CN112352882A - Antibacterial compound acidifier, and preparation method thereof - Google Patents
Antibacterial compound acidifier, and preparation method thereof Download PDFInfo
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- CN112352882A CN112352882A CN202011260366.4A CN202011260366A CN112352882A CN 112352882 A CN112352882 A CN 112352882A CN 202011260366 A CN202011260366 A CN 202011260366A CN 112352882 A CN112352882 A CN 112352882A
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- chain fatty
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
Abstract
The invention provides an antibacterial compound acidifier and a preparation method thereof, wherein the acidifier has a growth promoting effect after being added into a piglet feed, is superior to the growth promoting effect of antibiotics, and has the same influence on piglet diarrhea as the antibiotics. The short-chain fatty acid comprises formic acid, ammonium formate and propionic acid, the medium-chain fatty acid is specifically glyceryl laurate, the carrier is specifically silicon dioxide, 1kg of acidifying agent comprises the following components in parts by weight, and the short-chain fatty acid comprises the following components in parts by weight: 200.0-300.0 g of formic acid, 200-300 g of ammonium formate and 60.0-90.0 g of propionic acid; 60.0-90.0 g of lauric glyceride; the content of the carrier silicon dioxide is 220.0-480.0 g; the total weight of the five components is 1 kg.
Description
Technical Field
The invention relates to the technical field of mixed feed additives, in particular to an antibacterial compound acidifier and a preparation method thereof.
Background
The antibiotic added into the feed can effectively promote the growth of animals, improve the production performance of livestock and poultry, reduce the occurrence of diseases and death, and improve the reproductive performance of animals, thereby bringing great commercial value to the animal husbandry. However, the long-term and large-scale use of antibiotics causes drug resistance of animals and residues in the bodies, which directly endangers the health of human beings and animals. The european union has completely banned the use of growth-promoting antibiotics in feed in 2006. In 7/10/2019, the 194 th bulletin of rural agricultural department requires that growth-promoting antibiotics are prohibited from being added into the feed after 7/1/2020, which marks that our country is about to meet the new era of 'feed resistance prohibition', and the research and development of antibiotic substitute products will become the most important work in the animal husbandry industry.
Disclosure of Invention
In order to solve the problems, the invention provides an antibacterial compound acidifier, which has a growth promotion effect after being added into a piglet feed, is superior to the growth promotion effect of antibiotics, and has basically the same influence on piglet diarrhea as the antibiotics.
An antibacterial compound acidifier is characterized in that: the short-chain fatty acid comprises formic acid, ammonium formate and propionic acid, the medium-chain fatty acid is specifically glyceryl laurate, the carrier is specifically silicon dioxide, 1kg of acidifying agent comprises the following components in parts by weight, and the short-chain fatty acid comprises the following components in parts by weight: 200.0-300.0 g of formic acid, 200-300 g of ammonium formate and 60.0-90.0 g of propionic acid;
60.0-90.0 g of lauric glyceride;
the content of the carrier silicon dioxide is 220.0-480.0 g;
the total weight of the five components is 1 kg.
The preparation method of the antibacterial compound acidifier is characterized by comprising the following specific preparation steps:
A. putting medium-chain fatty acid into a melting tank, heating to 75-95 ℃ to completely melt, and placing into a heat-preservation tank for later use;
B. putting formic acid, ammonium formate and propionic acid in a stirring tank according to the proportion and uniformly mixing;
C. and (3) adding silicon dioxide in a corresponding proportion by weight into a mixer, pumping a mixed solution of formic acid, ammonium formate and propionic acid, spraying the medium-chain fatty acid obtained in the step A while the medium-chain fatty acid is hot after spraying, and mixing for 3 minutes by using the mixer after spraying.
It is further characterized in that: the mixer in the step C is a double-shaft paddle mixer;
the variation coefficient of the mixing degree of the finished product is less than 5 percent.
The application of the antibacterial compound acidifier is characterized in that: the addition amount of the additive in the compound feed is 3.0 kg/T-6.0 kg/T.
After the invention is adopted, the antibacterial compound acidifier is applied to the piglet feed, can improve the digestion and absorption of piglets to the feed, reduce diarrhea of piglets and promote the growth of the piglets; in the antibacterial compound acidifier, formic acid, ammonium formate and ammonium propionate can provide energy for organisms, and can also regulate intestinal mucosa immunity, reduce the pH value of gastrointestinal tracts, activate the activity of digestive enzymes and inhibit and kill gram-negative pathogenic bacteria such as escherichia coli and the like by influencing various immune cells; the lauric glyceride has a special chemical structure in the aspect of bacteriostasis, can quickly destroy the structures of cell walls and cell membranes of bacteria and inhibit the generation of bacterial lipase, thereby playing the role of inhibiting the bacteria; the medium-chain and short-chain fatty acids have synergistic effect and more obvious effect, and can continuously act on the whole intestinal tract through amination esterification and a special processing technology, so that the pH of the animal digestive tract is effectively reduced, pathogenic bacteria are inhibited and killed, and the survival of beneficial bacteria is promoted; improving digestive enzyme activity, enhancing intestinal tract immunity barrier, improving intestinal tract health, increasing nutrient digestibility, and enhancing animal immunity.
Detailed Description
An antibacterial compound acidifier: the acidifier comprises short-chain fatty acids, medium-chain fatty acids and a carrier, wherein the short-chain fatty acids comprise formic acid, ammonium formate and propionic acid, the medium-chain fatty acids are lauric glyceride, the carrier is silicon dioxide, 1kg of acidifier comprises the following components in parts by weight, and the short-chain fatty acids correspond to the components and the content of the components: 200.0-300.0 g of formic acid, 200-300 g of ammonium formate and 60.0-90.0 g of propionic acid;
60.0-90.0 g of lauric glyceride;
the content of the carrier silicon dioxide is 220.0-480.0 g;
the total weight of the five components is 1 kg.
Short Chain Fatty Acids (SCFAs) refer to fatty acids with the number of carbon atoms not more than 6, wherein formic acid with the smallest molecular weight has the strongest effect of inhibiting and killing gram-negative bacteria in organic acids, and other small molecular organic acids such as acetic acid, propionic acid and butyric acid are the most important short chain fatty acids in mammalian biology, not only can provide energy for organisms, but also can regulate intestinal mucosa immunity, reduce gastrointestinal tract pH, activate digestive enzyme activity and inhibit and kill gram-negative pathogenic bacteria such as escherichia coli and the like through the influence on various immune cells.
The Medium Chain Fatty Acid (MCFA) refers to fatty acid containing 6-12 carbon atoms, and mainly comprises caproic acid, caprylic acid, capric acid, lauric acid and the like. In the aspect of bacteriostasis, the medium-chain fatty acid has a special chemical structure, so that the medium-chain fatty acid can rapidly destroy the structures of cell walls and cell membranes of bacteria and inhibit the generation of lipase of the bacteria, thereby playing a role in inhibiting the bacteria. In addition, medium chain fatty acid ester, such as alpha-glycerol monolaurate, is combined with virus surface receptor glycoprotein to reduce the capacity of the virus to be combined with cell surface receptors, thereby effectively destroying the integrity of virus envelope and reducing the toxic action of endotoxin and exotoxin produced by bacteria on organisms.
The medium-chain and short-chain fatty acids have synergistic effect, the effect is more obvious, and the medium-chain and short-chain fatty acids can continuously act on the whole intestinal tract through the ammonification esterification and the special processing technology, so that the pH value of the animal digestive tract is effectively reduced, pathogenic bacteria are inhibited and killed, and the survival of beneficial bacteria is promoted; improving the activity of digestive enzyme, enhancing intestinal immunity barrier, improving intestinal health, increasing nutrient digestibility and further enhancing the immunity of animal organisms; quickly providing energy for organisms, reducing negative effects brought by stress and the like. In a word, the medium-short chain fatty acid and the short-chain fatty acid are used as a natural health-care feed additive with high efficiency, no pollution and no residue, can obviously improve the health condition of animals, improve the disease resistance, the individual growth speed and the daily ration utilization efficiency, improve the carcass quality and improve the economic benefit.
