CN112220446A - Mouse cataract detection equipment - Google Patents
Mouse cataract detection equipment Download PDFInfo
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- CN112220446A CN112220446A CN202011175380.4A CN202011175380A CN112220446A CN 112220446 A CN112220446 A CN 112220446A CN 202011175380 A CN202011175380 A CN 202011175380A CN 112220446 A CN112220446 A CN 112220446A
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- 238000001514 detection method Methods 0.000 title claims abstract description 81
- 208000002177 Cataract Diseases 0.000 title claims abstract description 44
- 238000010171 animal model Methods 0.000 claims abstract description 33
- 210000000744 eyelid Anatomy 0.000 claims description 25
- 210000001508 eye Anatomy 0.000 claims description 10
- 210000001503 joint Anatomy 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 abstract description 18
- 241000699666 Mus <mouse, genus> Species 0.000 description 60
- 238000005192 partition Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 210000005252 bulbus oculi Anatomy 0.000 description 3
- 210000000695 crystalline len Anatomy 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 102000014824 Crystallins Human genes 0.000 description 1
- 108010064003 Crystallins Proteins 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000030212 nutrition disease Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
- A61B3/1173—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens
- A61B3/1176—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens for determining lens opacity, e.g. cataract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0083—Apparatus for testing the eyes; Instruments for examining the eyes provided with means for patient positioning
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- Ophthalmology & Optometry (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
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Abstract
The invention relates to the technical field of biological detection equipment, in particular to mouse cataract detection equipment which comprises a fixed base, wherein symmetrically distributed supporting plates are arranged on the surface of the fixed base and close to two ends of the fixed base, a workbench is arranged at the top of each supporting plate, a detection box is arranged on the surface of the workbench and close to the left end of the workbench, an experimental animal platform is arranged at the bottom of the inner wall of the detection box, a mouse fixing device is movably connected to the top of the experimental animal platform and located at the front side of the experimental animal platform, a flash stimulator is arranged on the surface of the experimental animal platform and located at the middle part of the rear side of the experimental animal platform, and an electrophysiological computer is arranged on the surface of the workbench and close to the right. This mouse cataract test equipment can provide the detection ring border who is equivalent to the darkroom through the detection case, can prevent the wire confusion through the L shape baffle that is equipped with and guide ring to avoid the wire to influence the normal work of the amazing ware that flashes, can fix the mouse on placing the platform through last bandage and lower bandage that is equipped with.
Description
Technical Field
The invention relates to the technical field of biological detection equipment, in particular to mouse cataract detection equipment.
Background
Cataract refers to the condition that the metabolic disorder of crystalline lens caused by aging, heredity, local nutrition disorder, immunity and metabolism abnormality, radiation and the like causes the degeneration of crystalline lens protein to generate opacity, a series of basic and clinical problems about the pathogenesis, diagnosis and treatment of cataract are still to be further studied, cataract has high heredity heterogeneity, any gene mutation related to the development and differentiation of crystalline lens can form hereditary cataract, so that the pathogenic genes of cataract are also many, therefore, a large number of cataract animal models need to be made, important carriers are provided for basic and clinical researches such as the pathogenesis, disease course development, drug development and drug effect evaluation of cataract, the cataract test is carried out by using mice, the mice in the test are placed in a dark room, and the eyes of the mice are observed by cataract detection equipment, The required test data is recorded and analyzed, but the existing mouse cataract detection equipment must be in a dark room to carry out the test, and the use of the mouse cataract detection equipment is limited due to the limitation of conditions, so that the detection is inconvenient.
Disclosure of Invention
The invention aims to provide a mouse cataract detection device, which aims to solve the problem that the existing mouse cataract detection device in the background technology needs to be in a dark room to perform a test, and the use of the mouse cataract detection device is limited due to the limitation of conditions, so that the detection is inconvenient.
In order to achieve the purpose, the invention provides the following technical scheme:
a mouse cataract detection device comprises a workbench, a detection box, a mouse fixing device, an eyelid expanding device, an electrophysiological computer and a flash stimulator, wherein the detection box is arranged on the workbench; the front side of the detection box is hinged with a single-door which can be opened outwards, an experimental animal platform which can be taken out is arranged in the detection box, and the mouse fixing device is arranged on the experimental animal platform and can move along the width direction of the detection box; the eyelid opening devices are provided with two groups and are arranged on the mouse fixing device at intervals and used for opening two eyes of a mouse; the flash stimulator is arranged on the surface of the experimental animal platform and is positioned at the end far away from the single-door opening, the surface of the workbench is provided with an electrophysiological computer, and the flash stimulator is in communication connection with the electrophysiological computer.
Preferably, a strip-shaped groove is formed in the surface of the experimental animal platform and along the wide edge of the experimental animal platform, the strip-shaped groove is located at one end, close to the single-door, of the single-door, and a strip-shaped plate is arranged in the strip-shaped groove; two T-shaped sliding grooves are formed in the experimental animal platform at intervals along the long edge direction of the experimental animal platform; the bottom of the mouse fixing device is provided with a T-shaped sliding block, and the T-shaped sliding block is connected in the T-shaped sliding groove in a sliding mode.
Preferably, the mouse fixing device comprises a moving plate, and the T-shaped sliding block is arranged at the bottom of the moving plate; the movable plate is characterized in that a placing table is arranged on the surface of the movable plate, a first upper binding band and a second upper binding band are arranged on the surface of the movable plate and close to the edge of one side close to the placing table at intervals, a first lower binding band and a second lower binding band are arranged on the surface of the movable plate and close to the edge of the other side of the placing table at intervals, and the first upper binding band and the second upper binding band can be in butt joint with the corresponding first lower binding band and the second lower binding band.
Preferably, the eyelid opening device includes erection column, connecting rod and the clamp of strutting, the vertical setting of erection column is in the movable plate, and erection column height is adjustable, the erection column top is equipped with the guide arm, connecting rod one end is provided with the lantern ring, just the lantern ring cover is established on the guide arm, it sets up to strut the clamp the other one end of connecting rod.
Preferably, the mounting column comprises a sleeve, a support column and a locking nut; the sleeve is vertically arranged on the moving plate, and a threaded hole communicated with an inner cavity of the sleeve is formed in the side wall of the sleeve; the supporting column is inserted into the sleeve in a sliding manner, and the guide rod is arranged at the top end of the supporting column; the locking nut is in threaded connection with the threaded hole, and can be abutted against the supporting column by rotating the locking nut.
Preferably, the expanding clamp comprises a trunk, a first pressing plate, a second pressing plate, a connecting frame, a clamping rod and an adjusting screw rod; the trunk is arranged on the connecting rod, two guide rods are arranged at the end part of the trunk, which is far away from the connecting rod, and the two guide rods form an inverted Y shape; the first pressing plate is connected between the two guide rods, two ends of the second pressing plate are sleeved on the guide rods in a sliding mode, one side, away from the first pressing plate, of the second pressing plate is provided with a connecting frame, the middle of the clamping rod is hinged to the trunk, the head end of the clamping rod is hinged to the connecting frame, and the tail end of the connecting frame is provided with a through hole; a stop block is arranged at one end of the adjusting screw rod, and the other end of the adjusting screw rod penetrates through the through hole to be in threaded connection with the trunk.
Preferably, the guide rod is a threaded rod, and a fastening nut is connected to the end of the guide rod in a threaded manner.
Preferably, the device also comprises a fixed base, two support plates are vertically and upwards arranged on the surface of the fixed base at intervals, and the workbench is arranged on the tops of the two support plates; a transverse plate is arranged between the two supporting plates; self-braking universal wheels are arranged at the bottom of the fixed base and close to the four corners; and a push rod is arranged on the surface of the fixed base and positioned at the edge of the left side.
Preferably, the surface of the experimental animal platform is vertically provided with two first upright columns at intervals, and the top ends of the first upright columns are provided with guide rings.
Preferably, two L-shaped partition plates are arranged in the detection box at intervals at one end far away from the single-door, and the two L-shaped partition plates are symmetrically arranged at two sides of the flash stimulator.
Compared with the prior art, the invention has the beneficial effects that:
1. this mouse cataract test equipment, the unable adjustment base through being equipped with, from stopping universal wheel and push rod can the person of facilitating the use remove this test equipment, can provide the detection environment who is equivalent to the darkroom through the detection case.
2. This mouse cataract measurement equipment can be used for placing the experimental article such as the required reagent of mouse or experiment to be detected through the diaphragm that is equipped with.
3. This mouse cataract measurement equipment can prevent that wire, detection line are chaotic through the L shape baffle and the guide ring that are equipped with to avoid wire, detection line to influence the normal work of flash of light stimulator.
4. The mouse eyelid is stretched by the eyelid stretching device, so that the detection is convenient.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a cataract testing apparatus for mice according to the present invention;
FIG. 2 is a schematic diagram of the inner wall of the detection box of the mouse cataract detection device shown in FIG. 1;
FIG. 3 is a schematic structural diagram of a platform of an experimental animal in the apparatus for detecting cataract of a mouse shown in FIG. 1;
FIG. 4 is a bottom view of the moving plate of the mouse cataract testing apparatus shown in FIG. 1;
FIG. 5 is a schematic structural diagram of a mouse fixing device in the mouse cataract testing apparatus shown in FIG. 1;
FIG. 6 is a schematic structural diagram of an eyelid retractor in the mouse cataract testing apparatus shown in FIG. 1;
fig. 7 is a schematic structural view of a spreading clip in the eyelid spreading device in the mouse cataract testing apparatus shown in fig. 1;
FIG. 8 is a schematic view of the assembly of the table and the supporting plate of the mouse cataract testing apparatus shown in FIG. 1;
in the figure: the device comprises a fixed base 1, a self-braking universal wheel 10, a push rod 11, a support plate 12, a transverse plate 120, a protection plate 120, a workbench 2, a detection box 3, a single-opening door 30, an L-shaped partition plate 31, an electrophysiological computer 4, an experimental animal platform 5, a strip-shaped groove 50, a strip-shaped plate 51, a T-shaped sliding groove 52, a first upright 53, a guide ring 530, a mouse fixing device 6, a moving plate 60, a placing table 61, a first upper binding belt 62, a first lower binding belt 63, a second upper binding belt 64, a second lower binding belt 65, a second upright 66, a threaded rod 660, a fastening nut 6600, an annular fixing block 67, a connecting rod 670, a clamp 68, a T-shaped sliding block 69, an eyelid opening device 7, a mounting column 71, a sleeve 711, a support column 712, a locking nut 713, a collar 72, a guide rod 73, a fastening nut 74, a connecting rod 75, an opening clamp 76, a trunk 761, a first pressing plate 767653, a second pressing plate, a connecting, A flashing stimulator 8.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Referring to fig. 1 to 8, the present invention provides a technical solution:
referring to fig. 1 and 2, a mouse cataract detecting device comprises a fixing base 1, a detecting box 3, a mouse fixing device 6, an eyelid opening device 7, an electrophysiological computer 4 and a flash stimulator 8. The detection box 3 is arranged on the workbench 2. The detection box 3 is used for providing a detection environment equivalent to a darkroom. The front side of the detection box 3 is hinged with a single-door 30. An experimental animal platform 5 which can be taken out is arranged in the detection box 3. The experimental animal platform 5 is convenient for shift out the whole device that detects from the detection case 3, the maintenance of the later stage of being convenient for. The mouse fixing device 6 is arranged on the experimental animal platform 5 and can move along the width direction of the detection box 3; the eyelid opening devices 7 are arranged in two groups at intervals on the mouse fixing device 6 and are used for opening the eyelids of the two eyes of the mouse. The flash stimulator 8 is arranged on the surface of the experimental animal platform 5 and is positioned at one end far away from the single-opening door 30. The flash stimulator 8 is used to generate a source of detection flashes. An electrophysiological computer 4 is provided on the surface of the table 2 near the right end. The flash stimulator 8 is connected to the electrophysiological computer 4 in a communication manner, and the electrophysiological computer 4 can analyze and display the detection data.
Referring to fig. 3 and 4, a strip-shaped groove 50 is formed on the surface of the experimental animal platform 5 along the wide side thereof, and the strip-shaped groove 50 is located at one end of the single-door 30. A strip plate 51 is provided in the strip groove 50. Further, the side threaded connection of bar 51 through screw and bar recess 50 inner walls, the installation and the dismantlement of the bar 51 of being convenient for to the person of facilitating the use dismantles mouse fixing device 6 from experimental animals platform 5. Two T-shaped sliding grooves 52 are formed in the experimental animal platform 5 at intervals along the long side direction of the experimental animal platform, and the T-shaped sliding blocks 69 are connected in the T-shaped sliding grooves 52 in a sliding mode. During detection, the mouse fixing device 6 can be pushed, and the distance between the mouse fixing device 6 and the flash stimulator 8 can be adjusted, so that accurate detection is facilitated.
Referring to fig. 5, in particular, the mouse fixing device 6 includes a moving plate 60. The bottom of the moving plate 60 is provided with a T-shaped slide block 69, and the bottom of the moving plate 60 is provided with the T-shaped slide block 69. The moving plate 60 is provided with a placing table 61 on the surface, and the placing table 61 is used for placing a mouse to be detected. The surface of the moving plate 60 is provided with a first upper strap 62 and a second upper strap 64 at intervals close to one side edge of the placing table 61, the surface of the moving plate 60 is provided with a first lower strap 63 and a second lower strap 65 at intervals close to the other side edge of the placing table 61, and the first upper strap 62 and the second upper strap 64 can be butted with the corresponding first lower strap 63 and second lower strap 65. During detection, the body of the mouse is fixed by the butt joint of the second upper bandage 64 and the second lower bandage 65, and the head of the mouse is fixed by the butt joint of the first upper bandage 62 and the first lower bandage 63, so that the mouse is fixed, and the change of the outside of the mouse in the detection process is prevented.
Referring to fig. 2, 5 and 6, there are two sets of eyelid opening devices 7, which are disposed on the mouse fixing device 6 at intervals for opening two eyes of the mouse for detection. Specifically, the eyelid opening device 7 includes a mounting column 71, a connecting rod 75 and an opening clip 76, the mounting column 71 is vertically disposed on the moving plate 60, the height of the mounting column 71 is adjustable, a guide rod 73 is disposed at the top end of the mounting column 71, a sleeve ring 72 is disposed at one end of the connecting rod, the sleeve ring 72 is sleeved on the guide rod 73, and the opening clip 76 is disposed at the other end of the connecting rod 75. During detection, the mouse is fixed by the second upper bandage and the second lower bandage 65, the first upper bandage 62 and the first lower bandage 63, then the connecting rod 75 is used for aligning the expanding clamp 76 with the eyes of the mouse, and the eyes of the mouse are expanded by the expanding clamp 76. Preferably, the guide rod 73 is a threaded rod, and a fastening nut 74 is screwed to an end of the guide rod 73. The collar 72 is secured by a fastening nut 74 to prevent the position of the distraction clip 76 from changing.
Referring to fig. 6, the mounting post 71 includes a sleeve 711 and a support post 712 and a retaining nut 713. The sleeve 711 is vertically arranged on the moving plate 60, and a threaded hole communicated with the inner cavity of the sleeve 711 is formed in the side wall of the sleeve 711. The support column 712 is slidably inserted into the sleeve 711, and the guide rod 73 is provided at the top end of the support column 712. The lock nut 713 is in threaded connection with the threaded hole, and when the lock nut 713 is rotated, the lock nut 713 can abut against the support column 712. When the height needs to be adjusted, the locking nut 713 is loosened, then the supporting column 712 is pulled, the position is adjusted, the locking nut 713 is rotated reversely to lock the rotating locking nut, and the eyelid retractor 7 can be accurately aligned with the eyes of the mouse.
Referring to fig. 7, the expanding clamp 76 includes a stem 761, a first pressing plate 762, a second pressing plate 763, a connecting frame 764, a clamping rod 765, and an adjusting screw 766. The stem 761 is disposed on the connecting rod 75, and the end of the stem 761 away from the connecting rod 75 is provided with two guiding rods 767, and the two guiding rods 767 form an inverted Y shape. The first pressing plate 762 is connected between two guide rods 767. Two ends of the second pressing plate 763 can be slidably sleeved on the guide rods 767. A connecting bracket 764 is disposed on a side of the second pressing plate 763 away from the first pressing plate 762. The middle part of clamping rod 765 is articulated with backbone 761, the head end of clamping rod 765 is articulated with link 764, the tail end of link 764 has seted up the via hole. One end of the adjusting screw 766 is provided with a stopper, and the other end of the adjusting screw 766 penetrates through the via hole to be in threaded connection with the stem 761. In particular, the sides of the first and second pressing plates 762 and 763 facing the eyes can be configured to conform to the arc shape of the eyeball, so as to not only fit the eyelid of the eye, but also increase comfort.
When the eyelid needs to be stretched, the height of the mounting column 71 and the angle of the adjusting connecting rod 75 are adjusted first, so that the first pressing plate 762 is aligned with the lower eyelid, the second pressing plate 763 is aligned with the upper eyelid, the adjusting screw 766 is rotated, the second pressing plate 763 is driven to slowly move along the guide rod 767 through the clamping rod 765, the distance between the first pressing plate 762 and the second pressing plate 763 is gradually increased, the eyelid can be stretched, the eyeball is exposed, and detection is performed.
Referring to fig. 3, further, two first vertical columns 53 are vertically arranged on the surface of the experimental animal platform 5 at intervals, and the top ends of the first vertical columns 53 are provided with guide rings 530. The guide ring 530 can limit the wires and the detection lines on the mouse body, and prevent the wires and the detection lines from collapsing downwards. Furthermore, two L-shaped partition plates 31 are arranged in the detection box 3 at intervals at one end far away from the single-door 30, and the two L-shaped partition plates 31 are symmetrically arranged at two sides of the flash stimulator 8. The L-shaped partition plates 31 further group the leads and the detection lines, and can prevent the leads and the detection lines from being disordered, so that the leads and the detection lines are prevented from influencing the normal work of the flash stimulator 8.
Referring to fig. 1 and 8, in the present embodiment, two support plates 12 are vertically disposed on the surface of the fixing base 1 in an upward direction at intervals, and the worktable 2 is disposed on the tops of the two support plates 12. A transverse plate 120 and a baffle 1200 are arranged between the supporting plates 12 and can be used for placing test articles such as a mouse to be tested or reagents required by a test and preventing the articles from falling. The bottom of unable adjustment base 1 and the position that is close to four corners all are equipped with from universal wheel 10 of stopping, the removal of this check out test set of being convenient for. The surface of the fixed base 1 and the position at the left side edge are provided with a push rod 11, which is convenient for a user to move the detection device. A handle may be provided at a position near the middle of the right end of the front side of the single-opening door 30, which is convenient for a user to open the single-opening door 30.
The specific use mode of the mouse cataract detection equipment is as follows:
when the mouse cataract detection device of the embodiment is used, a user pushes the detection device to a required area through the push rod 11, then opens the single-door 30, pulls out the moving plate 60, places the mouse which has been anesthetized on the placing table 61, fixes the neck of the mouse through the first upper binding band 62 and the first lower binding band 63, and fixes the back of the mouse through the second upper binding band 64 and the second lower binding band 65, so that the position of the mouse is fixed.
Subsequently, according to the body type of the mouse, the height of the mounting column 71 is adjusted, then the fastening nut 74 is loosened, the angles of the connecting rod 75 and the expanding clamp 76 are adjusted, the first pressing plate 762 and the second pressing plate 763 on the expanding clamp 76 are aligned to the lower eyelid and the upper eyelid of the mouse respectively, then the adjusting screw 766 is rotated, the second pressing plate 763 is driven to move slowly along the guide rod 767 through the clamping rod 765, the distance between the first pressing plate 762 and the second pressing plate 763 is gradually increased, the eyelid can be expanded, eyeballs can be exposed, and detection is carried out. And finally, after the detection lead and the detection line required by the body of the mouse are fixed, the pushing moving plate 60 is pushed to the detection position, the single-door 30 is closed to enable the mouse to be in a darkroom environment, and finally the flash stimulator 8 is opened to carry out test detection, the detected data can be input into the electrophysiological computer 4 through the lead and the detection line, and the electrophysiological computer 4 analyzes and displays the data.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A mouse cataract detection device is characterized in that: the device comprises a workbench (2), a detection box (3), a mouse fixing device (6), an eyelid opening device (7), an electrophysiological computer (4) and a flash stimulator (8), wherein the detection box (3) is arranged on the workbench (2); the front side of the detection box (3) is hinged with a single-door (30) capable of being opened outwards, an experimental animal platform (5) capable of being taken out is arranged in the detection box (3), and a fixing device of the mouse fixing device (6) is arranged on the experimental animal platform (5) and can move along the width direction of the detection box (3); the eyelid opening devices (7) are arranged in two groups and are arranged on the mouse fixing device (6) at intervals and used for opening the two eyes of the mouse; flash of light stimulator (8) sets up experimental animals platform (5) on the surface and be located and keep away from singly open door (30) one end, the surface of workstation (2) is equipped with electrophysiological computer (4), just flash of light stimulator (8) with electrophysiological computer (4) communication connection.
2. The mouse cataract detection apparatus as claimed in claim 1, wherein: a strip-shaped groove (50) is formed in the surface of the experimental animal platform (5) and along the wide edge of the experimental animal platform, the strip-shaped groove (50) is located at one end, close to the single-door opening (30), of the single-door opening, and a strip-shaped plate (51) is arranged in the strip-shaped groove (50); two T-shaped sliding grooves (52) are formed in the experimental animal platform (5) at intervals along the long side direction of the experimental animal platform; the bottom of the mouse fixing device (6) is provided with a T-shaped sliding block (69), and the T-shaped sliding block (69) is connected in the T-shaped sliding groove (52) in a sliding manner.
3. The mouse cataract detection apparatus as claimed in claim 2, wherein: the mouse fixing device (6) comprises a moving plate (60), and the T-shaped sliding block (69) is arranged at the bottom of the moving plate (60); the movable plate is characterized in that a placing table (61) is arranged on the surface of the movable plate (60), a first upper binding band (62) and a second upper binding band (64) are arranged on the surface of the movable plate (60) and close to the edge of one side close to the placing table (61) at intervals, a first lower binding band (63) and a second lower binding band (65) are arranged on the surface of the movable plate (60) and close to the edge of the other side of the placing table (61) at intervals, and the first upper binding band (62) and the second upper binding band (64) can be in butt joint with the corresponding first lower binding band (63) and the second lower binding band (65).
4. The mouse cataract detection apparatus as claimed in claim 1, wherein: eyelid distraction device (7) include erection column (71), connecting rod (75) and strut and press from both sides (76), erection column (71) vertical setting is in moving plate (60), and erection column (71) height-adjustable, erection column (71) top is equipped with guide arm (73), connecting rod (75) one end is provided with lantern ring (72), just lantern ring (72) cover is established on guide arm (73), strut and press from both sides (76) and set up the other one end of connecting rod (75).
5. The mouse cataract detection apparatus as claimed in claim 4, wherein: the mounting post (71) comprises a sleeve (711), a support post (712) and a locking nut (713); the sleeve (711) is vertically arranged on the moving plate (60), and a threaded hole communicated with the inner cavity of the sleeve (711) is formed in the side wall of the sleeve (711); the supporting column (712) is slidably inserted into the sleeve (711), and the guide rod (73) is arranged at the top end of the supporting column (712); the locking nut (713) is in threaded connection with the threaded hole, the locking nut (713) is rotated, and the locking nut (713) can abut against the supporting column (712).
6. The mouse cataract detection apparatus as claimed in claim 5, wherein: the expanding clamp (76) comprises a trunk (761), a first pressing plate (762), a second pressing plate (763), a connecting frame (764), a clamping rod (765) and an adjusting screw rod (766); the trunk (761) is arranged on the connecting rod (75), two guide rods (767) are arranged at the end part of the trunk (761) far away from the connecting rod (75), and the two guide rods (767) form an inverted Y shape; the first pressing plate (762) is connected between the two guide rods (767), two ends of the second pressing plate (763) are slidably sleeved on the guide rods (767), one side, away from the first pressing plate (762), of the second pressing plate (763) is provided with a connecting frame (764), the middle of the clamping rod (765) is hinged to the trunk (761), the head end of the clamping rod (765) is hinged to the connecting frame (764), and the tail end of the connecting frame (764) is provided with a through hole; one end of the adjusting screw rod (766) is provided with a stop block, and the other end of the adjusting screw rod (766) penetrates through the via hole to be in threaded connection with the trunk (761).
7. The mouse cataract detection apparatus as claimed in claim 2, wherein: the guide rod (73) is a threaded rod, and the end part of the guide rod (73) is connected with a fastening nut (74) in a threaded manner.
8. The mouse cataract detection apparatus as claimed in claim 1, wherein: the worktable is characterized by further comprising a fixed base (1), wherein two supporting plates (12) are arranged on the surface of the fixed base (1) in a vertically upward mode at intervals, and the worktable (2) is arranged at the tops of the two supporting plates (12); a transverse plate (120) is arranged between the two support plates (12); self-braking universal wheels (10) are arranged at the bottom of the fixed base (1) and close to the four corners; and a push rod (11) is arranged on the surface of the fixed base (1) and positioned at the left side edge.
9. The mouse cataract detection apparatus as claimed in claim 1, wherein: the surface of the experimental animal platform (5) is vertically provided with two first upright columns (53) at intervals, and the top ends of the first upright columns (53) are provided with guide rings (530).
10. The mouse cataract detection apparatus as claimed in claim 1, wherein: two L-shaped clapboards (31) are arranged in the detection box (3) and far away from one end of the single-door (30) at intervals, and the two L-shaped clapboards (31) are symmetrically arranged at two sides of the flash stimulator (8).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011175380.4A CN112220446B (en) | 2020-10-28 | 2020-10-28 | Mouse cataract detection equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011175380.4A CN112220446B (en) | 2020-10-28 | 2020-10-28 | Mouse cataract detection equipment |
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| CN112220446B CN112220446B (en) | 2024-01-30 |
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|---|---|---|---|---|
| KR20040087111A (en) * | 2003-04-04 | 2004-10-13 | (주)지노첵 | Mouse as Model for Cataract and a Method of Production Thereof |
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| US20100105098A1 (en) * | 2006-06-29 | 2010-04-29 | Peter Frederiske | Methods of Identifying Disease Biomarkers in the Lense of the Eye |
| CN111269944A (en) * | 2020-02-05 | 2020-06-12 | 青岛大学 | Mouse cataract animal model and application thereof |
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2020
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| EP1913866A1 (en) * | 2000-08-21 | 2008-04-23 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
| KR20040087111A (en) * | 2003-04-04 | 2004-10-13 | (주)지노첵 | Mouse as Model for Cataract and a Method of Production Thereof |
| US20100105098A1 (en) * | 2006-06-29 | 2010-04-29 | Peter Frederiske | Methods of Identifying Disease Biomarkers in the Lense of the Eye |
| CN111269944A (en) * | 2020-02-05 | 2020-06-12 | 青岛大学 | Mouse cataract animal model and application thereof |
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