CN112043592A - Liquid passing device and radiopharmaceutical preparation equipment - Google Patents
Liquid passing device and radiopharmaceutical preparation equipment Download PDFInfo
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- CN112043592A CN112043592A CN202010869429.XA CN202010869429A CN112043592A CN 112043592 A CN112043592 A CN 112043592A CN 202010869429 A CN202010869429 A CN 202010869429A CN 112043592 A CN112043592 A CN 112043592A
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- 239000007788 liquid Substances 0.000 title claims abstract description 270
- 229940121896 radiopharmaceutical Drugs 0.000 title claims abstract description 51
- 239000012217 radiopharmaceutical Substances 0.000 title claims abstract description 51
- 230000002799 radiopharmaceutical effect Effects 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title description 9
- 230000007246 mechanism Effects 0.000 claims abstract description 25
- 238000007599 discharging Methods 0.000 claims abstract description 24
- 229920001971 elastomer Polymers 0.000 claims description 6
- 239000000806 elastomer Substances 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 abstract description 16
- 239000003814 drug Substances 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000003825 pressing Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 238000001125 extrusion Methods 0.000 description 6
- 229930182555 Penicillin Natural products 0.000 description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 5
- 229940049954 penicillin Drugs 0.000 description 5
- 210000001503 joint Anatomy 0.000 description 3
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2037—Separating means having valve means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The application provides a cross liquid device and radiopharmaceutical and prepare equipment relates to medical equipment technical field. The liquid passing device comprises a liquid inlet pipe, an air discharging mechanism and a liquid outlet pipe. The air discharge mechanism is provided with a first cavity, one end of the air discharge mechanism is provided with a first inlet communicated with the first cavity, the air discharge mechanism is connected to one end of the liquid inlet pipe through the first inlet, the other end of the air discharge mechanism is provided with a first outlet and a second outlet which are mutually independent and communicated with the first cavity, the first outlet is provided with an emptying pipe, the emptying pipe is communicated with the atmosphere, the emptying pipe is provided with a first valve, and the second outlet is provided with a second valve. The liquid outlet pipe is connected with the second outlet. The first valve comprises a float valve and the second valve comprises a one-way valve. The liquid passing device is used for transferring the radioactive medicine prepared by the generator into a container for containing the radioactive medicine, and splashing caused by transferring the radioactive liquid by using an injector is avoided.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a liquid passing device and a radioactive drug preparation device.
Background
In the process of preparing the radiopharmaceutical, the liquid needs to be led out and injected for multiple times, the manual operation is generally realized by pumping of an injector, splashing can often occur in the process, the pollution and the damage to the environment and preparation personnel are caused, and the medicine waste and the environmental pollution are caused by the residue in the injector.
At the same time, the liquid remaining in the generator canister before it can affect the radiopharmaceutical being prepared.
Disclosure of Invention
An object of the embodiments of the present application is to provide a liquid passing device and a radiopharmaceutical preparation apparatus, which can improve the technical problem that the existing manner of suctioning a radiopharmaceutical is easy to splash, and can discharge the liquid remaining in a generator tank before suctioning.
In a first aspect, an embodiment of the present application provides a liquid passing apparatus, which includes a liquid inlet pipe, an air discharging mechanism, and a liquid outlet pipe.
The air discharge mechanism is provided with a first cavity, one end of the air discharge mechanism is provided with a first inlet communicated with the first cavity, the air discharge mechanism is connected to one end of the liquid inlet pipe through the first inlet, the other end of the air discharge mechanism is provided with a first outlet and a second outlet which are mutually independent and communicated with the first cavity, the first outlet is provided with an emptying pipe, the emptying pipe is communicated with the atmosphere, the emptying pipe is provided with a first valve, and the second outlet is provided with a second valve.
The liquid outlet pipe is connected with the second outlet.
The first valve comprises a float valve and the second valve comprises a one-way valve.
In above-mentioned realization process, the liquid device of crossing of this application can be arranged in transferring the radiopharmaceutical that makes after the generator to xiLin bottle or other containers that are used for holding the radiopharmaceutical, avoids adopting the syringe to transfer the radioactive liquid and takes place the splash. During the use, the feed liquor pipe that will cross the liquid device is connected in the liquid outlet of generator, and the drain pipe that will cross the liquid device is connected in xiLin bottle or other containers that are used for holding radiopharmaceutical to the realization will be transferred to xiLin bottle or other containers that are used for holding radiopharmaceutical through the radiopharmaceutical that the generator made after.
Meanwhile, when the liquid passing device is used for passing liquid, in the process that the liquid enters the first cavity of the air discharging mechanism from the liquid inlet pipe and is gradually filled in the first cavity, air in the liquid passing device is discharged to the atmosphere from the emptying pipe, after the liquid flows to the first valve, the first valve is closed, the pressure of the liquid enables the second valve to be opened, and the liquid flows to the liquid outlet pipe from the second outlet.
In a possible embodiment, the liquid passing device comprises an intermediate joint, one end of the liquid inlet pipe is connected to one end of the intermediate joint, and one end of the intermediate joint is connected to the first inlet.
In a possible embodiment, one end of the liquid inlet pipe has a liquid inlet pipe joint, one end of the liquid outlet pipe has a liquid outlet pipe joint, the liquid inlet pipe is connected to one end of the intermediate joint through the liquid inlet pipe joint, and the liquid outlet pipe is connected to the second outlet through the liquid outlet pipe joint.
In a possible embodiment, the liquid passing device further comprises a first cap and a second cap, the first cap is optionally connected to the other end of the liquid inlet pipe, and the second cap is optionally connected to the other end of the liquid outlet pipe.
In the implementation process, when the liquid passing device is not used, the first cover cap and the second cover cap can isolate the flow channel in the liquid passing device from the atmosphere, so that the pollution is avoided. When in use, the first cap and the second cap are taken down.
In a second aspect, embodiments of the present application provide a radiopharmaceutical dispensing apparatus comprising: generator, liquid discharging device and the liquid passing device.
The generator is internally provided with a container for placing isotopes, the generator is provided with a first liquid inlet and a first liquid outlet which are communicated with the container, and the first liquid inlet and the first liquid outlet are respectively provided with a first hollow needle head and a second hollow needle head.
The liquid drainage device is used for draining residual liquid in the generator and is provided with a second cavity, and the bottom of the liquid drainage device is optionally connected with a second hollow needle so that the second cavity is communicated with the container.
The other end of the liquid inlet pipe is optionally connected with a second hollow needle.
In the implementation process, the vessel containing the raw materials is connected to the first hollow needle head of the first liquid inlet, the raw materials are made into the radioactive drug after passing through the container for placing the isotope in the generator, the radioactive drug can be discharged from the second hollow needle head of the first liquid outlet, and the radioactive drug is transferred to a penicillin bottle or other containers for containing the radioactive drug through the liquid passing device connected to the second hollow needle head.
Before the radioactive medicine is prepared, liquid which is not completely discharged in the previous preparation may remain in the generator, and a liquid discharging device is needed to suck out the residual liquid in the generator, so that the influence of the residual liquid in the generator tank on the prepared radioactive medicine is avoided.
In one possible embodiment, the liquid discharge device comprises a first elastic body, the first elastic body is internally provided with a second cavity, the top of the first elastic body is provided with a first liquid discharge pipe communicated with the second cavity, and the bottom of the first elastic body can be pierced by a second hollow needle so as to enable the second cavity to be communicated with the second hollow needle.
In the implementation process, the first elastic body has elasticity and deforms after being extruded. When the residual liquid is discharged, the first elastic body can be contracted through extrusion, the volume of the second cavity is reduced, the first elastic body is inserted into the second hollow needle head by keeping the extrusion force unchanged, the second hollow needle head is communicated with the second cavity, the extrusion force is removed, the elasticity of the first elastic body is recovered, and the second cavity is subjected to negative pressure, so that the residual liquid in the generator is sucked into the second cavity and is discharged by the first liquid discharge pipe.
Or the first elastic body is directly inserted into the second hollow needle, the second hollow needle is communicated with the second cavity, and the residual liquid is sucked into the second cavity from the generator through external suction force and then is discharged by the first liquid discharge pipe.
In a possible embodiment, a third valve is arranged in the first drain pipe.
In a possible embodiment, the liquid discharger comprises a first liquid inlet cylinder matched with a second hollow needle by a second elastic body, a second cavity is formed inside the second elastic body, a second liquid discharge pipe communicated with the second cavity is formed in the top of the second elastic body, the first liquid inlet cylinder is connected to the bottom of the second elastic body and communicated with the second cavity, and the liquid discharger can be sleeved outside the second hollow needle through the first liquid inlet cylinder so as to be connected to the second hollow needle.
In the implementation process, the second elastic body has elasticity and deforms after being extruded. When the residual liquid is discharged, the second elastic body can be contracted through extrusion, the volume of the second cavity is reduced, the first liquid inlet cylinder is inserted into the second hollow needle head to keep the extrusion force unchanged, the extrusion force is removed, the elasticity of the second elastic body is recovered, and the second cavity is subjected to negative pressure, so that the residual liquid in the generator is sucked into the second cavity and is discharged through the second liquid discharge pipe.
Or the first liquid inlet cylinder is directly inserted into the second hollow needle, the second hollow needle is communicated with the second cavity, and the residual liquid is sucked into the second cavity from the generator through external suction force and then is discharged through the second liquid discharge pipe.
In a possible embodiment, the liquid discharging device comprises a second liquid inlet tube matched with the second hollow needle, the second liquid inlet tube is provided with a second cavity, a third liquid discharging tube communicated with the second cavity is arranged at the bottom of the second liquid inlet tube, a fourth valve is arranged in the third liquid discharging tube, a fifth valve and a second liquid outlet located on the upper side of the fifth valve are arranged at the top of the second liquid inlet tube, and the second liquid outlet is connected to the other end of the liquid inlet tube.
In the implementation process, the second liquid inlet cylinder is sleeved outside the second hollow needle, the fifth valve is closed firstly, and the residual liquid is sucked into the second cavity from the generator through external suction force and then discharged through the third liquid discharge pipe. After residual liquid in the generator is discharged, the fifth valve is opened, a vessel containing raw materials is connected to the first hollow needle head of the first liquid inlet, the raw materials are made into radioactive medicines through the container with isotopes in the generator, and the radioactive medicines enter the liquid inlet pipe of the liquid passing device through the second liquid outlet, so that the radioactive medicines made through the generator are transferred to a penicillin bottle or other containers for containing the radioactive medicines.
In one possible embodiment, the radiopharmaceutical dispensing apparatus further comprises a pump, the pump being connected to the drain.
In the above implementation, the pump can provide an external suction force to draw residual liquid from the generator to the second cavity.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.
FIG. 1 is a schematic structural diagram of a liquid passing device according to an embodiment of the present application;
FIG. 2 is a cross-sectional view of a liquid passing apparatus according to an embodiment of the present application;
FIG. 3 is a schematic structural view of an air discharge mechanism according to an embodiment of the present application;
FIG. 4 is a schematic structural view of a radiopharmaceutical dispensing apparatus of an embodiment of the present application;
FIG. 5 is a cross-sectional view of a generator according to an embodiment of the present application;
FIG. 6 is a cross-sectional view of a first drain of an embodiment of the present application;
FIG. 7 is a cross-sectional view of a second drain of an embodiment of the present application;
fig. 8 is a sectional view of a third drain device according to an embodiment of the present application.
Icon: 10-a radiopharmaceutical compounding facility; 100-a liquid passing device; 110-a liquid inlet pipe; 111-liquid inlet pipe joint; 120-an intermediate joint; 130-air exhaust mechanism; 131-a first cavity; 132 — a first inlet; 133-a first outlet; 134-a second outlet; 135-evacuation pipe; 136-a first valve; 137-a second valve; 140-a liquid outlet pipe; 141-liquid outlet pipe joint; 200-a generator; 201-a first liquid inlet; 202-a first liquid outlet; 210-a first hollow needle; 220-a second hollow needle; 300-drain; 301-a second cavity; 310-a first elastomer; 320-a first drain pipe; 330-a third valve; 340-a second elastomer; 350-a first liquid inlet cylinder; 360-a sixth valve; 370-a second drain; 380-a second liquid inlet cylinder; 390-third drain; 400-a fourth valve; 410-fifth valve.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present application, it should be noted that the terms "upper", "lower", "inner", "outer", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings or orientations or positional relationships conventionally found in use of products of the application, and are used only for convenience in describing the present application and for simplification of description, but do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
In the description of the present application, it is further noted that, unless expressly stated or limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; either mechanically or electrically. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
Referring to fig. 1 to 3, an embodiment of the present disclosure provides a liquid passing apparatus 100, which includes a liquid inlet pipe 110, an intermediate joint 120, an air exhaust mechanism 130, and a liquid outlet pipe 140.
One end of the liquid inlet pipe 110 is an inlet of the entire liquid passing device 100, and the other end of the liquid inlet pipe 110 is provided with a liquid inlet pipe joint 111.
The intermediate joint 120 is used to connect to the liquid inlet pipe 110 and the air discharge mechanism 130, and one end of the intermediate joint 120 is connected to the liquid inlet pipe joint 111.
The air discharging mechanism 130 has a first cavity 131, one end of the air discharging mechanism 130 is provided with a first inlet 132 communicated with the first cavity 131, the air discharging mechanism 130 is connected to the other end of the intermediate joint 120 through the first inlet 132, the other end of the air discharging mechanism 130 is provided with a first outlet 133 and a second outlet 134 which are independent of each other and respectively communicated with the first cavity 131, the first outlet 133 is provided with an emptying pipe 135, the emptying pipe 135 is communicated with the atmosphere, the emptying pipe 135 is provided with a first valve 136, and the second outlet 134 is provided with a second valve 137.
One end of the liquid outlet pipe 140 has a liquid outlet pipe joint 141, and the air outlet mechanism 130 is connected to the liquid outlet pipe joint 141 through the second outlet 134, and the other end of the liquid outlet pipe 140 is the outlet of the whole liquid passing device 100.
The liquid passing device 100 of the embodiment of the application is used for transferring the radiopharmaceutical liquid prepared by the generator 200 to a penicillin bottle or other containers for containing the radiopharmaceutical liquid, so that splashing of the radiopharmaceutical liquid transferred by a syringe is avoided.
During the use, keep away from the one end of feed liquor pipe 110 and connect in the liquid outlet of generator 200 with feed liquor pipe 110, keep away from the one end of drain pipe 141 with drain pipe 140 and connect in xiLin bottle or other containers that are used for holding radiopharmaceutical liquid to the realization will be transferred to xiLin bottle or other containers that are used for holding radiopharmaceutical liquid through the radiopharmaceutical liquid that the generator 200 made after.
When the radiopharmaceutical liquid enters the liquid passing device 100 from the generator 200, the radiopharmaceutical liquid enters the liquid inlet pipe 110 and the middle joint 120 in sequence, then enters the air discharging mechanism 130 gradually, fills the first cavity 131 gradually, the second valve 137 is closed at the moment, the first valve 136 is opened, air is discharged to the atmosphere from the emptying pipe 135 of the first outlet 133, after the radiopharmaceutical liquid fills the first cavity 131, the first valve 136 is closed, the pressure of the radiopharmaceutical liquid enables the second valve 137 to be opened, and then the radiopharmaceutical liquid flows to the liquid outlet pipe 140 from the second outlet 134.
Optionally, the liquid passing device 100 further comprises a connecting seat.
The connecting seat is a hollow structure, and is sleeved outside the middle joint 120 and the liquid inlet pipe joint 111, so as to stably connect the middle joint 120 and the liquid inlet pipe joint 111.
Optionally, the first valve 136 comprises a float valve.
When the radiopharmaceutical liquid flows to the first valve 136, the float in the float valve floats up, blocking the outlet and closing the valve.
Optionally, the second valve 137 comprises a one-way valve.
Optionally, the liquid passing device 100 further comprises a first cap and a second cap (not shown), the first cap is optionally connected to the other end of the liquid inlet pipe 110, that is, the end of the liquid inlet pipe 110 away from the liquid inlet pipe joint 111; a second cap is optionally attached to the other end of the spout 140, i.e., the end of the spout 140 distal from the spout adapter 141.
When the liquid passing device 100 is not used, the first cover cap and the second cover cap can isolate the flow channel in the liquid passing device 100 from the atmosphere, so that the pollution is avoided. When in use, the first cap and the second cap are taken down.
Referring to fig. 4, the present application further provides a radiopharmaceutical dispensing apparatus 10 including: generator 200, drain 300 and the aforementioned liquid passing device 100.
Referring to fig. 5, a container for holding isotopes is disposed in the generator 200, the generator 200 has a first liquid inlet 201 and a first liquid outlet 202 communicated with the container, and the first liquid inlet 201 and the first liquid outlet 202 are respectively provided with a first hollow needle 210 and a second hollow needle 220.
A drain 300 is provided for draining residual liquid from the generator 200, the drain 300 having a second chamber 301, the bottom of the drain 300 being optionally connected to the second hollow needle 220 to place the second chamber 301 in communication with the container.
The other end of the liquid inlet pipe 110 is optionally connected to a second hollow needle 220.
The vessel containing the raw material is connected to the first hollow needle 210 of the first liquid inlet 201, the raw material passes through the container containing the isotope in the generator 200 to prepare the radiopharmaceutical, and the radiopharmaceutical can be discharged from the second hollow needle 220 of the first liquid outlet 202 and transferred to a penicillin bottle or other container for containing the radiopharmaceutical by the liquid passing device 100 connected to the second hollow needle 220.
Before preparing the radiopharmaceutical, liquid which is not completely discharged in the previous preparation may remain in the generator 200, the liquid discharger 300 is required to suck out the residual liquid in the generator 200, so as to prevent the influence of the residual liquid in the generator 200 on the prepared radiopharmaceutical, and after the residual liquid in the generator 200 is completely sucked, the newly prepared radiopharmaceutical is transferred by the liquid passing device 100.
Referring to fig. 6, in an embodiment of the present application, the liquid discharge device 300 includes a first elastic body 310, the first elastic body 310 has a second cavity 301 therein, and a top of the first elastic body 310 has a first liquid discharge pipe 320 communicating with the second cavity 301. The first elastic body 310 can be deformed to reduce the volume of the second cavity 301 when a pressing force is applied thereto. The bottom of the first elastic body 310 may be directly pressed onto the second hollow needle 220, so that the bottom of the first elastic body 310 is pierced by the second hollow needle 220, and the end of the second hollow needle 220 communicates with the second cavity 301.
Before the residual liquid in the generator 200 is sucked out, a pressing force is applied to the first elastic body 310 to shrink the first elastic body 310, the volume of the second cavity 301 is reduced, the first elastic body 310 is inserted into the second hollow needle 220 while the pressing force is kept unchanged, the second hollow needle 220 is communicated with the second cavity 301, the pressing force is removed, the first elastic body 310 elastically recovers, the second cavity 301 is under negative pressure, and therefore the residual liquid in the generator 200 is sucked into the second cavity 301 and is discharged through the first liquid discharge pipe 320.
Or the first elastic body 310 is directly inserted into the second hollow needle 220, the second hollow needle 220 is communicated with the second cavity 301, and the residual liquid is sucked from the generator 200 to the second cavity 301 by the external suction force and then is discharged by the first liquid discharge pipe 320.
Wherein the external suction force may be provided by a pump connected to the end of the first drain pipe 320.
After the residual liquid in the generator 200 is sucked out, the liquid discharge device 300 may be removed from the second hollow needle 220, and then the liquid inlet pipe 110 of the liquid passing apparatus 100 may be installed on the second hollow needle 220.
Or, the second elastic body 340 is retained on the second hollow needle 220, and the second elastic body 340 is further pressed, so that the top of the second elastic body 340 is continuously pierced by the second hollow needle 220, at this time, the second elastic body 340 is compressed to the bottom of the second hollow needle 220, and the liquid inlet pipe 110 of the liquid passing device 100 is mounted at the top of the second hollow needle 220.
Alternatively, the material of the first elastic body 310 is rubber.
A third valve 330 is disposed in the first drain pipe 320.
Optionally, the third valve 330 is a one-way valve.
Referring to fig. 7, in another embodiment of the present application, the liquid discharge device 300 includes a second elastic body 340 and a first liquid inlet tube 350 engaged with the second hollow needle 220, the second elastic body 340 has a second cavity 301 therein, the top of the second elastic body 340 has a second liquid discharge tube 370 communicating with the second cavity 301, the first liquid inlet tube 350 is connected to the bottom of the second elastic body 340 and communicates with the second cavity 301, and the liquid discharge device 300 is sleeved outside the second hollow needle 220 through the first liquid inlet tube 350 so as to be connected to the second hollow needle 220. The second elastic body 340 can be deformed after being applied with the pressing force, so that the volume of the second cavity 301 is reduced.
Before the residual liquid in the generator 200 is sucked out, a pressing force is applied to the second elastic body 340 to shrink the second elastic body 340, the volume of the second cavity 301 is reduced, the first liquid inlet cylinder 350 is inserted into the second hollow needle 220 while the pressing force is kept unchanged, the pressing force is removed, the elasticity of the second elastic body 340 is restored, the second cavity 301 is subjected to negative pressure, and therefore the residual liquid in the generator 200 is sucked into the second cavity 301 and is discharged through the second liquid discharge pipe 370.
Or the first liquid inlet cylinder 350 is directly inserted into the second hollow needle 220, the second hollow needle 220 is communicated with the second cavity 301, and the residual liquid is sucked from the generator 200 to the second cavity 301 through the external suction force and then is discharged through the second liquid discharge pipe 370.
Wherein the external suction force may be provided by a pump connected to the end of the second drain pipe 370.
After the residual liquid in the generator 200 is sucked out, the liquid discharging device 300 is removed from the second hollow needle 220, and then the liquid inlet pipe 110 of the liquid passing apparatus 100 is installed on the second hollow needle 220.
A sixth valve 360 is disposed within the second drain conduit 370.
Optionally, the sixth valve 360 is a one-way valve.
Referring to fig. 8, in another embodiment of the present application, the liquid discharging device 300 includes a second liquid inlet cylinder 380 matched with the second hollow needle 220, the second liquid inlet cylinder 380 has a second cavity 301, a third liquid discharging pipe 390 communicated with the second cavity 301 is disposed at the bottom of the second liquid inlet cylinder 380, a fourth valve 400 is disposed in the third liquid discharging pipe 390, a fifth valve 410 and a second liquid outlet located at the upper side of the fifth valve 410 are disposed at the top of the second liquid inlet cylinder 380, and the second liquid outlet is connected to the other end of the liquid inlet pipe 110.
The second liquid inlet tube 380 is sleeved outside the second hollow needle 220, the fourth valve 400 is opened, the fifth valve 410 is closed, and the residual liquid is sucked from the generator 200 to the second cavity 301 by external suction force and then discharged by the third liquid discharge tube 390. After the residual liquid in the generator 200 is discharged, the fourth valve 400 is closed, the fifth valve 410 is opened, the vessel containing the raw material is connected to the first hollow needle 210 of the first liquid inlet 201, the raw material passes through the container in which the isotope is placed in the generator 200 to prepare the radiopharmaceutical, and the radiopharmaceutical enters the liquid inlet pipe 110 of the liquid passing device 100 through the second liquid outlet, so that the radiopharmaceutical prepared by the generator 200 is transferred to a penicillin bottle or other containers for containing the radiopharmaceutical.
Wherein the external suction force may be provided by a pump connected to the end of the third drain pipe 390.
In summary, the embodiments of the present application provide a liquid passing device and a radiopharmaceutical preparation apparatus. The solution-passing device 100 can be used to transfer the radiopharmaceutical prepared by the generator 200 into a vial or other container for holding the radiopharmaceutical, thereby preventing the radioactive liquid from splashing when the syringe is used to transfer the radiopharmaceutical. Before the radiopharmaceutical is prepared, liquid which is not completely discharged in the previous preparation may remain in the generator 200, and the liquid discharger 300 is required to suck out the residual liquid in the generator 200, so as to avoid the influence of the liquid remaining in the generator 200 on the prepared radiopharmaceutical.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A liquid passing apparatus, comprising:
a liquid inlet pipe;
the air discharging mechanism is provided with a first cavity, one end of the air discharging mechanism is provided with a first inlet communicated with the first cavity, the air discharging mechanism is connected to one end of the liquid inlet pipe through the first inlet, the other end of the air discharging mechanism is provided with a first outlet and a second outlet which are mutually independent and communicated with the first cavity, the first outlet is provided with an emptying pipe communicated with the atmosphere, the emptying pipe is provided with a first valve, and the second outlet is provided with a second valve;
one end of the liquid outlet pipe is connected to the second outlet;
the first valve comprises a float valve and the second valve comprises a one-way valve.
2. The liquid passing device of claim 1, comprising an intermediate joint, wherein one end of the liquid inlet pipe is connected to one end of the intermediate joint, and one end of the intermediate joint is connected to the first inlet.
3. A liquid passing device according to claim 2, wherein one end of the liquid inlet pipe is provided with a liquid inlet pipe joint, one end of the liquid outlet pipe is provided with a liquid outlet pipe joint, the liquid inlet pipe is connected to one end of the intermediate joint through the liquid inlet pipe joint, and the liquid outlet pipe is connected to the second outlet through the liquid outlet pipe joint.
4. The liquid passing device according to any one of claims 1 to 3, further comprising a first cap and a second cap, wherein the first cap is optionally connected to the other end of the liquid inlet pipe, and the second cap is optionally connected to the other end of the liquid outlet pipe.
5. A radiopharmaceutical dispensing apparatus, comprising:
the isotope supply device comprises a generator, a first liquid inlet and a second liquid outlet, wherein the generator is internally provided with a container for placing isotopes, the generator is provided with a first liquid inlet and a first liquid outlet which are communicated with the container, and the first liquid inlet and the first liquid outlet are respectively provided with a first hollow needle head and a second hollow needle head;
a drain for draining residual liquid from the generator, the drain having a second cavity, the bottom of the drain being selectively connectable to the second hollow needle to place the second cavity in communication with the container;
the liquid passing device of any one of claims 1 to 4, wherein the other end of the liquid inlet pipe is optionally connected to the second hollow needle.
6. A radiopharmaceutical dispensing apparatus as set forth in claim 5 wherein the liquid drain comprises a first elastomer having the second cavity therein, the first elastomer having a first liquid drain tube at a top portion thereof in communication with the second cavity, the first elastomer having a bottom portion pierceable by the second hollow needle to place the second cavity in communication with the second hollow needle.
7. A radiopharmaceutical dispensing apparatus as set forth in claim 6 wherein a third valve is disposed in said first drain line.
8. The radiopharmaceutical dispensing apparatus of claim 5, wherein the liquid discharger comprises a second elastic body and a first liquid inlet tube engaged with the second hollow needle, the second elastic body has the second cavity therein, the top of the second elastic body has a second liquid discharge tube communicated with the second cavity, the first liquid inlet tube is connected to the bottom of the second elastic body and communicated with the second cavity, and the liquid discharger can be sleeved outside the second hollow needle through the first liquid inlet tube so as to be connected to the second hollow needle.
9. The radiopharmaceutical dispensing apparatus of claim 5, wherein the liquid discharging device comprises a second liquid inlet tube coupled to the second hollow needle, the second liquid inlet tube has the second cavity, a third liquid discharging tube is disposed at a bottom of the second liquid inlet tube and communicates with the second cavity, a fourth valve is disposed in the third liquid discharging tube, a fifth valve is disposed at a top of the second liquid inlet tube, and a second liquid outlet is disposed at an upper side of the fifth valve and is connected to the other end of the liquid inlet tube.
10. A radiopharmaceutical dispensing apparatus as set forth in any one of claims 5 to 9 further comprising a pump connected to the drain.
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| CN202010869429.XA CN112043592A (en) | 2020-08-26 | 2020-08-26 | Liquid passing device and radiopharmaceutical preparation equipment |
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| CN202010869429.XA CN112043592A (en) | 2020-08-26 | 2020-08-26 | Liquid passing device and radiopharmaceutical preparation equipment |
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