In the specific embodiment, the antibacterial compound acidifier 3KG comprises the following components in percentage by weight as shown in table 1:
TABLE 1
| Raw materials | Added in an amount of g |
| Formic acid | 250 |
| Ammonium formate | 250 |
| Propionic acid | 80 |
| Lauric acid glyceride | 80 |
| Silicon dioxide | 340 |
| Total up to | 1000 |
The preparation method comprises the following specific steps:
A. putting the lauric glyceride with the corresponding weight ratio into a melting tank, heating to 75-95 ℃ to completely melt, and placing into a heat-preservation tank for later use;
B. putting formic acid, ammonium formate and propionic acid in a stirring tank according to the proportion and uniformly mixing;
C. and (3) putting microbead-shaped silicon dioxide with the corresponding weight ratio into a double-shaft paddle type mixer, pumping a mixed solution of formic acid, ammonium formate and propionic acid, spraying the medium-chain fatty acid obtained in the step A while the medium-chain fatty acid is hot after spraying, and mixing for 3 minutes by using a mixer after spraying.
The variation coefficient of the mixing degree of the finished product is less than 5 percent.
Instead of the effect of antibiotics on piglet productivity, it was expressed by the following experimental data:
240 weaned piglets which grow up to about 21 days old and have basically consistent weight and good body condition are selected. Randomly dividing into 2 treatment groups, namely an antibiotic group and an antibacterial acidifier group, wherein each group has 8 repetitions, each repetition is 1 column of pigs, and each column has 15 pigs. 3kg/T of antibacterial acidifier group is added, and 800g/T of enramycin with the concentration of 40% and 200g/T of quinocetone with the concentration of 25% are added into the antibiotic group.
The experimental data of the antibiotic group and the antimicrobial acidifying agent group are shown in tables 2 and 3:
TABLE 2
| Treatment of | Antibiotic group | Antibacterial acidifier group |
| Initial weight (kg) | 6.68 | 6.67 |
| Terminal weight (kg) | 11.95 | 12.65 |
| ADG(g/d) | 263.29 | 300.83 |
| ADFI(g/d) | 433.10 | 447.09 |
| F/G | 1.65 | 1.50 |
Table 2 is used to record the influence of the antibacterial compound acidifier on the production performance of piglets
The ADG Chinese meaning is average daily gain, the ADFI Chinese meaning is average daily feed intake, the G/d Chinese meaning is gram/day, and the F/G Chinese meaning is feed-in ratio.
As shown in Table 2, the average daily gain and average daily feed intake of piglets are improved to a certain extent after the antibacterial compound acidifier replaces antibiotics, and the feed conversion ratio is reduced. This shows that the antibacterial compound acidifier can replace antibiotics, and the growth promoting performance is similar to that of the antibiotics.
TABLE 3
| Treatment of | Antibiotic group | Antibacterial acidifier group |
| Diarrhea Rate (%) | 7.28 | 8.52 |
| Index of diarrhea | 0.15 | 0.17 |
| Mortality (%) | 3.83 | 3.35 |
Table 3 is used to record the effect of the antibacterial complex acidifier on diarrhea and mortality of piglets
From the table 3, the diarrhea rate and the diarrhea index of the piglets of each treatment group are very close, which shows that the diarrhea rate of the piglets after replacing antibiotics by the antibacterial compound acidifier is similar to that of the antibiotics.
In conclusion, the antibacterial compound acidifier added into the piglet diet replaces the antibiotic, has the effect of promoting growth, is superior to the effect of promoting growth of the antibiotic, and has basically the same effect on piglet diarrhea as the antibiotic.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (5)
1. An antibacterial compound acidifier is characterized in that: the short-chain fatty acid comprises formic acid, ammonium formate and propionic acid, the medium-chain fatty acid is specifically glyceryl laurate, the carrier is specifically silicon dioxide, 1kg of acidifying agent comprises the following components in parts by weight, and the short-chain fatty acid comprises the following components in parts by weight: 200.0-300.0 g of formic acid, 200-300 g of ammonium formate and 60.0-90.0 g of propionic acid;
60.0-90.0 g of lauric glyceride;
the content of the carrier silicon dioxide is 220.0-480.0 g;
the total weight of the five components is 1 kg.
