CN112229947B - Method for measuring residual oxygen amount of gas in ampoule bottle - Google Patents
Method for measuring residual oxygen amount of gas in ampoule bottle Download PDFInfo
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- CN112229947B CN112229947B CN202010880978.7A CN202010880978A CN112229947B CN 112229947 B CN112229947 B CN 112229947B CN 202010880978 A CN202010880978 A CN 202010880978A CN 112229947 B CN112229947 B CN 112229947B
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- 239000007789 gas Substances 0.000 title claims abstract description 132
- 239000003708 ampul Substances 0.000 title claims abstract description 45
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000001301 oxygen Substances 0.000 title claims abstract description 35
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 49
- 238000007789 sealing Methods 0.000 claims abstract description 11
- 239000004033 plastic Substances 0.000 claims description 4
- 239000012780 transparent material Substances 0.000 claims description 4
- 238000012827 research and development Methods 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 abstract description 2
- 238000001514 detection method Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 125000003003 spiro group Chemical group 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000005491 wire drawing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Combustion & Propulsion (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The invention provides a method for measuring the residual oxygen amount of gas in an ampoule bottle, and belongs to the technical field of residual oxygen amount measurement of gas in ampoule bottles. The method comprises the following steps: filling water with a preset height in a water tank, and completely immersing a gas collecting bottle with one end being a sealing end and the other end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealed end of the gas collecting bottle faces upwards; slowly moving the gas collecting bottle upwards to enable the sealing end of the gas collecting bottle to be arranged outside the water surface, the opening end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealing end of the gas collecting bottle and the water surface; a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity; placing the ampoule bottle below the water surface and in the opening end of the gas collecting bottle; and breaking the ampoule bottle, discharging the gas in the ampoule bottle into the gas collection cavity, and detecting the gas in the gas collection cavity by using a residual oxygen detector. The invention can accurately measure the residual oxygen amount of the gas in the ampoule bottle and provide data support for product research and development.
Description
Technical Field
The invention belongs to the technical field of measurement of residual oxygen content of gas in an ampoule bottle, and particularly relates to a method for measuring residual oxygen content of gas in the ampoule bottle.
Background
A part of space inside the ampoule product is not filled with liquid medicine and contains oxygen, and the liquid medicine can react with the oxygen, particularly high-grade medicines are sensitive to the oxygen and are extremely easy to react with the oxygen, so that the curative effect and the storage period of the medicines are influenced.
Although protective nitrogen is filled before filling and wire drawing through a series of means, the proportion of the residual oxygen in the upper air of the product is not easy to detect, no data support is provided for product research and development, the actual oxygen content percentage of the product must be known, and a measurement method needs to be found.
Disclosure of Invention
The invention provides a method for measuring residual oxygen in ampoule bottle, which aims to solve the technical problem in the background technology.
The invention adopts the following technical scheme:
a method for measuring the residual oxygen content of gas in an ampoule bottle comprises the following steps:
filling water with a preset height in the water tank, and completely immersing a gas collecting bottle with one end being a sealing end and one end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealed end of the gas collecting bottle faces upwards;
slowly moving the gas collecting bottle upwards to enable the sealed end of the gas collecting bottle to be arranged outside the water surface, the open end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealed end of the gas collecting bottle and the water surface;
a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity;
placing the ampoule bottle below the water surface and in the opening end of the gas collecting bottle;
and breaking the ampoule bottle to discharge the gas in the ampoule bottle into the gas collection cavity, and detecting the gas in the gas collection cavity by using a residual oxygen detector.
Furthermore, the gas collecting bottle is a plastic bottle made of transparent materials.
Further, the sealed end of gas collecting bottle comprises first rubber buffer.
Further, the gas collecting bottle still includes the bottom, the bottom spiro union is at the open end of gas collecting bottle, just the middle part of bottom is equipped with the second rubber buffer, it has the cross mouth to draw on the second rubber buffer, be close to on the lateral wall of gas collecting bottle the breach has been seted up in the position of open end, be provided with the third rubber buffer in the breach, it has the cross mouth to draw on the third rubber buffer.
Compared with the prior art, the invention has the beneficial effects that:
the method provided by the invention can accurately measure the residual oxygen amount of the gas in the ampoule bottle, provides data support for product research and development, and provides an optimization basis for a process during production. Meanwhile, the method has low cost and simple and convenient operation.
Drawings
FIG. 1 is a schematic diagram of a system for measuring the residual oxygen content in an ampoule according to example 1 of the present invention;
fig. 2 is a schematic diagram of a gas collection bottle of a system required by the method for measuring the residual oxygen content of gas in an ampoule bottle in example 1 provided by the invention.
Fig. 3 is a schematic view of the bottom cap of the system for measuring the residual oxygen content in ampoule bottle according to the method of example 1.
Illustration of the drawings: 1-a water tank, 2-water, 3-a gas collection bottle, 4-a sealed end, 5-an open end, 6-a gas collection cavity, 7-an ampoule bottle, 8-a bottom cover, 9-a second rubber plug, 10-a cross port and 11-a third rubber plug.
Detailed Description
The present invention will be further described with reference to the following examples, which are intended to illustrate only some, but not all, of the embodiments of the present invention. Based on the embodiments of the present invention, other embodiments used by those skilled in the art without any creative effort belong to the protection scope of the present invention.
Example 1:
as shown in fig. 1, a method for measuring residual oxygen in ampoule bottle 7 includes the following steps:
s100: filling water 2 with a preset height in a water tank 1, and completely immersing a gas collecting bottle 3 with a sealed end 4 at one end and an open end 5 at the other end in the water 2; after the gas collecting bottle 3 is filled with water 2, turning over the gas collecting bottle 3 in the water 2 to enable the sealing end 4 of the gas collecting bottle 3 to face upwards;
in this step, the water 2 with a predetermined height is typically 80% of the water 2 pre-filled in the water tank 1, and the water 2 fills the gas-collecting bottle 3 from the opening end 5 in order to exhaust the gas inside the gas-collecting bottle 3.
S200: slowly moving the gas collecting bottle 3 upwards to enable the sealed end 4 of the gas collecting bottle 3 to be arranged outside the water 2 surface, the open end 5 of the gas collecting bottle 3 to be arranged below the water 2 surface, and forming a gas collecting cavity 6 between the sealed end 4 of the gas collecting bottle 3 and the water 2 surface; at this time, the gas collecting chamber 6 is free of any gas.
The gas collection bottle 3 is preferably a plastic bottle made of transparent material, and the sealing end 4 of the gas collection bottle 3 is made of a first rubber plug, so that a rubber plug is selected to facilitate the insertion of the needle of the residual oxygen detector into the gas collection chamber 6 through the sealing of the rubber plug, so as to facilitate the detection of the gas in the ampoule bottle 7 collected in the gas collection chamber 6.
Meanwhile, the transparent material is also used for facilitating an operator to watch the liquid level in the gas collecting cavity 6.
S300: the needle head of the residual oxygen detector is hermetically inserted into the gas collection cavity 6;
the model of the adopted residual oxygen detector is OXYBABY 6io2.
S400: placing the ampoule bottle 7 below the water 2 and in the opening end 5 of the gas collecting bottle 3;
in this step, in order to prevent the gas in the ampoule bottle 7 from escaping to the outside of the gas collecting bottle 3 after the ampoule bottle 7 is broken, the ampoule bottle 7 is placed inside the opening end 5 of the gas collecting bottle 3 as much as possible, and when the ampoule bottle 7 is broken, the above operations all need to be performed with a small amplitude by means of tools such as tweezers, so as to prevent other gases from entering the gas collecting cavity 6 of the gas collecting bottle 3 and interfering with the test result.
S500: and breaking the ampoule bottle 7, discharging the gas in the ampoule bottle 7 into the gas collection cavity 6, and detecting the gas in the gas collection cavity 6 by using a residual oxygen detector.
In the case of the 1 ml ampoule bottle 7, the gas is not easily discharged, and the gas is discharged by lightly tapping several times with a finger. After the gas in one ampoule bottle 7 is exhausted, the second ampoule bottle 7 is broken off until enough gas is in the gas collecting cavity 6 at the upper part of the gas collecting bottle 3 and can be detected for more than two times, the gas collecting bottle 3 is kept in the water 2 all the time, the gas above the plastic bottle is detected by using a residual oxygen meter, the oxygen content of the part of gas is measured, the detection can be performed for two times, whether the residual oxygen values are consistent or not is judged, the difference is very small actually, and the detection is basically an average value.
Example 2
As shown in fig. 1-3, the method of measuring residual oxygen content in gas in ampoule 7 that this embodiment provided, the same part with embodiment 1 is no longer repeated, and the difference lies in, in this embodiment, gas collecting bottle 3 still includes bottom 8, 8 spiro couplings of bottom are at gas collecting bottle 3's open end 5, just bottom 8's middle part is equipped with second rubber buffer 9, it has cross mouth 10 to mark on the second rubber buffer 9, be close to on gas collecting bottle 3's the lateral wall set up jaggedly in open end 5's the position, be provided with third rubber buffer 11 in the breach, it has cross mouth 10 to mark on third rubber buffer 11.
In this embodiment, add bottom 8, when the ampoule 7 is broken, ensure that gas is all collected in gas collecting chamber 6, further improve the accuracy of detecting. In order to achieve the purpose, a cross-shaped opening 10 is marked on the second rubber plug 9, and a cross-shaped opening 10 is marked on the third rubber plug 11, so that in the process of turning over and slowly moving up the gas collection bottle 3 under the water 2 to form the gas collection chamber 6, the bottom cover 8 is not installed, when the sealed end 4 of the gas collection bottle 3 is placed out of the water 2 and the open end 5 of the gas collection bottle 3 is placed under the water 2, the position of the gas collection bottle 3 is kept, the bottom cover 8 is installed and turned on at the open end 5 of the gas collection bottle 3 under the water 2, then the ampoule bottle 7 is deeply inserted into the gas collection bottle 3 through the cross-shaped opening 10 marked on the second rubber plug 9, then a tool for opening the ampoule bottle 7 is used, for example, tweezers are deeply inserted into the gas collection bottle 3 through the cross-shaped opening 10 marked on the third rubber plug 11, the ampoule bottle 7 is broken and opened, so that the gas in the ampoule bottle is released and escapes into the gas collection chamber 6, and the detection is completed.
This embodiment is through making further optimization and improvement to gas-collecting bottle 3 for gas-collecting chamber 6 is more accurate when gathering the gas in ampoule 7, is favorable to improving the detection precision.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (3)
1. The method for measuring the residual oxygen content of gas in the ampoule bottle is characterized by comprising a gas collection bottle with one sealed end and one open end, and a bottom cover, wherein the bottom cover is screwed at the open end of the gas collection bottle, a second rubber plug is arranged in the middle of the bottom cover, a cross port is arranged on the second rubber plug, a notch is formed in the position, close to the open end, of the side wall of the gas collection bottle, a third rubber plug is arranged in the notch, and a cross port is arranged on the third rubber plug;
the method comprises the following steps:
filling water with a preset height in the water tank, and completely immersing a gas collecting bottle with one end being a sealing end and one end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealed end of the gas collecting bottle faces upwards;
slowly moving the gas collecting bottle upwards to enable the sealing end of the gas collecting bottle to be arranged outside the water surface, the opening end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealing end of the gas collecting bottle and the water surface; in the process of turning over the gas collecting bottle underwater and slowly moving upwards to form a gas collecting cavity, the bottom cover is not installed, when the sealing end of the gas collecting bottle is arranged outside the water surface and the opening end of the gas collecting bottle is arranged under the water surface, the position of the gas collecting bottle is kept, and the bottom cover is installed on the opening end of the gas collecting bottle through a knob under the water;
the ampoule bottle extends into the gas collection bottle through the cross-shaped opening formed in the second rubber plug, then a tool for opening the ampoule bottle extends into the gas collection bottle through the cross-shaped opening formed in the third rubber plug to complete breaking and opening of the ampoule bottle, so that gas in the ampoule bottle is released and escapes into the gas collection cavity;
a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity; and detecting the gas in the gas collection cavity by using a residual oxygen detector.
2. The method of claim 1, wherein the gas collection bottle is a plastic bottle made of transparent material.
3. The method of claim 2, wherein the sealed end of the gas collection bottle is formed by a first rubber stopper.
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CN202010880978.7A CN112229947B (en) | 2020-08-27 | 2020-08-27 | Method for measuring residual oxygen amount of gas in ampoule bottle |
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