CN112033069A

CN112033069A - Genetic engineering bacterin is with cold-stored transfer device

Info

Publication number: CN112033069A
Application number: CN202010912803.XA
Authority: CN
Inventors: 任海涛; 吴浩飞; 陈晓芬; 冷文娜; 印露; 高翔
Original assignee: AB&B Bio Tech Co Ltd JS
Current assignee: Jiangsu Zhonghui Yuantong Biotechnology Co ltd
Priority date: 2020-09-02
Filing date: 2020-09-02
Publication date: 2020-12-04
Anticipated expiration: 2040-09-02
Also published as: CN112033069B; WO2022048528A1

Abstract

The invention discloses a cold storage transfer device for genetic engineering vaccines, relating to the technical field of genetic engineering; the vaccine heat-preservation transfer device aims to solve the problem that the existing vaccine heat-preservation transfer device is a box body made of common heat-preservation materials and only has a simple heat-preservation and heat-insulation effect, so that the vaccine in the device can be inactivated or damaged; the refrigerator comprises a frame, the top fixed mounting of frame has the cold insulation case, and the inside fixed mounting of cold insulation case has two division boards, is provided with cold airflow channel between two division boards, the bottom fixed mounting of frame has the gyro wheel of taking the service brake, the inside fixed mounting of frame has refrigeration mechanism. According to the invention, the cold flow pipe mechanism is inserted into the rectangular slot at the bottom end of the storage box mechanism, and the cold flow is guided into the cold flow pipe mechanism by the extrusion valve on the inner wall of the rectangular slot to rapidly cool the storage box mechanism, each cold-insulation cavity is independent and not interfered with each other, and other vaccines cannot be interfered in the feeding and discharging processes.

Description

Genetic engineering bacterin is with cold-stored transfer device

Technical Field

The invention relates to the technical field of genetic engineering, in particular to a cold storage transfer device for genetic engineering vaccines.

Background

The increasingly diverse studies on genes have finally allowed people to take the gene out of the chromosome and then put it in another place or transfer it into another organism. This is a DNA in vitro recombination technique, also known as genetic engineering. Genetic engineering refers to carefully designing schemes for changing the genetic characteristics of organisms in advance according to the rules of genetic variation of the organisms, purposefully modifying the organisms, directionally inserting natural or artificially synthesized genetic materials into bacteria, yeasts or mammalian cells by using a DNA recombinant biotechnology to enable the natural or artificially synthesized genetic materials to be fully expressed, and purifying to obtain the vaccine. By applying gene engineering technology, subunit vaccine, stable attenuated vaccine and multivalent vaccine capable of preventing several diseases can be prepared.

The storage temperature range of the vaccine is between 2 ℃ and 8 ℃, the efficacy of the vaccine can be influenced no matter the storage temperature is too high or too low, so that the vaccine cannot achieve the due prevention effect, and the existing vaccine heat-preservation transfer device is a box body made of common heat-preservation materials and only has the simple heat-preservation and heat-insulation effects, so that the vaccine in the device can be inactivated or damaged.

Disclosure of Invention

Based on the technical problems in the background art, the invention provides a refrigeration transfer device for a genetic engineering vaccine.

The invention provides a cold storage transfer device for genetic engineering vaccines, which comprises a rack, wherein a cold insulation box is fixedly arranged at the top end of the rack, two isolation plates are fixedly arranged inside the cold insulation box, a cold air flow channel is arranged between the two isolation plates, a roller with a foot brake is fixedly arranged at the bottom of the rack, a refrigeration mechanism is fixedly arranged inside the rack, an evaporation pipe forming a loop is fixedly arranged on the side surface of the refrigeration mechanism, the end part of the evaporation pipe extends into the cold air flow channel, a plurality of cold insulation cavities are respectively arranged on the two sides of the cold insulation box, a storage box mechanism is inserted inside the cold insulation cavities, a sealing plate is arranged on the outer side of each cold insulation cavity through a hinge and a snap lock, a cold flow pipe mechanism with a U-shaped structure is fixedly arranged at the bottom end inside each cold insulation cavity, a valve is fixedly arranged between the end part of the cold flow pipe mechanism and the evaporation pipe, and a rectangular slot is arranged at the bottom end inside the storage, and the cold flow pipe mechanism is inserted in the rectangular slot, and the end part of the storage box mechanism is provided with a handle part.

Preferably, the refrigeration mechanism comprises a refrigeration compressor, a condenser, a throttle valve and an evaporator, the refrigeration compressor, the condenser, the throttle valve and the evaporator are sequentially connected through pipelines, and an evaporation pipe is installed at the end part of the evaporator.

Preferably, a plurality of cold conduction plates are fixedly installed between the top ends of the cold flow pipe mechanisms, and a plurality of strip-shaped grooves are formed in the tops of the cold conduction plates.

Preferably, store box mechanism and include the box body, and the top fixed mounting of box body has the lid, and the bottom of box body is provided with a plurality of air conditioning slotted holes that are linked together with the rectangle slot.

Preferably, a plurality of sponge plates are fixedly installed between the inner walls of the two sides of the box body, and a plurality of arc-shaped notches are formed in the two sides of each sponge plate.

Preferably, the bottom fixed mounting of box body has the thermal-insulated diaphragm of a plurality of flexible materials, and thermal-insulated diaphragm crisscross distribution in the inside of rectangle slot.

Preferably, the bottom and the top of the handle part are both provided with sliding grooves, the handle plates with L-shaped sections are arranged in the two sliding grooves in a sliding mode, and the inner walls of the top and the bottom of the cold insulation cavity are both provided with self-locking grooves matched with the handle plates.

Preferably, the magnetic steel plate is fixedly installed in the middle of the handle portion, and the magnetic plates which are mutually repelled with the magnetic steel plate are fixedly installed on the sides, close to each other, of the two handle plates.

Preferably, a storage battery pack is fixedly mounted inside the frame.

Preferably, the side face of the sealing plate is fixedly provided with a limiting convex rod, and the bottom and the top of the limiting convex rod are both provided with arc-shaped grooves matched with the handle plate.

According to the invention, a plurality of relatively independent cold insulation cavities are distributed on two sides of the cold insulation box in the device, the vaccines can be classified and placed in the storage box mechanism in the transferring process of the vaccines and inserted into the cold insulation cavities, so that the cold flow pipe mechanism is inserted into the rectangular slot at the bottom end of the storage box mechanism, the cold flow is guided into the cold flow pipe mechanism by the extrusion valve on the inner wall of the rectangular slot to rapidly cool the storage box mechanism, each cold insulation cavity is independent and not interfered with each other, other vaccines cannot be interfered in the feeding and discharging process, and the safety of the device in the transferring process of the vaccines in cold insulation is improved;

after the storage box mechanism is inserted, the cold flow pipe mechanism absorbs heat inside the cold insulation cavity, so that cold insulation storage and transportation of vaccines placed inside are performed, when the vaccines are placed, the vaccine box is directly inserted between two adjacent sponge plates, effective buffer protection is provided for the vaccines by using elasticity of the sponge plates, and safety in the vaccine transportation process is further improved;

store box mechanism and insert to keeping cold intracavity portion back, the tip of handle board can insert to the inside of auto-lock groove, locks storing box mechanism, has avoided the pine phenomenon that takes off that can appear among the transfer process, further improves the security of device to bacterin transfer process.

Drawings

FIG. 1 is a schematic cross-sectional view of a refrigerated transport device for genetically engineered vaccines according to the present invention;

FIG. 2 is a structural diagram of a storage box mechanism of a refrigeration transfer device for genetic engineering vaccines according to the present invention;

FIG. 3 is a schematic structural diagram of a side view of a storage box mechanism of a refrigerated transport device for genetically engineered vaccines according to the present invention;

FIG. 4 is a schematic diagram of a cold conducting plate structure of a cold storage transfer device for a genetically engineered vaccine according to the present invention;

FIG. 5 is a schematic diagram of a structure of a limiting protruding rod of a refrigeration transfer device for genetic engineering vaccines according to the present invention.

In the figure: 1 frame, 2 storage battery packs, 3 rectangular slots, 4 cold air channels, 5 cold flow pipe mechanisms, 6 valves, 7 isolation plates, 8 cold guide plates, 9 self-locking grooves, 10 handle plates, 11 handle parts, 111 magnetic steel plates, 12 sealing plates, 121 limiting convex rods, 13 storage box mechanisms, 131 box bodies, 132 box covers, 133 sponge plates, 134 cold air slotted holes, 135 heat insulation membranes, 14 cold insulation boxes, 15 evaporation pipes and 16 refrigeration mechanisms.

Detailed Description

Reference will now be made in detail to embodiments of the present patent, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present patent and are not to be construed as limiting the present patent.

In the description of this patent, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for the convenience of describing the patent and for the simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the patent.

In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed. The specific meaning of the above terms in this patent may be understood by those of ordinary skill in the art as appropriate.

Example 1

Referring to fig. 1-4, a cold storage transfer device for genetic engineering vaccines comprises a frame 1, a cold insulation box 14 is fixedly installed at the top end of the frame 1, two isolation plates 7 are fixedly installed inside the cold insulation box 14, a cold air flow channel 4 is arranged between the two isolation plates 7, a roller with a foot brake is fixedly installed at the bottom of the frame 1, a refrigeration mechanism 16 is fixedly installed inside the frame 1, an evaporation tube 15 forming a loop is fixedly installed on the side surface of the refrigeration mechanism 16, the end portion of the evaporation tube 15 extends into the cold air flow channel 4, a plurality of cold insulation chambers are arranged on both sides of the cold insulation box 14, a storage box mechanism 13 is inserted into the cold insulation chambers, a sealing plate 12 is installed on the outer side of each cold insulation chamber through a hinge and a snap lock, a cold flow tube mechanism 5 with a U-shaped structure is fixedly installed at the bottom end of each cold insulation chamber, and a valve 6 is fixedly installed between the end portion of the cold flow tube mechanism 5 and the evaporation, store the inside bottom of box mechanism 13 and be provided with rectangle slot 3, and cold flow tube mechanism 5 pegs graft in the inside of rectangle slot 3, the tip of storing box mechanism 13 is provided with handle portion 11, a plurality of relatively independent cold insulation chambeies of cold insulation box 14 both sides distribution in the device, can place its classification in the inside of storing box mechanism 13 at the in-process of bacterin transportation, inside inserting cold insulation chamber, and then make cold flow tube mechanism 5 insert to store inside the rectangle slot 3 of box mechanism 13 bottom, and 3 inner wall extrusion valves 6 of rectangle slot carry out rapid cooling with cold flow leading-in to cold flow tube mechanism 5 inside to storing box mechanism 13, every cold insulation chamber mutual independence and mutual noninterference, can not cause the interference to other bacterins at last unloading in-process, the security of device to the cold-stored transportation in-process of bacterin is improved.

In the invention, the refrigerating mechanism 16 comprises a refrigerating compressor, a condenser, a throttle valve and an evaporator which are sequentially connected through pipelines, the evaporating pipe 15 is arranged at the end part of the evaporator, a liquid refrigerant is vaporized into low-temperature low-pressure steam after absorbing heat of a cooled object in the evaporator, the low-temperature low-pressure steam is sucked by the compressor, the high-temperature high-pressure steam is compressed into high-pressure high-temperature steam and then is discharged into the condenser, heat is released to a cooling medium in the condenser, the high-pressure liquid is condensed into high-pressure liquid, the low-pressure low-temperature refrigerant is throttled by the throttle valve and enters the evaporator again to absorb heat for vaporization, the purpose of circulating refrigeration.

A plurality of cold drawing 8 of leading of fixed mounting between the top of cold flow pipe mechanism 5, and the top of leading cold drawing 8 is provided with a plurality of bar grooves, leads cold drawing 8 at the top surface mounting of cold flow pipe mechanism 5, stores box mechanism 13 and can increase the area of contact between air and the cold flow pipe mechanism 5 after inserting, and then accelerates temperature reduction rate.

Store box mechanism 13 and include box body 131, and the top fixed mounting of box body 131 has lid 132, and the bottom of box body 131 is provided with a plurality of air conditioning slotted holes 134 that are linked together with rectangle slot 3, inserts the back storing box mechanism 13, and cold flow tube mechanism 5 absorbs the heat of keeping cold intracavity portion, and then carries out cold-insulation storage and transportation to the inside bacterin of placing.

Fixed mounting has a plurality of sponge boards 133 between the both sides inner wall of box body 131, and the both sides of sponge board 133 all are provided with a plurality of arc-shaped grooves, when placing the bacterin, with bacterin box disect insertion to between two adjacent sponge boards 133, utilize sponge board 133's elasticity to provide effectual buffering protection to the bacterin, further improve the security in the bacterin transportation.

The bottom fixed mounting of box body 131 has the thermal-insulated diaphragm 135 of a plurality of flexible materials, and thermal-insulated diaphragm 135 staggered distribution in the inside of rectangle slot 3, and thermal-insulated diaphragm 135's setting is when storing box mechanism 13 and taking out, and is isolated to its internal environment, avoids the loss of inside air conditioning, the transfer of the bacterin of being convenient for.

The spout has all been seted up to handle portion 11 bottom and top, and the equal slidable mounting in inside of two spouts has the section to be the handle board 10 of L type structure, the top in cold insulation chamber and bottom inner wall all are provided with from locked groove 9 with handle board 10 looks adaptation, store box mechanism 13 and insert to cold insulation intracavity portion back, the tip of handle board 10 can insert to the inside from locked groove 9, lock storage box mechanism 13, the pine that can appear in the transfer process phenomenon has been avoided, further improve the security of device to bacterin transfer process.

The middle part of the handle part 11 is fixedly provided with a magnetic steel plate 111, one side of the two handle plates 10 close to each other is fixedly provided with a magnetic plate which is mutually repelled with the magnetic steel plate 111, and after the storage box mechanism 13 is inserted, the separation of the handle plates 10 and the self-locking groove 9 is avoided by utilizing the repulsion principle of the magnetic steel plate 111 when no person operates.

The storage battery pack 2 is fixedly installed inside the frame 1, and when the device moves, the storage battery pack 2 can provide electric power support for an electric appliance.

This embodiment is when using, a plurality of relatively independent cold insulation chambeies distribute in the device at cold insulation case 14 both sides, can place its classification in the inside of storing box mechanism 13 at the in-process that the bacterin was transported, inside inserting cold insulation chamber, and then make cold flow pipe mechanism 5 insert to the rectangle slot 3 inside of storing box mechanism 13 bottom, and 3 inner wall extrusion valves 6 of rectangle slot carry out rapid cooling with the cold flow leading-in to cold flow pipe mechanism 5 inside to storing box mechanism 13, every cold insulation chamber mutual independence and mutual noninterference, can not cause the interference to other bacterins at last unloading in-process, the security of the cold-stored transportation in-process of improving the device to the bacterin.

Example 2

Referring to fig. 1-5, in this embodiment, relative to embodiment 1, a limiting protruding rod 121 is fixedly installed on a side surface of a sealing plate 12, and arc-shaped grooves matched with a handle plate 10 are formed in the bottom and the top of the limiting protruding rod 121.

