CN112352057A - 用于癌症或肿瘤形成评估的组合物和方法 - Google Patents

用于癌症或肿瘤形成评估的组合物和方法 Download PDF

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Publication number
CN112352057A
CN112352057A CN201980039559.6A CN201980039559A CN112352057A CN 112352057 A CN112352057 A CN 112352057A CN 201980039559 A CN201980039559 A CN 201980039559A CN 112352057 A CN112352057 A CN 112352057A
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target
methylation
kit
cancer
sequencing
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Chinese (zh)
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阿瑟瓦·J·高赫
杰弗里·A·戈尔
刘蕊
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Wuyuan Gene Co
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Wuyuan Gene Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980039559.6A 2018-04-12 2019-04-08 用于癌症或肿瘤形成评估的组合物和方法 Pending CN112352057A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862656820P 2018-04-12 2018-04-12
US62/656,820 2018-04-12
PCT/US2019/026395 WO2019199696A1 (en) 2018-04-12 2019-04-08 Compositions and methods for cancer or neoplasia assessment

Publications (1)

Publication Number Publication Date
CN112352057A true CN112352057A (zh) 2021-02-09

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CN201980039559.6A Pending CN112352057A (zh) 2018-04-12 2019-04-08 用于癌症或肿瘤形成评估的组合物和方法

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Country Link
US (1) US20210388445A1 (https=)
EP (1) EP3775290A4 (https=)
JP (1) JP2021520809A (https=)
KR (1) KR20210003795A (https=)
CN (1) CN112352057A (https=)
AU (1) AU2019253569A1 (https=)
CA (1) CA3096668A1 (https=)
SG (1) SG11202009866XA (https=)
TW (1) TW202012638A (https=)
WO (1) WO2019199696A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114959038A (zh) * 2022-06-13 2022-08-30 湖南宏雅基因技术有限公司 一种hoxa9基因甲基化检测试剂及其应用
CN117766028A (zh) * 2022-09-16 2024-03-26 深圳吉因加医学检验实验室 一种基于甲基化差异预测样本来源的方法及装置

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111989407B (zh) 2018-03-13 2024-10-29 格里尔公司 异常的片段检测及分类
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
IL281741B2 (en) 2018-09-27 2026-04-01 Grail Inc Methylation markers and a targeted methylation detection panel
WO2020132572A1 (en) 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
US11795495B1 (en) * 2019-10-02 2023-10-24 FOXO Labs Inc. Machine learned epigenetic status estimator
CA3154354A1 (en) * 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
CN111833965B (zh) * 2019-11-08 2024-06-04 中国科学院北京基因组研究所(国家生物信息中心) 一种尿沉渣基因组dna的分类方法、装置和用途
US20230002832A1 (en) * 2019-11-27 2023-01-05 Keio University Upper urinary tract urothelial carcinoma identification method
IL296453A (en) * 2020-03-20 2022-11-01 Singlera Health Tech Shanghai Ltd Methods and kits for screening colorectal neoplasm
EP4419714A4 (en) * 2021-11-23 2025-02-26 Pleno, Inc. CODED DOSAGES
CN118451202A (zh) * 2021-12-20 2024-08-06 江苏鹍远生物技术有限公司 一种肿瘤检测方法及应用
WO2024117791A1 (ko) 2022-11-29 2024-06-06 주식회사 지씨지놈 식도암 및 위암 진단용 dna 메틸화 마커 및 이의 용도
WO2024137858A2 (en) * 2022-12-22 2024-06-27 Singlera Genomics Inc. Methods and compositions for assessing colorectal cancer
EP4669776A1 (en) * 2023-02-22 2025-12-31 University of Southern California EARLY PAN-CANCER DETECTION AND CFDNA METHYLATION IN THE CONTEXT OF MINIMAL RESIDUAL DISEASE
WO2025203031A2 (en) * 2024-03-26 2025-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of cancer detection by discordant methylation in cfdna

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090108917A1 (en) * 2007-10-31 2009-04-30 Ananthasayanam Chellappa Methods and apparatus to produce fully isolated npn-based bandgap reference
CN103014155A (zh) * 2007-02-21 2013-04-03 奥斯陆大学医院Hf 新型癌症标记物
US20150152505A1 (en) * 2012-05-18 2015-06-04 Clinical Genomics Pty. Ltd. Method of screening for colorectal cancer
CN105339507A (zh) * 2013-02-21 2016-02-17 托马生物科学公司 用于核酸分析的方法、组合物和试剂盒
WO2016138105A2 (en) * 2015-02-24 2016-09-01 Zymo Research Corporation Assays to determine dna methylation and dna methylation markers of cancer
US20170283887A1 (en) * 2014-11-25 2017-10-05 Ait Austrian Institute Of Technology Gmbh Diagnosis of lung cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1942197A1 (de) * 2000-09-01 2008-07-09 Epigenomics AG Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
US20100297067A1 (en) * 2007-05-14 2010-11-25 The Johns Hopkins University Methylation markers for prostate cancer and methods of use
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
US20110223180A1 (en) * 2010-03-11 2011-09-15 Aldape Kenneth D Methods and compositions related to a multi-methylation assay to predict patient outcome
EP2886659A1 (en) * 2013-12-20 2015-06-24 AIT Austrian Institute of Technology GmbH Gene methylation based colorectal cancer diagnosis
US9984201B2 (en) * 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
EP3350344A1 (en) * 2015-09-17 2018-07-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer detection methods
CN116064796A (zh) * 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103014155A (zh) * 2007-02-21 2013-04-03 奥斯陆大学医院Hf 新型癌症标记物
US20090108917A1 (en) * 2007-10-31 2009-04-30 Ananthasayanam Chellappa Methods and apparatus to produce fully isolated npn-based bandgap reference
US20150152505A1 (en) * 2012-05-18 2015-06-04 Clinical Genomics Pty. Ltd. Method of screening for colorectal cancer
CN105339507A (zh) * 2013-02-21 2016-02-17 托马生物科学公司 用于核酸分析的方法、组合物和试剂盒
US20170283887A1 (en) * 2014-11-25 2017-10-05 Ait Austrian Institute Of Technology Gmbh Diagnosis of lung cancer
WO2016138105A2 (en) * 2015-02-24 2016-09-01 Zymo Research Corporation Assays to determine dna methylation and dna methylation markers of cancer
CN107592885A (zh) * 2015-02-24 2018-01-16 兹莫研究公司 测定dna甲基化的分析法和癌症的dna甲基化标记

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SHUICHI ASAKAWA等: "Human BAC library: construction and rapid screening", GENE, vol. 191, no. 1, 20 May 1997 (1997-05-20), pages 69 - 79, XP002095681, DOI: 10.1016/S0378-1119(97)00044-9 *
尹树慧;闫少春;周立社;邵国;: "DNA甲基化和肾癌关系的研究进展", 包头医学院学报, no. 06, 9 December 2014 (2014-12-09) *
杨兰辉;段勇;: "抑癌基因甲基化在肺癌中的研究进展", 国际呼吸杂志, no. 1, 30 December 2005 (2005-12-30) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114959038A (zh) * 2022-06-13 2022-08-30 湖南宏雅基因技术有限公司 一种hoxa9基因甲基化检测试剂及其应用
CN117766028A (zh) * 2022-09-16 2024-03-26 深圳吉因加医学检验实验室 一种基于甲基化差异预测样本来源的方法及装置
CN117766028B (zh) * 2022-09-16 2025-03-11 深圳吉因加医学检验实验室 一种基于甲基化差异预测样本来源的方法及装置

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SG11202009866XA (en) 2020-11-27
US20210388445A1 (en) 2021-12-16
EP3775290A1 (en) 2021-02-17
CA3096668A1 (en) 2019-10-17
TW202012638A (zh) 2020-04-01
EP3775290A4 (en) 2021-12-29
WO2019199696A1 (en) 2019-10-17
JP2021520809A (ja) 2021-08-26
KR20210003795A (ko) 2021-01-12
AU2019253569A1 (en) 2020-10-29

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