CN112121096A - Traditional Chinese medicine composition capable of assisting in treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine composition capable of assisting in treating hypertension and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition capable of assisting in treating hypertension and a preparation method thereof. The composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 50-80 parts of Meizhou pomelo powder, 19-50 parts of erythritol and 0-20 parts of hesperidin; the preparation method comprises the following steps: s1, collecting immature young fruits of the Meizhou pomelos, cleaning and drying; s2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder; s3, crushing erythritol, screening by a 100-mesh vibrating screen, and keeping undersize powder; s4, crushing hesperidin, screening by using a 100-mesh vibrating screen, and then retaining undersize powder; s5, fully mixing the Citrus paradisi powder, the erythritol powder and the hesperidin powder in a mixer according to the formula ratio; and S6, packaging the mixed powder. The invention solves the problems that the traditional Chinese medicine in the current market is difficult to effectively treat the hypertension and has slow effect, and the preparation method is simple and easy to implement.
Description
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition capable of assisting in treating hypertension and a preparation method thereof.
Background
Hypertension (hypertension) is a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic pressure and/or diastolic pressure) (systolic pressure not less than 140 mm hg, diastolic pressure not less than 90 mm hg), which may be accompanied by functional or organic damage to organs such as heart, brain, kidney, etc. Hypertension is the most common chronic disease and also the most major risk factor for cardiovascular and cerebrovascular diseases.
Hypertension is classified into primary and secondary. The primary hypertension has unclear etiology at present, and can be caused by heredity, obesity, long-term mental stress and other factors. Secondary hypertension can be caused by renal parenchymal disease, renal vascular disease, pheochromocytoma, primary aldosteronism, hypercortisolemia and other diseases.
The prevalence rate of hypertension of adults in China is 27.9 percent, namely about one hypertension patient exists in every three adults, and meanwhile, the prevalence rate trend is gradually increased.
At present, no good method can cure hypertension, and the treatment method is mainly controlled by oral western medicines, so that the blood pressure is controlled in a normal range, and other complications are avoided. The disadvantage of pure oral administration of western medicine is that the western medicine has certain damage to other viscera after long-term administration, and the dosage must be gradually increased along with the improvement of the drug resistance of the organism, otherwise the administration cannot be controlled. Some traditional Chinese medicines have the efficacy of reducing blood pressure and have no toxic or side effect, so that the auxiliary taking of the traditional Chinese medicines capable of reducing blood pressure becomes the choice of many patients.
The traditional Chinese medicine for reducing blood pressure which can be orally taken at present generally comprises kudzuvine root, common selfheal fruit-spike, cassia seed and the like, wherein the main active ingredient of the traditional Chinese medicine is flavonoid or anthraquinone. However, the traditional Chinese medicines currently taken by patients have low content of effective components, so that the treatment effect is slow and limited. For example, in the pueraria root, puerarin (mainly flavone) is not less than 2.4% as stipulated in the Chinese pharmacopoeia, even if the maximum puerarin content of wild pueraria root is not more than about 12%.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition capable of assisting in treating hypertension, solves the problems that the traditional Chinese medicine in the current market is difficult to effectively treat the hypertension and takes effect slowly, and has good treatment effect; the invention also provides a preparation method of the composition, which is scientific, reasonable, simple and feasible.
The traditional Chinese medicine composition capable of assisting in treating hypertension is prepared from the following traditional Chinese medicine raw materials in parts by weight: 50-80 parts of Meizhou pomelo powder, 19-50 parts of erythritol and 0-20 parts of hesperidin.
The traditional Chinese medicine composition capable of assisting in treating hypertension is preferably prepared from the following traditional Chinese medicine raw materials in parts by weight: 80 parts of Meizhou pomelo powder, 19 parts of erythritol and 1 part of hesperidin.
The traditional Chinese medicine composition capable of assisting in treating hypertension is preferably prepared from the following traditional Chinese medicine raw materials in parts by weight: 75 parts of Meizhou pomelo powder, 22 parts of erythritol and 3 parts of hesperidin.
The traditional Chinese medicine composition capable of assisting in treating hypertension is preferably prepared from the following traditional Chinese medicine raw materials in parts by weight: 70 parts of Meizhou pomelo powder, 25 parts of erythritol and 5 parts of hesperidin.
The traditional Chinese medicine composition capable of assisting in treating hypertension is preferably prepared from the following traditional Chinese medicine raw materials in parts by weight: 60 parts of Meizhou pomelo powder, 30 parts of erythritol and 10 parts of hesperidin.
Selecting immature pomelo, and the diameter of the immature fruit is 0.5-2 cm.
The erythritol content is more than 99%.
The content of hesperidin is above 96%.
