CN112341870A - Coating material for enhancing ultrasonic mediated imaging - Google Patents
Coating material for enhancing ultrasonic mediated imaging Download PDFInfo
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- CN112341870A CN112341870A CN201910747568.2A CN201910747568A CN112341870A CN 112341870 A CN112341870 A CN 112341870A CN 201910747568 A CN201910747568 A CN 201910747568A CN 112341870 A CN112341870 A CN 112341870A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D123/00—Coating compositions based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Coating compositions based on derivatives of such polymers
- C09D123/02—Coating compositions based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
- C09D123/04—Homopolymers or copolymers of ethene
- C09D123/06—Polyethene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D163/00—Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/70—Additives characterised by shape, e.g. fibres, flakes or microspheres
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Abstract
The invention provides a coating material for enhancing ultrasonic mediated imaging, which displays clear images under an ultrasonic imager. Characterized by a polymer coating containing microbubbles or a polymer coating containing microbubbles and microparticles: wherein the diameter of the micro-bubble is 10nm-1 μm, and the gas in the micro-bubble can be oxygen, carbon dioxide, air, etc. Wherein the shape of the fine particles can be any shape, and the size is 10nm-1 μm. The polymer is organic substance, and can be polyether, polyester, polyamide, polyurethane, polysulfide rubber, epoxy resin, etc. The polymer coating has a thickness of between 1 and 150 μm and may be one or more layers. Compared with the prior art, the invention has the beneficial effects that: the coating material is characterized by containing micro-bubbles or micro-particles, so that out-of-phase interfaces are increased, the reflection sectional area of ultrasonic waves is increased, and ultrasonic reflection signals are enhanced, so that images displayed by the ultrasonic imaging device are clear and can be identified clearly.
Description
Technical Field
The invention relates to the field of medical treatment and health, in particular to a coating material for enhancing ultrasonic-mediated imaging.
Background
Compared with other imaging methods, the ultrasonic imaging has the incomparable advantages of good imaging effect, real-time imaging, simple and convenient operation, no radioactive pollution, relatively low price, wide application range, suitability for bedside and the like, thereby being one of the most widely applied imaging diagnosis means in clinic at present. Due to the real-time and convenient characteristics of ultrasonic imaging, the ultrasonic imaging is particularly suitable for being combined with various mediated treatment modes, such as needle knife therapy, double-cavity bronchial catheter intubation positioning, hepatorenal cyst interventional puncture, positioning of a living body sampler in a human body and the like. However, the ultrasonic imaging has its own disadvantages such as low sensitivity and the like, which make it have certain limitations in the above-mentioned treatment, for example, when the acupuncture angle is too large in the needle knife therapy, the needle knife is not well visualized in the ultrasonic guidance process; in the double-cavity bronchial catheter intubation positioning, the catheter dislocation rate is 13.3 percent; in the hepatorenal cyst interventional puncture, the pathological diagnosis accuracy rate of the common two-dimensional ultrasound guided puncture biopsy is 60%, and the living body sampler also has the problem of poor imaging in the ultrasound guidance.
Ultrasound Contrast Agents (UCAs). By changing the ultrasonic characteristics (such as a backscattering coefficient, an attenuation coefficient, a sound velocity, a nonlinear effect and the like) of the tissues, a strong scattering effect is generated on ultrasonic beams, so that echo signals of the positions are obviously enhanced, the gray level of an image on an acoustic image is enhanced, the aim of improving the contrast and the definition of the image is fulfilled, and a doctor can make more accurate judgment on diseases. Ultrasound contrast agents currently used in biomedical research and clinical practice are mostly micro (nano) bubbles containing different gases.
Some medical instruments related to enhancing the ultrasonic reflection capability have been proposed in the prior art, and CN201620763531.0 discloses an ultrasonic needle knife, wherein an ultrasonic high-echo reflection surface is arranged at a position three centimeters away from the top of the needle knife to the needle body and is designed as a spiral groove. The developing is clear when the treatment is carried out under the guidance of the ultrasound, and the precision and the safety in the treatment process are improved. CN201620724091.8 discloses a B ultrasonic guided nerve block pjncture needle, including integrated into one piece's needle end and needle body, the side of needle end is equipped with the line or the arch that is used for the supersound back wave, because line or protruding existence, makes the needle end show the image clearly under the B ultrasonic, and luminance and surrounding tissue contrast are great, and the recognition is easy, convenient observation.
The common features of the above solutions are: -
1. The ultrasonic enhancement surface is arranged at the top end or part of the needle body, but the ultrasonic enhancement surface is not arranged on the whole needle knife, which is not beneficial to capturing the whole environment of the puncture tool.
2. The groove, the lines, the bulges and the like can change the structure of the needle body, and can definitely cause certain damage to the structure of the needle body, so that the needle body has certain breaking possibility and causes problems to the safety of the human body.
Disclosure of Invention
The invention aims to avoid the defects of the prior art and provide a coating material for enhancing ultrasonic mediated imaging, which has clear display image, larger difference between brightness and surrounding tissues and clear identification under an ultrasonic imager.
The above object of the present invention is achieved by the following technical means.
A coating material for enhanced ultrasound-mediated imaging, characterized by a polymeric coating containing microbubbles or a polymeric coating containing microbubbles and microparticles.
Wherein the diameter of the micro-bubbles is between 10nm and 1 μm. The gas in the micro bubbles may be oxygen, carbon dioxide, air, nitrogen, fluorocarbon gas, etc
Wherein the size of the micro-particles is 10nm-1 μm. The shape of the fine particles may be spherical, rod-like, cake-like, spiral, rectangular, irregular, etc.
The polymer can be polyether, polyester, polyamide, polyurethane, polysulfide rubber, epoxy resin, acrylate, polysulfone, polyphenylene sulfide, polylactic acid, etc. The thickness of the polymer coating is between 1 and 150. mu.m. And the polymer coating may be one or more layers.
Compared with the prior art, the invention has the beneficial effects that:
the invention relates to a coating material for enhancing ultrasonic mediated imaging, which is characterized in that a polymer coating containing micro-bubbles or a polymer coating containing micro-bubbles and micro-particles increases out-of-phase interfaces due to the existence of the micro-bubbles or the micro-particles, and increases the reflection sectional area of ultrasonic waves, thereby enhancing ultrasonic reflection signals received by a probe, leading the ultrasonic reflection signals to be clear in image display under an ultrasonic imager, leading the difference between the brightness and surrounding tissues to be larger and leading the identification to be clear.
Drawings
The invention is further illustrated by means of the attached drawings, the content of which is not in any way limiting.
FIG. 1 is an unmodified conventional needle knife
FIG. 2 is a photomicrograph of a coated needle blade and its body portion coating in accordance with the present invention for enhanced ultrasound-mediated imaging
FIG. 3 is a graph showing the difference between an unmodified conventional needle blade and a coated needle blade for enhanced ultrasound-mediated imaging according to the present invention in ultrasound imaging
FIG. 4 is a coated biopsy needle of the present invention for enhanced ultrasound-mediated imaging
In fig. 1 to 4, the following are included:
1-needle end
2-needle body
3-needle seat
4-coating
FIG. 5 is a schematic diagram of ten exemplary polymer structures as coating materials for enhanced ultrasound-mediated imaging, including:
polyethylene glycol diglycidyl ether
(II) polyethylene terephthalate
③ Nylon 66
Polyurethane
Polysulfide rubber
Bisphenol A epoxy resin
Methacrylic acid methyl ester
(viii) polysulfone
Ninthly polyphenylene sulfide
Polylactic acid in R
Examples of tools or instruments capable of enhancing ultrasound-mediated imaging as described herein include, but are not limited to, medical instruments, such as permanently implanted or temporarily indwelling devices, such as catheters, stents, fillers and other accessories and tool surgical instruments, and needles, such as needle knives. However, as will be understood by those skilled in the art upon reading the present specification, the techniques described herein for enhancing ultrasonic visibility of a tool or instrument by enhancing the coating material for ultrasound mediated imaging are applicable to a variety of different fields and devices.
Detailed Description
The invention is further described with reference to the following examples
Example 1
As shown in figure 2, the coated material needle knife for enhancing ultrasound-mediated imaging comprises a needle end 1 and a needle body 2 which are integrally formed, wherein the needle end 1 is formed at one end of the needle body 2, a needle seat 3 is arranged at the other end of the needle body 2, and a coating 4 for enhancing an ultrasonic signal is arranged on the side surface of the needle end 3. The coating 4 is a polyethylene coating containing microbubbles with a diameter of 10nm to 1 μm and has a thickness of 0.1 mm. Due to the existence of the micro-bubbles, the out-phase interfaces are increased, the reflection sectional area of the ultrasonic wave is increased, and the ultrasonic reflection signals received by the probe are enhanced. The gas filled in the micro bubbles is air. And the polymer coating is one layer.
Compared with the prior art, the invention has the beneficial effects that:
the invention relates to a coating material for enhancing ultrasonic mediated imaging, which comprises a needle end 1 and a needle body 2 which are integrally formed, wherein the needle end 1 is formed at one end of the needle body 2, the other end of the needle body 2 is provided with a needle seat 3, and the side surface of the needle end 3 is provided with a coating 4 for enhancing ultrasonic signals. Wherein the coating 4 is a polymer coating containing microbubbles or a polymer coating containing microbubbles and microparticles. Due to the existence of micro-bubbles or micro-particles, the out-of-phase interfaces are increased, the reflection sectional area of ultrasonic waves is increased, and the ultrasonic reflection signals received by the probe are enhanced. The display image of the ultrasonic imaging device is clear, the difference between the brightness and the surrounding tissues is large, and the recognition is clear. As shown in fig. 3.
Example 2
As shown in figure 4, the coating material biopsy needle for enhancing ultrasonic mediated imaging comprises a needle end 1 and a needle body 2 which are integrally formed, wherein the needle end 1 is formed at one end of the needle body 2, the other end of the needle body 2 is provided with a needle base 3, and the side surface of the needle end 3 is provided with a coating 4 for enhancing ultrasonic signals. The coating 4 is an epoxy resin coating containing microbubbles with a diameter of 10nm to 1 μm and has a thickness of 0.1 mm. Mesoporous silica particles are added in the coating 4, due to the existence of microbubbles and particles, heterogeneous interfaces are increased, the reflection sectional area of ultrasonic waves is increased, and ultrasonic reflection signals received by the probe are enhanced. The gas filled in the micro bubbles is air. And the polymer coating is one layer.
Compared with the prior art, the invention has the beneficial effects that:
the invention relates to a coating material for enhancing ultrasonic mediated imaging, which comprises a needle end 1 and a needle body 2 which are integrally formed, wherein the needle end 1 is formed at one end of the needle body 2, the other end of the needle body 2 is provided with a needle seat 3, and the side surface of the needle end 3 is provided with a coating 4 for enhancing ultrasonic signals. Wherein the coating 4 is a polymer coating containing microbubbles or a polymer coating containing microbubbles and microparticles. Due to the existence of micro-bubbles or micro-particles, the out-of-phase interfaces are increased, the reflection sectional area of ultrasonic waves is increased, and the ultrasonic reflection signals received by the probe are enhanced. The display image of the ultrasonic imaging device is clear, the difference between the brightness and the surrounding tissues is large, and the recognition is clear.
Claims (11)
1. The invention relates to a coating material for enhancing ultrasonic mediated imaging, which is characterized in that a polymer coating containing micro-bubbles or a polymer coating containing micro-bubbles and micro-particles increases out-of-phase interfaces due to the existence of the micro-bubbles or the micro-particles, and increases the reflection sectional area of ultrasonic waves, thereby enhancing ultrasonic reflection signals received by a probe, leading the ultrasonic reflection signals to be clear in image display under an ultrasonic imager, leading the difference between the brightness and surrounding tissues to be larger and leading the identification to be clear.
A coating material for enhanced ultrasound-mediated imaging, characterized by a polymeric coating containing microbubbles or a polymeric coating containing microbubbles and microparticles.
2. The coating material of claim 1, wherein the microbubbles and microparticles are uniformly dispersed in the polymer coating.
3. The coating material of claim 1, wherein the microbubbles and microparticles are within a polymer coating.
4. The coating material of claim 1, wherein the surface of the coating material is smooth and flat.
5. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the diameter of the micro-bubbles is between 10nm and 1 μm.
6. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the gas in the microbubbles may be oxygen, carbon dioxide, air, nitrogen, fluorocarbon-based gas, or the like.
7. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the size of the micro-particles is between 10nm and 1 mu m.
8. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the shape of the fine particles may be spherical, rod-like, cake-like, spiral, rectangular parallelepiped, irregular, etc.
9. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the polymer may be polyether, polyester, polyamide, polyurethane, polysulfide rubber, epoxy resin, acrylate, polysulfone, polyphenylene sulfide, polylactic acid, etc.
10. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the thickness of the polymer coating is between 1 and 150 μm.
11. The coating material for enhanced ultrasound-mediated imaging according to claim 1, wherein: the polymer coating may be one or more layers. Examples of tools or instruments capable of enhancing ultrasound-mediated imaging as described herein include, but are not limited to, medical instruments, such as permanently implanted or temporarily indwelling devices, such as catheters, stents, fillers and other accessories and tool surgical instruments, and needles, such as needle knives. However, as will be understood by those skilled in the art upon reading this disclosure, the techniques described herein for enhancing ultrasonic visibility of a tool or instrument by enhancing the coating material for ultrasound mediated imaging are applicable to a variety of different fields and devices.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910747568.2A CN112341870A (en) | 2019-08-08 | 2019-08-08 | Coating material for enhancing ultrasonic mediated imaging |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910747568.2A CN112341870A (en) | 2019-08-08 | 2019-08-08 | Coating material for enhancing ultrasonic mediated imaging |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136285A (en) * | 1993-09-03 | 1996-11-20 | 奈科姆成像有限公司 | Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imageing |
| CN1236322A (en) * | 1996-11-06 | 1999-11-24 | 斯蒂斯生物聚合物公司 | Echogenic coating containing gaseous spaces for ultrasonography |
| CN103260532A (en) * | 2010-10-18 | 2013-08-21 | 卡尔迪欧索尼克有限公司 | Ultrasound emission element |
| CN105007957A (en) * | 2012-10-31 | 2015-10-28 | 恩克普森有限公司 | Medical devices with coatings for enhanced echogenicity |
| CN106470712A (en) * | 2014-04-30 | 2017-03-01 | 恩克普森有限公司 | There is the medical treatment device of the non-uniform coating for strengthening echogenicity |
-
2019
- 2019-08-08 CN CN201910747568.2A patent/CN112341870A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136285A (en) * | 1993-09-03 | 1996-11-20 | 奈科姆成像有限公司 | Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imageing |
| CN1236322A (en) * | 1996-11-06 | 1999-11-24 | 斯蒂斯生物聚合物公司 | Echogenic coating containing gaseous spaces for ultrasonography |
| CN103260532A (en) * | 2010-10-18 | 2013-08-21 | 卡尔迪欧索尼克有限公司 | Ultrasound emission element |
| CN105007957A (en) * | 2012-10-31 | 2015-10-28 | 恩克普森有限公司 | Medical devices with coatings for enhanced echogenicity |
| CN106470712A (en) * | 2014-04-30 | 2017-03-01 | 恩克普森有限公司 | There is the medical treatment device of the non-uniform coating for strengthening echogenicity |
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