Digestive tract liquid biopsy sampling device and sampling method for internal medicine
Technical Field
The invention relates to the field of medical biopsy sampling, in particular to a gastrointestinal liquid biopsy sampling device for medical department and a sampling method.
Background
The digestive tract is a long muscular canal extending from the oral cavity to the pharynx, esophagus, stomach, small intestine, large intestine and ending in anal canal, and comprises the parts of the oral cavity, pharynx, esophagus, stomach, small intestine, duodenum, jejunum, ileum, large intestine cecum, appendix, colon, rectum, anal canal and the like. The digestive glands include small digestive glands and large digestive glands. The small digestive gland powder is placed in the wall of each part of digestive tube, and the large digestive gland has three pairs of salivary gland parotid gland, submandibular gland, sublingual gland, liver and pancreas, and all of them can utilize catheter to discharge secretion into digestive tube.
The digestive tract biopsy technique is of great importance for diagnosis of digestive tract diseases. The digestive system problems of the digestive system cause the normal excretion operation of the body of the patient in the digestive system, and in order to specifically analyze the data of the contents of various digestive fluids in the stomach, the mixture of the digestive fluids in the stomach of the patient needs to be extracted by equipment, and then the stomach illness state is judged by detection.
When the existing sampling device is used for sampling, the viscosity of digestive juice is high, so that the sampling position is easy to be blocked, as disclosed in the publication No.: CN111481236a prevents liquid that does not need to be sampled from entering the baffle cylinder through the through hole by misplacement of the sleeve and the baffle cylinder, but cannot prevent the plug from blocking the through hole, and some relatively fine solid particles are extracted along with the digestive juice, and these solid particles contain various substances, which may affect the detection data when detecting the extracted digestive juice.
Disclosure of Invention
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide a digestive tract liquid biopsy sampling device and a sampling method for internal medicine, which can prevent blockage in digestive tract liquid from blocking a sampling position, influence biopsy sampling, directly separate particles in the sampled liquid from the liquid and improve the accuracy of detection data.
2. Technical proposal
In order to solve the problems, the invention adopts the following technical scheme.
The utility model provides a digestive tract liquid biopsy sampling device and sampling method for internal medicine, includes supply pressure section of thick bamboo and liquid collection section of thick bamboo, liquid collection section of thick bamboo right-hand member fixedly connected with sampling tube, the outer wall of supplying pressure section of thick bamboo is close to left position threaded connection has the cover, the inside movable pull rod that has cup jointed of cover, the left end fixedly connected with twist grip of pull rod, the right-hand member of pull rod extends to and supplies pressure section of thick bamboo inside and fixedly connected with pull tab, the pull tab outer wall and the inside contact of supplying pressure section of thick bamboo, the position that supplies pressure section of thick bamboo outer wall to close to the right side is provided with the screw thread, the screw thread groove has been seted up to the position that liquid collection section of thick bamboo inner wall is close to the left side, screw thread and screw thread groove threaded connection, the position of liquid collection section of thick bamboo outside bottom is connected with the liquid storage section of thick bamboo.
The invention is further provided with: the liquid collecting cylinder is characterized in that the front side and the rear side of the inner wall of the liquid collecting cylinder are fixedly connected with first rotating columns, an outer hemispherical shell is rotationally connected between the two first rotating columns, the top of the outer hemispherical shell is fixedly connected with second rotating columns close to the left side and the right side, middle hemispherical shells are rotationally connected between the two second rotating columns, the top of the middle hemispherical shell is fixedly connected with third rotating columns close to the positions of the front side and the rear side, an inner hemispherical shell is rotationally connected between the two third rotating columns, and filtering holes are formed in the outer walls of the outer hemispherical shells, the middle hemispherical shells and the inner hemispherical shells.
The invention is further provided with: the left end fixedly connected with connecting pipe of sampling tube, the one end that the sampling tube was kept away from to the connecting pipe runs through first column spinner, second column spinner and third column spinner and extends to inside the interior hemisphere shell.
The invention is further provided with: the sampling tube is characterized in that a thread bush is fixedly connected to the outer wall of the sampling tube near the left end, the thread bush is communicated with the inside of the sampling tube, a threaded rod is connected with the thread bush in a threaded mode, and a cross rotating handle is fixedly connected to the top of the threaded rod.
