CN112353403A

CN112353403A - Invasive neural signal acquisition device and method

Info

Publication number: CN112353403A
Application number: CN202011078894.8A
Authority: CN
Inventors: 马晓燕; 张沕琳; 黄恒
Original assignee: Beijing Ningju Technology Co ltd
Current assignee: Beijing Ningju Technology Co ltd
Priority date: 2020-10-10
Filing date: 2020-10-10
Publication date: 2021-02-12

Abstract

The invention discloses an invasive neural signal acquisition device and a method, wherein the device comprises an electrode part, an acquisition and transmission module and a receiving module; the electrode part is implanted into the organism in an invasive way, and the acquisition and transmission module is connected to the electrode part and is used for acquiring the nerve signals of the organism and wirelessly transmitting the nerve signals to the receiving module; the receiving module is used for receiving the neural signal outside the organism and transmitting the neural signal to a computer connected with the receiving module. According to the invasive neural signal acquisition device provided by the invention, the electrode part of the invasive neural signal acquisition device transmits the acquired signal to the receiving module outside the organism in a wireless transmission manner, a wire is not needed, and the invasive neural signal acquisition device is convenient to use.

Description

Invasive neural signal acquisition device and method

Technical Field

The invention relates to the technical field of biological signal acquisition, in particular to an invasive neural signal acquisition device and method.

Background

In the research process of neuroscience, the collection of the neural signals of brain activity, particularly the neural signals of deep brain areas, is helpful for people to understand the working principle of the brain. In the prior art, a nerve signal acquisition device transmits acquired nerve signals out of a body in a wired transmission mode, and the charging is also in a wired charging mode, so that the damage to organisms is large due to the existence of a transmission line; simultaneously, the neural signal collector device has strict requirement to the size, and the integration degree of the neural signal collector device product of prior art is lower, leads to the product size great, is unfavorable for implanting in the organism, and because the volume great can cause harm to the organism, also can not stay for a long time and place in the organism in, is not convenient for use.

Disclosure of Invention

An object of the present invention is to provide a new technical solution of a neural signal acquisition device. The following presents a simplified summary in order to provide a basic understanding of some aspects of the disclosed embodiments. This summary is not an extensive overview and is intended to neither identify key/critical elements nor delineate the scope of such embodiments. Its sole purpose is to present some concepts in a simplified form as a prelude to the more detailed description that is presented later.

According to an aspect of an embodiment of the present invention, there is provided an invasive neural signal acquisition apparatus including

Comprises an electrode part, an acquisition and transmission module and a receiving module;

the electrode part comprises an insulating needle-shaped body, an antenna and a plurality of contacts, and the contacts and the antenna are arranged in the insulating needle-shaped body; the electrode portion is implanted invasively inside a living body;

the acquisition and transmission module is connected to the contact; the acquisition and transmission module is used for acquiring biological nerve signals and wirelessly transmitting the biological nerve signals to the receiving module;

the receiving module is used for receiving the biological nerve signal outside a biological body and transmitting the biological nerve signal to a signal processing terminal connected with the receiving module.

Furthermore, the device also comprises a wireless charging module, and the wireless charging module is used for transmitting electric energy to the acquisition and transmission module in a wireless mode outside the organism.

Furthermore, the wireless charging module comprises a power module, a power amplifier and a transmitting coil which are electrically connected in sequence, and the power module wirelessly transmits electric energy to the acquisition and transmitting module outside the organism through the power amplifier and the transmitting coil.

Further, the wireless charging module is arranged on a binding band with a fastening tape, and the wireless charging module is fixed at a position, which is opposite to the acquisition and transmission module, outside the organism through the binding band.

Furthermore, the acquisition and transmission module comprises an analog front end, an energy management unit and a transmission unit;

the analog front end is connected with each contact, amplifies the neural signal transmitted by each contact and converts the amplified neural signal into a digital signal, and transmits the digital signal to the transmitting unit; (ii) a

The energy management unit is used for receiving and storing the electric energy wirelessly transmitted by the wireless charging module and providing electric energy for the analog front end and the transmitting unit.

Furthermore, the energy management unit is connected with a receiving coil and used for receiving the electric energy wirelessly transmitted by the wireless charging module.

Further, the wireless transmitting unit comprises a transmitting unit connected with an antenna, and the transmitting unit transmits the biological nerve signal to the receiving module through the antenna.

According to another aspect of the embodiments of the present invention, there is provided an invasive neural signal acquisition method implemented by using the invasive neural signal acquisition apparatus, including:

the electrode part is implanted into the organism in an invasive way, and under the condition of being powered by the wireless charging module, the electrode part acquires organism nerve signals and wirelessly transmits the organism nerve signals to the receiving module;

the receiving module receives the biological nerve signal outside the biological body and transmits the biological nerve signal to a computer connected with the receiving module.

Further, the collecting and wirelessly transmitting the biological nerve signal to the receiving module comprises:

the contact arranged in the electrode part is adopted to collect the biological nerve signals and wirelessly transmit the biological nerve signals to the analog front end arranged in the collecting and transmitting module;

the analog front end amplifies the biological nerve signals transmitted by the contact and then converts the signals into digital signals, and transmits the digital signals to a transmitting unit configured in the acquisition and transmission module;

and the transmitting unit transmits the digital signal amplified and converted by the analog front end to the receiving module through an antenna.

The technical scheme provided by the embodiment of the invention has the following beneficial effects:

according to the invasive neural signal acquisition device provided by the invention, the electrode part of the invasive neural signal acquisition device transmits the acquired signal to the receiving module outside the organism in a wireless transmission manner, a wire is not needed, and the invasive neural signal acquisition device is convenient to use.

Further, the wireless charging module of this device charges to gathering emission module with wireless charging mode, has avoided the injury of signal transmission line and charging wire to the organism.

Further, this device integrates the degree height, and is internal at insulating needle with contact and antenna setting to reduced the volume of gathering emission module, made it more be favorable to implanting the organism, convenient to use, greatly reduced to the harmful effects of organism, can keep somewhere in the organism for a long time.

Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by the practice of the embodiments of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of an embodiment of the present disclosure;

FIG. 2 is a block diagram of an embodiment of the present disclosure;

fig. 3 is a schematic structural diagram of an acquisition and transmission module according to another embodiment of the present disclosure;

fig. 4 is an exploded view of the acquisition and transmission module corresponding to fig. 3.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

As shown in fig. 1 and 2, one embodiment of the present disclosure provides an invasive neural signal acquisition device, including a wireless charging module 1, an acquisition transmission module, an electrode part 2, and a receiving module 14; the wireless charging module 1 is used for transmitting electric energy to the electrode part 2 implanted in the organism from the outside of the organism in a wireless transmission mode; the electrode part 2 comprises an insulating needle 5, an antenna 6 and a plurality of contacts 4 (Electrodes); the acquisition and transmission module comprises an acquisition unit and a wireless transmission unit. The contact 4 and the antenna 6 are arranged inside the insulating needle 5.

The wireless charging module 1 comprises a Battery (Battery)7, a Power Amplifier (PA) 8 and a transmitting coil 9 which are electrically connected in sequence, and is used for wirelessly transmitting electric energy to the acquisition transmitting module outside the organism. The transmitting coil 9 is electrically connected to the power amplifier 8. The battery 7 may be a rechargeable battery or other various types of power modules. The wireless charging module 1 is disposed on a strap (not shown) with a hook and loop fastener, and the wireless charging module 1 is fixed to a position facing the electrode portion 2 outside the living body by the strap.

The electrode part 2 is used for being implanted into subcutaneous tissue 3 of a living body in an invasive mode, and the electrode part 2 comprises an acquisition Unit, an energy Management Unit (PMU) 12 and a wireless transmitting Unit;

the acquisition unit includes an Analog Front End (AFE) 10;

the wireless transmitting unit includes a transmitting unit (Transmitter, abbreviated TX)11 electrically connected to the antenna 6;

the contact 4 and the antenna 6 are arranged in the insulating needle-shaped body 5, and the insulating needle-shaped body 5 is made of medical insulating materials harmless to living beings; the insulating needle-like body 5 is inserted into the subcutaneous tissue 3 of the living body in an invasive manner; one end of each contact 4 extends out of the outer surface of the insulating needle-shaped body 5 and is used for collecting neural signals; the other end of each contact 4 is connected to an analog front end 10. The analog front end 10 is connected with each contact 4, amplifies the neural signal transmitted from each contact 4, converts the amplified neural signal into a digital signal, and transmits the digital signal to the transmitting unit 11. Here, the insulating needle 5 may be replaced with an insulator having another shape, which is made of a medical insulating material harmless to living bodies and is inserted into the subcutaneous tissue 3 of a living body in an invasive manner.

The transmitting unit 11 is electrically connected to the analog front end 10, and is configured to transmit the digital signal amplified and converted by the analog front end 10 through the antenna 6. The wireless transmitting unit is used for relaying wireless communication.

The energy management unit 12 is configured to receive and store the electric energy wirelessly transmitted by the wireless charging module, and provide the electric energy for the acquisition unit and the wireless transmission unit. A small receiving coil 13 is connected to an energy Management Unit (PMU) 12, the small receiving coil 13 is coupled to the transmitting coil 9, and the small receiving coil 13 receives the electric energy transmitted by the transmitting coil 9 and stores the electric energy in the energy Management Unit for supplying Power to other modules. The electric energy of the battery 7 is transmitted to the small receiving coil 13 by the transmitting coil 9 after passing through the power amplifier 8, and then is transmitted to the energy management unit 12. The wireless charging module 1 carries out electric energy transmission to the electrode part 2 in a wireless charging mode, can meet the power consumption requirement of long-time use of the acquisition and transmission module, and avoids the damage of a transmission line to an organism.

The receiving module (RX, Receiver)14 is connected to the computer 15, and the receiving module 14 is used for receiving the signal transmitted by the transmitting unit 11 through the antenna 6 and transmitting the signal to the computer 15 for processing.

The electrode part 2 is implanted into subcutaneous tissues of organisms for use and can be used for collecting neural signals in a deep brain region. The wireless charging module 1 is used for wirelessly transmitting electric energy to the electrode part 2 outside the living body. The electrode part 2 is used for collecting nerve signals and wirelessly transmitting the signals.

The electrode part 2 has small volume, is made of a bio-friendly material, can be placed in a living body for a long time, and does not harm the health of the living body.

In another embodiment of the present application, the electrode portion 2 has a structure as shown in fig. 3 and 4, and includes a substrate 16 and a plurality of contacts 4 disposed on a surface of one side of the substrate 16, wherein the contacts 4 are in a shape of a circular disc, and an antenna 6 is also integrated on the substrate 16. The electrode portion 2 is intended to be implanted in the subcutaneous tissue of a living body in an invasive manner for use. The analog front end 10, the transmitting unit 11 are connected to the electrode part 2. An isolation layer 17 is arranged between the antenna 6 and the substrate 16, and another isolation layer 17 is covered on the antenna 6.

An embodiment of the present application provides an invasive neural signal acquisition method implemented by using the invasive neural signal acquisition apparatus, including:

step 1), the electrode part 2 is implanted into the organism in an invasive way, and biological nerve signals are collected and wirelessly transmitted to the receiving module 14;

step 2) the receiving module 14 receives the neural signal from the outside of the living body and transmits the neural signal to the computer 15 connected to the receiving module 14, and the computer 15 may be replaced with another type of signal processing terminal.

Further, an invasive neural signal acquisition method is realized by using the invasive neural signal acquisition device, and the method comprises the following steps:

s1, implanting the electrode part 2 into the organism, and collecting the nerve signals and wirelessly transmitting the nerve signals to the simulation front end 10 by the contact 4;

s2, the analog front end 10 amplifies the nerve signal transmitted from the contact 4, converts the amplified nerve signal into a digital signal, and transmits the digital signal to the transmitting unit 11;

s3, the transmitting unit 11 sends the digital signal amplified and converted by the analog front end 10 to the receiving module 14 through the antenna 6;

s4, the receiving module 14 receives the digital signal sent by the transmitting unit 11 through the antenna 6 and transmits it to the computer 15 for processing.

