CN112022461A

CN112022461A - Be applied to intravascular stent of carotid

Info

Publication number: CN112022461A
Application number: CN202010976796.XA
Authority: CN
Inventors: 杨耀国
Original assignee: Beijing Meidi Micro Technology Co ltd
Current assignee: Beijing Meidi Micro Technology Co ltd
Priority date: 2020-09-16
Filing date: 2020-09-16
Publication date: 2020-12-04
Anticipated expiration: 2040-09-16
Also published as: CN112022461B

Abstract

A blood vessel stent applied to carotid artery comprises a tubular stent body formed by butting a common carotid artery stent section and an internal carotid artery stent section; the internal carotid artery stent section is a first conical structure which is matched with the shape of a human internal carotid artery blood vessel and extends upwards in an axial conical manner, and the area of the cross section of the upper end of the first conical structure is smaller than that of the cross section of the lower end of the first conical structure; the common carotid artery stent section is arranged into a second conical structure or a straight cylindrical structure which is matched with the common carotid artery blood vessel of a human body and extends upwards in an axial taper manner, the upper end of the second conical structure is consistent with the lower end of the first conical structure in size, the slopes of the second conical structure and the first conical structure are consistent, and the upper end of the straight cylindrical structure is consistent with the lower end of the first conical structure in size; the tubular stent body comprises an inner stent and/or an outer stent; a first mesh structure and a second mesh structure are respectively arranged on the surfaces of the inner layer support and the outer layer support, and an overlapping area exists between the first mesh structure and the second mesh structure.

Description

Be applied to intravascular stent of carotid

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a vascular stent applied to carotid artery.

Background

The carotid artery is a large blood vessel that transports blood from the heart to the head, face, and neck, and is one of the main blood supply vessels of the brain, whereas carotid stenosis is the major risk factor and etiological basis for ischemic cerebrovascular disease, and 25% of ischemic stroke is associated with carotid stenosis or occlusion.

Carotid stenosis is a common disease, including congenital and acquired pathological changes, which seriously affects blood supply flow and causes insufficient blood and oxygen supply for the whole body. At present, the main therapeutic methods for Carotid stenosis are medical drug therapy, Carotid Endarterectomy (CEA), and Carotid stenting (CAS). In recent 20 years, with the aging of neuroimaging and neurointervention techniques, the improvement of intervention materials and the improvement of operator techniques, carotid artery stent implantation has become a main treatment method for carotid artery stenosis due to the characteristics of safety, effectiveness, minimal invasion, remarkable treatment effect and the like.

Carotid stenting is the procedure of placing a stent in a carotid artery to maintain the vessel in an expanded state of the original vessel diameter. The blood vessel support is a small tubular object integrally formed by an annular metal net, and the placement mode is that a balloon catheter is guided to an affected part, a narrow part is opened by utilizing the expansion of the balloon, and then the blood vessel support is kept and fixed at the narrow part and then the balloon is taken out; after the vascular stent is implanted, the blood vessel can keep the expansion state of the original pipe diameter, and the blood circulation of the blood vessel is well maintained, so that the symptoms of cerebrovascular diseases are effectively reduced. And once placed in the blood vessel, the blood vessel stent is covered by the new blood vessel intima, is not exposed in the blood vessel and is permanently left in the body of the patient.

In medical clinical application, the vascular stent can realize the purpose of expanding the blood vessel and effectively improving the occurrence of vascular restenosis, but clinical results have certain difference due to the difference of stent mesh area, unit structure design and radial supporting force of different stents. The stent mesh area of the blood vessel stent has certain influence on the free area in the carotid artery, and the free area is closely related to the curative effect of the carotid artery stent implantation; the unit structure design comprises an open-loop design mode and a closed-loop design mode, the open-loop stent is more adaptive to the anatomical structure of the blood vessel, but the range of target lesion coverage is smaller, and the closed-loop stent can cover a plaque with a larger range, but the compliance is reduced and the possibility of poor adherence is increased; and if the unit structure is unreasonable in design, the risk of hanging the umbrella is directly increased; in addition, the ideal blood vessel stent should have low radial supporting force and high anti-vessel retraction capability, while the existing nickel titanium stents all have high radial supporting force, which can generate continuous pressure on the carotid sinus, and the direct result is that the hypotension of the patient is caused, thereby increasing the risk of subsequent treatment; therefore, a blood vessel stent which covers the lesion part to the maximum extent, has reasonable unit structure design and can be well attached to the inner wall of a blood vessel is needed, so that the postoperative risk of carotid artery stent implantation is effectively reduced.

The invention aims to solve the problems of mesh area, unit structure design and radial supporting force of the existing intravascular stent, and designs the intravascular stent applied to the carotid artery stent, wherein the stent covers a focus part to the maximum extent by reducing the mesh area, so that stroke is effectively prevented; the design of combining the open-loop stent and the closed-loop stent ensures that the stent has higher flexibility and can cover wider plaques, and the risk of hanging the umbrella is reduced to the greatest extent by smoothing the inner surface of the stent; meanwhile, in order to reduce the occurrence rate of adverse events such as hypotension, the radial supporting force is further optimized, and the integrity of the lumen is maintained.

Disclosure of Invention

In order to overcome the problems that the mesh area of the blood vessel stent in the prior art can not cover the lesion part to the maximum extent, the design of a unit structure has clinical risks, and the radial supporting force and the anti-vessel retraction capability are still required to be further optimized, the invention provides the blood vessel stent applied to the carotid artery.

A blood vessel stent applied to carotid artery comprises a tubular stent body formed by butting a common carotid artery stent section and an internal carotid artery stent section; the internal carotid artery stent section is a first conical structure which is matched with the shape of a human internal carotid artery blood vessel and extends upwards in an axial conical manner, and the area of the cross section of the upper end of the first conical structure is smaller than that of the cross section of the lower end of the first conical structure; the common carotid artery stent section is of a second conical structure or a straight cylindrical structure which is matched with the common carotid artery blood vessel of a human body and extends upwards in an axial conical manner, the upper end of the second conical structure is consistent with the lower end of the first conical structure in size, the slopes of the second conical structure and the first conical structure are consistent, and the upper end of the straight cylindrical structure is consistent with the lower end of the first conical structure in size; the tubular stent body comprises an inner stent and/or an outer stent, the inner stent is made of a metal material with good biocompatibility, and the outer stent is made of a metal or non-metal material; the utility model discloses a blood flow support, including inlayer support, outer support, first mesh structure, second mesh structure, the first mesh structure that runs through the inlayer support sets up on inlayer support surface the second mesh structure that runs through outer support sets up on outer support surface, and first mesh structure and second mesh structure exist the overlap region of guaranteeing the unobstructed nature of blood flow. Through setting up the identical tubulose stake body with human blood vessel shape to through setting up the first mesh structure on the inlayer support to and the second mesh structure on the outer support design of distinguishing, guaranteed effectively that each branch's blood flow is unblocked and stable after putting into this support affected part, reduce the incidence of postoperative risk.

Further, the area of the first mesh structure is smaller than that of the second mesh structure, and the area of the first mesh structure is set to be 0.02-20mm²The area of the second mesh structure is set to be 1-30mm²。

Further, the first mesh structure comprises open meshes positioned at the upper end of the internal carotid artery stent section and the lower end of the common carotid artery stent section, and closed meshes positioned between the open meshes at the two ends; the design of the open loop at the two ends and the closed loop in the middle combines the advantages of the design of the open loop stent and the closed loop stent, the flexibility is higher so as to adapt to the complicated anatomical structure of the carotid artery, and meanwhile, wider plaques can be covered.

Furthermore, the open type meshes consist of a plurality of first sine wave-shaped support rings which are distributed along the axial direction and have good expansion performance, so that the stent can be completely expanded to be tightly attached to the inner wall of the blood vessel; the upper layer and the lower layer of the first sine wave-shaped support ring are connected through a first connecting piece, and only one first connecting piece is arranged between the adjacent upper layer and the lower layer; and two adjacent first connecting pieces are arranged at an interval of 1.5-4.5 weeks, the upper ends of the first connecting pieces are connected with the upper layer first sine wave-shaped support ring, and the lower ends of the first connecting pieces are connected with the lower layer first sine wave-shaped support ring.

Preferably, two adjacent first connectors are arranged at intervals of 2.5 weeks, wherein a1 and a2, b1 and b2, and c1 and c2 are connecting points which are sequentially connected; and the connecting lines of the midpoints of the first connecting pieces at a1 and a2, b1 and b2, and c1 and c2 are in a spiral shape. This kind of setting can effectively guarantee this support to have fine compliance.

Further, in any adjacent upper and lower first sinusoidal waveform support rings, all the peaks or troughs of the upper first sinusoidal waveform support ring are axially aligned with all the peaks or troughs of the lower first sinusoidal waveform support ring.

Or in the adjacent upper layer and lower layer first sine wave-shaped support rings, included angles between the axial connecting lines of all wave crests or wave troughs of the upper layer first sine wave-shaped support ring and all wave crests or wave troughs of the lower layer first sine wave-shaped support ring and the vertical direction are set to be 30-45 degrees, namely the first sine wave-shaped support ring is set to be a spiral shape capable of adapting to the twisted shape of the blood vessel.

Furthermore, the corners of the first sine wave-shaped support ring are all rounded corners.

Further, the angle between the wave crest and the wave trough of the first sine wave-shaped support ring is alpha, and the range of the alpha is set to be 45-90 degrees.

Furthermore, the closed type meshes are closed hollow meshes consisting of a plurality of rhombic support rings distributed along the axial direction; the angle of the first diagonal of the diamond-shaped support ring is 30-120 degrees, and the angle of the second diagonal is 150-60 degrees. The closed mesh structure design can ensure that the stent can cover plaques in a wider range, and the plaque falling-off capability is effectively prevented.

Or the closed type meshes are closed hollowed-out meshes consisting of a plurality of second sine wave-shaped support rings which are distributed along the axial direction and are not intersected with each other at two adjacent layers, and second connecting pieces positioned between the adjacent upper layer second sine wave-shaped support rings and the adjacent lower layer second sine wave-shaped support rings; and a second connecting piece is arranged between the adjacent upper-layer and lower-layer second sine wave-shaped supporting rings and connected with each other, and the second connecting piece is arranged at intervals of 1 week.

Or the closed type meshes are closed hollow meshes consisting of a plurality of second sine wave-shaped support rings which are distributed along the axial direction and have cross points at two adjacent layers; all wave crests or wave troughs of the upper-layer second sine wave-shaped support ring are axially aligned with all wave crests or wave troughs of the lower-layer second sine wave-shaped support ring, the wave troughs of the adjacent upper-layer second sine wave-shaped support ring are overlapped with the wave crests of the lower-layer second sine wave-shaped support ring, and the overlapped area is in a diamond shape.

Or the closed type meshes are composed of a plurality of oval support rings which are distributed along the axial direction and have strong radial bearing capacity, adjacent oval support rings which are distributed along the radial direction are connected through a second connecting piece, and the edges of adjacent oval support rings which are distributed along the axial direction are integrally connected or connected through a third connecting piece.

Further, every 1 adjacent circle of the first sine wave-shaped support ring interval comprises 2 oval support rings, and the wave crests or wave troughs of the first sine wave-shaped support rings are connected with the edges of the oval support rings positioned in the middle through first connecting pieces, wherein d1 and d2, and e1 and e2 are sequentially connected as connecting points.

Or the closed type meshes consist of a plurality of arch support rings which are distributed along the axial direction and have strong retraction resistance; the arched support rings comprise a first arched support ring at the upper end and a second arched support ring at the lower end, and the lower end of the first arched support ring is fixedly connected with the port at the upper end of the second arched support ring. In addition, adjacent arch-shaped support rings which are distributed in the radial direction are connected through a second connecting piece, and adjacent arch-shaped support rings which are distributed in the axial direction are connected through a third connecting piece.

Furthermore, every 1 adjacent circle of the first sine wave-shaped support ring interval comprises 1 arch-shaped support ring, the wave crest or the wave trough of the first sine wave-shaped support ring is connected with the edge of the arch-shaped support ring through a first connecting piece, wherein f1 and f2 are connecting points and are connected in sequence.

Furthermore, the central angle reading of the first arched support ring is 120 degrees, and the area of a closed graph formed by connecting lines of the arc length and the two ends of the arc length of the first arched support ring is 0.01-10mm²(ii) a The second arched support ring conforms to the dimensional definition of the first arched support ring.

Further, the first and second and third links are arranged in a straight line type or an S-type or an omega-type, and the length of the second link is 1/4-1/2, preferably 1/3, of the first link.

Further, the second mesh structure on the outer layer support is a diamond mesh structure so as to adapt to clinical use requirements.

Further, the first mesh structure density of the internal carotid artery stent section on the inner stent is greater than the first mesh structure density of the stent section located in the common carotid artery; in a single rhombic mesh structure of the second mesh structure, the number of first meshes positioned in the internal carotid artery stent section is 10-100, and the number of first meshes positioned in the common carotid artery stent section is 8-50; the arrangement can effectively ensure that the blood flow passing rate at the position of the common carotid artery is greater than that at the position of the internal carotid artery.

Further, the first mesh structure area of the internal carotid artery stent section on the inner stent is smaller than the first mesh structure area of the common carotid artery stent section; the area of the first mesh structure positioned on the internal carotid artery stent section is set to be 0.02-6mm²The area of the first mesh structure positioned on the common carotid artery stent section is set to be 1-20mm². The mesh area ensures smoothness of blood flow to the maximum extent and effectively prevents stroke.

Further, the outer layer stent is made of a self-expanding nickel-titanium alloy layer or a cobalt-chromium alloy layer and polyester resin or polyester resin (PET) or expanded polytetrafluoroethylene (e-PTFE) material.

Further, a film covering structure which is completely covered, partially covered or not covered is arranged on the outer-layer stent, and the film covering structure is made of terylene or polytetrafluoroethylene and used for ensuring the smoothness of blood flow in the external carotid artery.

Furthermore, a film covering structure is arranged in the area where the closed type meshes are located, and a non-covering structure is arranged in the area where the open type meshes are located.

Further, a drug coating capable of effectively diluting blood or inhibiting intimal hyperplasia is arranged on the inner surface and/or the outer surface of the inner stent and the inner surface and/or the outer surface of the outer stent; wherein the blood diluting medicine coating is heparin and other blood diluting medicines, and the intimal hyperplasia inhibiting medicine coating is paclitaxel, rapamycin and other medicines.

Further, the length range of the internal carotid artery stent section is 5-16 mm; the length range of the common carotid artery stent section is 6-15 mm.

Preferably, the length of the internal carotid artery stent section ranges from 8 mm to 10 mm; the length range of the common carotid artery stent section is 8-10mm, and the length setting can effectively ensure the distraction effect on the narrow carotid artery.

Further, the diameter range of the internal carotid artery stent section is 5-6 mm; the minimum diameter of the common carotid artery stent section is not less than the diameter of the internal carotid artery stent section, and the maximum diameter is less than 10 mm; the device can meet the operation requirements of internal carotid artery and common carotid artery of most patients.

Compared with the prior art, the intravascular stent has a conical structure which is integrally matched with the carotid artery of a human body, or a double-layer tubular stent body with a straight-tube-shaped common carotid artery part and a conical internal carotid artery part, and the area size and the density of the first mesh structure on the inner-layer stent are limited, so that the clinical use requirement is met to the greatest extent. In the technical scheme, the narrow artery part is mainly supported by closed meshes, and the two ends of the narrow artery are supported by first sine wave-shaped support rings with better expansibility, so that the stent can be completely expanded to be tightly attached to the inner wall of a blood vessel. In addition, this technical scheme is through the setting that selectively increases tectorial membrane structure and medicine coating on this blood vessel support, plays certain effect to preventing the blood vessel restenosis.

Drawings

FIG. 1 is a schematic view of the overall structure of the overall conical structure of the present invention;

FIG. 2 is a schematic view of the overall structure of the inner stent of the present invention, which has an overall tapered structure;

FIG. 3 is the whole structure diagram of the inner layer stent with the common carotid artery stent section in a straight cylinder shape and the internal carotid artery stent section in a conical structure according to the invention;

FIG. 4 is a schematic view of the overall structure of the outer stent of the present invention having an overall tapered structure;

FIG. 5 is a partial enlarged structural view of an inner layer support of the first sinusoidal support ring according to the present invention;

FIG. 6 is a partially enlarged structural view of an inner layer stent at the joint between a first sine wave shaped support ring and a diamond shaped support ring according to the present invention;

FIG. 7 is a partially enlarged structural view of the inner and outer layers of the first sinusoidal support ring of the present invention at the junction with the diamond support ring;

FIG. 8 is an enlarged partial view of the inner stent of a second (non-intersecting) sinusoidal support ring of the present invention;

FIG. 9 is a partial enlarged structural view of the inner stent at the junction between a first sinusoidal waveform support ring and a second sinusoidal waveform support ring (where there are crossover points) in accordance with the present invention;

FIG. 10 is an enlarged partial view of the inner stent at the connection between the first sinusoidal support ring and the elliptical support ring of the present invention;

FIG. 11 is a partial enlarged view of the inner support of the oval support ring of the present invention;

FIG. 12 is an enlarged partial schematic view of the inner layer of the stent at the junction between the first sinusoidal support ring and the arch support ring of the present invention;

FIG. 13 is an enlarged partial view of the inner layer of the arch support ring of the present invention;

in the figure, 1, a common carotid artery stent section; 2. an internal carotid artery stent section; 3. an inner layer support; 4. an outer layer bracket; 5. a first sinusoidal waveform support ring; 6. a first connecting member; 71. a diamond-shaped support ring; 72. a second sinusoidal waveform support ring; 73. an elliptical support ring; 74. an arch support ring; 75. a second connecting member; 76. and a third connecting member.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below by specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and other advantages and effects of the present invention can be easily understood by those skilled in the art from the disclosure of the present specification. The present invention can be implemented or applied by other different specific embodiments, and the features in the following embodiments and embodiments can be combined with each other without conflict, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.

EXAMPLE 1 vascular Stent for application to the carotid artery

A blood vessel stent applied to carotid artery comprises a tubular stent body formed by butting a common carotid artery stent section 1 and an internal carotid artery stent section 2; the internal carotid artery stent section 2 is a first conical structure which is matched with the shape of a human internal carotid artery blood vessel and extends upwards in an axial conical manner, and the area of the cross section of the upper end of the first conical structure is smaller than that of the cross section of the lower end of the first conical structure; the common carotid artery stent section 1 is arranged into a second conical structure or a straight cylindrical structure which is matched with the common carotid artery blood vessel of a human body and extends upwards in an axial taper manner, the upper end of the second conical structure is consistent with the lower end of the first conical structure in size, the slopes of the second conical structure and the first conical structure are consistent, and the upper end of the straight cylindrical structure is consistent with the lower end of the first conical structure in size; the tubular stent body comprises an inner stent 3 and/or an outer stent 4, the inner stent 3 is made of a metal material with good biocompatibility, and the outer stent 4 is made of a metal or non-metal material; the surface of the inner layer support 3 is provided with a first mesh structure which runs through the inner layer support 3, the surface of the outer layer support 4 is provided with a second mesh structure which runs through the outer layer support 4, and the first mesh structure and the second mesh structure have an overlapping area which guarantees the smoothness of blood flow. Through setting up the identical tubulose stake body with human blood vessel shape to through distinguishing the design to the first mesh structure of setting on inlayer support 3 to and the second mesh structure on outer support 4, guaranteed effectively that each branch's blood flow is unblocked and stable after putting into this support affected part, reduce the incidence of postoperative risk.

The area of the first mesh structure is smaller than that of the second meshThe area of the pore structure and the area of the first mesh structure are set to be 0.02-20mm²The area of the second mesh structure is set to be 1-30mm²。

The first mesh structure comprises open meshes positioned at the upper end of the internal carotid artery stent section 2 and the lower end of the common carotid artery stent section 1, and closed meshes positioned between the open meshes at the two ends; the design of the open loop at the two ends and the closed loop in the middle combines the advantages of the design of the open loop stent and the closed loop stent, the flexibility is higher so as to adapt to the complicated anatomical structure of the carotid artery, and meanwhile, wider plaques can be covered.

The open type meshes are composed of a plurality of first sine wave-shaped support rings 5 which are distributed along the axial direction and have good expansion performance, so that the stent can be completely expanded to be tightly attached to the inner wall of a blood vessel; the upper layer and the lower layer of the first sine wave-shaped support ring 5 are connected through a first connecting piece 6, and only one first connecting piece 6 is arranged between the adjacent upper layer and the lower layer; and two adjacent first connecting pieces 6 are arranged at an interval of 1.5-4.5 weeks, the upper ends of the first connecting pieces 6 are connected with the upper layer first sine wave-shaped support ring 5, and the lower ends of the first connecting pieces 6 are connected with the lower layer first sine wave-shaped support ring 5.

Two adjacent first connecting pieces 6 are arranged at intervals of 2.5 weeks, wherein a1 and a2, b1 and b2, and c1 and c2 are connecting points which are sequentially connected; and the midpoints of the first connecting pieces 6 at a1 and a2, b1 and b2, and c1 and c2 form a spiral shape. This kind of setting can effectively guarantee this support to have fine compliance.

In any adjacent upper and lower first sinusoidal waveform support rings 5, all the peaks or troughs of the upper first sinusoidal waveform support ring 5 are axially aligned with all the peaks or troughs of the lower first sinusoidal waveform support ring 5.

The corners of the first sine wave-shaped support ring 5 are all round corners.

The angle between the wave crest and the wave trough of the first sine wave-shaped support ring 5 is alpha, and the range of the alpha is set to be 45-90 degrees.

The closed type meshes are closed hollow meshes consisting of a plurality of diamond support rings 71 which are distributed along the axial direction; the angle of the first diagonal of the diamond-shaped support ring 71 is 30-120 degrees, and the angle of the second diagonal is 150-60 degrees. The closed mesh structure design can ensure that the stent can cover plaques in a wider range, and the plaque falling-off capability is effectively prevented.

The first link 6 and the second and

third links

75 and 76 are arranged in a straight line type or an S-type or an omega-type, and the length of the second link 75 is 1/4-1/2, preferably 1/3, of the first link 6.

The second mesh structure on the outer stent 4 is a diamond mesh structure to meet the clinical use requirements.

The first mesh structure density of the internal carotid artery stent section 2 on the inner stent 3 is greater than that of the common carotid artery stent section 1; in a single rhombic mesh structure of the second mesh structure, the number of first meshes positioned in the internal carotid artery stent section 2 is 10-100, and the number of first meshes positioned in the common carotid artery stent section 1 is 8-50; the arrangement can effectively ensure that the blood flow passing rate at the position of the common carotid artery is greater than that at the position of the internal carotid artery.

The first mesh structure area of the internal carotid artery stent section 2 on the inner stent 3 is smaller than that of the common carotid artery stent section 1; the area of the first mesh structure positioned on the internal carotid artery stent section 2 is set to be 0.02-6mm²The area of the first mesh structure positioned on the common carotid artery stent section 1 is set to be 1-20mm². The mesh area ensures smoothness of blood flow to the maximum extent and effectively prevents stroke.

The outer layer stent 4 is made of a self-expanding nickel-titanium alloy layer or a cobalt-chromium alloy layer and polyester resin or polyester resin (PET) or expanded polytetrafluoroethylene (e-PTFE) material.

The length range of the internal carotid artery stent section 2 is 8-10 mm; the length range of the common carotid artery stent section 1 is 8-10mm, and the length setting can effectively ensure the distraction effect on the narrow carotid artery.

The diameter range of the internal carotid artery stent section 2 is 5-6 mm; the minimum diameter of the common carotid artery stent section 1 is not less than the diameter of the internal carotid artery stent section 2, and the maximum diameter is less than 10 mm; the device can meet the operation requirements of internal carotid artery and common carotid artery of most patients.

EXAMPLE 2 vascular Stent for application to the carotid artery

The area of the first mesh structure is smaller than that of the second mesh structure, and the area of the first mesh structure is set to be 0.02-20mm²The area of the second mesh structure is set to be 1-30mm²。

The corners of the first sine wave-shaped support ring 5 are all round corners.

The first link 6 and the second and

third links

And a partially-coated film structure is arranged on the outer-layer stent 4, and is made of terylene or polytetrafluoroethylene and used for ensuring the smoothness of blood flow in the external carotid artery.

And a film covering structure is arranged in the area where the closed type meshes are located, and a non-covering structure is arranged in the area where the open type meshes are located.

EXAMPLE 3 vascular Stent for application to the carotid artery

In the adjacent upper and lower first sinusoidal waveform support rings 5, the included angle between the axial connecting line of all wave crests or wave troughs of the upper first sinusoidal waveform support ring 5 and all wave crests or wave troughs of the lower first sinusoidal waveform support ring 5 and the vertical direction is set to be 30-45 degrees, that is, the first sinusoidal waveform support ring 5 is set to be a spiral shape capable of adapting to the twisted shape of the blood vessel.

The corners of the first sine wave-shaped support ring 5 are all round corners.

The closed type meshes are closed hollowed-out meshes consisting of a plurality of second sine wave-shaped support rings 72 which are distributed along the axial direction and are intersected with each other at two adjacent layers, and second connecting pieces 75 which are positioned between the adjacent upper layer second sine wave-shaped support rings 72 and the adjacent lower layer second sine wave-shaped support rings 72; the adjacent upper and lower second sine wave-shaped support rings 72 are connected by a second connector 75, and the second connector 75 is arranged at intervals of 1 week.

The first link 6 and the second and

third links

And a completely-coated film structure is arranged on the outer-layer stent 4, and is made of terylene or polytetrafluoroethylene so as to ensure the smoothness of blood flow in the external carotid artery.

EXAMPLE 4A vascular Stent for application to the carotid artery

The corners of the first sine wave-shaped support ring 5 are all round corners.

The closed type meshes are closed hollowed-out meshes consisting of a plurality of second sine wave-shaped support rings 72 which are distributed along the axial direction and have cross points at two adjacent layers; all the wave crests or wave troughs of the upper second sinusoidal waveform support ring 72 are axially aligned with all the wave crests or wave troughs of the lower second sinusoidal waveform support ring 72, and the wave troughs of the adjacent upper second sinusoidal waveform support ring 72 are overlapped with the wave crests of the lower second sinusoidal waveform support ring 72, and the overlapped area is in a diamond shape.

The first link 6 and the second and

third links

The outer-layer stent 4 is provided with a non-coated film structure, and the film structure is made of terylene or polytetrafluoroethylene and used for ensuring the smoothness of blood flow in the external carotid artery.

The inner surface and/or the outer surface of the inner stent 3 and the inner surface and/or the outer surface of the outer stent 4 are/is provided with a drug coating which can effectively dilute blood or inhibit intimal hyperplasia; wherein the blood diluting medicine coating is heparin and other blood diluting medicines, and the intimal hyperplasia inhibiting medicine coating is paclitaxel, rapamycin and other medicines.

EXAMPLE 5 vascular Stent for application to the carotid artery

The corners of the first sine wave-shaped support ring 5 are all round corners.

The closed type mesh is composed of a plurality of oval support rings 73 which are distributed along the axial direction and have strong radial bearing capacity, adjacent oval support rings 73 which are distributed along the radial direction are connected through second connecting pieces 75, and the edges of adjacent oval support rings 73 which are distributed along the axial direction are integrally connected or connected through third connecting pieces 76.

2 oval support rings 73 are contained in the interval of the first sine wave-shaped support ring 5 in every adjacent 1 circle, and the wave crests or wave troughs of the first sine wave-shaped support ring 5 are connected with the edge of the oval support ring 73 positioned in the middle through a first connecting piece 6, wherein d1 and d2 are connected, and e1 and e2 are connected in sequence as connecting points.

The first link 6 and the second and

third links

EXAMPLE 6 vascular Stent for application to the carotid artery

The area of the first mesh structure is smaller than that of the second mesh structure, and the area of the first mesh structure is set to be 0.02-20mm²The area of the second mesh structure isIs set to be 1-30mm²。

The corners of the first sine wave-shaped support ring 5 are all round corners.

The closed mesh is composed of a plurality of arch support rings 74 which are distributed along the axial direction and have strong retraction resistance; the arch support ring 74 includes a first arch support ring 74 at an upper end and a second arch support ring 74 at a lower end, and the lower end of the first arch support ring 74 is fixedly connected to a port at the upper end of the second arch support ring 74. In addition, adjacent radially distributed arcuate support rings 74 are connected by a second connector 75, and adjacent axially distributed arcuate support rings 74 are connected by a third connector 76.

The interval of the first sine wave-shaped support ring 5 comprises 1 arched support ring 74 in every adjacent 1 circle, and the wave crests or wave troughs of the first sine wave-shaped support ring 5 are connected with the edges of the arched support rings 74 through first connecting pieces 6, wherein f1 and f2 are connecting points and are connected in sequence.

The central angle of the first arched support ring 74 is read to be 120 degrees, and the area of a closed graph formed by connecting lines of the arc length and the two ends of the arc length of the first arched support ring 74 is 0.01-10mm²(ii) a The second arched support ring 74 conforms to the dimensional definition of the first arched support ring 74.

The first link 6 and the second and

third links

The above description of the embodiments is only for the understanding of the present invention. It should be noted that modifications could be made to the invention without departing from the principle of the invention, which would also fall within the scope of the claims of the invention.

Claims

1. A blood vessel stent applied to carotid artery comprises a tubular stent body formed by butting a common carotid artery stent section and an internal carotid artery stent section; the internal carotid artery stent section is a first conical structure which is matched with the shape of a human internal carotid artery blood vessel and extends upwards in an axial conical manner, and the area of the cross section of the upper end of the first conical structure is smaller than that of the cross section of the lower end of the first conical structure; the common carotid artery stent section is of a second conical structure or a straight cylindrical structure which is matched with the common carotid artery blood vessel of a human body and extends upwards in an axial conical manner, the upper end of the second conical structure is consistent with the lower end of the first conical structure in size, the slopes of the second conical structure and the first conical structure are consistent, and the upper end of the straight cylindrical structure is consistent with the lower end of the first conical structure in size; the tubular stent body comprises an inner stent and/or an outer stent, the inner stent is made of a metal material with good biocompatibility, and the outer stent is made of a metal or non-metal material; the utility model discloses a blood flow support, including inlayer support, outer support, first mesh structure, second mesh structure, the first mesh structure that runs through the inlayer support sets up on inlayer support surface the second mesh structure that runs through outer support sets up on outer support surface, and first mesh structure and second mesh structure exist the overlap region of guaranteeing the unobstructed nature of blood flow.

2. The vessel stent applied to carotid artery according to claim 1, wherein the first mesh structure comprises open type meshes located at the upper end of the internal carotid artery stent section and the lower end of the common carotid artery stent section, and closed type meshes located between the open type meshes at both ends.

3. The vessel stent applied to carotid artery according to claim 2, wherein said open mesh is composed of a plurality of first sine wave-shaped support rings with good expansibility distributed along the axial direction, so that the stent can be fully expanded to cling to the inner wall of the vessel; the upper layer and the lower layer of the first sine wave-shaped support ring are connected through a first connecting piece, and only one first connecting piece is arranged between the adjacent upper layer and the lower layer; and two adjacent first connecting pieces are arranged at an interval of 1.5-4.5 weeks, the upper ends of the first connecting pieces are connected with the upper layer first sine wave-shaped support ring, and the lower ends of the first connecting pieces are connected with the lower layer first sine wave-shaped support ring.

4. The vessel stent applied to carotid arteries as claimed in claim 3, wherein all peaks or valleys of any adjacent upper and lower first sinusoidal supporting rings are axially aligned with all peaks or valleys of the lower first sinusoidal supporting ring.

5. The vessel stent applied to carotid artery according to claim 3, wherein the angle between the axial connecting line of all the wave crests or wave troughs of the upper first sine wave-shaped support ring and all the wave crests or wave troughs of the lower first sine wave-shaped support ring and the vertical direction is set to 30-45 degrees in the adjacent upper and lower first sine wave-shaped support rings, that is, the first sine wave-shaped support ring is set to be spiral shape capable of adapting to the twisted configuration of the vessel.

6. The vessel stent applied to carotid artery according to claim 2, wherein the closed type mesh is a closed hollowed-out mesh composed of a plurality of adjacent two layers of non-intersecting second sine wave-shaped support rings distributed along the axial direction, and a second connecting piece positioned between the adjacent upper layer of second sine wave-shaped support rings and the adjacent lower layer of second sine wave-shaped support rings; and a second connecting piece is arranged between the adjacent upper-layer and lower-layer second sine wave-shaped supporting rings and connected with each other, and the second connecting piece is arranged at intervals of 1 week.

7. The vessel stent applied to carotid artery according to claim 2, wherein the closed type meshes are closed hollowed-out meshes composed of a plurality of second sine wave-shaped support rings distributed along the axial direction and with cross points between two adjacent layers; all wave crests or wave troughs of the upper-layer second sine wave-shaped support ring are axially aligned with all wave crests or wave troughs of the lower-layer second sine wave-shaped support ring, the wave troughs of the adjacent upper-layer second sine wave-shaped support ring are overlapped with the wave crests of the lower-layer second sine wave-shaped support ring, and the overlapped area is in a diamond shape.

8. The vessel stent applied to carotid artery according to claim 2, wherein the closed mesh is composed of a plurality of oval support rings with strong radial bearing capacity distributed along the axial direction, the adjacent oval support rings distributed along the radial direction are connected with each other by the second connecting piece, and the edges of the adjacent oval support rings distributed along the axial direction are integrally connected or connected by the third connecting piece.

9. The vessel stent applied to carotid artery according to claim 2, wherein the closed mesh is composed of a plurality of axially distributed arch-shaped support rings with strong anti-retraction capability; the arched support rings comprise a first arched support ring at the upper end and a second arched support ring at the lower end, and the lower end of the first arched support ring is fixedly connected with the port at the upper end of the second arched support ring. In addition, adjacent arch-shaped support rings which are distributed in the radial direction are connected through a second connecting piece, and adjacent arch-shaped support rings which are distributed in the axial direction are connected through a third connecting piece.

10. The vessel stent applied to carotid artery according to claim 9, wherein the central angle of the first arch-shaped support ring is read as 120 degrees, and the area of the closed figure formed by the connection line of the arc length and the two ends of the arc length of the first arch-shaped support ring is 0.01-10mm²(ii) a The second arched support ring conforms to the dimensional definition of the first arched support ring.

11. The vessel stent applied to carotid artery according to claim 2, wherein the first mesh structure density of the stent section of the internal carotid artery on the inner stent is greater than the first mesh structure density of the stent section of the common carotid artery; in a single rhombic mesh structure of the second mesh structure, the number of the first mesh structures positioned in the internal carotid artery stent section is 10-100, and the number of the first mesh structures positioned in the common carotid artery stent section is 8-50.

12. The vessel stent applied to carotid artery according to claim 11, wherein the first mesh structure area of the stent section of the internal carotid artery on the inner stent is smaller than the first mesh structure area of the stent section of the common carotid artery; the area of the first mesh structure positioned on the internal carotid artery stent section is set to be 0.02-6mm²The area of the first mesh structure positioned on the common carotid artery stent section is set to be 1-20mm²。

13. The vessel stent applied to carotid artery according to claim 12, wherein the closed type mesh is covered and the open type mesh is uncovered.

14. The vessel stent applied to carotid artery according to claim 13, wherein the inner surface and/or the outer surface of the inner stent, the inner surface and/or the outer surface of the outer stent is/are provided with a drug coating capable of effectively diluting blood or inhibiting intimal hyperplasia; wherein the blood diluting medicine coating is heparin and other blood diluting medicines, and the intimal hyperplasia inhibiting medicine coating is paclitaxel, rapamycin and other medicines.