CN112237679A - Left heart auxiliary device with heparin slow-release structure - Google Patents
Left heart auxiliary device with heparin slow-release structure Download PDFInfo
- Publication number
- CN112237679A CN112237679A CN202010967209.0A CN202010967209A CN112237679A CN 112237679 A CN112237679 A CN 112237679A CN 202010967209 A CN202010967209 A CN 202010967209A CN 112237679 A CN112237679 A CN 112237679A
- Authority
- CN
- China
- Prior art keywords
- heparin
- blood
- driving
- shaft seal
- left heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention belongs to the technical field of medical instruments, and particularly relates to a left heart auxiliary device with a heparin slow-release structure, which comprises a blood flow channel, an axial flow impeller and a driving device, wherein the driving device comprises a tubular shell and a driving assembly arranged in the tubular shell, one end of the tubular shell, which is close to a blood outflow port, is provided with a heparin shaft seal, and the heparin shaft seal comprises a polyurethane shell framework and a heparin inner core inside the polyurethane shell framework; compared with the prior art, the heparin shaft seal can not damage blood, and can avoid increasing blood circulation flow, increasing afterload and generating side effect on the recovery of cardiac function of a patient; in addition, the left-heart auxiliary device provided by the invention avoids punching on the motor body in the traditional scheme, namely the design and processing difficulty of the motor is reduced, and a normal saline water supply system of the left-heart auxiliary system is abandoned, so that the device is simpler.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a left heart auxiliary device with a heparin slow-release structure.
Background
For left heart failure patients, in case of ineffective medication, it is often necessary to provide a left heart assist device for purposes including: 1) waiting for the donor, preparing for heart transplantation; 2) the heart can be rested and the heart function can be recovered. The current left heart auxiliary device mainly comprises a temporary left heart auxiliary device and a long-term left heart auxiliary device; the temporary left heart auxiliary device comprises a partial axial flow pump and an air bag pulsating device and is mainly characterized by percutaneous puncture or incision and transvascular implantation; the advantages that the device can be implanted quickly, is relatively simple to drive, and is suitable for emergency rescue conditions of sudden cardiac failure; however, temporary left heart assist devices are not suitable for long term assistance, are placed in the neck or groin area, are only suitable for bedridden patients, require sedation during use, and are susceptible to infection at the transvascular delivery site. The long-term left heart auxiliary device comprises a pneumatic pump, a centrifugal pump and a partial axial flow pump, and is mainly characterized in that the device is placed in the chest by opening, a hole is formed in the apex of the left ventricle, the left ventricle blood is drained to enter the long-term left heart auxiliary device, and the pressurized blood is pumped into the aorta through an artificial blood vessel; the advantage lies in that the consumptive material is changed easily, and drive arrangement design is simple, but the shortcoming is also very obvious, and drive arrangement is comparatively huge, is unsuitable to be arranged in vivo, and exposes to the external pump body and the visual pump blood activity, causes harmful effects easily to patient's psychology to and, need pipe connection heart chamber and aorta, increased the energy consumption, and easily form the thrombus.
In the prior art, Impella is a commonly used temporary left heart assist device, which comprises a pigtail, a blood inflow port, a blood flow channel, a blood outflow port, an axial flow impeller, a driving motor and other components, wherein in the specific working process, the driving motor drives the axial flow impeller to rotate, so that blood is pumped from a left ventricle to an aorta, and the blood circulation of a patient is assisted. There is a bearing seal above the shaft of the driving motor, the purpose of the bearing seal is to prevent that when the axial impeller draws blood out, blood can enter the inside of the driving motor through the air gap of the bearing, thereby cause the short circuit of the driving motor and cause a series of bad accidents, and the existence of the bearing seal blocks the blood from flowing into the inside of the driving motor, but the blood ceaselessly strikes the bearing seal, thereby the blood cells receive huge impact force and produce stress response, secrete platelets, therefore the blood cells on the surface of the bearing can be gradually coagulated, finally form embolism, in case the embolism drops and enters the blood vessel and can block up direct less blood vessel, seriously affect the life safety of patients. Aiming at the problem, the scheme adopted by Impella is to add a shaft seal flushing system, namely, a plurality of holes of 0.9mm are arranged at the shaft seal position of a driving motor, a physiological saline supply device is externally connected with a pipeline to continuously flush the shaft seal position, the flushing amount is 240mL every 24 hours, and the pressure at the flushing position is up to 600 mmHg. The shaft seal flushing system described above presents significant drawbacks: firstly, the manufacturing difficulty of the driving motor is increased, the shaft seal flushing hole needs to be connected to external equipment through a pipeline to complete the flushing function, so that the hole needs to be punched through the driving motor, and the diameter of the hole is only 0.9mm, which brings great challenges to the processing and manufacturing of the driving motor; the other is that the shaft seal flushing system is equivalent to the continuous liquid injection into the blood circulation system of the patient, which increases the circulation flow and the afterload of the heart, which is extremely unfavorable for the recovery of the heart function of the heart failure patient.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides the left heart auxiliary device with the heparin slow-release structure, avoids the problem of embolism generated after the driving motor drives the axial flow impeller to pump blood out, and ensures the stability and reliability of the left heart auxiliary process.
In order to achieve the purpose, the invention adopts the following technical scheme:
a left heart assist device with a heparin release structure, comprising:
a blood flow channel having a blood inflow port and a blood outflow port;
the axial flow impeller is rotationally connected inside the blood flow channel; and
the driving device is positioned outside the blood outflow port and used for driving the axial-flow impeller to rotate and impel the blood in the blood flow channel to flow;
the driving device comprises a tubular shell and a driving assembly arranged in the tubular shell, wherein one end of the tubular shell, which is close to the blood outflow port, is provided with a heparin shaft seal, and the heparin shaft seal comprises a polyurethane shell framework and a heparin inner core inside the polyurethane shell framework.
Preferably, the polyurethane shell skeleton is provided with a plurality of diffusion holes which are arranged at intervals along the circumferential direction of the polyurethane shell skeleton.
Preferably, the diffusion holes are nano-scale micropores, and the pore diameter of the diffusion holes is 3 nm.
Preferably, the driving device includes a driving motor and a controller, the driving motor is used for driving the axial-flow impeller to rotate, and the controller is connected with the driving motor and is used for adjusting the output power of the driving motor.
Compared with the prior art, the invention has the following technical effects:
compared with the prior art, the technical scheme has the advantages that the blood is prevented from being damaged, the blood circulation flow is prevented from being increased, afterload is prevented from being increased, and side effects on the recovery of the cardiac function of a patient are avoided;
in addition, the left-heart auxiliary device provided by the invention avoids punching on the motor body in the traditional scheme, namely the design and processing difficulty of the motor is reduced, and a normal saline water supply system of the left-heart auxiliary system is abandoned, so that the device is simpler.
Additional features and advantages of the invention will be set forth in the detailed description which follows.
Drawings
FIG. 1 is a schematic structural diagram of a left heart assist device with a heparin sustained-release structure according to an embodiment of the invention;
FIG. 2 is an exploded view of a drive device according to an embodiment of the present invention;
FIG. 3 is a schematic view of a heparin shaft seal according to an embodiment of the present invention;
the reference numbers in the figures illustrate: 10-blood flow channel, 11-blood inflow port, 12-blood outflow port, 20-driving device, 21-tubular shell, 30-heparin shaft seal and 31-diffusion hole.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further clarified by combining the specific drawings.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1-3, the present invention provides a left heart assist device with a heparin release structure, comprising a blood channel 10, an axial flow impeller (not shown in the figure) and a driving device 20, wherein the blood channel 10 has a blood inflow port 11 and a blood outflow port 12, and the axial flow impeller is rotatably connected inside the blood channel 10; the driving device 20 is located outside the blood outflow port 12 and is used for driving the axial-flow impeller to rotate and impel the blood in the blood flow channel 10 to flow; the driving device 20 includes a tubular housing 21 and a driving assembly disposed in the tubular housing 21, wherein a heparin shaft seal 30 is disposed at one end of the tubular housing 21 adjacent to the blood outflow port 12, and the heparin shaft seal 30 includes a polyurethane outer shell frame and a heparin core therein.
When the left heart auxiliary device provided by the invention is used, the device is implanted through the femoral artery of a human body in a minimally invasive way, the device ascends and crosses the aortic arch, finally, the blood inflow port 11 enters the left ventricle, the blood outflow port 12 is positioned in the aorta, and after the blood pump works, blood deposited in the left ventricle can be pumped out and sent into the aorta. In the specific working process, the heparin shaft seal 30 can release heparin at a certain speed, so that the effect of preventing blood from coagulating is achieved, and blood cannot be damaged; and, based on the heparin shaft seal provided by the present invention, the blood circulation flow rate is not increased, the afterload is not increased, and there is no side effect on the recovery of the cardiac function of the patient. In addition, according to the technical scheme provided by the invention, the traditional scheme that holes are formed in the motor body is avoided, the design and processing difficulty of the motor is reduced, and a physiological saline water supply system of a left-heart auxiliary system is abandoned, so that the device is simpler.
Further, according to the present invention, the polyurethane shell skeleton is provided with a plurality of diffusion holes 31 arranged along the circumferential direction at intervals. Furthermore, the diffusion holes 31 are nano-scale micropores, and the pore diameter is 3 nm.
Further, according to the present invention, the driving device 20 includes a driving motor for driving the axial-flow impeller to rotate, and a controller connected to the driving motor for adjusting the output power of the driving motor.
In the technical scheme provided by the invention, the heparin inner core is dissolved and seeps out through the nano-scale micropores to achieve the effect of preventing blood from coagulating at the shaft seal, wherein the dissolution and release of the heparin inner core depend on the size of the diffusion hole and the size of blood flow, the diffusion hole is directly large, the blood flow is large, the slow release speed is higher, otherwise, the slow release speed is smaller, and the content of the heparin inner core can support the working time of the left heart auxiliary device for 14 days at most.
The foregoing shows and describes the general principles, essential features, and inventive features of this invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (4)
1. The utility model provides a left heart auxiliary device with heparin slow-release structure which characterized in that includes:
a blood flow channel having a blood inflow port and a blood outflow port;
the axial flow impeller is rotationally connected inside the blood flow channel; and
the driving device is positioned outside the blood outflow port and used for driving the axial-flow impeller to rotate and impel the blood in the blood flow channel to flow;
the driving device comprises a tubular shell and a driving assembly arranged in the tubular shell, wherein one end of the tubular shell, which is close to the blood outflow port, is provided with a heparin shaft seal, and the heparin shaft seal comprises a polyurethane shell framework and a heparin inner core inside the polyurethane shell framework.
2. The left heart auxiliary device with the heparin releasing structure as claimed in claim 1, wherein the polyurethane shell skeleton is provided with a plurality of diffusion holes arranged at intervals along the circumference thereof.
3. The left heart auxiliary device with heparin releasing structure as claimed in claim 2, wherein said diffusion hole is nano-scale micro-hole with a pore size of 3 nm.
