CN112229947A - Method for measuring residual oxygen amount of gas in ampoule bottle - Google Patents

Method for measuring residual oxygen amount of gas in ampoule bottle Download PDF

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Publication number
CN112229947A
CN112229947A CN202010880978.7A CN202010880978A CN112229947A CN 112229947 A CN112229947 A CN 112229947A CN 202010880978 A CN202010880978 A CN 202010880978A CN 112229947 A CN112229947 A CN 112229947A
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gas
bottle
gas collecting
water
collecting bottle
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CN202010880978.7A
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CN112229947B (en
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但作云
王亮
刘文军
罗成鑫
刘思川
谭鸿波
葛均友
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Sichuan Kelun Pharmaceutical Co Ltd
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Sichuan Kelun Pharmaceutical Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004Gaseous mixtures, e.g. polluted air
    • G01N33/0009General constructional details of gas analysers, e.g. portable test equipment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004Gaseous mixtures, e.g. polluted air
    • G01N33/0009General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

The invention provides a method for measuring the residual oxygen amount of gas in an ampoule bottle, and belongs to the technical field of residual oxygen amount measurement of gas in ampoule bottles. The method comprises the following steps: filling water with a preset height in the water tank, and completely immersing a gas collecting bottle with one end being a sealing end and one end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealing end of the gas collecting bottle is upward; slowly moving the gas collecting bottle upwards to enable the sealing end of the gas collecting bottle to be arranged outside the water surface, the opening end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealing end of the gas collecting bottle and the water surface; a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity; placing the ampoule bottle below the water surface and in the opening end of the gas collecting bottle; and breaking the ampoule bottle to discharge the gas in the ampoule bottle into the gas collection cavity, and detecting the gas in the gas collection cavity by using a residual oxygen detector. The invention can accurately measure the residual oxygen amount of the gas in the ampoule bottle and provide data support for product research and development.

Description

Method for measuring residual oxygen amount of gas in ampoule bottle
Technical Field
The invention belongs to the technical field of measurement of residual oxygen amount of gas in an ampoule bottle, and particularly relates to a method for measuring residual oxygen amount of gas in the ampoule bottle.
Background
A part of space inside the ampoule product is not filled with liquid medicine and contains oxygen, and the liquid medicine can react with the oxygen, particularly high-grade medicines are sensitive to the oxygen and are extremely easy to react with the oxygen, so that the curative effect and the storage period of the medicines are influenced.
Although protective nitrogen is filled before filling and wire drawing through a series of means, the proportion of the residual oxygen amount in the upper space of the product is not easy to detect, no data support is provided for product research and development, the actual oxygen content percentage of the product must be known, and a measurement method needs to be found.
Disclosure of Invention
The invention provides a method for measuring residual oxygen in ampoule bottle, which aims to solve the technical problem in the background technology.
In order to realize the development of applying the spina gleditsiae to shampoo, the invention adopts the following technical scheme:
a method for measuring the residual oxygen content of gas in an ampoule bottle comprises the following steps:
filling water with a preset height in the water tank, and completely immersing a gas collecting bottle with one end being a sealing end and one end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealing end of the gas collecting bottle is upward;
slowly moving the gas collecting bottle upwards to enable the sealing end of the gas collecting bottle to be arranged outside the water surface, the opening end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealing end of the gas collecting bottle and the water surface;
a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity;
placing the ampoule bottle below the water surface and in the opening end of the gas collecting bottle;
and breaking the ampoule bottle to discharge the gas in the ampoule bottle into the gas collection cavity, and detecting the gas in the gas collection cavity by using a residual oxygen detector.
Furthermore, the gas collecting bottle is a plastic bottle made of transparent materials.
Further, the sealed end of gas collecting bottle comprises first rubber buffer.
Further, the gas collecting bottle still includes the bottom, the bottom spiro union is at the open end of gas collecting bottle, just the middle part of bottom is equipped with the second rubber buffer, it has the cross mouth to draw on the second rubber buffer, be close to on the lateral wall of gas collecting bottle the breach has been seted up in the position of open end, be provided with the third rubber buffer in the breach, it has the cross mouth to draw on the third rubber buffer.
Compared with the prior art, the invention has the beneficial effects that:
the method provided by the invention can accurately measure the residual oxygen amount of the gas in the ampoule bottle, provides data support for product research and development, and provides an optimization basis for a process during production. Meanwhile, the method is low in cost and simple and convenient to operate.
Drawings
FIG. 1 is a schematic diagram of a system for measuring the residual oxygen content in an ampoule according to example 1 of the present invention;
fig. 2 is a schematic diagram of a gas collection bottle of a system required by the method for measuring the residual oxygen content of gas in an ampoule bottle in example 1 provided by the invention.
Fig. 3 is a schematic view of the bottom cap of the system for measuring the residual oxygen content in ampoule bottle according to the method of example 1.
Illustration of the drawings: 1-water tank, 2-water, 3-gas collecting bottle, 4-sealed end, 5-open end, 6-gas collecting cavity, 7-ampoule bottle, 8-bottom cover, 9-second rubber plug, 10-cross port and 11-third rubber plug.
Detailed Description
The present invention will be further described with reference to the following examples, which are intended to illustrate only some, but not all, of the embodiments of the present invention. Based on the embodiments of the present invention, other embodiments used by those skilled in the art without any creative effort belong to the protection scope of the present invention.
Example 1:
as shown in fig. 1, a method for measuring residual oxygen in ampoule 7 comprises the following steps:
s100: filling water 2 with a preset height in a water tank 1, and completely immersing a gas collecting bottle 3 with a sealing end 4 at one end and an opening end 5 at the other end in the water 2; after the gas collecting bottle 3 is filled with water 2, turning over the gas collecting bottle 3 in the water 2 to enable the sealing end 4 of the gas collecting bottle 3 to face upwards;
in this step, the water 2 with a predetermined height is typically 80% of the water 2 pre-filled in the water tank 1, and the water 2 fills the gas-collecting bottle 3 from the opening end 5 in order to exhaust the gas inside the gas-collecting bottle 3.
S200: slowly moving the gas collecting bottle 3 upwards to enable the sealing end 4 of the gas collecting bottle 3 to be arranged outside the water 2 surface, the opening end 5 of the gas collecting bottle 3 to be arranged below the water 2 surface, and a gas collecting cavity 6 is formed between the sealing end 4 of the gas collecting bottle 3 and the water 2 surface; at this time, the gas collecting chamber 6 is free of any gas.
The gas collection bottle 3 is preferably a plastic bottle made of transparent material, and the sealing end 4 of the gas collection bottle 3 is made of a first rubber plug, so that a rubber plug is selected to facilitate the insertion of the needle of the residual oxygen detector into the gas collection chamber 6 through the sealing of the rubber plug, so as to facilitate the detection of the gas in the ampoule bottle 7 collected in the gas collection chamber 6.
Meanwhile, the transparent material is also used for facilitating an operator to watch the liquid level in the gas collecting cavity 6.
S300: the needle head of the residual oxygen detector is hermetically inserted into the gas collection cavity 6;
the model of the residual oxygen detector used is OXYBABY 6io 2.
S400: placing the ampoule bottle 7 below the water 2 and in the opening end 5 of the gas collecting bottle 3;
in this step, in order to prevent the gas in the ampoule bottle 7 from escaping to the outside of the gas collecting bottle 3 after the ampoule bottle 7 is broken, the ampoule bottle 7 is placed inside the opening end 5 of the gas collecting bottle 3 as much as possible, and when the ampoule bottle 7 is broken, the above operations all need to be performed with a small amplitude by means of tools such as tweezers, so as to prevent other gases from entering the gas collecting cavity 6 of the gas collecting bottle 3 and interfering with the test result.
S500: and breaking the ampoule bottle 7, discharging the gas in the ampoule bottle 7 into the gas collection cavity 6, and detecting the gas in the gas collection cavity 6 by using a residual oxygen detector.
In the case of the 1 ml ampoule bottle 7, the gas is not easily discharged, and the gas is discharged by lightly tapping several times with a finger. After the gas in one ampoule bottle 7 is exhausted, the second ampoule bottle 7 is broken off until enough gas is in the gas collecting cavity 6 at the upper part of the gas collecting bottle 3 and can be detected for more than two times, the gas collecting bottle 3 is kept in the water 2 all the time, the gas above the plastic bottle is detected by using a residual oxygen meter, the oxygen content of the part of gas is measured, the detection can be performed for two times, whether the residual oxygen values are consistent or not is judged, the difference is very small actually, and the detection is basically an average value.
Example 2
As shown in fig. 1-3, the method of measuring residual oxygen content in gas in ampoule 7 that this embodiment provided, the same part with embodiment 1 is no longer repeated, and the difference lies in, in this embodiment, gas collecting bottle 3 still includes bottom 8, 8 spiro couplings of bottom are at gas collecting bottle 3's open end 5, just bottom 8's middle part is equipped with second rubber buffer 9, it has cross mouth 10 to mark on the second rubber buffer 9, be close to on gas collecting bottle 3's the lateral wall set up jaggedly in open end 5's the position, be provided with third rubber buffer 11 in the breach, it has cross mouth 10 to mark on third rubber buffer 11.
In this embodiment, add bottom 8, when the ampoule 7 is broken, ensure that gas is all collected in gas collecting chamber 6, further improve the accuracy of detecting. For this purpose, a cross 10 is scored on the second rubber plug 9, a cross 10 is scored on the third rubber plug 11, so that, in the process of turning over the gas collecting bottle 3 under the water 2 and slowly moving upwards to form the gas collecting cavity 6, the bottom cover 8 is not installed, when the sealed end 4 of the gas collecting bottle 3 is arranged outside the water 2 surface and the open end 5 of the gas collecting bottle 3 is arranged below the water 2 surface, the position of the gas collecting bottle 3 is kept, a knob is arranged on a bottom cover 8 under water 2 at the opening end 5 of the gas collecting bottle 3, then an ampoule bottle 7 is deeply inserted into the gas collecting bottle 3 through a cross-shaped opening 10 scribed on a second rubber plug 9, then, a tool for opening the ampoule bottle 7, such as a pair of tweezers, is deeply inserted into the gas collection bottle 3 through the cross-shaped opening 10 scribed on the third rubber plug 11, so as to complete breaking and opening of the ampoule bottle 7, release the gas therein, and escape into the gas collection chamber 6, thereby completing detection.
This embodiment is through making further optimization and improvement to gas-collecting bottle 3 for gas-collecting chamber 6 is more accurate when gathering the gas in ampoule 7, is favorable to improving the detection precision.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (4)

1. A method for measuring residual oxygen in ampoule bottle is characterized by comprising the following steps:
filling water with a preset height in the water tank, and completely immersing a gas collecting bottle with one end being a sealing end and one end being an opening end in the water; after the gas collecting bottle is filled with water, the gas collecting bottle is turned over in the water, so that the sealing end of the gas collecting bottle is upward;
slowly moving the gas collecting bottle upwards to enable the sealing end of the gas collecting bottle to be arranged outside the water surface, the opening end of the gas collecting bottle to be arranged below the water surface, and a gas collecting cavity is formed between the sealing end of the gas collecting bottle and the water surface;
a needle head of a residual oxygen detector is hermetically inserted into the gas collection cavity;
placing the ampoule bottle below the water surface and in the opening end of the gas collecting bottle;
and breaking the ampoule bottle to discharge the gas in the ampoule bottle into the gas collection cavity, and detecting the gas in the gas collection cavity by using a residual oxygen detector.
2. The method of claim 1, wherein the gas collection bottle is a plastic bottle made of transparent material.
3. The method of claim 2, wherein the sealed end of the gas collection bottle is formed by a first rubber stopper.
4. The method according to claim 2, wherein the gas collection bottle further comprises a bottom cap, the bottom cap is screwed to the opening end of the gas collection bottle, a second rubber plug is arranged in the middle of the bottom cap, a cross opening is formed in the second rubber plug, a notch is formed in the side wall of the gas collection bottle at a position close to the opening end, a third rubber plug is arranged in the notch, and a cross opening is formed in the third rubber plug.
CN202010880978.7A 2020-08-27 2020-08-27 Method for measuring residual oxygen amount of gas in ampoule bottle Active CN112229947B (en)

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