2. The preparation method of the antibacterial compound acidifier is characterized by comprising the following specific preparation steps:
A. putting medium-chain fatty acid into a melting tank, heating to 75-95 ℃ to completely melt, and placing into a heat-preservation tank for later use;
B. putting formic acid, ammonium formate and propionic acid in a stirring tank according to the proportion and uniformly mixing;
C. and (3) adding silicon dioxide in a corresponding proportion by weight into a mixer, pumping a mixed solution of formic acid, ammonium formate and propionic acid, spraying the medium-chain fatty acid obtained in the step A while the medium-chain fatty acid is hot after spraying, and mixing for 3 minutes by using the mixer after spraying.
3. The process for preparing an antibacterial complex acidifying agent according to claim 2, wherein: the mixer in step C is specifically a twin-shaft paddle mixer.
4. The process for preparing an antibacterial complex acidifying agent according to claim 2, wherein: the variation coefficient of the mixing degree of the finished product is less than 5 percent.
5. The application of the antibacterial compound acidifier is characterized in that: the addition amount of the additive in the compound feed is 3.0 kg/T-6.0 kg/T.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202011260366.4A CN112352882A (en) | 2020-11-12 | 2020-11-12 | Antibacterial compound acidifier, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011260366.4A CN112352882A (en) | 2020-11-12 | 2020-11-12 | Antibacterial compound acidifier, and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107232414A (en) * | 2017-06-16 | 2017-10-10 | 广州市正百饲料科技有限公司 | The compound additive and preparation method of a kind of the feed for piglet |
| CN109393187A (en) * | 2018-12-29 | 2019-03-01 | 福建傲农生物科技集团股份有限公司 | A kind of anti-diarrhea pig feed additive and the preparation method and application thereof |
| CN109511811A (en) * | 2019-01-29 | 2019-03-26 | 潍坊加易加生物科技有限公司 | One kind is for anti-Short-Chain Fatty Acids essential oil formulation and preparation method thereof and its application |
| CN110604226A (en) * | 2018-06-15 | 2019-12-24 | 江苏奥迈生物科技有限公司 | Diarrhea-preventing growth-promoting composite feed additive for weaned piglets and preparation method thereof |
-
2020
- 2020-11-12 CN CN202011260366.4A patent/CN112352882A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107232414A (en) * | 2017-06-16 | 2017-10-10 | 广州市正百饲料科技有限公司 | The compound additive and preparation method of a kind of the feed for piglet |
| CN110604226A (en) * | 2018-06-15 | 2019-12-24 | 江苏奥迈生物科技有限公司 | Diarrhea-preventing growth-promoting composite feed additive for weaned piglets and preparation method thereof |
| CN109393187A (en) * | 2018-12-29 | 2019-03-01 | 福建傲农生物科技集团股份有限公司 | A kind of anti-diarrhea pig feed additive and the preparation method and application thereof |
| CN109511811A (en) * | 2019-01-29 | 2019-03-26 | 潍坊加易加生物科技有限公司 | One kind is for anti-Short-Chain Fatty Acids essential oil formulation and preparation method thereof and its application |
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Address after: 214000 No. 162, donglang Road, zone B, mechanical equipment Industrial Park, Yangjian Town, Xishan District, Wuxi City, Jiangsu Province Applicant after: WUXI HANOVE ANIMAL HEALTH PRODUCTS Co.,Ltd. Address before: 214000 No.8, HUAFA Road, Xishan Economic Development Zone, Wuxi City, Jiangsu Province Applicant before: WUXI HANOVE ANIMAL HEALTH PRODUCTS Co.,Ltd. |
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