The invention is further provided with: the right-hand member fixedly connected with sampling head of sampling tube, even through-hole has been seted up to the sampling head outer wall, sampling tube inner wall just is located the position fixedly connected with inclined tube corresponding with the through-hole, liquid hole has been seted up towards one side in the middle of the sampling head to the inclined tube outer wall.
The invention is further provided with: the inner wall of the right side of the sampling head is fixedly connected with a spring, and the left end of the spring is fixedly connected with a connecting rod.
The invention is further provided with: the bottom fixedly connected with of threaded rod is acted as go-between, the one end that the threaded rod was kept away from to act as go-between is fixed connection with the left end of connecting rod.
The invention is further provided with: the connecting rod outer wall fixedly connected with distributes evenly prevents stifled post, the one end fixedly connected with activity soft post that the connecting rod was kept away from to the anti-blocking post, activity soft post activity is pegged graft inside the inclined tube.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
(1) According to the scheme, the absorbed digestive tract liquid is led into the inner hemispherical shell through the connecting pipe, particulate matters in the digestive tract liquid are filtered out through the inner hemispherical shell, and the filtered liquid is collected through the liquid storage barrel, so that the particulate matters in the sampled liquid can be directly separated from the liquid, and the accuracy of detection data is improved.
(2) According to the scheme, the first rotating column is connected with the outer hemispherical shell in a rotating manner, the second rotating column is connected with the middle hemispherical shell in a rotating manner, the third rotating column is connected with the inner hemispherical shell in a rotating manner, the inner hemispherical shell is always upward in an opening under the action of gravity when the liquid collecting cylinder changes direction, and particles in the inner hemispherical shell cannot fall out and are mixed with liquid again, so that accuracy of detection data is affected.
(3) The rotatory cross revolves when this scheme is used for the threaded rod rotates and pulls the stay wire, and the stay wire pulls the connecting rod and moves towards the outside direction of sample head, and then pulls the flexible post of activity towards the left end motion of inclined tube through preventing stifled post, until the flexible post of activity is pulled to the liquid hole and is close to the one side in the middle of the sample head in, alimentary canal liquid can be absorbed the sample head through-hole and liquid hole, if take place the condition that the through-hole blockked up, revolve the handle through the reverse screwing, under the effect of spring, the connecting rod is pulled and is moved towards the inside direction of sample head, and drive the flexible post motion of activity, the flexible post extrudes the through-hole with the plug, can prevent the plug in the alimentary canal liquid from blockking up the through-hole like this, the stability that the sampling device used is improved.
Drawings
FIG. 1 is a schematic diagram of a front view of the present invention;
FIG. 2 is a schematic cross-sectional view of a pressure feed cylinder according to the present invention;
FIG. 3 is a schematic cross-sectional view of a liquid collection cartridge of the present invention;
FIG. 4 is an enlarged schematic view of the structure of FIG. 3A according to the present invention;
FIG. 5 is a schematic cross-sectional view of a sampling tube according to the present invention;
FIG. 6 is an enlarged schematic view of the structure of FIG. 5B according to the present invention;
FIG. 7 is a schematic cross-sectional view of a sampling head according to the present invention;
Fig. 8 is an enlarged schematic view of the structure of fig. 7C according to the present invention.
The reference numerals in the figures illustrate:
1. A pressure supply cylinder; 2. a liquid collecting cylinder; 3. a sampling tube; 4. a cylinder cover; 5. a pull rod; 6. a rotating handle; 7. a pull tab; 8. a thread; 9. a thread groove; 10. a liquid storage cylinder; 11. a first spin column; 12. an outer hemispherical shell; 13. a second spin column; 14. a middle hemispherical shell; 15. a third spin column; 16. an inner hemispherical shell; 17. filtering holes; 18. a connecting pipe; 19. a sampling head; 20. a thread sleeve; 21. a threaded rod; 22. a cross rotary handle; 23. a pull wire; 24. a through hole; 25. a chute; 26. a liquid hole; 27. a spring; 28. a connecting rod; 29. an anti-blocking column; 30. a movable soft column.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments, and that all other embodiments obtained by persons of ordinary skill in the art without making creative efforts based on the embodiments in the present invention are within the protection scope of the present invention.
