CN112168181A - Brain tissue blood oxygen saturation detection device and preparation method thereof - Google Patents
Brain tissue blood oxygen saturation detection device and preparation method thereof Download PDFInfo
- Publication number
- CN112168181A CN112168181A CN202011114382.2A CN202011114382A CN112168181A CN 112168181 A CN112168181 A CN 112168181A CN 202011114382 A CN202011114382 A CN 202011114382A CN 112168181 A CN112168181 A CN 112168181A
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- brain tissue
- optical fibers
- oxygen saturation
- blood oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a detecting device for the blood oxygen saturation of brain tissue and a preparation method thereof, wherein the detecting device for the blood oxygen saturation of brain tissue comprises: the measuring body is composed of a plurality of optical fibers which are arranged side by side and fixedly connected with each other, wherein one optical fiber is used as a transmitting optical fiber, the other optical fibers are used as transmitting optical fibers, the distance between each transmitting optical fiber and the tip end of each transmitting optical fiber is preset, and the transmitting optical fibers are precisely cut or ground to form a mirror surface with a preset angle.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a device for detecting the blood oxygen saturation of brain tissue and a preparation method thereof.
Background
With the continuous development of modern medical technology and related disciplines, medical monitoring instruments become an indispensable large class of instruments for medical electronic instruments, and play an increasingly important role in hospitals. The monitoring instrument is used, so that the labor of medical staff is reduced, the efficiency of medical work is improved, and more importantly, a doctor can know the state of an illness in time.
Brain tissue oxygen supply is the material basis for maintaining the most basic signs of life, as well as the higher vital activities (consciousness, thinking, movement). Hypoxia of brain tissue can lead to disturbance of consciousness, hemiplegia and even coma, and death. The understanding of the oxygen content in brain tissue is of great clinical significance. For patients with craniocerebral injury, cerebral hemorrhage and craniotomy, cerebral tissue edema, intracranial pressure increase and cerebral tissue blood flow perfusion are often accompanied, so that oxygen supply to the cerebral tissue is insufficient, oxygen partial pressure or oxygen saturation is reduced, the life quality and life safety of the patients are seriously threatened, and heavy burden is brought to medical resources and society. Therefore, monitoring the oxygen-containing condition of brain tissue is an urgent problem to be solved in clinical practice
Currently, there are two main ways to monitor the oxygen content of brain tissue:
1. invasive monitoring: the sensor is inserted into brain tissue through a drill hole on a skull or a bone seam between a bone flap formed by a craniotomy and the skull, is led out from a skull puncture hole in a subcutaneous tunnel walking mode, and is connected to an external upper computer. The upper computer measures the oxygen partial pressure of the brain tissue through a specific signal processing method and algorithm. The current mature products mainly comprise a German Raumedic cerebral oxygen partial pressure monitoring system and a U.S. Camino cerebral oxygen partial pressure monitoring system. In the former (Raumedic), a fluorescent substance is coated on the tip (single end) of the ultra-fine Y-shaped optical fiber, and a gas-permeable membrane material with biocompatibility is coated outside the fluorescent substance, so that oxygen molecules can diffuse to the fluorescent substance. When external specific wavelength laser is emitted through one branch of the tail end of the Y-shaped optical fiber, the fluorescent substance is excited at a certain pulse frequency, and the fluorescent substance generates fluorescence with specific wavelength after being excited. Oxygen molecules diffuse from the brain tissue through the gas permeable membrane, contacting the fluorescent material, causing quenching of the fluorescence. The fluorescence signal can be led out through the other branch of the tail end of the Y-shaped optical fiber. By analyzing the fluorescence lifetime or intensity through an external device, the oxygen content of the tip can be calculated, so that the partial pressure condition of the brain oxygen can be known. In the latter case, Clark electrodes (Au, Ag or Pt, etc.) are fabricated at the tip of the catheter, and oxygen in brain tissue permeates cell membranes to participate in electrochemical reaction between the electrodes to generate electric current. The current between the electrodes is monitored by external equipment, so that the brain oxygen content at the electrodes can be analyzed.