The pharmacological analysis is as follows:
the Citrus paradisi Hance is rich in effective flavonoid components such as naringin, hesperidin and neohesperidin, and contains flavonoids 3% in mature Citrus paradisi Hance fruit and higher immature fructus Citri Grandis fruit content (more than 25% of dry fruit weight). Therefore, the immature young fruits of the pomelos are selected and directly crushed, and the flavonoid active ingredients are far greater than those of other traditional Chinese medicine preparations.
Erythritol is prepared by fermenting glucose, is white crystalline powder, has refreshing sweet taste, is not easy to absorb moisture, and is stable at high temperature. Can effectively correct the natural bitter taste of the traditional Chinese medicine, has the characteristic of no moisture absorption, can keep the dryness of the traditional Chinese medicine, and ensures the state and good free-running property of the traditional Chinese medicine. Meanwhile, the sugar substitute does not generate any heat, is an ideal sugar substitute and is suitable for people with high blood pressure, high blood sugar and high blood sugar.
The hesperidin, namely the neomethyl hesperidin dihydrochalcone, is characterized by no heat, high sweetness (reaching 1500 times of cane sugar), outstanding fragrance enhancing and taste enhancing effects and is suitable for patients who prefer high sweetness to eat. Meanwhile, the neohesperidin is converted from neohesperidin and belongs to flavonoid derivatives, so that the neohesperidin can be added to play a role in enhancing the treatment effect.
The preparation method of the traditional Chinese medicine composition capable of assisting in treating hypertension comprises the following steps:
s1, collecting immature young fruits of the Meizhou pomelos, cleaning and drying;
s2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder;
s3, crushing erythritol, screening by a 100-mesh vibrating screen, and keeping undersize powder;
s4, crushing hesperidin, screening by using a 100-mesh vibrating screen, and then retaining undersize powder;
s5, fully mixing the Citrus paradisi powder, the erythritol powder and the hesperidin powder in a mixer according to the formula ratio;
s6, packaging the mixed powder to obtain the Chinese medicinal composition.
The usage and dosage are as follows: dissolving 1 g of the Chinese medicinal composition in 300 ml of 80-100 deg.C hot water each time, and taking orally when the temperature is lowered to drinkable temperature. The preparation is administered once daily, and every 7 days for a treatment course.
Compared with the prior art, the invention has the following beneficial effects:
1. the traditional Chinese medicine composition solves the problems that the traditional Chinese medicine in the current market is difficult to effectively treat hypertension and takes effect slowly.
2. According to the invention, erythritol and hesperidin are added into the traditional Chinese medicine composition, so that the taste of the traditional Chinese medicine composition can be improved and the efficacy can be increased.
Detailed Description
The present invention will be further described with reference to the following embodiments.
Example 1
The traditional Chinese medicine composition is prepared by the following steps:
s1, collecting immature young fruits of the pomelos in Meizhou, cleaning and drying.
S2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder.
S3, crushing the erythritol, screening the crushed erythritol by a 100-mesh vibrating screen, and keeping undersize powder.
S4, grinding the hesperidin, screening by a 100-mesh vibrating screen, and reserving undersize powder.
S5, fully mixing 80 parts of Meizhou pomelo powder, 19 parts of erythritol powder and 1 part of hesperidin powder for 2 hours in a mixer according to the proportion.
S6, packaging the mixed powder to obtain the Chinese medicinal composition.
Example 2
The traditional Chinese medicine composition is prepared by the following steps:
s1, collecting immature young fruits of the pomelos in Meizhou, cleaning and drying.
S2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder.
S3, crushing the erythritol, screening the crushed erythritol by a 100-mesh vibrating screen, and keeping undersize powder.
S4, grinding the hesperidin, screening by a 100-mesh vibrating screen, and reserving undersize powder.
S5, mixing 75 parts of Meizhou pomelo powder, 22 parts of erythritol powder and 3 parts of hesperidin powder fully in a mixer for 2 hours according to the proportion.
S6, packaging the mixed powder to obtain the Chinese medicinal composition.
Example 3
The traditional Chinese medicine composition is prepared by the following steps:
s1, collecting immature young fruits of the pomelos in Meizhou, cleaning and drying.
S2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder.
S3, crushing the erythritol, screening the crushed erythritol by a 100-mesh vibrating screen, and keeping undersize powder.
S4, grinding the hesperidin, screening by a 100-mesh vibrating screen, and reserving undersize powder.
S5, fully mixing 70 parts of Meizhou pomelo powder, 25 parts of erythritol powder and 5 parts of hesperidin powder for 2 hours in a mixer according to the proportion.
S6, packaging the mixed powder to obtain the Chinese medicinal composition.
