CN112023284A - Focus position real-time monitoring method for focused acoustic dynamic therapy - Google Patents
Focus position real-time monitoring method for focused acoustic dynamic therapy Download PDFInfo
- Publication number
- CN112023284A CN112023284A CN202010905133.9A CN202010905133A CN112023284A CN 112023284 A CN112023284 A CN 112023284A CN 202010905133 A CN202010905133 A CN 202010905133A CN 112023284 A CN112023284 A CN 112023284A
- Authority
- CN
- China
- Prior art keywords
- imaging
- shear wave
- tissue
- acoustic
- target area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/461—Displaying means of special interest
- A61B8/463—Displaying means of special interest characterised by displaying multiple images or images and diagnostic data on one display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Gynecology & Obstetrics (AREA)
- Surgical Instruments (AREA)
Abstract
The invention belongs to the crossing field of biomedicine and acoustics, and particularly relates to a method for generating shear waves which are transmitted in a direction vertical to an acoustic beam by carrying out common mode imaging on a treated target area, starting ultrasonic emission of focused acoustic power treatment and treating the treated target area in the focused acoustic power treatment process, wherein the tissue of the target area is acted by ultrasonic radiation force to generate the shear waves which are transmitted in the direction vertical to the acoustic beam; and then emitting imaging pulses to perform shear wave imaging on the treated target region, and obtaining a sound field intensity distribution diagram in the tissue after fusion, namely judging the focused focal position to complete real-time monitoring. The invention has the beneficial effects that: the invention can directly determine the focus position during focusing acoustic dynamic therapy from the tissue B mode image; the focus position is monitored in real time, so that the accuracy of the acoustic dynamic therapy is improved.
Description
Technical Field
The invention relates to the field of acoustodynamic therapy, in particular to a real-time focal position monitoring method for focusing acoustodynamic therapy.
Technical Field
Currently, the Sonodynamic Therapy (SDT) is a technique that activates a sonosensitizer by ultrasound, and generates active oxygen by using tissue oxygen to exert a biological effect. SDT utilizes the strong penetrability characteristic of ultrasound, can realize noninvasive treatment of deep tissues, and has wide application prospects in the aspects of inhibiting tumor growth and regulating atherosclerosis evolution. When the acoustic dynamic therapy is performed, the focusing mode is adopted to improve the input efficiency of acoustic energy, and the focusing position needs to be monitored in real time to improve the accuracy of the therapy.
The existing sound field focus position monitoring methods comprise a hydrophone method, an optical method, an ultrasonic temperature measurement method and a passive cavitation imaging method. Of these, the hydrophone method and the optical method can obtain the intensity distribution of the sound field, but at present, the method can only be performed in vitro, and thus, the method is not suitable for monitoring the focal position in the tissue. Ultrasound thermometry and passive cavitation are commonly used for high intensity focused ultrasound (hundreds to thousands of W/cm)2) The focus position is monitored during treatment, and the intensity of the emitted sound field is generally 2W/cm during acoustic dynamic treatment2The temperature change generated in the tissue is small, and the cavitation effect is weak, so that the monitoring by an ultrasonic thermometry method and a passive cavitation method is difficult. In contrast, when the focused acoustic power therapy is performed, a strong acoustic radiation force can be generated at a focus so as to excite a shear wave with a larger amplitude, and therefore, the position of the focus can be monitored by performing shear wave imaging on the tissue of a target region (a therapy region) to be treated.
Disclosure of Invention
The present invention is directed to a method for real-time monitoring of the focal position for focused sonodynamic therapy to solve any of the above and other potential problems of the prior art.
In order to solve the technical problems, the technical scheme of the invention is as follows: a real-time focus position monitoring method for focused acoustic dynamic therapy is characterized in that the focus position during focused acoustic dynamic therapy is determined by utilizing an intensity distribution image of an acoustic field in tissue of a treatment target region, so that the real-time focus position monitoring is realized, and the accuracy of the acoustic dynamic therapy is improved.
Further, the normal mode imaging is B mode imaging.
Further, the method comprises the following specific steps:
s1) transmitting imaging pulses by using the phased array probe to carry out common B-mode imaging on a treated target area to obtain a B-mode imaging result;
s2) starting ultrasonic emission of focused acoustic power treatment, treating a treated target area, and generating shear waves which are transmitted in a direction vertical to the direction of the acoustic beam by the action of ultrasonic radiation force on tissues of the target area;
s3) when the therapeutic pulse stops transmitting, transmitting an imaging pulse by using the phased array probe, and carrying out shear wave imaging on a therapeutic target area to obtain a shear wave imaging result;
s4) fusing the shear wave imaging result obtained in S3) with the B mode imaging result obtained in S1) to obtain an intensity distribution image of the sound field in the tissue, obtaining the position of the focus in the tissue according to the image, and monitoring the position of the focus of the acoustic dynamic therapy in real time by repeating the above operations in each pulse repetition period.
Further, in S2), the focused acoustic-dynamic therapeutic ultrasound is to form a focused acoustic field in the tissue, and the generation is geometric focusing, i.e. using an acoustic lens, or electronic focusing, i.e. using a phased array.
Further, in S3), the shear wave imaging pulse and the therapeutic pulse are emitted with a spacing of less than 100 μ S, and the shear wave is spread to both sides by a distance in the order of 1 mm.
Further, the data correlation processing in the shear wave imaging is as follows:
firstly, demodulating the acquired ultrasonic RF signal to obtain an equidirectional component I and an orthogonal component Q thereof;
secondly, substituting the obtained homodromous component I and the orthogonal component Q into the following formula to calculate the amplitude u (n) of the shear wave in the imaging region, wherein the formula is as follows:
in the formula: f. ofcThe center frequency is c, the sound velocity is c, the window length is M, M frame data participate in the correlation calculation, and n + l represent the acquired data frame number.
The tissue includes: skin, fat, muscle, connective tissue and the joints between the tissues.
A focal position real-time monitoring system for focused sonodynamic therapy, the system comprising: an upper computer, a common B-mode imaging device and an ultrasonic device,
the common B-mode imaging device is used for carrying out common B-mode imaging on a treated target area, obtaining a B-mode imaging result and sending the B-mode imaging result to the upper computer;
the ultrasonic device is used for transmitting ultrasonic pulses to a target area to be treated,
and the upper computer is used for processing the received B-mode imaging result and the shear wave imaging result, performing fusion processing to obtain an intensity distribution image of a sound field in the tissue, and obtaining the position of a focus in the tissue according to the image to complete real-time monitoring.
A computer-readable storage medium comprising instructions which, when run on a computer, cause the computer to perform the above-described method for focus position real-time monitoring for focused sonodynamic therapy.
The beneficial effects of the invention are: by adopting the technical scheme, the invention can directly determine the focus position during focusing acoustic dynamic therapy from the tissue B mode image; (2) the focus position is monitored in real time, so that the accuracy of the acoustic dynamic therapy is improved.
Drawings
Fig. 1 is a flow chart of a method for monitoring the focus position of focused acoustodynamic therapy in real time according to the present invention.
Fig. 2 is a schematic diagram of a shear wave imaging method for monitoring the focus position.
Detailed Description
The technical solution of the present invention is further explained with reference to the accompanying drawings and specific embodiments.
The invention relates to a method for monitoring the focus position of focusing acoustic dynamic therapy in real time, which comprises the steps of imaging a treated target region in a common mode in the focusing acoustic dynamic therapy process, then carrying out focusing therapeutic ultrasonic emission, generating shear waves which are transmitted in a direction vertical to an acoustic beam direction under the action of ultrasonic radiation force on the tissue of the treated target region, then emitting imaging pulses to image the shear waves in the treated target region, obtaining an intensity distribution diagram of an acoustic field in the tissue after fusion, judging the focused focus position, and completing real-time monitoring.
The normal mode imaging is B mode imaging.
As shown in fig. 1, the method comprises the following specific steps:
s1) utilizing the phased array probe to transmit imaging pulses to carry out common B-mode imaging on the treatment area, and obtaining a B-mode imaging result;
s2) starting ultrasonic emission of focused acoustic power treatment, treating a treated target area, and generating shear waves which are transmitted in a direction vertical to the direction of the acoustic beam by the action of ultrasonic radiation force on tissues of the target area;
s3) when the transmission of the treatment pulse is stopped, transmitting an imaging pulse by using the phased array probe, and carrying out shear wave imaging on the treatment area to obtain a shear wave imaging result;
s4) fusing the shear wave imaging result obtained in S3) with the B mode imaging result obtained in S1) to obtain an intensity distribution image of the sound field in the tissue, obtaining the position of the focus in the tissue according to the image, and monitoring the position of the focus of the acoustic dynamic therapy in real time by repeating the above operations in each pulse repetition period.
The sonodynamic therapeutic ultrasound in S2) is to form a focused sound field in the tissue, and the generation method is geometric focusing, that is, using an acoustic lens, or electronic focusing, that is, using a phased array method.
Said S3), the shear wave imaging pulse is emitted less than 100 μ S apart from the treatment pulse, and the shear wave is spread to both sides by a distance on the order of 1 mm.
The data correlation processing in shear wave imaging is as follows:
firstly, demodulating the acquired ultrasonic RF signal to obtain an equidirectional component I and an orthogonal component Q thereof;
secondly, substituting the obtained homodromous component I and the orthogonal component Q into the following formula to calculate the amplitude u (n) of the shear wave in the imaging region, wherein the formula is as follows:
in the formula: f. ofcThe center frequency is c, the sound velocity is c, the window length is M, M frame data participate in the correlation calculation, and n + l represent the acquired data frame number.
The tissue includes: skin, fat, muscle, connective tissue and the joints between the tissues.
A focal position real-time monitoring system for focused sonodynamic therapy, the system comprising: an upper computer, a common B-mode imaging device and an ultrasonic device,
the common B-mode imaging device is used for carrying out common B-mode imaging on a treated target area, obtaining a B-mode imaging result and sending the B-mode imaging result to the upper computer;
the ultrasonic device is used for transmitting ultrasonic pulses to a target area to be treated,
and the upper computer is used for processing the received B-mode imaging result and the shear wave imaging result, performing fusion processing to obtain an intensity distribution image of a sound field in the tissue, and obtaining the position of a focus in the tissue according to the image to complete real-time monitoring.
A computer-readable storage medium comprising instructions which, when run on a computer, cause the computer to perform the above-described method for focus position real-time monitoring for focused sonodynamic therapy.
Since the shear wave is generated and then rapidly propagates to both sides, its velocity is about m/s. In the scheme, in order to ensure the monitoring effect as much as possible, the focal position is displayed by only adopting the first three frames of the shear wave imaging result, and the diffusion distance of the shear wave to the two sides is in the order of 1mm in the time, so that the monitoring requirement can be met.
In general, information such as tissue mechanical property distribution is desired in conventional shear imaging, and therefore information about propagation velocity of shear waves in different regions of a tissue needs to be acquired. Unlike conventional shear imaging, the focus position of focused therapeutic ultrasound in tissue is of interest in the present technique. After the tissue is subjected to the ultrasonic pulses, transverse vibrations (shear waves) are generated and propagate in a direction perpendicular to the excitation ultrasound. The stronger the ultrasonic field intensity is, the larger the acting force applied to the tissue is, the higher the amplitude of the generated shear wave is, and therefore, the amplitude of the shear wave generated at the focus is the largest. However, once the shear wave is generated, the shear wave propagates to both sides and the amplitude rapidly attenuates, and if the imaging time is too long, only the distribution of the shear wave far away from the generation region can be obtained, and the amplitude cannot represent the intensity of the excitation ultrasound in the tissue due to the tissue attenuation, so that the focal position is difficult to obtain. In addition, if the excitation ultrasound starts to emit imaging pulses and acquire imaging data immediately after stopping, due to the large amplitude and long attenuation time of the excitation ultrasound, reflected echoes of the excitation ultrasound are likely to cause interference on imaging, even cause imaging failure, and the focal position cannot be obtained. Therefore, after the ultrasonic excitation is stopped, a period of time t is required to be set, then, the imaging pulse is started to be transmitted, and the initial n frames of data are taken for shear wave imaging, so that the intensity distribution of the sound field in the tissue can be obtained, and the focal position can be judged. At this time, the focus position monitoring accuracy is v (t + nf), where v is the shear wave velocity and f is the shear wave imaging frame rate.
According to the actual measurement experience, when the focusing depth is about 30mm, the interval time t is generally 100-150 mu s, and then the interference of exciting the strong ultrasonic echo can be eliminated. Because the propagation velocity of the shear wave is generally in the order of m/s, when the number of imaging frames is 1 ten thousand frames per second, if the first 4 frames are taken for processing, the monitoring precision of the focal position is about 1 mm.
Example (b):
the experiment is carried out on a phantom with the elastic modulus of 12.5kPa by adopting a Verasonics Vantage256 channel ultrasonic system, the transducer is a Carry L9-4 linear array 128-element medical probe, wherein the middle 32 elements are used for exciting focused sound waves to generate sound radiation force, the focusing depth is about 15mm, and the exciting voltage is 20V. And after the focused sound wave is transmitted, observing the generation position of the shear wave by adopting plane wave ultrafast imaging, and setting the frame rate to 10000 frames/s.
The left side of fig. 2 is a B-mode image with top area 1 representing the 32 element positions for exciting acoustic radiation force, white box 2 being the area to be monitored for shear waves using ultra-fast imaging, and blank box 3 being marked as the predetermined focus position. The right side is a monitoring result, and the blue area 4 is a shear wave imaging graph and corresponds to the white frame 2 in the left graph; the middle yellow area 5 represents the area where the intensity of the shear wave is high, i.e. the focal point area, and the position of the area is found to be substantially coincident with the position of the focal point area 3 in the left figure, i.e. the focal point position can be monitored by using the method.
In the acoustic dynamic treatment process, the tissue is acted by the ultrasonic radiation force to generate shear waves which are transmitted in the direction vertical to the direction of the acoustic beam, and for focused ultrasound, the sound field at the focus is strongest, the acoustic radiation force is the largest, and therefore the corresponding shear wave amplitude is the highest. Therefore, the position of the focus can be obtained from the image by performing shear wave imaging on the treated target area. The position of the focal point in the tissue during the sonodynamic treatment can thus be monitored in real time.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. A real-time monitoring method for the focus position of focused acoustic dynamic therapy is characterized in that common imaging and shear wave imaging are carried out on tissues of a treatment target area, an intensity distribution image of an acoustic field in the tissues of the treatment target area is obtained after fusion, the focus position during focused acoustic dynamic therapy is analyzed and determined, and real-time monitoring of the focus position is realized.
2. The method of claim 1, wherein the normal mode imaging is B-mode imaging.
3. The method according to claim 2, characterized in that the method comprises the following specific steps:
s1) transmitting imaging pulses by using the phased array probe to carry out common B-mode imaging on a treated target area to obtain a B-mode imaging result;
s2) starting ultrasonic emission of focused acoustic power treatment, treating a treated target area, and generating shear waves which are transmitted in a direction vertical to the direction of the acoustic beam by the action of ultrasonic radiation force on tissues of the target area;
s3) when the therapeutic pulse stops transmitting, setting time at intervals, transmitting an imaging pulse by using a phased array probe, and carrying out shear wave imaging on a therapeutic target area to obtain a shear wave imaging result;
s4) fusing the shear wave imaging result obtained in S3) with the B mode imaging result obtained in S1) to obtain an intensity distribution image of the sound field in the tissue, obtaining the position of the focus in the tissue according to the image, and monitoring the position of the focus of the acoustic dynamic therapy in real time by repeating the above operations in each pulse repetition period.
4. The method as claimed in claim 3, wherein the focused sonodynamic therapeutic ultrasound in S2) is a focused acoustic field generated in tissue by geometric focusing using acoustic lenses or by electronic focusing using phased array.
5. The method according to claim 3, wherein in S3), the shear wave imaging pulse is emitted less than 100 μ S apart from the treatment pulse, and the shear wave dispersion distance to both sides is in the order of 1 mm.
6. The method according to claim 3, wherein the image processing in the shear wave imaging comprises the following specific steps:
firstly, demodulating the acquired ultrasonic RF signal to obtain an equidirectional component I and an orthogonal component Q thereof;
then, substituting the obtained homodromous component I and the orthogonal component Q into the following formula to calculate the amplitude u (n) of the shear wave in the imaging region, wherein the formula is as follows:
in the formula: f. ofcThe center frequency is c, the sound velocity is c, the window length is M, M frames of data participate in correlation calculation, and n + l represent the sequence number of the acquired data frames.
7. The method of claim 1, wherein the organizing comprises: skin, fat, muscle, connective tissue and the joints between the tissues.
8. A focal position real-time monitoring system for focused sonodynamic therapy, the system comprising: an upper computer, a common B-mode imaging device and an ultrasonic device,
the common B-mode imaging device is used for carrying out common B-mode imaging on a treated target area, obtaining a B-mode imaging result and sending the B-mode imaging result to the upper computer;
the ultrasonic device is used for transmitting ultrasonic pulses to a target area to be treated,
and the upper computer is used for processing the received B-mode imaging result and the shear wave imaging result, performing fusion processing to obtain an intensity distribution image of a sound field in the tissue, and obtaining the position of a focus in the tissue according to the image to complete real-time monitoring.
9. A computer-readable storage medium comprising instructions which, when run on a computer, cause the computer to perform the method for real-time monitoring of focus position for focused sonodynamic therapy as claimed in any one of claims 1-7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010905133.9A CN112023284A (en) | 2020-09-01 | 2020-09-01 | Focus position real-time monitoring method for focused acoustic dynamic therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010905133.9A CN112023284A (en) | 2020-09-01 | 2020-09-01 | Focus position real-time monitoring method for focused acoustic dynamic therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112023284A true CN112023284A (en) | 2020-12-04 |
Family
ID=73590880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010905133.9A Pending CN112023284A (en) | 2020-09-01 | 2020-09-01 | Focus position real-time monitoring method for focused acoustic dynamic therapy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112023284A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114904171A (en) * | 2021-02-07 | 2022-08-16 | 重庆海扶医疗科技股份有限公司 | Ultrasonic ablation system and control method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690677A (en) * | 2009-10-13 | 2010-04-07 | 西安交通大学 | Focused ultrosound therapy combined array element phased array and multifocal shear wave imaging system |
| CN101902971A (en) * | 2007-12-21 | 2010-12-01 | 皇家飞利浦电子股份有限公司 | Systems and methods for tracking and guiding high intensity focused ultrasound beams |
| CN104856731A (en) * | 2009-10-12 | 2015-08-26 | 科纳医药股份有限公司 | Energy modulation of nerves |
| CN107261344A (en) * | 2017-06-29 | 2017-10-20 | 哈尔滨医科大学 | A kind of ultrasonic adapted local cosine transform method for sound dynamic therapy |
| US20190000422A1 (en) * | 2017-06-30 | 2019-01-03 | Butterfly Network, Inc. | Elasticity imaging in high intensity focused ultrasound |
| CN111343925A (en) * | 2017-10-12 | 2020-06-26 | 皇家飞利浦有限公司 | Ultrasound shear wave imaging with patient-adaptive shear wave generation |
-
2020
- 2020-09-01 CN CN202010905133.9A patent/CN112023284A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101902971A (en) * | 2007-12-21 | 2010-12-01 | 皇家飞利浦电子股份有限公司 | Systems and methods for tracking and guiding high intensity focused ultrasound beams |
| CN104856731A (en) * | 2009-10-12 | 2015-08-26 | 科纳医药股份有限公司 | Energy modulation of nerves |
| CN101690677A (en) * | 2009-10-13 | 2010-04-07 | 西安交通大学 | Focused ultrosound therapy combined array element phased array and multifocal shear wave imaging system |
| CN107261344A (en) * | 2017-06-29 | 2017-10-20 | 哈尔滨医科大学 | A kind of ultrasonic adapted local cosine transform method for sound dynamic therapy |
| US20190000422A1 (en) * | 2017-06-30 | 2019-01-03 | Butterfly Network, Inc. | Elasticity imaging in high intensity focused ultrasound |
| CN111343925A (en) * | 2017-10-12 | 2020-06-26 | 皇家飞利浦有限公司 | Ultrasound shear wave imaging with patient-adaptive shear wave generation |
Non-Patent Citations (4)
| Title |
|---|
| 喻红霞 等: "《新编临床超声诊断》", 31 March 2019 * |
| 崔少国: "《超声弹性成像的理论、方法与关键技术》", 31 December 2013 * |
| 林浩铭: "《基于声辐力的超声弹性成像关键技术及对肝纤维化评估的初步研究》", 《中国博士学位论文全文数据库》 * |
| 潘雪婷: "《金属有机框架衍生的碳纳米结构用于声动力癌症治疗》", 《中国优秀硕士学位论文全文数据库》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114904171A (en) * | 2021-02-07 | 2022-08-16 | 重庆海扶医疗科技股份有限公司 | Ultrasonic ablation system and control method thereof |
| CN114904171B (en) * | 2021-02-07 | 2024-01-26 | 重庆海扶医疗科技股份有限公司 | Ultrasonic ablation system and control method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11717270B2 (en) | Method, apparatus and system for imaging in ultrasonic scanning | |
| US7587291B1 (en) | Focusing of broadband acoustic signals using time-reversed acoustics | |
| US20150258352A1 (en) | Frequency compounding ultrasound pulses for imaging and therapy | |
| CN109730722B (en) | Elastic imaging method based on focused ultrasonic acoustic vibration signal | |
| CN109745077B (en) | Elastic characteristic detection method based on focused ultrasonic sound vibration signal | |
| US8535229B2 (en) | Ultrasonographic device | |
| US20150374342A1 (en) | Method for focal point compensation, and ultrasonic medical apparatus therefor | |
| CN1809399A (en) | Shear mode therapeutic ultrasound | |
| CN110507918A (en) | A kind of ultrasonic acupuncture and moxibustion system and ultrasonic acupuncture and moxibustion system control method | |
| CN112349446A (en) | Control method and acoustic tweezers device | |
| Karzova et al. | Shock formation and nonlinear saturation effects in the ultrasound field of a diagnostic curvilinear probe | |
| CN112023284A (en) | Focus position real-time monitoring method for focused acoustic dynamic therapy | |
| US8668658B2 (en) | Derating method for therapeutic applications of high intensity focused ultrasound | |
| CN109381806B (en) | Ultrasonic imaging system and method and ultrasonic treatment system | |
| CN210447159U (en) | Vibration puncture device and ultrasonic imaging system | |
| KR20180135892A (en) | Method, system and computer program product for reinforced shear wave ultrasound imaging | |
| JP6552724B2 (en) | Ultrasonic diagnostic apparatus and control method of ultrasonic diagnostic apparatus | |
| Ramalli et al. | Safety of fast cardiac imaging using multiple transmit beams: Experimental verification | |
| CN113117265B (en) | Detection device | |
| KR20160022639A (en) | Ultrasonic diagnostic equipment capable of generating harmonic image and method of generating ultrasonic image including harmonic image | |
| Kang et al. | Transmission efficiency comparison between dual-mode conversion incidence and normal incidence | |
| CN113117268B (en) | Device for detecting cavitation effect and ultrasonic treatment equipment | |
| Karaböce et al. | Investigation of ultrasonic fields produced by HIFU transducers used in cancer therapy | |
| US20230324530A1 (en) | Ultrasound imaging methods | |
| US20220128517A1 (en) | Focal Point Determination Based on Nonlinear Mixing of Sound Beams |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201204 |
|
| RJ01 | Rejection of invention patent application after publication |