However, in fact, both the fiber optic sensor based on laser-excited fluorescence quenching and the electrochemical sensor based on the Clark electrode principle have significant limitations. The brain oxygen monitored by the two sensors is oxygen molecules permeating from brain tissue cells. The former needs to pass through the gas permeable membrane, and the oxygen molecule transmittance of the gas permeable membrane seriously affects the accuracy of the measurement result. Moreover, when the monitoring time is long, the fluorescent substance can be greatly inactivated and even lost, and the measurement accuracy is also seriously affected. In the latter case, once blood clots or other substances are attached to the surface of the Clark electrode (which is very common), oxygen in brain tissue cannot participate in the electrochemical reaction between the electrodes, resulting in inaccurate or even failed measurement. In addition, the current generated by the electrochemical sensor is weak, and signals are easily interfered in the transmission process, so that the measurement accuracy is influenced.
Because of the limitations described above, and the high production costs of sensors for both technical routes, even though, as mentioned above, cerebral oxygen monitoring is of great significance, these two types of sensors have been almost out of use in the clinic.
2. Non-invasive monitoring: noninvasive brain oxygen monitoring based on NIRS (near infrared spectroscopy) principle has recently begun to be applied clinically. The basic principle is as follows: the blood oxygen saturation sensor is attached to the forehead of the cranium of a patient, and the probe of the blood oxygen sensor is provided with two visible light and near infrared diodes with different wave bands and a photoelectric sensor capable of receiving the wave bands. The visible light and the light signals with two frequencies emitted by the infrared diode pass through the scalp and the skull, enter the brain tissue, are scattered by various cells in the brain tissue, return in an arc shape similar to a parabola, pass through the skull, the scalp and other tissues, and are received by the photoelectric sensor attached to the scalp. The absorption peaks of hemoglobin and oxyhemoglobin correspond to the emitted optical signals with two frequencies. According to Lambert-Beer's law, the absorption intensity of optical signals of two frequency bands is positively correlated with the concentration of hemoglobin and oxygenated hemoglobin. The ratio of oxyhemoglobin to hemoglobin reflects the oxygen saturation in brain tissue.
The method is convenient to monitor and low in cost, but the limitation is obvious: visible light or near infrared light penetrates the skin and then needs to penetrate the skull to enter the brain tissue, so that the diode and the sensor are required to be closely attached to the scalp and can only be applied to a thinner part of the skull. At present, the products can only be pasted on the forehead and have no hair covering part. Even so, the light signal enters the brain tissue and is scattered to the photoelectric sensor, and needs to pass through the skull twice, and the scalp and the blood supply of the skull can absorb and reflect the photoelectric signal, so that larger background noise is brought. And after passing through the scalp and the skull, the signal attenuation is serious, so the surface of the detectable brain tissue is shallow, and the depth of the brain tissue is about 5-10 mm. And the optical signals are dispersed, so that the brain oxygen condition of specific brain tissues cannot be monitored.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide a device for detecting the blood oxygen saturation of brain tissue and a preparation method thereof, which aim to lead in and out optical signals by designing a simple reflection structure at the tip of an optical fiber so as to realize the monitoring requirement of the brain oxygen saturation of a specific part.
To achieve the above and other objects, the present invention provides a device for detecting blood oxygen saturation in brain tissue, comprising: the measuring body is composed of a plurality of optical fibers which are arranged side by side and fixedly connected with each other, wherein one optical fiber is used as a transmitting optical fiber, the other optical fibers are used as transmitting optical fibers, the distance between each transmitting optical fiber and the tip end of each transmitting optical fiber is preset, and the transmitting optical fibers are precisely cut or ground to form a mirror surface with a preset angle.
Preferably, the optical fibers are adhesively secured to each other by an adhesive using an implantable medical device.
Preferably, the tip of each optical fiber is precisely cut or ground to form a slope of a predetermined angle, and gold or other metal is plated at the slope thereof to form a mirror surface.
Preferably, the metal exterior is coated or otherwise modified to make it biocompatible for use in brain tissue.
Preferably, a heat shrinkable tube or coating is used on the outside of each optical fiber to make the surface of each optical fiber regular and to maintain the position relationship of the optical fibers therein constant.
Preferably, the distance between the tips of the incoming and outgoing optical fibers depends on the design requirements for the detection depth.
Preferably, the angle of the mirror formed by the tip of each optical fiber is 0 ° to 90 °, excluding 0 ° and 90 °.
Preferably, after the optical fiber is ground to be flat, the prism is processed into a cubic column or prism, a mirror surface with a preset angle is formed at the tip of each optical fiber, so that the total reflection of light in the optical fiber is destroyed, and the light is emitted or transmitted.
In order to achieve the above object, the present invention further provides a method for preparing a device for detecting blood oxygen saturation of brain tissue, comprising the following steps:
step S1, precisely cutting or grinding the tips of the optical fibers to form a mirror surface with a preset angle;
step S2, arranging the optical fibers side by side and fixedly connecting them, where one optical fiber is used as an outgoing optical fiber, the other optical fibers are used as incoming optical fibers, and each incoming optical fiber has a preset distance from the tip of the outgoing optical fiber.
Preferably, in step S1, the optical fiber is polished to a certain length at each optical fiber tip, and then processed into a mirror surface with a predetermined angle to destroy the total reflection of light in the optical fiber, so that the light can be transmitted into or out of the optical fiber.
Compared with the prior art, the invention provides the brain tissue blood oxygen saturation detection device and the preparation method thereof, so that the aim of invasive tissue oxygen saturation monitoring in vivo (not only in brain tissue, but also in blood vessels, liver, kidney and the like) is fulfilled by designing a simple reflection structure at the tip of the optical fiber and leading in and out optical signals.
Drawings
FIG. 1 is a schematic structural diagram of a device for detecting blood oxygen saturation in brain tissue according to the present invention;
FIG. 2 is a schematic diagram of a device for detecting blood oxygen saturation in brain tissue according to the present invention;
FIG. 3 is a schematic diagram illustrating the prevention of total reflection of light according to an embodiment of the present invention;
FIG. 4 is a flowchart illustrating the steps of a method for manufacturing a device for detecting blood oxygen saturation in brain tissue according to the present invention.
Detailed Description
Other advantages and capabilities of the present invention will be readily apparent to those skilled in the art from the present disclosure by describing the embodiments of the present invention with specific embodiments thereof in conjunction with the accompanying drawings. The invention is capable of other and different embodiments and its several details are capable of modification in various other respects, all without departing from the spirit and scope of the present invention.
Fig. 1 is a schematic structural diagram of a device for detecting blood oxygen saturation of brain tissue according to the present invention. As shown in fig. 1, the present invention provides a device for detecting blood oxygen saturation in brain tissue, comprising: the measuring body is arranged side by side, one optical fiber is used as an outgoing optical fiber, the other optical fibers are used as incoming optical fibers, the incoming optical fibers are at a certain distance from the tip end of the outgoing optical fiber, the optical fibers are fixedly connected with each other, for example, the optical fibers are fixed by means of bonding and the like (for example, adhesive of implantable medical equipment is adopted), and if necessary, heat-shrinkable tubes (C), coatings and the like can be used outside the optical fibers to ensure that the surfaces of the optical fibers are regular and the position relation of the optical fibers inside the optical fibers can be kept fixed; the tip of each optical fiber is precision cut or ground to form an angled bevel and gold or other metal is plated on the bevel to form a mirror surface. Preferably, the metal exterior may be coated or otherwise modified as necessary to make it biocompatible for use in brain tissue. Preferably, for in vivo use, the optical fiber used should be sterilizable. In the invention, the number and the bevel angle of the specific optical fibers can be adjusted according to actual requirements.
In the embodiment of the present invention, two optical fibers (a, B) are taken as an example, where a is an incoming optical fiber, B is an outgoing optical fiber, and a distance between two tips with mirror surfaces of the incoming optical fiber a and the outgoing optical fiber B depends on a requirement of a detection depth (detection range) in design.
The angle of the two mirror surfaces formed by the incoming fiber a and the outgoing fiber B can be set between 0 ° and 90 ° (0 ° and 90 ° are not included here because when 0 °, the reflecting mirror surface is almost parallel to the incident light, and the diffusely reflected light cannot be reflected after entering the fiber; 90 °, the fiber cannot be processed). The specific angle value needs to be designed according to the optical fiber processing and practical application scenarios. Generally, at 45 °, the light enters the optical fiber, and can be transmitted along the long axis of the optical fiber by specular reflection, theoretically with the least attenuation, the maximum detection light intensity can be obtained, and the detection is more sensitive, so in the embodiment of the present invention, the angle of the inclined planes (M, N) of the incoming optical fiber a and the outgoing optical fiber B is 45 °, and gold plating or other metals are performed at the inclined planes (M, N) to form the mirror surface.
As shown in figure 2, when in use, light signals with different frequencies are alternately introduced from an incoming optical fiber A, the signals enter brain tissue through M specular reflection at the tip of the incoming optical fiber A, scattered light is reflected through N specular reflection of an optical fiber B, the light signals are led out from the optical fiber B, and synchronous measurement is carried out in extracorporeal equipment. When optical signals of specific absorption peak wavelengths of the hemoglobin and the oxyhemoglobin are alternately introduced, corresponding absorption intensities can be alternately measured, so that the oxygen saturation condition of brain tissues can be known.
In fact, the oxygen saturation change of the brain tissue is relatively stable in the ms level time, and therefore, when the switching frequency is fast (ms level) for the optical signals of different wavelengths introduced into the optical fiber a, the measured hemoglobin absorption peak intensity and the oxygenated hemoglobin absorption peak intensity can be approximately considered to be the same time.
Preferably, if the requirements are strict, it is necessary to measure the absorption intensity of the optical signals of two frequencies "simultaneously", and one optical fiber may be added as the incoming optical fiber, still arranged side by side as above, with its tip spaced from the B optical fiber by a certain distance.
Preferably, in order to enable the optical signal of the incoming optical fiber to smoothly exit from the optical fiber and enable the reflected optical signal of the brain tissue to smoothly enter into the outgoing optical fiber, the situation of total reflection of light needs to be avoided. Therefore, the optical fiber tip needs to be processed into a prism or a square prism with four sides by grinding the original cylinder with a certain length. Generally, the function of an optical fiber is to transmit light in a glass material without transmitting through the material, which means that the optical fiber cannot pass through a circular interface between the optical fiber and the surrounding air or other substances during transmission due to the principle of total reflection. Therefore, at the portion where the emission or introduction of each fiber is required (i.e., at the fiber tip mirror), two ways can be taken, including but not limited to: 1. the surface of the optical fiber is corroded by hydrofluoric acid (HF), so that the optical fiber is atomized, the smooth surface of the optical fiber is roughened, the effect similar to that of frosted glass is achieved, the circular interface between the optical fiber and an adjacent medium is damaged, and the purpose of ejection or transmission is achieved; 2. the circular interface is ground to become a plane or a polygon, and light can be emitted or transmitted, as shown in fig. 3, the total reflection of light in the optical fiber can be destroyed only by destroying the circular shape of the optical fiber interface at the position d, whether the optical fiber interface is ground flat or atomized or formed into other shapes (prisms), so that the light can be emitted or transmitted.
FIG. 4 is a flowchart illustrating the steps of a method for manufacturing a device for detecting blood oxygen saturation in brain tissue according to the present invention. As shown in fig. 4, the method for preparing a device for detecting blood oxygen saturation of brain tissue according to the present invention comprises the following steps:
step S1, the tips of the optical fibers are precisely cut or ground to form an inclined plane with a certain angle, and gold plating or other metals are performed on the inclined plane to form a mirror surface.
In a specific embodiment of the invention, the angle of the slope of each fiber tip is between 0 ° and 90 ° (0 ° and 90 ° are not included here because at 0 °, the mirror surface is almost parallel to the incident light and the diffusely reflected light is not reflected after entering the fiber; 90 °, the fiber cannot be processed). The specific angle value needs to be designed according to the optical fiber processing and practical application scenarios. Generally, at 45 °, the light enters the light, and can be transmitted along the long axis of the light just by specular reflection, theoretically with the least attenuation, the maximum detection light intensity can be obtained, and the detection is more sensitive, so in the embodiment of the invention, taking two optical fibers a and B as an example, the tips of the two optical fibers a and B are precisely cut or ground, the angle of the tip inclined plane (M, N) formed is 45 °, and gold plating or other metals are performed at the inclined plane (M, N) to form the mirror surface. If necessary, the metal can be coated or otherwise modified on the outside to make it biocompatible for use in brain tissue.
Step S2, arranging and fixing the optical fibers side by side, wherein one optical fiber is used as an outgoing optical fiber, the other optical fibers are used as incoming optical fibers, and each incoming optical fiber is spaced from the outgoing tip by a certain distance. In a specific embodiment of the present invention, each optical fiber is fixed by means of bonding or the like. If necessary, a heat shrinkable tube, a coating, or the like may be used outside the optical fiber to make the surface thereof regular and to maintain the positional relationship of the optical fiber therein fixed.
In the specific embodiment of the present invention, still taking the two optical fibers (a, B) as an example, the optical fibers a and B are arranged side by side, the tips are at a certain distance and fixed by means of adhesion or the like, where a is an incoming optical fiber and B is an outgoing optical fiber, and the distance between the two tips with mirror surfaces of the incoming optical fiber a and the outgoing optical fiber B is increased as needed if a brain tissue with a larger detection depth (detection range) needs to be detected, and vice versa, the specific relationship between the distance parameter and the detection range can be calculated according to a parabolic fitting formula, which is disclosed in the literature of the prior art and is not described herein again.
Preferably, in order to enable the optical signal of the incoming optical fiber to smoothly exit from the optical fiber and enable the reflected optical signal of the brain tissue to smoothly enter into the outgoing optical fiber, the situation of total reflection of light needs to be avoided. Therefore, in step S1, the optical fiber tip is further processed into a prism or a square prism with four sides by polishing or the like with a predetermined length. Generally, the function of an optical fiber is to transmit light in a glass material without transmitting through the material, which means that the optical fiber cannot pass through a circular interface between the optical fiber and the surrounding air or other substances during transmission due to the principle of total reflection. Therefore, at the portion where the emission or introduction of each fiber is required (i.e., at the fiber tip mirror), two ways can be taken, including but not limited to: 1. the surface of the optical fiber is corroded by hydrofluoric acid (HF), so that the optical fiber is atomized, the smooth surface of the optical fiber is roughened, the effect similar to that of frosted glass is achieved, the circular interface between the optical fiber and an adjacent medium is damaged, and the purpose of ejection or transmission is achieved; 2. the circular interface is polished to become a plane or a polygon, so that light can be emitted or transmitted.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Therefore, the scope of the invention should be determined from the following claims.
Claims (10)
1. A brain tissue blood oxygen saturation detection device, comprising: the measuring body is composed of a plurality of optical fibers which are arranged side by side and fixedly connected with each other, wherein one optical fiber is used as a transmitting optical fiber, the other optical fibers are used as transmitting optical fibers, the distance between each transmitting optical fiber and the tip end of each transmitting optical fiber is preset, and the transmitting optical fibers are precisely cut or ground to form a mirror surface with a preset angle.
2. The device for detecting blood oxygen saturation level of brain tissue according to claim 1, wherein: the optical fibers are fixed by adhesion with an adhesive agent for implantable medical devices.
3. The device for detecting blood oxygen saturation level of brain tissue according to claim 1, wherein: the tip of each optical fiber is precisely cut or ground to form a slope of a predetermined angle, and gold plating or other metals are performed at the slope to form a mirror surface.
4. The device for detecting blood oxygen saturation level of brain tissue according to claim 3, wherein: the metal exterior is coated or otherwise modified to make it biocompatible for use in brain tissue.
5. The device for detecting blood oxygen saturation level of brain tissue according to claim 4, wherein: the heat shrinkable tube and the coating are used outside each optical fiber, so that the surface of each optical fiber is regular, and the position relation of the optical fibers inside each optical fiber can be kept fixed.
6. The device for detecting blood oxygen saturation level of brain tissue according to claim 4, wherein: the distance between the tips of the incoming and outgoing optical fibers depends on the design requirements for the depth of detection.
7. The device for detecting blood oxygen saturation level of brain tissue according to claim 4, wherein: the tip of each optical fiber forms a mirror angle of 0 ° to 90 °, excluding 0 ° and 90 °.
8. The device for detecting blood oxygen saturation level of brain tissue according to claim 4, wherein: at the tip of each optical fiber, the optical fiber is ground to be flat, and a mirror surface with a preset angle is formed after the cubic column and the prism are processed, so that the total reflection of light in the optical fiber is destroyed, and the light is emitted or transmitted.
9. A method for preparing a device for detecting the blood oxygen saturation of brain tissue comprises the following steps:
step S1, precisely cutting or grinding the tips of the optical fibers to form a mirror surface with a preset angle;
step S2, arranging the optical fibers side by side and fixedly connecting them, where one optical fiber is used as an outgoing optical fiber, the other optical fibers are used as incoming optical fibers, and each incoming optical fiber has a preset distance from the tip of the outgoing optical fiber.
10. The method for preparing a device for detecting blood oxygen saturation of brain tissue according to claim 8, wherein: in step S1, the tips of the optical fibers are ground to a certain length, and the optical fibers are processed into a mirror surface with a predetermined angle to destroy the total reflection of light in the optical fibers, so that the light can be transmitted into or out of the optical fibers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011114382.2A CN112168181B (en) | 2020-10-16 | 2020-10-16 | Brain tissue blood oxygen saturation detection device and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011114382.2A CN112168181B (en) | 2020-10-16 | 2020-10-16 | Brain tissue blood oxygen saturation detection device and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112168181A true CN112168181A (en) | 2021-01-05 |
| CN112168181B CN112168181B (en) | 2023-07-11 |
Family
ID=73950729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011114382.2A Active CN112168181B (en) | 2020-10-16 | 2020-10-16 | Brain tissue blood oxygen saturation detection device and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112168181B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331570A (en) * | 1998-10-19 | 2002-01-16 | 里奥格兰德医学技术有限公司 | Method for non-invasive blood analyte measurement with improved optical interface |
| US20080045822A1 (en) * | 2003-12-22 | 2008-02-21 | Phillips Justin P | Optical Fibre Catheter Pulse Oximeter |
| US20100049019A1 (en) * | 2008-08-22 | 2010-02-25 | Pulsion Medical Systems Ag | Fiber-optic probe |
| CN104677290A (en) * | 2015-03-05 | 2015-06-03 | 哈尔滨工业大学 | Method for manufacturing double-core fiber grating micro-scale measurement probe based on self-assembly principle |
| CN106596474A (en) * | 2016-12-05 | 2017-04-26 | 重庆三峡学院 | Three-channel SPR (surface plasma resonance) sensor based on seven-core optical fiber |
-
2020
- 2020-10-16 CN CN202011114382.2A patent/CN112168181B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331570A (en) * | 1998-10-19 | 2002-01-16 | 里奥格兰德医学技术有限公司 | Method for non-invasive blood analyte measurement with improved optical interface |
| US20080045822A1 (en) * | 2003-12-22 | 2008-02-21 | Phillips Justin P | Optical Fibre Catheter Pulse Oximeter |
| US20100049019A1 (en) * | 2008-08-22 | 2010-02-25 | Pulsion Medical Systems Ag | Fiber-optic probe |
| CN104677290A (en) * | 2015-03-05 | 2015-06-03 | 哈尔滨工业大学 | Method for manufacturing double-core fiber grating micro-scale measurement probe based on self-assembly principle |
| CN106596474A (en) * | 2016-12-05 | 2017-04-26 | 重庆三峡学院 | Three-channel SPR (surface plasma resonance) sensor based on seven-core optical fiber |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112168181B (en) | 2023-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7277740B2 (en) | Analysis system for reagent-free determination of the concentration of an analyte in living tissue | |
| Mignani et al. | Biomedical sensors using optical fibres | |
| JP3625475B2 (en) | Non-intrusive system for monitoring hematocrit values | |
| US6041247A (en) | Non-invasive optical measuring sensor and measuring method | |
| US5280786A (en) | Fiberoptic blood pressure and oxygenation sensor | |
| US5817009A (en) | Arrangement for noninvasive determination of the oxygen saturation in human blood vessels or organs | |
| TW201726060A (en) | Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry | |
| CN107427219B (en) | Photoacoustic sensing apparatus and method of operating the same | |
| JPH06261890A (en) | Sensor device | |
| Mignani et al. | In-vivo biomedical monitoring by fiber-optic systems | |
| Barker et al. | Continuous Measurement of Intraarterial pHa, Paco2, and Pao2, in the Operating Room | |
| WO2011091439A2 (en) | Fiberoptic probe for measuring tissue oxygenation and method for using same | |
| CN111956234A (en) | Accurate blood oxygen saturation measuring method and device based on photoacoustic technology | |
| CN110537926B (en) | Needle, device and method for detecting hemoglobin concentration and blood oxygen saturation | |
| CN206526025U (en) | A kind of detecting head for brain scans | |
| US5419322A (en) | Internal apparatus for continuous electrical and oximetric intrapartum monitoring of the fetus | |
| Martin et al. | Fibre-optics and optical sensors in medicine | |
| JP2008289807A (en) | Sensing apparatus for biological surface tissue | |
| CN112168181B (en) | Brain tissue blood oxygen saturation detection device and preparation method thereof | |
| US7508999B2 (en) | Fiber optic sensor device for measuring chromophoric compounds in biological fluid | |
| CN206526049U (en) | A kind of detection device for near-infrared brain scans | |
| JP4739878B2 (en) | Cerebral blood flow measuring device | |
| Baldini et al. | Optical-fiber medical sensors | |
| CN209899401U (en) | Four-wavelength combined noninvasive glucometer | |
| WO2004006759A1 (en) | Method for optical measurement of multiple physiologic parameters |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |