CN112262778B - Feeding inhibition experimental device for rat/mouse new environment - Google Patents
Feeding inhibition experimental device for rat/mouse new environment Download PDFInfo
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- CN112262778B CN112262778B CN202010946162.XA CN202010946162A CN112262778B CN 112262778 B CN112262778 B CN 112262778B CN 202010946162 A CN202010946162 A CN 202010946162A CN 112262778 B CN112262778 B CN 112262778B
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- 230000005764 inhibitory process Effects 0.000 title claims abstract description 16
- 235000013305 food Nutrition 0.000 claims abstract description 24
- 241000700159 Rattus Species 0.000 claims description 54
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 44
- 241000699670 Mus sp. Species 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 12
- 238000012360 testing method Methods 0.000 claims description 7
- 239000010902 straw Substances 0.000 claims description 6
- 238000004088 simulation Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims 1
- 238000002474 experimental method Methods 0.000 abstract description 10
- 238000013459 approach Methods 0.000 abstract description 8
- 208000019901 Anxiety disease Diseases 0.000 abstract description 5
- 208000020401 Depressive disease Diseases 0.000 abstract description 2
- 238000000429 assembly Methods 0.000 abstract 2
- 230000000712 assembly Effects 0.000 abstract 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 6
- 239000006187 pill Substances 0.000 description 5
- 230000036506 anxiety Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000012774 insulation material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
- A01K1/0356—Feeding or drinking devices associated with cages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G17/00—Apparatus for or methods of weighing material of special form or property
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V8/00—Prospecting or detecting by optical means
- G01V8/10—Detecting, e.g. by using light barriers
- G01V8/20—Detecting, e.g. by using light barriers using multiple transmitters or receivers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geophysics (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Catching Or Destruction (AREA)
Abstract
The invention discloses a rat/mouse new environment feeding inhibition experiment device which comprises a closed box for accommodating a rat/mouse, food which is positioned in the closed box and induces the rat/mouse to eat, a sensor for detecting whether the rat/mouse approaches the food, and a central controller electrically connected with the sensor, wherein the sensor comprises an outer shell, weight sensors and a support frame, a plurality of the weight sensors are respectively fixed on the periphery inside the outer shell, the support frame is fixed in the center of the top surface of the outer shell, the food is positioned on the support frame, the sensor further comprises an infrared detector, the infrared detector comprises an infrared transmitting assembly and an infrared receiving assembly, the infrared transmitting assemblies are respectively arranged in an inner cavity of the outer shell and upwards transmit infrared rays, and the infrared receiving assemblies are respectively fixed on the bottom surface of the top plate of the closed box and can eliminate artificial interference, so that the anxiety state or depression state of the rat/mouse can be correctly reflected.
Description
[ technical field ] A
The invention relates to the technical field of animal science experiments and research devices, in particular to the technical field of a rat/mouse new environment feeding inhibition experiment device.
[ background ] A method for producing a semiconductor device
Currently, people often reflect anxiety or depression states in rats/mice by observing their behavior in approaching and eating food in new environments. However, the behavior of experimenters approaching to rats/mice many times and manually observing in the experimental process is very easy to influence the states of the rats/mice, resulting in deviation of experimental results, and the experimental results are difficult to quantify, so that a solution is needed.
[ summary of the invention ]
The invention aims to solve the problems in the prior art and provides a feeding inhibition experimental device for a rat/mouse new environment, which can eliminate artificial interference, judge, record and quantify the feeding condition of the rat/mouse, and thus correctly reflect the anxiety or depression state of the rat/mouse.
In order to achieve the purpose, the invention provides a rat/mouse new environment feeding inhibition experiment device which comprises a closed box for accommodating the entering of a rat/mouse, food which is positioned in the closed box and induces the rat/mouse to eat, a sensor for detecting whether the rat/mouse approaches the food, and a central controller electrically connected with the sensor.
Preferably, the airtight box comprises a box body, a box door and a base, wherein the box body is provided with a plurality of air holes, the box door is fixed on an opening in the side wall of the box body, the base is fixed at the bottom of the box body, and the central controller is located in the base.
Preferably, the sensor comprises an outer shell, a plurality of weight sensors and a support frame, the weight sensors are respectively fixed to the periphery of the inner portion of the outer shell, the support frame is fixed to the center of the top face of the outer shell, and the food is fixed to the top end of the support frame.
Preferably, the support frame includes pedestal, support body and spring, the main part of pedestal is the column and the top is equipped with the accepting of bowl form, the top central authorities of pedestal are equipped with the blind hole that runs through accepting and main part downwards, the hole bottom at the blind hole is fixed to the one end of spring, the other end of spring is then fixed at the bottom surface central authorities of support body, the support body is the dress of bowl, the opening of accepting and support body is all up, the top surface of support body is equipped with a plurality of beads, food is pasted and is fixed on the support body.
As preferred, the sensor still includes infrared detector, infrared detector includes infrared emission subassembly and infrared ray receiving component, a plurality of infrared emission subassembly sets up respectively in the inner chamber of shell body and upwards launches the infrared ray, it is equipped with the through-hole that a plurality of supplied infrared ray passed to surround the support frame on the roof of shell body, it has the light-passing board to seal in the through-hole, a plurality of infrared ray receiving component fixes respectively in the roof bottom surface of seal box and with infrared emission subassembly one-to-one, the bottom plate top surface central authorities at the seal box are fixed to the shell body.
Preferably, a monitoring camera is fixed in the closed box and electrically connected with the central controller.
Preferably, a plurality of illuminating lamps are fixed in the closed box and electrically connected with the central controller.
Preferably, the top surface of the bottom plate of the closed box is paved with a simulated straw mat, and the sensor and the food are both positioned on the simulated straw mat.
Preferably, a display screen is fixed on the outer wall of the closed box and electrically connected with the central controller.
Preferably, the central controller is further provided with a wireless communication module, and the central controller is in communication connection with a mobile phone or a computer of an experimenter through the wireless communication module.
The invention has the beneficial effects that: according to the invention, the rat/mouse is placed in the closed box, so that the artificial interference is eliminated, the weight sensor is utilized to monitor whether the rat/mouse climbs up the outer shell in real time, meanwhile, the infrared detector is utilized to further monitor whether the rat/mouse is close to food, and the eating condition of the rat/mouse is judged, recorded and quantified, so that the anxiety or depression state of the rat/mouse is correctly reflected; by arranging the monitoring camera, experimenters can conveniently and directly observe rats/mice in the box body; by arranging the display screen and the wireless communication module, experimenters can conveniently know the eating condition of rats/mice remotely outside the box; the base body, the support body and the spring are arranged to form the support frame, so that the sugar pill can move in a certain range by utilizing the spring when being stuck and fixed on the support body, and is convenient for rats/mice to take; the plurality of convex edges are arranged on the support body, so that the contact area of the glue and the support body is increased, and the connection strength of the sugar pill and the support body is enhanced.
The features and advantages of the present invention will be described in detail by embodiments in conjunction with the accompanying drawings.
[ description of the drawings ]
FIG. 1 is a front sectional view of a rat/mouse feeding inhibition experiment device in a new environment;
FIG. 2 is a top view of a sensor of the rat/mouse new environment feeding inhibition experiment device according to the present invention;
FIG. 3 is a front cross-sectional view of the support frame of the experiment device for suppressing feeding in rat/mouse new environment
In the figure: 1-closed box, 11-box body, 111-air vent, 12-box door, 13-base, 2-central controller, 3-sensor, 31-outer shell, 311-through hole, 32-weight sensor, 33-support frame, 331-base, 3311-accepting part, 3312-blind hole, 332-support body, 3321-convex edge, 333-spring, 34-infrared emission component, 35-infrared receiving component, 4-food, 5-monitoring camera, 6-lighting lamp, 7-simulated grass mat and 8-display screen.
[ detailed description ] A
Referring to fig. 1, 2 and 3, the rat/mouse new environment feeding inhibition experiment device of the present invention includes an airtight box 1 for accommodating the rat/mouse, food 4 located in the airtight box 1 for inducing the rat/mouse to eat, a sensor 3 for detecting whether the rat/mouse approaches the food 4, and a central controller 2 electrically connected to the sensor 3.
The closed box 1 comprises a box body 11, a box door 12 and a base 13, wherein the box body 11 is provided with a plurality of air holes 111, the box door 12 is fixed on an opening on the side wall of the box body 11, the base 13 is fixed at the bottom of the box body 11, and the central controller 2 is positioned in the base 13.
The sensor 3 comprises an outer shell 31, a weight sensor 32 and a support frame 33, wherein the weight sensors 32 are respectively fixed around the inside of the outer shell 31, the support frame 33 is fixed at the center of the top surface of the outer shell 31, and the food 4 is fixed at the top end of the support frame 33.
The support frame 33 includes pedestal 331, the support body 332 and spring 333, the main part of pedestal 331 is the column and the top is equipped with the portion of acceptance 3311 of bowl form, the top central authorities of pedestal 331 are equipped with the blind hole 3312 of running through the portion of acceptance 3311 and main part downwards, the bottom of hole at blind hole 3312 is fixed to the one end of spring 333, the other end of spring 333 is then fixed at the bottom surface central authorities of the support body 332, the support body 332 is the dress of bowl, the opening of portion of acceptance 3311 and the support body 332 all up, the top surface of the support body 332 is equipped with a plurality of beads 3321, food 4 pastes and fixes on the support body 332.
Sensor 3 still includes infrared detector, infrared detector includes infrared emission subassembly 34 and infrared ray receiving subassembly 35, a plurality of infrared emission subassembly 34 sets up respectively in the inner chamber of shell body 31 and upwards launches the infrared ray, it is equipped with the through-hole 311 that a plurality of confession infrared ray passed to encircle support frame 33 on the roof of shell body 31, through-hole 311 is internal to be sealed has light-passing board, a plurality of infrared ray receiving subassembly 35 fix respectively in the roof bottom surface of seal box 1 and with infrared emission subassembly 34 one-to-one, the bottom plate top surface central authorities at seal box 1 are fixed to shell body 31.
A monitoring camera 5 is fixed in the closed box 1, and the monitoring camera 5 is electrically connected with the central controller 2.
A plurality of illuminating lamps 6 are fixed in the closed box 1, and the illuminating lamps 6 are electrically connected with the central controller 2.
The simulation straw mat 7 is laid on the top surface of the bottom plate of the closed box 1, and the sensor 3 and the food 4 are both located on the simulation straw mat 7.
And a display screen 8 is fixed on the outer wall of the closed box 1, and the display screen 8 is electrically connected with the central controller 2.
The central controller 2 is also provided with a wireless communication module, and the central controller 2 is in communication connection with a mobile phone or a computer of an experimenter through the wireless communication module.
The working process of the invention is as follows:
taking the anxiety/depression behavior test of rats/mice as an example, 4 enclosures were placed in a quiet and undisturbed room, one rat/mouse was placed in each enclosure, and the rats/mice were fasted for 24h before the test. Wherein, the box body 11 is made of gray foam sound insulation material, the thickness is 1-3 cm, the size is 60cm long, 60cm wide and 50cm high; the outer shell 31 is cylindrical and has an outer diameter of 15cm; the food 4 is in the form of sugar pills and is fixed on the top of the holder body 332.
During the experiment, the weight sensor 32 monitors the weight change over the outer case 31 of the sensor 3 in real time and transmits the data to the central controller 2, thereby determining whether the rat/mouse climbs up the outer case 31. Meanwhile, the infrared emitting component 34 and the infrared receiving component 35 are matched with each other, and whether the rat/mouse is close to the support frame 33 or not is monitored in real time by using infrared rays. When the weight sensor 32 and the infrared detector detect the mouse/rat at the same time, the approach of the mouse/rat to the food 4 is recorded once, and the time when the mouse/rat approaches is recorded. The display screen 8 displays data on the approach of the rat/mouse to the food 4, such as the total approach duration and the total approach times. During the period, the central controller 2 directly transmits the monitoring data to a mobile phone or a computer of a tester through the wireless communication module. The experimenter can also directly observe the big/mouse condition in the box body 11 through the monitoring camera 5.
According to the method, the rat/mouse is placed in the closed box, the artificial interference is eliminated, the weight sensor is used for monitoring whether the rat/mouse climbs the outer shell in real time, meanwhile, the infrared detector is used for further monitoring whether the rat/mouse is close to food, and the eating condition of the rat/mouse is judged, recorded and quantified, so that the anxiety state or the depression state of the rat/mouse is correctly reflected; the monitoring camera is arranged, so that an experimenter can directly observe the big mouse or the mouse in the box body; by arranging the display screen and the wireless communication module, experimenters can conveniently know the eating condition of rats/mice remotely outside the box; the base body, the support body and the spring are arranged to form the support frame, so that the sugar pill can move in a certain range by utilizing the spring when being stuck and fixed on the support body, and is convenient for rats/mice to take; the plurality of convex edges are arranged on the support body, so that the contact area of the glue and the support body is increased, and the connection strength of the sugar pill and the support body is enhanced.
The above embodiments are illustrative of the present invention, and are not intended to limit the present invention, and any simple modifications of the present invention are within the scope of the present invention.
Claims (7)
1. A rat/mouse new environment feeding inhibition experimental device is characterized in that: the rat/mouse bait box comprises a closed box (1) for accommodating rats/mice, food (4) which is positioned in the closed box (1) and lures the rats/mice to eat, a sensor (3) for detecting whether the rats/mice are close to the food (4) and a central controller (2) which is electrically connected with the sensor (3), wherein the sensor (3) comprises a shell body (31), a weight sensor (32) and a support frame (33), a plurality of weight sensors (32) are respectively fixed on the periphery of the inner part of the shell body (31), the support frame (33) is fixed on the center of the top surface of the shell body (31), the food (4) is fixed at the top end of the support frame (33), the support frame (33) comprises a base body (331), a support body (332) and a spring (333), the main body of the base body (331) is columnar, a bowl-shaped support part (3311) is arranged at the top end, the blind hole (3312) which penetrates through the support part (3311) and the main body is arranged at the top center of the base body (331), one end of the spring (333) is fixed at the bottom of the blind hole (3312), a plurality of support strips (3311) which are arranged and a plurality of support strips (332) which are arranged and are respectively provided with openings (332, 33121, and a plurality of convex ribs (332) which are arranged on the support strips (332) and a plurality of support strips (332), food (4) are pasted and are fixed on support body (332), sensor (3) still include infrared detector, infrared detector includes infrared emission subassembly (34) and infrared ray receiving component (35), a plurality of infrared emission subassembly (34) set up respectively in the inner chamber of shell body (31) and upwards launch the infrared ray, it supplies through-hole (311) that the infrared ray passed to surround support frame (33) to be equipped with a plurality of on the roof of shell body (31), the through-hole (311) are inside sealed to have a light-passing board, a plurality of infrared ray receiving component (35) are fixed respectively in the roof bottom surface of seal box (1) and with infrared ray emitting component (34) one-to-one, bottom plate top surface central authorities in seal box (1) are fixed in shell body (31).
2. The experimental apparatus for inhibition of feeding in rat/mouse new environment as set forth in claim 1, wherein: the sealing box (1) comprises a box body (11), a box door (12) and a base (13), wherein a plurality of air holes (111) are formed in the box body (11), the box door (12) is fixed to an opening in the side wall of the box body (11), the base (13) is fixed to the bottom of the box body (11), and the central controller (2) is located in the base (13).
3. The rat/mouse new environment feeding inhibition test device according to claim 1, wherein: a monitoring camera (5) is fixed in the closed box (1), and the monitoring camera (5) is electrically connected with the central controller (2).
4. The rat/mouse new environment feeding inhibition test device according to claim 1, wherein: a plurality of illuminating lamps (6) are fixed in the closed box (1), and the illuminating lamps (6) are electrically connected with the central controller (2).
5. The rat/mouse new environment feeding inhibition test device according to claim 1, wherein: the simulation straw mat (7) is laid on the top surface of the bottom plate of the closed box (1), and the sensor (3) and the food (4) are both located on the simulation straw mat (7).
6. The rat/mouse new environment feeding inhibition test device according to claim 1, wherein: a display screen (8) is fixed on the outer wall of the closed box (1), and the display screen (8) is electrically connected with the central controller (2).
7. The rat/mouse new environment feeding inhibition test device according to claim 1, wherein: the central controller (2) is further provided with a wireless communication module, and the central controller (2) is in communication connection with a mobile phone or a computer of an experimenter through the wireless communication module.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010946162.XA CN112262778B (en) | 2020-09-10 | 2020-09-10 | Feeding inhibition experimental device for rat/mouse new environment |
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| CN202010946162.XA CN112262778B (en) | 2020-09-10 | 2020-09-10 | Feeding inhibition experimental device for rat/mouse new environment |
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| CN112262778A CN112262778A (en) | 2021-01-26 |
| CN112262778B true CN112262778B (en) | 2022-11-22 |
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| CN113678748B (en) * | 2021-09-22 | 2022-11-04 | 山东中医药大学 | Intelligent carbohydrate water experimental system for rodent |
| CN114258864B (en) * | 2021-12-21 | 2023-03-24 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | Nerve engorgement experiment mouse instrument |
Citations (5)
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|---|---|---|---|---|
| DE102004059961A1 (en) * | 2004-12-13 | 2006-08-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Test cage for use in small mammal e.g. rat, behavior examining device, has detector device with emitter-detector-frame that surrounds inhabitation area and detects position and orientation of small mammals in inhabitation area |
| CN204047501U (en) * | 2014-08-15 | 2014-12-31 | 南华大学 | With static pressure wind chamber independent ventilation and can the animal rearing cage of convenient changing bedding and padding |
| CN109288529A (en) * | 2018-10-30 | 2019-02-01 | 南京医科大学 | A kind of animal Depressive behavior detection method and its detection device based on syrup preference |
| CN210168853U (en) * | 2019-05-21 | 2020-03-24 | 北京品安诺科技有限公司 | Groove type mousetrap |
| CN211153236U (en) * | 2019-11-15 | 2020-08-04 | 吉林农业科技学院 | Special raising box for laboratory mice |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004059961A1 (en) * | 2004-12-13 | 2006-08-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Test cage for use in small mammal e.g. rat, behavior examining device, has detector device with emitter-detector-frame that surrounds inhabitation area and detects position and orientation of small mammals in inhabitation area |
| CN204047501U (en) * | 2014-08-15 | 2014-12-31 | 南华大学 | With static pressure wind chamber independent ventilation and can the animal rearing cage of convenient changing bedding and padding |
| CN109288529A (en) * | 2018-10-30 | 2019-02-01 | 南京医科大学 | A kind of animal Depressive behavior detection method and its detection device based on syrup preference |
| CN210168853U (en) * | 2019-05-21 | 2020-03-24 | 北京品安诺科技有限公司 | Groove type mousetrap |
| CN211153236U (en) * | 2019-11-15 | 2020-08-04 | 吉林农业科技学院 | Special raising box for laboratory mice |
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