CN112315948A - Oral ulcer wound nursing agent and preparation method thereof - Google Patents
Oral ulcer wound nursing agent and preparation method thereof Download PDFInfo
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- CN112315948A CN112315948A CN202011209735.7A CN202011209735A CN112315948A CN 112315948 A CN112315948 A CN 112315948A CN 202011209735 A CN202011209735 A CN 202011209735A CN 112315948 A CN112315948 A CN 112315948A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to an oral ulcer wound surface care agent and a preparation method thereof. The oral ulcer wound nursing agent comprises main functional components, a thickening agent, a coloring agent and water. The wound surface care agent disclosed by the invention is simple to use and convenient to operate, and can be used for quickly and effectively cleaning the wound surface, reducing the irritation of the ulcer wound surface to the outside, relieving the pain of ulcer and promoting the healing of ulcer.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an oral ulcer wound surface care agent and a preparation method thereof.
Background
Oral ulcer, commonly known as "aphtha", is a common ulcerative injury disease occurring in oral mucosa, which is mostly seen on mucosa of the inner side of the lip, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate and other parts, and is a round or oval pain ulcer point. The oral ulcer has severe pain and obvious local burning pain during the attack, serious patients can influence diet and speaking, the daily life is greatly inconvenient, and the oral ulcer can be complicated with the general symptoms of halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, hypodynamia, dysphoria, fever, lymphadenectasis and the like. Canker sores develop as a result of a combination of factors including topical trauma, stress, food, medication, malnutrition, altered hormone levels, and vitamin or trace element deficiencies. Systemic diseases, heredity, immunity and microorganisms may play an important role in the development and development of oral ulcers. Canker sores can be divided into three types, including recurrent canker sores, traumatic canker sores, canker sores with concomitant disease.
At present, the main treatment method of oral ulcer in China is local medication, and traditional Chinese medicine component medicines or glucocorticoid medicines with the functions of resisting inflammation, easing pain and promoting ulcer healing are locally used. In addition, patients with oral ulcer can also be supplemented with vitamin C to help eliminate oral inflammation and heal ulcer. However, the above methods all have certain limitations, mainly manifested in that the medicine needs to be applied repeatedly for many times every day, the operation is complex or frequent, and the local burning pain of the dental ulcer is still accompanied to a certain extent in the using process, which affects diet and speaking and causes great inconvenience to daily life.
Disclosure of Invention
The invention aims to provide an oral ulcer wound surface care agent.
The invention also aims to provide a preparation method of the oral ulcer wound care agent.
The oral ulcer wound care agent comprises 60-90 wt% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 1-10 wt% of thickening agent and the balance of water.
The wound surface care agent takes benzenesulfonic acid and benzenesulfonic acid derivatives as key functional components, rapidly extracts water in the oral ulcer part through the rapid water absorption effect of the key functional components, rapidly removes necrotic tissues in the oral ulcer part through the corrosion effect of the key functional components, and forms a layer of white protective film with a physical barrier effect on the ulcer surface. Therefore, the wound nursing agent provided by the invention is used for nursing the ulcer wound by utilizing non-pharmacological action.
The prior art does not use the key functional components as auxiliary raw materials of pharmacologic action. The key functional components exert effects by utilizing a physical barrier formed by the corrosive action of the key functional components on the ulcer wound surface, and therefore, are different from pharmacological products with the same expected action in the prior art. The wound surface care agent disclosed by the invention is simple to use and convenient to operate, and can be used for quickly and effectively cleaning the wound surface, reducing the irritation of the ulcer wound surface to the outside, relieving the pain of ulcer and promoting the ulcer healing.
According to the oral ulcer wound nursing agent of the embodiment of the invention, the benzene sulfonic acid derivative comprises p-hydroxybenzene sulfonic acid, hydroxyl methoxy benzene sulfonic acid, methane sulfonic acid, benzene sulfonic acid, methyl sulfonic acid and/or p-toluene sulfonic acid.
According to the specific embodiment of the invention, the care agent for the wound surface of the oral ulcer further comprises 0.01-1% of a coloring agent.
According to the specific embodiment of the invention, the oral ulcer wound nursing agent comprises 65-85 wt% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 5-9 wt% of thickening agent, 0.02-0.5 wt% of colorant and the balance of water.
The oral ulcer wound surface care agent is characterized by comprising 70-80 wt% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 2-3 wt% of thickening agent, 0.01-0.05 wt% of coloring agent and the balance of water. When the concentration of the thickening agent is 2-3%, the dosage form of the wound care agent can be correspondingly adjusted to be ointment
According to the specific embodiment of the invention, the oral ulcer wound nursing agent comprises 75-80 wt% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 6-7 wt% of thickening agent, 0.03-0.05 wt% of colorant and the balance of water.
According to the oral ulcer wound surface care agent of the embodiment of the invention, the thickening agent is silicon dioxide, and the specific surface area of the silicon dioxide is not less than 100m2(ii) in terms of/g. The silicon dioxide can not only adjust the viscosity of the medicament, but also stably exist in the medicament without denaturation.
According to the oral ulcer wound surface care agent of the embodiment of the invention, the coloring agent is amaranth, carmine, erythrosine and/or allura red.
The preparation method of the oral ulcer wound care agent according to the embodiment of the invention comprises the following steps: weighing the thickening agent and the benzenesulfonic acid and/or benzenesulfonic acid derivatives in sequence, adding water, stirring for 10-15min, adding water to a ratio while stirring, and stirring for 30-60 min.
According to the preparation method of the oral ulcer wound care agent provided by the embodiment of the invention, the thickening agent, the benzenesulfonic acid and/or benzenesulfonic acid derivative are stirred for 10-15min, then the coloring agent is added, and water is added to the mixture ratio while stirring.
The invention can ensure that the dosage form is liquid preparation and semisolid preparation by properly adjusting the dosage of the thickening agent on the basis of ensuring the content of key functional components, for example, the dosage of the thickening agent is 6-7 percent when preparing an ointment dosage form; and the amount of thickener in the liquid dosage form is 2-3%.
When the oral ulcer wound care agent is prepared into a semi-solid preparation, PP material thermoforming, filling and aluminum-plastic heat sealing packaging can be adopted, and a cotton swab is matched to facilitate direct tearing of an aluminum-plastic film and dipping of the cotton swab in the semi-solid preparation for use; the oral ulcer wound care agent can also be filled in a PP plastic bottle and matched with a reusable smearing rod, so that the semisolid preparation can be conveniently and directly taken for use.
When the oral ulcer wound care agent is prepared into a liquid preparation, the liquid preparation can be directly filled into a plastic tube with a cotton swab head, one end of the cotton swab is broken off to enable the other end of the cotton swab to be soaked by the liquid preparation, and then the liquid preparation is smeared on an affected part for use.
When in use, the wound surface care agent can be directly smeared on the surface of ulcer, the coating time is not more than 20 seconds, and then the wound surface care agent can be used for thorough gargling. Generally, a single application provides relief from oral pain and discomfort, and more than two treatments on the same site are not recommended and do not require excessive use.
The invention has the beneficial effects that:
the wound surface care agent disclosed by the invention is simple to use and convenient to operate, and can be used for quickly and effectively cleaning the wound surface, reducing the irritation of the ulcer wound surface to the outside, relieving the pain of ulcer and promoting the healing of ulcer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
1.1 the oral ulcer wound nursing agent comprises 60 percent of benzenesulfonic acid, 2 percent of thickening agent (silicon dioxide), 0.03 percent of coloring agent (amaranth) and the balance of water according to weight percentage.
The preparation method of the wound care agent comprises the following steps: weighing the thickening agent, then weighing and adding the key functional components, firstly stirring for 10min, then weighing and adding the coloring agent, adding the purified water while stirring until the mixture ratio is balanced, and then stirring for 30 min.
1.2 the oral ulcer wound surface care agent comprises 75% of p-hydroxybenzene sulfonic acid, 7% of thickening agent (silicon dioxide), 0.5% of coloring agent (carmine) and the balance of water according to weight percentage.
The preparation method of the wound care agent comprises the following steps: weighing the thickening agent, then weighing and adding the key functional components, firstly stirring for 12min, then weighing and adding the coloring agent, adding the purified water while stirring until the mixture ratio is balanced, and then stirring for 40 min.
1.3 the oral ulcer wound surface nursing agent comprises 90 percent of p-toluenesulfonic acid, 3 percent of thickening agent (silicon dioxide), 1 percent of colorant (allure red) and the balance of water according to weight percentage.
The preparation method of the wound care agent comprises the following steps: weighing the thickening agent, then weighing and adding the key functional components, firstly stirring for 15min, then weighing and adding the coloring agent, adding the purified water while stirring until the mixture ratio is balanced, and then stirring for 60 min.
Example 2 verification of the effectiveness of the use of wound care Agents of the invention
Case one:
the patients: zhangqi, woman, age 32
The main complaints are: oral ulcer for 3 days;
checking: one large ulcer of mung bean in the oral cavity;
and (3) diagnosis: recurrent oral ulceration;
treatment: the ointment is applied to the affected part of the ulcer surface, and is used 7 am earlier and 40min earlier on the day;
the effect is as follows: after gargling for 5-10 seconds, the pain of the dental ulcer is quickly relieved.
Case two:
the patients: liu Zhi, female age 35 years old
The main complaints are: dental ulcer for 2 days;
checking: patients carelessly bite the junction of the lower lip mucosa when eating food for the previous days, and the patients suffer from mouth ulcer pain and intermittent bleeding;
and (3) diagnosis: traumatic ulcers;
treatment: the medicine is uniformly applied, and the patient is prescribed to gargle after five seconds;
the effect is as follows: the pain and numbness completely disappear after the liniment is applied.
Case three:
the patients: lichi, male, sales staff of a company, age 26
The main complaints are: the continuous speaking involves the damaged part of the oral mucosa, and influences the daily work;
checking: the people prefer spicy diet in the near day, and three ulcer surfaces appear at the oral mucosa;
and (3) diagnosis: oral ulcers resulting from prolonged stomach fire;
treatment: applying on two oral ulcer surfaces;
the effect is as follows: after the paste is applied, the pain of the oral ulcer disappears, and the influence of the oral ulcer on daily work is effectively avoided; covering with a white protective film, and avoiding oil and pungency during the period, and healing oral ulcer within 3 days.
Case four:
the patients: wangzhi, female, age 18 years old
The main complaints are: oral ulcer in menstrual period affects diet, and pain is caused when the wound surface is touched by eating;
checking: the content of progesterone in menstrual period is low, and oral ulcer is easily caused;
and (3) diagnosis: oral ulcer in menstrual period;
treatment: during the use process, patients have slight stabbing pain;
the effect is as follows: pain disappears after five seconds of mouth washing, and the influence of oral ulcer on daily diet is effectively avoided.
Case five:
the patients: xuezhi, female, wearing tooth socket, 23 years old
The main complaints are: dental ulcer for 2 days;
checking: the orthodontic brackets cause irritation to the mucosa, thereby causing oral ulcers;
and (3) diagnosis: traumatic oral ulcer;
treatment: smearing, and gargling for 5-10 seconds;
the effect is as follows: the pain of the oral ulcer can be rapidly solved within 5-10 seconds; the white protective film falls off within 4 days, the ulcer surface of the oral cavity is healed, and no pain is caused.
Case six:
the patients: li in, Man, 45 years old
The main complaints are: canker sores affect diet;
checking: oral ulcers resulting from gingivitis;
and (3) diagnosis: oral ulcers with concomitant disease;
treatment: smearing, and gargling for 5-10 seconds;
the effect is as follows: effectively reduces the external stimulation on the ulcer surface and accelerates the healing of the oral ulcer surface.
Case seven:
the patients: chengzhi, male, age 27
The main complaints are: canker sores affect diet;
checking: oral ulcers resulting from gingivitis;
and (3) diagnosis: oral ulcers with concomitant disease;
treatment: smearing, and gargling for 5-10 seconds;
the effect is as follows: under the normal diet condition, the white film falls off for about 72 hours, and the ulcer surface of the oral cavity is healed.
Case eight:
the patients: li in some, man often eat betel nut, 32 years old
The main complaints are: canker sores affect diet;
checking: canker sore caused by frequent chewing of betel nut;
and (3) diagnosis: traumatic oral ulcer;
treatment: smearing, and gargling for 5-0 seconds;
the effect is as follows: after gargling for 5-10 seconds, the pain at the oral ulcer part disappears. The white protective film falls off about 72 hours, the ulcer surface of the oral cavity is healed, pain is not felt, and normal diet is effectively avoided being influenced.
Case nine:
the patients: liu Yi, ren, age 16
The main complaints are: dental ulcer for 2 days;
checking: two oral ulcer surfaces appear at the oral mucosa;
and (3) diagnosis: food preference, oral ulcer due to vitamin B2 deficiency;
treatment: smearing, and gargling for 5-10 seconds.
The effect is as follows: when the Chinese medicinal composition is applied to an ulcer surface, pain is caused, but after the Chinese medicinal composition is rinsed for 5-10 seconds, the pain caused by ulcer is eliminated, and a layer of white protective film is formed. After the oral ulcer liquid is used, vitamin B2 is supplemented, and the white protective film falls off after about 72 hours, so that the oral ulcer is healed.
Case ten:
the patients: jiangzhi, male, age 28
The main complaints are: when eating the fishbone, the mucosa of the oral ulcer is scratched carelessly to form the oral ulcer;
checking: an oral ulcer surface with the size of a nail cover appears at the position of the oral mucosa;
and (3) diagnosis: traumatic oral ulcer;
treatment: smearing, and gargling for 5-10 seconds;
the effect is as follows: the pain of the ulcer surface disappears after gargling for 5-10 seconds, and the healing time of the oral ulcer is 4 days.
Case eleven:
the patients: xie Zhi, woman, age 24
The main complaints are: the oral ulcer is obvious in pain after 2 days, and daily life is influenced;
checking: three round ulcer points on the oral mucosa;
and (3) diagnosis: recurrent oral ulceration;
treatment: smearing, and gargling for 5-10 seconds;
the effect is as follows: the pain of the gargle ulcer surface disappears after 5-10 seconds of gargling, and the influence of the dental ulcer on daily life is effectively avoided.
Case twelve:
the patients: zhou Zhi, woman 45 years old
The main complaints are: oral ulcer for 3 days;
checking: two ulcers with large mung beans appear in the oral ulcer;
and (3) diagnosis: oral ulcer caused by high mental stress, staying up all night and low immunity;
treatment: smearing, gargling for 5-10 seconds, simple use and convenient operation;
the effect is as follows: the gargle can rapidly relieve pain after 5 to 10 seconds. A layer of white protective film is formed immediately, the ulcer wound surface is effectively reduced from external stimulation, the ulcer healing is promoted, and the oral ulcer healing time is 4 days.
Case thirteen:
the patients: Huang-Shi, male, 27 years old
The main complaints are: dental ulcer for 2 days;
checking: an elliptic ulcer appears in the oral ulcer;
and (3) diagnosis: recurrent oral ulceration;
treatment: cleaning water on the oral ulcer surface by using a cotton swab, smearing the water on the oral ulcer surface, and gargling for 5-10 seconds;
the effect is as follows: the gargle can rapidly relieve pain after 5 to 10 seconds. A layer of white protective film is formed immediately, and the healing time of the oral ulcer is 3 days.
114 patients with oral ulcer are collected, the oral ulcer wound care agent is adopted for nursing, a summary table of using effect tests and evaluation is provided, and the results are shown in table 1:
TABLE 1 summary of the usage of the stomatocace wound nursing agent
As can be seen from Table 1, the wound care agent of the invention can take effect quickly after being applied to the ulcer wound, and is uncomfortable only in the application process, the healing time of the oral ulcer is 3.6 days, and the oral ulcer can be cured quickly and is generally accepted by patients.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The oral ulcer wound care agent is characterized by comprising 60-90 wt% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 1-10 wt% of thickening agent and the balance of water.
2. The stomatocace wound care agent according to claim 1, wherein the benzenesulfonic acid derivative comprises p-hydroxybenzenesulfonic acid, hydroxymethoxybenzenesulfonic acid, methanesulfonic acid, benzenesulfonic acid, methanesulfonic acid and/or p-toluenesulfonic acid.
3. The oral ulcer wound care agent according to claim 1 or 2, wherein the wound care agent further comprises 0.01-1% of a coloring agent.
4. The oral ulcer wound surface care agent according to claim 1 or 2, characterized by comprising 65-85% of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 5-9% of thickening agent, 0.02-0.5% of coloring agent and the balance of water by weight.
5. The oral ulcer wound surface care agent according to claim 1 or 2, characterized by comprising 70-80% by weight of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 2-3% by weight of thickening agent, 0.01-0.1% by weight of coloring agent and the balance of water.
6. The oral ulcer wound surface care agent according to claim 1 or 2, which comprises 75-80% by weight of benzenesulfonic acid and/or benzenesulfonic acid derivatives, 6-7% by weight of thickening agent, 0.03-0.05% by weight of coloring agent and the balance of water.
7. The oral ulcer wound surface care agent according to claim 1 or 2, wherein the thickener is silica, and the specific surface area of the silica is not less than 100m2/g。
8. The wound care agent for oral ulcers according to claim 3, characterized in that said coloring agent is amaranth, carmine, erythrosine and/or allura red.
9. The process for producing an oral ulcer wound care agent according to claim 1, which comprises the steps of: weighing the thickening agent and the benzenesulfonic acid and/or benzenesulfonic acid derivatives in sequence, adding water, stirring for 10-15min, adding water to a ratio while stirring, and stirring for 30-60 min.
10. The method for preparing a wound care preparation for oral ulcer according to claim 9, wherein the thickener, benzenesulfonic acid and/or benzenesulfonic acid derivative are stirred for 10 to 15min, and then the colorant is added, and water is added to the mixture while stirring.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011209735.7A CN112315948A (en) | 2020-11-03 | 2020-11-03 | Oral ulcer wound nursing agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011209735.7A CN112315948A (en) | 2020-11-03 | 2020-11-03 | Oral ulcer wound nursing agent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113633628A (en) * | 2021-07-08 | 2021-11-12 | 方红英 | Liquid wound dressing for nursing superficial small wounds of oral cavity and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1967209B1 (en) * | 1968-05-09 | 1979-05-23 | Egyt Gyogyszervegyeszeti Gyar, Budapest | Orally or parenterally administrable medicinal products with anti-ulcer effects |
| ZA827839B (en) * | 1981-10-28 | 1983-08-31 | Nippon Zoki Pharmaceutical Co | Nove peptide compounds,a process for manufacturing them,pharmaceutical compositions containing them and methods for treating ulcer and thrombus with them |
| US5891890A (en) * | 1997-04-04 | 1999-04-06 | Shiseido Co., Ltd. | Benzamide derivatives, anti-ulcer drug, and antibacterial drug |
| CN111700887A (en) * | 2020-07-14 | 2020-09-25 | 尚缔健康国际有限公司 | Benzenesulfonic acid preparation for treating mucosal rupture |
-
2020
- 2020-11-03 CN CN202011209735.7A patent/CN112315948A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1967209B1 (en) * | 1968-05-09 | 1979-05-23 | Egyt Gyogyszervegyeszeti Gyar, Budapest | Orally or parenterally administrable medicinal products with anti-ulcer effects |
| ZA827839B (en) * | 1981-10-28 | 1983-08-31 | Nippon Zoki Pharmaceutical Co | Nove peptide compounds,a process for manufacturing them,pharmaceutical compositions containing them and methods for treating ulcer and thrombus with them |
| US5891890A (en) * | 1997-04-04 | 1999-04-06 | Shiseido Co., Ltd. | Benzamide derivatives, anti-ulcer drug, and antibacterial drug |
| CN111700887A (en) * | 2020-07-14 | 2020-09-25 | 尚缔健康国际有限公司 | Benzenesulfonic acid preparation for treating mucosal rupture |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113633628A (en) * | 2021-07-08 | 2021-11-12 | 方红英 | Liquid wound dressing for nursing superficial small wounds of oral cavity and preparation method thereof |
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Application publication date: 20210205 |