CN112040793A - Powder formulation - Google Patents

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Publication number
CN112040793A
CN112040793A CN201980027791.8A CN201980027791A CN112040793A CN 112040793 A CN112040793 A CN 112040793A CN 201980027791 A CN201980027791 A CN 201980027791A CN 112040793 A CN112040793 A CN 112040793A
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powder composition
powder
composition
iii
composition according
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CN112040793B (en
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安德里亚·布尔巴瑞洛
斯蒂芬妮·盖尔森
托马斯·林德曼
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DSM IP Assets BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A23L29/219—Chemically modified starch; Reaction or complexation products of starch with other chemicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/654—The particulate/core comprising macromolecular material

Abstract

The present invention relates to a powder formulation comprising at least one fat-soluble vitamin, which can be easily produced and can be used in many fields of application.

Description

Powder formulation
The present invention relates to a powder formulation comprising at least one fat-soluble vitamin, which can be easily produced and can be used in many fields of application.
Examples of fat-soluble vitamins are "vitamins A, D, E and K and their derivatives, such as vitamin a esters (e.g. vitamin a acetate and vitamin a palmitate) and vitamin E esters (e.g. tocopherol acetate).
Solid powder formulations comprising at least one fat-soluble vitamin need to be stable and easy to produce. Furthermore, the formulation should also be easy to handle, which means that the flowability of the formulation should be good.
It has surprisingly been found that powder compositions comprising at least two different kinds of maltodextrins have improved properties.
A surprising advantage of the powder composition according to the invention is that the composition is not sticky (even during drying, which is usually done by spray drying). The composition does not adhere to the walls of the drying apparatus. Thus, material loss during production is reduced and the time for cleaning is shortened. In addition, the novel formulations also have excellent flow properties.
The present invention therefore relates to a powder composition (I) comprising
(i) Up to 70 weight percent (wt-%), based on the total weight of the powder composition, of at least one fat-soluble vitamin, and
(ii) 5-30 wt-%, based on the total weight of the powder composition, of at least one D-glucose oligomer of DE <18 (preferably maltodextrin) (GO1), and
(iii) 5-30 wt-%, based on the total weight of the powder composition, of at least one D-glucose oligomer of DE >18 (preferably maltodextrin) (GO2), and
(iv) 5-70 wt-%, based on the total weight of the powder composition, of at least one modified polysaccharide.
It is obvious that the percentages always sum to 100.
The composition according to the invention is a dry powder. However, it may also contain some water originating from the emulsion. Typically and preferably, the water content is less than 5 wt-%, based on the total weight of the powder composition. Typically less than 4 wt-%.
Preferably, the at least one fat-soluble vitamin is selected from the group consisting of: vitamins A, D, E and K and their derivatives.
More preferably, the at least one fat soluble vitamin is selected from the group consisting of vitamin a esters (e.g. vitamin a acetate and vitamin a palmitate) and vitamin E esters (e.g. tocopherol acetate).
Accordingly, the present invention relates to a powdered composition (II), which is a powdered composition (I), wherein at least one fat-soluble vitamin is selected from the group consisting of: vitamins A, D, E and K and their derivatives.
The present invention therefore relates to a powderous composition (II'), which is a powder composition (I) or (II), wherein the at least one fat-soluble vitamin is selected from the group consisting of vitamin a esters (e.g. vitamin a acetate and vitamin a palmitate) and vitamin E esters (e.g. tocopherol acetate, especially dl-alpha-tocopherol acetate).
The powder formulation comprises at most 70 wt-%, based on the total weight of the powder formulation, of at least one fat-soluble vitamin.
The powder formulation may also comprise less than about 0.1 wt-% of at least one fat-soluble vitamin, based on the total weight of the formulation.
Preferably, the powder formulation comprises 1-60 wt-%, based on the total weight of the powder formulation, of at least one fat-soluble vitamin.
Accordingly, the present invention relates to a powder composition (III) which is a powder composition (I), (II) or (II'), wherein the powder formulation comprises 0.1-70 wt-%, based on the total weight of the powder formulation, of at least one fat-soluble vitamin.
Accordingly, the present invention relates to a powder composition (III ') which is a powder composition (I), (II) or (II'), wherein the formulation comprises 1-60 wt-%, based on the total weight of the powder formulation, of at least one fat-soluble vitamin.
Furthermore, the powder composition according to the invention comprises two different kinds of D-glucose oligomers (preferably maltodextrin). The two different classes of D-glucose oligomers (preferably maltodextrins) differ in their DE values.