According to the invasive neural signal acquisition device provided by the invention, the acquisition and emission module transmits the acquired signal to the receiving module outside the organism in a wireless transmission manner, and the wireless charging module charges the acquisition and emission module in a wireless charging manner, so that the damage of a signal transmission line and a charging line to the organism is avoided; in addition, this device integrates the degree height, with contact and antenna setting in insulating needle-like internal to reduced the volume of gathering emission module, made it more be favorable to implanting the organism, convenient to use, greatly reduced to the harmful effects of organism, can keep somewhere in the organism for a long time.

It should be noted that:

the term "module" is not intended to be limited to a particular physical form. Depending on the particular application, a module may be implemented as hardware, firmware, software, and/or combinations thereof. Furthermore, different modules may share common components or even be implemented by the same component. There may or may not be clear boundaries between the various modules.

The algorithms and displays presented herein are not inherently related to any particular computer, virtual machine, or other apparatus. Various general purpose devices may be used with the teachings herein. The required structure for constructing such a device will be apparent from the description above. Moreover, the present invention is not directed to any particular programming language. It is appreciated that a variety of programming languages may be used to implement the teachings of the present invention as described herein, and any descriptions of specific languages are provided above to disclose the best mode of the invention.

In the description provided herein, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in the foregoing description of exemplary embodiments of the invention, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various inventive aspects. However, the disclosed method should not be interpreted as reflecting an intention that: that the invention as claimed requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this invention.

Those skilled in the art will appreciate that the modules in the device in an embodiment may be adaptively changed and disposed in one or more devices different from the embodiment. The modules or units or components of the embodiments may be combined into one module or unit or component, and furthermore they may be divided into a plurality of sub-modules or sub-units or sub-components. All of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or elements of any method or apparatus so disclosed, may be combined in any combination, except combinations where at least some of such features and/or processes or elements are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features included in other embodiments, rather than other features, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the following claims, any of the claimed embodiments may be used in any combination.

The various component embodiments of the invention may be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. Those skilled in the art will appreciate that a microprocessor or Digital Signal Processor (DSP) may be used in practice to implement some or all of the functions of some or all of the components in the creation apparatus of a virtual machine according to embodiments of the present invention. The present invention may also be embodied as apparatus or device programs (e.g., computer programs and computer program products) for performing a portion or all of the methods described herein. Such programs implementing the present invention may be stored on computer-readable media or may be in the form of one or more signals. Such a signal may be downloaded from an internet website or provided on a carrier signal or in any other form.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The usage of the words first, second and third, etcetera do not indicate any ordering. These words may be interpreted as names.

It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

The above-mentioned embodiments only express the embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. An invasive nerve signal acquisition device is characterized by comprising an electrode part, an acquisition and transmission module and a receiving module;

2. The device of claim 1, further comprising a wireless charging module for wirelessly transmitting electric energy to the collecting and transmitting module from outside the living body.

3. The device of claim 2, wherein the wireless charging module comprises a power module, a power amplifier and a transmitting coil which are electrically connected in sequence, and the power module wirelessly transmits electric energy to the collecting and transmitting module from the outside of the organism through the power amplifier and the transmitting coil.

4. The device of claim 2, wherein the wireless charging module is disposed on a strap with a hook-and-loop fastener, and the wireless charging module is fixed outside the living body at a position opposite to the collecting and transmitting module through the strap.

5. The apparatus of claim 2, wherein the acquisition and transmission module comprises an analog front end, an energy management unit, and a transmission unit;

6. The device of claim 5, wherein a receiving coil is connected to the energy management unit for receiving the electric energy wirelessly transmitted by the wireless charging module.

7. The device of claim 5, wherein the wireless transmitting unit comprises a transmitting unit connected with an antenna, and the transmitting unit transmits the biological nerve signal to the receiving module through the antenna.

8. An invasive neural signal acquisition method using the invasive neural signal acquisition apparatus according to any one of claims 1 to 7, comprising:

9. The method of claim 8, wherein the collecting and wirelessly transmitting the biological neural signals to the receiving module comprises: