 15 are movably arranged in a cavity inside the first filter layer 5-4, and the diameter of each steel ball 15 is matched with that of the spherical groove 14; when the medical staff invert and shake the filtrate in the shell 5-3, the steel ball 15 is embedded in the spherical groove 14 due to the action of gravity, so that the filtrate in the shell 5-3 is prevented from entering the second conduit 4 again;
the photochemical inactivation mechanism 6 comprises a box body 6-1, a partition plate 6-3, a pressure plate 6-5, a pressure rod 6-10, a push plate 6-13, an external threaded pipe 6-14 and a tension spring 6-12; the upper end of the first conduit 1 is fixedly arranged on the left side of the bottom surface of the box body 6-1, the first conduit 1 is communicated with the interior of the box body 6-1, and the box body 6-1 is transparent, so that the illumination device 6-1 is conveniently arranged in a cuboid shape; a hanging ring 16 is fixedly arranged on the rear side wall of the box body 6-1 through a bolt; when in illumination reaction, the whole device is hung in the illumination machine through the hanging ring 16; a liquid inlet pipe 6-2 is fixedly arranged on the bottom surface of the box body 6-1 on the right side of the first guide pipe 1 through hot melting, and the liquid inlet pipe 6-2 is communicated with the inside of the box body 6-1; a partition plate 6-3 is fixedly arranged on the upper side inside the box body 6-1, the partition plate 6-3 and the box body 6-1 are integrally formed by injection molding, and a shading layer 6-4 is fixedly coated on the outer side wall of the box body 6-1 on the upper side of the partition plate 6-3, so that the illumination on the internal medicament is reduced; a pressing plate 6-5 is movably arranged inside the box body 6-1 on the upper side of the partition plate 6-3, a plurality of pressing blocks 6-6 are fixedly arranged on the bottom surface of the pressing plate 6-5 at equal intervals through hot melting, a plurality of through holes 6-7 are correspondingly formed in the partition plate 6-3, a diaphragm 6-8 is fixedly arranged inside each through hole 6-7, the diaphragm 6-8 is a medical film, the thickness of each pressing block 6-6 is the same as the depth of each through hole 6-7, and a sealing gasket 13 is fixedly arranged on the outer side wall of each pressing block 6-6; when the pressing block 6-6 is embedded in the through hole 6-7, the sealing gasket 13 increases the connection tightness between the pressing block 6-6 and the through hole 6-7; a virus inactivator 6-9 is filled in a cavity inside the box body 6-1 between the pressing plate 6-5 and the partition plate 6-3, and a photosensitizer solution is adopted as the virus inactivator 6-9; a pressure lever 6-10 is vertically and fixedly arranged on the top surface of the pressure plate 6-5 through hot melting, the upper end of the pressure lever 6-10 is movably inserted on the top surface of the box body 6-1 through a sealed linear bearing, a hand-held block 6-11 is fixedly arranged on the upper end head of the pressure lever 6-10 through a bolt, a tension spring 6-12 is sleeved on the pressure lever 6-10 between the top surface of the pressure plate 6-5 and the inner top surface of the box body 6-1, the upper end of the tension spring 6-12 is fixedly connected with the inner top surface of the box body 6-1, and the lower end of the tension spring 6-12 is fixedly connected with the top surface of the pressure; a push plate 6-13 is arranged in the box body 6-1 at the lower side of the partition plate 6-3, elastic gaskets 12 are respectively sleeved on the peripheral walls of the push plate 6-5 and the push plate 6-13 through gluing and fixing, the outer side walls of the elastic gaskets 12 at the periphery of the push plate 6-5 are arranged in a manner of being abutted to the peripheral walls in the box body 6-1, the upper side surface of the elastic gasket 12 at the outer side of the push plate 6-13 is arranged in a manner of being abutted to the bottom surface of the partition plate 6-3, and the front side wall, the rear side wall and the lower side wall of the elastic gasket 12 at the outer side of the push plate 6-13; the connecting part of the pressure plate 6-5 and the push plate 6-13 and the inner side wall of the box body 6-1 is sealed through the elastic sealing property of the elastic gasket 12, the push plate 6-13 is arranged in parallel with the left side wall of the box body 6-1, the right side wall of the push plate 6-13 is vertically and rotatably provided with an external threaded pipe 6-14 through a bearing, the right end of the external threaded pipe 6-14 penetrates through the right side wall of the box body 6-1 through threaded rotation and then extends to the right side of the box body 6-1, and the extending end is fixedly provided with a hand screw 6-15;
a transmission rod 7 is movably arranged inside the external threaded pipe 6-14 in a penetrating mode through a sealed linear bearing, the right end of the transmission rod penetrates through the hand screw 6-15 and then extends to the right side of the hand screw 6-15, a limiting block 8 is fixedly arranged on the extending end through a bolt, a compression spring 9 is sleeved on the transmission rod 7 between the limiting block 8 and the hand screw 6-15, the right end of the compression spring 9 is fixedly connected with the limiting block 8, and the left end of the compression spring 9 is fixedly connected with the right side wall of the hand screw 6-15; the left side wall of each push plate 6-13 is provided with a placing groove 10, the left end of each transmission rod 7 extends into the placing groove 10, two stirring blades 11 are fixedly arranged on the extending ends through hot melting equal fillets, and the two stirring blades 11 are movably embedded into the placing groove 10.
The working principle of the specific embodiment is as follows: blood to be subjected to virus inactivation is conveyed to the interior of the box body 6-1 on the lower side of the partition plate 6-3 through the liquid inlet pipe 6-2, the interior of the box body 6-1 on the lower side of the partition plate 6-3 is in a negative pressure state before liquid inlet, and the push plate 6-13 is positioned on the rightmost side of the box body 6-1; after liquid feeding is finished, the bag inserting needle 2 is connected with the blood storage bag 3, then the pressure plate 6-5 is pressed down through the hand-held block 6-11, the pressure of the virus inactivator 6-9 is pressed by the pressure plate 6-5, so that the diaphragm 6-8 is crushed, the virus inactivator 6-9 enters the blood on the lower side of the partition plate 6-3 through the through hole 6-7 to be contacted with the blood, then the box body 6-1 is placed in an illumination machine to perform illumination reaction, and the virus inactivator 6-9 and light generate photochemical reaction to inactivate viruses in the blood; when the virus inactivator 6-9 is mixed with the blood in the box body 6-1, the left end of the transmission rod 7 drives the stirring blade 11 to leave the placing groove 10 and stretch into the blood by pressing the limiting block 8, the compression spring 9 is in a compressed state at the moment, and then the limiting block 8 is rotated to enable the stirring blade 11 to rotate and stir in the blood, so that the virus inactivator 6-9 is more uniformly mixed with the blood, and meanwhile, the blood is more uniformly contacted with the outside light; when the stirring is finished, the limiting block 8 is loosened, the limiting block 8 is pushed rightwards by the reverse compression force of the compression spring 9, and the stirring blade 11 is restored to be embedded in the placing groove 10; after the reaction is finished, the blood enters the inside of the filtering mechanism 5 through the second conduit 4 and the liquid inlet 5-6, and after the blood sequentially passes through the first filtering layer 5-4 and the second filtering layer 5-5, the blood enters the inside of the first conduit 1 from the liquid outlet 5-7 and finally enters the inside of the blood storage bag 3 for storage; the first filter layer 5-4 and the second filter layer 5-5 filter the photosensitizer and the leucocytes in the virus inactivator 6-9 in the blood; when blood enters the blood storage bag 3, the external threaded pipe 6-14 is rotated by screwing the hand 6-15, the push plate 6-13 slowly moves leftwards, the press plate 6-5 is pressed at the moment, the press block 6-6 is blocked in the through hole 6-7, and the push plate 6-13 continuously extrudes the blood from the second conduit 4 into the filtering mechanism 5.
After adopting above-mentioned structure, this embodiment beneficial effect does:
1. the diaphragm 6-8 arranged in the photochemical inactivation mechanism 6 is damaged by the extrusion of the virus extinguishing agent and then is contacted with blood, so that the operation is more convenient;
2. the push plate 6-13 continuously extrudes the blood from the second conduit 4 into the filtering mechanism 5, so that the filtering efficiency is improved, and meanwhile, the blood in the box body 6-1 is more completely conveyed into the blood storage bag 3;
3. the first filter layer 5-4 and the second filter layer 5-5 in the filter mechanism 5 adopt annular structures, so that the contact area of blood and the first filter layer 5-4 is increased, and the filter efficiency is improved;
4. the stirring blade 11 rotates and stirs in the blood, so that the virus inactivator 6-9 is more uniformly fused with the blood, and simultaneously, the blood is more uniformly contacted with the outside light.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. Disposable blood virus inactivation device which characterized in that: it comprises a blood storage bag (3), a bag inserting needle (2) and a first catheter (1); the lower end of the first conduit (1) is fixedly connected with a bag inserting needle (2), and the end head of the bag inserting needle (2) is inserted into the liquid inlet end of the blood storage bag (3); it also comprises a filtering mechanism (5) and a photochemical inactivation mechanism (6); the upper end of the first conduit (1) is connected with a filtering mechanism (5), the inlet end of the filtering mechanism (5) is fixedly connected with a second conduit (4), and the upper end of the second conduit (4) is fixedly connected with the output end of the photochemical inactivation mechanism (6);
the filtering mechanism (5) comprises an upper sealing cover (5-1), a lower sealing cover (5-2), a shell (5-3), a first filtering layer (5-4) and a second filtering layer (5-5); the shell (5-3) is of a hollow structure with openings at the upper end and the lower end, an upper sealing cover (5-1) is rotatably sleeved on the opening end at the upper side of the shell (5-3) through threads, and a lower sealing cover (5-2) is rotatably sleeved on the opening end at the lower side of the shell (5-3) through threads; a liquid inlet (5-6) is formed in the middle of the upper sealing cover (5-1), the top surface of the upper sealing cover (5-1) is fixedly connected with the lower end of the second guide pipe (4), and the second guide pipe (4) is communicated with the liquid inlet (5-6); a first filter layer (5-4) and a second filter layer (5-5) are sequentially arranged inside the shell (5-3) from inside to outside, the liquid inlet (5-6) is communicated with the middle part of the first filter layer (5-4), the liquid outlet (5-7) is formed inside the lower sealing cover (5-2), the liquid outlet (5-7) is communicated with a gap between the second filter layer (5-5) and the inner side wall of the shell (5-3), the upper end of the first guide pipe (1) is fixedly connected with the bottom surface of the lower sealing cover (5-2), and the first guide pipe (1) is communicated with the inside of the liquid outlet (5-7);
the photochemical inactivation mechanism (6) comprises a box body (6-1), a partition plate (6-3), a pressure plate (6-5), a pressure rod (6-10), a push plate (6-13), an external threaded pipe (6-14) and a tension spring (6-12); the upper end of the first conduit (1) is fixedly arranged at the left side of the bottom surface of the box body (6-1), the first conduit (1) is communicated with the interior of the box body (6-1), and the box body (6-1) is arranged in a transparent manner; a liquid inlet pipe (6-2) is fixedly arranged on the bottom surface of the box body (6-1) on the right side of the first conduit (1), and the liquid inlet pipe (6-2) is communicated with the inside of the box body (6-1); a partition plate (6-3) is fixedly arranged on the upper side inside the box body (6-1), and a shading layer (6-4) is fixedly arranged on the outer side wall of the box body (6-1) on the upper side of the partition plate (6-3); a pressing plate (6-5) is movably arranged inside the box body (6-1) on the upper side of the partition plate (6-3), a plurality of pressing blocks (6-6) are fixedly arranged on the bottom surface of the pressing plate (6-5) at equal intervals, a plurality of through holes (6-7) are correspondingly formed in the partition plate (6-3), diaphragms (6-8) are fixedly arranged inside the through holes (6-7), and the thickness of each pressing block (6-6) is the same as the depth of each through hole (6-7); a virus inactivator (6-9) is filled in a cavity inside the box body (6-1) between the pressing plate (6-5) and the partition plate (6-3); a pressure lever (6-10) is vertically and fixedly arranged on the top surface of the pressure plate (6-5), the upper end of the pressure lever (6-10) is movably inserted on the top surface of the box body (6-1) through a sealed linear bearing, a handheld block (6-11) is fixedly arranged on the upper end of the pressure lever (6-10), a tension spring (6-12) is sleeved on the pressure lever (6-10) between the top surface of the pressure plate (6-5) and the inner top surface of the box body (6-1), the upper end of the tension spring (6-12) is fixedly connected with the inner top surface of the box body (6-1), and the lower end of the tension spring (6-12) is fixedly connected with the top surface of the pressure plate (6-5); a push plate (6-13) is arranged inside the box body (6-1) at the lower side of the partition plate (6-3), the push plate (6-13) is arranged in parallel with the left side wall of the box body (6-1), an external threaded pipe (6-14) is vertically and rotatably arranged on the right side wall of the push plate (6-13) through a bearing, the right end of the external threaded pipe (6-14) penetrates through the right side wall of the box body (6-1) through thread rotation and then extends to the right side of the box body (6-1), and a hand screw (6-15) is fixedly arranged on the extending end.
2. The disposable blood virus inactivation device of claim 1, wherein: a transmission rod (7) is movably arranged in the outer threaded pipe (6-14) in a penetrating mode through a sealed linear bearing, the right end of the transmission rod penetrates through the hand screw (6-15) and then extends to the right side of the hand screw (6-15), a limiting block (8) is fixedly arranged at the extending end of the transmission rod, a compression spring (9) is sleeved on the transmission rod (7) between the limiting block (8) and the hand screw (6-15), the right end of the compression spring (9) is fixedly connected with the limiting block (8), and the left end of the compression spring (9) is fixedly connected with the right side wall of the hand screw (6-15); a placing groove (10) is formed in the left side wall of each push plate (6-13), the left end of each transmission rod (7) extends into the placing groove (10), a plurality of stirring blades (11) are fixedly arranged on the extending ends at equal round angles, and the stirring blades (11) are movably embedded into the placing groove (10); when the virus inactivator (6-9) is mixed with blood in the box body (6-1), the left end of the transmission rod (7) drives the stirring blade (11) to leave the placement groove (10) and stretch into the blood by pressing the limiting block (8), the compression spring (9) is in a compression state at the moment, then the limiting block (8) is rotated, the stirring blade (11) is rotated and stirred in the blood, the virus inactivator (6-9) is more uniformly fused with the blood, and meanwhile, the blood is more uniformly contacted with external light; when the stirring is finished, the limiting block (8) is loosened, the limiting block (8) is pushed rightwards by the reverse compression force of the compression spring (9), and the stirring blade (11) is restored to be embedded in the placing groove (10).
3. The disposable blood virus inactivation device of claim 1, wherein: elastic gaskets (12) are fixedly sleeved on the peripheral walls of the pressing plate (6-5) and the push plate (6-13), the outer side walls of the elastic gaskets (12) on the periphery of the pressing plate (6-5) are arranged in a manner of being abutted to the peripheral walls inside the box body (6-1), the upper side surface of the elastic gasket (12) on the outer side of the push plate (6-13) is arranged in a manner of being abutted to the bottom surface of the partition plate (6-3), and the front side wall, the rear side wall and the lower side wall of the elastic gasket (12) on the outer side of the push plate (6-13) are arranged in a manner of being abutted to the inner side wall of the box body (; the connection part of the pressure plate (6-5) and the push plate (6-13) and the inner side wall of the box body (6-1) is sealed through the elastic sealing performance of the elastic gasket (12).
4. The disposable blood virus inactivation device of claim 1, wherein: a sealing gasket (13) is fixedly arranged on the outer side wall of the pressing block (6-6); when the pressing block (6-6) is embedded in the through hole (6-7), the sealing gasket (13) increases the sealing property of the connection between the pressing block (6-6) and the through hole (6-7).
5. The disposable blood virus inactivation device of claim 1, wherein: a spherical groove (14) is formed in the lower port of the liquid inlet (5-6) in a penetrating manner, steel balls (15) are movably arranged in a cavity in the first filter layer (5-4), and the diameter of each steel ball (15) is matched with that of the spherical groove (14); when the medical staff invert and shake the filter in the shell (5-3), the steel ball (15) is embedded in the spherical groove (14) under the action of gravity, so that the filter liquor in the shell (5-3) is prevented from entering the second conduit (4) again.
6. The disposable blood virus inactivation device of claim 1, wherein: a hanging ring (16) is fixedly arranged on the rear side wall of the box body (6-1); when the illumination reaction is carried out, the whole device is hung in the illumination machine through a hanging ring (16).
7. The disposable blood virus inactivation device of claim 1, wherein: the working principle is as follows: blood to be subjected to virus inactivation is conveyed to the interior of the box body (6-1) on the lower side of the partition plate (6-3) through the liquid inlet pipe (6-2), the interior of the box body (6-1) on the lower side of the partition plate (6-3) is in a negative pressure state before liquid inlet, and the push plate (6-13) is positioned on the rightmost side of the box body (6-1); after liquid feeding is finished, connecting the bag inserting needle (2) with the blood storage bag (3), pressing the pressing plate (6-5) through the handheld block (6-11), pressing the pressure of the virus inactivating agent (6-9) by the pressing plate (6-5) to break the diaphragm (6-8), enabling the virus inactivating agent (6-9) to enter the blood on the lower side of the diaphragm (6-3) through the through hole (6-7) to be contacted with the blood, placing the box body (6-1) in an illumination machine to perform illumination reaction, and enabling the virus inactivating agent (6-9) to perform photochemical reaction with light to inactivate viruses in the blood; after the reaction is finished, the blood enters the inside of the filtering mechanism (5) through the second conduit (4) and the liquid inlet (5-6), and after passing through the first filtering layer (5-4) and the second filtering layer (5-5) in sequence, the blood enters the inside of the first conduit (1) from the liquid outlet (5-7) and finally enters the inside of the blood storage bag (3) for storage; the first filter layer (5-4) and the second filter layer (5-5) filter photosensitizer and leucocytes in the virus inactivator (6-9) in the blood; when blood enters the blood storage bag (3), the external threaded pipe (6-14) is rotated through the hand screw (6-15), the push plate (6-13) moves leftwards slowly, the press plate (6-5) is pressed at the moment, the press block (6-6) is blocked in the through hole (6-7), and the push plate (6-13) continuously extrudes the blood from the second conduit (4) to the inside of the filtering mechanism (5).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011460308.6A CN112386717B (en) | 2020-12-11 | 2020-12-11 | Disposable blood virus inactivation device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011460308.6A CN112386717B (en) | 2020-12-11 | 2020-12-11 | Disposable blood virus inactivation device |
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| CN112386717B CN112386717B (en) | 2022-05-24 |
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| CN112386717B (en) | 2022-05-24 |
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