CN112346231A

CN112346231A - Reaction observation system

Info

Publication number: CN112346231A
Application number: CN201910721400.4A
Authority: CN
Inventors: 李鼎; 李霞; 刘炳顺; 刘玉超
Original assignee: Shandong Yuanda-Llongwill Educational Science And Technology Ltd
Current assignee: Shandong Yuanda-Llongwill Educational Science And Technology Ltd
Priority date: 2019-08-06
Filing date: 2019-08-06
Publication date: 2021-02-09

Abstract

The application discloses reaction observation system and method thereof, wherein, reaction observation system includes observation device, reaction unit, first sensor and central processing unit, and observation device includes the microscope, the microscope be digital display microscope and with central processing unit signal connection, reaction unit includes the reaction module, central processing unit and first sensor signal connection, first sensor setting is in the reaction module. The reaction observation system enables students to observe slight changes of the reaction in the reaction module in detail through the digital display microscope, and the central processing unit can collect and record reaction parameters in the first sensor and reaction images in the microscope, so that the students can accurately know reaction conditions and states, and the students can understand the experiment and simultaneously can be helped to repeat the experiment according to the changes of the parameters and the reaction.

Description

Reaction observation system

Technical Field

The invention relates to the field of experimental analysis and application, in particular to a reaction observation system convenient for a user to observe a reaction.

Background

Chemistry is a natural discipline based on experiments. The chemical experiment can arouse the learning interest of students, improve the observation ability and thinking ability of the students and is helpful for the formation of chemical concepts.

In the traditional chemical experiment, a mode of observing experimental phenomena by naked eyes is generally adopted. Macroscopic observation only can see macroscopic phenomena such as color change, precipitation, combustion and the like, details in a specific chemical reaction process cannot be seen, students cannot clearly understand chemical changes, reaction parameters in an experiment can not be quantified in many times, the students can only judge the condition of reaction progress according to the change of color and the change of structure in the reaction, the students are not very beneficial to understanding the chemical reaction process, and the students are deepened to understanding of the chemical reaction.

Disclosure of Invention

It is an object of embodiments of the present invention to overcome the disadvantages described in the prior art, and thereby provide a reaction observation system that facilitates observation of reactions.

In a first aspect, an embodiment provides a reaction observation system, which includes an observation device, a reaction device, a first sensor and a central processing unit, wherein the observation device includes a microscope, the microscope is a digital display microscope and is in signal connection with the central processing unit, the reaction device includes a reaction module, the first sensor is disposed in the reaction module, and the central processing unit is in signal connection with the first sensor.

In one embodiment, the reaction module comprises a bottom plate, a reaction chamber and a first channel are arranged on the bottom plate, one end of the first channel is communicated with the reaction chamber, and a first inlet is arranged at the other end of the first channel.

In one embodiment, a first sensor is disposed in the first channel and/or the reaction chamber.

In one embodiment, the substrate comprises one or more of a plastic, PDMS, or quartz material.

In one embodiment, the reaction module further comprises a membrane, wherein the membrane cover is arranged on the bottom sheet, and the reaction chamber and the first channel of the bottom sheet are sealed.

In one embodiment, the membrane comprises one or more of a PDMS material or a composite soft film.

In one embodiment, the reaction module further comprises a first clamp, the first clamp comprises a first main body and a second main body, the first main body is provided with a first groove, the first groove is matched with the reaction module, the reaction module is placed in the first groove, a second channel is arranged in the first main body, the first groove is communicated with the outside through the second channel, the first inlet is communicated with the second channel, and the first main body is detachably connected with the second main body.

In one embodiment, a joint is provided at the second channel.

In one embodiment, the connector is a luer connector or a gas tube connector.

In one embodiment, a seal is provided at the second channel.

In one embodiment, a valve is provided at the first channel and/or the second channel.

In one embodiment, the second body includes a fixed portion and a movable portion, the movable portion is movably mounted on the fixed portion, the fixed portion is movably mounted on the first body, and the first groove is disposed opposite to the movable portion.

In one embodiment, the movable portion is provided with a first light hole, and the first light hole is opposite to the reaction chamber.

In one embodiment, the first body is provided with a second light hole, and the second light hole is opposite to the reaction chamber.

In one embodiment, the movable part is rotatably connected with the fixed part.

In one embodiment, the other end of the movable portion is detachably connected to the first body.

In one embodiment, a fastening piece is arranged on the first main body, the fastening piece is rotatably connected to the first main body, and a fastening groove matched with the fastening piece is arranged at the other end of the movable part.

In one embodiment, a handle is arranged on the buckling piece, and the handle is matched with the buckling groove.

In one embodiment, the handle is rotatably connected with the fastener.

In one embodiment, the observation device further comprises a laboratory table, the laboratory table is detachably mounted on the microscope, and the reaction module is detachably mounted on the laboratory table.

In one embodiment, the experiment table is provided with a first mounting seat and a second mounting seat which are matched with the first clamp, and the first mounting seat is movably arranged on the experiment table.

