CN112305087B - Gas chromatography-ion mobility spectrometer combined system - Google Patents
Gas chromatography-ion mobility spectrometer combined system Download PDFInfo
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- CN112305087B CN112305087B CN201910670723.5A CN201910670723A CN112305087B CN 112305087 B CN112305087 B CN 112305087B CN 201910670723 A CN201910670723 A CN 201910670723A CN 112305087 B CN112305087 B CN 112305087B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention provides a gas chromatography-ion mobility spectrometer combined system, which comprises: a gas chromatography device for pre-separating a sample carrier gas to form a pre-separated sample carrier gas; an ion mobility spectrometer device in fluid communication with the gas chromatography device for detecting the pre-separated sample carrier gas; and the circulating gas path assembly is used for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after the migration gas is processed. The circulating gas path assembly includes an airflow buffering four-way component configured to distribute the migration gas flowing into the ion mobility spectrometer and the carrier gas flowing into the ion mobility spectrometer device to achieve a desired ratio.
Description
Technical Field
The invention relates to the technical field of analysis and detection, in particular to a gas chromatography-ion mobility spectrometer combined system.
Background
An Ion Mobility Spectrometer (IMS) has the characteristics of simple structure, high sensitivity, high analysis speed and the like, and is widely used for detection or monitoring of chemical warfare agents, drugs, explosives, environment and the like.
The gas chromatography-ion mobility spectrometry (GC-IMS) combined technology not only effectively utilizes the outstanding separation capability of the gas chromatography to a complex sample, but also effectively utilizes the characteristics of high sensitivity of an IMS detector and wide material selectivity of a positive mode and a negative mode, thereby greatly improving the detection precision and the detection sensitivity of a mixture.
However, in the gas path systems of the above two instruments, the flow regulating valves and the buffer chambers are adopted to regulate and control the migration gas flow of the positive-mode ion migration tube and the negative-mode ion migration tube to be equal, and in this way, the flow is controlled to be equal by the regulating valves and the buffer chambers, on one hand, when the sample carrier gas flows through the flow regulating valves, the sample carrier gas is remained in the valves and is difficult to clean, and on the other hand, the number of the flow regulating valves increases the space volume, the weight and the cost of the instrument to a certain extent. Moreover, the purpose that the flow rates of the migration gas and the sample carrier gas of the positive and negative mode ion migration tubes are equal is realized in a gas path system of the gas chromatography-ion mobility spectrometry combined device in a continuous supplement mode of high-purity nitrogen, and the high-purity nitrogen serving as the GC carrier gas can influence the ionization environment of the IMS to cause the change of the positive mode reaction ion components when continuously entering the IMS, thereby influencing the stability of a spectrogram.
Disclosure of Invention
Therefore, in order to at least partially avoid the problems of large volume, easy residue and high cost caused by controlling the flow of the migration gas of the positive and negative mode ion migration tubes to be equal through the flow regulating valve and the buffer cavity, the embodiment of the invention provides a gas chromatography-ion mobility spectrometer combined system.
According to an aspect of the present invention, there is provided a combined gas chromatography and ion mobility spectrometer system comprising:
a gas chromatography device for pre-separating a sample carrier gas to form a pre-separated sample carrier gas;
an ion mobility spectrometer device in fluid communication with the gas chromatography device for detecting the pre-separated sample carrier gas; and
a circulating gas path component for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after processing the migration gas,
the circulating gas path assembly comprises an airflow buffering four-way component, and the airflow buffering four-way component is configured to distribute migration gas flowing into the ion mobility spectrometer and circulating carrier gas flowing into the ion mobility spectrometer device.
In some embodiments, the flow buffering four-way component includes a first buffer chamber, an inlet pipe in communication with the first buffer chamber, and a first outlet pipe, a second outlet pipe, and a third outlet pipe in communication with the first buffer chamber.
In some embodiments, the inlet pipe, the first outlet pipe, the second outlet pipe and the third outlet pipe are distributed in the same plane around the first buffer chamber at equal intervals, the first outlet pipe and the second outlet pipe are arranged on a first straight line, and the inlet pipe and the third outlet pipe are arranged on a second straight line perpendicular to the first straight line.
In some embodiments, the diameters of the first outlet pipe and the second outlet pipe are equal and are both larger than the diameter of the third outlet pipe, and the inlet pipe, the first outlet pipe, the second outlet pipe and the third outlet pipe are provided with inverted conical structures and connecting threads.
In some embodiments, the ion mobility spectrometer comprises a positive ion mobility tube and a negative ion mobility tube,
the circulating gas path assembly also comprises a buffer cavity, a first branch, a second branch, a third branch, a fourth branch, a fifth branch and a sixth branch, wherein the first branch, the second branch and the third branch are connected with each other, and the fourth branch, the fifth branch and the sixth branch are communicated with the gas flow buffer four-way component;
wherein the migration gas discharged from the positive ion transport tube and the negative ion transport tube, respectively, first flows into a buffer chamber, after which the migration gas is guided out of the buffer chamber through a first branch and then branched by a three-way valve, a part of the migration gas is sent into the first buffer chamber through the inlet pipe through a second branch, and the remaining migration gas is discharged out of the combined system through a third branch,
and a part of the migration gas in the first buffer chamber flows out through the first outlet pipe and the second outlet pipe respectively and is conveyed to the positive ion migration pipe and the negative ion migration pipe through the fifth branch and the sixth branch, and the other part of the migration gas in the first buffer chamber is conveyed to the positive ion migration pipe and the negative ion migration pipe through the third outlet pipe and the fourth branch.
In some embodiments, a diaphragm pump is disposed on the first branch for pumping the migration gas into the first branch;
a molecular sieve is arranged on the second branch;
a purifier and a microporous filter membrane are arranged on the third branch;
and a flow regulating valve is arranged on the fourth branch.
In some embodiments, the resistance of the third outlet tube is adjusted so that the circulating carrier gas entering the positive ion transport tube and the negative ion transport tube is distributed in a desired ratio to the transport gas.
In some embodiments, the gas chromatography-ion mobility spectrometer combined system further comprises a connecting disc gas circuit main body, wherein the connecting disc gas circuit main body comprises a second buffer chamber, a first inlet, a first outlet, a second inlet and a second outlet which are respectively communicated with the second buffer chamber,
a part of the sample carrier gas discharged from the gas chromatography apparatus enters the second buffer chamber through the first inlet, and enters the positive ion transfer tube and the negative ion transfer tube through the first outlet and the second outlet, respectively, and the remaining part of the sample carrier gas discharged from the gas chromatography apparatus is discharged out of the combined system.
In some embodiments, the first inlet, the first outlet, the second inlet and the second outlet are distributed in the same plane at equal intervals around the second buffer chamber of the land air passage body,
the first and second outlets are arranged on a third line and the first and second inlets are arranged on a fourth line perpendicular to the third line.
In some embodiments, the first outlet and the second outlet have the same diameter, and the first inlet, the first outlet pipe, the second inlet, and the second outlet are provided with inverted conical structures and connecting threads.
In some embodiments, the remainder of the sample carrier gas exiting the gas chromatography device is purged through a purifier before exiting the combined system;
the sample carrier gas is introduced into the gas chromatography apparatus through an inlet of the gas chromatography apparatus through a line provided with a purifier, a combination valve and a regulating valve.
According to another aspect of the present invention, there is provided a circulating gas path assembly for an ion mobility spectrometer or a combined gas chromatography-ion mobility spectrometer system, wherein,
the circulating gas path component is used for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after processing the migration gas,
wherein the circulating gas path assembly includes an airflow buffering four-way component configured to distribute a migration gas flowing into the ion mobility spectrometer and a carrier gas flowing into the ion mobility spectrometer device.
In one embodiment, the four-way airflow buffering component comprises a first buffering chamber, an inlet pipe communicated with the first buffering chamber, and a first outlet pipe, a second outlet pipe and a third outlet pipe communicated with the first buffering chamber, wherein the diameters of the first outlet pipe and the second outlet pipe are equal.
According to yet another aspect of the present invention, there is provided a connected disk gas path body for an ion mobility spectrometer or a combined gas chromatography-ion mobility spectrometer system, wherein,
the connecting disc gas circuit main body is arranged between a positive ion migration tube and a negative ion migration tube of the ion mobility spectrometer,
the connecting disc gas circuit main body comprises a second buffer chamber, a first inlet, a first outlet, a second inlet and a second outlet which are respectively communicated with the second buffer chamber,
and the sample carrier gas enters the second buffer chamber through the first inlet and enters the positive ion migration tube and the negative ion migration tube through the first outlet and the second outlet respectively, and the second inlet is connected with a circulating gas circuit component of the ion mobility spectrometer.
The first and second outlets are of equal diameter.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings used in the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without any inventive work.
FIG. 1 is a schematic diagram of the structure and gas path principle of a gas chromatography-ion mobility spectrometer combined system according to an embodiment of the invention;
FIG. 2 shows a schematic view of the airflow buffering four-way component shown in FIG. 1;
fig. 3 shows a structural schematic view of the land air passage body shown in fig. 1.
Detailed Description
While the disclosure is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It should be understood, however, that the drawings and detailed description thereto are not intended to limit the disclosure to the particular form disclosed, but on the contrary, the intention is to cover all modifications, equivalents and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims. The figures are for illustration and are not drawn to scale.
The use of the terms first, second, etc. in this description is not intended to distinguish between different components, but rather to rank or indicate importance or primary-secondary relationship.
According to the present general inventive concept, there is provided a gas chromatography-ion mobility spectrometer combined system, including:
a gas chromatography device for pre-separating a sample carrier gas to form a pre-separated sample carrier gas;
an ion mobility spectrometer device in fluid communication with the gas chromatography device for detecting the pre-separated sample carrier gas; and
a circulating gas path component for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after processing the migration gas,
the circulating gas path assembly comprises a gas flow buffering four-way component, and the gas flow buffering four-way component is configured to distribute the migration gas flowing out of the ion mobility spectrometer and the sample carrier gas flowing into the ion mobility spectrometer device again to realize equal flow of the migration gas and the sample carrier gas in the ion mobility spectrometer.
By using the air flow buffering four-way component in the circulating air path component, the gas chromatography-ion mobility spectrometer combined system can avoid the defects of large volume, easy residue, high cost and the like of the combined system caused by controlling the equal flow of the migration gas in the positive and negative ion migration tubes in the ion mobility spectrometer device through the flow regulating valve and the buffer cavity. In addition, the flow in the circulating air path assembly can be free of adjustment by using the airflow buffering four-way component. In conclusion, the air flow buffering four-way component not only can use the adjusting valves as few as possible, but also can reduce the manufacturing cost, save the space and lighten the weight, so that the combined system is light and compact in structure.
Specifically, as shown in FIG. 1, the combined gas chromatography and ion mobility spectrometer system 100 includes a gas chromatography device 10, an ion mobility spectrometer device 20, and an associated circulating gas path assembly 30.
The gas chromatography device 10 is used for pre-analyzing a sample carrier gas to form a pre-separated sample carrier gas; and the ion mobility spectrometer device 20 is in fluid communication with the gas chromatography device 10 for detecting the pre-separated sample carrier gas.
In one example, the gas chromatography apparatus 10 can include a chromatography column and a heating jacket that is sleeved outside the chromatography column. The chromatographic column can be, for example, a concentrated capillary column with high column efficiency and strong separation capacity. Of course, the gas chromatography apparatus 10 may also employ alternative apparatus known in the art or that may be adapted for use.
As shown in fig. 1, a sample carrier gas is introduced into the gas chromatography apparatus 10 from a gas source 115 via an inlet of the gas chromatography apparatus 10 through a line provided with a purifier 116A, a combination valve 117, and a flow regulating valve 118A.
In one example, the ion mobility spectrometer device 20 may include a positive ion mobility tube 21 and a negative ion mobility tube 22, such as an integrated ceramic dual mode mobility tube, or a positive and negative single mode mobility tube.
In one example, the circulating gas path assembly 30 is configured to receive a migration gas exhausted from the ion mobility spectrometer device 20 and to circulate the migration gas into the ion mobility spectrometer device 20 after processing the migration gas. The circulating gas path assembly 30 includes a gas flow buffer four-way component 40, the gas flow buffer four-way component 40 configured to distribute the migration gas flowing into the ion mobility spectrometer 20 and the circulating carrier gas flowing into the ion mobility spectrometer device 20. The circulating carrier gas comes from the gas flow buffering four-way component 40 in the circulating gas path assembly 30, and the circulating carrier gas can be zero gas or other gases suitable for being used as carrier gas.
As shown in fig. 1, the air circulation path assembly 30 further includes a buffer chamber 31, a first branch S1, a second branch S2, a third branch S3 connected to each other, and a fourth branch S4, a fifth branch S5 and a sixth branch S6 communicated with the air flow buffering four-way component 40. Here, the buffer chamber 31 is used to reduce disturbance of the pulsed airflow inside the ion mobility spectrometer due to the pumping of the diaphragm pump 121, thereby improving the stability of the signal of the ion mobility spectrometer.
Specifically, as shown in connection with fig. 2, the four-way airflow buffering member 40 includes a first buffer chamber 46, an inlet pipe 41 communicating with the first buffer chamber 46, and a first outlet pipe 42, a second outlet pipe 43, and a third outlet pipe 44 communicating with the first buffer chamber 46.
The first buffer chamber 46 or the flow buffering four-way component 40 is hollow. The inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43 and the third outlet pipe 44 are in communication with or pass through the first buffer chamber 46.
In another example, the inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43 and the third outlet pipe 44 are equally spaced apart around the first buffer chamber 46 and distributed in the same plane, the first outlet pipe 42 and the second outlet pipe 43 are arranged on a first straight line L1, and the inlet pipe 41 and the third outlet pipe 44 are arranged on a second straight line L2 perpendicular to the first straight line L1.
Further, the central axes passing through the inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43, and the third outlet pipe 44 intersect at a central point of the plane, i.e., intersect at the central point.
In the illustrated example, the first outlet tube 42 and the second outlet tube 43 are of equal diameter, so that the flow of the transport gas into the positive ion transport tube can be made equal to the flow of the transport gas into the negative ion transport tube. The diameters of the first outlet pipe 42 and the second outlet pipe 43 may be larger than the diameter of the third outlet pipe 44, and the inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43, and the third outlet pipe 44 are provided with inverted conical structures and connecting threads to facilitate connection with the air passage connecting pipe.
In addition, in order to prevent the leakage of the air flow from the joints, O-rings may be further installed at the fitting surfaces of the inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43, and the third outlet pipe 44 and the first buffer chamber 46, respectively, to achieve sealing.
It should be noted that the four-way airflow buffering member 40 can be a single piece or an assembly, i.e., the first buffering chamber 46 and the inlet pipe 41, the first outlet pipe 42, the second outlet pipe 43 and the third outlet pipe 44 are assembled after being manufactured separately.
A diaphragm pump 121 is arranged on the first branch S1 and is used for pumping the migration gas into the first branch S1;
the second branch S2 is provided with a molecular sieve 124 for purifying the migration gas for circulation;
the third branch S3 is provided with a purifier 116B and a microporous membrane 123 for purifying the migration gas before discharging the migration gas to the outside of the combined system 100.
A flow regulating valve 118B is disposed on the fourth branch S4. In this way, the magnitude of the resistance of the third outlet pipe 44 can be regulated by the flow regulating valve 118B, so that the flow rates of the circulating carrier gas and the migration gas entering the positive ion transport pipe 21 and the negative ion transport pipe 22 are distributed as desired. For example, the original flow rate entering the first buffer chamber 46 through the inlet pipe 41 is 800mL/min, the flow rates of the transport gas exiting the first outlet pipe 42 and the second outlet pipe 43 are both 300mL/min, and the flow rate of the circulating carrier gas exiting the third outlet pipe 44 is 200 mL/min. If the flow rate of the carrier gas is too large and is desired to be reduced, the flow rate can be reduced by adjusting the flow rate adjusting valve 118B, for example, the flow rate of the circulating carrier gas exiting from the third outlet pipe 44 is adjusted to 300mL/min, and the flow rates of the two paths of carrier gases can be reduced to 250mL/min, so that the desired distribution ratio of the circulating carrier gas and the two paths of carrier gases is achieved, and finally, the reasonable distribution ratio of the sample carrier gas and the two paths of carrier gases is also achieved.
The first branch S1 is branched into a second branch S2 and a third branch S3 by a three-way valve 122.
In an example, the combined gas chromatography and ion mobility spectrometer system 100 further comprises a connecting disc gas circuit body 50, wherein the connecting disc gas circuit body 50 comprises a second buffer chamber 56, a first inlet 51, a first outlet 52, a second inlet 54 and a second outlet 53 which are respectively communicated with the second buffer chamber 56.
It should be noted that the land air passage body 50 may be a unitary piece or assembly.
A part of the sample carrier gas discharged from the gas chromatography device 10 enters the second buffer chamber 56 via the first inlet 51, and enters the positive ion transport tube 21 and the negative ion transport tube 22 via the first outlet 52 and the second outlet 53, respectively. In addition, the remaining portion of the sample carrier gas exiting the gas chromatography device 10 exits the combined system 100.
As shown in fig. 3, the first inlet 51, the first outlet 52, the second inlet 54 and the second outlet 53 are equally spaced in the same plane around the second buffer chamber 56 of the land air passage body 50,
the first outlet 52 and the second outlet 53 are arranged on a third straight line L3, and the first inlet 51 and the second inlet 54 are arranged on a fourth straight line L4 perpendicular to the third straight line L3.
The land air passage body 50 or the second buffer chamber 56 is hollow. The first inlet 51, the first outlet 52, the second inlet 54 and the second outlet 53 are in communication with the second buffer chamber 56.
Further, the central axes passing through the first and second inlets 51 and 54 and the central axes passing through the first and second outlets 52 and 53 intersect each other at a central point of the plane, i.e., intersect at the central point.
The first inlet 51, the first outlet 52, the second inlet 54 and the second outlet 53 are all provided with an inverted conical structure and connecting threads so as to be connected with the gas path connecting pipe.
In addition, in order to prevent the leakage of the air flow from the joint, O-rings may be further installed at the assembling surfaces of the first inlet 51, the first outlet 52, the second inlet 54 and the second outlet 53 and the second buffer chamber 56, respectively, to achieve sealing.
In addition, the diameters of the first outlet 52 and the second outlet 53 are preferably equal, so that it is possible to achieve an equal flow of carrier gas into the positive ion transfer tube and an equal flow of carrier gas into the negative ion transfer tube.
As shown in fig. 1, the gas chromatography-ion mobility spectrometer combined system 100 further includes a buffer bottom plate 120, and the circulating gas path assembly 30, the gas chromatography device 10, and the ion mobility spectrometer 20 are disposed on the buffer bottom plate 120, so that not only can the influence of the pulse gas flow and the instrument vibration on the gas flow inside the positive and negative ion mobility tubes 21 and 22 when the diaphragm pump 121 works be effectively reduced, but also the installation, debugging, and maintenance are facilitated, which will not be described again.
It is understood that the gas chromatography-ion mobility spectrometer combined system 100 may further include corresponding circuits, such as a power supply module, a motherboard, a front module, a high voltage module, a heating module, a control module, etc., which can be configured as required by those skilled in the art and will not be described in detail herein.
It should be noted that the sample carrier mentioned herein refers to a carrier gas in which a sample to be detected is carried or a combination of the sample and the carrier gas.
The structural arrangement and the working principle of the gas chromatography-ion mobility spectrometer combined system of the present invention are explained below in conjunction with the flow path of the sample carrier gas.
In operation of the instrument, the sample carrier gas removes impurities such as hydrocarbons, oxygen, and water from the carrier gas (e.g., high purity nitrogen) from the gas source 115 and through the in-line purifier 116A and into the instrument gas path of the integrated system 100 through the in-line combination valve 117. The sample carrier gas enters the gas chromatography apparatus 10 after being regulated by the flow regulating valve 118A, and is discharged from the gas chromatography apparatus 10 after being subjected to a pre-separation treatment to form a pre-separated sample carrier gas, and a part of the sample carrier gas enters the second buffer chamber 56 through the first inlet 51 and enters the positive ion transfer tube 21 and the negative ion transfer tube 22 through the first outlet 52 and the second outlet 53, respectively. Specifically, in the positive and negative ion transfer tubes 21 and 22, the sample is ionized by a carrier gas for ion transfer sample introduction, and reaches the faraday plate under the action of a transfer electric field to be detected.
In addition, the remaining portion of the sample carrier gas discharged from the gas chromatography apparatus 10 is discharged from the combined system 100, specifically, is discharged from the combined system 100 into the ambient air after being purified by the purifier 116C in the gas path, so as to avoid the contamination of the positive and negative ion transport tubes 21 and 22 caused by the excessive sample carrier gas entering them.
The drift gases respectively discharged from the positive ion drift tube 21 and the negative ion drift tube 22 first flow into the buffer chamber 31 via the pipes 105 and 106, respectively, after which they are guided out of the buffer chamber 31 via the diaphragm pump 121 by the first branch S1 and are then branched by the three-way valve 122, a part of the drift gases is transported into the first buffer chamber 46 via the inlet pipe by the second branch S2, and the remaining drift gases are discharged out of the combined system by the third branch S3.
A part of the migration gas in the first buffer chamber 46 flows out through the first outlet pipe 41 and the second outlet pipe 42 and is delivered to the positive ion migration pipe 21 and the negative ion migration pipe 22 through the fifth branch S5 and the sixth branch S6, respectively, and another part of the migration gas in the first buffer chamber 46 is delivered to the positive ion migration pipe 21 and the negative ion migration pipe 22 through the third outlet pipe 44 and via the fourth branch S4, the second inlet 54 of the connecting disc air path main body 50, and the inlets of the positive ion migration pipe 21 and the negative ion migration pipe 22.
In the circulating gas path assembly 30, the predetermined flow regulating valve 118B is connected in series to the gas path between the flow buffering four-way component 40 and the connecting disc gas path main body 50, so that the carrier gas and the two paths of migration gas are reasonably distributed.
Specifically, the purpose of equalizing the flow of the migration gas and the sample carrier gas of the positive and negative ion migration tubes can be realized by adjusting and controlling the resistance of the third outlet tube 44 in the gas flow buffering four-way component 40, and the problems of instable instrument spectrogram, baseline jump and the like caused by continuous supplement of high-purity nitrogen carrier gas are avoided. At the same time. The equal diameters of the first outlet pipe 42 and the second outlet pipe 43 in the flow buffering four-way component 40 not only can make the flow rates of the migration gases in the positive and negative ion migration pipes equal, but also can structurally omit at least two flow rate adjusting valves 118 which are originally required to be arranged on the first outlet pipe 42 and the second outlet pipe 43. In addition, the buffer chamber 46 of the four-way airflow buffer component 40 replaces the buffer chamber which is originally needed to be arranged in the air path system, so that the whole structure of the instrument is simpler and more compact, the miniaturized design of the instrument is facilitated, and the cost is saved on the basis of achieving the same effect.
Aiming at the gas chromatography-ion mobility spectrometer combined system provided by the invention, because the airflow buffering four-way component and the connecting disc air passage main body are adopted, on one hand, the two paths of airflow are equally divided, on the other hand, the design of the airflow buffering four-way component and the buffering chambers in the connecting disc air passage main body can avoid the base line jump caused by the airflow interference introduced by the exhaust of the pump, and the equal migration airflow of the dual-mode ion mobility tube can be satisfied; in addition, through the structural design of the connecting disc air passage main body between the positive and negative mode migration tubes, the entering sample carrier gas is buffered, and the quantity entering the positive and negative migration tubes is ensured to be equally divided. The design through above-mentioned two aspects avoids because the structure that leads to through its flow control valve and buffer chamber regulation equals is complicated, and the sample remains to and bulky, the weight is heavy, problem such as with high costs.
Claims (11)
1. A gas chromatography-ion mobility spectrometer combination system comprising:
a gas chromatography device for pre-separating a sample carrier gas to form a pre-separated sample carrier gas;
an ion mobility spectrometer device in fluid communication with the gas chromatography device for detecting the pre-separated sample carrier gas, the ion mobility spectrometer device comprising a positive ion mobility tube and a negative ion mobility tube; and
a circulating gas path component for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after processing the migration gas,
wherein the circulating gas path assembly comprises an airflow buffering four-way component configured to distribute the migration gas flowing into the ion mobility spectrometer and the carrier gas flowing into the ion mobility spectrometer device, wherein the circulation gas path component comprises an airflow buffering four-way component configured to distribute the migration gas flowing into the ion mobility spectrometer and the carrier gas flowing into the ion mobility spectrometer device
The four-way component comprises a first buffer chamber, an inlet pipe communicated with the first buffer chamber, and a first outlet pipe, a second outlet pipe and a third outlet pipe communicated with the first buffer chamber, wherein the four-way component comprises a first buffer chamber, an inlet pipe communicated with the first buffer chamber, a first outlet pipe, a second outlet pipe and a third outlet pipe, and the first outlet pipe, the second outlet pipe and the third outlet pipe are communicated with the first buffer chamber
The inlet pipe, the first outlet pipe, the second outlet pipe and the third outlet pipe are distributed in the same plane around the first buffer chamber at equal intervals, the first outlet pipe and the second outlet pipe are arranged on a first straight line, the inlet pipe and the third outlet pipe are arranged on a second straight line perpendicular to the first straight line,
the circulating gas path assembly further comprises a buffer cavity, a first branch, a second branch, a third branch, a fourth branch, a fifth branch and a sixth branch, wherein the first branch, the second branch and the third branch are connected with each other, and the fourth branch, the fifth branch and the sixth branch are communicated with the gas flow buffer four-way component;
wherein the migration gas discharged from the positive ion transport tube and the negative ion transport tube, respectively, first flows into a buffer chamber, after which the migration gas is guided out of the buffer chamber through a first branch and then branched by a three-way valve, a part of the migration gas is sent into the first buffer chamber through the inlet pipe through a second branch, and the remaining migration gas is discharged out of the combined system through a third branch,
a part of the migration gas in the first buffer chamber flows out through a first outlet pipe and a second outlet pipe respectively and is conveyed to the positive ion migration pipe and the negative ion migration pipe through a fifth branch and a sixth branch, the other part of the migration gas in the first buffer chamber is conveyed to the positive ion migration pipe and the negative ion migration pipe through a third outlet pipe and a fourth branch,
the gas chromatography-ion mobility spectrometer combined system also comprises a connecting disc gas circuit main body, wherein the connecting disc gas circuit main body comprises a second buffer chamber, a first inlet, a first outlet, a second inlet and a second outlet which are respectively communicated with the second buffer chamber,
a part of the sample carrier gas discharged from the gas chromatography apparatus enters the second buffer chamber through the first inlet, and enters the positive ion transfer tube and the negative ion transfer tube through the first outlet and the second outlet, respectively, and the remaining part of the sample carrier gas discharged from the gas chromatography apparatus is discharged out of the combined system.
2. The GC-IMS combination of claim 1, wherein the GC-IMS combination further comprises a coupling agent
The diameters of the first outlet pipe and the second outlet pipe are equal and are larger than the diameter of the third outlet pipe, and the inlet pipe, the first outlet pipe, the second outlet pipe and the third outlet pipe are all provided with inverted cone-shaped structures and connecting threads.
3. The GC-IMS combination of claim 1, wherein the GC-IMS combination further comprises a coupling agent
The first branch is provided with a diaphragm pump for pumping the migration gas into the first branch;
a molecular sieve is arranged on the second branch;
a purifier and a microporous filter membrane are arranged on the third branch;
and a flow regulating valve is arranged on the fourth branch.
4. The GC-IMS combination of claim 1, wherein the GC-IMS combination further comprises a coupling agent
And the circulating carrier gas and the migration gas entering the positive ion migration pipe and the negative ion migration pipe are distributed according to a desired proportion by regulating the resistance of the third outlet pipe.
5. The GC-IMS combination of claim 1, wherein the GC-IMS combination further comprises a coupling agent
The first inlet, the first outlet, the second inlet and the second outlet are distributed in the same plane at equal intervals around the second buffer chamber of the connecting disc air passage main body,
the first and second outlets are arranged on a third line and the first and second inlets are arranged on a fourth line perpendicular to the third line.
6. The GC-IMS combination of claim 5, wherein the GC-IMS combination further comprises a second ion mobility spectrometer, wherein the second ion mobility spectrometer is a mass spectrometer
The diameters of the first outlet and the second outlet are equal, and the first inlet, the first outlet pipe, the second inlet and the second outlet are all provided with inverted cone structures and connecting threads.
7. The GC-IMS combination of claim 1, wherein the GC-IMS combination further comprises a coupling agent
The rest of the sample carrier gas discharged from the gas chromatography device is discharged out of the combined system after being purified by a purifier;
the sample carrier gas is introduced into the gas chromatography apparatus through an inlet of the gas chromatography apparatus through a line provided with a purifier, a combination valve and a regulating valve.
8. A circulating gas path component for an ion mobility spectrometer or a gas chromatography-ion mobility spectrometer combined system is disclosed, wherein,
the circulating gas path component is used for receiving the migration gas exhausted from the ion mobility spectrometer device and circularly conveying the migration gas into the ion mobility spectrometer device after processing the migration gas,
wherein the circulating gas path assembly comprises a gas flow buffer four-way component configured to distribute a migration gas flowing into the ion mobility spectrometer and a carrier gas flowing into the ion mobility spectrometer device, the gas flow buffer four-way component comprising a first buffer chamber, an inlet tube communicating with the first buffer chamber, and a first outlet tube, a second outlet tube, and a third outlet tube communicating with the first buffer chamber, the inlet tube, the first outlet tube, the second outlet tube, and the third outlet tube being equally spaced around the first buffer chamber in the same plane, the first outlet tube and the second outlet tube being arranged in a first straight line, the inlet tube and the third outlet tube being arranged in a second straight line perpendicular to the first straight line.
9. The circulating air path assembly of claim 8,
the first outlet tube and the second outlet tube are of equal diameter.
10. A connecting disc gas path main body for an ion mobility spectrometer or a gas chromatography-ion mobility spectrometer combined system is provided, wherein,
the connecting disc gas circuit main body is arranged between a positive ion migration tube and a negative ion migration tube of the ion mobility spectrometer,
the connecting disc gas circuit main body comprises a second buffer chamber, a first inlet, a first outlet, a second inlet and a second outlet which are respectively communicated with the second buffer chamber,
and the sample carrier gas enters the second buffer chamber through the first inlet and enters the positive ion migration tube and the negative ion migration tube through the first outlet and the second outlet respectively, and the second inlet is connected with a circulating gas circuit component of the ion mobility spectrometer.
11. The land air passage body of claim 10,
the first and second outlets are of equal diameter.
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| CN107907622A (en) * | 2017-12-29 | 2018-04-13 | 同方威视技术股份有限公司 | Gas-chromatography ion mobility spectrometry detector and combined apparatus |
| CN109307724A (en) * | 2018-12-18 | 2019-02-05 | 同方威视技术股份有限公司 | Gas-chromatography-ion mobility spectrometry is combined equipment |
| CN109521081A (en) * | 2018-12-29 | 2019-03-26 | 同方威视技术股份有限公司 | Multifunction ion mobility spectrometer device |
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| CN107907622A (en) * | 2017-12-29 | 2018-04-13 | 同方威视技术股份有限公司 | Gas-chromatography ion mobility spectrometry detector and combined apparatus |
| CN109307724A (en) * | 2018-12-18 | 2019-02-05 | 同方威视技术股份有限公司 | Gas-chromatography-ion mobility spectrometry is combined equipment |
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