This embodiment is when using, when shrouding 12 closed up, the tip of its spacing nose bar 121 inserted to between two handle boards 10, and then pushes up two handle boards 10 respectively to making it insert more stable, and its tip contradicts at the 111 tip of magnetic steel board, will store the inside of box mechanism 13 firmly fixed at the cold chamber, further improves security and the stability of bacterin transportation in-process.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. A cold storage transfer device for genetic engineering vaccines comprises a rack (1), wherein a cold insulation box (14) is fixedly installed at the top end of the rack (1), two partition plates (7) are fixedly installed inside the cold insulation box (14), a cold air flow channel (4) is arranged between the two partition plates (7), a roller with a foot brake is fixedly installed at the bottom of the rack (1), the cold storage transfer device is characterized in that a refrigeration mechanism (16) is fixedly installed inside the rack (1), an evaporation pipe (15) forming a loop is fixedly installed on the side face of the refrigeration mechanism (16), the end portion of the evaporation pipe (15) extends to the inside of the cold air flow channel (4), a plurality of cold insulation cavities are arranged on two sides of the cold insulation box (14), a storage box mechanism (13) is inserted inside the cold insulation cavities, and a sealing plate (12) is installed on the outer sides of the cold insulation cavities through hinges and hasp locks, the utility model discloses a cold storage box, including cold insulation chamber, cold flow tube mechanism (5), valve (6), cold flow tube mechanism (5), storage box mechanism (13), cold flow tube mechanism (5) and evaporating pipe (15), cold insulation chamber's inside bottom fixed mounting has the cold flow tube mechanism (5) of U type structure, and fixed mounting has between the tip of cold flow tube mechanism (5) and evaporating pipe (15), the inside bottom of storing box mechanism (13) is provided with rectangle slot (3), and cold flow tube mechanism (5) pegs graft in the inside of rectangle slot (3), the tip of storing box mechanism (13) is provided.

2. The refrigerated transport device for the genetically engineered vaccine of claim 1, wherein the refrigeration mechanism (16) comprises a refrigeration compressor, a condenser, a throttle valve and an evaporator, the refrigeration compressor, the condenser, the throttle valve and the evaporator are connected in sequence through pipelines, and the evaporation pipe (15) is installed at the end part of the evaporator.

3. The cold storage transfer device for the genetically engineered vaccine of claim 1, wherein a plurality of cold guide plates (8) are fixedly installed between the top ends of the cold flow pipe mechanisms (5), and a plurality of strip-shaped grooves are formed in the tops of the cold guide plates (8).

4. The cold storage transfer device for the genetically engineered vaccine of claim 1, wherein the storage box mechanism (13) comprises a box body (131), a box cover (132) is fixedly installed at the top end of the box body (131), and a plurality of cold air slot holes (134) communicated with the rectangular slots (3) are formed at the bottom end of the box body (131).

5. The refrigerated transport device for the genetically engineered vaccine of claim 4, wherein a plurality of sponge plates (133) are fixedly installed between the inner walls of the two sides of the box body (131), and a plurality of arc-shaped slots are arranged on both sides of each sponge plate (133).

6. The refrigerated transport device for the genetically engineered vaccine of claim 5, wherein a plurality of heat insulation membranes (135) made of flexible materials are fixedly installed at the bottom of the box body (131), and the heat insulation membranes (135) are distributed in the rectangular slots (3) in a staggered manner.

7. The refrigerated transport device for the genetically engineered vaccine of claim 1, wherein the bottom and the top of the handle part (11) are both provided with sliding grooves, the handle plates (10) with the cross section being L-shaped structures are slidably mounted inside the two sliding grooves, and the inner walls of the top and the bottom of the cold insulation cavity are both provided with self-locking grooves (9) matched with the handle plates (10).

8. The refrigerated transport device for the genetically engineered vaccine of claim 7, wherein the middle part of the handle part (11) is fixedly provided with a magnetic steel plate (111), and one side of the two handle plates (10) close to each other is fixedly provided with a magnetic plate which is mutually exclusive with the magnetic steel plate (111).

9. The refrigerated transport device for genetically engineered vaccines according to claim 1, wherein the storage battery pack (2) is fixedly installed inside the rack (1).

10. The refrigerated transport device for the genetically engineered vaccine of claim 8, characterized in that the side of the closing plate (12) is fixedly installed with a limiting protruding rod (121), and the bottom and the top of the limiting protruding rod (121) are provided with an arc-shaped groove matched with the handle plate (10).