In one embodiment, a third light hole is formed on the experiment table.

In one embodiment, one or more light sources are provided on the laboratory bench.

In one embodiment, the light source is disposed on the laboratory bench through a gimbaled tube.

In one embodiment, one or more second driving devices are arranged on the experiment table, and the second driving devices are used for driving the experiment table and the microscope to move relatively.

In one embodiment, the reaction observing system further comprises a feeding device, and the feeding device is communicated with the first channel.

In one of the embodiments, the charging device is provided with a second sensor, which is in signal connection with the central processing unit.

In one embodiment, the charging device comprises a first driving device and one or more piston injectors, and the output end of the first driving device is connected with the pistons of the injectors.

In one embodiment, the first driving device is in signal connection with a central processing unit.

In one embodiment, the reaction observation system further includes a liquid storage device, the liquid storage device includes a liquid inlet and a liquid outlet, and the first channel is connected to the liquid inlet and/or the liquid outlet.

In one embodiment, the liquid storage device is further provided with a feed inlet.

In one embodiment, the liquid storage device is provided with a third sensor which is in signal connection with the central processing unit.

In one embodiment, the reaction observation system further comprises a signal transmission device, and the signal transmission device is in signal connection with the central processing unit.

In a second aspect, an embodiment provides a reaction observation method, including: recording images of the reaction and reaction parameters; and sending the image of the reaction and the reaction parameters to the terminal.

In one embodiment, the central processing unit records the image of the reaction through the digital display microscope; the central processing unit records the reaction parameters through the first sensor; the central processing unit transmits the image of the reaction to the terminal.

In one embodiment, the central processing unit receives an indication and controls the condition of the reaction based on the indication.

The reaction observation system in the above scheme enables the student to carefully observe the slight change of the reaction in the reaction module through the digital display microscope, and the central processing unit can collect and record the reaction parameters in the first sensor and the reaction image in the microscope, so that the student can accurately know the reaction conditions and states, and the student can understand the experiment and is also favorable for the student to repeat the experiment according to the change of the parameters and the reaction.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of one embodiment of a reaction observation system.

Fig. 2 is a schematic structural view of the observation apparatus.

FIG. 3 is a schematic structural diagram of the experiment table.

FIG. 4 is a schematic structural view (exploded view) of one embodiment of the reaction module.

FIG. 5 is a schematic structural view (top view) of one embodiment of a reaction module.

FIG. 6 is a schematic diagram of the AA cross-section of one embodiment of the reaction module.

FIG. 7 is a schematic structural view of another embodiment of a reaction module.

FIG. 8 is a schematic view (exploded view) of the structure of the reaction apparatus.

Fig. 9 is a schematic structural view of the first clamp.

Fig. 10 is a schematic structural view of the first clamp.

Fig. 11 is a schematic structural view of the first clamp.

Fig. 12 is a schematic structural view (perspective view) of one embodiment of the charging device.

Fig. 13 is a schematic structural view (side view) of one embodiment of the charging device.

Fig. 14 is a schematic structural view (front view) of one embodiment of the charging device.

FIG. 15 is a schematic view of a liquid storage device.

Fig. 16 is a schematic view of the structure of the pipe (with joint).

Fig. 17 is a signal connection block diagram of the central processing unit.

Fig. 18 is a circuit block diagram of a control execution terminal.

FIG. 19 is a circuit diagram of a master control circuit for controlling the execution end.

FIG. 20 is a circuit diagram of a communication circuit for controlling the execution end.

FIG. 21 is a schematic diagram of a power circuit for controlling the execution terminal.

Fig. 22 is a circuit diagram of a driving circuit for controlling the execution terminal.

Fig. 23 is a circuit block diagram of the measurement terminal.

Fig. 24 shows a master control circuit of the measurement terminal.

Fig. 25 shows a USB interface circuit of the measurement terminal.

FIG. 26 shows a voltage stabilizing circuit at the measurement end.

Fig. 27 is a voltage reference circuit of the measurement terminal.

The labels in the figure are:

1. an observation device; 11. a microscope; 12. a laboratory bench; 121. a first mounting seat; 122. a second mounting seat; 123. a third light-transmitting hole; 124. a light source; 125. a universal tube; 2. a reaction device; 21. a reaction module; 22. a negative film; 221. a reaction chamber; 222. a first channel; 23. a membrane; 24. a first clamp; 25. a first body; 251. a first groove; 252. a joint; 253. a fastener; 255. a second light-transmitting hole; 26. a second body; 261. a fixed part; 262. a movable portion; 263. a first light-transmitting hole; 31. a first sensor; 4. a feeding device; 41. an injector; 42. a first driving device; 43. a lead screw; 5. a liquid storage device; 51. a liquid inlet; 52. a liquid outlet; 53. a feed inlet.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The term "communicate" is also to be understood broadly, i.e., may be direct or indirect via an intermediary. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

As used in this disclosure and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.

The terms "plurality" and "a plurality" in the present disclosure and appended claims refer to two or more than two unless otherwise specified.

Example 1

A reaction observation system is shown in fig. 1 and comprises an observation device 1, a reaction device 2, a first sensor 31 and a central processing unit, wherein the central processing unit is in signal connection with the first sensor 31, the observation device 1 comprises a microscope 11, the microscope 11 is a digital display microscope 11 and is in signal connection with the central processing unit, the reaction device 2 comprises a reaction module 21, and the first sensor 31 is arranged in the reaction module 21.

In the above scheme, the first sensor 31 is used to collect parameters in the reaction module, more specifically parameters of the reaction in the reaction module. Meanwhile, the central processing unit receives and records the parameters. When the user needs, the parameters in the experiment can be called to know the specific reaction condition, so that the user finds the defects in the original experiment, or the parameters of the previous experiment are recorded to repeat the related experiment.

In order to better collect the parameters of the reaction, in some embodiments, the first sensor 31 may be any sensor, such as a PH sensor, a temperature sensor, a flow sensor and/or a pressure sensor, and may also be a conductivity sensor, a turbidity sensor, a colorimetric sensor. In some embodiments, the first sensor 31 is a micro-sensor, a micro-electrode, or the like.

In one embodiment, as shown in fig. 4-7, the reaction module 21 includes a bottom plate 22, a reaction chamber 221 and a first channel 222 are disposed on the bottom plate 22, one end of the first channel 222 is communicated with the reaction chamber 221, and the other end is provided with a first inlet (it should be understood that fluid can enter the first channel 222 and the reaction chamber 221 through the first inlet). In some embodiments, the first channel 222 in the reaction module 21 is a cylindrical groove with a diameter size of 0.1-5 mm, preferably 0.4-1 mm, and the reaction chamber 221 has a size: the height is 0.1-5 mm, preferably 1-5 mm, and the diameter is 0.1-10 mm, preferably 1-5 mm. The first channel 222 and the reaction chamber 221 form a closed micro structure, which enables the flow of the reaction substance in the reaction module 21 to be more controllable, so that the focus can be adjusted more easily by observing the microscope 11, and the field of view is clearer, thereby facilitating the observation of the reaction change. And the relatively closed design also reduces the intensity of the reaction, enhances the safety of the experiment, simultaneously can prevent the reagent from splashing to pollute the objective lens of the microscope 11, and is convenient for collecting and processing the reaction product.

It should be understood that the above-mentioned scheme only illustrates two ends of the first channel 222, and the first channel 222 may be provided with more ports, and other ports may be communicated with other first channels 222.

In one embodiment, as shown in fig. 6, a first sensor 31 is disposed in the first channel and/or the reaction chamber 221.

In one embodiment, the bottom sheet 22 may be made of any material, such as quartz, metal, graphite, etc., and preferably, the bottom sheet 22 comprises one or more of plastic, PDMS, or quartz.

In one embodiment, the reaction module 21 further comprises a membrane 23, the membrane 23 is covered on the bottom sheet 22, and the reaction chamber 221 and the first channel 222 of the bottom sheet 22 are sealed. It should be understood that the sealing referred to herein does not include sealing the connection between the reaction chamber 221 and the first channel 222, the connection between the first channel 222 and the other first channels 222, and the inlet and outlet of the first channels 222. As in some embodiments, the reaction chamber 221 and the first channel 222 are a groove structure on the bottom plate 22, the groove opening is upward, and the membrane 23 is covered on the bottom plate 22, so as to seal the upward openings of the reaction chamber 221 and the first channel 222. In one embodiment, the membrane 23 comprises one or more of a PDMS material or a composite soft film. It should be understood that although the structure in this embodiment is that the membrane 23 and the bottom sheet 22 cooperate to form the sealed first channel 222 and the reaction chamber 221 (the first inlet of the first channel 222 is not sealed), it is also possible that the bottom sheet 22 itself forms the sealed first channel 222 and the reaction chamber 221 (the inlet and the outlet 52 of the first channel 222 are not sealed).

In one embodiment, the reaction module 21 further includes a first clamp 24, as shown in fig. 8 to 11, the first clamp 24 includes a first body 25 and a second body 26, the first body 25 is provided with a first groove 251, the first groove 251 is matched with the reaction module 21, the reaction module is placed in the first groove, the first body 25 is provided with a second passage, the first groove 251 is communicated with the outside through the second passage, the first inlet is communicated with the second passage, and the first body 25 is detachably connected with the second body 26. It should be understood that the reaction module 21 is placed in the first groove 251 at the time of observation.

In one embodiment, a joint 252 is provided at the second passage. In one embodiment, the connector 252 is a luer connector or a gas line connector. The joint 252 is arranged to enable a user to connect an instrument (such as the liquid storage device 5, the feeding device 4, etc.) with the joint 252 through a pipeline, so as to communicate the first channel 222 with an external instrument. And the installation of the pipeline and the joint 252 can be completed by simply plugging, thereby further facilitating the use of users. In one embodiment, as shown in FIG. 16, a fitting 252 is provided on the pipe, and the fitting 252 on the pipe mates with the fitting 252 of the second passageway.

In one embodiment, a seal is provided at the second channel. In some embodiments, the sealing element is a sealing gasket, a rubber ring, a rubber gasket, a non-asbestos gasket, or the like. It should be understood that although the first inlet and the second channel communicate with each other when the reaction module 21 is placed on the first groove 251, there may be a gap therebetween, causing a liquid (gas) leakage, and thus, a sealing member is provided at the second channel to reduce the possibility of liquid (gas) leakage.

In one embodiment, a valve is provided at the first channel 222 and/or the second channel.

In one embodiment, as shown in fig. 8, the second body 26 includes a fixed portion 261 and a movable portion 262, the movable portion 262 is movably mounted on the fixed portion 261, the fixed portion 261 is movably mounted on the first body 25, and the first groove 251 is disposed opposite to the movable portion 262 (since the movable portion is in a movably mounted state, it should be understood that the above-mentioned relative arrangement is referred to as a relative arrangement in a certain state, and it is not referred to that the movable portion is referred to as a relative arrangement in all states and is not referred to as a relative arrangement in all states, and as in this embodiment, when the state referred to in my side is that the locking groove is matched with the locking member 253, the first groove 251 is referred to as a relative arrangement with the movable portion 262). In one embodiment, the movable portion 262 is rotatably connected to the fixed portion 261. It should be understood that the movable portion 262 can be slidably coupled, bolted, to the fixed portion 261, in addition to being rotatably coupled to the fixed portion 261. Furthermore, in one embodiment, the fixing portion 261 is bolted to the first body 25, and it should be understood that the fixing portion 261 may be movably mounted on the first body 25 by bolting, may be slidably mounted on the first body 25, and the like.

In one embodiment, the other end of the movable portion 262 is detachably connected to the first body 25. In one embodiment, a fastening member 253 is disposed on the first main body 25, the fastening member 253 is rotatably connected to the first main body 25, a fastening groove matched with the fastening member 253 is disposed on the other end of the movable portion 262, and the other end of the movable portion 262 is fixed to the first main body 25 through the matching of the fastening groove and the fastening member 253. In one embodiment, the fastening member 253 is provided with a handle, and the handle is matched with the fastening groove. In one embodiment, the handle is rotatably connected to the latch 253.

It should be understood that although the movable portion 262 and the first body 25 are assembled and disassembled by the locking member 253 in the above embodiment, the other end of the movable portion 262 can be detachably mounted on the first body 25 by magnetic connection, bolt connection, glue connection, etc.

In some embodiments, if the reaction module 21 is to be placed in the first fixture 24 for fixing, the reaction module 21 is first placed in the first groove 251, and then the screw is adjusted to control the relative position of the fixing portion 261 and the first body 25, so as to adjust the acting force of the movable portion 262 on the reaction module 21, and ensure that the acting force is relatively proper, so that the reaction module 21 is tightly attached to the first body 25, and the first inlet and the second channel are sealed from liquid (gas) leakage. The other side of the movable part 262 is fastened to the first body 25 by a fastening structure.

In the above scheme, firstly, the fixing part 261 is movably connected with the first body 25 to fix the relative position between the fixing part 261 and the first body 25, so that a user can adjust the relative position according to the thickness of the reaction module 21, and the scheme can be adapted to different reaction modules 21. In addition, the movable part 262 is clamped with the first main body 25 through a clamping structure arranged on the other side of the movable part 262, so that two sides of the movable part 262 are fixed with two sides of the first main body 25, and the relative positions of the movable part 262, the reaction module 21 (clamped between the movable part 262 and the first main body 25) and the first main body 25 are stable and are not easy to change. Moreover, since the movable portion 262 is movably mounted on the fixed portion 261, the user can complete the disassembly and assembly of the reaction module 21 only by moving the movable portion 262 and opening the snap structure without adjusting the screw between the fixed portion 261 and the first body 25 under the condition that the user does not replace the reaction module 21, thereby greatly improving the convenience of the apparatus.

In one embodiment, the fixing portion 261 is provided with a limiting member for limiting the movable range of the movable portion 262. In addition to the movable portion 262 being limited by the limiting member, the limiting function can be achieved by the special design of the fixed portion 261 and the movable portion 262, for example, in one embodiment, when the movable portion 262 reaches the limiting position, a part of the side surface of the fixed portion 261 abuts against the side surface of the movable member.

In order to make the user observe the reaction in the reaction module 21 in a brighter environment, so that the observation is clearer and clearer, in one embodiment, the movable portion 262 is provided with a first light-transmitting hole 263, and the first light-transmitting hole 263 is disposed opposite to the reaction chamber 221. In one embodiment, the first body 25 is provided with a second light hole 255, and the second light hole 255 is disposed opposite to the reaction chamber 221 (since the movable portion is in the movable configuration, it should be understood that the above-mentioned relative configuration refers to a relative configuration in a certain state, and does not mean that the second light hole 255 is disposed opposite to the first groove 251 in all states).

In one embodiment, as shown in fig. 2, the observation device 1 further comprises a laboratory table 12, the laboratory table 12 is detachably mounted on the microscope 11, and the reaction module 21 is detachably mounted on the laboratory table 12. In some embodiments, the experiment table 12 is provided with a first fixing structure, and the experiment table 12 is fixed on the microscope 11 through the first fixing structure, which may be a snap structure, a bolt structure, or a magnetic connection structure; in some embodiments, the first fixed structure is a jackscrew that is movably attached to the laboratory bench 12 and the microscope 11. In some embodiments, one end of the screw thread passes through the experiment table 12 and onto the microscope 11, and the screw thread is respectively connected with the experiment table and the microscope 11.

In one embodiment, as shown in fig. 3, the experiment table 12 is provided with a first mounting seat 121 and a second mounting seat 122 matched with the first clamp 24, and the first mounting seat 121 is movably arranged on the experiment table 12.

In one embodiment, the experiment table 12 is provided with a third light hole 123.

It should be understood that the first light hole 263, the second light hole 255, and the third light hole 123 may have any shape of through hole structure, such as a circle, a square, a polygon, and the like. The first light hole 263, the second light hole 255 and the third light hole 123 are mainly used to reduce the shielding of the structure from light, so that the light can irradiate the reaction chamber 221 and/or the first channel 222.

In one embodiment, one or more light sources 124 are provided on the laboratory bench 12. In one embodiment, the light source 124 is disposed on the laboratory bench 12 via a gimbaled tube 125. In the above solution, the light source 124 is installed on the experiment table 12 through the universal tube 125, so that the user can adjust the angle, height and brightness of the light source 124 at will, and the problem that the microscope 11 has no light source 124 or cannot adjust the height and angle at will is solved. In some embodiments, the bottom of the gimbal tube 125 is threaded and is attached to the laboratory bench 12 via a threaded connection.

In one embodiment, one or more second driving devices are disposed on the experiment table 12, and the second driving devices are used for driving the experiment table 12 and the microscope 11 to move relatively. The above solution is to arrange a plurality of driving devices on the implementation platform, so that the user can adjust the positions of the microscope 11 and the experiment platform 12 according to the actual situation, so that the microscope 11 can observe the conditions of different positions in the reaction module 21, in one embodiment, the second driving device is in signal connection with the central processing unit; by signal-connecting the second drive means to the central processing unit, the user can manipulate the second drive means via the central processing unit, thereby remotely adjusting the relative movement of the laboratory table 12 and the microscope 11.

In one embodiment, the reaction observing system further comprises a feeding device 4, and the feeding device 4 is communicated with the first channel 222. The feeding device 4 may be any device for supplying material, such as a liquid supply device or a gas supply device, for supplying gas or liquid into the first channel and the second channel.

In one of the embodiments, the charging device 4 is provided with a second sensor, which is in signal connection with the central processing unit. In some embodiments, the charging device is connected to the first channel by a second channel, and the second channel is provided with a fitting 252, and the charging device 4 is connected to the fitting 252 by a pipe. It is to be understood that the second sensor may be any sensor, such as a PH sensor, a temperature sensor, a pressure sensor and/or a flow sensor, but also a conductivity sensor, a turbidity sensor, a colorimetric sensor.

In one embodiment, as shown in fig. 12-14, the charging device 4 may comprise a first driving device 42 and one or more piston injectors 41, wherein the output end of the first driving device 42 is connected with the pistons of the injectors 41. In one embodiment, the first driving device 42 is in signal connection with a central processing unit. In one embodiment, the liquid loading module comprises a first driving device 42 (motor), a first injector 41, a second injector 41, an injector 41 pressure plate, an injector fixing table, a slider assembly, a lead screw 43 fixing column, a housing, a controller interface, an injector 41 piston baffle, a bolt and a lead screw 43 fixing bearing. One end of the lead screw 43 is connected with the output end of the first driving device 42 through a lead screw 43 fixing column, the other end of the lead screw 43 is connected with the pistons of the first injector 41 and the second injector 41 through a slider assembly, and the first injector 41 and the second injector 41 are installed on the shell through an injector 41 fixing table. A pressing plate is arranged on the injector 41 fixing table and used for further fixing the injector 41. It should be understood that the first driving device 42 may be an electric motor, a hydraulic pump, a pneumatic pump, a motor, etc.

In one embodiment, the reaction observing system further includes a liquid storage device 5, as shown in fig. 15, the liquid storage device 5 includes a liquid inlet 51 and a liquid outlet 52, and the first channel is connected to the liquid inlet 51 and/or the liquid outlet 52. It should be understood that the bottom sheet is provided with a plurality of first channels, a part of the first channels can be used for liquid inlet, and a part of the first channels can be used for liquid outlet (the first channels can be used for liquid inlet or all for liquid outlet), so that the first channels can be connected with the liquid inlet 51 and/or the liquid outlet 52 according to the situation. It will be appreciated that in some embodiments, the first passage is connected to inlet port 51 and/or outlet port 52 by a second passage. Or in some embodiments, the first channel is directly connected to inlet port 51 and/or outlet port 52.

In one embodiment, the liquid storage device 5 is further provided with a feed opening 53. The user can supply liquid to the liquid storage device 5 through the feed opening 53, and the liquid of the liquid storage device 5 is prevented from being consumed completely due to long-time reaction. In some embodiments, the feed port 53 is disposed above the reservoir 5 to prevent the reservoir 5 from tilting to cause the liquid in the reservoir 5 to flow out.

In one embodiment, the liquid storage device 5 is provided with a third sensor, and the third sensor is in signal connection with the central processing unit. It is to be understood that the third sensor may be any sensor, such as a PH sensor, a temperature sensor, a pressure sensor and/or a flow sensor, and may also be a conductivity sensor, a turbidity sensor, a colorimetric sensor. In one embodiment, the liquid storage device 5 is further provided with a first support for placing a third sensor.

In one embodiment, the reaction observation system further comprises a signal transmission device, and the signal transmission device is in signal connection with the central processing unit. It is to be understood that the signal transmission means may be wired signal transmission means and/or wireless signal transmission means.

It should be understood that the first channel 222 and the second channel may be straight, polygonal, curved, bent, or otherwise shaped.

And the reaction module 21 may be circular, rectangular or polygonal. And the bottom sheet 22 (and/or the combination of the bottom sheet 22 and the membrane 23) may be a microfluidic chip, or similar structure.

In one embodiment, the central processing unit may be a CPU, a single chip, a PLC, a control circuit, or other devices with data processing and recording functions.

In one embodiment, as shown in fig. 17, the central processing unit may be in signal connection with the first sensor 31, the second sensor, the third sensor, the first driving device 42, the second driving device, the microscope 11 and the signal transmission device.

In one embodiment, the central processing unit includes a control circuit for controlling the execution terminal and a control circuit for controlling the measurement terminal.

In one embodiment, as shown in fig. 18, a control circuit for controlling the execution end is composed of a power circuit, a main control circuit, a driving circuit, and a communication circuit. The power circuit is respectively connected with the main control circuit, the driving circuit and the communication circuit. The main control circuit is respectively connected with the driving circuit and the communication circuit.

Fig. 19 shows a main control circuit for controlling the execution end by the control device. Mainly comprises a singlechip U5 and a peripheral circuit. The J5 is a program downloading interface of the singlechip U5, the 3 rd pin of the J5 is connected to the 72 th pin (SWDIO) of the singlechip U5, and the 5 th pin of the J2 is connected to the 76 th pin (SWCLK) of the singlechip U5. The crystal oscillator Y1(8MHz) provides an oscillation signal for the single chip microcomputer U5, and is connected to the 13 th pin (OSC _ IN) and the 14 th pin (OSC _ OUT) of the single chip microcomputer U5, and one end of each of the capacitors C10 and C11 is connected to both ends of the crystal oscillator Y1, and the other end is grounded.

Fig. 20 shows a communication circuit of the chemical experiment measurement control device controlling the execution end. The USB socket mainly comprises a USB seat 1, a MOS tube Q3 and a patch fuse PTC 1. And the 2 pin and the 11 pin of the USB seat are connected to a 5V power supply through patch fuses and used for controlling the power supply of the execution end. The 6 and 8 pins of the USB seat are connected with the 70 pins of the U5 singlechip through an R38 current-limiting resistor after being short-circuited; the 7 and 9 pins of the USB seat are connected with the 71 pin of the U5 singlechip through an R39 current-limiting resistor after being short-circuited; the pull-up composed of the MOS transistor Q3, the resistor R40 and the resistor R41 is connected to the short circuit position of the

pins

6 and 8 of the USB seat and used for setting the speed mode of USB communication.

Fig. 21 shows a power supply circuit for controlling the execution terminal. The BUCK circuit mainly comprises a BUCK BUCK chip U4 and an LDO power supply chip U16. The power adapter is connected to the circuit through a J3 power socket and is connected to D24 through an F1 fuse, and the D24 is used for protecting a rear-stage circuit from being damaged when overvoltage is input. The 12V power supply is converted into a 5V power supply through the U4 and flywheel diodes D3 and L1 energy storage inductors. The 5V power supply is converted into a 3.3V power supply through U16 and ceramic filter capacitors of C4 and C9.

Fig. 22 shows a drive circuit for controlling the execution terminal. The motor driving chip mainly comprises a U1 motor driving chip.

The

pins

2, 16 and 19 of the U1 are respectively connected with the

pins

34, 18 and 33 of the main control circuit U5 singlechip, and are used for controlling the rotating speed and the direction of the motor. The pin 15 of U1 is connected with 3.3V voltage, and the

pins

22 and 28 are connected with 12V voltage. The

pins

1, 21, 24 and 26 of the U1 are connected with a motor. And the 0.1 ohm resistors R15 and R16 are connected with the

pins

23 and 27 of the U1 and are used for preventing the motor from being burnt out due to overcurrent. The 3.3V power supply is connected to the 17 pin of U1 through R9 and R10 partial voltage and is used for determining the maximum current flowing by the motor.

Fig. 23 is a circuit block diagram of the measurement terminal. The circuit at the measuring end of the chemical experiment measurement control device consists of a main control circuit, a voltage stabilizing circuit, a voltage reference circuit, a USB interface circuit and a sensitive element signal conditioning circuit. The rest of the circuit is a universal part of the circuit of the measuring end.

The main control circuit of the test end is connected with the voltage stabilizing circuit, the voltage reference circuit, the USB interface circuit and the sensitive element signal conditioning circuit. The voltage stabilizing circuit is connected with the main control circuit and the voltage reference circuit. The USB interface circuit is connected with the voltage stabilizing circuit and the main control circuit.

Fig. 24 is a main control circuit of the measuring terminal, which mainly comprises a single chip microcomputer U3 and a peripheral circuit. J1 is the program download interface of the single chip U3, and the crystal oscillator Y1 provides oscillation signals for the single chip U3. C10, C15 and C3-C6 are decoupling capacitors of the single chip microcomputer, one end of each decoupling capacitor is grounded, and the other end of each decoupling capacitor is connected to

pins

1, 24, 36, 48 and 9 of the single chip microcomputer U3.

Fig. 25 shows a USB interface circuit of the measurement terminal, which is mainly composed of a USB socket USB1, a fet Q1, and a peripheral resistor. The 2 nd and 11 th pin circuits of the USB interface USB1 provide power for the measuring end, and the 5 th, 7 th, 6 th and 8 th pins of the USB1 are respectively connected with the 32 th and 33 th pin USB interfaces of the singlechip U3 through resistors R2 and R3. The 38 th pin of the singlechip U3 controls the resistor R1 connected with the 5 th pin and the 7 th pin of the USB1 to be connected to 3.3V voltage by controlling the on-off of the field effect transistor Q1.

Fig. 26 is a voltage stabilizing circuit at the measurement end, and the voltage stabilizing circuit is composed of a voltage stabilizing chip U7(XC6219), a capacitor C1, and a capacitor C2. The 1 st pin of the voltage stabilizing chip U7 is connected with the 5V voltage output by the USB interface circuit or the sensor interface circuit, and the 2 nd pin is grounded. The 5 th pin of the voltage stabilizing chip U7 can output 3.3V voltage to provide power for the main control circuit and the voltage reference circuit. One end of the capacitor C2 is grounded, and the other end is connected to the 1 st pin of the voltage stabilizing chip U7. Pin 2 of the voltage stabilization chip U7 is connected with pin 1.

Fig. 27 shows a voltage reference circuit at a measurement terminal, which includes a voltage reference chip U5(REF3012aid bzr), a capacitor C7, and a capacitor C8. The 1 st pin of the voltage reference chip U5 is connected with a 3.3V power supply, and the 2 nd pin is connected with the ground. The 2 nd pin of the voltage reference chip U5 provides 1.25V voltage reference for the singlechip U3 and the sensitive element signal conditioning circuit of the main control circuit. One end of the capacitor C8 is grounded, and the other end is connected to the 1 st pin of the voltage reference chip U5.

Example 2

A method of reaction observation comprising: recording images of the reaction and reaction parameters; and sending the image of the reaction and the reaction parameters to the terminal.

In one embodiment, the central processing unit records images of the reaction through the digital display microscope 11; the central processing unit records the reaction parameters through the first sensor 31; the central processing unit transmits the image of the reaction to the terminal.

In one embodiment, the central processing unit receives an indication from the terminal and controls the condition of the reaction based on the indication. The reaction conditions include the amount of reactants added, the temperature of the reaction, and the reaction pressure, pH, and the like.

It should be understood that the terminal can be a computer, a mobile phone, a tablet and the like. It should also be understood that the above method can be implemented using the structure in embodiment 1.

By the method, the user can include, but is not limited to, the following three using methods according to actual situations:

(1) observation and recording mode: the chemical experiment process is observed in real time through the microscope 11, and the experiment phenomenon is uploaded to a computer or mobile equipment (a mobile phone, a tablet and the like) through the digital microscope 11 in a USB, CD-ROM or wireless mode.

(2) Observation recording + measurement mode: the chemical experiment process is observed in real time through the microscope 11, the data of the experiment process is measured and recorded through the sensor and the central processing unit, and the experiment phenomenon and the measured data are uploaded to a computer or mobile equipment (a mobile phone, a tablet and the like) through the digital microscope 11 and the sensor module in a USB, optical drive or wireless mode respectively.

(3) Observation recording + measurement + control mode: the experimental process is observed in real time through the microscope 11, the experimental process data is measured and recorded through the sensor and the central processing unit, the experimental conditions and the experimental process are controlled on the control device (such as the feeding device 4 and the valve) through the computer or the mobile device (such as a mobile phone, a tablet and the like), and the experimental phenomenon and the measured data are uploaded to the computer or the mobile device (such as a mobile phone, a tablet and the like) through the digital microscope 11 and the measuring end in a USB (universal serial bus), optical drive or wireless mode.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The utility model provides a reaction observation system, its characterized in that includes observation device, reaction unit, first sensor and central processing unit, and wherein, observation device includes the microscope, the microscope is digital display microscope and with central processing unit signal connection, reaction unit includes reaction module, first sensor setting is in reaction module, central processing unit and first sensor signal connection.

2. The reaction observation system of claim 1, wherein the reaction module comprises a bottom plate, the bottom plate is provided with a reaction chamber and a first channel, one end of the first channel is communicated with the reaction chamber, and the other end of the first channel is provided with a first inlet;

preferably, a first sensor is arranged in the first channel and/or the reaction chamber;

preferably, the substrate comprises one or more of a plastic, PDMS or quartz material;

preferably, the reaction module further comprises a membrane, the membrane is covered on the bottom sheet, and the reaction chamber and the first channel of the bottom sheet are sealed; more preferably, the membrane comprises one or more of a PDMS material or a composite soft film.

3. The reaction observation system of claim 2, wherein the reaction module further comprises a first clamp, the first clamp comprises a first body and a second body, the first body is provided with a first groove, the first groove is matched with the reaction module, the reaction module is placed in the first groove, the first body is provided with a second channel, the first groove is communicated with the outside through the second channel, the first inlet is communicated with the second channel, and the first body is detachably connected with the second body;

preferably, a joint is arranged at the second channel, and preferably, the joint is a luer joint or a gas pipe joint;

preferably, a seal is provided at the second passage;

preferably, a valve is provided at the first channel and/or the second channel.

4. A reaction observing system according to claim 3, wherein the second body includes a fixed portion and a movable portion, the movable portion is movably mounted on the fixed portion, the fixed portion is movably mounted on the first body, and the first recess is disposed opposite to the movable portion;

preferably, the movable part is provided with a first light hole, and the first light hole is opposite to the reaction chamber;

preferably, a second light hole is arranged on the first main body, and the second light hole is arranged opposite to the reaction chamber;

preferably, the movable part is rotatably connected with the fixed part;

preferably, the other end of the movable part is detachably connected with the first main body; more preferably, the first main body is provided with a buckle part, the buckle part is rotatably connected to the first main body, and the other end of the movable part is provided with a buckle groove matched with the buckle part; more preferably, the buckle piece is provided with a handle, and the handle is matched with the buckle groove; more preferably, the handle is rotatably connected with the fastener.

5. A reaction observing system according to claim 3, wherein the observing apparatus further comprises a laboratory table, the laboratory table being detachably mounted on the microscope, the reaction module being detachably mounted on the laboratory table;

preferably, a first mounting seat and a second mounting seat which are matched with the first clamp are arranged on the experiment table, and the first mounting seat is movably arranged on the experiment table;

preferably, a third light hole is arranged on the experiment table;

preferably, one or more light sources are arranged on the experiment table, and more preferably, the light sources are arranged on the experiment table through a universal tube;

preferably, one or more second driving devices are arranged on the experiment table and used for driving the experiment table and the microscope to move relatively;

preferably, the second driving device is in signal connection with a central processing unit.

6. A reaction viewing system according to claim 2, further comprising a charging device in communication with the first channel;

preferably, the feeding device is provided with a second sensor which is in signal connection with the central processing unit;

preferably, the charging device comprises a first driving device and one or more piston injectors, and the output end of the first driving device is connected with the pistons of the injectors;

preferably, the first driving device is in signal connection with a central processing unit.

7. A reaction observation system according to claim 2, further comprising a liquid storage device, wherein the liquid storage device comprises a liquid inlet and a liquid outlet, and the first channel is connected to the liquid inlet and/or the liquid outlet; preferably, the liquid storage device is also provided with a feed inlet;

preferably, the liquid storage device is provided with a third sensor, and the third sensor is in signal connection with the central processing unit.

8. A reaction observation system according to claim 1, further comprising signal transmission means, said signal transmission means being in signal communication with the central processing unit; or the reaction observation system also comprises a display screen which is in signal connection with the central processing unit.

9. A reaction observation method, comprising:

recording images of the reaction and reaction parameters;

sending the image of the reaction and the reaction parameters to a terminal;

preferably, the central processing unit records the image of the reaction through the digital display microscope;

the central processing unit records the reaction parameters through the first sensor;

the central processing unit transmits the image of the reaction to the terminal.

10. A reaction observation method according to claim 9, wherein the central processing unit receives an indication and controls the condition of the reaction in response to the indication.