CN112014570A - High-speed C reaction protein analyzer - Google Patents
High-speed C reaction protein analyzer Download PDFInfo
- Publication number
- CN112014570A CN112014570A CN202010840515.8A CN202010840515A CN112014570A CN 112014570 A CN112014570 A CN 112014570A CN 202010840515 A CN202010840515 A CN 202010840515A CN 112014570 A CN112014570 A CN 112014570A
- Authority
- CN
- China
- Prior art keywords
- motor
- sample adding
- lead screw
- sample
- fixedly connected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 title claims description 6
- 108090000623 proteins and genes Proteins 0.000 title claims description 6
- 108010074051 C-Reactive Protein Proteins 0.000 claims abstract description 32
- 102100032752 C-reactive protein Human genes 0.000 claims abstract description 32
- 230000007246 mechanism Effects 0.000 claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 239000000758 substrate Substances 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 12
- 230000009471 action Effects 0.000 abstract description 4
- 230000001965 increasing effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010057249 Phagocytosis Diseases 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000003748 differential diagnosis Methods 0.000 description 2
- 229920001821 foam rubber Polymers 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000008782 phagocytosis Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 102000019040 Nuclear Antigens Human genes 0.000 description 1
- 108010051791 Nuclear Antigens Proteins 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 206010033647 Pancreatitis acute Diseases 0.000 description 1
- 206010033654 Pancreatitis necrotising Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 201000003229 acute pancreatitis Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000003571 opsonizing effect Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000031337 regulation of inflammatory response Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention provides a high-speed C-reactive protein analyzer. In the technical scheme, a screw rod mechanism is used for bearing the lifting table, and the lifting table is driven to move longitudinally by the driving of a first motor; the rotating shaft is driven to rotate by the second motor, the rotating arm is sleeved on the rotating shaft through the mounting ring and is fixed by the jackscrew, so that the rotating arm can rotate under the driving of the second motor; a sample adding pipe is arranged at the tail end of the rotating arm, and the sample adding pipe is driven by a liquid pump to suck and release a sample; based on the structure, the automatic sample adding function can be realized. On this basis, utilize step motor drive carousel rotatory, set up the cell frame on the carousel, the reaction tube is the annular and pegs graft on the cell frame, based on step motor's drive action, makes the reaction tube pass through application of sample mechanism below one by one to accomplish the application of sample action. On the basis, an infrared detector can be further introduced to monitor the liquid level condition in the sample adding pipe so as to avoid the phenomenon of adding missing.
Description
Technical Field
The invention relates to the technical field of medical detection, in particular to a high-speed C-reactive protein analyzer.
Background
C-reactive protein (CRP) refers to a number of proteins that rise sharply in the plasma (acute proteins) when the body is infected or tissue damaged. CRP can activate complement and enhance phagocytosis of phagocyte to play an opsonizing role, thereby eliminating pathogenic microorganism and damaged, necrotic and apoptotic histiocyte invading the body, and playing an important protective role in the natural immune process of the body.
CRP is not only a non-specific inflammation marker, but also directly participates in cardiovascular diseases such as inflammation and atherosclerosis, and is the most powerful predictor and risk factor for cardiovascular diseases. The interaction of CRP with complement Clq and FcTR allows it to exhibit a number of biological activities, including host defense against infection, phagocytosis and regulation of inflammatory responses, etc. The combination of the antigen and damaged cells, apoptotic cells and nuclear antigens plays an important role in autoimmune diseases
CRP assays are of great clinical significance.
(1) After the attack of various diseases such as acute inflammation, tissue injury, myocardial infarction, surgical trauma, radiation injury and the like, the disease rapidly rises for hours and has the potential of increasing by times. When the pathological changes are improved, the pathological changes are quickly reduced to normal, and the increasing amplitude of the pathological changes is positively correlated with the infection degree. CRP of a patient after the operation is increased, CRP level is reduced after 7-10 days of the operation, if CRP is not reduced or increased again, infection or thromboembolism possibly occurs.
(2) CRP has close correlation with other inflammatory factors such as total leukocyte count, erythrocyte sedimentation rate and polymorphonuclear leukocytes. And positively correlated with WBCs. Plays a positive role in inflammatory reaction and endows the human body with nonspecific resistance. The patient can rise earlier than WBC at the onset of disease, and can recover to normal quickly, so the sensitivity is extremely high.
(3) Helping to distinguish the type of respiratory infection. CRP can be used for differential diagnosis of bacterial and viral infections: elevation of CRP levels upon bacterial infection; when the virus is infected, CRP is not increased or slightly increased, so that CRP value can help doctors to distinguish types of respiratory tract infection and give medicines and treatment in a targeted mode.
(4) The CRP of malignant tumor patients is increased, such as the joint detection of CRP and AFP, can be used for the differential diagnosis of liver cancer and liver benign diseases, and can be used for the judgment of liver cancer curative effect and prognosis. CRP increased before surgery and decreased after surgery, and its response was not affected by radiotherapy, chemotherapy, and corticoid treatment, which helps to assess tumor progression.
(5) The severity of acute pancreatitis was assessed and when CRP was higher than 250mg/L, extensive necrotizing pancreatitis was suggested.
(6) The CRP can be measured by hypersensitivity latex enhancement method, and the sensitivity of measurement can be improved, and the method can be used for predicting coronary heart disease and myocardial infarction risk.
The C-reactive protein analyzer is an immunoassay analyzer which detects the concentration of C-reactive protein in blood by adopting an immune scattering turbidimetry method or a colloidal gold method. At present, a semi-quantitative analyzer based on a colloidal gold method generally needs manual sample adding, so that the degree of automation is low, the operation is complex, and the detection efficiency is low.
Disclosure of Invention
The invention aims to provide a high-speed C-reactive protein analyzer aiming at the technical defects of the prior art, and aims to solve the technical problem that the conventional C-reactive protein analyzer cannot automatically sample.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
the high-speed C reaction protein analyzer comprises a sample adding mechanism and a bearing mechanism, wherein the sample adding mechanism is arranged on the side of the bearing mechanism;
the sample adding mechanism comprises a bottom plate, a lead screw, a first motor, a first belt, a bevel gear, a lead screw nut, a lifting platform, a second motor, a rotating shaft, a rotating arm, a mounting ring, a sample adding pipe, a liquid pump and a jackscrew, wherein the bottom plate is connected with the lead screw through a bearing, the first motor is in transmission connection with the lead screw through the first belt and the bevel gear, the lead screw nut is screwed on the lead screw, the lead screw nut is fixedly connected with the lifting platform, the lifting platform is fixedly connected with the second motor, and the second motor is in transmission connection with the rotating shaft; the rotating arm is provided with a mounting ring which is sleeved on the rotating shaft, the jackscrew is connected on the mounting ring, the jackscrew penetrates through the mounting ring and is jacked on the rotating shaft, the rotating arm is connected with a sample adding pipe, and the sample adding pipe is connected with a liquid pump;
the bearing mechanism comprises a substrate, a rotary table, a third motor, a gear, a tank frame and a reaction tube, wherein the rotary table is arranged on the substrate, the third motor is fixedly connected to the substrate and is in transmission connection with the gear, a gear ring is arranged on the periphery of the rotary table, and the gear is meshed with the gear ring; the turntable is fixedly connected with a groove frame, and the groove frame is inserted with a reaction tube.
Preferably, the reaction tube further comprises an infrared detector fixedly connected to the substrate, and the infrared detector is positioned on the side of the reaction tube.
Preferably, the sample addition tube is positioned above the reaction tube.
Preferably, the third motor is a stepping motor.
Preferably, the groove frame is annular, a plurality of cylindrical blind holes are formed in the upper end of the groove frame, a spongy cushion is fixedly connected to the bottom end of each blind hole, the reaction tubes are inserted into the blind holes, and the spongy cushion is supported at the bottom ends of the reaction tubes.
The invention provides a high-speed C-reactive protein analyzer. In the technical scheme, a screw rod mechanism is used for bearing the lifting table, and the lifting table is driven to move longitudinally by the driving of a first motor; the rotating shaft is driven to rotate by the second motor, the rotating arm is sleeved on the rotating shaft through the mounting ring and is fixed by the jackscrew, so that the rotating arm can rotate under the driving of the second motor; a sample adding pipe is arranged at the tail end of the rotating arm, and the sample adding pipe is driven by a liquid pump to suck and release a sample; based on the structure, the automatic sample adding function can be realized. On this basis, utilize step motor drive carousel rotatory, set up the cell frame on the carousel, the reaction tube is the annular and pegs graft on the cell frame, based on step motor's drive action, makes the reaction tube pass through application of sample mechanism below one by one to accomplish the application of sample action. On the basis, an infrared detector can be further introduced to monitor the liquid level condition in the sample adding pipe so as to avoid the phenomenon of adding missing. The invention can effectively improve the detection efficiency and reduce the experimental operation amount, and has outstanding technical advantages.
Drawings
FIG. 1 is a front view of a sample application mechanism according to the present invention;
FIG. 2 is a perspective view of a pivot arm and its upper assembly in accordance with the present invention;
FIG. 3 is a perspective view of a load bearing mechanism of the present invention;
in the figure:
1. bottom plate 2, lead screw 3, first motor 4, first belt
5. Bevel gear 6, lead screw nut 7, elevating platform 8, second motor
9. Rotating shaft 10, rotating arm 11, mounting ring 12 and sample adding pipe
13. Liquid pump 14, jackscrew 15, base plate 16, carousel
17. Third motor 18, gear 19, groove frame 20 and reaction tube
21. An infrared detector.
Detailed Description
Hereinafter, specific embodiments of the present invention will be described in detail. Well-known structures or functions may not be described in detail in the following embodiments in order to avoid unnecessarily obscuring the details. Approximating language, as used herein in the following examples, may be applied to identify quantitative representations that could permissibly vary in number without resulting in a change in the basic function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
Example 1
A high-speed C-reactive protein analyzer is shown in figures 1-3 and comprises a sample adding mechanism and a bearing mechanism, wherein the sample adding mechanism is arranged on the side of the bearing mechanism;
the sample adding mechanism comprises a bottom plate 1, a lead screw 2, a first motor 3, a first belt 4, a bevel gear 5, a lead screw nut 6, a lifting table 7, a second motor 8, a rotating shaft 9, a rotating arm 10, a mounting ring 11, a sample adding pipe 12, a liquid pump 13 and a jackscrew 14, wherein the lead screw 2 is connected to the bottom plate 1 through a bearing, the first motor 3 is in transmission connection with the lead screw 2 through the first belt 4 and the bevel gear 5, the lead screw nut 6 is screwed on the lead screw 2, the lead screw nut 6 is fixedly connected with the lifting table 7, the second motor 8 is fixedly connected to the lifting table 7, and the second motor 8 is in transmission connection with the rotating shaft 9; the rotating arm 10 is provided with a mounting ring 11, the mounting ring 11 is sleeved on the rotating shaft 9, a jackscrew 14 is connected on the mounting ring 11 through a screw, the jackscrew 14 penetrates through the mounting ring 11 and is pressed on the rotating shaft 9, the rotating arm 10 is connected with a sample adding pipe 12, and the sample adding pipe 12 is connected with a liquid pump 13;
the bearing mechanism comprises a substrate 15, a turntable 16, a third motor 17, a gear 18, a groove frame 19 and a reaction tube 20, wherein the turntable 16 is arranged on the substrate 15, the third motor 17 is fixedly connected to the substrate 15, the third motor 17 is in transmission connection with the gear 18, a gear ring is arranged on the periphery of the turntable 16, and the gear 18 is meshed with the gear ring; the turntable 16 is fixedly connected with a groove frame 19, and a reaction tube 20 is inserted on the groove frame 19.
Example 2
A high-speed C-reactive protein analyzer is shown in figures 1-3 and comprises a sample adding mechanism and a bearing mechanism, wherein the sample adding mechanism is arranged on the side of the bearing mechanism;
the sample adding mechanism comprises a bottom plate 1, a lead screw 2, a first motor 3, a first belt 4, a bevel gear 5, a lead screw nut 6, a lifting table 7, a second motor 8, a rotating shaft 9, a rotating arm 10, a mounting ring 11, a sample adding pipe 12, a liquid pump 13 and a jackscrew 14, wherein the lead screw 2 is connected to the bottom plate 1 through a bearing, the first motor 3 is in transmission connection with the lead screw 2 through the first belt 4 and the bevel gear 5, the lead screw nut 6 is screwed on the lead screw 2, the lead screw nut 6 is fixedly connected with the lifting table 7, the second motor 8 is fixedly connected to the lifting table 7, and the second motor 8 is in transmission connection with the rotating shaft 9; the rotating arm 10 is provided with a mounting ring 11, the mounting ring 11 is sleeved on the rotating shaft 9, a jackscrew 14 is connected on the mounting ring 11 through a screw, the jackscrew 14 penetrates through the mounting ring 11 and is pressed on the rotating shaft 9, the rotating arm 10 is connected with a sample adding pipe 12, and the sample adding pipe 12 is connected with a liquid pump 13;
the bearing mechanism comprises a substrate 15, a turntable 16, a third motor 17, a gear 18, a groove frame 19 and a reaction tube 20, wherein the turntable 16 is arranged on the substrate 15, the third motor 17 is fixedly connected to the substrate 15, the third motor 17 is in transmission connection with the gear 18, a gear ring is arranged on the periphery of the turntable 16, and the gear 18 is meshed with the gear ring; the turntable 16 is fixedly connected with a groove frame 19, and a reaction tube 20 is inserted on the groove frame 19.
Meanwhile, the device also comprises an infrared detector 21, wherein the infrared detector 21 is fixedly connected to the substrate 15, and the infrared detector 21 is positioned on the side of the reaction tube 20. The sample addition tube 12 is located above the reaction tube 20. The third motor 17 is a stepping motor. The groove frame 19 is annular, has seted up a plurality of columniform blind holes in the upper end of groove frame 19 the bottom fixedly connected with foam-rubber cushion of blind hole, reaction tube 20 pegs graft in the blind hole, the foam-rubber cushion bearing is in reaction tube 20 bottom.
The embodiments of the present invention have been described in detail, but the description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The high-speed C reaction protein analyzer is characterized by comprising a sample adding mechanism and a bearing mechanism, wherein the sample adding mechanism is arranged on the side of the bearing mechanism;
the sample adding mechanism comprises a bottom plate (1), a lead screw (2), a first motor (3), a first belt (4), a bevel gear (5), a lead screw nut (6), a lifting platform (7), a second motor (8), a rotating shaft (9), a rotating arm (10), a mounting ring (11), a sample adding pipe (12), a liquid pump (13) and a jackscrew (14), wherein the lead screw (2) is connected to the bottom plate (1) through a bearing, the first motor (3) is in transmission connection with the lead screw (2) through the first belt (4) and the bevel gear (5), the lead screw nut (6) is screwed to the lead screw (2), the lead screw nut (6) is fixedly connected with the lifting platform (7), the second motor (8) is fixedly connected to the lifting platform (7), and the second motor (8) is in transmission connection with the rotating shaft (9); the rotary arm (10) is provided with a mounting ring (11), the mounting ring (11) is sleeved on the rotating shaft (9), a top wire (14) is connected on the mounting ring (11), the top wire (14) penetrates through the mounting ring (11) and is pressed on the rotating shaft (9), the rotary arm (10) is connected with a sample adding pipe (12), and the sample adding pipe (12) is connected with a liquid pump (13);
the bearing mechanism comprises a substrate (15), a turntable (16), a third motor (17), a gear (18), a groove frame (19) and a reaction tube (20), wherein the turntable (16) is arranged on the substrate (15), the third motor (17) is fixedly connected to the substrate (15), the third motor (17) is in transmission connection with the gear (18), a gear ring is arranged on the periphery of the turntable (16), and the gear (18) is meshed with the gear ring; the turntable (16) is fixedly connected with a groove frame (19), and the groove frame (19) is spliced with a reaction tube (20).
2. The high-speed C-reactive protein analyzer according to claim 1, further comprising an infrared detector (21), wherein the infrared detector (21) is fixedly connected to the substrate (15), and the infrared detector (21) is located at the side of the reaction tube (20).
3. The high speed C-reactive protein analyzer of claim 1, wherein the sample application tube (12) is positioned above the reaction tube (20).
4. The high speed C-reactive protein analyzer of claim 1, wherein the third motor (17) is a stepper motor.
5. The high-speed C-reactive protein analyzer according to claim 1, wherein the tank rack (19) is annular, the upper end of the tank rack (19) is provided with a plurality of cylindrical blind holes, the bottom ends of the blind holes are fixedly connected with sponge pads, the reaction tubes (20) are inserted into the blind holes, and the sponge pads are supported at the bottom ends of the reaction tubes (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010840515.8A CN112014570A (en) | 2020-08-20 | 2020-08-20 | High-speed C reaction protein analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010840515.8A CN112014570A (en) | 2020-08-20 | 2020-08-20 | High-speed C reaction protein analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112014570A true CN112014570A (en) | 2020-12-01 |
Family
ID=73505230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010840515.8A Pending CN112014570A (en) | 2020-08-20 | 2020-08-20 | High-speed C reaction protein analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112014570A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201974433U (en) * | 2011-02-14 | 2011-09-14 | 四川迈克生物科技股份有限公司 | Automation device used for sample adding and reaction tube loading |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| CN206450684U (en) * | 2017-01-25 | 2017-08-29 | 无锡克劳斯麦迪医疗仪器有限公司 | Chemiluminescent analyzer reagent disc mounting structure |
| CN207866718U (en) * | 2018-02-10 | 2018-09-14 | 王鲁生 | A kind of fully-automatic intelligent urine iodine analyzer |
-
2020
- 2020-08-20 CN CN202010840515.8A patent/CN112014570A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201974433U (en) * | 2011-02-14 | 2011-09-14 | 四川迈克生物科技股份有限公司 | Automation device used for sample adding and reaction tube loading |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| CN206450684U (en) * | 2017-01-25 | 2017-08-29 | 无锡克劳斯麦迪医疗仪器有限公司 | Chemiluminescent analyzer reagent disc mounting structure |
| CN207866718U (en) * | 2018-02-10 | 2018-09-14 | 王鲁生 | A kind of fully-automatic intelligent urine iodine analyzer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| von Herbay et al. | Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid | |
| Nagasawa et al. | Association of white blood cell count and clustered components of metabolic syndrome in Japanese men | |
| Paruk et al. | Monitoring the post surgery inflammatory host response | |
| Basyreva et al. | Effect of vitamin D3 in combination with omega-3 polyunsaturated fatty acids on NETosis in type 2 diabetes mellitus patients | |
| Bunout et al. | Interleukin 1 and tumor necrosis factor in obese alcoholics compared with normal-weight patients | |
| CN112014570A (en) | High-speed C reaction protein analyzer | |
| CN112014571A (en) | Semi-quantitative detection device for C-reactive protein colloidal gold method | |
| Zhao et al. | Association of bone metabolism indices and bone mineral density with diabetic retinopathy in elderly patients with type 2 diabetes mellitus: a cross-sectional inpatient study in China | |
| Godfrey et al. | Diagnosis of Gambian trypanosomiasis in man by isolating trypanosomes from blood passed through DEAE-cellulose | |
| Sun et al. | Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors | |
| Uzan et al. | Pleural effusion in end stage renal failure patients | |
| RU2384297C1 (en) | Method for prediction of postoperative complications in oncological patients | |
| Ali et al. | Role of IL-6 in urinary tract infection among diabetic and non-diabetic patients | |
| Rosyadi et al. | Acute phase protein serum amyloid a (SAA) profile in diabetic Wistar rats induced streptozotocin | |
| Alberti et al. | Acute heart failure caused by parvovirus B-19 myocarditis treated with human immunoglobulin | |
| Biran et al. | Phototherapy decreases red blood cell deformability in patients with psoriasis | |
| Yang et al. | The Role of Gold Nanorods in Detecting Circulating microRNAs as Biomarkers in Liver Diseases | |
| RU2642600C1 (en) | Method of the early postoperative period course estimation in patients operated for chronic rheumatic heart disease | |
| Ali | ABO and Rhesus Grouping among Sudanese Patients with Coronary Artery Disease at Sudan Heart Center-Khartoum State | |
| Luhulima et al. | Neutrophil-Lymphocyte count ratio in bacterial sepsis | |
| AL-Azzawi et al. | Prevalence of Helicobacter Pyloriin Children with Type 1 Diabetes Mellitus and its Association with C-peptide and HbA1c | |
| Ali et al. | Emphysematous pyelonephritis: a review of six cases | |
| Monsel et al. | Focusing on the alveolar epithelium: Alveolar fluid clearance in ciffuse versus focal ARDS | |
| Gromadzka et al. | Tu-P10: 443 Plasma lipids and markers of inflammation in patients with a 6-months history of myocardial infarction or stroke | |
| Hoxha et al. | Cardioembolic Stroke at Prosthetic valve endocarditis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |