CN112076339A - Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof - Google Patents

Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof Download PDF

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Publication number
CN112076339A
CN112076339A CN202010970157.2A CN202010970157A CN112076339A CN 112076339 A CN112076339 A CN 112076339A CN 202010970157 A CN202010970157 A CN 202010970157A CN 112076339 A CN112076339 A CN 112076339A
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zinc oxide
antibacterial
layer
oxide nanoparticles
woven fabric
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CN112076339B (en
Inventor
张海军
鞠豪
尹玉霞
侯文博
刘爱华
张明广
卢天恒
曹明昆
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Shandong Branden Medical Devices Co Ltd
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Shandong Branden Medical Devices Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
    • D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/44—Oxides or hydroxides of elements of Groups 2 or 12 of the Periodic Table; Zincates; Cadmates
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/325—Amines
    • D06M13/342—Amino-carboxylic acids; Betaines; Aminosulfonic acids; Sulfo-betaines
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/03—Polysaccharides or derivatives thereof
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract

The invention discloses an antibacterial woundplast containing zinc oxide nanoparticles and a preparation method thereof, belonging to the technical field of medical supplies. The band-aid prepared by the invention consists of an adhesive backing, a medicine layer, a chitosan non-woven fabric layer and a peelable layer. The chitosan non-woven fabric layer contains nanometer zinc oxide connected by dipping method, and the medicine layer is attached with medicine containing traditional Chinese medicine components, which contains herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acid and compound vitamin. The invention solves the problem that the existing band-aid can not promote wound healing, and realizes the technical effects of promoting wound healing and preventing wound infection. The band-aid prepared by the invention has the advantages of simple manufacturing technology, good biocompatibility, low cost, no irritation to wounds, capability of absorbing exudates of the wounds, safety, no toxic or side effect and capability of being applied to nursing of superficial wound wounds such as small wounds, bruises, cutting wounds and the like.

Description

Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof
Technical Field
The invention belongs to the technical field of medical supplies, and particularly relates to an antibacterial woundplast containing zinc oxide nanoparticles and a preparation method thereof.
Background
Wounds are lesions of normal skin that occur under the combined action of external wound-causing factors (external force, heat, surgery, current, chemicals, cold, etc.) and intrinsic factors of the body (local insufficiency of blood supply). The appearance of wounds is generally accompanied by a loss of skin integrity and loss of part of normal tissue, resulting in impaired normal function of the skin. Wound repair is a complex process in which multiple cells and multiple cytokines participate together, and the wound dressing plays an important role in the process of treating and repairing wounds. When the dressing is used for treating the wound, the dressing can isolate external microorganisms, avoid further infection of the wound and then promote the wound to heal by utilizing the healing and repairing capacity of the dressing. After the theory of moist healing is put forward, people tend to use novel dressings such as liquid dressings or hydrogel dressings which accord with the theory of moist healing more and more, but most of the novel dressings are still in the test stage at present, and the commercialized products are few. The band-aid is popular among different people due to the rapid hemostasis and band-aid functions, and is still a necessary medical instrument for people to go out, stay at home and work in a future period of time.
The band-aid mainly comprises a plane adhesive tape, a water absorption layer and a strippable layer, and has the functions of stopping bleeding and protecting wound. Its hemostatic action is mainly based on the pressure formed by the adhesion of plane adhesive plaster to stop bleeding and the water absorption action of water absorption layer to absorb the exudation to keep the wound relatively dry and promote the wound healing. The traditional band-aid has poor air permeability, and easily causes the propagation of anaerobic bacteria such as staphylococcus and tetanus bacillus in the using process, thereby causing the difficult healing, suppuration and scabbing of the wound surface, and influencing the regeneration of cells and the healing of the wound surface.
Disclosure of Invention
The invention aims to provide an antibacterial woundplast containing zinc oxide nanoparticles and a preparation method thereof. The band-aid prepared by the method can be used for wounds with shallow skin wounds, small wounds, little bleeding and no need of suturing, and is used for stopping bleeding, relieving pain and removing blood stasis.
The invention provides a preparation method of an antibacterial woundplast containing zinc oxide nanoparticles, which is characterized by comprising the following preparation steps:
(1) accurately weighing the required herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acid and vitamin complex in a weighing laboratory by an analytical balance to two positions after decimal point;
(2) accurately measuring and preparing the required ultrapure water by a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, a growth factor, amino acid and vitamin complex into the beaker under stirring at the speed of 50-150 r/min, stirring for dissolving, and uniformly mixing the solution;
(4) putting the non-woven fabric with the medicine layer into a medicine soaking groove, soaking for 1-10 min, then putting into a drying oven at 40-50 ℃ for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-grade zinc oxide for 10-30 min at 25-35 ℃. Then drying at 40-80 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilization by irradiation or ethylene oxide sterilization; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
The adhesive backing used in the invention adopts one of medical PU film, medical elastic cloth or medical non-woven fabric, and is coated with low-allergy medical pressure-sensitive adhesive; the medicine layer contains herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acids and compound vitamins, and is prepared by soaking non-woven fabric in medicinal liquid; the liquid medicine consists of the following components in percentage by mass: 4-10% of herba cepbalanoplosis segeti extract, 0-5% of chitosan quaternary ammonium salt, 0.01-0.05% of growth factor, 0-2% of amino acid, 0-2% of vitamin complex and 80.95-95.99% of ultrapure water; the herba Cephalanoploris extract is prepared by the extraction method described in patent application No. 202010890248.5; the chitosan quaternary ammonium salt is a white or off-white powdery solid prepared by chemically modifying chitosan, and the molecular weight is between 1000 and 100 ten thousand; the growth factor is one or more of Epidermal Growth Factor (EGF), Keratinocyte Growth Factor (KGF), Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), transforming growth factor (TGF alpha and TGF beta); the amino acid is one or more of glycine, alanine, valine, leucine, isoleucine, phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine and histidine; the vitamin complex is vitamin complex composed of vitamin K and one or more of vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin C, vitamin E and inositol; the ultrapure water is water which meets the requirements of injection water items in Chinese pharmacopoeia 2015 edition, namely distilled water or water obtained by secondary distillation of deionized water; the chitosan non-woven fabric is medical grade pure chitosan fiber spunlace non-woven fabric which is connected with nano-scale zinc oxide by an immersion method; the peelable layer is glassine paper, CCK paper or PET film.
The chitosan non-woven fabric is used as a contact layer with the wound, so that the air permeability is good, the wound and the skin around the wound cannot be whitened and softened after long-term use, the nano-zinc oxide contained in the chitosan non-woven fabric layer has good antibacterial property, the secondary bacterial infection of the wound is prevented, the chitosan non-woven fabric is a biological material, the allergy phenomenon can be greatly reduced, and the wound healing can be accelerated by the traditional Chinese medicine components in the medicine layer.
Drawings
FIG. 1 is a flow chart of the production of the adhesive bandage; fig. 2 is a structure view of the adhesive bandage product.
Detailed Description
The invention discloses an antibacterial woundplast containing zinc oxide nanoparticles, which is prepared by the following steps:
(1) accurately weighing the required herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acid and vitamin complex in a weighing laboratory by an analytical balance to two positions after decimal point;
(2) accurately measuring and preparing the required ultrapure water by a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, a growth factor, amino acid and vitamin complex into the beaker under stirring at the speed of 50-150 r/min, stirring for dissolving, and uniformly mixing the solution;
(4) putting the non-woven fabric with the medicine layer into a medicine soaking groove, soaking for 1-10 min, then putting into a drying oven at 40-50 ℃ for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-grade zinc oxide for 10-30 min at 25-35 ℃. Then drying at 40-80 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilization by irradiation or ethylene oxide sterilization; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
Example 1
(1) Accurately weighing 5.00g of herba Cephalanoploris extract, 2.00g of chitosan quaternary ammonium salt, 0.02g of growth factor, 1.00g of amino acid and 1.00g of compound vitamin by an analytical balance in a weighing laboratory, and accurately measuring two bits after decimal point;
(2) 90.98ml of ultrapure water is accurately measured through a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins into the beaker under stirring at the speed of 120r/min, stirring for dissolving, and uniformly mixing the solution;
(4) placing the non-woven fabric with the medicine layer into a medicine soaking tank, soaking for 10min, then placing into a 45-DEG C oven for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-scale zinc oxide at 30 ℃ for 10 min. Then drying at 40 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilizing by irradiation; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
Example 2
(1) Accurately weighing 6.00g of herba Cephalanoploris extract, 3.00g of chitosan quaternary ammonium salt, 0.02g of growth factor, 1.00g of amino acid and 1.00g of compound vitamin by an analytical balance in a weighing laboratory, and accurately measuring two bits after decimal point;
(2) 88.98ml of ultrapure water is accurately measured through a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins into the beaker under stirring at the speed of 120r/min, stirring for dissolving, and uniformly mixing the solution;
(4) placing the non-woven fabric with the medicine layer into a medicine soaking tank, soaking for 10min, then placing into a 45-DEG C oven for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-scale zinc oxide at 30 ℃ for 10 min. Then drying at 40 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilizing by irradiation; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
Example 3
(1) Accurately weighing 6.00g of herba Cephalanoploris extract, 3.00g of chitosan quaternary ammonium salt, 0.02g of growth factor, 1.50g of amino acid and 1.50g of compound vitamin by an analytical balance in a weighing laboratory, and accurately measuring two bits after decimal point;
(2) 87.98ml of ultrapure water is accurately measured through a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins into the beaker under stirring at the speed of 120r/min, stirring for dissolving, and uniformly mixing the solution;
(4) placing the non-woven fabric with the medicine layer into a medicine soaking tank, soaking for 10min, then placing into a 45-DEG C oven for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-scale zinc oxide at 30 ℃ for 10 min. Then drying at 40 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilizing by ethylene oxide; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
Example 4
(1) Accurately weighing 8.00g of herba Cephalanoploris extract, 5.00g of chitosan quaternary ammonium salt, 0.05g of growth factor, 2.00g of amino acid and 2.00g of compound vitamin by an analytical balance in a weighing laboratory, and accurately measuring two bits after decimal point;
(2) 82.95ml of ultrapure water is accurately measured through a measuring cylinder and a pipette;
(3) adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins into the beaker under stirring at the speed of 120r/min, stirring for dissolving, and uniformly mixing the solution;
(4) placing the non-woven fabric with the medicine layer into a medicine soaking tank, soaking for 10min, then placing into a 45-DEG C oven for drying, and repeating the steps twice;
(5) soaking the chitosan non-woven fabric in finishing liquid containing nano-scale zinc oxide at 30 ℃ for 10 min. Then drying at 40 ℃, and repeating the steps twice;
(6) cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently;
(7) sterilizing by ethylene oxide; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
Detection of properties of adhesive bandage
Cytotoxicity experiments (detection method according to GB/T142332-2005 chapter eight), irritation and sensitization experiments (detection method according to GB/T16886.10-2017), intradermal reactions (detection method according to GB/T16886.10-2017), systemic acute toxicity experiments (detection method according to GB/T16886.11-2011) and heavy metal content detection (detection method according to Chinese pharmacopoeia 2015 edition 0821 heavy metal inspection method) are respectively carried out on the band-aid prepared in examples 1 to 4. The results of detecting the residual amount of epichlorohydrin in examples 3 and 4 according to the method reported by yaojian et al (yaojian, gc-mass spectrometry for determining the residual amount of epichlorohydrin in ethylene glycol diglycidyl ether, physicochemical examination-chemical division, 2018, vol 54) are shown in table 1.
TABLE 1 biological property detection experiment result of antibacterial band-aid containing zinc oxide nanoparticles
Figure 345593DEST_PATH_IMAGE002
The relevant experimental results of the embodiments 1 to 4 of the invention also show that the antibacterial band-aid has no cytotoxicity, good biocompatibility, no irritation and allergy, no harm to human body and accords with the detection standard of medical and sanitary products. The sterilization effect of the adhesive bandage is mainly related to the nano zinc oxide, chitosan and chitosan quaternary ammonium salt contained in the adhesive bandage, and the growth factor and the traditional Chinese medicine extract contained in the adhesive bandage promote the healing of wounds.
Wound plaster healing experiment
Healthy 5-6 week old C57BL/6 male mice should be used for healing experiments, and the mice should be acclimatized and maintained according to ISO 10993-2. The healing experiments were performed on the adhesive bandages of examples 1 to 4, and the specific experimental steps were as follows: the experiment was performed 3 to 5 days after adaptive feeding of 25C 57BL/6 male mice randomly divided into five groups, numbers A, B, C, D and E. Respectively placing mice into tail vein injection fixator, cutting wounds with similar depth and size at the tail part of the mice, respectively using the band-aid in the embodiments 1 to 4 for the groups A to D, naturally healing the group E without any treatment as a control group, normally breeding the groups A to D, replacing a new band-aid every 24h, observing and recording the healing condition of the wounds, respectively healing the wounds of the mice treated by the band-aid after 24h, and healing the blank control mice after 72 h; after 96 hours, the wound of the mouse treated by the band-aid is basically completely healed, no infection phenomenon occurs in the healing process, and the untreated wound can be healed after 168 hours, which shows that the band-aid can effectively promote the wound healing and prevent the wound infection, and the band-aid can be derived from the antibacterial activity of the nano-zinc oxide and the anti-inflammatory and hemostatic activities of the herba cepbalanoplosis segeti extract.
The above embodiments are only used for illustrating the technical solutions of the present invention, and do not limit the technical scope of the present invention at all, and it is still possible for a person skilled in the art to make minor modifications to the technical solutions described in the foregoing embodiments, or to make equivalent substitutions for some technical features, and these modifications or substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions claimed in the present invention.

