CN112237246A - Preparation method of solid beverage capable of being directly taken orally - Google Patents
Preparation method of solid beverage capable of being directly taken orally Download PDFInfo
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- CN112237246A CN112237246A CN202011118007.5A CN202011118007A CN112237246A CN 112237246 A CN112237246 A CN 112237246A CN 202011118007 A CN202011118007 A CN 202011118007A CN 112237246 A CN112237246 A CN 112237246A
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 24
- 239000007787 solid Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title abstract description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000000243 solution Substances 0.000 claims abstract description 34
- 238000001704 evaporation Methods 0.000 claims abstract description 33
- 150000002632 lipids Chemical class 0.000 claims abstract description 29
- 238000000227 grinding Methods 0.000 claims abstract description 23
- 239000007864 aqueous solution Substances 0.000 claims abstract description 22
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 22
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 238000009210 therapy by ultrasound Methods 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims abstract description 12
- 239000004386 Erythritol Substances 0.000 claims abstract description 11
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims abstract description 11
- 240000001717 Vaccinium macrocarpon Species 0.000 claims abstract description 11
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims abstract description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 11
- 235000004634 cranberry Nutrition 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 235000019414 erythritol Nutrition 0.000 claims abstract description 11
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 11
- 229940009714 erythritol Drugs 0.000 claims abstract description 11
- 230000003301 hydrolyzing effect Effects 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 11
- 239000000811 xylitol Substances 0.000 claims abstract description 11
- 235000010447 xylitol Nutrition 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 11
- 229960002675 xylitol Drugs 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 13
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- 238000007710 freezing Methods 0.000 claims description 10
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- 238000004806 packaging method and process Methods 0.000 claims description 10
- 239000003223 protective agent Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 abstract description 8
- 210000004877 mucosa Anatomy 0.000 abstract description 6
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- 238000005538 encapsulation Methods 0.000 description 5
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- 102000035195 Peptidases Human genes 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a preparation method of a solid beverage capable of being directly taken orally, which comprises the following steps; s1, hydrolyzing a mixture of 20-30 parts by weight of xylitol, 25-35 parts by weight of erythritol and 30-40 parts by weight of cranberry powder to prepare an aqueous solution for later use; s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment; s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle; s4, adding 20mL of ether to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S; s5, continuing to carry out ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in the constant-temperature water bath at 35 ℃ for 60min to 100 min. The product can penetrate intercellular lipid particles of buccal mucosa and sublingual mucosa of the oral cavity through a nanometer lipid carrier technology and an airflow type superfine grinding technology, and can directly flow back to enter systemic circulation through capillaries and veins after penetrating the mucosa.
Description
Technical Field
The invention relates to the technical field of food, in particular to a preparation method of a solid beverage capable of being directly taken orally.
Background
At present, solid beverage products on the market are all taken in a way of being dissolved in water and then being digested and absorbed by gastrointestinal tracts. The method has many defects, such as inconvenient taking, loss of nutritional ingredients of the product caused by brewing temperature, stimulation to gastrointestinal tract after taking, degradation and inactivation of the product when passing through the gastrointestinal tract, poor absorption effect of the nutritional ingredients, incapability of highly utilizing the effective ingredients and the like.
Researches find that the oral mucosa has a mild environment, abundant blood flow under the mucosa, no first-pass effect in mucosal absorption and other absorption advantages, but the oral mucosa has a penetration barrier to cause absorption obstacle. Lipid particles + particles are present in the granular layer intercellular space of the oral epithelium, which are excreted by the membrane particles, and this granular layer makes the biological substances impermeable to the epithelial cells.
Based on the above, the invention provides a preparation method of a solid beverage capable of being directly orally taken.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a preparation method of a solid beverage capable of being directly taken orally.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method for preparing solid beverage for direct oral administration comprises the following steps;
s1, hydrolyzing a mixture of 20-30 parts by weight of xylitol, 25-35 parts by weight of erythritol and 30-40 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 60-100 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
Preferably, in the step S2, the ratio of the mixture to the phospholipid is 3: 5.
Preferably, in the steps S3 and S5, the rotation speed of the thermostatic waterbath is 60 r/min.
Preferably, in the step S8, the weight of the product package is 2 g/bag.
Preferably, the method for preparing the solid beverage capable of being directly orally taken comprises the following steps;
s1, hydrolyzing a mixture of 20 parts by weight of xylitol, 25 parts by weight of erythritol and 30 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution for 60min in a constant-temperature water bath at 35 ℃;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
Preferably, the method for preparing the solid beverage capable of being directly orally taken comprises the following steps;
s1, hydrolyzing a mixture of 25 parts by weight of xylitol, 30 parts by weight of erythritol and 35 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 80 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
The invention has the following beneficial effects:
1. the product adopts a reverse evaporation method to prepare the nano lipid carrier, and the encapsulation rate can reach 98 percent. The product has higher stability, and can not be degraded due to the hydrolysis effect of proteolytic enzyme in the oral cavity and the saliva washing effect;
2. the product can penetrate through intercellular lipid particles of buccal mucosa and sublingual mucosa of the oral cavity with the assistance of the carrier, and reaches the absorption of capillary vessels, the absorption effect is improved by 50 percent compared with gastrointestinal absorption, and the product has higher absorption rate;
3. firstly, the average particle size of the prepared nano lipid carrier is about 50-1000nm, and then the product is crushed to 10-25 microns by the airflow type superfine crushing technology, so that the specific surface area of the product is increased, the micropowder is easier to adsorb oral mucosa due to small particle size, the adhesion time is prolonged, and the absorption is promoted;
4. after superfine grinding, the insoluble cellulose is changed into soluble dietary fiber, so that edible food resources are increased, and the nutrition is comprehensively absorbed;
5. the nutritional ingredients are directly absorbed by the oral cavity, the heat is taken away, and the good taste sensation of comfort, coolness and quickness is brought to people, so that the taste of people is fresh and cool.
Drawings
FIG. 1 is a schematic flow chart of the steps of a method for preparing a solid beverage capable of being directly orally taken according to the present invention.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed as broadly as the present invention is capable of modification in various respects, all without departing from the spirit and scope of the present invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1, a method for preparing a solid beverage for direct oral administration includes the following steps;
s1, hydrolyzing a mixture of 20-30 parts by weight of xylitol, 25-35 parts by weight of erythritol and 30-40 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 60-100 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
In step S2, the ratio of mixture to phospholipids is 3: 5.
In steps S3 and S5, the rotation speed of the thermostatic waterbath is 60 r/min.
In step S8, the weight of the product package is 2 g/bag.
By the nanometer lipid carrier technology and the airflow type superfine grinding technology, the product can penetrate through intercellular lipid particles of buccal mucosa and sublingual mucosa of the oral cavity, and can directly flow back to the systemic circulation through capillaries and veins after penetrating through the mucosa.
In order to better examine the encapsulation efficiency, absorption rate and adhesion time of the solid beverage of the present invention for preparing a direct oral solid beverage, the present invention was tested by way of specific examples below.
Example one
S1, hydrolyzing a mixture of 20 parts by weight of xylitol, 25 parts by weight of erythritol and 30 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution for 60min in a constant-temperature water bath at 35 ℃;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
Example two
S1, hydrolyzing a mixture of 25 parts by weight of xylitol, 30 parts by weight of erythritol and 35 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 80 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
EXAMPLE III
S1, hydrolyzing a mixture of 30 parts by weight of xylitol, 35 parts by weight of erythritol and 40 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 100 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
In the above-mentioned process for preparing a solid beverage for direct oral administration, the encapsulation efficiency, absorption rate and adhesion time of the solid beverage for direct oral administration are as follows:
| using this protocol to prepare | Encapsulation efficiency | Absorption rate | Adhesion time |
| Example one | 93% | 93% | 10s |
| Example two | 98% | 97% | 20s |
| EXAMPLE III | 96% | 95% | 15s |
The experimental data show that the solid beverage prepared by the second embodiment and capable of being directly orally taken has excellent encapsulation efficiency, absorption rate and adhesion time, so that the solid beverage capable of being directly orally taken has a wide application range, strong practicability and good application prospect.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. A method for preparing solid beverage for direct oral administration comprises the following steps;
s1, hydrolyzing a mixture of 20-30 parts by weight of xylitol, 25-35 parts by weight of erythritol and 30-40 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 60-100 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
2. The method of claim 1, wherein the ratio of the mixture to the phospholipid in step S2 is 3: 5.
3. The method for preparing a solid beverage for direct oral administration according to claim 1, wherein the rotation speed of the thermostatic waterbath in steps S3 and S5 is 60 r/min.
4. A method for preparing a solid beverage for direct oral administration according to claim 1, wherein the weight of the product package is 2 g/bag in the step S8.
5. The method for preparing a solid beverage for direct oral administration according to claim 1, wherein the method for preparing a solid beverage for direct oral administration comprises the steps of;
s1, hydrolyzing a mixture of 20 parts by weight of xylitol, 25 parts by weight of erythritol and 30 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution for 60min in a constant-temperature water bath at 35 ℃;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
6. A method of preparing a solid beverage for direct oral administration according to claim 1, comprising the steps of;
s1, hydrolyzing a mixture of 25 parts by weight of xylitol, 30 parts by weight of erythritol and 35 parts by weight of cranberry powder to prepare an aqueous solution for later use;
s2, mixing phospholipid and cholesterol according to the ratio of 5: dissolving 1 in 20mL of diethyl ether in a weight ratio, adding a mixed material aqueous solution, and carrying out ultrasonic treatment;
s3, rotationally evaporating the ultrasonic-treated water solution in a constant-temperature water bath at 35 ℃ to precipitate a dried lipid membrane on the wall of the bottle;
s4, adding 20mL of ether into the bottle to dissolve the dry film, adding 10mL of triple distilled water, and uniformly mixing on an oscillator for 30S;
s5, continuing to perform ultrasonic treatment on the solution for 6min, and then rotationally evaporating the solution in a constant-temperature water bath at 35 ℃ for 80 min;
s6, adding a freeze-drying protective agent into the bottle after evaporation and drying, freezing and continuously drying to obtain a nano lipid carrier containing the effective components of the product;
s7, putting the product into airflow type superfine grinding equipment, and grinding the product to 10-25 microns under the action of airflow;
and S8, packaging the crushed product and warehousing.
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