CN112336633B - Dental bonding pretreatment system based on copper and zinc ions and application - Google Patents

Abstract

The invention provides a dental bonding pretreatment system based on copper and zinc ions and application thereof. Copper/zinc ions and side chains such as carboxyl, hydroxyl, carbonyl, sulfydryl and the like in the demineralized dentin organic matrix are bonded to form copper/zinc-containing insoluble nanoparticles, so that the dentin organic matrix is endowed with antibacterial performance, the strength and the specific surface area of the demineralized dentin matrix are obviously increased, the three-dimensional network of the demineralized dentin organic matrix can resist dehydration shrinkage, higher compatibility is obtained between a bonding interface and a bonding monomer, the penetration and uniform distribution of a bonding agent are promoted, and the bonding strength and the bonding durability are improved. The surface of the demineralized dentin matrix treated by the pretreatment agent prepared by the pretreatment system can obtain higher bonding strength and durability no matter the tooth surface is wet or dry when the adhesive is coated, and the technical sensitivity of clinical operation is greatly reduced.

Description

Dental bonding pretreatment system based on copper and zinc ions and application

Technical Field

The invention belongs to the field of dental bonding repair materials, relates to a dental bonding pretreatment system based on copper and zinc ions and application thereof, and mainly relates to a dental bonding pretreatment auxiliary agent based on copper and zinc ions, which is used for a dental surface pretreatment process for preventing secondary caries, improving bonding effect and reducing bonding operation technology sensitivity.

Background

In dental medicine, the restorative treatment of a tooth defect takes a large part of the time of a doctor, and the use of an adhesive material cannot be separated whether the tooth is directly restored or indirectly restored.

The firm and durable adhesion between the dental tissue and the adhesive material is critical to the success of the repair. The dentin is one of bonding interfaces with complex structures, and the surface treatment mode of the dentin determines the bonding strength and the bonding durability, so that the clinical repairing effect is directly influenced.

Currently, the clinical dentin adhesion technique is a wet adhesion technique, i.e. using acid on the dentin surface to remove surface several microns of mineral matter, exposing the organic matrix network and keeping it in a wet state, and the adhesive penetrates into the three-dimensional network to form a mechanically interpenetrating hybrid layer with the dentin organic matrix.

Based on the wet bonding technology, the dentin bonding obtains good bonding strength, and lays the foundation of dentin bonding.

However, although the wet adhesion technique achieves better initial adhesion strength, the non-collagen in the demineralized dentin organic matrix contains a large amount of side chain groups with high reactivity such as carboxyl, hydroxyl, carbonyl, sulfydryl and the like, so that the non-collagen has stronger hydration capability, under the wet adhesion environment, the non-collagen forms hydrogel-like structures on the surface of the dentin collagen fibers, and the structures form structures similar to molecular sieves, thereby seriously hindering the penetration and uniform distribution of key hydrophobic components of the adhesive in the demineralized dentin collagen fiber network, filling defects in the formed tooth body-adhesive bonding interface-hybrid layer, generating various problems when being used in a complex oral environment for a long time, and often causing the falling-off of the prosthesis.

Meanwhile, in a long-term process, the bonding interface is exposed in the environment of the oral cavity which is full of bacteria for a long time, and the nano leakage at the edge of the prosthesis provides a channel for the bacteria and metabolites thereof to further attack the residual dental tissues, so that the nano leakage becomes a hidden trouble of secondary caries after bonding.

Furthermore, in the wet bonding technique, there is no standard for the degree of wetting of the dental surface to which the adhesive is applied, and excessively wet or excessively dry dental surfaces affect the bonding effect, and have great technical sensitivity.

Therefore, in order to improve the adhesion durability and prevent secondary caries, development of a dental pretreatment system for oral adhesion having antibacterial properties in conformity with the dentin characteristics is strongly required.

Disclosure of Invention

The invention aims to provide a dental bonding pretreatment system based on copper and zinc ions, which comprises a one-component system, a two-component system or a three-component system.

The binary system is a solution (A) which is a soluble copper salt solution, a soluble zinc salt solution and a soluble copper/zinc mixed solution thereof.

Wherein the soluble copper salt solution is a soluble copper salt solution with a mass fraction of 0.0001% to a saturated concentration, and includes but is not limited to copper fluoride aqueous solution, copper chloride aqueous solution, copper sulfate aqueous solution, copper nitrate aqueous solution, and a mixed solution of the above 2 solutions or more. The optimal copper ion concentration is 0.002-0.1 percent by mass.

The soluble zinc salt solution can be 0.0001 wt% to saturation concentration, and includes but is not limited to zinc fluoride aqueous solution, zinc chloride aqueous solution, zinc sulfate aqueous solution, zinc nitrate aqueous solution, and mixed solution of the above 2 or more solutions. The optimal zinc ion concentration is 0.002-0.1% by mass fraction.

Wherein the soluble copper/zinc mixed solution is a mixed solution of any one or more soluble copper salt solutions and any one or more soluble zinc salt solutions.

The binary system consists of a solution (A) and a solution (B), wherein the solution (A) is defined as the solution (A) in the unitary system, and the solution (B) is a soluble solution which can react with the solution (A) to generate insoluble precipitates.

The solution (B) is soluble carbonate, soluble sulfide, soluble selenide, soluble telluride, soluble phosphate, soluble alkali solution or the mixed solution of the two or more solutions.

Wherein the concentration of the soluble carbonate is 0.0001 percent by mass to the saturated concentration, and the soluble carbonate comprises but is not limited to lithium carbonate aqueous solution, sodium carbonate aqueous solution, potassium carbonate aqueous solution, ammonium carbonate aqueous solution, and mixed solution of one or more of the above solutions. The optimal concentration is 0.002-0.1% by mass fraction.

The concentration of the soluble sulfide is 0.0001 percent by mass to saturation concentration, and the soluble sulfide comprises but is not limited to lithium sulfide aqueous solution, sodium sulfide aqueous solution, potassium sulfide aqueous solution, ammonium sulfide aqueous solution, selenium sulfide aqueous solution, tellurium sulfide aqueous solution and one or more of the mixed solution of the lithium sulfide aqueous solution, the sodium sulfide aqueous solution, the potassium sulfide aqueous solution, the ammonium sulfide aqueous solution, the selenium sulfide aqueous solution and the tellurium sulfide aqueous solution. The optimal concentration is 0.002-0.1% by mass fraction.

Wherein the concentration of the soluble selenide is 0.0001 percent by mass to the saturated concentration, and the soluble selenide comprises but is not limited to lithium selenide aqueous solution, sodium selenide aqueous solution, potassium selenide aqueous solution, sodium selenate aqueous solution, sodium selenite aqueous solution, and one or more of the mixed solution of the above solutions. The optimal concentration is 0.002-0.1% by mass fraction.

The concentration of the soluble telluride is 0.0001 percent by mass to the saturated concentration, and the soluble telluride comprises but is not limited to lithium telluride aqueous solution, sodium telluride aqueous solution, potassium telluride aqueous solution, sodium tellurite aqueous solution and one or more of the mixed solution of the lithium telluride aqueous solution, the sodium tellurite aqueous solution and the sodium tellurite aqueous solution. The optimal concentration is 0.002-0.1% by mass fraction.

The concentration of the soluble phosphate is 0.0001 percent by mass to the saturated concentration, and the soluble phosphate comprises but is not limited to lithium monohydrogen phosphate, sodium monohydrogen phosphate aqueous solution, potassium monohydrogen phosphate aqueous solution, sodium dihydrogen phosphate aqueous solution, potassium dihydrogen phosphate aqueous solution, lithium phosphate, potassium phosphate, sodium phosphate, ammonium phosphate, and one or more of the mixed solution of the above solutions. The optimal concentration is 0.002-0.1% by mass fraction.

Wherein the concentration of the soluble alkali solution is 0.0001 percent by mass to the saturated concentration, and the soluble alkali solution comprises but is not limited to ammonia water, sodium hydroxide, potassium hydroxide, calcium hydroxide, barium hydroxide, strontium hydroxide and a mixed solution of one or more of the solutions. The optimal concentration is 0.002-0.1% by mass fraction.

The ternary system consists of a solution (A), a solution (B) and a solution (C), wherein the definition of the solution (A) is the same as that of the solution (A) of the unitary system, the definition of the solution (B) is the same as that of the solution (B) of the binary system, and the solution (C) is an organic monomer compound which can generate chemical chelation with copper ions/zinc ions or precipitates thereof.

In a ternary system dental bonding pretreatment system, solution (C) is an organic monomer compound capable of chemically interacting with copper/zinc ions, including but not limited to dihydrogen methacrylate phosphate 2-hydroxyethyl (HEMA-phosphate, C6H11O6P), 10-methacryloxy decyl phosphate (10-MDP, C14H27O6P), di (methacryloxy ethyl) hydrogen phosphate (Bis-MEP, C5H9O6P), dipentaerythritol pentaacrylate phosphate (PENTA, C24H33O15P), 2-methacryloxy ethyl Phenyl hydrogen phosphate (Phenyl-P, C12H14O6P), n-dodecyl dihydrogen phosphate (C12H 27O4P), ethyl dihydrogen phosphate (C2H 7O4P), Polyacrylic acid (C3H 4O2N), and a solvent for dissolving the organic monomer compound including, but not limited to, water, ethanol, acetone, or any mixture thereof.

Another object of the present invention is to provide the use of the dental adhesion pretreatment system for preparing a dental adhesion pretreatment agent. The solution (A), the solution (B) and the solution (C) in the dental adhesive pretreatment agent are packaged separately. The auxiliary agent has a bonding effect with side chains such as carboxyl, hydroxyl, carbonyl, sulfydryl and the like in the demineralized dentin organic matrix through copper/zinc ions, the bonded copper/zinc ions or copper/zinc-containing insoluble nanoparticles deposited based on the in-situ induction of the copper/zinc ions endow the demineralized dentin organic matrix with antibacterial performance, the strength and the specific surface area of the demineralized dentin matrix are obviously increased, a three-dimensional network of the demineralized dentin organic matrix can resist dehydration shrinkage, a bonding interface and a bonding monomer have higher compatibility, the penetration and uniform distribution of a bonding agent are promoted, and the bonding strength and the bonding durability are obviously improved.

The mono-, binary-, or ternary system provided by the invention is applied after clinical acid treatment of the tooth surface and before application of the adhesive.

When a one-component system is used for the dental adhesive pretreatment, the solution (A) can be applied several times.

When the binary system is used for dental adhesion pretreatment, the solution (A) is coated firstly, then the solution (B) is coated, and then the adhesive is coated for dental adhesion.

When the ternary system is used for dental adhesion pretreatment, the solution (A) is coated firstly, then the solution (B) is coated, after water vapor washing, the solution (C) is coated, and then the adhesive is coated for dental adhesion.

When a binary system or a ternary system is used for dental adhesion pretreatment, the solution (A) and the solution (B) can be coated for multiple times in a circulating manner.

After treating the demineralized dentin surface with a mono-, binary-or ternary system, the tooth surface can be either kept wet or dried before the adhesive is applied.

When the one-component system, the two-component system or the three-component system is used for the dental adhesion pretreatment, the applied adhesive can be all existing dentin adhesives.

When a monobasic system, a binary system or a ternary system is used for dental adhesion pretreatment, the content of copper/zinc elements in the organic matrix on the surface of the dentin is increased.

When a unitary system, a binary system or a ternary system is used for dental adhesion pretreatment, the polarity of the surface of the dentin organic matrix is reduced, the surface potential is increased, the hydration capability is weakened, and the interface compatibility of the demineralized dentin organic matrix and a key hydrophobic adhesion component in the adhesive is greatly improved.

When a unitary system, a binary system or a ternary system is used for dental adhesion pretreatment, the surface of the demineralized dentin organic matrix has antibacterial performance.

When a unitary system, a binary system or a ternary system is used for dental adhesion pretreatment, the surface area of the dentin organic matrix is increased, the rigidity of the demineralized dentin matrix is increased, and the shrinkage of the dentin organic matrix caused by drying can be resisted, so that the dentin adhesion is free from dependence on water, and the technical sensitivity of clinical operation of the dentin adhesion is reduced.

When a unitary system, a binary system or a ternary system is used for dental bonding pretreatment, the interfacial compatibility of the demineralized dentin organic matrix and the adhesive is obviously improved, the redistribution phenomenon of key hydrophobic components of the adhesive between the adhesive layer and the demineralized dentin is greatly relieved, the permeability in the demineralized dentin layer is increased, the content is improved, the distribution is more uniform, the clinical bonding effect of various adhesives can be improved, and the dependency on the technical level of doctors and the types of the adhesives is reduced.

Compared with the prior wet bonding technology, the invention is characterized in that after acid etching demineralization treatment and before applying the adhesive, the surface of a tooth body is pretreated, and the demineralized dentin organic matrix is endowed with antibacterial performance through the interaction of copper/zinc ions and high-reactivity side chain groups such as carboxyl, hydroxyl, carbonyl, sulfydryl and the like in the demineralized dentin organic matrix. The dental bonding pretreatment system based on copper and zinc ions is used for dental restoration bonding, reduces the technical sensitivity of dental bonding, prevents secondary caries, obtains high bonding force and improves the bonding durability.

The copper/zinc-containing nano-particles are deposited in situ by a binary system and a ternary system, the hydration capacity of the surface of the demineralized dentin matrix is eliminated, the interface compatibility of the demineralized dentin matrix and key hydrophobic components of the adhesive is improved, the surface area of the demineralized dentin matrix is increased, the rigidity of the demineralized organic matrix is enhanced, a porous open structure can be kept under the condition of water evaporation and drying, the dependence of a tooth adhesion operation technology on water is reduced, and the durability of adhesion repair is greatly improved

Drawings

FIG. 1 shows the surface topography of the teeth according to examples one to three.

FIG. 2 is the observation results of the tooth surface spectrometer of the first to third embodiments.

FIG. 3 shows the results of tensile strength of Single Bond 2 adhesives of twelve to fourteen examples.

FIG. 4 shows the surface topography of the teeth according to examples one, five and six.

FIG. 5 shows the results of tensile strength of Single Bond 2 adhesives of twelve, fifteen, and sixteen examples.

FIG. 6 shows the results of tensile strength of Single Bond 2 adhesives in twelve, seventeen and eighteen examples.

Detailed Description

The present invention is further illustrated by the following examples, which are included merely to better illustrate the features of the invention and are not to be construed as limiting the scope of the invention as claimed.

Example one

And (3) rinsing with water vapor after the phosphoric acid etching treatment on the surface of the dentin, and keeping the surface wet or drying the surface by blowing.

Example two

And (3) rinsing the dentin surface with water vapor after phosphoric acid etching treatment, coating 20 mul of solution (A) with 0.25 percent of copper sulfate aqueous solution by mass percent on the surface for 20s, rinsing with water vapor, and keeping the surface wet or drying the surface dry.

EXAMPLE III

After the dentin surface is treated by phosphoric acid etching, the dentin surface is washed by water vapor, 20 mul of solution (A) which is 0.25 percent of copper sulfate aqueous solution in mass fraction is coated on the dentin surface for 20s, and then 20 mul of solution (B) is coated: and (3) washing the sodium sulfide aqueous solution with the mass fraction of 0.078% for 20s with water vapor, and keeping the surface wet or drying the surface by blowing.

Example four

After the phosphoric acid etching treatment of the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, and the surface is kept wet or is dried by blowing.

EXAMPLE five

And (3) rinsing the dentin surface with water vapor after phosphoric acid etching treatment, coating 20 mul of solution (A) with 0.13 percent of zinc chloride aqueous solution by mass percent on the surface for 20s, rinsing with water vapor, and keeping the surface wet or drying the surface by blowing.

EXAMPLE six

And (3) rinsing with water vapor after the phosphoric acid etching treatment of the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.13% of zinc chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution for 20s, rinsing with water vapor, and keeping the surface wet or drying the surface by blowing.

EXAMPLE seven

After the phosphoric acid etching treatment of the dentin surface, the dentin surface is washed by water vapor, and 20 mul of solution (A) is coated on the surface, wherein the mass fraction of the solution is 0.25 percent of copper sulfate aqueous solution and the mass fraction of the solution is 0.13 percent of zinc chloride aqueous solution, the weight ratio of the solution is 1: 1, mixing the solution for 20s, washing with water vapor, and keeping the surface wet or drying the surface by blowing.

Example eight

After the phosphoric acid etching treatment of the dentin surface, the dentin surface is washed by water vapor, and 20 mul of solution (A) is coated on the surface, wherein the mass fraction of the solution is 0.25 percent of copper sulfate aqueous solution and the mass fraction of the solution is 0.13 percent of zinc chloride aqueous solution, the weight ratio of the solution is 1: 1 solution (B) 20. mu.l of a 0.078% by weight aqueous sodium sulfide solution (B) are then applied for 20s, rinsed with water vapor and the surface is left wet or blown dry.

Example nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, and the surface is kept wet or is dried by blowing.

Example ten

The surface morphology of the teeth of examples one to three, five and six was observed by using a field emission scanning electron microscope, and the results are shown in fig. 1 and 4. The in-situ deposited nanoparticles are in-situ deposited between and within the dentin collagen fibers, intertwining with the dentin organic matrix.

EXAMPLE eleven

The distribution of elements on the surfaces of the teeth of the first to third, fifth and sixth examples is observed by an energy spectrometer, and the result is shown in fig. 2. Dental organic matrix the copper/zinc content increases at the surface after treatment with the pretreatment composition of the present invention.

Example twelve

And (3) rinsing the dentin surface with water vapor after phosphoric acid etching treatment, keeping the surface wet or drying the surface, coating a Single Bond 2 adhesive, and performing light curing to Bond the restoration.

EXAMPLE thirteen

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) of copper sulfate aqueous solution with the mass fraction of 0.25% is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet or dried by blowing, or Single Bond 2 adhesive is coated, illumination curing is carried out, and prosthesis bonding is carried out.

Example fourteen

After the dentin surface is treated by phosphoric acid etching, the dentin surface is washed by water vapor, 20 mul of solution (A) which is 0.25 percent of copper sulfate aqueous solution in mass fraction is coated on the dentin surface for 20s, and then 20 mul of solution (B) is coated: and (3) washing the aqueous solution of sodium sulfide with the mass fraction of 0.078% for 20s with water vapor, keeping the surface wet or drying the surface by blowing, coating a Single Bond 2 adhesive, and performing light curing to Bond the prosthesis.

Example fifteen

And (2) rinsing with water vapor after phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) of zinc chloride aqueous solution with the mass fraction of 0.13% on the surface for 20s, rinsing with water vapor, keeping the surface wet or drying the surface by blowing, coating a Single Bond 2 adhesive, curing by illumination, and adhering the prosthesis.

Example sixteen

And (2) rinsing with water vapor after the phosphoric acid etching treatment of the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.13% of zinc chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution for 20s, rinsing with water vapor, keeping the surface wet or drying the surface by blowing, coating a Single Bond 2 adhesive, and performing light curing to Bond the restoration.

Example seventeen

After the phosphoric acid etching treatment of the dentin surface, the dentin surface is washed by water vapor, and 20 mul of solution (A) is coated on the surface, wherein the mass fraction of the solution is 0.25 percent of copper sulfate aqueous solution and the mass fraction of the solution is 0.13 percent of zinc chloride aqueous solution, the weight ratio of the solution is 1: 1, mixing the solution for 20s, washing with water vapor, keeping the surface wet or drying the surface by blowing, coating a Single Bond 2 adhesive, and curing by illumination to Bond the prosthesis.

EXAMPLE eighteen

After the phosphoric acid etching treatment of the dentin surface, the dentin surface is washed by water vapor, and 20 mul of solution (A) is coated on the surface, wherein the mass fraction of the solution is 0.25 percent of copper sulfate aqueous solution and the mass fraction of the solution is 0.13 percent of zinc chloride aqueous solution, the weight ratio of the solution is 1: 1, mixing the solution for 20s, then coating 20 mul of solution (B)0.078 wt% sodium sulfide aqueous solution for 20s, washing with water vapor, keeping the surface wet or drying the surface by blowing, coating a Single Bond 2 adhesive, curing by illumination, and carrying out prosthesis adhesion.

Example nineteen

The samples in the twelve to eighteen examples were cut along the direction perpendicular to the bonding interface of the long axis of dentin under the cooling of running water by a slow cutting machine to prepare resin-dentin strip samples with bonding surfaces of 1 mm × 1 mm, and the resin-dentin strip samples were subjected to a micro-tensile test by a micro-tensile tester until the samples broke, and the load measured by the micro-tensile tester when the samples broke was recorded. The interfacial width of the sample was measured and the cross-sectional area micro-tensile strength of the sample was calculated. The results are shown in FIGS. 3, 5 and 6. After the dental bonding pretreatment system is used, the bonding strength at the dentin-resin interface is improved and the durability is enhanced in two adhesive systems, and even under the condition of blow drying, the strength is still high and the durability is still strong.

Example twenty

After the dentin surface is treated by phosphoric acid etching, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent by weight of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example twenty one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the restoration.

Example twenty two

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light irradiation curing is carried out to bond the restoration.

Example twenty three

After the dentin surface is treated by phosphoric acid etching, washing with water vapor, coating 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution for 20s, then coating 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution for 20s, washing with water vapor, coating solution (A) + solution (B) + washing to form a cycle, repeating the cycle for 3 times, drying the surface, coating 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution, coating a Spectrum adhesive, curing by illumination, and adhering a restoration.

Example twenty-four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, Single Bond 2 adhesive is coated, and illumination curing is carried out to Bond the restoration.

Example twenty-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, Single Bond 2 adhesive is coated, and illumination curing is carried out to Bond the restoration.

Example twenty-six

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

Practice of twenty-seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.25 percent of copper sulfate aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and light curing is carried out to Bond the restoration.

Example twenty-eight

And (2) carrying out water vapor washing after the phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) with 0.013 percent of copper chloride aqueous solution for 20s, carrying out water vapor washing, keeping the surface wet, coating a Spectrum adhesive, and carrying out light curing to bond the prosthesis.

Example twenty-nine

And (2) carrying out water vapor washing after the phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) with 0.013 percent of copper chloride aqueous solution for 20s, carrying out water vapor washing, drying the surface, coating a Spectrum adhesive, and carrying out light curing to bond the prosthesis.

Example thirty

And (2) carrying out water vapor washing after the phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) with 0.013 percent of copper chloride aqueous solution for 20s, carrying out water vapor washing, keeping the surface wet, coating a Single Bond 2 adhesive, and carrying out light curing to Bond the prosthesis.

Example thirty one

And (2) rinsing with water vapor after phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) with 0.013 percent of copper chloride aqueous solution for 20s, rinsing with water vapor, drying the surface, coating a Single Bond 2 adhesive, and curing by illumination to Bond the prosthesis.

Example thirty-two

And (3) rinsing with water vapor after the phosphoric acid etching treatment of the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution for 20s, rinsing with water vapor, keeping the surface wet, coating a Spectrum adhesive, curing by illumination, and adhering the restoration.

Example thirty-three

And (3) rinsing with water vapor after the phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution for 20s, rinsing with water vapor, drying the surface, coating a Spectrum adhesive, and curing by illumination to bond the restoration.

Example thirty-four

And (3) rinsing with water vapor after the phosphoric acid etching treatment of the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution for 20s, then coating 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution for 20s, rinsing with water vapor, keeping the surface wet, coating a Single Bond 2 adhesive, and curing by illumination to Bond the restoration.

Example thirty-five

And (3) rinsing with water vapor after the phosphoric acid etching treatment of the surface of the dentin, coating 20 mul of solution (A) with the mass fraction of 0.013 percent of copper chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution for 20s, rinsing with water vapor, drying the surface, coating a Single Bond 2 adhesive, and curing by illumination to Bond the restoration.

Example thirty-six

After the phosphoric acid etching treatment of the dentin surface, washing with water vapor, coating 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution for 20s on the surface, then coating 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution for 20s, washing with water vapor, repeating the cycle of coating solution (A) + solution (B) + washing for 3 times, keeping the surface wet, coating a Spectrum adhesive, curing by light irradiation, and adhering the prosthesis.

Example thirty-seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of water solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide water solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for one cycle, the cycle is repeated for 3 times, the surface is dried, a Spectrum adhesive is coated, and illumination curing is carried out to bond the prosthesis.

Example thirty-eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example thirty-nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example forty

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and illumination curing is carried out to bond the prosthesis.

Example forty one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.004% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the prosthesis.

Example forty two

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light irradiation curing is carried out to bond the restoration.

Example forty-three

And (3) carrying out water vapor washing after the phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of a copper chloride aqueous solution with the mass fraction of 0.013% for 20s on the surface, then coating 20 mul of a solution (B) with the mass fraction of 0.008% for 20s of a sodium hydroxide aqueous solution, carrying out water vapor washing, repeating the cycle of coating solution (A) + solution (B) + washing for 3 times, drying the surface, coating 20 mul of a solution (C) with the mass fraction of 15% of a 10-MDP ethanol solution, coating a Spectrum adhesive, and carrying out light curing to bond the restoration.

Example forty-four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example forty-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, then Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example forty-six

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

Example forty-seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% of copper chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

Example forty-eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.13 percent of zinc chloride aqueous solution is coated for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example forty-nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example fifty

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light curing is carried out to carry out prosthesis adhesion.

Example fifty one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light curing is carried out to bond the restoration.

Example fifty two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.13 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.078 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, Single Bond 2 adhesive is coated, and illumination curing is carried out to Bond the prosthesis.

Example fifty three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example fifty four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to Bond the prosthesis.

Example fifty five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.13% is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 0.078% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

Example fifty six

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) of zinc sulfate aqueous solution with the mass fraction of 0.16% is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example fifty seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) of zinc sulfate aqueous solution with the mass fraction of 0.16% is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, Spectrum adhesive is coated, and illumination curing is carried out to bond the prosthesis.

Example fifty eight

And (2) rinsing with water vapor after phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) 0.16 mass percent of zinc sulfate aqueous solution on the surface for 20s, rinsing with water vapor, keeping the surface wet, coating a Single Bond 2 adhesive, and curing by illumination to Bond the restoration.

Example fifty nine

And (2) rinsing with water vapor after phosphoric acid etching treatment on the surface of the dentin, coating 20 mul of solution (A) of zinc sulfate aqueous solution with the mass fraction of 0.16% on the surface for 20s, rinsing with water vapor, drying the surface, coating a Single Bond 2 adhesive, and curing by illumination to Bond the restoration.

Example sixty

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example sixty one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, surface drying is carried out, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example sixty-two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example sixty-three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, surface drying is carried out, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example sixty-four

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example sixty-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example sixty-six

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example sixty-seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example sixty-eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the prosthesis.

Example sixty-nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the prosthesis.

Example seventy

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light curing is carried out to carry out prosthesis adhesion.

Example seventy one

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light curing is carried out to carry out prosthesis bonding.

Example seventy-two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% zinc chloride water solution with the mass fraction of 20s is coated on the surface, 20 mul of solution (B) with the mass fraction of 0.008% sodium hydroxide water solution with the mass fraction of 20s is coated on the surface, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated on the surface, and illumination curing is carried out to carry out prosthesis adhesion.

Example seventy-three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008 percent of sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example seventy-four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and light irradiation curing is carried out to carry out prosthesis bonding.

Example seventy-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.013% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.008% sodium hydroxide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and light curing is carried out to carry out prosthesis bonding.

Example seventy-six

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example seventy-seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing, surface drying, coating of Spectrum adhesive, illumination curing and prosthesis bonding are carried out.

Example seventy-eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example seventy nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, surface drying is carried out, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example eighty

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example eighty one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example eighty two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example eighty three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example eighty four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated for 20s, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example eighty-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15 percent-MDP ethanol solution is coated on the surface, then Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example eighty six

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated, a Spectrum adhesive is coated, and light curing is carried out to carry out the adhesion restoration.

Example eighty seven

After the phosphoric acid etching treatment of the dentin surface, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated, a Spectrum adhesive is coated, and light curing is carried out to bond the restoration.

Example eighty eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 0.0001 percent and the water soluble mass fraction of zinc chloride for 20s is coated on the surface, 20 mul of solution (B) with the mass fraction of 0.0008 percent and the water solution of sodium sulfide for 20s is coated on the surface, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent and 10-MDP ethanol solution is coated on the surface, and then Single Bond 2 adhesive is coated and cured by illumination, so that prosthesis bonding is carried out.

Example eighty nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, then Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

EXAMPLE ninety

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

EXAMPLE ninety one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 0.0001 percent is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 0.0008 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is carried out for one cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated, then Single Bond 2 adhesive is coated, and light curing is carried out to carry out prosthesis bonding.

EXAMPLE ninety two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

EXAMPLES ninety three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, surface drying is carried out, a Spectrum adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example ninety four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is kept wet, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example ninety-five

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, surface drying is carried out, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example ninety six

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution for 20s is coated on the surface, 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution for 20s is coated on the surface, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example ninety seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of zinc chloride aqueous solution with the mass fraction of 81.2% is coated on the surface for 20s, 20 mul of solution (B) with the mass fraction of 15.7% of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + the solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, a Spectrum adhesive is coated, and illumination curing is carried out to bond the restoration.

Example ninety eight

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is kept wet, Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis bonding.

Example ninety nine

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is a cycle, the cycle is repeated for 3 times, the surface is dried, Single Bond 2 adhesive is coated, and illumination curing is carried out to Bond the prosthesis.

Example one hundred

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution for 20s is coated on the surface, 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution for 20s is coated on the surface, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated on the surface, and then illumination curing is carried out to bond the prosthesis.

Example one hundred and one

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the restoration.

Example one hundred and two

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7% sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and light irradiation curing is carried out to bond the restoration.

Example one hundred and three

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2% zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7% sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15% 10-MDP ethanol solution is coated on the surface, a Spectrum adhesive is coated, and then illumination curing is carried out to bond the restoration.

Example one hundred and four

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent and the mass fraction of zinc chloride water solution for 20s is coated on the surface, 20 mul of solution (B) with the mass fraction of 15.7 percent and the mass fraction of sodium sulfide water solution for 20s is coated on the surface, water vapor washing is carried out, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent and 10-MDP ethanol solution is coated on the surface, and then Single Bond 2 adhesive is coated and cured by illumination, so that prosthesis bonding is carried out.

Example one hundred and fifty

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing and surface drying are carried out, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, then Single Bond 2 adhesive is coated, and illumination curing is carried out to carry out prosthesis adhesion.

Example one hundred and six

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is kept wet, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and then light curing is carried out to carry out prosthesis bonding.

Example one hundred and seven

After phosphoric acid etching treatment on the surface of the dentin, water vapor washing is carried out, 20 mul of solution (A) with the mass fraction of 81.2 percent of zinc chloride aqueous solution is coated on the surface for 20s, then 20 mul of solution (B) with the mass fraction of 15.7 percent of sodium sulfide aqueous solution is coated on the surface for 20s, water vapor washing is carried out, the coating solution (A) + solution (B) + washing is carried out for a cycle, the cycle is repeated for 3 times, the surface is dried, 20 mul of solution (C) with the mass fraction of 15 percent of 10-MDP ethanol solution is coated on the surface, a Single Bond 2 adhesive is coated, and light curing is carried out to carry out prosthesis bonding.

Claims (7)

1. The application of the dental adhesion pretreatment system based on copper and zinc ions in the preparation of the dental adhesion pretreatment agent is characterized in that the system comprises a unitary system, a binary system or a ternary system, wherein the unitary system is a solution (A), the binary system consists of the solution (A) and a solution (B), the ternary system consists of the solution (A), the solution (B) and a solution (C), the solution (A) is a soluble copper salt solution, a soluble zinc salt solution and a soluble copper/zinc mixed solution thereof, the solution (B) is a soluble solution which reacts with the solution (A) to generate insoluble precipitates, the solution (B) is a soluble carbonate, a soluble sulfide, a soluble selenide, a soluble telluride, a soluble phosphate, a soluble alkali solution and a mixed solution of the two or more solutions, and the solution (C) is an organic monomorphized solution which can be chemically chelated with the copper ions/zinc ions and precipitates thereof The solution of the compound, the organic monomer compound in the solution (C) is selected from 2-hydroxyethyl methacrylate, 10-methacryloyloxydecyl phosphate, di (methacryloyloxyethyl) hydrogen phosphate, dipentaerythritol pentaacrylate phosphate and 2-methacryloyloxyethyl phenyl hydrogen phosphate, the solvent for dissolving the organic monomer compound is water, ethanol, acetone or any mixed solvent of the above solvents, and the solution (A), the solution (B) and the solution (C) are packaged separately;

wherein the soluble copper salt solution of the solution (A) is a soluble copper salt solution with the mass fraction of 0.0001 percent to the saturated concentration, and copper fluoride aqueous solution, copper chloride aqueous solution, copper sulfate aqueous solution, copper nitrate aqueous solution and mixed solution of the 2 or more solutions are selected;

wherein the soluble zinc salt solution is 0.0001 percent by mass to saturated concentration, and zinc fluoride aqueous solution, zinc chloride aqueous solution, zinc sulfate aqueous solution, zinc nitrate aqueous solution and mixed solution of the 2 or more solutions are selected;

wherein the soluble copper/zinc mixed solution is a mixed solution of any one or more than one copper salt solution and any one or more than one zinc salt solution;

the monobasic system, the binary system or the ternary system is applied before coating the adhesive after the surface of a tooth body is clinically treated by acid, wherein when the monobasic system is applied for dental adhesion pretreatment, the solution (A) can be coated for multiple times, when the binary system is applied for dental adhesion pretreatment, the solution (A) is coated firstly, then the solution (B) is coated, and then the adhesive is coated for dental adhesion, wherein when the ternary system is applied for dental adhesion pretreatment, the solution (A) is coated firstly, then the solution (B) is coated, and after water vapor flushing, the solution (C) is coated, then the adhesive is coated for dental adhesion.

2. The use according to claim 1, wherein the soluble carbonate concentration is 0.0001% by mass to a saturation concentration, and an aqueous solution of lithium carbonate, sodium carbonate, potassium carbonate, ammonium carbonate, or a mixture of 2 or more thereof is selected.

3. The use according to claim 1, wherein the soluble sulfide has a concentration of 0.0001% by mass to a saturation concentration, and is selected from an aqueous solution of lithium sulfide, an aqueous solution of sodium sulfide, an aqueous solution of potassium sulfide, an aqueous solution of ammonium sulfide, an aqueous solution of selenium sulfide, an aqueous solution of tellurium sulfide, and a mixture of 2 or more thereof.

4. The use according to claim 1, wherein the soluble selenide concentration is 0.0001% by mass to saturation concentration, and the aqueous solution of lithium selenide, aqueous solution of sodium selenide, aqueous solution of potassium selenide, aqueous solution of sodium selenate, aqueous solution of sodium selenite, and mixed solution of the above 2 or more solutions are selected.

5. The use of claim 1, wherein the soluble telluride concentration is 0.0001 wt% to saturation concentration, and the soluble telluride is selected from lithium telluride aqueous solution, sodium telluride aqueous solution, potassium telluride aqueous solution, sodium tellurite aqueous solution, and mixture solution of the above 2 solutions.

6. The use according to claim 1, wherein the soluble phosphate is selected from the group consisting of lithium monohydrogen phosphate, sodium monohydrogen phosphate aqueous solution, potassium monohydrogen phosphate aqueous solution, sodium dihydrogen phosphate aqueous solution, potassium dihydrogen phosphate aqueous solution, lithium phosphate, potassium phosphate, sodium phosphate, ammonium phosphate, and mixtures of 2 or more thereof, at a concentration of 0.0001% by mass to the saturation concentration.

7. The use according to claim 1, wherein the concentration of the soluble alkali solution is 0.0001% by mass to a saturated concentration, and ammonia, sodium hydroxide, potassium hydroxide, calcium hydroxide, barium hydroxide, strontium hydroxide, and a mixture of 2 or more thereof are selected.

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