Claims (13)

1. An antibacterial woundplast containing zinc oxide nanoparticles is characterized by consisting of an adhesive backing, a drug layer, a chitosan non-woven fabric layer and a peelable layer.
2. The antibacterial woundplast containing zinc oxide nanoparticles as claimed in claim 1, wherein the adhesive backing is coated with hypoallergenic medical pressure sensitive adhesive by using one of medical PU film, medical stretch cloth and medical nonwoven fabric according to the characteristics of the prepared woundplast.
3. The antibacterial adhesive bandage containing zinc oxide nanoparticles as claimed in claim 1, wherein the drug layer comprises herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acids and vitamin complex, and is prepared by soaking non-woven fabric in liquid medicine.
4. The antibacterial woundplast containing zinc oxide nanoparticles according to claim 1, wherein the liquid medicine comprises the following components by mass percent: 4-10% of herba cepbalanoplosis segeti extract, 0-5% of chitosan quaternary ammonium salt, 0.01-0.05% of growth factor, 0-2% of amino acid, 0-2% of vitamin complex and 80.95% -95.99% of ultrapure water.
5. The antibacterial adhesive bandage containing zinc oxide nanoparticles of claim 1, wherein the herba Cirsii extract is prepared by the extraction method of patent application No. 202010890248.5.
6. The antibacterial woundplast containing zinc oxide nanoparticles as claimed in claim 1, wherein the chitosan quaternary ammonium salt is white or off-white powdery solid prepared by chemical modification of chitosan, and the molecular weight is 1000-100 ten thousand.
7. The antibacterial woundplast containing zinc oxide nanoparticles as claimed in claim 1, wherein the growth factor used is one or more of Epidermal Growth Factor (EGF), Keratinocyte Growth Factor (KGF), Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), transforming growth factor (TGF α and TGF β).
8. The zinc oxide nanoparticle-containing antibacterial wound patch according to claim 1, wherein the amino acid used is a combination of one or more of glycine, alanine, valine, leucine, isoleucine, phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine and histidine.
9. The antibacterial woundplast containing zinc oxide nanoparticles as claimed in claim 1, wherein the vitamin complex is vitamin complex consisting of vitamin K and one or more of vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin C, vitamin E and inositol.
10. The antibacterial adhesive bandage containing zinc oxide nanoparticles of claim 1, wherein the ultrapure water used is water which meets the requirements of the Chinese pharmacopoeia 2015 edition water for injection, namely distilled water or water obtained by secondary distillation of deionized water.
11. The antibacterial band aid containing zinc oxide nanoparticles according to claim 1, wherein the chitosan non-woven fabric is medical-grade pure chitosan fiber spunlace non-woven fabric, and the non-woven fabric is connected with nanoscale zinc oxide by an impregnation method.
12. The antibacterial woundplast containing zinc oxide nanoparticles as claimed in claim 1, wherein the peelable layer is glassine paper, CCK paper or PET film.
13. The antibacterial woundplast containing zinc oxide nanoparticles according to claim 1, characterized in that the preparation method comprises the following steps: accurately weighing the required herba Cephalanoploris extract, chitosan quaternary ammonium salt, growth factor, amino acid and vitamin complex in a weighing laboratory by an analytical balance to two positions after decimal point; accurately measuring and preparing the required ultrapure water by a measuring cylinder and a pipette; adding ultrapure water into a beaker, sequentially adding a herba cepbalanoplosis segeti extract, chitosan quaternary ammonium salt, a growth factor, amino acid and vitamin complex into the beaker under stirring at the speed of 50-150 r/min, stirring for dissolving, and uniformly mixing the solution; putting the non-woven fabric with the medicine layer into a medicine soaking groove, soaking for 1-10 min, then putting into a drying oven at 40-50 ℃ for drying, and repeating the steps twice; soaking the chitosan non-woven fabric in finishing liquid containing nano-scale zinc oxide at the temperature of 25-35 ℃ for 10-30 min, then drying at the temperature of 40-80 ℃, and repeating the steps twice; cutting the adhesive backing according to the size requirement, bonding the adhesive backing with the cut medicine layer and the chitosan non-woven fabric layer according to the size specification requirement, positioning the medicine layer and the chitosan non-woven fabric layer in the middle of the adhesive backing, attaching the strippable layer to the adhesive surface of the adhesive backing, and sealing the cold-seal color paper and the white paper from the adhesive backing with the strippable layer up and down respectively so that each band-aid is sealed independently; sterilization by irradiation or ethylene oxide sterilization; and (3) after sterilization, obtaining the corresponding antibacterial woundplast containing zinc oxide nanoparticles.
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