Example 4
The traditional Chinese medicine composition is prepared by the following steps:
s1, collecting immature young fruits of the pomelos in Meizhou, cleaning and drying.
S2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder.
S3, crushing the erythritol, screening the crushed erythritol by a 100-mesh vibrating screen, and keeping undersize powder.
S4, grinding the hesperidin, screening by a 100-mesh vibrating screen, and reserving undersize powder.
S5, mixing 60 parts of Meizhou pomelo powder, 30 parts of erythritol powder and 10 parts of hesperidin powder fully in a mixer for 2 hours according to the proportion.
S6, packaging the mixed powder to obtain the Chinese medicinal composition.
Curative effect judgment and result: through the treatment observation of 100 patients taking the traditional Chinese medicine composition for a long time in one year, the traditional Chinese medicine composition has obvious auxiliary treatment effect on the patients who normally take antihypertensive drugs.
Has certain antihypertensive effect on hypertension patients who have not taken other medicines.
No relevant side effects appear.
Typical cases are:
case 1
Liu Yi, male, 52 years old, suffered from hypertension and long-term administration of western medicines, the blood pressure is unstable, after auxiliary administration of the Chinese medicinal composition for 5 courses, the blood pressure is kept stable, the blood pressure value is always stable at about 140/89, and the phenomenon of severe fluctuation is avoided.
Case 2
Old women, age 42, have slight hypertension, which has not been treated by taking medicine before, after taking the Chinese medicinal composition for 4 courses, the blood pressure keeps normal value all the time, and no other obvious side effects are felt.
Case 3
Zhangzhi, male, 37 years old, has slight hypertension, has not been treated by taking medicine before, after taking this Chinese medicinal composition for 3 courses, the blood pressure value keeps the normal value, has no obvious fluctuation, does not feel other obvious side effects.
The embodiments described above are some, but not all embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for adjuvant therapy of hypertension is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 50-80 parts of Meizhou pomelo powder, 19-50 parts of erythritol and 0-20 parts of hesperidin.
2. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 80 parts of Meizhou pomelo powder, 19 parts of erythritol and 1 part of hesperidin.
3. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 75 parts of Meizhou pomelo powder, 22 parts of erythritol and 3 parts of hesperidin.
4. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 70 parts of Meizhou pomelo powder, 25 parts of erythritol and 5 parts of hesperidin.
5. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60 parts of Meizhou pomelo powder, 30 parts of erythritol and 10 parts of hesperidin.
6. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: selecting immature pomelo, and the diameter of the immature fruit is 0.5-2 cm.
7. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the erythritol content is more than 99%.
8. The traditional Chinese medicine composition for adjuvant therapy of hypertension according to claim 1, which is characterized in that: the content of hesperidin is above 96%.
9. A method for preparing the traditional Chinese medicine composition for adjuvant therapy of hypertension according to any one of claims 1 to 8, which is characterized in that: the method comprises the following steps:
s1, collecting immature young fruits of the Meizhou pomelos, cleaning and drying;
s2, crushing the dried young fruits, and screening by a 100-mesh vibrating screen to keep undersize powder;
s3, crushing erythritol, screening by a 100-mesh vibrating screen, and keeping undersize powder;
s4, crushing hesperidin, screening by using a 100-mesh vibrating screen, and then retaining undersize powder;
s5, fully mixing the Citrus paradisi powder, the erythritol powder and the hesperidin powder in a mixer according to the formula ratio;
s6, packaging the mixed powder to obtain the Chinese medicinal composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011146433.XA CN112121096A (en) | 2020-10-23 | 2020-10-23 | Traditional Chinese medicine composition capable of assisting in treating hypertension and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10262599A (en) * | 1997-03-27 | 1998-10-06 | Nikken Chem Co Ltd | Production of erythritol improved in taste |
| CN110810522A (en) * | 2019-12-31 | 2020-02-21 | 中国计量大学 | Sea-buckthorn, agaric and pearl milk tea and preparation method thereof |
-
2020
- 2020-10-23 CN CN202011146433.XA patent/CN112121096A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10262599A (en) * | 1997-03-27 | 1998-10-06 | Nikken Chem Co Ltd | Production of erythritol improved in taste |
| CN110810522A (en) * | 2019-12-31 | 2020-02-21 | 中国计量大学 | Sea-buckthorn, agaric and pearl milk tea and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 梅州: "梅州金柚", 《梅州市梅江区人民政府（HTTP://WWW.MEIJIANG.GOV.CN/MSFW/LYFW/MJTC/CONTENT/POST_408735.HTML）》 * |
| 陈良等: "新甲基橙皮苷二氢查耳酮的应用研究进展", 《饮料工业》 * |
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Application publication date: 20201225 |
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