Dextrose Equivalent (DE) is a measure of the amount of reducing sugars present in a sugar product relative to glucose, expressed as a percentage on a dry basis. For example, maltodextrin with a DE of 10 will have 10% of the reducing power of dextrose (DE of 100). Maltose, a disaccharide made from two molecules of glucose (dextrose), has a DE of 52, correcting for water loss of molecular weight when the two molecules are combined (180/342). Sucrose, although a disaccharide, actually has a DE of 0, has no remaining reducing groups because the two reducing groups of the monosaccharide from which it is made are linked. For solutions made from starch, the DE is an estimate of the percentage of reducing sugars present in the total starch product.
In all glucose polymers, from native starch to glucose syrup, the molecular chain starts with reducing sugars containing free aldehydes. As starch is hydrolyzed, the molecules become shorter and more reducing sugars are present. Since different reducing sugars (e.g. fructose and glucose) have different sweetness, it is incorrect to assume that there is any direct relationship between DE and sweetness.
DE describes the extent of starch conversion to glucose:
the starch is close to DE-0,
the glucose/dextrose is DE 100 (percent).
The standard method for DE determination is blue-einon (Lane-Eynon) titration, which is based on the reduction of copper (II) sulfate in alkaline tartrate solution, an application of the Fehling's test.
For the present invention, the DE of the first D-glucose oligomer (preferably maltodextrin) (or a mixture thereof) which is component (ii) of the formulation and is defined as (GO1) is less than 18, preferably less than 15, more preferably less than 12, even more preferably less than 10.
Most preferably, the first D-glucose oligomer (preferably maltodextrin) (or mixture thereof) as component (ii) of the formulation has a DE of from 2 to 10.
The present invention therefore relates to a powder composition (IV) which is a powder composition (I), (II '), (III) or (III'), wherein the DE of the mixture of (GO1) or (GO1) is less than 15.
The present invention therefore relates to a powder composition (IV ') which is a powder composition (I), (II '), (III) or (III '), wherein the DE of the mixture of (GO1) or (GO1) is less than 12.
The present invention therefore relates to a powder composition (IV ") which is a powder composition (I), (II '), (III) or (III'), wherein the DE of the mixture of (GO1) or (GO1) is less than 10.
The present invention therefore relates to a powder composition (IV ' ") which is a powder composition (I), (II '), (III) or (III '), wherein the DE of the mixture of (GO1) or (GO1) is from 2 to 10.
For the present invention, the DE of the second D-glucose oligomer (preferably maltodextrin) (or a mixture thereof) which is ingredient (iii) of the formulation and is defined as (GO2) is greater than 18, preferably greater than 20.
Most preferably, the second D-glucose oligomer (or mixture thereof) as component (iii) of the formulation has a DE of from 20 to 45.
The present invention therefore relates to a powder composition (V) which is a powder composition (I), (II '), (III'), (IV '), (IV ") or (IV'"), wherein the DE of the mixture of (GO2) or (GO2) is greater than 20.
The present invention therefore relates to a powder composition (V ') which is a powder composition (I), (II '), (III '), (IV '), (IV ") or (IV '"), wherein the DE of the mixture of (GO2) or (GO2) is from 20 to 45.
As mentioned above, (GO1) and (GO2) can be used in the same amount (1:1 mixture) as well as in different amounts.
The composition according to the invention comprises at least one modified polysaccharide.
Preferably, the modified polysaccharide is a modified starch.
Accordingly, the present invention relates to a powder composition (VI) which is a powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V) or (V '), wherein the modified polysaccharide is a modified starch.
Preferably, the modified polysaccharide has formula (I)
Figure BDA0002739154430000041
Wherein
St is a starch, and St is,
r is an alkylene group and R' is a hydrophobic group.
The present invention therefore relates to a powder composition (VI ') which is a powder composition (I), (II'), (III '), (IV'), (IV "), (IV '"), (V) or (V'), wherein the modified polysaccharide has the formula (I),
Figure BDA0002739154430000051
wherein
St is a starch, and St is,
r is an alkylene group and R' is a hydrophobic group.
Preferably, the modified polysaccharide is sodium starch octenyl succinate.
Accordingly, the present invention relates to a composition (VI ") which is a powder composition (I), (II '), (III '), (IV '), (IV"), (IV ' "), (V) or (V '), wherein the modified polysaccharide is starch sodium octenyl succinate.
Preferably, the powder compositions (I), (II '), (III'), (IV '), (IV "), (IV'"), (V '), (VI') and (VI ") according to the invention have an average internal particle diameter D [0,5] (internal phase) of less than 500nm, preferably from 150nm to 450 nm.
In the context of the present patent application, all sizes of the internal phase D [0,5] are determined by using Mastersizer 2000. After redispersing the powder composition in water, the particle size of the internal phase is determined.
The invention therefore relates to a powder composition (VII) which is a powder composition (I), (II '), (III'), (IV '), (IV "), (IV'"), (V '), (VI') or (VI "), wherein the powder composition has an average internal particle diameter D [0,5] (internal phase) of less than 500 nm.
The invention therefore relates to a powder composition (VII ') which is a powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI ') or (VI "), wherein the powder composition has an average internal particle diameter D [0,5] (internal phase) of from 150nm to 450 nm.
Preferably, the powder composition according to the invention is a spray-dried composition. Other production methods may also be used.
Accordingly, the present invention relates to a composition (VIII) which is a powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI '), (VI "), (VII) or (VII '), wherein the powder composition is a spray-dried composition.
The powder composition according to the invention can be produced by using techniques known to the person skilled in the art.
In a first step, an emulsion comprising all ingredients ((i) - (iv)) and water is produced, and then the emulsion is dried (typically and preferably by spray drying). The water content of the powder composition depends on the conditions of the drying process applied.
An advantage of the powder composition according to the invention is that during the spray-drying process the powder composition is not sticky, and therefore the powder composition does not stick to the walls of the spray-drying tower, and therefore the loss of powder composition during the drying process is very low and the effort to clean the drying equipment is reduced.
The present invention therefore relates to a process for the production of powder compositions (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI '), (VI "), (VII ') or (VIII), characterized in that in a first step an emulsion is produced comprising all components (I) - (IV) and water, and that in a second step the emulsion is dried to form the powder composition.
The powder compositions (I), (II '), (III '), (IV '), (IV "), (IV '), (V '), (VI '), (VII ') and (VIII) according to the invention are used in food, feed and/or personal care formulations.
Preferably, the powder compositions (I), (II '), (III '), (IV '), (IV '), (V '), (VI '), (VII ') and (VIII) are used in liquid formulations, preferably in beverages.
Furthermore, the present invention relates to food, feed and personal care formulations comprising at least one pulverulent composition (I), (II '), (III'), (IV '), (V'), (VI '), (VII') and/or (VIII).
These formulations may be in any form. Solid, liquid or gel-like.
Preferred are liquid food, feed and personal care formulations comprising at least one powder composition (I), (II '), (III'), (IV '), (V'), (VI '), (VII') and/or (VIII).
More preferred are beverages comprising at least one powder composition (I), (II '), (III'), (IV '), (V'), (VI '), (VII') and/or (VIII).
Accordingly, another embodiment of the present invention relates to food, feed and personal care formulations comprising at least one powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI '), (VI "), (VII ') and/or (VIII).
Accordingly, another embodiment of the present invention relates to liquid food, feed and personal care formulations comprising at least one powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI '), (VI "), (VII ') and/or (VIII).
Accordingly, another embodiment of the present invention relates to a beverage comprising at least one powder composition (I), (II '), (III '), (IV '), (IV "), (IV '"), (V '), (VI '), (VI "), (VII ') and/or (VIII).
The concentration of the powder composition in food, feed and/or personal care formulations depends on the kind of these formulations.
The attached drawings are as follows:
FIG. 1: flowability test of the compositions of example 1 and example 2 (comparative).
The invention is illustrated by the following examples. All temperatures are expressed in degrees Celsius and all parts and percentages relate to weight.
Example 1(dl- α -tocopherol acetate):
109g of Capsul HS (modified food starch), 54.6g of Glucidex 6 (maltodextrin with DE between 5 and 8) and 54.6g of Glucadry 210 (maltodextrin with DE between 20 and 23) were placed in a 1.5 liter reaction vessel and dispersed in 185g of deionized water at room temperature. The temperature was raised to 65 ℃ with stirring using a mini-disc (2000rpm, d ═ 6 cm). The solution was held at 65 ℃ for 60 minutes.
239.6g dl-alpha-tocopherol acetate were preheated to 65 ℃ and added to the mixture of Capsul HS, Glucadrex 6 and Glucadry 210 with water over 5-10 minutes and homogenized using a mini-disc (6000 rpm). At the same time, 91 grams of water was added to the emulsion over 5-10 minutes. The emulsion was homogenized using a mini disc (6000rpm) for an additional 30 minutes at 65 ℃.
The emulsion is then dried in a spray drying process (emulsion temperature: 65 ℃). The temperature at the inlet of the spray drying tower is between 180 ℃ and 183 ℃, and the temperature at the outlet of the spray drying tower is between 90 ℃ and 100 ℃.
A powdery composition having a residual moisture content of 3.0% or less is obtained. The size of the internal phase D [0,5] is 380 nm.
The following table shows the amounts of the ingredients of the composition (recalculated values for anhydrous compositions).
Table 1: formulation composition of example 1
Composition (I) Amount [% ]]
Capsul HS 23.8
Glucidex 6 11.9
Glucodry 210 11.9
dl-alpha-tocopherol acetate 52.4
Example 2: (comparative example)
109g of Capsul HS (modified food starch), 109g of Glucrosdry 210 (maltodextrin with a DE between 20 and 23) were placed in a 1.5 liter reaction vessel and dispersed in 185g of deionized water at room temperature. The temperature was raised to 65 ℃ with stirring using a mini-disc (2000rpm, d ═ 6 cm). The solution was held at 65 ℃ for 60 minutes.
239.6g dl-alpha-tocopheryl acetate was preheated to 65 ℃ and added to the mixture of Cleargum, Glucody 210 and water over 5-10 minutes and homogenized using a mini disc (6000 rpm). At the same time, 91 grams of water was added to the emulsion over 5-10 minutes. The emulsion was homogenized using a mini disc (6000rpm) for an additional 30 minutes at 65 ℃.
The emulsion is then dried in a spray drying process (emulsion temperature: 65 ℃). The temperature at the inlet of the spray drying tower is between 180 ℃ and 183 ℃, and the temperature at the outlet of the spray drying tower is between 90 ℃ and 100 ℃.
A powdery composition having a residual moisture content of 3.0% or less is obtained. The size of the internal phase D [0,5] is 380 nm.
The following table shows the amounts of the ingredients of the composition (recalculated values for anhydrous compositions).
Table 2: formulation composition of example 2
Composition (I) Amount [% ]]
Capsul HS 23.8
Glucodry 210 23.8
dl-alpha-tocopherol acetate 52.4
Example 3: (vitamin A acetate)
155g of Cleargum C OA1 (modified food starch), 76.1g of Glucidex 6, 76.1g of Glucody 210 (maltodextrin, DE between 20 and 23) and 7g of sodium ascorbate were placed in a 1.5 liter reaction vessel and dispersed in 265 g of deionized water at room temperature. The temperature was raised to 65 ℃ with stirring using a mini-disc (2000rpm, d ═ 6 cm). The solution was kept at 65 ℃ for 60 minutes.
35 grams of vitamin A acetate and 3.5 grams of dl-alpha-tocopherol were preheated to 65 ℃ and added to a mixture of Capsul HS, Glucodry 210, sodium ascorbate and water over a period of 5-10 minutes and homogenized with a mini-disc (6000 rpm). The emulsion was homogenized at 65 ℃ for a further 30 minutes using a mini-disc (6000 rpm).
Thereafter, the emulsion was dried in a spray drying process (emulsion temperature: 65 ℃ C.). The temperature at the inlet of the spray drying tower is between 180 ℃ and 183 ℃, and the temperature at the outlet of the spray drying tower is between 90 ℃ and 100 ℃.
The residual moisture content of the obtained powder composition is less than or equal to 3.0 percent. The size of the internal phase D [0,5] is 300 nm.
The following table shows the amounts of the ingredients of the composition (recalculated values for anhydrous compositions).
Table 3: formulation composition of example 3
Composition (I) Amount [% ]]
Cleargum 43.5
Glucidex 6 21.7
Glucodry 210 21.7
Ascorbic acid sodium salt 2
Vitamin A acetate 10.1
dl-alpha-tocopherol acetate 1
To show how the flowability of the composition according to the invention is improved, the flowability is measured as described below.
Fluidity measurement
FT4 Powder
Figure BDA0002739154430000101
(Freeman Instruments, uk) is an instrument capable of characterizing the rheology or flowability of powders. One of the tests that the above-mentioned apparatus can perform is the so-called "gassing test", in which the cohesion of the powder to be analyzed is quantified. Cohesion is the combination of van der waals and electrostatic forces and tends to "bind" the particles together. Thus, the higher the cohesion measured, the poorer the flowability of the powder to be analyzed.
The measured flow resistance (inflation energy (AE)) quantifies the strength of the cohesion.
For powders with weak cohesion, the inflation energy tends to zero as the powder becomes fully aerated. Moderate to high cohesion powders exhibit a reduction in flow energy upon aeration, but to a much lesser extent. In these sticky powders, the stretching force is too great for air to overcome and the particles do not separate.
The composition of example 1 showed a total aeration energy value of 750mJ when the wind speed was set to 6mm/s, while the composition of comparative example (example 2) showed a value of 1300 under the same wind speed conditions.
The results will also be seen in the figure.
The method comprises the following steps:
a standard amount of powder was poured into a specially designed sample holder (Freeman Technology, uk). The bottom of the sample holder is porous and allows air to pass through and fill the powder in the cylindrical sample holder in a controlled manner.
After sample preparation, airflow was initiated and the rotating propeller was lowered into the aerated powder.
Then, a particular hardware unit will provide higher and higher air velocities.

Claims (10)

1. A powder composition (I) comprising
(i) Up to 70 weight percent (wt-%), based on the total weight of the powder composition, of at least one fat-soluble vitamin, and
(ii) 5-30 wt-%, based on the total weight of the powder composition, of at least one D-glucose oligomer of DE <18 (preferably maltodextrin) (GO1), and
(iii) 5-30 wt-%, based on the total weight of the powder composition, of at least one D-glucose oligomer of DE >18 (preferably maltodextrin) (GO2), and
(iv) 5-70 wt-%, based on the total weight of the powder composition, of at least one modified polysaccharide.
2. The powder composition according to claim 1, wherein the at least one fat-soluble vitamin is selected from the group consisting of: vitamins A, D, E and K and their derivatives.
3. The powder composition according to any one of the preceding claims, wherein the powder formulation comprises 0.1-70 wt-%, based on the total weight of the powder formulation, of the at least one fat-soluble vitamin.
4. The powder composition according to any preceding claim, wherein the DE of (GO1) or the mixture of (GO1) is less than 15.
5. The powder composition according to any preceding claim, wherein the DE of (GO1) or the mixture of (GO1) is from 2 to 10.
6. The powder composition according to any preceding claim, wherein the DE of (GO2) or the mixture of (GO2) is greater than 20.
7. The powder composition according to any preceding claim, wherein the DE of (GO2) or the mixture of (GO2) is from 20 to 45.
8. The powder composition according to any one of the preceding claims, wherein the modified polysaccharide is a modified starch.
9. The powder composition according to any preceding claim, wherein the modified polysaccharide has formula (I)
Figure FDA0002739154420000021
Wherein
St is a starch, and St is,
r is an alkylene group and R' is a hydrophobic group.
10. A food, feed and personal care formulation comprising at least one powder composition according to any of the preceding claims.
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US20090105331A1 (en) * 2006-02-06 2009-04-23 David Schaffner Compositions of active ingredients
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US20110305740A1 (en) * 2009-03-02 2011-12-15 Roquette Freres Granulated powder containing vegetable proteins and maltodextrins, process for producing same, and uses thereof
CN105188415A (en) * 2013-05-06 2015-12-23 帝斯曼知识产权资产管理有限公司 Powderous vitamin E formulation
WO2017097974A1 (en) * 2015-12-10 2017-06-15 Dsm Ip Assets B.V. Vitamin formulation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1324576C (en) * 1987-10-02 1993-11-23 Paula Sue Kirk Process for making a spray-dried, directly- compressible vitamin powder comprising unhydrolyzed gelatin
US20060159805A1 (en) * 2003-07-15 2006-07-20 Elger Funda Powderous formulations of fat-soluble active ingredients
US20090105331A1 (en) * 2006-02-06 2009-04-23 David Schaffner Compositions of active ingredients
CN101754692A (en) * 2007-07-19 2010-06-23 罗盖特公司 Use of pea maltodextrin and/or of pea glucose syrup for encapsulating hydrophobic compounds
US20100284987A1 (en) * 2007-07-19 2010-11-11 Dsm Ip Assets B.V. Tablettable formulations of lipophilic health ingredients
US20110305740A1 (en) * 2009-03-02 2011-12-15 Roquette Freres Granulated powder containing vegetable proteins and maltodextrins, process for producing same, and uses thereof
CN105188415A (en) * 2013-05-06 2015-12-23 帝斯曼知识产权资产管理有限公司 Powderous vitamin E formulation
WO2017097974A1 (en) * 2015-12-10 2017-06-15 Dsm Ip Assets B.V. Vitamin formulation

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