CN112119923A - Mouse cage for murine syrup preference experiment - Google Patents
Mouse cage for murine syrup preference experiment Download PDFInfo
- Publication number
- CN112119923A CN112119923A CN202011120686.XA CN202011120686A CN112119923A CN 112119923 A CN112119923 A CN 112119923A CN 202011120686 A CN202011120686 A CN 202011120686A CN 112119923 A CN112119923 A CN 112119923A
- Authority
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- China
- Prior art keywords
- cage
- automatic ball
- turntable
- bearing
- drinking water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000002474 experimental method Methods 0.000 title claims abstract description 19
- 241001529936 Murinae Species 0.000 title claims description 7
- 239000006188 syrup Substances 0.000 title description 8
- 235000020357 syrup Nutrition 0.000 title description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000003651 drinking water Substances 0.000 claims abstract description 33
- 235000020188 drinking water Nutrition 0.000 claims abstract description 33
- 241000555745 Sciuridae Species 0.000 claims abstract description 23
- 230000035622 drinking Effects 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 20
- 238000012360 testing method Methods 0.000 abstract description 13
- 241000699670 Mus sp. Species 0.000 abstract description 4
- 235000009508 confectionery Nutrition 0.000 abstract description 4
- 241000700159 Rattus Species 0.000 abstract 1
- 238000010998 test method Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 4
- 208000007415 Anhedonia Diseases 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000017194 Affective disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
- A01K1/0356—Feeding or drinking devices associated with cages
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Catching Or Destruction (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The embodiment of the application discloses a squirrel cage that is used for mouse sweet water preference experiment, the squirrel cage includes cage lid and box, includes: the turntable is rotatably arranged on the cage cover through a bearing, and the bearing is fixed on the cage cover; the bearing is connected with a driving device and a timer, and the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer; the automatic ball drinking water bottle comprises a turntable, a suction nozzle, a weight counter, a display screen and a water bottle body, wherein at least two automatic ball drinking water bottles are arranged on the turntable at intervals, liquid with different sweetness is filled in each automatic ball drinking water bottle, balls are arranged in the suction nozzle of each automatic ball drinking water bottle, the weight counter is arranged on the bottle body of each automatic ball drinking water bottle, and the display screen displays the weight of the liquid in the drinking water bottle; when the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer, at least two automatic ball drinking bottles on the turntable rotate by the preset angle. The test method can be more convenient and accurate for testing the sugar water preference experimental data of rats or mice.
Description
Technical Field
The application relates to the technical field of animal science experiments and research devices, in particular to a mouse cage for a murine syrup preference experiment.
Background
The sugar water preference test is an experiment for testing the sugar water preference degree of a rat or a mouse, is a test index for reflecting the anhedonia of the rat or the mouse, the anhedonia refers to lack of interest in stimulation of rewards such as food, sex and the like, and is used as a core index for evaluating an affective disorder disease model such as a depressed rat or a mouse model, and the sugar water preference experiment has irreplaceable significance. There is no experimental device specially used for sugar water preference test in the experiment, and a common squirrel cage is usually used for adding a water bottle on the other side for testing, so that the problems are that: at first ordinary squirrel cage opposite side does not reserve the locating hole of the bottle of draining specially, can lead to the water-jug to rock from top to bottom in the test like this and lead to the weeping, also can lead to the weeping in the experiment mouse drinks water in addition, need exchange the position of water-jug when the test in addition, place during the calculation quality and remove the water-jug in-process and also can lead to the weeping, synthesize like this and can make the evaluation that the syrup preference experimental error is very big influence the behaviouristics experiment.
Disclosure of Invention
The embodiment of the application provides a squirrel cage for a mouse sugar water preference experiment, which can be more convenient and accurate for testing the sugar water preference experiment data of a rat or a mouse.
The application provides a squirrel cage that is used for mouse sweet water preference experiment, the squirrel cage includes cage lid and box, its characterized in that, the squirrel cage includes:
the turntable is rotatably arranged on the cage cover through a bearing, and the bearing is fixed on the cage cover;
the bearing is connected with a driving device and a timer, and the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer;
the automatic ball drinking water bottle comprises a turntable, a suction nozzle, a weight counter, a display screen and a water bottle body, wherein the turntable is provided with at least two automatic ball drinking water bottles at intervals, liquid with different sweetness degrees is filled in each automatic ball drinking water bottle, a ball is arranged in the suction nozzle of each automatic ball drinking water bottle, the body of each automatic ball drinking water bottle is provided with the weight counter, the weight counter is provided with the display screen, and the display screen displays the weight of the liquid in the drinking water bottle;
and when the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer, at least two automatic ball drinking bottles on the turntable rotate by the preset angle.
In some embodiments, the automatic ball drinking water bottle rack further comprises a plurality of brackets, each bracket is fixed on the turntable through a screw, and each automatic ball drinking water bottle is correspondingly erected on the bracket.
In some embodiments, the cage is made of stainless steel wire that forms the cage into a mesh that is larger than the diameter of the mouth of the automatic ball drink bottle.
In some embodiments, the turntable is circular, and the at least two automatic ball-point drinking bottles are arranged at intervals on the periphery of the turntable.
In some embodiments, the drive device is connected to an external power source, or is equipped with a battery.
In some embodiments, when two automatic ball drinking water bottles are installed on the turntable at intervals, the predetermined angle is 180 °, and the two automatic ball drinking water bottles contain purified water and sweet water therein, respectively.
In some embodiments, the cage cover is movably arranged on the box body, the left side and the right side of the box body are provided with buckling grooves, and the left end and the right end of the cage cover and the small door are provided with buckles matched with the buckling grooves for fixing the movable cage cover on the box body.
In some embodiments, the front wall and the rear wall of the box body are higher than the height of the cage cover arranged on the box body, so that the cage cover is limited.
In some embodiments, tie rods are provided on the cage cover to increase the rigidity of the cage cover.
In some embodiments, a mat is disposed within the housing, the thickness of the mat being dependent upon the size of the laboratory mouse.
Above-mentioned squirrel cage for experiment of murine syrup preference, cover the installation at the cage and can install the automatic ball drinking water bottle of the time cycle automatic rotation ground of setting for, measure the liquid consumption in the drinking water bottle under the condition of not moving the water-jug, convenient operation is swift, the efficiency of experiment has also been improved simultaneously, be equipped with the steel ball in the suction nozzle of water-jug in addition, control the speed of water outlet, prevent to leak, the problem of error is caused easily when having reduced conventional drinking water bottle and measuring drinking water consumption, make the test rat or mouse's the preferable experimental data of syrup more convenient, accurate.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings used in the description of the embodiments will be briefly introduced below.
FIG. 1 is a schematic diagram of a squirrel cage configuration for a murine carbohydrate water preference test in some embodiments;
fig. 2 is a schematic diagram of a structure of a turntable on a squirrel cage for a rodent sugar water preference experiment in some embodiments.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the specification of the present application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.
As used in this specification and the appended claims, the term "if" may be interpreted contextually as "when", "upon" or "in response to a determination" or "in response to a detection". Similarly, the phrase "if it is determined" or "if a [ described condition or event ] is detected" may be interpreted contextually to mean "upon determining" or "in response to determining" or "upon detecting [ described condition or event ]" or "in response to detecting [ described condition or event ]".
In some embodiments of the present application, as shown in fig. 1 and 2, a squirrel cage 10 for use in a rodent sugar water preference test is provided, the squirrel cage comprising a cage cover 12 and a tank 14, the squirrel cage 10 further comprising: the bearing 16 is fixed to the cage cover 12 by means of a turntable 18 which is rotatably arranged on the cage cover 12 by means of the bearing 16. The bearing 16 is connected to a driving means (not shown) and a timer (not shown), both of which may be mounted on the top end or the periphery of the bearing, which drives the bearing to rotate a predetermined angle, for example, 30 ° every one hour, according to the timing period of the timer. At least two automatic ball drinking bottles 20 are mounted on the turntable 18 at intervals, and each automatic ball drinking bottle 20 contains liquid with different sweetness, in this embodiment, sugar water with different concentration. And balls are arranged in the suction nozzle of each automatic ball drinking water bottle 20, a weighing device 22 is arranged on the bottle body of each automatic ball drinking water bottle 20, the weighing device 22 is provided with a display screen (not shown) which displays the weight of liquid in the drinking water bottle, and the weighing device adopts a weighing device with higher metering precision and can be accurate to microgram or microliter. The display screen may be a small LED display screen and the weight scale with the display screen may be battery powered. When the driving device drives the bearing 16 to rotate by a predetermined angle according to the timing period of the timer, at least two automatic ball drinking bottles 20 on the turntable 18 rotate by a predetermined angle.
It should be noted that at least two automatic ball water bottles 20 may be two, three or more, and the number is not limited specifically, the automatic ball water bottles 20 are spaced apart, and the concentration of sugar water in each automatic ball water bottle 20 is different, and here, the automatic ball water bottles 20 may be numbered for distinguishing, and each number corresponds to a sugar water concentration, so that the experimenter can record and identify the number.
Above-mentioned squirrel cage that is used for murine syrup preference experiment, cover the installation at the cage and can install the automatic ball drinking water bottle of the time cycle automatic rotation ground of setting for, measure the liquid consumption in the drinking water bottle under the condition of unmovable water-jug, convenient operation is swift, the efficiency of experiment has also been improved simultaneously, be equipped with the steel ball in the suction nozzle of water-jug in addition, control the speed of water, prevent to leak, the problem of error is caused easily when having reduced conventional drinking water bottle and measuring drinking water consumption, it is more convenient to the syrup preference experimental data of test rat or mouse, it is accurate.
In some embodiments, the cage cover 12 is movably disposed on the box 14, the left and right sides of the box 14 are provided with fastening slots, and the left and right ends of the cage cover 12 and the small door are provided with fasteners matched with the fastening slots for fixing the movable cage cover on the box. Therefore, the mouse cage can be conveniently opened to operate big and small mice, and meanwhile, the sealing performance of the mouse cage is ensured to prevent the mice from drilling out.
Further, in some embodiments, the front and rear walls of the housing 14 are higher than the height of the cage 12 disposed on the housing 14 to limit the cage 12 so that the cage is not easily detached.
In some embodiments, a mat is provided within the housing 14, the thickness of which depends on the size of the laboratory mouse. To the mouse that the size is little, the thickness of the bedding and padding of covering is great relatively, and to the mouse that the size is big, the thickness of the bedding and padding of covering is less relatively, is equipped with the bedding and padding purpose in the box and makes things convenient for the mouse can reach the suction nozzle of water-jug and drink water.
In some embodiments, cross-braces are provided on the cage cover 12 to increase the rigidity of the cage cover 12, which makes the cage more robust.
In some embodiments, the drive device is connected to an external power source, or is equipped with a battery. After the driving device is electrified, when the timing moment is reached, the rotating turntable 18 of the driving bearing 16 is rotated to drive the automatic ball drinking bottle to rotate, so that the position of the automatic ball drinking bottle is changed, the mouse is prevented from memorizing the drunk water bottle, and the mouse sweet water preference is conveniently tested.
In some embodiments, the predetermined angle is 180 ° when two automatic ball drinking bottles are mounted on the turntable 18 at intervals, the two automatic ball drinking bottles containing purified water and sweetened water, respectively.
In some embodiments, the at least two automatic ball-drink bottles are secured to the turntable by screws.
In some embodiments, the cage cover is made of stainless steel wires that make the cage cover a grid shape, the grid shape is larger than the diameter of the suction nozzle of the automatic ball drinking bottle 20, so that the suction nozzle of the automatic ball drinking bottle 20 can be conveniently inserted into the box body 14, and mice can drink water conveniently.
In some embodiments, the turntable 18 is circular and at least two automatic ball drink bottles 20 are spaced about the periphery of the turntable 18.
When the rotary table 18 is circular, the rotating shaft 16 can be arranged at the position of the circle center, the rotating shaft 16 is connected with the circular rotary table 18 to form a hub shape, the rotating shaft 16 enables the circular rotary table to rotate under the electric drive of the driving device, and the rotary table 18 is circular to enable the stability of the rotary table to be better.
The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the present application, and these modifications or substitutions should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (10)
1. A squirrel cage for murine sugar water preference experiments, the squirrel cage comprising a cage cover and a cage body, characterized in that the squirrel cage comprises:
the turntable is rotatably arranged on the cage cover through a bearing, and the bearing is fixed on the cage cover;
the bearing is connected with a driving device and a timer, and the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer;
the automatic ball drinking water bottle comprises a turntable, a suction nozzle, a weight counter, a display screen and a water bottle body, wherein the turntable is provided with at least two automatic ball drinking water bottles at intervals, liquid with different sweetness degrees is filled in each automatic ball drinking water bottle, a ball is arranged in the suction nozzle of each automatic ball drinking water bottle, the body of each automatic ball drinking water bottle is provided with the weight counter, the weight counter is provided with the display screen, and the display screen displays the weight of the liquid in the drinking water bottle;
and when the driving device drives the bearing to rotate by a preset angle according to the timing period of the timer, at least two automatic ball drinking bottles on the turntable rotate by the preset angle.
2. The squirrel cage of claim 1, further comprising a number of brackets equal to the number of automatic ball watering bottles, each bracket being secured to the turntable by screws, each automatic ball watering bottle being correspondingly mounted on the bracket.
3. The squirrel cage of claim 1 wherein the cage cover is made of stainless steel wires that form the cage cover into a grid that is larger than the diameter of the mouth of the automatic ball drinking bottle.
4. The squirrel cage of claim 1, wherein the turntable is circular and the at least two automatic ball drinking bottles are spaced around the periphery of the turntable.
5. The cage of claim 1 wherein the drive means is connected to an external power source or is battery mounted.
6. The squirrel cage of claim 1, wherein the predetermined angle is 180 ° when two automatic ball drinking bottles are mounted on the turntable at intervals, the two automatic ball drinking bottles containing purified water and sweetened water, respectively.
7. The squirrel cage of claim 1, wherein the cage cover is movably arranged on the box body, the left side and the right side of the box body are provided with buckling grooves, and the left end and the right end of the cage cover and the small door are provided with buckles matched with the buckling grooves for fixing the movable cage cover on the box body.
8. The cage of claim 7 wherein the front and rear walls of the housing are higher than the cage cover disposed on the housing to limit the height of the cage cover.
9. The cage of claim 1 wherein tie rods are provided on the cage cover to increase the rigidity of the cage cover.
10. The cage of claim 1 wherein a mat is provided within the cage, the thickness of the mat being dependent upon the size of the laboratory mouse.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011120686.XA CN112119923B (en) | 2020-10-19 | 2020-10-19 | Mouse cage for murine syrup preference experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011120686.XA CN112119923B (en) | 2020-10-19 | 2020-10-19 | Mouse cage for murine syrup preference experiment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112119923A true CN112119923A (en) | 2020-12-25 |
| CN112119923B CN112119923B (en) | 2021-12-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011120686.XA Expired - Fee Related CN112119923B (en) | 2020-10-19 | 2020-10-19 | Mouse cage for murine syrup preference experiment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112119923B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114376574A (en) * | 2022-01-14 | 2022-04-22 | 湖南中医药大学 | Animal depression behavior detection method and detection device based on sweet water preference |
| CN114467796A (en) * | 2021-12-14 | 2022-05-13 | 深圳先进技术研究院 | Automatic behavior testing device |
| CN114515148A (en) * | 2022-02-17 | 2022-05-20 | 成都泰盟软件有限公司 | Method for detecting depression behaviors of multiple animals preferring sweet water |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203353373U (en) * | 2013-07-26 | 2013-12-25 | 中国人民解放军军事医学科学院基础医学研究所 | Rat cage device for rat sucrose preference test |
| WO2017066228A2 (en) * | 2015-10-12 | 2017-04-20 | Virginia Commonwealth University | A mouse model of nonalcoholic steatohepatitis and uses thereof |
| CN208144143U (en) * | 2018-04-17 | 2018-11-27 | 广州医科大学 | Device for the experiment of rat syrup preference |
| CN109258491A (en) * | 2018-10-17 | 2019-01-25 | 山西医科大学 | A kind of mouse cage tested for rat or mouse syrup preference |
-
2020
- 2020-10-19 CN CN202011120686.XA patent/CN112119923B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203353373U (en) * | 2013-07-26 | 2013-12-25 | 中国人民解放军军事医学科学院基础医学研究所 | Rat cage device for rat sucrose preference test |
| WO2017066228A2 (en) * | 2015-10-12 | 2017-04-20 | Virginia Commonwealth University | A mouse model of nonalcoholic steatohepatitis and uses thereof |
| CN208144143U (en) * | 2018-04-17 | 2018-11-27 | 广州医科大学 | Device for the experiment of rat syrup preference |
| CN109258491A (en) * | 2018-10-17 | 2019-01-25 | 山西医科大学 | A kind of mouse cage tested for rat or mouse syrup preference |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114467796A (en) * | 2021-12-14 | 2022-05-13 | 深圳先进技术研究院 | Automatic behavior testing device |
| CN114376574A (en) * | 2022-01-14 | 2022-04-22 | 湖南中医药大学 | Animal depression behavior detection method and detection device based on sweet water preference |
| CN114376574B (en) * | 2022-01-14 | 2023-09-08 | 湖南中医药大学 | Animal depression behavior detection method and detection device based on sugar water preference |
| CN114515148A (en) * | 2022-02-17 | 2022-05-20 | 成都泰盟软件有限公司 | Method for detecting depression behaviors of multiple animals preferring sweet water |
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| Publication number | Publication date |
|---|---|
| CN112119923B (en) | 2021-12-14 |
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Granted publication date: 20211214 |