Referring to fig. 1-8, an apparatus and a method for sampling a digestive tract liquid biopsy for medical use, comprising a pressure supply cylinder 1 and a liquid collection cylinder 2, wherein the right end of the liquid collection cylinder 2 is fixedly connected with a sampling tube 3, the outer wall of the pressure supply cylinder 1 is tightly screwed with a cylinder cover 4, a pull rod 5 is movably sleeved in the cylinder cover 4, the left end of the pull rod 5 is fixedly connected with a rotating handle 6, the right end of the pull rod 5 extends into the pressure supply cylinder 1 and is fixedly connected with a pull tab 7, the outer wall of the pull tab 7 is contacted with the inner part of the pressure supply cylinder 1, the outer wall of the pressure supply cylinder 1 is tightly provided with a thread 8, the inner wall of the liquid collection cylinder 2 is tightly provided with a thread groove 9, the thread 8 is in threaded connection with the thread groove 9, and the outer bottom side of the liquid collection cylinder 2 is screwed with a liquid storage cylinder 10.
Through adopting above-mentioned technical scheme, pulling rod 5, pull rod 5 drive pull tab 7 to left motion and produce pressure in supplying pressure section of thick bamboo 1, under the effect of pressure, the liquid in the alimentary canal is absorbed in the sampling head 19 through-hole 24 and liquid hole 26, the rethread sampling tube 3 enters into connecting pipe 18, connecting pipe 18 is with the alimentary canal liquid introduction of absorption in interior hemisphere shell 16, the particulate matter in the alimentary canal liquid is filtered through interior hemisphere shell 16, the liquid after the filtration is collected through liquid storage cylinder 10, the particulate matter in the liquid after can be with the sample is direct with the liquid separation, improve the accuracy of detected data.
Referring to fig. 4, the front side and the rear side of the inner wall of the liquid collecting cylinder 2 are fixedly connected with first rotating columns 11, an outer hemispherical shell 12 is rotatably connected between the two first rotating columns 11, the positions, close to the left side and the right side, of the top of the outer hemispherical shell 12 are fixedly connected with second rotating columns 13, a middle hemispherical shell 14 is rotatably connected between the two second rotating columns 13, the positions, close to the front side and the rear side, of the top of the middle hemispherical shell 14 are fixedly connected with third rotating columns 15, an inner hemispherical shell 16 is rotatably connected between the two third rotating columns 15, filtering holes 17 are formed in the outer walls of the outer hemispherical shell 12, the middle hemispherical shell 14 and the inner hemispherical shell 16, the left end of the sampling tube 3 is fixedly connected with a connecting tube 18, and one end, far away from the sampling tube 3, of the connecting tube 18 penetrates through the first rotating columns 11, the second rotating columns 13 and the third rotating columns 15 and extends into the inner hemispherical shell 16.
Through adopting above-mentioned technical scheme, the rotation of first column of revolution 11 and outer hemisphere shell 12 is connected, and the rotation of second column of revolution 13 and middle hemisphere shell 14 is connected, and the rotation of third column of revolution 15 and interior hemisphere shell 16 is connected, can guarantee that liquid collection section of thick bamboo 2 is under the effect of gravity when changing the direction, and the opening is up all the time, and the particulate matter in the interior hemisphere shell 16 can not fall out and mix together with liquid again, influences the accuracy of detected data, can carry out multiple times and filter through the filtration pore 17 that sets up on outer hemisphere shell 12, middle hemisphere shell 14 and the interior hemisphere shell 16, improves the filter effect.
Referring to fig. 6 and 7, a thread sleeve 20 is fixedly connected to the outer wall of the sampling tube 3 near the left end, the thread sleeve 20 is communicated with the inside of the sampling tube 3, a threaded rod 21 is connected to the thread sleeve 20 in a threaded manner, a cross rotary handle 22 is fixedly connected to the top of the threaded rod 21, a spring 27 is fixedly connected to the inner wall of the right side of the sampling head 19, a connecting rod 28 is fixedly connected to the left end of the spring 27, a stay 23 is fixedly connected to the bottom end of the threaded rod 21, one end of the stay 23, far from the threaded rod 21, is fixedly connected with the left end of the connecting rod 28, evenly distributed anti-blocking columns 29 are fixedly connected to the outer wall of the connecting rod 28, one end, far from the connecting rod 28, of the anti-blocking columns 29 is fixedly connected with a movable soft column 30, and the movable soft column 30 is movably inserted into the inclined tube 25.
Through adopting above-mentioned technical scheme, rotatory cross revolve 22 for threaded rod 21 rotates and pulls the stay 23, and the stay 23 pulls the connecting rod 28 to the outside direction motion of sampling head 19, and then through preventing blockking up post 29 pulling activity soft post 30 to the left end motion of chute 25, until activity soft post 30 is pulled to the one side in the middle of liquid hole 26 is close to sampling head 19, alimentary canal liquid can be absorbed into sampling head 19 through-hole 24 and liquid hole 26, if the condition that through-hole 24 blockked up takes place, through the contrary cross revolve 22 of twisting, under the effect of spring 27, connecting rod 28 is pulled to the inside direction motion of sampling head 19, and drive activity soft post 30 motion, activity soft post 30 extrudes the jam through-hole 24, can prevent the jam in the alimentary canal liquid from blockking up through-hole 24.
Referring to fig. 7 and 8, the right end of the sampling tube 3 is fixedly connected with a sampling head 19, a uniform through hole 24 is formed in the outer wall of the sampling head 19, an inclined tube 25 is fixedly connected to the inner wall of the sampling tube 3 and located at a position corresponding to the through hole 24, and a liquid hole 26 is formed in one side of the outer wall of the inclined tube 25 facing the middle of the sampling head 19.
Through adopting above-mentioned technical scheme, the liquid in the alimentary canal is absorbed into sampling head 19 through-hole 24 and liquid hole 26, and rethread sampling tube 3 enters into connecting pipe 18, will pass through the alimentary canal liquid of interior hemispherical shell 16 filtration and collect at last, improves the accuracy of detected data.
When in use: rotating the cross knob 22 to rotate the threaded rod 21 and pull the pull wire 23, pulling the connecting rod 28 by the pull wire 23 to move towards the outer direction of the sampling head 19, further pulling the movable soft column 30 to move towards the left end of the inclined tube 25 through the anti-blocking column 29 until the movable soft column 30 is pulled to one side of the liquid hole 26 near the middle of the sampling head 19, inserting the sampling tube 3 into the alimentary canal of a human body through the oral cavity, then pulling the pull rod 5, driving the pull tab 7 to move leftwards in the pressure supply cylinder 1 and generating pressure by the pull rod 5, absorbing liquid in the alimentary canal into the sampling head 19 through the through hole 24 and the liquid hole 26 under the action of the pressure, then entering the connecting tube 18 through the sampling tube 3, guiding the absorbed alimentary canal liquid into the inner hemispherical shell 16 through the connecting tube 18, filtering out particles in the alimentary canal liquid through the inner hemispherical shell 16, the middle hemispherical shell 14 and the outer hemispherical shell 12, the filtered liquid is collected through the liquid storage cylinder 10, in the process, the first rotary column 11 is rotationally connected with the outer hemispherical shell 12, the second rotary column 13 is rotationally connected with the middle hemispherical shell 14, the third rotary column 15 is rotationally connected with the inner hemispherical shell 16, the opening of the inner hemispherical shell 16 is always upward under the action of gravity when the liquid collection cylinder 2 changes direction, particles in the inner hemispherical shell 16 cannot fall out to be mixed with the liquid again, in the use process, if the situation that the through hole 24 is blocked occurs, the connecting rod 28 is pulled to move towards the direction inside the sampling head 19 by reversely screwing the cross knob 22 under the action of the spring 27, and the movable soft column 30 drives the movable soft column 30 to move, so that the blocking object in the digestive tract liquid can be prevented from extruding out of the through hole 24.
The above description is only of the preferred embodiments of the present invention; the scope of the invention is not limited in this respect. Any person skilled in the art, within the technical scope of the present disclosure, may apply to the present invention, and the technical solution and the improvement thereof are all covered by the protection scope of the present invention.