CN112168286B

CN112168286B - Bolt taking support, bolt taking device and bolt taking system

Info

Publication number: CN112168286B
Application number: CN202011281597.3A
Authority: CN
Inventors: 王永胜; 程舒宇; 于鹏
Original assignee: Hangzhou Deno Brain Neurology Medical Technology Co ltd
Current assignee: Hangzhou Deno Brain Neurology Medical Technology Co ltd
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2024-06-28
Anticipated expiration: 2040-11-16
Also published as: CN112168286A

Abstract

The invention relates to a thrombus taking support, a thrombus taking device and a thrombus taking system, wherein the thrombus taking support comprises rigid units and flexible units which are arranged in a linear manner and are alternately connected; the rigid unit and the flexible unit are in a tubular structure which can be compressed and expanded in radial direction; the flexible unit is more susceptible to bending and deformation than the rigid unit when subjected to an equivalent radial force. The invention uses the rigid units and the flexible units of the tubular structure to be alternately connected to form the integral bracket, wherein the rigid units have supporting function, can cut and catch thrombus when being naturally unfolded, and quickly establish a blood flow channel to realize the pre-communication of the blood flow channel. The flexible unit is utilized to carry out radial bending, so that the whole thrombus taking support can be bent at the position of the flexible unit, the flexibility of the thrombus taking support is improved, the capability of the thrombus taking support to pass through a bent roundabout blood vessel when the thrombus taking support is pulled back after catching thrombus is improved, the thrombus taking support is ensured to be always attached to the blood vessel wall, the thrombus is prevented from falling off, and finally the capability of capturing thrombus is improved.

Description

Bolt taking support, bolt taking device and bolt taking system

Technical Field

The invention relates to the technical field of medical equipment, in particular to a thrombus taking support, a thrombus taking device and a thrombus taking system.

Background

Thrombus is a blood clot formed by abnormal aggregation of components such as platelets in blood in circulating blood, and the blood clot or the blood clot occurs on the inner wall or wall of the heart, which causes vascular obstruction or embolism, and secondary serious body injury. Thrombosis is spread over the whole cardiovascular system and affects whole body tissue organs, and is not limited to myocardial infarction, deep venous thrombosis or cerebral thrombosis and other lesions, and thrombosis can occur in blood vessels at any part in the body. The occurrence rate of venous thrombosis is higher than that of arterial thrombosis, the ratio of the venous thrombosis to the arterial thrombosis is up to 4:1, the venous thrombosis accounts for 40% -60% of the thrombus mechanism, the occurrence rate of the occlusive coronary thrombosis is 15% -95%, and 90% of the thrombosis is accompanied with atherosclerosis plaques. Thrombosis causes vascular occlusion, blood flow obstruction, ischemia, hypoxia and even necrosis of relevant vascular control tissues, and symptoms of dysfunction of corresponding tissues and organs are generated.

At present, anticoagulant medicaments and thrombolytic medicaments are mostly used for treatment clinically, but the treatment effect is extremely unobvious, the larger the diameter of a blood vessel blocked by thrombus is, the worse the treatment effect is, the blood vessel recanalization rate is low, the recanalization time is long, and some patients are not suitable for thrombolytic treatment.

At present, some mechanical devices are adopted for thrombus removal, a novel and efficient vascular recanalization treatment method is provided for thrombus patients, the mechanical thrombus removal operation time is short, related complications are few, and the method is a research hot spot in the current thrombus treatment field; according to the shape and function realization form of the main flow interventional thrombus taking device, the main flow interventional thrombus taking device can be divided into: spiral, screen, brush, suction, stent. A common drawback of these mainstream products is that there is a residue after removal of the thrombus and that the thrombus falls off during withdrawal, resulting in an unsatisfactory performance of the thrombus capture device as a whole. The nerve thrombosis takes internal carotid artery, middle cerebral artery, vertebral artery and basilar artery as good sites, the acute thrombosis is mostly in a greasy and smooth state, and the existing metal thrombus taking stent is difficult to catch completely.

Disclosure of Invention

An object of the present invention is to provide a thrombus-taking stent, so as to optimize the structure of the thrombus-taking stent in the thrombus-taking device in the prior art and improve the thrombus capturing performance of the thrombus-taking stent.

Another object of the present invention is to provide a thrombus removing device, so as to optimize the structure of the thrombus removing device in the prior art and improve the performance of capturing thrombus of the thrombus removing device.

It is a further object of the present invention to provide a thrombus removal system that optimizes the structure of the prior art thrombus removal system and improves the thrombus capturing performance of the thrombus removal system.

In order to solve the technical problems, the invention adopts the following technical scheme:

according to one aspect of the present invention, there is provided a thrombolytic stent comprising rigid units and flexible units arranged in a linear pattern and alternately connected; the rigid unit and the flexible unit are both in a radially compressible and expandable tubular structure; the flexible unit is more easily bent and deformed than the rigid unit when subjected to an equal radial force, so that the thrombolytic stent can be bent at the flexible unit.

According to some embodiments of the application, the maximum radial dimension of the flexible unit is greater than the radial dimension of the rigid unit in the natural expanded state.

According to some embodiments of the application, the outer peripheral walls of the rigid unit and the flexible unit are both mesh structures.

According to some embodiments of the application, the flexible unit comprises a connector and a wave ring which are correspondingly connected in an axial direction; the connecting piece is positioned at the far end side of the wavy circle; each wave-shaped ring is provided with staggered wave crests and wave troughs along the circumferential direction; and partial wave crests of the wavy ring are connected with the proximal end of the connecting piece, and the partial wave crests of the wavy ring are suspended.

According to some embodiments of the application, in the wave ring, the wave crest which is correspondingly connected with the connecting piece and the wave crest which is suspended are arranged at staggered intervals.

According to some embodiments of the application, the connecting piece comprises a plurality of V-shaped rods which are circumferentially arranged at intervals, wherein the V-shaped rods are rod pieces bent in a V shape; the vertex of the V-shaped rod is a proximal end and is connected with the wave crest of the wave ring; the two ends of the V-shaped rod opposite to the vertex of the V-shaped rod are distal ends, and the two distal ends of the V-shaped rod are used for being connected with the rigid unit or connected with the trough of another wave-shaped ring.

According to some embodiments of the application, the flexible unit is easier to axially compress than the rigid unit when subjected to an equal axial force; and the radial dimensions of the flexible unit increase simultaneously as it compresses axially.

According to some embodiments of the application, the flexible unit comprises a plurality of spiral rods wound in the same direction in a spiral manner, and the plurality of spiral rods are arranged at intervals in the circumferential direction; the two ends of the screw rod are respectively connected with one rigid unit.

According to some embodiments of the application, the winding angle from one end of the screw to the other end of the screw is in the range of 0-360 °.

According to some embodiments of the application, the screw rod comprises a first winding section and a second winding section which are connected at one end, wherein the first winding section and the second winding section are both spirally wound; in a natural expansion state, the distance from the first winding section to the central axis of the flexible unit gradually becomes smaller in the direction gradually away from the second winding section; the second winding section gradually becomes smaller in distance from the central axis of the flexible unit in a direction gradually away from the first winding section; the connection part of the first winding section and the second winding section is the outermost side of the flexible unit in the radial direction.

According to some embodiments of the application, the thrombus removal support further comprises a connecting arm, wherein the rigid unit and the flexible unit are connected through the connecting arm, and the connecting arm is in a rod shape.

According to some embodiments of the application, the connecting arms are provided in plurality, the plurality of connecting arms being distributed along the circumference of the rigid unit.

According to some embodiments of the application, the proximal and distal most ends of the thrombolytic stent are both the rigid units.

According to some embodiments of the application, the maximum radial dimension of the plurality of flexible units in the thrombolytic stent sequentially increases in a proximal-to-distal direction in a naturally expanded state.

According to some embodiments of the application, for a set of rigid units disposed between two adjacent flexible units, the axial length of a plurality of the rigid units in the set decreases in sequence in a direction from the proximal end to the distal end of the thrombolytic stent.

According to some embodiments of the application, for a set of rigid units disposed between two adjacent ones of the flexible units, the radial dimension of each of the rigid units in the set becomes progressively larger in a proximal-to-distal direction.

According to another aspect of the invention, the invention also provides a thrombus removing device, which comprises the thrombus removing bracket and a traction guide wire connected with the thrombus removing bracket.

According to some embodiments of the application, the thrombolytic device further comprises a distal tube and a proximal tube; the most distal end of the thrombus taking support is connected to the distal tube in a converging way; the nearest end of the thrombus taking support is converged and connected to the proximal tube.

According to some embodiments of the application, the distal end of the pull wire is connected to the proximal tube.

According to some embodiments of the application, the proximal tube is a hollow tube; the traction guide wire passes through the proximal tube and sequentially passes through the rigid unit and the flexible unit, and the distal end of the traction guide wire is connected with the distal tube.

According to some embodiments of the application, the distal tube is a hollow tube, and the distal end of the traction guidewire passes out of the distal tube and is clamped at the distal end of the distal tube.

According to some embodiments of the application, the traction guide wire is provided with a heating part, and the heating part is correspondingly arranged in the rigid unit or the flexible unit; the traction guidewire may be electrically connected to an external power source; in the energized state, the heat generating portion can generate heat.

According to yet another aspect of the present invention, there is also provided a thrombolysis system comprising the above-described thrombolysis device, a pushrod, a loading sheath and a microcatheter; the push rod is connected with the proximal end of the thrombus taking support and is used for pushing and pulling the thrombus taking support; the loading sheath is used for accommodating the thrombus taking device in a compressed state; the microcatheter is used for communicating with the loading sheath, and a lumen in the microcatheter is used for conveying the thrombus taking device.

As can be seen from the technical scheme, the embodiment of the invention has at least the following advantages and positive effects:

In the thrombus taking support, a plurality of rigid units and flexible units are utilized to form a thrombus taking support structure which is sequentially and alternately connected in a straight line. Wherein, the rigid units have rigid effect, and the plurality of rigid units can play the role of framework support; when the thrombus is naturally unfolded, the tubular structure of the rigid unit can cut and catch the thrombus, and a blood flow channel is quickly established, so that the pre-communication function of the blood flow channel is realized.

The flexible unit is more flexible than the rigid unit, can radially bend, and then enables the whole thrombus taking support to bend at the position of the flexible unit, so that the flexibility of the thrombus taking support is improved, the capability of the thrombus taking support to pass through a bent roundabout blood vessel when being pulled back after catching thrombus can be improved, the thrombus taking support is ensured to be always attached to the blood vessel wall, the thrombus is prevented from falling off, and finally the thrombus capturing performance of the thrombus taking support is improved.

Drawings

Fig. 1 is a schematic view of the structure of a first embodiment of the thrombolysis device of the present invention.

Fig. 2 is a schematic view of the thrombolytic device shown in fig. 1 in a radially bent state.

Fig. 3 is a schematic view of the thrombolytic device of fig. 1 in an axially compressed state.

Fig. 4 is a schematic view of the thrombolytic device of fig. 1 prior to assembly and use.

Fig. 5 is a schematic view of the thrombolytic device of fig. 4 in assembled use.

Fig. 6 is a schematic view showing the thrombolytic device of fig. 5 in a pushed state in a microcatheter.

Fig. 7 is a schematic view of a first state of the thrombus removal process of the thrombus removal device shown in fig. 1.

Fig. 8 is a schematic view showing a second state of the thrombus removing process of the thrombus removing device shown in fig. 1.

Fig. 9 is a schematic view showing a third state of the thrombus removing process of the thrombus removing device shown in fig. 1.

Fig. 10 is a schematic view showing a fourth state of the thrombus removal process of the thrombus removal device shown in fig. 1.

Fig. 11 is a schematic view showing a fifth state of the thrombus removing process of the thrombus removing device shown in fig. 1.

Fig. 12 is a schematic view showing a sixth state of the thrombus removing process of the thrombus removing device shown in fig. 1.

Fig. 13 is a schematic view of a prior art thrombolytic stent passing through a tortuous vessel.

Fig. 14 is a schematic view of the thrombolytic stent shown in fig. 1 passing through a tortuous vessel.

Fig. 15 is a schematic view of the structure of a second embodiment of the thrombolytic device of the present invention.

Fig. 16 is a schematic view of the structure of a third embodiment of the thrombolytic device of the present invention.

Fig. 17 is a schematic view of the structure of a fourth embodiment of the thrombolytic device of the present invention.

Fig. 18 is a schematic view showing the structure of a fifth embodiment of the thrombus removing device of the present invention.

Fig. 19 is a schematic view showing the structure of a sixth embodiment of the thrombus removing device of the present invention.

Fig. 20 is a schematic view showing the structure of a seventh embodiment of the thrombus removing device of the present invention.

Fig. 21 is a side view of the flexible unit shown in fig. 20.

Fig. 22 is another structural schematic view of the flexible unit shown in fig. 20.

Fig. 23 is a schematic view of still another construction of the flexible unit shown in fig. 20.

Fig. 24 is a schematic view of the thrombolytic device of fig. 20 in a radially curved state.

Fig. 25 is a schematic view showing the structure of an eighth embodiment of the thrombus removing device of the present invention.

Fig. 26 is a schematic view of the traction wire shown in fig. 25.

Fig. 27 is a schematic view showing the structure of a ninth embodiment of the thrombus removing device of the present invention.

The reference numerals are explained as follows:

100/100a/100b/100c/100d/100e/100f/100g/100h, and a thrombus removal device; 200. a push rod; 300. loading a sheath; 400. a microcatheter; 500. a sheath; 600. a joint member; 700. perforating a guidewire;

1/1a/1b/1c/1e/1d/1f/1g/1h, and a thrombus taking bracket; 11/11a/11b/11d, rigid units; 111. a first wavy circle; 1111. a peak; 1112. a trough; 12/12c/12d/12e/12f, flexible unit; 121/121e, struts; 1211. a first winding section; 1212. a second winding section; 1211e, a first arcuate segment; 1212e, a second arcuate segment; 122. a second wavy circle; 1221. a peak; 1222. a trough; 123. a connecting piece; 124. an annular ring; 13. a connecting arm; 14. a proximal tube; 15. a distal tube; 16. a connecting rod;

2/2f/2g/2h, traction guidewire; 201. a limit part; 21/21h, a guide wire core; 22/22h, heating part; 23. an insulating layer; 24. an elastic part.

Detailed Description

Exemplary embodiments that embody features and advantages of the present invention will be described in detail in the following description. It will be understood that the invention is capable of various modifications in various embodiments, all without departing from the scope of the invention, and that the description and illustrations herein are intended to be by way of illustration only and not to be construed as limiting the invention.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features. In the description of the present application, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.

The thrombus taking bracket and the thrombus taking device provided by the embodiment of the invention are used for dredging the blocked blood vessel and catching thrombus in the blocked blood vessel when the blood vessel is blocked. The thrombus taking device comprises a thrombus taking bracket and a traction guide wire, wherein the traction guide wire is connected with the thrombus taking bracket and can be arranged in the thrombus taking bracket in a penetrating way. The thrombus taking support has radial telescopic performance, so that a collapsed state and a natural expansion state are formed between the thrombus taking supports. In the collapsed state, the thrombus-taking stent can be conveniently delivered in a blood vessel through a microcatheter and delivered to a lesion site. When the thrombus reaches the lesion site, the microcatheter is withdrawn, so that the thrombus taking stent can recover to a natural expansion state, further the thrombus at the lesion site is cut and captured, and finally the captured thrombus is withdrawn, thereby realizing dredging of the blocked blood vessel.

For ease of description and understanding, the term "proximal" as defined herein refers to the end proximal to the operator and the term "distal" refers to the end distal from the operator.

Several embodiments of the thrombolytic device are described in detail below.

The first embodiment is described with reference to the structure and use state shown in fig. 1 to 3.

Referring first to fig. 1, a thrombectomy device 100 of the present embodiment includes a thrombectomy stent 1 and a traction guidewire 2.

Wherein, the thrombus taking support 1 is in a hollow tubular structure, the peripheral wall of the thrombus taking support can be in a grid or mesh structure, and the grid or mesh structure can be in an irregular hole-shaped structure. The traction guide wire 2 passes through the proximal end of the thrombus taking support 1 and stretches into the thrombus taking support 1, and the distal end of the traction guide wire 2 is connected with the distal end of the thrombus taking support 1. The proximal end of the traction guide wire 2 can be connected with the outside, and the traction guide wire 2 moves towards the proximal end of the blood vessel to drive the thrombus taking support 1 to retract towards the proximal end of the blood vessel.

The thrombolytic stent 1 has a collapsed state and a natural expanded state. In the collapsed state, the radial dimension of the thrombolytic stent 1 is minimized, which facilitates delivery within the blood vessel, and the thrombolytic stent 1 is delivered to the lesion.

The thrombus taking support 1 can be made of memory metal, and when no external pressure exists in the radial direction, the thrombus taking support 1 expands automatically, and the radial dimension becomes larger. In the natural expansion state, the thrombus taking stent 1 expands the thrombus at the lesion site and cuts the thrombus by using a mesh or a mesh structure on the outer peripheral wall thereof, so that the thrombus enters the thrombus taking stent 1 and is captured by the thrombus taking stent 1. Along with the motion of the traction guide wire 2 to the proximal end of the blood vessel, the thrombus taking bracket 1 can be controlled to drive the thrombus captured in the thrombus taking bracket to retract so as to dredge the blocked blood vessel.

The embolectomy stent 1 of this embodiment comprises a rigid unit 11, a flexible unit 12, a connecting arm 13, a proximal tube 14 and a distal tube 15.

The rigid units 11 and the flexible units 12 are arranged in a linear manner and are alternately connected, and the rigid units 11 and the flexible units 12 are connected through connecting arms 13. The most proximal and the most distal end of the thrombolytic stent 1 are rigid units 11. The rigid units 11 have a rigid effect, and a plurality of the rigid units 11 can play a role of skeleton support. The rigid units 11 are arranged at the head and the tail, so that the supporting performance and the propelling performance of the thrombus taking support 1 can be improved. The flexible unit 12 has flexibility and can be folded and compressed. The rigid unit 11 and the flexible unit 12 are in a radially telescopic tubular structure, and the rigid unit 11 and the flexible unit 12 can be communicated with each other. The peripheral wall of the rigid unit 11 is in a grid or mesh structure, and the peripheral wall of the flexible unit 12 is provided with an opening for communicating the inside and the outside of the tubular structure of the flexible unit 12, or the peripheral wall of the flexible unit 12 is provided with meshes, so that when the rigid unit 11 and the flexible unit 12 are unfolded, thrombus around the rigid unit 11 and the flexible unit 12 can be cut, and the cut portion of the thrombus enters the tubular structure and is captured by the rigid unit 11 or the flexible unit 12.

The rigid unit 11 of the present embodiment has a strong rigidity effect, and itself has a large radial supporting force. In the natural expanded state, the rigid unit 11 has a smaller diameter than the vessel and the flexible unit 12. Therefore, when the rigid unit 11 is unfolded, the blood vessel is not wounded, and a blood flow channel can be quickly established, so that the pre-ventilation function of blocking the blood flow channel at the blood vessel is realized.

Referring to fig. 1, the rigid unit 11 in the present embodiment is a grid unit, and the grid unit has a network management structure.

Further, the grid cell of the present embodiment mainly includes a plurality of first wavy turns 111 axially connected. Each first spider 111 has circumferentially alternating peaks 1111 and valleys 1112. With peaks 1111 facing distally and valleys 1112 facing proximally. The peaks 1111 of the proximal first wave ring 111 are correspondingly connected with the valleys 1112 of the distal first wave ring 111 to form a grid structure.

In particular, as shown in fig. 1, the rigid unit 11 has two first wavy turns 111, and each first wavy turn 111 can be regarded as a closed loop structure formed by continuously bending and extending the rod in a Z shape or a W shape. The valleys 1112 of the first undulating ring 111 at the proximal end are connected to the connecting arms 13 or are connected together to the proximal tube 14. The peaks 1111 of the first wavy collar 111 at the distal end are connected to the connecting arm 13 or are connected to the distal tube 15 in a converging manner. The grid structure between two adjacent first wavy rings 111 is a diamond grid, and other grids can be formed, such as triangle, rectangle or polygon.

The first wavy turns 111 and the whole rigid unit 11 are capable of extending and contracting in the radial direction, so that adjacent peaks 1111 and adjacent valleys 1112 between the first wavy turns 111 can be close to or far from each other. Upon natural expansion, the diameter of the first wave ring 111 becomes large, and the axial interval between the peaks 1111 and the valleys 1112 becomes small, while the circumferential interval becomes large. When the thrombus taking support 1 reaches the thrombus of the lesion part, the rigid unit 11 is expanded through the self-expansion of the first waveform ring 111, so that the thrombus can be spread, a blood flow channel is established, and a pre-communication function is realized; and the thrombus is cut through the first wavy circle 111, and the cut thrombus portion enters the first wavy circle 111 and is captured by the grid cells.

In the present embodiment, the flexible unit 12 is more flexible than the rigid unit 11.

Referring to fig. 2, when receiving the same radial force, the flexible unit 12 of the present embodiment is easier to bend and deform than the rigid unit 11, so that the thrombus taking support 1 can bend at the flexible unit 12, thereby ensuring the effect of capturing thrombus by the thrombus taking support 1, and simultaneously taking into account the overall flexibility of the thrombus taking support 1, so that the thrombus taking support 1 can be delivered and retracted in a roundabout blood vessel.

Referring to fig. 3, the flexible unit 12 of the present embodiment is easier to axially compress than the rigid unit 11 when subjected to the same axial force; and the maximum radial dimension D1 thereof increases simultaneously when the flexible unit 12 is axially compressed.

In the natural expanded state, the maximum radial dimension D1 of the flexible unit 12 is greater than the maximum radial dimension D2 of the rigid unit 11. A space 10 may be formed between two adjacent flexible units 12, and thrombus located in the space 10 is distributed on the peripheral side of the corresponding rigid unit 11 without being cut by the lattice structure of the rigid unit 11, thus maintaining its integrity.

In the process of withdrawing the thrombus taking support 1, the flexible unit 12 can push complete thrombus in the interval space 10 to withdraw, so that the risk of falling off the thrombus is reduced, and the success rate of thrombus taking out is further improved. Meanwhile, since the uncut thrombus is mainly confined in the space 10, the thrombus-taking stand 1 exerts a force on the thrombus substantially in a direction parallel to the blood vessel upon withdrawal, which means that the thrombus-taking stand 1 does not act on the thrombus to increase the force required for removing the thrombus from the blood vessel, so that the vulnerable blood vessel (e.g., cerebral blood vessel) can be protected from harmful radial force and tensile force.

If the maximum radial dimension D1 of the flexible unit 12 is smaller than the maximum radial dimension D2 of the rigid units 11, the space 10 is formed between the two adjacent rigid units 11, and when the thrombus-removing stent 1 is retracted and passes through a curved blood vessel, the flexible unit 12 is bent to protrude to one side, so that thrombus in the space 10 between the two rigid units 11 is squeezed out of the space 10, which is disadvantageous for catching and retraction of thrombus, as shown in fig. 13 and 14. A solution is chosen in which the maximum radial dimension D1 of the flexible unit 12 is greater than the maximum radial dimension D2 of the rigid unit 11.

It should be noted that, in the natural expansion state, the maximum radial dimension D1 of the flexible unit 12 may be smaller than the maximum radial dimension D2 of the rigid unit 11, and the space 10 may be formed between adjacent flexible units 12 only by axially compressing the flexible unit 12 and then making the maximum radial dimension D1 larger than the maximum radial dimension D2 of the rigid unit 11.

Still referring to fig. 3, when the thrombus taking stand 1 is acted by the pressing forces at the opposite ends in the axial direction, the maximum radial dimension D1 of the flexible unit 12 of the present embodiment becomes larger, and the axial dimension becomes smaller; while the maximum radial dimension D2 and the axial dimension of the rigid unit 11 remain unchanged. Therefore, based on the variable feature of the maximum radial dimension D1 of the flexible unit 12, when the thrombus taking stent 1 is retracted from the distal end of the blood vessel to the proximal end of the blood vessel, if the diameter of the blood vessel is gradually increased, the flexible unit 12 of the thrombus taking stent 1 can be kept in an adherent state all the time in different blood vessel segments by adjusting the maximum radial dimension D1 of the flexible unit 12, so that the thrombus inside the thrombus taking stent 1 and the large thrombus in the interval space 10 can be taken out during retraction, further the effect and the success rate of thrombus taking out are improved, and the risk of thrombus falling off is reduced.

In addition, the thrombus-taking support 1 formed by the rigid units 11 and the flexible units 12 alternately is of a sectional structure, when the thrombus-taking support 1 catches thrombus to retract to the guide catheter or the middle catheter, the proximal structure of the thrombus-taking support 1 is compressed due to entering the guide catheter or the middle catheter, and the change of the rear structure can not be caused, so that the thrombus falling caused by the integral compression of the thrombus-taking support 1 during retraction can be avoided.

The flexible unit 12 in this embodiment includes a plurality of struts 121, and the plurality of struts 121 are circumferentially spaced apart to form a cylindrical structure. The spatial spacing between adjacent struts 121 forms openings or mesh openings in the peripheral wall of the flexible unit 12; both ends of the supporting rod 121 are respectively connected with a connecting arm 13. The ends of adjacent struts 121 may be spaced apart such that the spatial spacing between adjacent struts 121 is evenly distributed. The ends of adjacent struts 121 are also partially joined for connection to the connecting arms 13. Each strut 121 is able to expand radially outwardly as the flexible unit 12 is axially compressed to progressively increase the radial dimension of the flexible unit 12.

Referring to fig. 1 specifically, the struts 121 in the present embodiment are spiral rods, and the plurality of struts 121 are spirally wound clockwise or counterclockwise along the same direction, so that the flexible unit 12 forms a spiral unit. A screw is understood to be a wire-like or rod-like structure and is wound in a spiral, with the spacing between adjacent screws forming openings or meshes in the peripheral wall of the flexible unit 12. The proximal to distal spiral turns of the spiral rod are not more than 360 degrees, wherein the greater the turns, the better the compliance and the weaker the support.

The screw rod may be divided into a first winding section 1211 and a second winding section 1212 according to the distance from the screw rod to the center line of the screw unit, and the first winding section 1211 and the second winding section 1212 may be connected at one end and spirally wound in the same direction. The junction of the first and second winding segments 1211, 1212 is the radially outermost side of the flexible unit 12. The first winding section 1211 gradually becomes smaller in distance from the central axis of the flexible unit 12 in a direction gradually away from the second winding section 1212. The second winding section 1212 becomes progressively smaller in distance from the central axis of the flexible unit 12 in a direction progressively farther from the first winding section 1211.

The spiral unit not only can bend under the action of radial pressure; axial compression can also be performed under axial pressure. When axially compressed, the spiral units synchronously expand radially to fully attach to the vessel wall and fully contact with thrombus, so that the maximum embedding effect is realized. At the same time the expanded flexible element 12 has a larger diameter than the rigid element 11, so that the rigid element 11 is not in contact with the vessel wall.

In this embodiment, the flexible units 12 forming the spiral units and the rigid units 11 forming the grid units are sequentially arranged at intervals and alternately, so that the thrombus taking support 1 integrally forms a segmented structure, the flexibility of the thrombus taking support 1 is improved, and the thrombus taking support can adapt to blood vessels with different bending forms. The grid structure of the rigid unit 11 embedded with thrombus can open the inside of the thrombus through the radial supporting force of the grid structure, so that a blood flow channel is quickly established, and the pre-communication function of blocking blood vessels in real time is realized; the lattice structure of the rigid units 11 also enables the formation of a catching structure that cuts and catches thrombus when deployed. The spiral unit is of a flexible structure and is in a compressed state when the inside of thrombus is unfolded. At this time, external force compression is utilized, and the guide wire 2 is pulled to retract towards the proximal end relative to the thrombus taking support 1, so that the spiral unit is fully expanded, the spiral rod cuts thrombus, and the spiral unit is embedded with the thrombus to the greatest extent and is attached to the vessel wall. The spiral cells in the expanded state have a larger diameter than the mesh cells, with adjacent spiral cells forming a space 10 therebetween. Thrombus in the space 10 which is not cut by the grid cells can maintain high integrity, and the risk of falling off of thrombus can be reduced in the retracting process, so that the effect and success rate of thrombus extraction are improved.

In this embodiment, both the spiral cells and the mesh cells may be fabricated from memory alloys or polymeric materials. Specifically, the nickel-titanium alloy pipe can be formed by knitting or laser cutting nickel-titanium pipe, can be formed by crimping and heat setting after laser cutting nickel-titanium plate, can be formed by knitting nickel-titanium wire, can be formed by processing elastic plastic material, and the like.

As shown in fig. 1 in particular, the thrombus-taking stand 1 of the present embodiment is sequentially and alternately connected by four rigid units 11 and three flexible units 12. The number of the rigid units 11 and the flexible units 12 is not limited, and may be increased accordingly, and may be designed as needed.

The rigid unit 11 and the flexible unit 12 are connected by a connecting arm 13. One end of the connecting arm 13 is connected to the rigid unit 11, and the other end is connected to the flexible unit 12. The connecting arm 13 may be parallel to the central axis of the thrombolytic stent 1, and the connecting arm 13 may have a rod shape and extend in the axial direction of the thrombolytic stent 1. The connecting arm 13 may also be a curved or helical spiral arm. The use of the connecting arms 13 allows a better transition between the rigid units 11 and the flexible units 12 to allow bending between adjacent rigid units 11 in the thrombolytic stent 1 without compromising the expansibility of the flexible units 12 as much as possible and maintaining the ability of the flexible units 12 to align and adhere well to the vessel wall.

Specifically, one end of the connection arm 13 may be connected to the crest 1111 or the trough 1112 of the first wave ring 111 in the grid unit, and the other end of the connection arm 13 may be connected to one end of one or more screw rods in the screw unit. Between adjacent rigid units 11 and flexible units 12, a plurality of connecting arms 13 may be provided. The plurality of connection arms 13 are arranged at intervals around the axial direction of the rigid unit 11. In the embodiment, as shown in fig. 1, four connecting arms 13 are provided, and one end of each connecting arm 13 is connected to a screw rod, and the other end is connected to a crest 1111 or a trough 1112 of the first wave ring 111.

On the embolectomy stent 1, the proximal end of the proximal-most rigid unit 11 is of conical configuration and is connected in a converging manner to the proximal tube 14. By adopting the conical structure, the overall flexibility of the proximal structure of the thrombus taking support 1 can be improved, and the thrombus taking support 1 can conveniently enter the guide catheter or the sheath 500 when being retracted.

On the embolectomy stent 1, the distal end of the most distally located rigid unit 11 is of conical configuration and is convergently connected to the distal tube 15. The distal end of the most distal rigid unit 11 is in a conical structure, so that the damage to thrombus during the advancing process of the thrombus taking support 1 can be reduced, and the risk of breaking the thrombus to flow to the distal end of a blood vessel can be reduced.

In this embodiment, the proximal tube 14 is a hollow tube, and the guiding wire 2 is pulled to pass through the proximal tube 14 and sequentially pass through the rigid unit 11 and the flexible unit 12; the distal end of the traction wire 2 is connected to a distal tube 15.

The distal tube 15 may also be a hollow tube, and the distal end of the traction guidewire 2 is provided with a limiting portion 201, and the limiting portion 201 may be in a spherical structure. After the distal end of the traction wire 2 passes through the distal tube 15 of the hollow structure, the distal end of the distal tube 15 is clamped by the limiting part 201. When the traction guide wire 2 is retracted, the traction guide wire 2 can drive the thrombus taking support 1 to retract. It will be appreciated that the distal end of the pull wire 2 may also be welded to the distal tube 15.

Referring to fig. 4 to 6, the thrombus removal device 100 according to the embodiment of the present invention is loaded in a collapsed form into a thrombus removal system, which further includes the push rod 200, the loading sheath 300, the microcatheter 400 and the sheath 500 described above, before use.

The proximal end of the thrombus taking support 1 is connected to the proximal tube 14 in a converging way through the rigid unit 11, the hollow proximal tube 14 is communicated with the push rod 200, the push rod 200 is a flexible tube capable of being bent radially, and the proximal end of the traction guide wire 2 sequentially penetrates out of the proximal tube 14 and the push rod 200.

The loading sheath 300 is arranged outside the push rod 200, and the thrombus taking-out stent 1 is pre-compressed and introduced into the loading sheath 300 before use, as shown in the state of fig. 4.

When a thrombolysis operation is desired, the loading sheath 300 may be connected to the microcatheter 400 by a connector 600 (e.g., luer connector), as shown in fig. 5. And further, the proximal tube 14 and the thrombus-taking stand 1 are pushed by the push rod 200 to smoothly enter the lumen of the micro-catheter 400, as shown in the state of fig. 6. The thrombus taking device 100 is then delivered to the lesion position where the thrombus is located, which is determined by radiography or other diagnostic means, through the microcatheter 400, so that the thrombus taking stent 1 is released at the vascular lesion position and the push-pull action can be accurately aligned through the push rod 200, thereby enabling the thrombus taking stent 1 to be switched between the compressed state and the released state.

The sheath 500 is sleeved outside the micro-catheter 400, and the sheath 500 extends into the blood vessel along with the micro-catheter 400 and is conveyed to the proximal end of thrombus at the lesion site, so as to accommodate the thrombus captured by the thrombus taking stent 1 during retraction.

Referring to fig. 7 to 12 in combination, in the interventional embolectomy, a puncture guide wire 700 is used to pre-pass through a thrombus at a lesion to establish a vascular access in the thrombus, as shown in fig. 7. Referring to fig. 8, the microcatheter 400 and sheath 500 are delivered to the thrombus site at the lesion site along the perforated guidewire 700, and the microcatheter 400 is passed over the thrombus, securing the microcatheter 400 and retracting the perforated guidewire 700. Referring to fig. 9, the embolic device 100 is advanced by a pusher rod 200 to a location of a thrombus as determined by contrast or other diagnostic means. Referring to fig. 10, the pushing rod 200 is stopped, the pushing rod 200 is fixed and the microcatheter 400 is retracted, so that the thrombus-taking stent 1 is released at the distal end of the microcatheter 400, the thrombus is ensured to be positioned in the effective area of the thrombus-taking device 100 according to the position of the development point on the image, and the thrombus-taking stent 1 is completely released in the blood vessel. Referring to fig. 11, the traction wire 2 can be adjusted according to the wall thickness of the blood vessel, so that the spiral unit is expanded and anchored on the wall of the blood vessel, thereby realizing the full fitting of the spiral unit and the wall of the blood vessel and catching thrombus. Referring to fig. 12, the traction wire 2 and the push rod 200 are pulled simultaneously to withdraw the thrombus taking-out stent 1 with the captured thrombus back into the sheath 500, thereby completing the removal of the thrombus.

Referring to fig. 13, when the conventional integrated thrombus-taking stent 1 is retracted in a continuously tortuous blood vessel, the thrombus-taking stent 1 is compressed into a linear shape during the retraction process due to the extrusion action of the round corners, and is embedded with thrombus, so that the volume is reduced, the probability of falling off the thrombus is increased, and the thrombus-taking effect and success rate are reduced.

Referring to fig. 14, the thrombus-taking stent 1 provided in this embodiment can be radially expanded and completely embedded into thrombus under the combined action of elastic release of the shape memory material and external force traction. Due to the flexibility of the device and the variable diameter of the internal spiral unit, the device can be fully expanded at the tortuous part of the blood vessel, and can keep relative static with thrombus during retraction, thereby effectively preventing the thrombus from falling off and further improving the thrombus taking effect and success rate. In addition, when the thrombus taking stent 1 is retracted from the distal blood vessel to the proximal blood vessel, the diameter of the blood vessel wall gradually becomes larger, and the thrombus taking device 100 can always keep the attached state in different sections of the blood vessel by adjusting the diameter of the spiral unit, so that the risk of thrombus falling off can be further reduced, and the thrombus taking effect and success rate are improved.

In the second embodiment, reference is made to the structure shown in fig. 15.

The thrombus removing device 100a of the present embodiment is similar in structure to the first embodiment, except for the difference in design of the rigid unit 11 a. Specifically, in the thrombectomy stent 1a of the present embodiment, among the rigid units 11a other than the two rigid units 11a located at the most proximal and most distal ends, the axial lengths of the plurality of rigid units 11a become sequentially smaller in the direction from the proximal end to the distal end of the thrombectomy stent 1 a. The axial length of the rigid unit 11a can be adjusted by varying the number of the first wave rings 111.

The maximum radial dimension D1 of the flexible units 12a is greater than the maximum radial dimension D2 of the rigid units 11a, so that a spacing space 10 can be formed between adjacent two flexible units 12a to catch thrombus. The axial dimension of the spacing space 10 may vary with the axial length of the rigid unit 11 a. Therefore, as the axial length of each rigid unit 11a becomes smaller in the proximal-distal direction, the axial dimensions of each space 10 become smaller simultaneously, and the thrombus size in each space 10 becomes smaller regularly.

When the thrombus taking support 1a is retracted in the circuitous blood vessel, the distal interval space 10 can not accommodate the proximal large thrombus, so that the large thrombus positioned in the proximal interval space 10 can be effectively prevented from migrating to the distal interval space 10, and is prevented from escaping to a farther place, and the risk of thrombus falling is further reduced.

It should be noted that the axial dimensions of each of the spaces 10 may be changed in other manners, for example, the axial dimensions of each of the spaces 10 may be sequentially increased in the proximal-to-distal direction, or may be alternately sized, or may be randomly sized, etc.

In the third embodiment, reference is made to the structure shown in fig. 16.

The thrombus removing device 100b of the present embodiment is similar to the structure of the first embodiment except for the design of the rigid unit 11 b.

Specifically, in the thrombus-taking stand 1b of the present embodiment, the radial width of each rigid unit 11b itself becomes gradually larger in the proximal-to-distal direction, among the rigid units 11b of the two rigid units 11b located at the most proximal and distal ends. The radial width of the rigid unit 11b can be adjusted by varying the distance of each first bellows 111 in the rigid unit 11b from the central axis of the rigid unit 11 b.

Since the radial width of the rigid unit 11b gradually increases in the proximal-distal direction, the surface of the rigid unit 11b may be tapered, and thus the size of the correspondingly formed space 10 may be gradually reduced. Corresponding to the large thrombus formed in the space 10, the structure gradually becomes smaller from the proximal end to the distal end is also presented. And further, the migration of the large thrombus in the interval space 10 to the far side can be effectively avoided, the escape of the large thrombus to the farther position is prevented, and the risk of thrombus falling off is further reduced.

Fourth embodiment, refer to the structure shown in fig. 17.

The thrombus removal device 100c of this embodiment is similar to the first embodiment in that the flexible unit 12c is designed differently.

Specifically, in the thrombectomy stent 1c of the present embodiment, in the natural expansion state, the maximum radial dimension D1 of each flexible unit 12c becomes larger in sequence in the direction from the proximal end to the distal end of the thrombectomy stent 1c, so that the distal flexible unit 12c can adjust its maximum radial dimension D1 in axial compression to accommodate larger vessels.

In the process of withdrawing the thrombus taking support 1c, as the blood vessel gradually becomes larger, the distal flexible unit 12c can have a larger maximum radial dimension D1 to be attached to the wall of the blood vessel, so that thrombus in the interval space 10 is prevented from escaping to the far distance, and the risk of thrombus falling off is further effectively reduced.

Fifth embodiment, refer to the structure shown in fig. 18.

The thrombus removing device 100d of the present embodiment is similar to the structure of the first embodiment except that the structure of the connecting arm 13 is omitted between the rigid unit 11d and the flexible unit 12d, and the rigid unit 11d and the flexible unit 12d of the thrombus removing stand 1d are directly connected.

In this embodiment, the end of the screw rod of the flexible unit 12d is directly connected to the crest 1111 or the trough 1112 of the first turn 111 of the rigid unit 11 d.

Sixth embodiment, refer to the structure shown in fig. 19.

In the thrombus removing device 100e of the present embodiment, a difference is in the structure of the flexible unit 12e as compared with the first embodiment.

The flexible unit 12e of the thrombus-taking stand 1e in this embodiment includes a plurality of struts 121e, and the plurality of struts 121e are circumferentially arranged at intervals to form a cylindrical structure. The spatial gaps between adjacent struts 121e form openings or mesh openings in the peripheral wall of the flexible unit 12 e; both ends of the supporting rod 121e are respectively connected to a connecting arm 13.

Referring to fig. 19 specifically, in the natural expansion state, the supporting rod 121e is an arc rod, the arc rod extends along the axial direction of the thrombus taking support 1e, the middle part of the arc rod protrudes outwards in an arc shape along the radial direction of the thrombus taking support 1e, and a plurality of arc rods are circumferentially spaced around the axis of the thrombus taking support 1e, so that the flexible unit 12e is in an approximately spherical or ellipsoidal shape in the natural expansion state. When the flexible unit 12e is axially compressed, the axial distance between the two ends of the arc-shaped rod is gradually reduced, the middle part of the arc-shaped rod radially expands outwards, and the protruding degree is increased, so that the maximum radial dimension D1 of the flexible unit 12e is gradually increased, the full fitting with the blood vessel wall and the full contact with thrombus are realized, and the effect of maximum embedding is realized.

The arc rod may be divided into a first arc segment 1211e and a second arc segment 1212e according to the distance from the arc rod to the centerline of the flexible unit 12e, with one end of the first arc segment 1211e and one end of the second arc segment 1212e being connected. The junction of the first arcuate segment 1211e and the second arcuate segment 1212e is the radially outermost side of the flexible unit 12 e. The first arc segment 1211e gradually becomes smaller in distance from the central axis of the flexible unit 12e in a direction gradually away from the second arc segment 1212 e. The second arc segment 1212e tapers in distance from the central axis of the flexible unit 12e in a direction gradually away from the first arc segment 1211 e.

Further, the flexible unit 12e also includes annular rings 124 at both ends of the arcuate bars. The two annular rings 124 are arranged at intervals, and the annular rings 124 are arranged around the axis of the thrombus-taking stand 1 e. The two ends of the arc rod are respectively connected with an annular ring 124, and the annular ring 124 can be directly connected with the rigid unit 11 or connected with the rigid unit 11 through a connecting arm 13. The annular ring 124 may be resilient to facilitate the overall contraction and expansion of the embolic stent 1 e.

Seventh embodiment referring to the structure shown in fig. 20 to 24.

In the thrombectomy device 100f of the present embodiment, the difference is in the structure of the flexible unit 12f and the traction guidewire 2f, as compared with the first embodiment.

In this embodiment, the outer peripheral wall of the flexible unit 12f of the thrombus removal stand 1f has a mesh structure, and the flexible unit 12f has a mesh-like structure similar to the rigid unit 11, and the mesh structure forms an opening in the outer peripheral wall of the flexible unit 12 f.

In a specific embodiment, referring to fig. 20 and 21, the flexible unit 12f includes a connecting member 123 and a second wave ring 122 that are axially and correspondingly connected. The connecting member 123 is located on the distal end side of the second wavy circle 122.

The connecting members 123 and the corresponding connected second wavy rings 122 may be provided in plural groups, and the connecting members 123 and the second wavy rings 122 between plural groups are alternately connected in sequence, so that the length of the flexible unit 12f may be increased, as shown in fig. 22 and 23.

Each second wave ring 122 has circumferentially alternating peaks 1221 and valleys 1222. With peaks 1221 facing distally and valleys 1222 facing proximally.

In the second wavy circle 122, a part of the wave crest 1221 is connected with the proximal end of the connecting piece 123, and the part of the wave crest 1221 is suspended. Thereby forming the flexible unit 12f integrally into a grid structure and forming notches at the suspended peaks 1221.

Specifically, the connecting member 123 may employ a plurality of rods bent in a V shape. The tip of each V-shaped connector 123 is proximal and meets the peak 1221 of the second undulating ring 122. The two ends of the V-shaped connecting piece 123 opposite to the tip are distal ends, and the two distal ends are respectively connected with a connecting arm 13; the two distal ends may also be adapted to interface with the valleys 1222 of another adjacent second undulating ring 122 when the sets of connectors 123 and second undulating rings 122 are alternately connected in sequence. The plurality of connecting members 123 are circumferentially spaced apart and cooperate with the second undulating ring 122 to form a tubular structure. A mesh or net structure may be formed between the connection 123 and the peaks 1221 or valleys 1222 of the second wave form ring 122.

Referring to fig. 24, under the action of a radial external force, the flexible unit 12f may bend at the notch formed by the suspended peak 1221, so as to improve the flexibility of the thrombus taking stent 1f and adapt to the curved blood vessel.

Referring to fig. 21, in the direction from the proximal end to the distal end, the distance from the center line of the flexible unit 12f of the second wave ring 122 gradually increases, so that the suspended peaks 1221 of the second wave ring 122 form free ends that expand outwards. The maximum width of the flexible unit 12f at the free end is the maximum radial dimension D1 of the flexible unit 12f, which maximum radial dimension D1 is larger than the maximum radial dimension D2 of the rigid unit 11. The free ends of the suspended peaks 1221 formed between two adjacent sets of second wavy turns 122 may be located at the same position or in a cross-distribution, as shown in fig. 22 and 23.

The flexible units 12f are capable of telescoping in a radial direction such that adjacent peaks 1221 and adjacent valleys 1222 between the second wave forms 122 may be closer to or farther from each other. When the flexible unit 12f naturally expands in the thrombus, the free end formed by the suspended peak 1221 may embed into the thrombus and conform to the vessel wall. A spacing space 10 is formed between corresponding suspended peaks 1221 of adjacent flexible units 12 f. When the thrombus taking support 1f is retracted, the free end formed by the suspended wave crest 1221 can push the complete thrombus in the interval space 10 to retract, so that the success rate of thrombus taking out is improved. While the free end formed by the suspended peak 1221 extends distally from the proximal end, so that retraction of the embolic stent 1f into the sheath 500 is not impeded.

It should be noted that the maximum radial dimension D1 of the flexible unit 12f is larger than the maximum radial dimension D1 of the rigid unit 11, and the adjustment control can be performed by the diameter of the second wave ring 122 at the peak 1221.

Further, in the second wave ring 122, the wave crests 1221 correspondingly connected to the proximal end of the connecting member 123 and the wave crests 1221 suspended are arranged at staggered intervals.

Notably, the flexible unit 12f of this embodiment is not radially expandable by axial compression.

Referring specifically to fig. 20, the flexible unit 12f has a second bellows 122 and a connecting member 123. Wherein the connecting member 123 is formed of two opposing V-shaped bars. The second undulating ring 122 may be considered to be a closed loop structure formed by a continuous curved extension of the rod in a Z-shape or W-shape having four distally located peaks 1221 and four proximally located valleys 1222. Two peaks 1221 are connected to the connecting member 123, and the other two peaks 1221 form free ends that hang in the air. The peaks 1221 that interface with the connector 123 are spaced apart from the suspended peaks 1221.

Referring to fig. 20 and 24, the distal end of the traction wire 2f in this embodiment is directly connected to the proximal end of the thrombus-taking out stent 1f, i.e. connected to the proximal tube 14, and the traction wire 2f does not need to extend into the thrombus-taking out stent 1 f. The proximal end of the traction guide wire 2f can be connected with the outside, and the traction guide wire 2f moves towards the proximal end of the blood vessel to drive the thrombus taking support 1f to integrally retract towards the proximal end.

Eighth embodiment, refer to the structure shown in fig. 25 and 26.

The thrombectomy device 100g of this embodiment is similar in structure to the first embodiment, except for the design of the traction guide wire 2 g.

The traction guidewire 2g of the present embodiment includes a guidewire core 21 and a heating portion 22 provided on the guidewire core 21.

The wire core 21 is made of conductive material and penetrates through the thrombus taking support 1 g. One end of the guide wire core 21 extends out of the thrombus taking support 1g and can be electrically connected to an external power supply; the heating part 22 is positioned in the thrombus taking bracket 1 g; in the energized state of the guide wire core 21, the heating part 22 can generate joule heat, so that thrombus in the surrounding area of the heating part 22 is dehydrated, contracted and coagulated, and tightly adhered to the heating part 22, the capturing effect of thrombus is improved, and further, when the thrombus taking support 1g and the traction guide wire 2g are retracted, the thrombus can be effectively prevented from falling off, and the thrombus taking effect and success rate are improved.

The external power source may be a radio frequency power source, and when the wire guide core 21 is energized with radio frequency current, a radio frequency thermal ablation effect may be formed around the heating portion 22.

The wire core 21 is covered with an insulating layer 23 in a region other than the heat generating portion 22. The insulating layer 23 is a layer of insulating material wrapped on the guide wire core 21, and can be sleeved or adhered on the guide wire core 21.

The heat generating portion 22 is a layer of heat conducting medium. The heating part 22 and the wire guide core 21 may be integrally formed, and the heating part 22 may be bonded or welded to the wire guide core 21.

The heating part 22 protrudes from the outer peripheral wall of the guide wire core 21 in the radial direction to increase the heating area thereof, thereby further improving the catching ability of thrombus. Of course, the heat generating portion 22 may not protrude from the outer peripheral wall of the guide wire core 21.

The radial width of the heating portion 22 gradually increases from both ends to the middle, so that a structure with small dimensions at both ends and large dimensions in the middle is formed, and the flow resistance of the heating portion 22 to blood flow is reduced after the blood flow channel is opened. Specifically, the heat generating portion 22 may have an oval sphere structure, and both ends of the oval sphere are arranged corresponding to the proximal end and the distal end of the thrombus taking stand 1g, respectively. The outer peripheral wall of the heating part 22 is in a smooth transitional streamline shape, namely, the proximal end and the distal end of the heating part 22 are both in a streamline design.

In the thrombus taking out holder 1g of the present embodiment, the heat generating portion 22 can be disposed in the rigid unit 11 or the flexible unit 12, respectively. The heat generating portion 22 may be provided in plurality, and the plurality of heat generating portions 22 are arranged at intervals.

Preferably, the heat generating portion 22 may be arranged in correspondence with the rigid units 11 so as to enhance the catching ability of the large thrombus falling in the space region between the adjacent two flexible units 12.

Ninth embodiment, refer to the structure shown in fig. 27.

The thrombectomy device 100h of this embodiment is similar in structure to the eighth embodiment, except for the design of the traction guide wire 2 h.

The traction guide wire 2h of the present embodiment includes a guide wire core 21h, a heat generating portion 22h provided on the guide wire core 21h, and an elastic portion 24 provided on the guide wire core 21h and arranged at a distance from the heat generating portion 22 h.

The elastic part 24 has a segment-shaped structure and is correspondingly arranged in the flexible unit 12. The heat generating portion 22h is provided in the rigid unit 11.

The thrombolytic stent 1h of the present embodiment further includes a plurality of connecting rods 16. Both ends of the elastic portion 24 are connected to the peripheral wall of the thrombolytic stent 1h by one or more connecting rods 16, respectively. I.e. the inner end of each connecting rod 16 is connected to the end of the elastic portion 24, and the outer end of the connecting rod 16 may be connected to the peripheral side wall of the rigid unit 11 or the flexible unit 12, or to the connecting arm 13. The two ends of the elastic part 24 are relatively fixed with the thrombus taking support 1h through the connecting rod 16, so that the elastic part 24 is limited in the corresponding flexible unit 12 in a aligned manner, and meanwhile, the heating parts 22h are correspondingly distributed in the rigid unit 11.

The elastic portion 24 may be in a stretched state in a state where the thrombolytic stent 1h is kept collapsed. As shown in fig. 27, the flexible unit 12 may be self-expanding when the thrombolytic stent 1h is released within the vessel. And when self-expanding and radially deployed, the axial dimension thereof is shortened. The restoring force of the elastic part 24 can assist the expansion of the thrombus taking bracket 1h, so that the thrombus taking bracket 1h can be quickly unfolded; and the length of the elastic portion 24 shortens synchronously with the axial dimension of the flexible unit 12 during radial expansion of the flexible unit 12.

The connecting rod 16 is telescopic along the radial direction of the thrombus taking support 1h, such as a wave-shaped rod, an elastic telescopic member or the like. The connecting rod 16 can be stretched when the thrombolytic stent 1h is expanded. When the thrombus-taking stand 1h is contracted to a collapsed state, the connecting rod 16 can be compressed to facilitate the receiving of the connecting rod 16 in the sheath 500, and the collapsed state is maintained together with the thrombus-taking stand 1 h.

While the invention has been described with reference to several exemplary embodiments, it is to be understood that the terminology used is intended to be in the nature of words of description and of limitation. As the present invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, it should also be understood that the above-described embodiments are not limited by any of the details of the foregoing description, but rather should be construed broadly within its spirit and scope as defined in the appended claims, and therefore all changes and modifications that fall within the meets and bounds of the claims, or equivalences of such meets and bounds are therefore intended to be embraced by the appended claims.

Claims

1. The thrombus taking support is characterized by comprising rigid units and flexible units which are arranged in a linear mode and are alternately connected;

the rigid unit and the flexible unit are both in a radially compressible and expandable tubular structure;

the flexible unit is easier to bend and deform than the rigid unit when subjected to the same radial force;

In a natural expansion state, the maximum radial dimension of the flexible unit is greater than the radial dimension of the rigid unit;

The flexible unit comprises a connecting piece and a wavy ring which are connected in an axial corresponding manner; the connecting piece is positioned at the far end side of the wavy circle;

Each wave-shaped ring is provided with staggered wave crests and wave troughs along the circumferential direction; a part of wave crests of the wave form ring are connected with the proximal end of the connecting piece, and the part of wave crests of the wave form ring are suspended;

in the wave ring, wave crests which are correspondingly connected with the connecting piece and the suspended wave crests are arranged at staggered intervals;

The flexible unit is easier to axially compress than the rigid unit when subjected to an equivalent axial force; and the radial dimensions of the flexible unit increase simultaneously when it is compressed axially.

2. The thrombolytic stent of claim 1, wherein said connecting member comprises a plurality of circumferentially spaced apart V-shaped bars, said V-shaped bars being bent in a V-shape;

The vertex of the V-shaped rod is a proximal end and is connected with the wave crest of the wave ring;

The two ends of the V-shaped rod opposite to the vertex of the V-shaped rod are distal ends, and the two distal ends of the V-shaped rod are used for being connected with the rigid unit or connected with the trough of another wave-shaped ring.

3. The thrombolytic stent of claim 2, wherein said flexible unit comprises a plurality of helical rods wound in the same direction, a plurality of said helical rods being circumferentially spaced apart;

the two ends of the screw rod are respectively connected with one rigid unit.

4. A thrombolytic stent as claimed in claim 3 wherein the winding angle from one end of said screw rod to the other end of said screw rod is in the range of 0-360 °.

5. The thrombolytic stent of claim 3, wherein said screw rod comprises a first winding section and a second winding section connected at one end, said first winding section and said second winding section being both helically wound;

In a natural expansion state, the distance from the first winding section to the central axis of the flexible unit gradually becomes smaller in the direction gradually away from the second winding section; the second winding section gradually becomes smaller in distance from the central axis of the flexible unit in a direction gradually away from the first winding section; the connection part of the first winding section and the second winding section is the outermost side of the flexible unit in the radial direction.

6. The thrombolytic stent of claim 1, further comprising a connecting arm, said rigid unit and said flexible unit being connected by said connecting arm, said connecting arm being rod-shaped.

7. The thrombolytic stent of claim 6, wherein a plurality of said connecting arms are provided, a plurality of said connecting arms being distributed along a circumference of said rigid unit.

8. The thrombolytic stent of any of claims 1-7, wherein both a proximal-most end and a distal-most end of said thrombolytic stent are said rigid units.

9. The thrombectomy stent of any one of claims 1-7, wherein the maximum radial dimension of the plurality of flexible units in the thrombectomy stent sequentially increases in a proximal-to-distal direction in a naturally expanded state.

10. The thrombolytic stent of any of claims 1-7, wherein for a set of rigid units disposed between two adjacent flexible units, the axial length of a plurality of said rigid units in said set decreases in sequence in a direction from the proximal end to the distal end of said thrombolytic stent.

11. The thrombolytic stent of any of claims 1-7, wherein for a set of rigid units disposed between two adjacent said flexible units, the radial dimension of each of said rigid units in said set becomes progressively larger in a proximal-to-distal direction.

12. A thrombolytic device comprising a thrombolytic stent according to any of claims 1-11 and a traction guidewire connected to said thrombolytic stent.

13. The thrombectomy device of claim 12, further comprising a distal tube and a proximal tube;

the most distal end of the thrombus taking support is connected to the distal tube in a converging way; the nearest end of the thrombus taking support is converged and connected to the proximal tube.

14. The thrombectomy device of claim 13, wherein a distal end of the pull wire is connected to the proximal tube.

15. The thrombectomy device of claim 13, wherein the proximal tube is a hollow tube; the traction guide wire passes through the proximal tube and sequentially passes through the rigid unit and the flexible unit, and the distal end of the traction guide wire is connected with the distal tube.

16. The thrombectomy device of claim 15, wherein the distal tube is a hollow tube and the distal end of the distraction guidewire extends out of the distal tube and is snapped onto the distal end of the distal tube.

17. The thrombectomy device of claim 15, wherein a heating portion is provided on the traction guidewire, the heating portion being disposed correspondingly within the rigid unit or the flexible unit;

The traction guidewire may be electrically connected to an external power source; in the energized state, the heat generating portion can generate heat.

18. A thrombolysis system comprising the thrombolysis device of any one of claims 12-17, a pushrod, a loading sheath, and a microcatheter;

the push rod is connected with the proximal end of the thrombus taking support and is used for pushing and pulling the thrombus taking support;

The loading sheath is used for accommodating the thrombus taking device in a compressed state;

The microcatheter is used for communicating with the loading sheath, and a lumen in the microcatheter is used for conveying the thrombus taking device.