CN112014354A - OCT reference arm optical path determination and adjustment method and device, storage medium and terminal - Google Patents
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Abstract
The invention discloses an OCT reference arm optical path judging and adjusting method, a device, a storage medium and a terminal, wherein in the constant-speed change process of the optical path of a reference arm, the optical path equality degree calculated according to a real-time feedback image is recorded, the optimal optical path equality position is searched and calculated by using the recorded optical path equality degree data, and the optical path of the reference arm is adjusted to be equal to the optical path of a sample arm; the numerical values obtained by extracting the products of a plurality of columns in the middle of the chromatographic image and a specific normal distribution array are equal in optical path length, and the algorithm has the characteristics of high operation speed, less memory occupation and capability of reflecting the correlation degree of the sample image at the designated position of the whole chromatographic image; the optimal interference OCT tomography image can be obtained by starting optical path adjustment once and quickly and automatically adjusting the reference arm without a professional, and the operation difficulty of related users is reduced.
Description
Technical Field
The invention relates to the technical field of medical imaging, in particular to an OCT reference arm optical path judging and adjusting method, device, storage medium and terminal based on image feedback.
Background
Compared with the existing Tomography (X-ray CT, nuclear magnetic resonance CT and ultrasonic CT), the Optical Coherence Tomography (OCT for short) has the advantages of no contact, no damage, clear imaging, etc. The OCT technology is widely used in the medical field, and can be used for early diagnosis of some diseases such as ophthalmology, dermatology, otology, and cardiovascular disease. It also has wide application in materials and basic research.
When the OCT technology is expanded to imaging biological tissues, it utilizes the principle of optical interference to image, which is simply to divide light emitted from a light source into two beams, one beam is emitted to a measured object (e.g., fundus tissue), this beam is called a sample arm, the other beam is emitted to a reference reflector, called a reference arm, and two beams of optical signals reflected from the tissue (sample arm) and the reflector (reference arm) are superposed, and when the optical path lengths of the sample arm and the reference arm are consistent, interference occurs; the photoelectric sensor converts the optical interference signal into an electric signal, and the electric signal is subjected to data post-processing to generate a tomography image of the detected tissue.
Based on the optical interference imaging principle, the reference arm and the sample arm need to be in a conjugate state, and the optimal imaging effect can be obtained by the OCT system only when the optical path stroke lengths of the reference arm and the sample arm are consistent. However, in the conventional OCT system, the optical paths of the reference arm and the sample arm are conjugated through manual or electric adjustment, and when a certain parameter of the sample arm is changed, that is, the length of the sample arm is changed, for example, when the sample arm is replaced, the reference arm and the sample arm cannot generate an interference phenomenon, and the reference arm needs to be adjusted again. Whether the reference arm is adjusted manually or electrically, the OCT system requires the operator to have the professional knowledge related to the OCT imaging system for adjusting the optical path of the reference arm, which is inconvenient for the operator to operate and troublesome in the adjustment process.
Therefore, the prior art still needs to be improved and developed.
Disclosure of Invention
The invention aims to provide an OCT reference arm optical path determining and adjusting method, an OCT reference arm optical path determining and adjusting device, a storage medium and a terminal, and aims to solve the problems that in an existing OCT system, reference arm adjustment requires operators to have relevant professional knowledge of an OCT imaging system, adjustment operation is inconvenient, and the adjustment process is troublesome.
The technical scheme of the invention is as follows: an optical path judging and adjusting method for an OCT reference arm specifically comprises the following steps:
s10: sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one extreme end point to the other extreme end point;
s20: processing the sequentially acquired tomographic images one by one, extracting a plurality of rows from each tomographic image and placing the rows into a row-column array;
s30: constructing a normal distribution array comprising the expectation and standard deviation;
s40: the optical path equal-degree number of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image is calculated through the row-column array and the normal distribution array;
s50: putting the obtained equal degree number into an equal degree array;
s60: judging whether a plurality of tomographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point, if so, skipping to S70, otherwise, skipping to S20;
s70: searching an index where the maximum value of the equality degree is located from the equality degree array;
s80: calculating the stroke percentage of the aplanatism according to the index of the maximum value of the aplanatism degree and the length of the equal degree array;
s90: and calculating and outputting the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage.
The OCT reference arm optical path length judgment and adjustment method is characterized in that the reference arm moves from one limit end point to the other limit end point at a constant speed.
According to the OCT reference arm optical path determining and adjusting method, the expectation and the standard deviation of the normal distribution array are related to the number of rows of the tomographic image.
In the OCT reference arm optical path determining and adjusting method, in S80, a calculation formula of a stroke percentage is as follows:
where N is the length of the equality degree array, and Index is the Index where the maximum equality degree value is located.
In the OCT reference arm optical path length determination and adjustment method, in S90, a calculation formula of a position where the optical paths of the reference arm and the sample arm are equal is as follows:
wherein P1 is one extreme point and P2 is the other extreme point.
In the OCT reference arm optical path length determination adjustment method, in S40, the equation for calculating the equal path degree is as follows:
where Row is the number of rows in the tomogram, Col is the number of columns extracted from the tomogram, Normal [ i ]]Is a normally distributed array, Input [ j][i]Is a row-column array for storing several rows of data extracted from a tomographic image.
An apparatus for using the OCT reference arm optical path determination adjustment method according to any one of the above methods, comprising:
the tomographic image acquisition module is used for sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one limit end point to the other limit end point;
the row-column array module is used for processing the sequentially acquired chromatographic images one by one, extracting a plurality of rows from each chromatographic image and placing the rows into a row-column array;
the normal distribution array module is used for constructing a normal distribution array comprising expectation and standard deviation;
the equal-degree module is used for solving the equal-degree of the optical paths of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image through the row-column array and the normal distribution array;
the equality degree array module is used for putting the obtained equality degree number into an equality degree array;
the judgment module is used for judging whether a plurality of chromatographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point;
the index searching module is used for searching the index where the maximum value of the equal degree is located from the equal degree array;
the stroke percentage calculation module is used for calculating the stroke percentage of the aplanatism through the index of the maximum value of the aplanatism degree and the length of the equal degree array;
and the optical path equal position calculation module calculates and outputs the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage.
The device, wherein, the reference arm is moved from one extreme end point to the other extreme end point at a constant speed through an electric optical delay line.
A terminal comprising a processor and a memory, the memory having stored therein a computer program, the processor being adapted to perform the method of any preceding claim by invoking the computer program stored in the memory.
A storage medium having stored therein a computer program which, when run on a computer, causes the computer to perform any of the methods described above.
The invention has the beneficial effects that: the invention provides an OCT reference arm optical path judging and adjusting method, a device, a storage medium and a terminal, wherein in the constant-speed change process of the optical path of a reference arm, the optical path equality degree calculated according to a real-time feedback image is recorded, the optimal optical path equality position is searched and calculated by using the recorded optical path equality degree data, and the optical path of the reference arm is adjusted to be equal to the optical path of a sample arm; the numerical values obtained by extracting the products of a plurality of columns in the middle of the chromatographic image and a specific normal distribution array are equal in optical path length, and the algorithm has the characteristics of high operation speed, less memory occupation and capability of reflecting the correlation degree of the sample image at the designated position of the whole chromatographic image; the optimal interference OCT tomography image can be obtained by starting optical path adjustment once and quickly and automatically adjusting the reference arm without a professional, and the operation difficulty of related users is reduced.
Drawings
FIG. 1 is a flow chart of the steps of the OCT reference arm optical path length determination and adjustment method in the invention.
FIG. 2 is a schematic diagram of a tomographic image acquired by the OCT system of the present invention.
Fig. 3 is a schematic view of the apparatus of the present invention.
FIG. 4 is a schematic diagram of an electro-optic delay line according to the present invention.
Fig. 5 is a schematic diagram of a terminal in the present invention.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present application without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures. Meanwhile, in the description of the present application, the terms "first", "second", and the like are used only for distinguishing the description, and are not to be construed as indicating or implying relative importance.
As shown in fig. 1, an OCT reference arm optical path determining and adjusting method based on image feedback specifically includes the following steps:
s0: and starting adjustment and waiting for the OCT system to send out an adjustment reference arm signal.
S1: two limit end points of the movement of the reference arm are preset, the reference arm is driven to move from one limit end point to the other limit end point, and a plurality of tomographic images generated by the OCT system in the movement process of the reference arm are sequentially acquired.
Wherein the optimum position for adjustment of the reference arm is between the two extreme end points when the sample arm is changed. Referring to fig. 4, the values of the positive and negative limits are read, the mirror of the reference arm is driven to move at a constant speed (to ensure the uniformity of sampling) from one end of the positive and negative limits to the other end, and the acquisition of the tomographic image generated by the OCT system is started, and the process goes to S2.
S2: sequentially collected tomographic images (as shown in fig. 2, the tomographic images vertically correspond to the depth direction of the detection sample) are processed one by one, if the sizes of the tomographic images are Row rows and C columns, Row rows and Col columns (Col columns are less than C columns) are extracted from the middle of the images and are placed in an array Input [ Col ] [ Row ], and the process goes to S3.
S3: constructing a Normal distribution array Normal [ Row ] with the expectation of μ and standard deviation σ, and the expectation of μ and standard deviation σ being related to Row, can make the inspection sample image in the ideal position of the tomographic image after the adjustment is finished (e.g., μ =0.5 x Row, σ =0.125 x Row), and go to S4.
S4: according to the principle that the optical paths of the reference arm and the sample arm are equal, the interference signal is strongest, and the brightness of the chromatographic image is strongest, the following formula is adopted to obtain the Input [ Col ]][Row]And Normal [ Row ]]Determining whether the reference arm is moving to the webThe optical path equal-degree E of the reference arm and the sample arm at the corresponding position of the chromatographic image reflects the degree of the sample image at the specified position of the chromatographic image, and the formula is
Go to S5.
S5: the equality degree number E is placed in the equality degree array EArray [ N ], and S6 is passed.
S6: it is determined whether the reference arm has moved to the limit point P2 (i.e., whether all tomographic images generated by the OCT system have been acquired and processed), and if not, the process proceeds to S2, and if so, the process proceeds to S7.
S7: from the equality degree array EArray [ N ], the Index where the maximum value of the equality degree E is located is found, and the process goes to S8.
S8: by the formula
The percentage Delta of travel at which the aplanatism is found is determined and the process goes to S9.
S9: by the formula
The position Pe at which the optical paths of the reference arm and the sample arm are most likely to be equal is calculated, and the process goes to S10.
S10: the reference arm is driven to be positioned to the point Pe so that the reference arm and the sample arm are in an optimal aplanatic state.
As shown in fig. 3, an apparatus adopting the OCT reference arm optical path length determination adjustment method based on image feedback as described above includes:
a tomographic image acquisition module 100, which sequentially acquires a plurality of tomographic images generated by the OCT system during the movement of the reference arm from one extreme end point to another extreme end point;
a row-column array module 200, which processes the sequentially acquired tomographic images one by one, extracts a plurality of columns from each tomographic image and places the columns into a row-column array;
a normal distribution array module 300 for constructing a normal distribution array including an expectation and a standard deviation;
the equal degree module 400 is used for calculating the equal degree of the optical path of the reference arm and the optical path of the sample arm when the reference arm moves to the position corresponding to the chromatographic image through the row-column array and the normal distribution array;
the equality degree array module 500 is used for putting the obtained equality degree number into an equality degree array;
the judging module 600 judges whether the plurality of tomographic images generated by the OCT system have been completely collected and processed while the reference arm moves from one limit end point to another limit end point;
the index searching module 700 is used for searching the index where the maximum value of the equality degree is located from the equality degree array;
the stroke percentage calculation module 800 is used for calculating the stroke percentage of the aplanatic path according to the index of the maximum value of the equal degree and the length of the equal degree array;
the path length equality position calculation module 900 calculates and outputs the position for equalizing the path lengths of the reference arm and the sample arm from the two extreme points and the stroke percentage.
In some embodiments, the reference arm is driven to move from one limit end to another limit end by an electrical optical delay line, the electrical optical delay line includes a first limit installation part 101, a second limit installation part 102, a lead screw 103, a slider 104, and a motor 105, wherein one limit end is disposed on the first limit installation part 101, the other limit end is disposed on the second limit installation part 102, one end of the lead screw 103 is installed on the first limit installation part 101, the other end of the lead screw 103 passes through the second limit installation part 102 and is connected with the motor 105, the lead screw 103 is driven by the motor 105 to rotate, the slider 104 is disposed on the lead screw 103 and moves back and forth along the lead screw 103 with the rotation of the lead screw 103, the mirror 106 of the reference arm is disposed on the slider 104, and the optical fiber and collimator 107 are disposed on the first limit installation part 101: and starting a motor 105 to drive a screw rod 103 to rotate, so that a slide block 104 drives a reflector 106 of a reference arm to move from one limit end point to the other limit end point at a constant speed along the screw rod 103, and light rays emitted by the OCT system are transmitted to the reflector 106 of the reference arm through an optical fiber and a collimator 107 and then are reflected back to the OCT system, thereby realizing the acquisition of a chromatographic image.
The OCT system can control the optical path of the reference arm to increase or decrease at a constant speed through an electric signal by using an electric optical delay line as a reference arm optical path adjusting device of the OCT system and controlling the optical delay line to run, position and stop; and acquiring positive and negative limit position values of the optical delay line through electric signals.
Compared with the prior art, the technical scheme has the following advantages:
(1) according to the technical scheme, the reference arm can be adjusted to the state most equal to the sample arm only by one signal for starting the adjustment of the reference arm; after the parameters of the sample arm are changed, the OCT system can quickly and automatically adjust the reference arm without a professional, so that the optimal interference signal and OCT imaging effect are obtained, and the operation difficulty of related users is reduced.
(2) According to the technical scheme, products of a plurality of columns in the middle of a chromatographic image and a specific normal distribution array are extracted and then summed, and the obtained numerical value is the optical path equality degree; the algorithm has the characteristics of high operation speed, less occupied internal memory and capability of reflecting the correlation degree of the sample image at the designated position of the whole chromatographic image.
(3) The technical scheme provides that the electric optical delay line is used as an element for adjusting the optical path of the reference arm of the OCT system, so that the OCT system can control the optical path of the reference arm to change at a constant speed and adjust to a specified position.
(4) According to the technical scheme, in the constant-speed change process of the optical path of the reference arm, the optical path equality degree calculated according to a real-time feedback image is recorded, the optimal optical path equality position is searched and calculated by using the recorded optical path equality degree data, and the optical path of the reference arm is adjusted through an electric optical delay line to be equal to the optical path of the sample arm.
Referring to fig. 5, an embodiment of the present invention further provides a terminal. As shown, terminal B300 includes a processor B301 and a memory B302. The processor B301 is electrically connected to the memory B302. The processor B301 is a control center of the terminal B300, connects various parts of the entire terminal using various interfaces and lines, and performs various functions of the terminal and processes data by running or calling a computer program stored in the memory B302 and calling data stored in the memory B302, thereby performing overall monitoring of the terminal B300.
In this embodiment, the processor B301 in the terminal B300 loads instructions corresponding to one or more computer program processes into the memory B302 according to the following steps, and the processor B301 runs the computer program stored in the memory B302, so as to implement various functions: sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one extreme end point to the other extreme end point; processing the sequentially acquired chromatographic images one by one, extracting a plurality of columns from each chromatographic image and placing the columns into a row-column array; constructing a normal distribution array comprising the expectation and standard deviation; calculating the degree of the equal distance of the optical paths of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image through the row-column array and the normal distribution array; putting the obtained equal degree number into an equal degree array; judging whether a plurality of chromatographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point, if so, continuing to the next step, and if not, continuing to perform the chromatographic image processing process on the next chromatographic image; searching an index where the maximum value of the equality degree is located from the equality degree array; calculating the stroke percentage of the aplanatism by the index and the length of the equal degree array; and calculating and outputting the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage.
Memory B302 may be used to store computer programs and data. The memory B302 stores a computer program containing instructions executable in the processor. The computer program may constitute various functional modules. The processor B301 executes various functional applications and data processing by calling a computer program stored in the memory B302.
An embodiment of the present application provides a storage medium, and when being executed by a processor, the computer program performs a method in any optional implementation manner of the foregoing embodiment to implement the following functions: sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one extreme end point to the other extreme end point; processing the sequentially acquired tomographic images one by one, extracting a plurality of rows from each tomographic image and placing the rows into a row-column array; constructing a normal distribution array comprising the expectation and standard deviation; calculating the degree of the equal distance of the optical paths of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image through the row-column array and the normal distribution array; putting the obtained equal degree number into an equal degree array; judging whether a plurality of chromatographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point, if so, continuing to the next step, and if not, continuing to perform the chromatographic image processing process on the next chromatographic image; searching an index where the maximum value of the equality degree is located from the equality degree array; calculating the stroke percentage of the aplanatism by the index and the length of the equal degree array; and calculating and outputting the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage. The storage medium may be implemented by any type of volatile or nonvolatile storage device or combination thereof, such as a Static Random Access Memory (SRAM), an Electrically Erasable Programmable Read-Only Memory (EEPROM), an Erasable Programmable Read-Only Memory (EPROM), a Programmable Read-Only Memory (PROM), a Read-Only Memory (ROM), a magnetic Memory, a flash Memory, a magnetic disk, or an optical disk.
In the embodiments provided in the present application, it should be understood that the disclosed apparatus and method may be implemented in other ways. The above-described embodiments of the apparatus are merely illustrative, and for example, the division of the units is only one logical division, and there may be other divisions when actually implemented, and for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection of devices or units through some communication interfaces, and may be in an electrical, mechanical or other form.
In addition, units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
Furthermore, the functional modules in the embodiments of the present application may be integrated together to form an independent part, or each module may exist separately, or two or more modules may be integrated to form an independent part.
In this document, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions.
The above description is only an example of the present application and is not intended to limit the scope of the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. An OCT reference arm optical path judging and adjusting method is characterized by comprising the following steps:
s10: sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one extreme end point to the other extreme end point;
s20: processing the sequentially acquired tomographic images one by one, extracting a plurality of rows from each tomographic image and placing the rows into a row-column array;
s30: constructing a normal distribution array comprising the expectation and standard deviation;
s40: the optical path equal-degree number of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image is calculated through the row-column array and the normal distribution array;
s50: putting the obtained equal degree number into an equal degree array;
s60: judging whether a plurality of tomographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point, if so, skipping to S70, otherwise, skipping to S20;
s70: searching an index where the maximum value of the equality degree is located from the equality degree array;
s80: calculating the stroke percentage of the aplanatism according to the index of the maximum value of the aplanatism degree and the length of the equal degree array;
s90: and calculating and outputting the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage.
2. The OCT reference arm optical path length decision adjustment method of claim 1, wherein the reference arm is moved at a constant speed from one extreme end point to another extreme end point.
3. The OCT reference arm optical path length decision adjustment method of claim 1, wherein the expectation and standard deviation of the normal distribution array are related to the number of rows of the tomographic image.
4. The OCT reference arm optical path length determination adjustment method according to claim 1, wherein in S80, the calculation formula of the stroke percentage is as follows:
where N is the length of the equivalence array, Index is the index where the maximum value of the degree of equality is located.
5. The OCT reference arm optical path length determination adjustment method according to claim 1, wherein in S90, a calculation formula of a position where the optical paths of the reference arm and the sample arm are equal is as follows:
wherein P1 is one extreme point and P2 is the other extreme point.
6. The OCT reference arm optical path length determination adjustment method according to claim 1, wherein in S40, the equation for calculating the degree of equal path is as follows:
where Row is the number of rows in the tomogram, Col is the number of columns extracted from the tomogram, Normal [ i ]]Is a normally distributed array, Input [ j][i]Is a row-column array for storing several rows of data extracted from a tomographic image.
7. An apparatus for using the OCT reference arm optical path determination adjustment method according to any one of claims 1 to 6, comprising:
the tomographic image acquisition module is used for sequentially acquiring a plurality of tomographic images generated by the OCT system in the process that the reference arm moves from one limit end point to the other limit end point;
the row-column array module is used for processing the sequentially acquired chromatographic images one by one, extracting a plurality of rows from each chromatographic image and placing the rows into a row-column array;
the normal distribution array module is used for constructing a normal distribution array comprising expectation and standard deviation;
the equal-degree module is used for solving the equal-degree of the optical paths of the reference arm and the sample arm when the reference arm moves to the position corresponding to the chromatographic image through the row-column array and the normal distribution array;
the equality degree array module is used for putting the obtained equality degree number into an equality degree array;
the judgment module is used for judging whether a plurality of chromatographic images generated by the OCT system are completely collected and processed in the process that the reference arm moves from one limit end point to the other limit end point;
the index searching module is used for searching the index where the maximum value of the equal degree is located from the equal degree array;
the stroke percentage calculation module is used for calculating the stroke percentage of the aplanatism through the index of the maximum value of the aplanatism degree and the length of the equal degree array;
and the optical path equal position calculation module calculates and outputs the position for enabling the optical paths of the reference arm and the sample arm to be equal through the two limit end points and the stroke percentage.
8. The apparatus of claim 7, wherein the reference arm is moved from one extreme end point to the other extreme end point at a constant speed by an electro-optical delay line.
9. A terminal, characterized in that it comprises a processor and a memory, in which a computer program is stored, the processor being adapted to carry out the method of any one of claims 1 to 6 by calling the computer program stored in the memory.
10. A storage medium having stored thereon a computer program which, when run on a computer, causes the computer to perform the method of any one of claims 1 to 6.
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