CN112294890A - Preparation method and application of compound houttuynia cordata tablets - Google Patents
Preparation method and application of compound houttuynia cordata tablets Download PDFInfo
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- CN112294890A CN112294890A CN202011286231.5A CN202011286231A CN112294890A CN 112294890 A CN112294890 A CN 112294890A CN 202011286231 A CN202011286231 A CN 202011286231A CN 112294890 A CN112294890 A CN 112294890A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a preparation method and application of compound houttuynia cordata tablets, wherein 583 parts by weight of houttuynia cordata, 150 parts by weight of scutellaria baicalensis, 150 parts by weight of isatis root, 58 parts by weight of fructus forsythiae and 58 parts by weight of honeysuckle are taken. This preparation method of compound houttuynia cordata tablet, feeding mechanism and blanking mechanism through setting up in the frame, the overall structure of film clamp is comparatively simple, degree of automation is higher, it is comparatively convenient to use, accomplish the automatic filler processing to the preforming processing, can reduce the powder to a great extent and fill the waste of in-process, reduce the preparation cost of medicine, control swager constructs and liftout mechanism accomplishes the compression moulding and ejecting to the powder, the material pushing frame in the cooperation feeding mechanism sends into the blanking fill with the shaping tablet, the tablet passes through the setting of orifice plate in the blanking fill, let the powder on tablet surface fall into in the collecting hopper and concentrate and be collected, further reduce the waste of powder in the compression moulding process, reduce the preparation cost of tablet.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a compound houttuynia cordata tablet.
Background
Compound houttuynia cordata tablet dictionary, prescription for houttuynia cordata 583g, scutellaria baicalensis 150g, isatis root 150g, forsythia suspensa 58g, honeysuckle 58g, five above-mentioned medicines, taking houttuynia cordata 200g, pulverizing with forsythia suspensa and honeysuckle into fine powder, decocting the rest houttuynia cordata, scutellaria baicalensis and isatis root with water twice, each time for 2 hours, mixing decoctions, filtering, concentrating the filtrate into thick paste, adding the above-mentioned fine powder, uniformly mixing, drying, pulverizing into fine powder, granulating, drying, pressing into 1000 tablets, coating sugar coating so as to obtain the invented product. Can clear away heat and toxic materials, and can be used for treating sore throat caused by affection of exogenous wind-heat; acute pharyngitis and tonsillitis with wind-heat syndrome.
At present, in the process of preparing compound houttuynia cordata tablets, the raw materials of the compound houttuynia cordata tablets are uniformly mixed and dried and then are subjected to tabletting processing, the existing compound houttuynia cordata tablets are subjected to tabletting processing, the structure of tabletting equipment for medicines is complex, the use is inconvenient, the processing efficiency of the medicine tablets is low, in addition, when medicine powder is added into a material pressing groove and in the process of collecting the medicine tablets after the medicine tablets are formed, the waste of a large amount of medicine powder is easily caused, the preparation cost of the medicines is increased, and in order to solve the problems, the technical personnel in the field provide a preparation method and application of the compound houttuynia cordata tablets.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a preparation method of a compound houttuynia cordata tablet and application thereof, and solves the problems that the tablet pressing equipment of a medicine is complex in structure, inconvenient to use and low in processing efficiency of the medicine tablet in the tablet pressing process of the existing compound houttuynia cordata tablet, and in addition, when medicine powder is added into a pressing groove and in the collecting process after the tablet is formed, a large amount of medicine powder is easily wasted, and the medicine preparation cost is increased.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a preparation method of a compound houttuynia cordata tablet specifically comprises the following steps:
step one, 583 parts by weight of houttuynia cordata, 150 parts by weight of scutellaria baicalensis, 150 parts by weight of isatis roots, 58 parts by weight of forsythia and 58 parts by weight of honeysuckle are taken, 200 parts by weight of houttuynia cordata, forsythia and honeysuckle are crushed into fine powder, the rest of houttuynia cordata, scutellaria baicalensis and isatis roots are crushed and mixed, water which is 3 times of the total mass of the mixture is added to prepare a mixed solution, the mixed solution is subjected to ultrasonic extraction for 30min and then subjected to centrifugal treatment, water which is 2 times of the amount of drug residues is added to perform ultrasonic extraction again for 30min and then subjected to centrifugal treatment, the decoction obtained in the two times of extraction is combined and filtered, the filtrate is concentrated into thick paste, the fine powder is added into the thick paste, the fine powder and;
step two, using automatic tablet pressing equipment to perform tablet pressing processing on medicinal powder, subpackaging the medicinal powder into medicinal powder pipes, covering the medicinal powder pipes, starting a feeding mechanism, pushing a movable frame to move towards a workbench by one end of a servo electric cylinder driving shaft, enabling the movable frame to slide inside a sliding frame, displacing the movable frame to be above a forming hole inside a forming plate, closing the servo electric cylinder, pushing a movable frame inside the movable frame to move downwards by two micro electric push rods, driving a plurality of medicinal powder pipes inside the movable frame to move downwards by the movable frame, pushing a notch inside a rubber pad component to be opened by the bottom ends of the plurality of medicinal powder pipes, enabling the medicinal powder inside the medicinal powder pipes to fall into the forming hole, completing automatic filling processing of tablet pressing processing, greatly reducing waste of the medicinal powder in the filling process, reducing preparation cost of medicines, controlling a material pressing mechanism and a material ejecting mechanism to complete compression forming and ejection of the medicinal powder, the two miniature electric push rods drive the movable frame to reset in the movable frame, and the servo electric cylinder drives the movable frame to reset;
step three, starting a material pressing mechanism, wherein the driving end of a material pressing cylinder pushes a material pressing plate to move downwards, the periphery of the inner part of the material pressing plate is respectively connected with the surfaces of four guide pillars in a sliding manner, the bottom end of a material pressing column enters a forming hole, the material pressing column is in a constant-pressure state in the forming hole for 15s by using the driving end of the material pressing cylinder, the pressing forming of tablets is completed, and the driving end of the material pressing cylinder drives the material pressing plate to reset;
step four, starting a material ejecting mechanism, wherein a driving end of an ejecting cylinder pushes an ejecting plate to move upwards, four pull rods drive a fixed frame to move upwards, the top end of an ejecting column and the top end of a forming hole are positioned on the same plane, tablets formed in the forming hole are ejected, a servo electric cylinder is started, a driving end of the servo electric cylinder pushes a movable frame to move towards the right side, and a material pushing frame on the right side of the movable frame pushes the formed tablets to a blanking mechanism;
and step five, enabling the tablets to enter a blanking hopper, enabling the medicinal powder carried on the surfaces of the tablets to fall into a collecting hopper through a pore plate, and enabling the formed tablets to fall into a collecting frame through a conveying hopper to obtain the compound houttuynia cordata tablets.
Preferably, the automatic tabletting equipment comprises a rack, a workbench, a material pressing mechanism, a feeding mechanism, a material ejecting mechanism and a blanking mechanism, wherein the feeding mechanism and the blanking mechanism are arranged on the rack, the feeding mechanism comprises a servo electric cylinder, a sliding frame, a movable frame, a powder medicine pipe, a micro electric push rod and a rubber pad component, the blanking mechanism comprises a blanking hopper, a collecting hopper and a material conveying hopper which are matched with the material pressing mechanism and the material ejecting mechanism, the material pressing mechanism comprises a material pressing plate, a guide pillar and a material pressing pillar, the material ejecting mechanism comprises a fixing frame, a material ejecting plate, a material ejecting pillar, a pull rod and a pull rod sleeve, the whole structure of the tabletting equipment is simpler, the automation degree is higher, the tabletting equipment is more convenient to use, the workbench is fixedly connected inside the rack, the material pressing mechanism is arranged above the workbench, the feeding mechanism is arranged on the left side of the top of the workbench, the material ejecting mechanism is arranged below the, and the right side of workstation is provided with blanking mechanism, the below on frame right side is provided with the collecting frame, the inside fixedly connected with profiled sheeting of workstation, and the inside equidistance of profiled sheeting has seted up a plurality of shaping hole.
Preferably, feeding mechanism includes servo electric jar, carriage, movable frame, medicine powder pipe, miniature electric putter, rubber pad subassembly, and the bottom of carriage and the top fixed connection of workstation, the servo electric jar of left side fixedly connected with at carriage top, and the inside sliding connection of carriage has the movable frame, the one end of servo electric jar drive shaft and the left side fixed connection of movable frame, and the right side fixedly connected with of movable frame push away the material frame, the top of movable frame is provided with the apron, and the equal fixedly connected with miniature electric putter in front and back at apron top, two the one end of miniature electric putter drive shaft all runs through apron and movable frame and extends to the inside of movable frame, and two miniature electric putter drive shafts extend to the equal fixedly connected with movable frame in the inside one end of movable frame.
Preferably, a plurality of screw hole one is seted up to the inside equidistance of adjustable frame, and the equal threaded connection in inside of a plurality of screw hole one has the powder pipe, a plurality of screw hole two is seted up to the bottom of adjustable frame, and the equal threaded connection in inside of a plurality of screw hole two has the rubber pad subassembly, the top surface of rubber pad subassembly and the bottom contact of powder pipe, and the inside of rubber pad subassembly is provided with the incision.
Preferably, the pressing mechanism comprises a pressing plate, guide pillars and pressing pillars, the bottom of the pressing plate is fixedly connected with the pressing pillars, the top of the rack is fixedly connected with a pressing cylinder, the bottom of a driving shaft of the pressing cylinder is fixedly connected with the top of the pressing plate, the periphery of the inside of the workbench is fixedly connected with the guide pillars, and the tops of the four guide pillars are slidably connected with the inside of the pressing plate.
Preferably, the liftout mechanism includes mount, liftout board, liftout post, pull rod cover, and the mount top respectively with the bottom swing joint of four guide pillars all around, the bottom fixedly connected with liftout cylinder of frame, and the top of liftout cylinder drive shaft and the bottom fixed connection of liftout board, the inside equal fixedly connected with pull rod all around of liftout board, and the top of four pull rods all runs through the mount and extends to the top of mount, the equal fixedly connected with pull rod cover all around of workstation bottom, and the inside of four pull rod covers respectively with the top swing joint of four pull rods, the top fixedly connected with a plurality of liftout post of mount.
Preferably, blanking mechanism includes blanking fill, collecting hopper, defeated hopper, and the left side of blanking fill and the right side fixed connection of workstation, the both sides of blanking fill bottom are fixedly connected with collecting hopper and defeated hopper respectively, and the bottom of collecting hopper is enclosed construction, the inside of blanking fill and the top fixedly connected with orifice plate that is located the collecting hopper.
An application of a compound houttuynia cordata tablet in treating acute tonsil is provided.
(III) advantageous effects
The invention provides a preparation method and application of a compound houttuynia cordata tablet. Compared with the prior art, the method has the following beneficial effects:
the preparation method of the compound houttuynia cordata tablets comprises the steps that a feeding mechanism and a blanking mechanism are arranged on a rack, the feeding mechanism comprises a servo electric cylinder, a sliding frame, a movable frame, a medicine powder pipe, a miniature electric push rod and a rubber pad assembly, the blanking mechanism comprises a blanking hopper, a collecting hopper, a conveying hopper, a matching material pressing mechanism and a material ejecting mechanism, the material pressing mechanism comprises a material pressing plate, a guide pillar and a material pressing pillar, the material ejecting mechanism comprises a fixed frame, a material ejecting plate, a material ejecting pillar, a pull rod and a pull rod sleeve, the whole structure of tabletting equipment is simple, the automation degree is high, the tabletting equipment is convenient to use, medicine powder is subpackaged into the medicine powder pipe, the medicine powder pipe is covered, the feeding mechanism is started, one end of a driving shaft of the servo electric cylinder pushes the movable frame to displace in the direction of a workbench, the movable frame slides in the sliding frame, the movable frame displaces to the position above a forming, utilize two miniature electric putter to promote the inside adjustable shelf downstream of adjustable shelf, the adjustable shelf drives inside a plurality of powder pipe downstream, the bottom of a plurality of powder pipe supports the inside incision of rubber pad subassembly open, the inside powder of powder falls into the shaping hole, the completion is to the automatic processing of packing of preforming processing, can reduce the powder in great degree and fill the waste of in-process, reduce the preparation cost of medicine, control swager constructs and expects the mechanism with the top and accomplish the compression moulding and ejecting to powder, the material pushing frame among the cooperation feeding mechanism sends into the blanking fill with the shaping tablet, the tablet passes through the setting of orifice plate in the blanking fill, let the powder on tablet surface fall into the collection hopper and concentrate in being collected, further reduce the waste of powder in the compression moulding process, reduce the cost of preparation of tablet.
Drawings
FIG. 1 is a schematic view of the structure of an automatic sheeting apparatus of the present invention;
FIG. 2 is a schematic view of the feed mechanism of the present invention;
FIG. 3 is a schematic view of the structure of the movable frame and the movable frame according to the present invention;
FIG. 4 is a schematic view of the structure of the movable frame and the pushing frame according to the present invention;
FIG. 5 is a cross-sectional view of the swaging mechanism of the present invention;
FIG. 6 is a schematic view of the structure of the ejector mechanism of the present invention;
FIG. 7 is a schematic view of the blanking mechanism of the present invention;
FIG. 8 is a cross-sectional view of the blanking mechanism of the present invention.
In the figure, 1, a feeding mechanism; 11. a servo electric cylinder; 12. a carriage; 13. a movable frame; 14. a powder tube; 15. a miniature electric push rod; 16. a rubber mat assembly; 17. a material pushing frame; 18. a movable frame; 2. a material pressing mechanism; 21. a material pressing plate; 22. a guide post; 23. pressing the material column; 3. a material ejecting mechanism; 31. a fixed mount; 32. a material ejecting plate; 33. a material ejection column; 34. a pull rod; 35. a pull rod sleeve; 4. a blanking mechanism; 41. a blanking hopper; 42. a collection hopper; 43. a material conveying hopper; 44. an orifice plate; 5. a frame; 6. a work table; 7. a material collecting frame; 8. forming a plate; 9. and (5) forming holes.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1-8, a method for preparing a compound houttuynia cordata tablet specifically includes the following steps:
step one, 583 parts by weight of houttuynia cordata, 150 parts by weight of scutellaria baicalensis, 150 parts by weight of isatis roots, 58 parts by weight of forsythia and 58 parts by weight of honeysuckle are taken, 200 parts by weight of houttuynia cordata, forsythia and honeysuckle are crushed into fine powder, the rest of houttuynia cordata, scutellaria baicalensis and isatis roots are crushed and mixed, water which is 3 times of the total mass of the mixture is added to prepare a mixed solution, the mixed solution is subjected to ultrasonic extraction for 30min and then subjected to centrifugal treatment, water which is 2 times of the amount of drug residues is added to perform ultrasonic extraction again for 30min and then subjected to centrifugal treatment, the decoction obtained in the two times of extraction is combined and filtered, the filtrate is concentrated into thick paste, the fine powder is added into the thick paste, the fine powder and;
step two, using automatic tabletting equipment to carry out tabletting processing on the medicinal powder, subpackaging the medicinal powder into medicinal powder tubes 14, covering a medicine powder tube 14, starting the feeding mechanism 1, pushing a movable frame 13 to move in the direction of a workbench 6 by one end of a driving shaft of a servo electric cylinder 11 to enable the movable frame 13 to slide in a sliding frame 12, moving the movable frame 13 to the position above a forming hole 9 in a forming plate 8, closing the servo electric cylinder 11, pushing a movable frame 18 in the movable frame 13 to move downwards by two micro electric push rods 15, driving a plurality of medicine powder tubes 14 in the movable frame 18 to move downwards, abutting notches in a rubber pad component 16 at the bottom ends of the medicine powder tubes 14, and enabling medicine powder in the medicine powder tubes 14 to fall into the forming hole 9, the automatic filling processing of the tabletting is finished, the two miniature electric push rods 15 drive the movable frame 18 to reset in the movable frame 13, and the servo electric cylinder 11 drives the movable frame 13 to reset;
step three, starting the material pressing mechanism 2, pushing the material pressing plate 21 to move downwards by the driving end of the material pressing cylinder, enabling the periphery inside the material pressing plate 21 to be in sliding connection with the surfaces of the four guide pillars 22 respectively, enabling the bottom end of the material pressing column 23 to enter the forming hole 9, enabling the material pressing column 23 to be in a constant pressure state in the forming hole 9 by the driving end of the material pressing cylinder, lasting for 10s, completing the press forming of tablets, and driving the material pressing plate 21 to reset by the driving end of the material pressing cylinder;
step four, starting the ejection mechanism 3, wherein the driving end of an ejection cylinder pushes an ejection plate 32 to move upwards, four pull rods 34 drive a fixed frame 31 to move upwards, the top end of an ejection column 33 and the top end of a forming hole 9 are positioned on the same plane, tablets formed in the forming hole 9 are pushed out, a servo electric cylinder 11 is started, the driving end of the servo electric cylinder 11 pushes a movable frame 13 to move to the right side, and a material pushing frame 17 on the right side of the movable frame 13 pushes the formed tablets into a blanking mechanism 4;
and step five, the tablets enter a blanking hopper 41, the medicinal powder carried on the surfaces of the tablets falls into a collecting hopper 42 through a pore plate 44, and the formed tablets fall into a collecting frame 7 through a conveying hopper 43 to obtain the compound houttuynia cordata tablets.
Example 2
Referring to fig. 1-8, a method for preparing a compound houttuynia cordata tablet specifically includes the following steps:
step one, 583 parts by weight of houttuynia cordata, 150 parts by weight of scutellaria baicalensis, 150 parts by weight of isatis roots, 58 parts by weight of forsythia and 58 parts by weight of honeysuckle are taken, 200 parts by weight of houttuynia cordata, forsythia and honeysuckle are crushed into fine powder, the rest of houttuynia cordata, scutellaria baicalensis and isatis roots are crushed and mixed, water which is 3 times of the total mass of the mixture is added to prepare a mixed solution, the mixed solution is subjected to ultrasonic extraction for 30min and then subjected to centrifugal treatment, water which is 2 times of the amount of drug residues is added to perform ultrasonic extraction again for 30min and then subjected to centrifugal treatment, the decoction obtained in the two times of extraction is combined and filtered, the filtrate is concentrated into thick paste, the fine powder is added into the thick paste, the fine powder and;
step two, using automatic tabletting equipment to carry out tabletting processing on the medicinal powder, subpackaging the medicinal powder into medicinal powder tubes 14, covering a medicine powder tube 14, starting the feeding mechanism 1, pushing a movable frame 13 to move in the direction of a workbench 6 by one end of a driving shaft of a servo electric cylinder 11 to enable the movable frame 13 to slide in a sliding frame 12, moving the movable frame 13 to the position above a forming hole 9 in a forming plate 8, closing the servo electric cylinder 11, pushing a movable frame 18 in the movable frame 13 to move downwards by two micro electric push rods 15, driving a plurality of medicine powder tubes 14 in the movable frame 18 to move downwards, abutting notches in a rubber pad component 16 at the bottom ends of the medicine powder tubes 14, and enabling medicine powder in the medicine powder tubes 14 to fall into the forming hole 9, the automatic filling processing of the tabletting is finished, the two miniature electric push rods 15 drive the movable frame 18 to reset in the movable frame 13, and the servo electric cylinder 11 drives the movable frame 13 to reset;
step three, starting the material pressing mechanism 2, pushing the material pressing plate 21 to move downwards by the driving end of the material pressing cylinder, enabling the periphery inside the material pressing plate 21 to be in sliding connection with the surfaces of the four guide pillars 22 respectively, enabling the bottom end of the material pressing column 23 to enter the forming hole 9, enabling the material pressing column 23 to be in a constant pressure state in the forming hole 9 by the driving end of the material pressing cylinder, lasting for 15s, completing the press forming of tablets, and driving the material pressing plate 21 to reset by the driving end of the material pressing cylinder;
step four, starting the ejection mechanism 3, wherein the driving end of an ejection cylinder pushes an ejection plate 32 to move upwards, four pull rods 34 drive a fixed frame 31 to move upwards, the top end of an ejection column 33 and the top end of a forming hole 9 are positioned on the same plane, tablets formed in the forming hole 9 are pushed out, a servo electric cylinder 11 is started, the driving end of the servo electric cylinder 11 pushes a movable frame 13 to move to the right side, and a material pushing frame 17 on the right side of the movable frame 13 pushes the formed tablets into a blanking mechanism 4;
and step five, the tablets enter a blanking hopper 41, the medicinal powder carried on the surfaces of the tablets falls into a collecting hopper 42 through a pore plate 44, and the formed tablets fall into a collecting frame 7 through a conveying hopper 43 to obtain the compound houttuynia cordata tablets.
Example 3
Referring to fig. 1-8, the automatic tablet pressing device includes a frame 5, a workbench 6, a pressing mechanism 2, a feeding mechanism 1, an ejecting mechanism 3, and a blanking mechanism 4, and the inside of the frame 5 is fixedly connected with the workbench 6, the pressing mechanism 2 is arranged above the workbench 6, the feeding mechanism 1 is arranged on the left side of the top of the workbench 6, the ejecting mechanism 3 is arranged below the workbench 6, the blanking mechanism 4 is arranged on the right side of the workbench 6, a material collecting frame 7 is arranged below the right side of the frame 5, a forming plate 8 is fixedly connected inside the workbench 6, and a plurality of forming holes 9 are formed in the forming plate 8 at equal intervals.
A plurality of screw hole I has been seted up to the inside equidistance of adjustable frame 18, and the equal threaded connection in inside of a plurality of screw hole I has powder pipe 14, and a plurality of screw hole II has been seted up to the bottom of adjustable frame 13, and the equal threaded connection in inside of a plurality of screw hole II has rubber pad subassembly 16, the top surface of rubber pad subassembly 16 and the bottom contact of powder pipe 14, and the inside of rubber pad subassembly 16 is provided with the incision.
The material pressing mechanism 2 comprises a material pressing plate 21, guide pillars 22 and material pressing pillars 23, the bottom of the material pressing plate 21 is fixedly connected with the material pressing pillars 23, the top of the frame 5 is fixedly connected with a material pressing cylinder, the bottom of a driving shaft of the material pressing cylinder is fixedly connected with the top of the material pressing plate 21, the periphery inside the workbench 6 is fixedly connected with the guide pillars 22, and the top ends of the four guide pillars 22 are connected with the material pressing plate 21 in a sliding mode.
The blanking mechanism 4 comprises a blanking hopper 41, a collecting hopper 42 and a conveying hopper 43, the left side of the blanking hopper 41 is fixedly connected with the right side of the workbench 6, the two sides of the bottom of the blanking hopper 41 are respectively and fixedly connected with the collecting hopper 42 and the conveying hopper 43, the bottom end of the collecting hopper 42 is of a closed structure, and the inside of the blanking hopper 41 is fixedly connected with a pore plate 44 at the top of the collecting hopper 42.
An application of a compound herba Houttuyniae tablet in treating acute tonsil is provided.
And those not described in detail in this specification are well within the skill of those in the art.
The working principle of the automatic tabletting equipment is as follows:
when the automatic filling device is used, powder is subpackaged into the powder tubes 14, the powder tubes 14 are covered, the feeding mechanism 1 is started, one end of a driving shaft of the servo electric cylinder 11 pushes the movable frame 13 to move towards the workbench 6, the movable frame 13 slides inside the sliding frame 12, the movable frame 13 moves to the position above the forming hole 9 inside the forming plate 8, the servo electric cylinder 11 is closed, the movable frame 18 inside the movable frame 13 is pushed to move downwards by the aid of the two micro electric push rods 15, the movable frame 18 drives the powder tubes 14 inside the movable frame 13 to move downwards, notches inside the rubber pad assemblies 16 are abutted by the bottoms of the powder tubes 14, powder inside the powder tubes 14 falls into the forming hole 9, automatic filling processing of tabletting is completed, the two micro electric push rods 15 drive the movable frame 18 to reset in the movable frame 13, and the servo electric cylinder 11 drives the movable frame 13 to reset;
starting the material pressing mechanism 2, pushing the material pressing plate 21 to move downwards by the driving end of the material pressing cylinder, enabling the periphery inside the material pressing plate 21 to be in sliding connection with the surfaces of the four guide pillars 22 respectively, enabling the bottom end of the material pressing column 23 to enter the forming hole 9, enabling the material pressing column 23 to be in a constant-pressure state in the forming hole 9 by the driving end of the material pressing cylinder, lasting for 15s, completing the press forming of tablets, and enabling the driving end of the material pressing cylinder to drive the material pressing plate 21 to reset; start liftout mechanism 3, liftout cylinder drive end promotes liftout board 32 upward displacement, four pull rods 34 drive mount 31 rebound, the top of liftout post 33 and the top of shaping hole 9 are in the coplanar, the fashioned tablet is supported out in the shaping hole 9, start servo electric jar 11, servo electric jar 11 drive end promotes movable frame 13 to the right side displacement, the material pushing frame 17 on movable frame 13 right side pushes away the shaping tablet to blanking mechanism 4, the tablet gets into blanking hopper 41, the powder that the tablet surface carried falls into collecting hopper 42 through orifice plate 44, the shaping tablet falls into collecting hopper 7 through defeated hopper 43, obtain compound houttuynia cordata piece.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A preparation method of compound houttuynia cordata tablets is characterized by comprising the following steps: the method specifically comprises the following steps:
step one, 583 parts by weight of houttuynia cordata, 150 parts by weight of scutellaria baicalensis, 150 parts by weight of isatis roots, 58 parts by weight of forsythia and 58 parts by weight of honeysuckle are taken, 200 parts by weight of houttuynia cordata, forsythia and honeysuckle are crushed into fine powder, the rest of houttuynia cordata, scutellaria baicalensis and isatis roots are crushed and mixed, water which is 3 times of the total mass of the mixture is added to prepare a mixed solution, the mixed solution is subjected to ultrasonic extraction for 30min and then subjected to centrifugal treatment, water which is 2 times of the amount of drug residues is added to perform ultrasonic extraction again for 30min and then subjected to centrifugal treatment, the decoction obtained in the two times of extraction is combined and filtered, the filtrate is concentrated into thick paste, the fine powder is added into the thick paste, the fine powder and;
secondly, tabletting the medicinal powder by using automatic tabletting equipment, subpackaging the medicinal powder into medicinal powder tubes (14), covering the medicinal powder tubes (14), starting the feeding mechanism (1), pushing a movable frame (13) to move towards a workbench (6) by one end of a driving shaft of a servo electric cylinder (11), enabling the movable frame (13) to slide in a sliding frame (12), enabling the movable frame (13) to move to the upper part of a forming hole (9) in a forming plate (8), closing the servo electric cylinder (11), pushing the movable frame (18) in the movable frame (13) to move downwards by using two miniature electric push rods (15), driving a plurality of medicinal powder tubes (14) in the movable frame (18) to move downwards, abutting notches in a rubber pad assembly (16) by the bottom ends of the plurality of medicinal powder tubes (14), enabling the medicinal powder in the medicinal powder tubes (14) to fall into the forming hole (9), and finishing automatic filling processing of tabletting, two miniature electric push rods (15) drive the movable frame (18) to reset in the movable frame (13), and the servo electric cylinder (11) drives the movable frame (13) to reset;
step three, starting a material pressing mechanism (2), pushing a material pressing plate (21) to move downwards by a driving end of a material pressing cylinder, enabling the periphery of the interior of the material pressing plate (21) to be in sliding connection with the surfaces of four guide pillars (22) respectively, enabling the bottom end of a material pressing column (23) to enter a forming hole (9), enabling the material pressing column (23) to be in a constant pressure state in the forming hole (9) by the driving end of the material pressing cylinder, lasting for 10-15s, completing the press forming of tablets, and driving the material pressing plate (21) to reset by the driving end of the material pressing cylinder;
fourthly, starting the material ejecting mechanism (3), wherein the driving end of an ejecting cylinder pushes an ejecting plate (32) to move upwards, four pull rods (34) drive a fixed frame (31) to move upwards, the top end of an ejecting column (33) and the top end of a forming hole (9) are positioned on the same plane, tablets formed in the forming hole (9) are pushed out, a servo electric cylinder (11) is started, the driving end of the servo electric cylinder (11) pushes a movable frame (13) to move to the right side, and a material pushing frame (17) on the right side of the movable frame (13) pushes the formed tablets to the blanking mechanism (4);
and step five, the tablets enter a blanking hopper (41), the medicinal powder carried on the surfaces of the tablets falls into a collecting hopper (42) through a pore plate (44), and the formed tablets fall into a collecting frame (7) through a conveying hopper (43) to obtain the compound houttuynia cordata tablets.
2. The preparation method of the compound houttuynia cordata tablet according to claim 1, which is characterized by comprising the following steps: automatic tabletting equipment includes frame (5), workstation (6), swager constructs (2), feeding mechanism (1), liftout mechanism (3), blanking mechanism (4), and inside fixedly connected with workstation (6) of frame (5), the top of workstation (6) is provided with swager constructs (2), and the left side at workstation (6) top is provided with feeding mechanism (1), the below of workstation (6) is provided with liftout mechanism (3), and the right side of workstation (6) is provided with blanking mechanism (4), the below on frame (5) right side is provided with material collecting frame (7), the inside fixedly connected with profiled sheeting (8) of workstation (6), and a plurality of shaping hole (9) have been seted up to the inside equidistance of profiled sheeting (8).
3. The preparation method of the compound houttuynia cordata tablets according to claim 2, which is characterized by comprising the following steps: the feeding mechanism (1) comprises a servo electric cylinder (11), a sliding frame (12), a movable frame (13), a medicine powder pipe (14), a micro electric push rod (15) and a rubber pad assembly (16), the bottom of the sliding frame (12) is fixedly connected with the top of a workbench (6), the left side of the top of the sliding frame (12) is fixedly connected with the servo electric cylinder (11), the inner part of the sliding frame (12) is slidably connected with the movable frame (13), one end of a driving shaft of the servo electric cylinder (11) is fixedly connected with the left side of the movable frame (13), the right side of the movable frame (13) is fixedly connected with a material pushing frame (17), the top of the movable frame (13) is provided with a cover plate, the front and the rear of the top of the cover plate are fixedly connected with the micro electric push rod (15), one end of the driving shaft of the two micro electric push rods (15) penetrates through the cover plate and the movable frame (13) and, and one ends of the driving shafts of the two miniature electric push rods (15) extending to the interior of the movable frame (13) are fixedly connected with movable frames (18).
4. The preparation method of the compound houttuynia cordata tablets according to claim 3, which is characterized by comprising the following steps: a plurality of screw hole one is seted up to the inside equidistance of adjustable shelf (18), and the equal threaded connection in inside of a plurality of screw hole one has powder pipe (14), a plurality of screw hole two has been seted up to the bottom of movable frame (13), and the equal threaded connection in inside of a plurality of screw hole two has rubber pad subassembly (16), the top surface of rubber pad subassembly (16) contacts with the bottom of powder pipe (14), and the inside of rubber pad subassembly (16) is provided with the incision.
5. The preparation method of the compound houttuynia cordata tablets according to claim 2, which is characterized by comprising the following steps: the material pressing mechanism (2) comprises a material pressing plate (21), guide pillars (22) and material pressing columns (23), the bottom of the material pressing plate (21) is fixedly connected with the material pressing columns (23), the top of the rack (5) is fixedly connected with a material pressing cylinder, the bottom of a driving shaft of the material pressing cylinder is fixedly connected with the top of the material pressing plate (21), the guide pillars (22) are fixedly connected to the periphery of the inside of the workbench (6), and the tops of the four guide pillars (22) are connected with the inside of the material pressing plate (21) in a sliding mode.
6. The preparation method of the compound houttuynia cordata tablets according to claim 2, which is characterized by comprising the following steps: the ejection mechanism (3) comprises a fixed frame (31), an ejection plate (32), an ejection column (33), a pull rod (34) and a pull rod sleeve (35), the periphery of the top of the fixed frame (31) is respectively movably connected with the bottom ends of the four guide posts (22), the bottom of the frame (5) is fixedly connected with a material ejecting cylinder, the top end of the driving shaft of the material ejecting cylinder is fixedly connected with the bottom of the material ejecting plate (32), the periphery inside the material ejecting plate (32) is fixedly connected with pull rods (34), the top ends of the four pull rods (34) penetrate through the fixed frame (31) and extend to the top of the fixed frame (31), pull rod sleeves (35) are fixedly connected around the bottom of the workbench (6), and the insides of the four pull rod sleeves (35) are respectively movably connected with the top ends of the four pull rods (34), the top of the fixed frame (31) is fixedly connected with a plurality of material ejection columns (33).
7. The preparation method of the compound houttuynia cordata tablets according to claim 2, which is characterized by comprising the following steps: blanking mechanism (4) are including blanking hopper (41), collecting hopper (42), defeated hopper (43), and the left side of blanking hopper (41) and the right side fixed connection of workstation (6), the both sides of blanking hopper (41) bottom are fixedly connected with collecting hopper (42) and defeated hopper (43) respectively, and the bottom of collecting hopper (42) is enclosed construction, the inside of blanking hopper (41) and the top fixedly connected with orifice plate (44) that are located collecting hopper (42).
8. The application of the compound houttuynia cordata tablets is characterized in that: the compound houttuynia cordata tablets are applied to the treatment of acute tonsil.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011286231.5A CN112294890A (en) | 2020-11-17 | 2020-11-17 | Preparation method and application of compound houttuynia cordata tablets |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011286231.5A CN112294890A (en) | 2020-11-17 | 2020-11-17 | Preparation method and application of compound houttuynia cordata tablets |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113509389A (en) * | 2021-04-14 | 2021-10-19 | 何开用 | Tablet compression forming equipment for bioengineering |
| CN113975177A (en) * | 2021-10-22 | 2022-01-28 | 景时(杭州)药业有限公司 | Tadalafil powder direct-compression tableting equipment and tableting method thereof |
| CN114013093A (en) * | 2021-10-28 | 2022-02-08 | 南京恒士丹电气设备有限公司 | Intelligent environment-friendly energy-saving medicine processing machine |
| CN116512658A (en) * | 2023-06-29 | 2023-08-01 | 南京佳熙康德医药科技有限公司 | Intelligent production system and production method for vitamin C |
-
2020
- 2020-11-17 CN CN202011286231.5A patent/CN112294890A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113509389A (en) * | 2021-04-14 | 2021-10-19 | 何开用 | Tablet compression forming equipment for bioengineering |
| CN113509389B (en) * | 2021-04-14 | 2023-11-24 | 广州市雅博生物科技有限公司 | Tablet press forming equipment for bioengineering |
| CN113975177A (en) * | 2021-10-22 | 2022-01-28 | 景时(杭州)药业有限公司 | Tadalafil powder direct-compression tableting equipment and tableting method thereof |
| CN114013093A (en) * | 2021-10-28 | 2022-02-08 | 南京恒士丹电气设备有限公司 | Intelligent environment-friendly energy-saving medicine processing machine |
| CN116512658A (en) * | 2023-06-29 | 2023-08-01 | 南京佳熙康德医药科技有限公司 | Intelligent production system and production method for vitamin C |
| CN116512658B (en) * | 2023-06-29 | 2024-01-02 | 南京佳熙康德医药科技有限公司 | Intelligent production system and production method for vitamin C |
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