CN112244759A - OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel - Google Patents
OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel Download PDFInfo
- Publication number
- CN112244759A CN112244759A CN202011012588.4A CN202011012588A CN112244759A CN 112244759 A CN112244759 A CN 112244759A CN 202011012588 A CN202011012588 A CN 202011012588A CN 112244759 A CN112244759 A CN 112244759A
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- fiber coupler
- light
- reference arm
- schlemm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
Abstract
An OCT imaging system suitable for the whole-circumference dynamic measurement of a Schlemm's tube of a room corner outflow channel. The method is characterized in that: the light source can emit light to the first optical fiber coupler, the light is divided into sample arm light and reference arm light after passing through the first optical fiber coupler, the sample arm light enters the sample arm, the reference arm light enters the reference arm, the reference arm light is transmitted to the second optical fiber coupler after passing through the reference arm, and reflected light of the sample arm light and the reference arm light can be interfered in the third optical fiber coupler; the balance detector is connected with the third optical fiber coupler and the control center, and can extract signals and send the signals to the control center. The advantage lies in utilizing the reference arm structure of transmission-type, need not to use the circulator to avoid the narrow broadband restriction of circulator, remain axial resolution ratio to the utmost extent, thereby realize the observation and the measurement of Schlemm's pipe.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a swept frequency domain optical coherence tomography system and a swept frequency domain optical coherence tomography method for realizing high penetration and high resolution by a transmission-type reference arm and a circulator-free design, which are suitable for the full-cycle dynamic measurement of a Schlemm's tube of a room corner outflow channel.
Background
Glaucoma has become the second most blind eye disease worldwide after cataract, and is also the first irreversible blinding eye disease. The specific pathogenesis remains unclear, but it is now clear that elevated intraocular pressure (IOP) is the most important risk factor for the onset of glaucoma, while changes in the resistance of the aqueous outflow tract (primarily the trabecular meshwork outflow channel) are the major factors affecting IOP changes. Over 140 years of research, although a series of advances have been made, it has been revealed that the major resistance to aqueous humor outflow is in the Schlemm Canal (SC), also known as Schlemm canal, where aqueous humor enters the SC through the trabecular meshwork and then drains into the scleral veins through a collecting tube. SC are important pathways for aqueous humor to enter the circulatory system and also are important structures in the anterior chamber to maintain the blood-aqueous humor barrier. The resistance provided by this portion is 75-90% of the total outflow channel resistance. At present, the reasons for the resistance, such as the size of the lumen and the density of the pores, are theoretically revealed.
The existing detection and evaluation methods have certain limitations. In the early search for SC, due to the hidden SC position, small volume and the technical limitation, the study of trabecular meshwork and Schlemm's tube has been mainly in vitro means for a long time, including methods such as ordinary optical microscope (light microscope) and laser scanning confocal microscope. These methods can reflect well the ex vivo morphology of trabecular meshwork and Schlemm's tubes, but cannot reflect the in vivo function of trabecular meshwork and Schlemm's tubes. Methods for in vivo assessment currently include UBM and OCT. During UBM operation, the ultrasonic probe needs to contact an examination area, so that certain compression is exerted on an eyeball, slight form change of a Schlemm's tube can be caused, and certain limitation still exists. OCT is a novel imaging technology based on the principle of low coherence optical interference, has the characteristics of high resolution, non-contact, nondestructive detection and the like, and is widely applied to the field of medical imaging. The spectral domain OCT utilizes a spectrometer detection system to obtain interference spectral signals, and depth information is obtained by a Fourier transform method, so that the imaging speed and the imaging sensitivity are further improved. However, the existing OCT techniques are limited by factors such as scanning speed, penetration depth, resolution, etc., and only static measurement with local low resolution can be performed on OCT.
Disclosure of Invention
In order to overcome the defects of the background art, the invention provides an OCT imaging system suitable for the whole-circumference dynamic determination of a Schlemm's tube of an angle outflow channel.
The technical scheme adopted by the invention is as follows: an OCT imaging system suitable for the whole-cycle dynamic determination of a Schlemm's tube of a room corner outflow channel comprises a control center, a light source, a first optical fiber coupler, a sample arm, a reference arm, a second optical fiber coupler, a third optical fiber coupler and a balance detector;
the light source is used for outputting light;
the first optical fiber coupler is arranged corresponding to the light source, light rays are divided into sample arm light rays and reference arm light rays after passing through the first optical fiber coupler, the sample arm light rays enter the sample arm, and the reference arm light rays enter the reference arm;
the second optical fiber coupler is arranged corresponding to the reference arm, and the light of the reference arm passes through the reference arm and then is transmitted to the second optical fiber coupler;
the third optical fiber coupler is arranged corresponding to the first optical fiber coupler and the second optical fiber coupler, and reflected light of the sample arm light and reference arm light can interfere in the third optical fiber coupler;
the balance detector is connected with the third optical fiber coupler and the control center, and can extract signals and send the signals to the control center.
The light source is a sweep frequency source light source with the center wavelength of 1060nm and the broadband of 100nm, the sweep speed is 200kHz, and the light source is connected with the control center.
The reference arm comprises a first collimating mirror and a second collimating mirror, the first collimating mirror is arranged corresponding to the first optical fiber coupler, the second collimating mirror is arranged corresponding to the second optical fiber coupler, and light rays of the reference arm are received into the second optical fiber coupler by the second collimating mirror after being projected by the first collimating mirror.
The reference arm also includes a dispersion compensator.
The reference arm further comprises a first reflecting mirror and a second reflecting mirror, and the first reflecting mirror and the second reflecting mirror are symmetrically arranged.
The second optical fiber coupler is connected with a polarization controller.
The sample arm comprises a third collimating mirror, a first scanning galvanometer, a first lens, a second scanning galvanometer and a third lens, and light rays of the sample arm enter human eyes to be reflected after sequentially passing through the third collimating mirror, the first scanning galvanometer, the first lens, the second scanning galvanometer and the third lens.
The invention has the beneficial effects that: by adopting the scheme, the transmission-type reference arm structure is utilized, a circulator is not required, so that the narrow-broadband limitation of the circulator is avoided, the axial resolution is kept to the maximum extent, and the observation and measurement of the Schlemm's tube are realized.
Drawings
Fig. 1 is a schematic structural diagram of an OCT imaging system according to an embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a sample arm according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a reference arm according to an embodiment of the present invention.
Detailed Description
The embodiments of the invention will be further described with reference to the accompanying drawings in which:
as shown in the figure, the OCT imaging system suitable for the whole-cycle dynamic measurement of the Schlemm's canal of the angle of the room outflow channel comprises a control center 1, a light source 2, a first optical fiber coupler 3, a sample arm 4, a reference arm 5, a second optical fiber coupler 6, a third optical fiber coupler 7 and a balance detector 8.
The control center 1 is a computer and is used for controlling and analyzing and processing subsequent images.
The light source 2 is a frequency sweeping source light source with the central wavelength of 1060nm and the broadband of 100nm, the scanning speed is 200kHz, 1060nm can penetrate through pigment tissues of sclera and anterior segment of eye to reach a Schlemm's tube, the light source 2 is connected with the control center 1, light waves with different wavelengths can be periodically emitted in a short time under the control and feedback of the control center 1, the speed can reach hundreds of thousands of hertz and even higher, and the Schlemm tube can be rapidly and dynamically measured at different eye positions.
The first optical fiber coupler 3 is arranged in front of the light source 2, light is divided into sample arm light and reference arm light after passing through the first optical fiber coupler 3, the sample arm light enters the sample arm 4, and the reference arm light enters the reference arm 5.
The sample arm 4 comprises a third collimating mirror 41, a first scanning galvanometer 42, a first lens 43, a second lens 44, a second scanning galvanometer 45 and a third lens 46, and light rays of the sample arm sequentially pass through the third collimating mirror 41, the first scanning galvanometer 42, the first lens 43, the second lens 44, the second scanning galvanometer 45 and the third lens 46 and then enter human eyes to be reflected.
The first scanning galvanometer 42 and the second scanning galvanometer 45 can bend the light of the sample arm, the focal lengths of the first lens 43 and the second lens 44 are the same, so that 4F imaging of the scanning galvanometer is realized, optical distortion is reduced, and the third lens 46 is used for focal length adjustment, so that the focal length of the light of the sample arm can fall on a part required by imaging.
The reference arm 5 includes a first collimating mirror 51, a dispersion compensator 53, a first reflecting mirror 54, a second reflecting mirror 55 and a second collimating mirror 52 which are arranged in sequence, the first collimating mirror 51 is arranged corresponding to the first optical fiber coupler 3 and can receive reference arm light and project the reference arm light, the reference arm light projected by the first collimating mirror 51 compensates for the lens optical path of the corresponding sample arm region through the dispersion compensator 53, the first reflecting mirror 54 and the second reflecting mirror 55 are symmetrically arranged and can deflect the light reference arm, so that the occupied space is reduced, the second collimating mirror 52 is arranged corresponding to the second optical fiber coupler 6, and the reference arm light is received to the second optical fiber coupler 6 by the second collimating mirror 52 after passing through the first collimating mirror 51, the dispersion compensator 53, the first reflecting mirror 54 and the second reflecting mirror 55 in sequence.
The second optical fiber coupler 6 is used for optical path difference matching, and is selected according to the length requirement and the reflected light intensity requirement of the reference arm, so that the optical path difference matching of the sample arm and the reference arm is realized.
Further, the second optical fiber coupler 6 is connected with a polarization controller 9 for adjusting the polarization property of the light.
The third optical fiber coupler 7 is arranged corresponding to the first optical fiber coupler 3 and the second optical fiber coupler 6, and can receive the reflected light of the sample arm light and the reference arm light, wherein the reflected light of the sample arm light and the reference arm light can interfere with each other, and the third optical fiber coupler 7 preferably selects the light splitting efficiency specification of 50: 50.
The balance detector 8 is connected with the third optical fiber coupler 7 and the control center 1, can extract signals and send the signals to the control center 1, the balance detector 8 can eliminate common mode noise through subtraction of two optical input signals, changes in an optical signal path are reduced when the common mode noise is extracted from an interference noise background, and subsequent signal processing analysis is carried out through the control center 1.
The imaging process of the OCT imaging system suitable for the whole-cycle dynamic measurement of the angle outflow channel Schlemm's tube is as follows: the light source 2 emits light, the light is divided into two after passing through the first optical fiber coupler 3, one of the light is sample arm light, the sample arm light sequentially passes through the third collimating mirror 41, the first scanning galvanometer 42, the first lens 43, the second lens 44, the second scanning galvanometer 45 and the third lens 46 and then enters human eyes, the formed reflected light returns to the first optical fiber coupler 3 according to the original path and then enters the third optical fiber coupler 7, the other light is reference arm light, the reference arm light sequentially passes through the first collimating mirror 51, the dispersion compensator 53, the first reflecting mirror 54, the second reflecting mirror 55, the second collimating mirror 52 and the second optical fiber coupler 6 and then enters the third optical fiber coupler 7, in this case, the reflected light of the sample arm beam interferes with the reference arm beam, and the balanced detector 8 subsequently cancels the common-mode noise by subtracting the two optical input signals, reduces the change in the optical signal path when extracting from the interference noise floor and performs subsequent signal processing analysis by the control center 1.
By adopting the scheme, the transmission-type reference arm structure is utilized, a circulator is not required, so that the narrow-broadband limitation of the circulator is avoided, the axial resolution is kept to the maximum extent, and the observation and measurement of the Schlemm's tube are realized.
In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.
The skilled person should understand that: although the invention has been described in terms of the above specific embodiments, the inventive concept is not limited thereto and any modification applying the inventive concept is intended to be included within the scope of the patent claims.
Claims (7)
1. An OCT imaging system suitable for whole-circumference dynamic measurement of a Schlemm's tube of a room corner outflow channel is characterized in that: the device comprises a control center (1), a light source (2), a first optical fiber coupler (3), a sample arm (4), a reference arm (5), a second optical fiber coupler (6), a third optical fiber coupler (7) and a balance detector (8);
the light source (2) is used for outputting light;
the first optical fiber coupler (3) is arranged corresponding to the light source (2), light is divided into sample arm light and reference arm light after passing through the first optical fiber coupler (3), the sample arm light enters the sample arm (4), and the reference arm light enters the reference arm (5);
the second optical fiber coupler (6) is arranged corresponding to the reference arm (5), and the reference arm light passes through the reference arm (5) and then is transmitted to the second optical fiber coupler (6);
the third optical fiber coupler (7) is arranged corresponding to the first optical fiber coupler (3) and the second optical fiber coupler (6), and reflected light of sample arm light and reference arm light can interfere in the third optical fiber coupler (7);
and the balance detector (8) is connected with the third optical fiber coupler (7) and the control center (1), and can extract signals and send the signals to the control center (1).
2. The OCT imaging system of claim 1, adapted for use in whole-cycle dynamic determination of the angle of the house outflow tract of a Schlemm's canal, wherein: the light source (2) is a sweep frequency source light source with the center wavelength of 1060nm and the broadband of 100nm, the sweep speed is 200kHz, and the light source (2) is connected with the control center (1).
3. The OCT imaging system of claim 1, adapted for use in whole-cycle dynamic determination of the angle of the house outflow tract of a Schlemm's canal, wherein: the reference arm (5) comprises a first collimating mirror (51) and a second collimating mirror (52), the first collimating mirror (51) is arranged corresponding to the first optical fiber coupler (3), the second collimating mirror (52) is arranged corresponding to the second optical fiber coupler (6), and light rays of the reference arm are received into the second optical fiber coupler (6) by the second collimating mirror (52) after being projected out by the first collimating mirror (51).
4. The OCT imaging system of claim 3, adapted for use in whole-cycle dynamic determination of Schlemm's canal of the corner outflow tract, wherein: the reference arm (5) further comprises a dispersion compensator (53).
5. The OCT imaging system of claim 3 or 4, adapted for whole-cycle dynamics of Schlemm's canal of the angle of the house outflow tract, wherein: the reference arm (5) further comprises a first reflector (54) and a second reflector (55), and the first reflector (54) and the second reflector (55) are symmetrically arranged.
6. The OCT imaging system of claim 3, adapted for use in whole-cycle dynamic determination of Schlemm's canal of the corner outflow tract, wherein: the second optical fiber coupler (6) is connected with a polarization controller (9).
7. The OCT imaging system of claim 1, adapted for use in whole-cycle dynamic determination of the angle of the house outflow tract of a Schlemm's canal, wherein: the sample arm (4) comprises a third collimating mirror (41), a first scanning galvanometer (42), a first lens (43), a second lens (44), a second scanning galvanometer (45) and a third lens (46), and light rays of the sample arm enter human eyes to be reflected after sequentially passing through the third collimating mirror (41), the first scanning galvanometer (42), the first lens (43), the second lens (44), the second scanning galvanometer (45) and the third lens (46).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011012588.4A CN112244759A (en) | 2020-09-24 | 2020-09-24 | OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel |
| PCT/CN2020/124352 WO2022062050A1 (en) | 2020-09-24 | 2020-10-28 | Oct imaging system suitable for all-round dynamic determination of schlemm's canal of anterior chamber angle outflow channel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011012588.4A CN112244759A (en) | 2020-09-24 | 2020-09-24 | OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112244759A true CN112244759A (en) | 2021-01-22 |
Family
ID=74233043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011012588.4A Pending CN112244759A (en) | 2020-09-24 | 2020-09-24 | OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112244759A (en) |
| WO (1) | WO2022062050A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114869221B (en) * | 2022-05-23 | 2023-06-02 | 中国科学院苏州生物医学工程技术研究所 | Chromatic dispersion balanced sweep OCT fundus high-resolution imaging system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803908A (en) * | 2010-03-01 | 2010-08-18 | 浙江大学 | Dispersive modulation-based non-mirror image optimal frequency domain imaging system and method |
| WO2018049246A1 (en) * | 2016-09-08 | 2018-03-15 | Aleyegn Technologies Llc | Glaucoma treatment methods and apparatus |
| CN109157187A (en) * | 2018-09-06 | 2019-01-08 | 中国科学院上海光学精密机械研究所 | Increase the method for frequency sweep optical coherence tomography system imaging depth range |
| CN209074572U (en) * | 2018-05-10 | 2019-07-09 | 视微影像(河南)科技有限公司 | A kind of optical interference imaging system of frequency sweep OCT |
| CN209996294U (en) * | 2018-12-29 | 2020-01-31 | 佛山科学技术学院 | device for accurately measuring optical path difference between front and back surfaces of human cornea |
| CN111272708A (en) * | 2020-01-22 | 2020-06-12 | 深圳湾实验室 | OCT imaging system |
| US20200188173A1 (en) * | 2017-06-16 | 2020-06-18 | Michael S. Berlin | Methods and systems for oct guided glaucoma surgery |
| CN111671390A (en) * | 2020-05-25 | 2020-09-18 | 广东唯仁医疗科技有限公司 | Method for extracting pulse parameters of trabecular network |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565405B (en) * | 2013-11-15 | 2015-12-09 | 浙江大学 | Based on the spectral coverage OCT detection method of segmentation spectrum path encoding |
-
2020
- 2020-09-24 CN CN202011012588.4A patent/CN112244759A/en active Pending
- 2020-10-28 WO PCT/CN2020/124352 patent/WO2022062050A1/en active Application Filing
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803908A (en) * | 2010-03-01 | 2010-08-18 | 浙江大学 | Dispersive modulation-based non-mirror image optimal frequency domain imaging system and method |
| WO2018049246A1 (en) * | 2016-09-08 | 2018-03-15 | Aleyegn Technologies Llc | Glaucoma treatment methods and apparatus |
| US20200188173A1 (en) * | 2017-06-16 | 2020-06-18 | Michael S. Berlin | Methods and systems for oct guided glaucoma surgery |
| CN209074572U (en) * | 2018-05-10 | 2019-07-09 | 视微影像(河南)科技有限公司 | A kind of optical interference imaging system of frequency sweep OCT |
| CN109157187A (en) * | 2018-09-06 | 2019-01-08 | 中国科学院上海光学精密机械研究所 | Increase the method for frequency sweep optical coherence tomography system imaging depth range |
| CN209996294U (en) * | 2018-12-29 | 2020-01-31 | 佛山科学技术学院 | device for accurately measuring optical path difference between front and back surfaces of human cornea |
| CN111272708A (en) * | 2020-01-22 | 2020-06-12 | 深圳湾实验室 | OCT imaging system |
| CN111671390A (en) * | 2020-05-25 | 2020-09-18 | 广东唯仁医疗科技有限公司 | Method for extracting pulse parameters of trabecular network |
Non-Patent Citations (1)
| Title |
|---|
| 孙葆忱: "《临床低视力学》", 31 August 1989, 青岛出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022062050A1 (en) | 2022-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Aumann et al. | Optical coherence tomography (OCT): principle and technical realization | |
| Drexler et al. | State-of-the-art retinal optical coherence tomography | |
| JP6767762B2 (en) | Information processing device, control method of information processing device, and execution program of the control method | |
| US8797544B2 (en) | Optical coherence tomographic imaging device and imaging method of optical coherence tomographic image | |
| US11659992B2 (en) | Ophthalmic apparatus | |
| CN103491857B (en) | For improving the system and method for ophthalmology imaging | |
| JP6602671B2 (en) | Two-dimensional confocal imaging using OCT light source and scanning optics | |
| US20070038040A1 (en) | Arrangements, systems and methods capable of providing spectral-domain polarization-sensitive optical coherence tomography | |
| US8641193B2 (en) | Spectral contrast for glaucoma imaging | |
| JP6026406B2 (en) | Device for improving the image of the eye structure | |
| JP2013011625A (en) | Process, arrangements and systems for providing frequency domain imaging of sample | |
| US10337995B2 (en) | Systems and methods for oblique laser scanning | |
| CN103961061B (en) | Optical tomographic imaging apparatus and control method thereof | |
| CN101346104A (en) | Ophthalmological measuring system and method for determining the biometric data of an eye | |
| US9918628B2 (en) | Accommodation function evaluation apparatus | |
| CN103961062A (en) | Optical tomographic imaging apparatus and method for controlling the same | |
| WO2017178059A1 (en) | Automatic assessment of time-resolved oct images for selective retina therapy | |
| CN110013212B (en) | Multi-parameter and multi-functional eye measuring instrument based on optical coherence tomography | |
| CN112244759A (en) | OCT imaging system suitable for whole-cycle dynamic determination of Schlemm's tube of room corner outflow channel | |
| CN209285466U (en) | A kind of measuring device in body corneal parameters based on Optical Coherence Tomography Imaging Technology | |
| JP2020110224A (en) | Ophthalmologic device and control method thereof | |
| CN109171639A (en) | A kind of measuring device and measuring method in body corneal parameters based on Optical Coherence Tomography Imaging Technology | |
| CN109700426B (en) | Portable AO-OCT imaging device | |
| CN111281332A (en) | Multi-functional ophthalmic anterior segment imaging device based on slit lamp platform | |
| CN113017554A (en) | Imaging method and device for dynamic optical coherence tomography image of human eye corner position |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210122 |
|
| RJ01 | Rejection of invention patent application after publication |