4. The left heart assist device with heparin releasing structure as claimed in claim 1, wherein said driving device comprises a driving motor and a controller, said driving motor is used to drive said axial flow impeller to rotate, said controller is connected to said driving motor for adjusting the output power of said driving motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010967209.0A CN112237679A (en) | 2020-09-15 | 2020-09-15 | Left heart auxiliary device with heparin slow-release structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010967209.0A CN112237679A (en) | 2020-09-15 | 2020-09-15 | Left heart auxiliary device with heparin slow-release structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112237679A true CN112237679A (en) | 2021-01-19 |
Family
ID=74171341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010967209.0A Pending CN112237679A (en) | 2020-09-15 | 2020-09-15 | Left heart auxiliary device with heparin slow-release structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112237679A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115837118A (en) * | 2022-11-01 | 2023-03-24 | 北京航空航天大学 | Centrifugal blood pump driven by magnetic coupling |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07178165A (en) * | 1993-12-24 | 1995-07-18 | San Medical Gijutsu Kenkyusho:Kk | Sealing mechanism for artificial heart |
| EP0768091A1 (en) * | 1995-10-16 | 1997-04-16 | Sun Medical Technology Research Corporation | Artificial heart |
| JP2000237304A (en) * | 1999-02-23 | 2000-09-05 | Nikkiso Co Ltd | Blood pump |
| CN202236531U (en) * | 2010-03-12 | 2012-05-30 | 缪新元 | Blood pump capable of driving rotating body by motor through shaft |
| CN105641762A (en) * | 2016-03-14 | 2016-06-08 | 正仁（北京）医疗仪器有限公司 | In-vitro non-implantable maglev heart chamber assisting centrifugal blood pump |
-
2020
- 2020-09-15 CN CN202010967209.0A patent/CN112237679A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07178165A (en) * | 1993-12-24 | 1995-07-18 | San Medical Gijutsu Kenkyusho:Kk | Sealing mechanism for artificial heart |
| EP0768091A1 (en) * | 1995-10-16 | 1997-04-16 | Sun Medical Technology Research Corporation | Artificial heart |
| JP2000237304A (en) * | 1999-02-23 | 2000-09-05 | Nikkiso Co Ltd | Blood pump |
| CN202236531U (en) * | 2010-03-12 | 2012-05-30 | 缪新元 | Blood pump capable of driving rotating body by motor through shaft |
| CN105641762A (en) * | 2016-03-14 | 2016-06-08 | 正仁（北京）医疗仪器有限公司 | In-vitro non-implantable maglev heart chamber assisting centrifugal blood pump |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115837118A (en) * | 2022-11-01 | 2023-03-24 | 北京航空航天大学 | Centrifugal blood pump driven by magnetic coupling |
| CN115837118B (en) * | 2022-11-01 | 2023-07-04 | 北京航空航天大学 | Magnetic coupling driven centrifugal blood pump |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9504774B2 (en) | Intraatrial ventricular assist device | |
| AU2016253685B2 (en) | Methods and apparatus for active or passive assistance in the circulatory system | |
| AU2015200914B2 (en) | Methods and apparatus for active or passive assistance in the circulatory system | |
| Reul et al. | Blood pumps for circulatory support | |
| JP4532256B2 (en) | Implantable cardiac assist device | |
| US4625712A (en) | High-capacity intravascular blood pump utilizing percutaneous access | |
| JP2830440B2 (en) | Cannula | |
| US10814053B2 (en) | Dual-pump continuous-flow total artificial heart | |
| US9981078B2 (en) | Left ventricular assist device | |
| JPH08504621A (en) | Temporary cardiac support cannula pump | |
| CN105498002A (en) | Blood pumping impeller | |
| CN204147329U (en) | A kind of left ventricular assist device | |
| CN112237679A (en) | Left heart auxiliary device with heparin slow-release structure | |
| CN104174078A (en) | Left ventricle auxiliary device | |
| CN112237680A (en) | Axial-flow type heart auxiliary device with heparin coating and hydrophobic protection | |
| JPH04176471A (en) | Circulation auxiliary pump | |
| CN219804146U (en) | External magnetic suspension centrifugal ventricular assist device implanted through periphery | |
| US20120035645A1 (en) | Dynamic and static blood filters | |
| US20230201561A1 (en) | Re-sealable member of distal bearing support | |
| CN216136569U (en) | Aorta internal circulation auxiliary blood pump rotor | |
| US20220152362A1 (en) | Intravascular gas exchange device and method | |
| WO2023278351A1 (en) | Axial flow pumps for supporting cardiac function | |
| CN116077821A (en) | Pressure-driven heart auxiliary device | |
| Wnek et al. | Cardiac Assist Devices/Keefe B. Manning, Conrad M. Zapanta, John M. Tarbell |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |