CN112165932A - Temperature-sensitive cosmetic - Google Patents
Temperature-sensitive cosmetic Download PDFInfo
- Publication number
- CN112165932A CN112165932A CN201980035396.4A CN201980035396A CN112165932A CN 112165932 A CN112165932 A CN 112165932A CN 201980035396 A CN201980035396 A CN 201980035396A CN 112165932 A CN112165932 A CN 112165932A
- Authority
- CN
- China
- Prior art keywords
- acid
- cosmetic
- temperature
- tranexamic acid
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 68
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 59
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 150000007522 mineralic acids Chemical class 0.000 claims abstract description 16
- 150000007524 organic acids Chemical class 0.000 claims abstract description 16
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 229920005862 polyol Polymers 0.000 claims description 15
- 150000003077 polyols Chemical class 0.000 claims description 15
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 5
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 229940105990 diglycerin Drugs 0.000 claims description 4
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 229940100485 methyl gluceth-10 Drugs 0.000 claims description 3
- 229940113120 dipropylene glycol Drugs 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
- 238000001556 precipitation Methods 0.000 abstract description 18
- 230000035807 sensation Effects 0.000 abstract description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 description 44
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 44
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 44
- 229920006037 cross link polymer Polymers 0.000 description 32
- -1 polyethylene Polymers 0.000 description 32
- 229920001296 polysiloxane Polymers 0.000 description 23
- 229940008099 dimethicone Drugs 0.000 description 22
- 239000003921 oil Substances 0.000 description 19
- 239000000839 emulsion Substances 0.000 description 18
- 235000019198 oils Nutrition 0.000 description 18
- 229920002379 silicone rubber Polymers 0.000 description 14
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 10
- 239000003995 emulsifying agent Substances 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 8
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 8
- 229910000271 hectorite Inorganic materials 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 7
- 230000001804 emulsifying effect Effects 0.000 description 7
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 239000003125 aqueous solvent Substances 0.000 description 5
- 239000002734 clay mineral Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 239000003093 cationic surfactant Substances 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 4
- 229940099549 polyglycerin-3 Drugs 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 206010016334 Feeling hot Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000010495 camellia oil Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- YZUUTMGDONTGTN-UHFFFAOYSA-N nonaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCO YZUUTMGDONTGTN-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000003916 acid precipitation Methods 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- BWNMWDJZWBEKKJ-UHFFFAOYSA-M benzyl-docosyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 BWNMWDJZWBEKKJ-UHFFFAOYSA-M 0.000 description 2
- NXQZAIRGRWDONB-UHFFFAOYSA-M benzyl-ethyl-methyl-octadecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(CC)CC1=CC=CC=C1 NXQZAIRGRWDONB-UHFFFAOYSA-M 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 description 2
- 239000004664 distearyldimethylammonium chloride (DHTDMAC) Substances 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- GULIJHQUYGTWSO-UHFFFAOYSA-N dodecyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCC GULIJHQUYGTWSO-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- KEMQGTRYUADPNZ-UHFFFAOYSA-N heptadecanoic acid Chemical compound CCCCCCCCCCCCCCCCC(O)=O KEMQGTRYUADPNZ-UHFFFAOYSA-N 0.000 description 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- ISYWECDDZWTKFF-UHFFFAOYSA-N nonadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCCC(O)=O ISYWECDDZWTKFF-UHFFFAOYSA-N 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 239000001993 wax Chemical class 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- GHEZBHAGHAJHIT-UHFFFAOYSA-N 2,2-dihydroxyethyl-di(docosyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[NH+](CC(O)O)CCCCCCCCCCCCCCCCCCCCCC GHEZBHAGHAJHIT-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 description 1
- ODMZDMMTKHXXKA-QXMHVHEDSA-N 8-methylnonyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCCCCCC(C)C ODMZDMMTKHXXKA-QXMHVHEDSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241001237961 Amanita rubescens Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- DUFKCOQISQKSAV-UHFFFAOYSA-N Polypropylene glycol (m w 1,200-3,000) Chemical compound CC(O)COC(C)CO DUFKCOQISQKSAV-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 101000611641 Rattus norvegicus Protein phosphatase 1 regulatory subunit 15A Proteins 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- CFRNDJFRRKMHTL-UHFFFAOYSA-N [3-octanoyloxy-2,2-bis(octanoyloxymethyl)propyl] octanoate Chemical compound CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC CFRNDJFRRKMHTL-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000004848 alkoxyethyl group Chemical group 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 1
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- FWLORMQUOWCQPO-UHFFFAOYSA-N benzyl-dimethyl-octadecylazanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 FWLORMQUOWCQPO-UHFFFAOYSA-N 0.000 description 1
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 description 1
- LVSGFWNKVBQBOW-UHFFFAOYSA-M benzyl-ethyl-hexadecyl-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(CC)CC1=CC=CC=C1 LVSGFWNKVBQBOW-UHFFFAOYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 description 1
- 229960000228 cetalkonium chloride Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- RRGHSHZGBRAVGS-UHFFFAOYSA-M diethyl-hexadecyl-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(CC)CC RRGHSHZGBRAVGS-UHFFFAOYSA-M 0.000 description 1
- DMKRHCDMCCRWGG-UHFFFAOYSA-M diethyl-icosyl-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCC[N+](C)(CC)CC DMKRHCDMCCRWGG-UHFFFAOYSA-M 0.000 description 1
- OGROBAAGXAWUPN-UHFFFAOYSA-M diethyl-methyl-octadecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(CC)CC OGROBAAGXAWUPN-UHFFFAOYSA-M 0.000 description 1
- NCQWPDAAKWLRTD-UHFFFAOYSA-M diethyl-methyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(CC)CC NCQWPDAAKWLRTD-UHFFFAOYSA-M 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- AJUWSIZSFHYZIQ-UHFFFAOYSA-M docosyl-diethyl-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(CC)CC AJUWSIZSFHYZIQ-UHFFFAOYSA-M 0.000 description 1
- RRTYRGMBMQXLSX-UHFFFAOYSA-M docosyl-ethyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)CC RRTYRGMBMQXLSX-UHFFFAOYSA-M 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 description 1
- RXHDXDIEHWVFOC-UHFFFAOYSA-M ethyl-dimethyl-octadecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC RXHDXDIEHWVFOC-UHFFFAOYSA-M 0.000 description 1
- VIPWBDNNTAIYFL-UHFFFAOYSA-M ethyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC VIPWBDNNTAIYFL-UHFFFAOYSA-M 0.000 description 1
- KSCHLNBLIAOANF-UHFFFAOYSA-M ethyl-hexadecyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC KSCHLNBLIAOANF-UHFFFAOYSA-M 0.000 description 1
- KBIHAGSFLJPXHF-UHFFFAOYSA-M ethyl-icosyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCC[N+](C)(C)CC KBIHAGSFLJPXHF-UHFFFAOYSA-M 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- MRAPAFWHXSJNRN-UHFFFAOYSA-M icosyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCC[N+](C)(C)C MRAPAFWHXSJNRN-UHFFFAOYSA-M 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 229940093629 isopropyl isostearate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000005527 methyl sulfate group Chemical group 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- QWPNJOHZHSJFIY-UHFFFAOYSA-N octyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCC QWPNJOHZHSJFIY-UHFFFAOYSA-N 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000013500 performance material Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920005903 polyol mixture Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910000275 saponite Inorganic materials 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 description 1
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 description 1
- AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/45—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The purpose of the present invention is to provide a temperature-sensitive cosmetic which exhibits an excellent effect of imparting a temperature-sensitive sensation, and in which tranexamic acid is sufficiently dissolved to sufficiently suppress precipitation over time. The present invention relates to a temperature-sensitive cosmetic characterized by containing tranexamic acid, water in an amount of 5 times or less by mass of the tranexamic acid, a polyhydric alcohol, and an organic acid and/or an inorganic acid.
Description
Technical Field
The present invention relates to a temperature-sensitive cosmetic that imparts a temperature-sensitive feel when applied to the skin. More particularly, the present invention relates to a temperature-sensitive cosmetic composition which can stably contain tranexamic acid and has a good feeling of use.
Background
Generally, it is known that imparting a moderate temperature sensation to the skin promotes blood circulation of the skin, increases metabolism, and provides a blood color improving effect, a relaxing effect, a fatigue recovery effect, and the like. Therefore, these effects are expected to be expected to allow the blending of a heat-generating substance into a cosmetic. As a heat-generating substance to be blended in cosmetics, a moisturizing agent such as a polyhydric alcohol, zeolite, a metal salt, a metal oxide, or the like has been widely used. These are all hygroscopic and generate heat when they come into contact with moisture on the skin, thereby giving a feeling of warmth to the skin.
Patent document 1 proposes a polyol-in-oil type detergent prepared by emulsifying a polyol with a specific nonionic surfactant, in order to obtain an appropriate viscosity and an excellent effect of imparting a warm feeling.
In addition, patent document 2 is expected to produce various effects by giving a warm feeling to the skin, and a leave-on type warm-feeling cosmetic that does not require rinsing after application is also developed.
In general, in a temperature-sensitive cosmetic, when water is contained, heat is generated during storage, and a sufficient temperature-sensitive property cannot be obtained in application, and therefore, a nonaqueous system is preferable. On the other hand, a large amount of water is required to dissolve tranexamic acid which is incorporated into an external preparation for skin as a whitening agent. Therefore, it is difficult to incorporate tranexamic acid into a temperature-sensitive cosmetic. Further, tranexamic acid has a strong crystallinity and is problematic in that it is precipitated and solidified with time, and therefore, in a cosmetic containing tranexamic acid, it is necessary to sufficiently suppress precipitation with time.
Documents of the prior art
Patent document
Patent document 1: japanese patent application laid-open No. 2014-37404
Patent document 2: japanese patent laid-open publication No. 2016 & 193841
Disclosure of Invention
Problems to be solved by the invention
The purpose of the present invention is to provide a temperature-sensitive cosmetic composition which exhibits an excellent effect of imparting a temperature-sensitive sensation and which stably contains tranexamic acid.
Means for solving the problems
The present inventors have made extensive studies and, as a result, have found that the above object can be achieved by blending tranexamic acid, water in an amount of 5 times or less the amount of tranexamic acid, a polyhydric alcohol, and an organic acid and/or an inorganic acid, and have completed the present invention.
That is, the present invention provides a temperature-sensitive cosmetic comprising:
tranexamic acid, tranexamic acid,
Water in an amount of 5 times or less by mass of tranexamic acid,
A polyol, and
organic acids and/or inorganic acids.
ADVANTAGEOUS EFFECTS OF INVENTION
The present invention, by adopting the above-described configuration, can provide a temperature-sensitive cosmetic which exhibits an excellent effect of imparting a temperature-sensitive sensation, and in which tranexamic acid is sufficiently dissolved to sufficiently suppress precipitation over time.
Detailed Description
The temperature-sensitive cosmetic composition of the present invention is characterized by containing tranexamic acid, water in an amount of 5 times or less by mass of the tranexamic acid, a polyhydric alcohol, and an organic acid and/or an inorganic acid as essential components. The present invention will be described in detail below.
< tranexamic acid >
Tranexamic acid used in the temperature sensitive cosmetic of the present invention is trans-4-aminomethylcyclohexanecarboxylic acid, and is a known agent as a cosmetic compounding ingredient. In many cases, it is blended as a skin roughness improving agent, a whitening agent, or the like.
The amount of tranexamic acid added to the cosmetic of the present invention is 0.1 to 5% by mass, preferably 1.0 to 3.0% by mass, based on the total amount of the cosmetic. If the amount of tranexamic acid added is less than 0.1 mass%, a sufficient drug effect cannot be obtained, and if it exceeds 5 mass%, precipitation is likely to occur, and in addition, it is not preferable in that the amount of water required for dissolution increases, and the temperature sensation decreases.
< water >)
In the temperature-sensitive cosmetic composition of the present invention, water (ion-exchanged water, purified water, natural water, or the like) may be added as an aqueous solvent for tranexamic acid within a range that does not impair the usability or stability of the cosmetic composition. Among these, since the temperature-sensitive effect tends to be reduced when the aqueous solvent is present, the amount of the aqueous solvent to be added should be suppressed to 10% by mass or less, preferably 8% by mass or less, and more preferably 5% by mass or less, relative to the total amount of the temperature-sensitive cosmetic. Therefore, in the warm-feeling cosmetic preparation of the present invention, the amount of water to be added is preferably 5 times by mass or less, more preferably 2 times by mass or more and 5 times by mass or less of the amount of tranexamic acid to be added, from the viewpoint of sufficiently dissolving tranexamic acid in the aqueous solvent and obtaining a warm feeling.
< polyol >
The polyhydric alcohol used in the temperature-sensitive cosmetic of the present invention is not limited to a component that imparts a temperature-sensitive feel when applied to the skin, and examples thereof include: glycerin, diglycerin, polyglycerol, 1, 3-butanediol, ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol (PEG-8, etc.), polypropylene glycol, polyethylene glycol-polypropylene glycol, methyl gluceth-10 (polyoxyethylene methyl glucoside), trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, hexanediol, 1, 2-pentanediol, trehalose, and the like.
From the viewpoint of solubility of tranexamic acid in water, glycerin is preferably used, and dipropylene glycol, diglycerin, sorbitol and the like are preferably appropriately blended and used. As an example, it is preferable to contain glycerin and 1 or 2 or more selected from dipropylene glycol, diglycerin, sorbitol, methyl gluceth-10 and 1, 3-butanediol.
By blending the polyhydric alcohol, a warming effect can be produced to introduce the skin with a bright and good bloody color, and the moisture on the skin surface can be prevented from evaporating by the high moisturizing effect, thereby preventing makeup removal due to dryness.
The amount of the polyol to be blended in the cosmetic of the present invention is 20% by mass or more, preferably 20 to 80% by mass, and more preferably 30 to 70% by mass, based on the total amount of the cosmetic. If the amount of the polyol to be blended is less than 20% by mass, the feeling of warmth at the time of use cannot be sufficiently obtained.
< organic acid and/or inorganic acid >
The organic acid and/or inorganic acid used in the temperature sensitive cosmetic of the present invention is an organic acid or inorganic acid used for ordinary pH adjustment in skin external preparations such as cosmetics.
In the present invention, there are included: malic acid, citric acid, lactic acid, phosphoric acid, hydrochloric acid, and the like, preferably acids in a liquid state at room temperature, and particularly preferably lactic acid and phosphoric acid. In the present invention, it is preferable that the pH of the cosmetic is adjusted to 3.5 or more and 5.5 or less by using the organic acid and/or the inorganic acid from the viewpoint of suppressing the precipitation of tranexamic acid and imparting a warm feeling. In the present invention, the pH value is a value measured using HORIBA pH METER F-21 (manufactured by HORIBA, Ltd.). However, the pH can also be measured using other commonly used commercially available pH values.
The organic acid and/or inorganic acid in the cosmetic of the present invention may be used in combination of one or more than 2 kinds. The amount of the organic acid and/or inorganic acid is about 0.1 to 3.0% by mass based on the total amount of the cosmetic. The blending amount is appropriately determined depending on the pH of the cosmetic to be prepared, and in short, the blending amount is determined so that the pH of the cosmetic is 5.5 or less.
The temperature-sensitive cosmetic of the present invention can be prepared as an aqueous system containing no oil, emulsifier, etc. However, an oil component, an oil phase thickener, an emulsifier, and the like may be appropriately blended to prepare an emulsion for the purpose of usability or imparting a desired performance. When the emulsion is prepared, it is preferably prepared as a water-in-oil emulsion from the viewpoint of usability such as a sticky feeling and emulsion stability.
When the temperature-sensitive cosmetic of the present invention is prepared as a water-in-oil emulsion, an oil phase thickener, an emulsifier, and a polyether-modified silicone, which are listed below, may be further added to improve emulsion stability and a feeling of use.
< oil phase thickener >
The oil phase thickener used in the temperature-sensitive cosmetic of the present invention is one that can impart viscosity to an oil phase. For example, a cross-linking type silicone elastomer, dextrin fatty acid ester, hydrophobically modified polysaccharide, fatty acid, wax, or the like can be used. In the present invention, by blending a crosslinking silicone elastomer, a smooth feeling in use without stickiness can be improved.
The crosslinked silicone elastomer is a silicone elastomer (silicone elastomer) obtained by three-dimensionally crosslinking polydimethylsiloxane, and includes emulsifying properties and non-emulsifying properties.
The emulsifying crosslinked silicone elastomer is not particularly limited, and examples thereof include: crosslinked polyoxyethylene methylpolysiloxane, alkyl group-containing crosslinked polyoxyethylene methylpolysiloxane, crosslinked polyglycerol-modified silicone, alkyl group-containing crosslinked polyglycerol-modified silicone, and the like. These emulsifying crosslinked silicone elastomers are commercially available in the form of a swollen product that swells in various oil components such as silicone oil, mineral oil, triisooctanoic acid glyceride, and squalane. Specific examples thereof include the following.
Examples of the polyoxyethylene methylpolysiloxane crosslinked polymer include KSG-210 (PEG-10/15/polydimethylsiloxane crosslinked polymer, manufactured by shin-Etsu chemical Co., Ltd.), 9011 silicone elastomer blend (PEG-12/polydimethylsiloxane crosslinked polymer, manufactured by Dow Corning Toray Co., Ltd.), and the like.
Examples of the alkyl group-containing polyoxyethylene methylpolysiloxane crosslinked polymer include: KSG-310 (PEG-15/lauryl dimethicone crosspolymer), KSG-320 (PEG-15/lauryl dimethicone crosspolymer), KSG-330 (PEG-15/lauryl dimethicone crosspolymer), KSG-340 (PEG-10/lauryl dimethicone crosspolymer, PEG-15/lauryl dimethicone crosspolymer) (manufactured by shin-Etsu chemical Co., Ltd.).
Examples of the polyglycerol-modified silicone crosslinked polymer include KSG-710 (polydimethylsiloxane/polyglycerol-3 crosslinked polymer, manufactured by shin-Etsu chemical Co., Ltd.).
Examples of the alkyl group-containing polyglycerin-modified silicone crosslinked polymer include: KSG-810 (lauryl dimethicone/polyglycerin-3 crosspolymer), KSG-820 (lauryl dimethicone/polyglycerin-3 crosspolymer), KSG-830 (lauryl dimethicone/polyglycerin-3 crosspolymer), KSG-840 (lauryl dimethicone/polyglycerin-3 crosspolymer) (manufactured by shin-Etsu chemical Co., Ltd.).
The non-emulsifying crosslinked silicone elastomer is not particularly limited, and examples thereof include: methyl polysiloxane crosspolymer, methyl phenyl polysiloxane crosspolymer, vinyl dimethicone/lauryl dimethicone crosspolymer, lauryl dimethicone alkoxyethyl dimethicone/divinyl dimethicone crosspolymer, alkyl (C30-45) cetearyl dimethicone crosspolymer, and the like. These non-emulsifying crosslinked silicone elastomers are commercially available in the form of a swollen product that swells in various oil components such as silicone oil, mineral oil, glyceryl triisooctanoate, and squalane. Specific examples thereof include the following.
As the methylpolysiloxane crosslinked polymer, there can be mentioned: polydimethylsiloxane cross-linked polymers such as 9040 silicone elastomer blend, 9041 silicone elastomer blend, 9045 silicone elastomer blend and EL-8040ID silicone organic blend (manufactured by Dow Corning Toray Co., Ltd.), polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymers such as KSG-15, KSG-16 and KSG-1610 (manufactured by shin-Etsu chemical Co., Ltd.), vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane cross-linked polymers such as KSP-100 (manufactured by shin-Etsu chemical Co., Ltd.), polymethylsilsesquioxane such as PEARL 150KA (manufactured by MoTOSE Performance Materials Co., Ltd.), and the like.
Examples of the methylphenylpolysiloxane crosslinked polymer include a polydimethylsiloxane/phenylpolydimethylsiloxane crosslinked polymer such as KSG-18A (polydimethylsiloxane/phenylvinyl polydimethylsiloxane crosslinked polymer, manufactured by shin-Etsu chemical Co., Ltd.).
Examples of vinyl dimethicone/lauryl dimethicone crosspolymer include: KSG-41A, KSG-42A, KSG-43, KSG-44 (manufactured by shin-Etsu chemical Co., Ltd.).
Examples of the swollen product of the lauryl polydimethylsiloxyethyl dimethicone/bisvinyl dimethicone crosspolymer include KSG-042Z, KSG-045Z (manufactured by shin-Etsu chemical Co., Ltd.).
Examples of the alkyl (C30-45) cetearyl dimethicone crosspolymer include VELVESIL 125 and VELVESIL 034 (manufactured by Momentive Performance Materials Co., Ltd.).
The cross-linked polymer of cetearyl dimethicone may be, for example, VELVESIL DM (manufactured by Momentive Performance Materials).
In the present invention, one or 2 or more kinds selected from the above-mentioned crosslinking silicone elastomers may be used in combination. The amount of the oil phase thickener in the cosmetic of the present invention is 0.5 to 15% by mass, preferably 1.0 to 12% by mass, and more preferably 1.5 to 10% by mass, based on the total amount of the cosmetic. When the amount is less than 0.5% by mass, a sticky feeling may be generated, and when it exceeds 15% by mass, it may be difficult to produce a stable cosmetic.
< emulsifier >
The emulsifier used in the temperature-sensitive cosmetic of the present invention is a relatively high lipophilicity and can exert an emulsion stabilizing effect of an aqueous component and an oily component highly blended with a polyhydric alcohol. In the present invention, polyether-modified silicone or organically modified clay mineral having specific properties can be preferably used.
The polyether-modified silicone as the emulsifier of the present invention has an HLB of 8.0 or less and a viscosity of 10000mm at 25 ℃2More than s, preferably 15000mm2A thickness of 20000mm or more2More than s. If the viscosity is less than 10000mm2And/s, good emulsion stability cannot be obtained.
Specific examples of the polyether-modified silicone include PEG/PPG (Poly Propylene Glycol) -19/19 polydimethylsiloxane (trade name "BY 11-030", HLB: 3, and viscosity of 30000mm2S; manufactured by Dow Corning Toray corporation), and the like.
The organically modified clay mineral usable as an emulsifier in the present invention is one of colloidal hydrous aluminum silicates having a three-layer structure, and a clay mineral represented by the following general formula (1) can be modified with a quaternary ammonium salt type cationic surfactant.
(X,Y)2-3(Si,Al)4O10(OH)2Z1/3·nH2O (1)
In the formula, X is Al, Fe (III), Mn (III) or Cr (III), Y is Mg, Fe (II), Ni, Zn or Li, and Z is K, Na or Ca.
Specifically, the cationic surfactant can be obtained by treating clay minerals such as natural or synthetic smectites (in this case, those in which the (OH) group in the formula is substituted with fluorine) such as montmorillonite, saponite and hectorite (commercially available products such as magnesium aluminum silicate, Kunipia and synthetic hectorite), and synthetic micas (commercially available products such as Dimonite and manufactured by TOPY INDUSTRIES) known under the name of sodium silicate mica, sodium mica or laponite.
The quaternary ammonium salt cationic surfactant used here is represented by the following general formula (2).
In the formula, R1Represents C10-22 alkyl or benzyl, R2Nail for indicationA group or C10-22 alkyl group, R3And R4Represents an alkyl group or a hydroxyalkyl group having 1 to 3 carbon atoms, and X represents a halogen atom or a methyl sulfate residue.
Examples of the quaternary ammonium salt cationic surfactant include: dodecyl trimethyl ammonium chloride, myristyl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, arachidyl trimethyl ammonium chloride, behenyl trimethyl ammonium chloride, myristyl dimethyl ethyl ammonium chloride, cetyl dimethyl ethyl ammonium chloride, stearyl dimethyl ethyl ammonium chloride, arachidyl dimethyl ethyl ammonium chloride, behenyl dimethyl ethyl ammonium chloride, myristyl diethyl methyl ammonium chloride, cetyl diethyl methyl ammonium chloride, stearyl diethyl methyl ammonium chloride, arachidyl diethyl methyl ammonium chloride, behenyl diethyl methyl ammonium chloride, benzyl dimethyl myristyl ammonium chloride, benzyl dimethyl cetyl ammonium chloride, benzyl dimethyl stearyl ammonium chloride, benzyl dimethyl behenyl ammonium chloride, benzyl methyl ethyl cetyl ammonium chloride, benzyl methyl ethyl stearyl ammonium chloride, benzyl dimethyl behenyl ammonium chloride, benzyl dimethyl lauryl ammonium chloride, benzyl methyl ethyl stearyl ammonium chloride, Dibehenyl dihydroxyethyl ammonium chloride, a bromide equivalent thereto, dipalmitoylpropylethylammonium methylsulfate, and the like. In the practice of the present invention, one or more than 2 of these are arbitrarily selected.
Representative examples of the organically modified clay mineral include: dimethyl distearyl ammonium hectorite (distearyl dimethyl ammonium hectorite), dimethyl alkyl ammonium hectorite, benzyl dimethyl stearyl ammonium hectorite, distearyl dimethyl ammonium chloride-treated aluminum magnesium silicate, and the like. Among them, dimethyl distearyl ammonium hectorite is particularly preferable. Commercially available products include Bentonine 27 (benzyldimethylstearylammonium chloride-treated hectorite, manufactured by Elementis Japan) and Bentonine 38VCG (distearyldimethylammonium chloride-treated hectorite, manufactured by Elementis Japan).
The amount of the emulsifier blended in the cosmetic of the present invention is 0.1 to 5% by mass, preferably 0.5 to 4% by mass, and more preferably 0.5 to 3.5% by mass based on the total amount of the cosmetic. When the amount is less than 0.1% by mass, the emulsion stability tends to be poor, and when it exceeds 5% by mass, the emulsion is not preferable in that a sticky feeling may be caused by the emulsifier.
< polyether modified Silicone >)
In the invention, the HLB is below 8.0 and the viscosity at 25 ℃ is less than 10000mm2The polyether modified organosilicon of/s can further improve the emulsion stability. Among them, those having no alkyl chain in the side chain and having a polyoxyalkylene group in the side chain of a linear or branched silicone skeleton are preferable.
Specific examples of the polyether-modified silicone having a linear silicone skeleton include: PEG-3 Dimethicone (trade name "KF-6015", HLB 4.5, viscosity 150 mm)2S; manufactured by shin-Etsu chemical Co., Ltd.), PEG-9 methyl ether polydimethylsiloxane (trade name "KF-6016", HLB 4.5, viscosity 150mm2S; manufactured by shin-Etsu chemical Co., Ltd.), PEG-10 polydimethylsiloxane (trade name "KF-6017P", HLB 4.5, viscosity 850mm2S; manufactured by shin-Etsu chemical Co., Ltd.), PEG-12 polydimethylsiloxane (trade name "SH 3772M", HLB 6, viscosity 1050mm2(ii)/s, trade name "SH 3773M", HLB (8), viscosity 650mm2(ii)/s, trade name "SH 3775M", HLB 5, viscosity 1600mm2S; these are all manufactured by Dow Corning Toray Co., Ltd.), PEG/PPG-20/22 butyl ether polydimethylsiloxane (trade name "KF-6012", HLB 7.0, viscosity 1600mm2S; shin-Etsu chemical Co., Ltd.) and the like.
Specific examples of the polyether-modified silicone having a branched silicone skeleton include: PEG-9 Dimethylsilalkoxyethyl polydimethylsiloxane (trade name: KF-6028, HLB: 4, viscosity 900 mm)2S; manufactured by shin-Etsu chemical Co., Ltd.), lauryl PEG-9 Dimethylsilyloxyalkylethyl polydimethylsiloxane (trade name "KF-6038", HLB 3, viscosity 700mm2S; manufactured by shin-Etsu chemical Co., Ltd.), cetyl PEG/PPG-10/1 polydimethylsiloxane (trade name "KF-6048", HLB 3.5, viscosity 2700mm2S; shin-Etsu chemical Co., Ltd.) and the like.
Among the above polyether-modified silicones, PEG-10 polydimethylsiloxane or PEG-9 polydimethylsiloxyethyl polydimethylsiloxane is preferably used from the viewpoint of obtaining good emulsion stability.
In the present invention, one or 2 or more selected from the polyether-modified silicones can be used in combination.
The amount of polyether-modified silicone blended in the cosmetic of the present invention is 0.1 to 10 mass%, preferably 0.3 to 6 mass%, and more preferably 1 to 4.5 mass% with respect to the total amount of the cosmetic. When the cosmetic of the present invention is prepared as a two-layer cosmetic, the amount of polyether-modified silicone may be 0.1% by mass or less.
< other ingredients >
The warm cosmetic of the present invention can be blended with an oil component to improve the feeling of use when applied to the skin. The oil component is not particularly limited as long as it can be used in a usual cosmetic.
Examples thereof include: linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, almond oil, cinnamon oil, jojoba oil, grape oil, sunflower oil, almond oil, rapeseed oil, sesame oil, wheat germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil and other oils; fatty acids such as heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, isostearic acid, oleic acid, linoleic acid, and arachidonic acid; esters such as pentaerythritol tetraoctanoate, cetyl octanoate, hexyl laurate, isopropyl myristate, octyl myristate, dodecyl palmitate, octyl palmitate, isopropyl isostearate, octyl isopalmitate, isodecyl oleate, cetyl ethylhexanoate, and the like; hydrocarbons such as liquid paraffin, squalane, squalene, olefin oligomers, hydrogenated polydecene, paraffin, isoparaffin, octane, decane, dodecane, isododecane, hexadecane, and isohexadecane; higher alcohols such as octanol, isostearyl alcohol, oleyl alcohol and the like; chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane, and silicone oils such as octylmethicone. These oils may be used alone or in combination of two or more.
When the oil component is blended, it is preferably 10 to 50% by mass, more preferably 15 to 40% by mass, and still more preferably 15 to 30% by mass, based on the total amount of the cosmetic.
In addition to the above components, other components used in usual cosmetics, for example, a powder component, an ultraviolet protective agent, various aqueous solvents, a masking agent, a sugar, an amino acid, an organic amine, a stabilizer, a skin nutrient, an antioxidant aid, a perfume, and the like may be appropriately blended as necessary in the warm-feeling cosmetic of the present invention within a range not to impair the effects of the present invention.
When the temperature-sensitive cosmetic of the present invention is prepared as an emulsion, the average emulsion particle size of water droplets constituting the emulsion is preferably 10 μm or less, 5 μm or less, or 3 μm or less. By reducing the average emulsion particle size, the emulsion stability is excellent.
The temperature-sensitive cosmetic of the present invention is excellent in stability even when a water-soluble drug is blended, and has good feeling of use without stickiness even when a humectant is highly blended. Therefore, the temperature-sensitive cosmetic of the present invention can be widely applied to cosmetics, and can be provided in any form such as a lotion, a skin lotion, an emulsion, a beauty lotion, a cream, a massage cosmetic, a sunscreen cosmetic, a foundation, a pack, a lipstick, a blusher, an eye shadow, and the like.
The hardness of the temperature-sensitive cosmetic of the present invention measured at 25 ℃ using a rheometer (11.3 mm. phi., 10mm needle penetration) can be 6 or more, preferably 8 or more, and more preferably 10 or more. In addition, wax or the like may be used in combination to make a paste. The emulsion cosmetic of the present invention having such hardness is excellent in stability, and when filled into a bottle container, for example, does not flow and retains an appropriate hardness.
The temperature-sensitive cosmetic of the present invention can be produced by a conventional method. For example, tranexamic acid is dissolved in a small amount of water under a low pH environment, and then a humectant is added. In the case of preparing a water-in-oil emulsion, the aqueous phase component and the oil phase component are stirred and mixed to prepare a uniform aqueous phase portion and an oil phase portion, respectively, and the aqueous phase portion is added to the oil phase portion and stirred and mixed to prepare the emulsion.
Examples
The present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.
< Effect of polyol on solubility of tranexamic acid >
The change in the amount of water required to dissolve tranexamic acid when blended with the polyol mixture is shown in table 1 below.
Evaluation criteria
A: is fully dissolved
B: a part of the residue remained undissolved
C: hardly dissolved
[ Table 1]
Sample No. 1 | Sample No. 2 | Sample No. 3 | Sample No. 4 | Sample No. 5 | |
Ion exchange water | 15 | 22 | 28 | 30 | 33 |
Tranexamic acid | 2 | 2 | 2 | 2 | 2 |
Glycerol | - | 25 | 25 | 25 | 25 |
Polyethylene glycol 400 | - | 10 | 10 | 10 | 10 |
1, 3-butanediol | - | 8 | 8 | 8 | 8 |
Dipropylene glycol | - | 9 | 9 | 9 | 9 |
Dissolution | A | C | B~C | B | A |
In the case of not blending a polyol (sample 1), 2g of tranexamic acid was sufficiently dissolved in 15g of water, but in the case of blending a polyol, even if the amount of water was increased to 22g to 30g, tranexamic acid was not dissolved (samples 2 to 4), and in order to sufficiently dissolve it, the amount of water had to be increased to 33g (sample 5). On the other hand, in sample 5, tranexamic acid was sufficiently dissolved, but a warm feeling was not obtained.
< influence of humectant on tranexamic acid precipitation >
Tranexamic acid has a strong crystallinity, and is precipitated and solidified with time, which is a problem. Samples were prepared using the components shown in table 2 below, and the effect of the polyol on tranexamic acid precipitation was evaluated. That is, a fixed amount of polyol was added to an aqueous solution obtained by dissolving a fixed amount (here, 2g) of tranexamic acid in 7.5 times the amount of water to prepare samples, and then the appearance of each sample at room temperature was observed. The results are shown in Table 2.
Evaluation criteria
A: no precipitation was observed.
B: precipitation was slightly observed.
C: more precipitation was observed.
[ Table 2]
As shown in Table 2, the precipitation of tranexamic acid from the aqueous tranexamic acid solution occurred with time depending on the kind of the polyol to be blended. In the case of blending glycerol (samples 6 to 8), precipitation of tranexamic acid was not observed even when the amount of glycerol blended was increased, but precipitation of tranexamic acid was observed in the case of blending polyethylene glycol 400, 1, 3-butanediol, dipropylene glycol, and methyl glucitol polyether-10 alone to a tranexamic acid aqueous solution.
From the results shown in table 2, it is estimated that the precipitation of the tranexamic acid aqueous solution is suppressed by the addition of glycerin.
[ Effect of organic acid/inorganic acid on warming cosmetics containing tranexamic acid ]
Next, the following samples 13 to 21 were prepared by blending the components shown in Table 3, and the influence of the blending of an organic acid/an inorganic acid on the dissolution of tranexamic acid and the feeling of warmth was evaluated. Specifically, among the components shown in table 3, tranexamic acid was dissolved in an organic acid and/or an inorganic acid and water, and a polyol was added thereto. The evaluation method is as follows.
Evaluation relating to the dissolution of Tranexamic Acid (TA)
After each sample was prepared, the appearance of each sample at room temperature was observed.
Evaluation criteria
A: no precipitation was observed.
B: precipitation was slightly observed.
C: more precipitation was observed.
Evaluation relating to temperature sensation
The prepared test specimens were subjected to actual use tests by 10 professional functional inspectors. Specifically, the prepared samples were applied to the faces of 10 functional examiners, and the temperature sensation was evaluated according to the following criteria.
Evaluation criteria
A: 8 or more of the 10 were evaluated to have excellent temperature feeling when used.
B: 4 to 7 out of 10 were evaluated to have excellent temperature feeling in use.
C: 3 or less of them evaluated excellent in temperature feeling when used
[ Table 3]
As shown in Table 3, in samples 13 and 14 in which no polyol was blended, 2g of tranexamic acid was sufficiently dissolved in 15g of water. Further, from the results of table 1 above, when a polyhydric alcohol was added to the tranexamic acid solution, if the amount of water was not increased, the tranexamic acid was not dissolved, but as shown in sample 15 of table 3, the pH was set to 5.5 or less by adding an organic acid/inorganic acid, and 25g of glycerin was added, but the tranexamic acid was sufficiently dissolved.
Therefore, the temperature-sensitive effect is improved by reducing the amount of water to be added based on the base of sample 15 and adjusting the pH, and as a result, samples having good dissolution of TA and temperature-sensitive feeling as shown in samples 17, 18, 20, and 21 are obtained.
Incidentally, since precipitation was observed in samples 16 and 19, pH measurement and evaluation of the temperature sensation were not performed.
In sample 19, polyethylene glycol 400 was added as a temperature-sensitive polyol, which inhibited the dissolution of tranexamic acid. Therefore, although polyethylene glycol 400 has a high effect of imparting warmth, it is generally used in a warmth-sensitive cosmetic, but tends to significantly inhibit the dissolution of tranexamic acid.
The following examples are formulations of the temperature sensitive cosmetic of the present invention. The application examples of the temperature-sensitive cosmetic of the present invention are not limited to the following formulation examples.
The above formulation has an excellent effect of imparting warmth to the skin, and does not cause the precipitation of tranexamic acid with time even after the passage of time, thereby providing a warmth-imparting whitening cream.
The formula has excellent effect of imparting warmth, and the mild whitening double-layer emollient water can be obtained without precipitation of tranexamic acid over time even after the elapse of time.
Claims (3)
1. A temperature-sensitive cosmetic comprising:
tranexamic acid, tranexamic acid,
Water in an amount of 5 times or less by mass of tranexamic acid,
A polyol, and
organic acids and/or inorganic acids.
2. The cosmetic according to claim 1, wherein the organic acid and/or inorganic acid is 1 or 2 or more selected from lactic acid, phosphoric acid and citric acid.
3. The cosmetic according to claim 1, wherein the polyhydric alcohol comprises glycerin and 1 or 2 or more selected from dipropylene glycol, diglycerin, sorbitol, methyl gluceth-10, and 1, 3-butanediol.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018020619 | 2018-05-29 | ||
JPPCT/JP2018/020619 | 2018-05-29 | ||
PCT/JP2019/020585 WO2019230579A1 (en) | 2018-05-29 | 2019-05-24 | Warm-sensation cosmetic preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112165932A true CN112165932A (en) | 2021-01-01 |
Family
ID=68697006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980035396.4A Pending CN112165932A (en) | 2018-05-29 | 2019-05-24 | Temperature-sensitive cosmetic |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP7299886B2 (en) |
CN (1) | CN112165932A (en) |
TW (1) | TW202002943A (en) |
WO (1) | WO2019230579A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11642324B1 (en) | 2022-03-01 | 2023-05-09 | Bio 54, Llc | Topical tranexamic acid compositions and methods of use thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006008574A (en) * | 2004-06-25 | 2006-01-12 | Pola Chem Ind Inc | Non-aqueous foam cosmetic imparting warm sensation |
JP2010229100A (en) * | 2009-03-27 | 2010-10-14 | Shiseido Co Ltd | External preparation for skin |
CN102186454A (en) * | 2008-10-15 | 2011-09-14 | 株式会社资生堂 | Skin preparation composition for external use |
CN104717960A (en) * | 2012-10-17 | 2015-06-17 | 考司美德制药株式会社 | Hyaluronic acid gel and method for producing same |
JP2017128524A (en) * | 2016-01-19 | 2017-07-27 | ポーラ化成工業株式会社 | Gelatinous cosmetics |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011195460A (en) * | 2010-03-17 | 2011-10-06 | Shiseido Co Ltd | External preparation for skin |
-
2019
- 2019-05-24 CN CN201980035396.4A patent/CN112165932A/en active Pending
- 2019-05-24 WO PCT/JP2019/020585 patent/WO2019230579A1/en active Application Filing
- 2019-05-24 JP JP2020522151A patent/JP7299886B2/en active Active
- 2019-05-29 TW TW108118525A patent/TW202002943A/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006008574A (en) * | 2004-06-25 | 2006-01-12 | Pola Chem Ind Inc | Non-aqueous foam cosmetic imparting warm sensation |
CN102186454A (en) * | 2008-10-15 | 2011-09-14 | 株式会社资生堂 | Skin preparation composition for external use |
JP2010229100A (en) * | 2009-03-27 | 2010-10-14 | Shiseido Co Ltd | External preparation for skin |
CN104717960A (en) * | 2012-10-17 | 2015-06-17 | 考司美德制药株式会社 | Hyaluronic acid gel and method for producing same |
JP2017128524A (en) * | 2016-01-19 | 2017-07-27 | ポーラ化成工業株式会社 | Gelatinous cosmetics |
Non-Patent Citations (2)
Title |
---|
尹卫平 等, 华东理工大学出版社 * |
株式会社资生堂,资生堂(中国)投资有限公司: ""珊珂 丝润焕白爽肤水(清爽型)"", 《进口特殊化妆品注册信息》 * |
Also Published As
Publication number | Publication date |
---|---|
JPWO2019230579A1 (en) | 2021-06-10 |
WO2019230579A1 (en) | 2019-12-05 |
TW202002943A (en) | 2020-01-16 |
JP7299886B2 (en) | 2023-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5083801B2 (en) | Water-in-oil emulsified sunscreen cosmetics | |
KR102234753B1 (en) | Oil-based thickening agent, oil-based thickening composition, and cosmetic preparation | |
KR101371808B1 (en) | Water-in-oil emulsified sunscreen cosmetic composition | |
EP3213742A1 (en) | Water-in-oil emulsion sunscreen cosmetic | |
JP5813745B2 (en) | Water-in-oil emulsified sunscreen cosmetics | |
ES2692837T3 (en) | Water-in-oil emulsion cosmetics | |
EP2965743B1 (en) | Water-in-oil emulsion cosmetic composition | |
TW201907898A (en) | W/O type emulsion | |
JP2010195694A (en) | Powder dispersion and cosmetic containing this powder dispersion | |
JP2024056833A (en) | Water-in-oil emulsion cosmetics | |
CN112165932A (en) | Temperature-sensitive cosmetic | |
JP7381457B2 (en) | warming cosmetics | |
JP2017031080A (en) | Water-in-oil type skin external preparation | |
TW202128121A (en) | Water-in-oil emulsion cosmetic | |
JP6903024B2 (en) | Topical skin agent | |
JP2004083521A (en) | Hair cosmetic composition | |
CN110996901B (en) | Water-in-oil type emulsified cosmetic | |
JP6815435B2 (en) | Water-in-oil skin external preparation | |
JP5590819B2 (en) | Two-phase separation type W / O emulsifier type cosmetic | |
JP2020164524A (en) | Water-in-oil emulsified cosmetics | |
CN116782875A (en) | Water-in-oil composition | |
BR112012006666B1 (en) | COSMETIC FOR SKIN IN WATER TYPE EMULSION IN OIL |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210101 |