CN112168394A

CN112168394A - Device and method for fusing surfaces of autologous concentrated growth factor implants

Info

Publication number: CN112168394A
Application number: CN202011171041.9A
Authority: CN
Inventors: 李泽南
Original assignee: Beijing Yirui Technology Co ltd
Current assignee: Li Zenan
Priority date: 2020-10-28
Filing date: 2020-10-28
Publication date: 2021-01-05

Abstract

The invention provides a device and a method for fusing the surface of an autologous concentrated growth factor implant, relates to the field of oral implantation, and solves the technical problem of rejection reaction caused by individual difference in the existing implant surface treatment. The device comprises a tubular bottle body, wherein two open ends of the bottle body are respectively provided with a bottom seal and an upper cover, and the bottom seals are made of elastic materials; the upper cover is detachably arranged on the bottle body, and the built-in converter can be in adaptive connection with the carrier of the implant. When the upper cover connected with the implant is arranged back to the bottle body, the implant can be immersed in autologous blood, and the fusion device is placed on a centrifuge to separate the autologous concentrated growth factors; the implant can be immersed in the high-concentration growth factors, the concentration growth factors are attached to the gaps on the surface of the implant to form an autologous surface, the fusion and reformation of the implant and bones are accelerated, the rejection reaction when foreign matters are implanted is reduced, and the survival rate of the implant is increased.

Description

Device and method for fusing surfaces of autologous concentrated growth factor implants

Technical Field

The invention relates to the technical field of oral implantation, in particular to a device and a method for fusing the surface of an autologous concentrated growth factor implant.

Background

The oral implant is also called a dental implant, and is also called an artificial tooth root. It is implanted into the upper and lower jawbone of the edentulous part of human body by means of surgical operation, and after the operation wound is healed, the false tooth repairing device is mounted on the upper portion of the false tooth repairing device.

The existing implant is mostly made of four-grade and five-grade medical titanium, inductive osteogenesis materials are sprayed on the surface of the implant (RBM), or surface treatment modes such as adding osteogenesis factors (SLA) after acid etching and the like are adopted, so that the surface of the implant is in contact with bones, the affinity is higher, and the integration of the implant and the bones can be rapidly promoted.

The applicant has found that the prior art has at least the following technical problems:

the surface treatment of the implant comprises physical coarsening, chemical acid etching or biological activation treatment, although the surface treatment of the implant is greatly developed in recent years, most of the surface treatment of the implant is prepared in a production line in a unified way, and the individual difference of a human body and the rejection reaction when foreign matters are implanted are not fully solved, so that the failure of the dental implant operation can be caused.

Disclosure of Invention

The invention aims to provide a device and a method for fusing the surface of an autologous growth factor implant, which are used for solving the technical problems that the surface treatment of the implant in the prior art does not fully solve the individual difference of a human body and the rejection reaction when foreign matters are implanted. The technical effects that can be produced by the preferred technical scheme in the technical schemes provided by the invention are described in detail in the following.

In order to achieve the purpose, the invention provides the following technical scheme:

the invention provides a self-concentration growth factor implant surface fusion device which comprises a tubular bottle body, wherein two opening ends of the bottle body are respectively provided with a bottom seal and an upper cover, and the bottom seals are made of elastic materials; the upper cover is detachably arranged on the bottle body, a converter is arranged on the inner side of the upper cover, and the converter can be in adaptive connection with a carrier of an implant.

Optionally, the converter is sleeved with an annular sealing member capable of sealing a gap between the converter and the bottle body. Isolating the containing cavity of the bottle body from the outside

Optionally, the converter and the upper cover are integrally formed or detachably connected in a snap-fit manner.

Optionally, one side of the bottom seal, which is close to the accommodating cavity of the bottle body, is provided with a first concave structure.

Optionally, one side of the bottom seal, which is far away from the accommodating cavity of the bottle body, is provided with a second concave structure.

Optionally, the first recessed structure and the second recessed structure are both rounded transition curved surfaces.

Optionally, the bottom seal is a rubber plug that fits tightly to the bottle body.

Optionally, the inner wall of the bottle body is provided with an anti-collision member.

The invention provides a fusion method of the surface of an autologous concentrated growth factor implant, which adopts any one of the fusion devices to fuse the concentrated growth factor with the surface of the implant; the method comprises a blood sampling step, an implant placing step, a centrifugal preparation step and a fusion step.

Optionally, the step of drawing blood comprises:

s11, extracting autologous blood of the patient;

and S12, injecting the collected blood into the accommodating cavity of the bottle body.

Alternatively, in step S12, a lancet is inserted into the bottom seal to inject or suck blood into the bottle.

Optionally, the implant placing step comprises:

s21, separating the upper cover from the bottle body;

s22, connecting the implant to the implant carrier;

s23, mounting the carrier with the implant on the converter;

s24, the upper cover connected with the implant is arranged back to the bottle body so that the implant is immersed in the autoblood.

Optionally, the centrifugation preparation step comprises:

s31, placing the fusion device filled with the implant soaked in the autoblood into a centrifuge for centrifugal separation to prepare the autoconcentrated growth factor.

Optionally, the fusing step comprises:

and S41, standing the fusion device for preparing the autologous concentrated growth factor to fully fuse the autologous growth factor with the surface of the implant and form an autologous surface on the implant.

Optionally, the autologous concentrated growth factor formed is CGF growth factor, and the standing time in step S41 is 5 min.

The invention provides a fusion device and a fusion method for the surface of an autologous concentrated growth factor implant, wherein a converter is arranged on the inner side of an upper cover of the fusion device, a connecting piece which can be in adaptive connection with a carrier of the implant is arranged in the converter, the implant can be arranged on the upper cover, and the implant can be immersed in autologous blood in the bottle when the upper cover is arranged back to the bottle; the fusion device was then placed on a centrifuge and the concentrated growth factors were centrifuged from the autologous blood. The implant is soaked in the concentrated growth factors in the fusion device, and the concentrated growth factors can be attached to the surface of the implant in a gap, so that a layer of more compatible and personalized autologous surface is formed, the fusion and reformation of the implant and bones are accelerated, any infection cannot be caused, the rejection reaction when foreign matters are implanted is reduced, the survival rate of the implant is increased, the healing is accelerated, and the success rate of the dental implant operation is greatly improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of an autologous concentrated growth factor implant surface fusion device provided in an embodiment of the present invention;

FIG. 2 is a schematic view of the connection structure of the upper cover and the converter;

FIG. 3 is a schematic view showing the positional relationship between the carrier and the upper cover and the implant;

FIG. 4 is a schematic view showing the state after the implant is placed in the fusion device and the concentrated growth factors are separated by a centrifuge;

FIG. 5 is a schematic structural diagram of another autologous concentrated growth factor implant surface fusion device provided in an embodiment of the present invention, in which an anti-collision member is disposed inside the bottle;

fig. 6 is a schematic view showing a state after the fusion device of fig. 5 is placed in an implant and centrifuged.

In the figure 1, a bottle body; 11. an accommodating cavity; 2. bottom sealing; 21. a first recess structure; 22. a second recessed structure; 3. an upper cover; 4. a converter; 5. a carrier; 6. an annular seal; 7. an implant; 8. an anti-collision member; 100. (ii) hemoglobin; 200. a CGF growth factor; 300. a serum protein.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

As shown in fig. 1, the present invention provides an autologous concentrated growth factor implant surface fusion device, which comprises a tubular bottle body 1, wherein two open ends of the bottle body 1 are respectively provided with a bottom seal 2 and an upper cover 3, and the bottom seal 2 is made of an elastic material; the upper cover 3 is detachably arranged on the bottle body 1, the inner side of the upper cover 3 is provided with a converter 4, the converter 4 is internally provided with a connecting piece, and the connecting piece can be in adaptive connection with the carrier 5 of the implant 7. The upper cover 3 can be screwed on the bottle body 1. The international universal standard screwdriver interface is internally provided with a converter 4 which can be butted with various carriers 5 to adapt to implants 7 of more brands. Fig. 3 shows a structure in a state where the carrier 5 is separated from the implant 7, and the carrier 5 is mounted to the upper cover 3 by the converter 4.

The inner side of the upper cover 3 of the fusion device is provided with a converter 4, the converter 4 can be matched and connected with a carrier 5 of the implant 7, the implant 7 can be arranged on the upper cover 3, and the implant 7 can be immersed in autologous blood in the bottle body 1 when the upper cover 3 is arranged back to the bottle body 1; the fusion device was then placed on a centrifuge and the concentrated growth factors were centrifuged from the autologous blood. As shown in fig. 4, the implant 7 is soaked in the concentrated growth factors in the fusion device, and the concentrated growth factors are attached to the gaps on the surface of the implant 7, so that a more compatible and personalized autologous surface is formed, the fusion and reformation of the implant 7 and bones are accelerated, no infection is caused, the rejection reaction during foreign body implantation is reduced, the survival rate of the implant 7 is increased, the healing is accelerated, and the success rate of dental implant surgery is greatly improved.

As an optional implementation mode, the converter 4 is sleeved with an annular sealing member 6, which can seal a gap between the converter 4 and the bottle body 1, and isolate the accommodating cavity 11 of the bottle body 1 from the outside to form vacuum, so that vacuum blood collection is realized, and the blood collection process is convenient and fast. The annular seal member 6 may be made of an elastic sealing material such as a rubber ring.

Alternatively, as shown in fig. 2, the converter 4 is integrally formed with the upper cover 3 or detachably engaged therewith. The converter 4 and the upper cover 3 are integrally formed, so that the number of parts is small, and the installation is quicker; the converter 4 and the upper cover 3 are detachably connected by means of clamping, and the converter 4 and the upper cover 3 can be replaced and maintained respectively.

As an alternative embodiment, the bottom seal 2 has a first concave structure 21 on a side close to the accommodating cavity 11 of the bottle body 1, so that a thinned design of the bottom seal 2 is realized.

As an optional embodiment, the side of the bottom seal 2 away from the accommodating cavity 11 of the bottle body 1 is provided with a second concave structure 22, so that on one hand, the bottom seal 2 is further thinned, the lancet is conveniently punctured, and the material is saved; on the other hand, the blood taking needle is limited and guided, and the blood taking needle can conveniently find a proper puncture point from the second concave structure 22 of the bottom seal 2.

As an optional implementation manner, the first recessed structure 21 and the second recessed structure 22 are both smooth transition curved surfaces, so that local thinning is realized under the condition that the structural strength is ensured, and the smooth transition curved surfaces are adopted, so that the processing is convenient; wherein the second concave structures 22 are all smooth transition curved surfaces and can prevent the needle from sliding everywhere during the needle insertion.

As an alternative embodiment, the bottom seal 2 is a rubber plug, which is tightly fitted to the bottle body 1, and after being filled, the rubber plug is tightly fitted and sealed with the bottle body 1 in an interference fit manner.

As an alternative embodiment, as shown in fig. 5, the inner wall of the bottle body 1 is provided with a bumper 8. The anti-collision piece 8 can prevent the collision between the implant 7 and the bottle body 1 in the centrifugal separation process, play a role in buffering, and also play a role in fixing to prevent the implant 7 from being separated. Fig. 6 shows a schematic view of the structure after the implant 7 is placed.

Specifically, the anti-collision member 8 is a circular ring structure, or a rod structure, or a support structure, and only some structures are illustrated herein, but not limited to the above-mentioned structures, as long as the implant 7 can not collide with the bottle body 1 when shaking relative to the bottle body 1.

The invention also provides a fusion method of the surface of the self-concentration growth factor implant, which adopts any one of the fusion devices to fuse the concentration growth factor with the surface of the implant 7; the method comprises a blood sampling step, an implant placing step, a centrifugal preparation step and a fusion step.

In one embodiment of the present invention, the surface fusion method of the autologous growth factor implant 7 comprises the following steps:

1. blood sampling step

(1) Preparing a fusion device;

(2) vacuum blood collection tube with built-in converter marked as fusion device

Labeling the vacuum blood collection tube with the name, the tooth position, the type of the implant, the collection time, the outpatient service or the number of hospitalization of the patient;

(3) disinfecting hands

Before blood sampling, operators wear the caps orderly, use soap or disinfectant and water to wash hands, and wear masks and gloves;

(4) selecting veins

Before blood sampling, the examinee is required to sit in front of the laboratory bench. Place the forearm on the bench with the palm facing up and place a pillow under the elbow. The bedridden subject requires the forearm to be extended to expose the puncture site. The common blood sampling position is the antecubital vein which is thick and easy to identify;

(5) pulse-pressing band

The pulse pressing belt is tied around the arm at a position of about 6cm above the blood sampling part, and the tail end of the pulse pressing belt is upward. The patient is asked to grip and release the fist several times, making the vein hump. The tourniquet should slow down distal venous blood return, but not be so tight as to constrict arterial blood flow.

(6) Disinfecting skin

Disinfecting the skin clockwise from the selected venipuncture site with a 30g/L iodine tincture cotton swab, and wiping off the iodine tincture with a 75% ethanol cotton swab in the same manner after the iodine tincture is volatilized, and drying.

(7) Puncturing skin

The sterile cap of the needle head is taken down, the lower end of the venipuncture part is fixed by the thumb of the left hand, and the lower seat of the needle head is fixed by the forefinger. Keeping the needle slope and the needle cylinder scale upward, obliquely penetrating the skin along the vein direction at an angle of 30 degrees by the needle and the skin, and then penetrating the vein wall forwards at an angle of 5 degrees to enter the vein cavity. And confirming the central position of the puncture into the vein, and pushing the needle head into the vein by 10-15 mm along the trend of the vein.

(8) Blood drawing

When the needle head enters the blood vessel, a small amount of blood returns, the blood taking needle is inserted into the vacuum blood taking tube with the built-in converter 4 from the bottom seal 2, the blood automatically flows into the blood taking tube due to the negative pressure effect in the blood taking tube, and the test tube is pulled out after reaching the blood taking volume scale. The fusion device may also be designed in a non-vacuum manner, requiring blood to be injected into the bottle 1 with a lancet.

(9) Hemostasis method

Order the examinee to relax his fist, press the needle insertion part with a sterilized cotton swab, and pull out the needle rapidly backward. Continue to hold down the sterilized cotton swab for 3 min.

2. Implant placing step

Unscrewing the upper cover 3, taking out a machine carrier 5 (a machine implant implantation screwdriver) of a corresponding brand, connecting an implant 7, and installing the carrier 5 of the butted implant 7 on the converter 4; then the upper cover 3 is screwed back to the bottle body 1, so that the implant 7 is immersed in the autoblood, and then the fusion device is placed in a centrifuge, and the corresponding procedure is selected for preparation.

3. Preparation by centrifugation

The sterile vacuum blood collection tube filled with the implant 7 is placed in a centrifuge, and the corresponding program is selected for preparation.

CGF (concentrated Growth Factors, fibrin with highly concentrated Growth Factors) is an autologous blood concentrated product rich in Growth Factors with higher concentration and CD34+ cells, which is produced by fully activating alpha particles in platelets by means of physical acceleration and deceleration by using a special variable speed centrifuge and shows better regeneration capability of bone tissues, soft tissues and skin. The blood was separated by centrifugation into hemoglobin 100 at the bottom layer, CGF growth factor 200 at the middle layer, and serum protein 300 at the top layer.

The implant 7 is implanted with insufficient cooling of the prepared hole or excessive implantation torque, which leads to the necrosis of bone cells and thus the failure of dental implant surgery. After the CGF growth factor is adopted for soaking, the bone injury caused by the operation can be finally promoted to heal and regenerate the tissue by guiding revascularization of the injured tissue, immunoregulation and capturing stem cells in circulating blood.

4. Fusion

After the preparation is finished, the CGF growth factor is kept stand for 5 minutes and is fully fused on the surface of the implant 7.

And after the fusion is finished, the implant 7 soaked in the CGF is taken out, and the corresponding tooth position is selected for implantation.

The invention integrates the advantages of clinical application of platelets with the rapid osseointegration and reduction of rejection reactions that need to be solved by implant surface treatment.

In the description of the invention, it is to be noted that "a plurality" means two or more unless otherwise specified; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing and simplifying the description, but do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated, and thus are not to be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood as appropriate to those of ordinary skill in the art.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The device for fusing the surface of the autologous concentrated growth factor implant is characterized by comprising a tubular bottle body (1), wherein two open ends of the bottle body (1) are respectively provided with a bottom seal (2) and an upper cover (3), and the bottom seal (2) is made of an elastic material; the upper cover (3) is detachably arranged on the bottle body (1), a converter (4) is arranged on the inner side of the upper cover (3), and the converter (4) can be in adaptive connection with a carrier (5) of the implant (7).

2. The self-concentrating growth factor implant surface fusion device according to claim 1, wherein the converter (4) is sleeved with an annular sealing member (6) capable of closing a gap between the converter (4) and the bottle body (1).

3. The autologous concentrated growth factor implant surface fusion device according to claim 1, wherein the converter (4) is integrally formed with the upper cover (3) or detachably connected by snap fit.

4. The self-concentrating growth factor implant surface fusion device according to claim 1, wherein a side of the bottom seal (2) close to the accommodating cavity (11) of the bottle body (1) is provided with a first concave structure (21).

5. The self-concentrating growth factor implant surface fusion device according to claim 4, wherein the bottom seal (2) has a second concave structure (22) on a side away from the accommodating cavity (11) of the bottle body (1).

6. The autologous concentrated growth factor implant surface fusion device according to claim 5, wherein the first recessed structure (21) and the second recessed structure (22) are both rounded transition surfaces.

7. The self-concentrating growth factor implant surface fusion device according to claim 1, wherein the bottom seal (2) is a rubber plug which is tightly fitted to the bottle body (1).

8. The self-concentrating growth factor implant surface fusion device according to claim 1, wherein the inner wall of the bottle body (1) is provided with an anti-collision member (8).

9. A fusion method of autologous concentrated growth factor implant surface, characterized in that the fusion device of any one of claims 1-8 is used to perform the fusion of concentrated growth factor with the implant (7) surface; the method comprises a blood sampling step, an implant placing step, a centrifugal preparation step and a fusion step.

10. The autologous concentrated growth factor implant surface fusion method according to claim 9, wherein the blood collection step comprises:

s11, extracting autologous blood of the patient;

s12, injecting the collected blood into the containing cavity (11) of the bottle body (1).

11. The method for fusing the surface of the autologous concentrated growth factor implant according to claim 10, wherein a blood collection needle is inserted into the bottom seal (2) to inject or suck blood into the bottle body (1) in step S12.

12. The method for fusing the surface of the autologous concentrated growth factor implant according to claim 10, wherein the implant placement step comprises:

s21, separating the upper cover (3) from the bottle body (1);

s22, connecting the implant (7) to the carrier (5);

s23, mounting the carrier (5) with the implant (7) on the converter (4);

s24, the upper cover (3) connected with the implant (7) is arranged back to the bottle body so that the implant (7) is immersed in autologous blood.

13. The method for autologous concentrated growth factor implant surface fusion according to claim 12, wherein the step of preparing by centrifugation comprises:

s31, placing the fusion device with the implant (7) immersed in the autoblood into a centrifuge for centrifugal separation to prepare the autoconcentrated growth factor.

14. The method for fusing the autologous concentrated growth factor implant surface according to claim 13, wherein the fusing step comprises:

s41, standing the fusion device for preparing the autologous concentrated growth factor to ensure that the autologous concentrated growth factor is fully fused with the surface of the implant (7) and an autologous surface is formed on the implant (7).

15. The method for fusing the surface of the autologous concentrated growth factor implant according to claim 14, wherein the formed autologous concentrated growth factor is CGF growth factor, and the standing time in step S41 is 5 min.