CN112336736A - 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 - Google Patents

开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 Download PDF

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Publication number
CN112336736A
CN112336736A CN202010760162.0A CN202010760162A CN112336736A CN 112336736 A CN112336736 A CN 112336736A CN 202010760162 A CN202010760162 A CN 202010760162A CN 112336736 A CN112336736 A CN 112336736A
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sdg
cells
dna
radiation
induced
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Chinese (zh)
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迈尔波·赫里斯托费多-所罗米多
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN202010760162.0A 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途 Pending CN112336736A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US62/005,330 2014-05-30
US201562101296P 2015-01-08 2015-01-08
US62/101,296 2015-01-08
CN201580028874.0A CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

Related Parent Applications (1)

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CN201580028874.0A Division CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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CN112336736A true CN112336736A (zh) 2021-02-09

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CN202010760162.0A Pending CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途
CN201580028874.0A Pending CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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CN201580028874.0A Pending CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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EP (1) EP3148560A4 (https=)
JP (2) JP2017520620A (https=)
KR (1) KR20170010019A (https=)
CN (2) CN112336736A (https=)
AU (2) AU2015266614A1 (https=)
CA (1) CA2950744A1 (https=)
IL (1) IL249219A0 (https=)
MA (1) MA39899A (https=)
WO (1) WO2015184441A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11071746B2 (en) 2016-06-07 2021-07-27 The Trustees Of The University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
EP3606325B1 (en) * 2017-04-03 2024-09-04 Gusto Global, LLC Rational design of microbial-based biotherapeutics
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy
EP3687545A4 (en) * 2017-09-27 2021-06-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
WO2020046476A1 (en) * 2018-08-31 2020-03-05 Innophos, Inc. Botanical antioxidants
CN121094806B (zh) * 2025-11-07 2026-02-24 深圳鼎智通讯股份有限公司 一种Android SoftPOS可信应用方法以及应用系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164A1 (en) * 1999-06-30 2000-12-30 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
CN101759731A (zh) * 2008-12-25 2010-06-30 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

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Publication number Priority date Publication date Assignee Title
CN100365005C (zh) * 2006-03-02 2008-01-30 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
US20070293458A1 (en) * 2006-06-16 2007-12-20 Ip-6 Research Inc. Prevention of nuclear, solar, and other radiation-induced tissue damage
AU2009279676C1 (en) * 2008-08-07 2015-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Radioprotectants targeting thrombospondin-1 and CD47
TR201815423T4 (tr) * 2013-06-10 2018-11-21 Scripps Research Inst (s,s)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d ve (r,r)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d'i̇n hazirlanmasi.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164A1 (en) * 1999-06-30 2000-12-30 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof
CN101759731A (zh) * 2008-12-25 2010-06-30 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OM P. MISHRA ET AL.: "Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)" *
张腾;张崇禧;黄建军;: "亚麻籽水解物化学成分研究及SDG含量测定" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

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Publication number Publication date
CN107155304A (zh) 2017-09-12
WO2015184441A3 (en) 2016-03-10
CA2950744A1 (en) 2015-12-03
KR20170010019A (ko) 2017-01-25
IL249219A0 (en) 2017-02-28
AU2020270469A1 (en) 2020-12-17
EP3148560A4 (en) 2018-04-25
JP2017520620A (ja) 2017-07-27
WO2015184441A9 (en) 2016-01-21
WO2015184441A2 (en) 2015-12-03
AU2015266614A1 (en) 2016-12-15
MA39899A (fr) 2021-05-26
JP2020121987A (ja) 2020-08-13
EP3148560A2 (en) 2017-04-05

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Application publication date: 20210209