CN112007082A

CN112007082A - Juvenile eye health care composition

Info

Publication number: CN112007082A
Application number: CN202010944115.1A
Authority: CN
Inventors: 许池民
Original assignee: Hangzhou Qiandaohu Huayao Biotechnology Co ltd
Current assignee: Hangzhou Qiandaohu Huayao Biotechnology Co ltd
Priority date: 2020-09-10
Filing date: 2020-09-10
Publication date: 2020-12-01

Abstract

The invention discloses a teenager eye health care composition, which comprises the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30 parts of cassia seed or cassia seed extract, 20-30 parts of cowberry or cowberry extract, 10-20 parts of dogwood or dogwood extract, 20-30 parts of honeysuckle or honeysuckle extract, 5-10 parts of pawpaw or pawpaw extract and 10-20 parts of honey. All the raw materials of the invention are medicinal and edible components, are natural and safe, can relieve visual fatigue, effectively improve the near-sightedness period, early near-sightedness and far-sightedness conditions of teenagers, eliminate the symptoms of blurred vision, eyeball fullness, ophthalmalgia, photophobia, dry eye, eyeball soreness and tiredness and the like caused by the visual fatigue, and simultaneously have the effects of clearing heat and removing toxicity, nourishing liver and improving eyesight.

Description

Juvenile eye health care composition

Technical Field

The invention relates to a health-care product, in particular to a composition for eye health care of teenagers.

Background

The eye is the most important organ in human perception, and approximately half of the knowledge and memory in the brain is acquired through the eye. The eyes are needed to read the books and recognize words, watch pictures, watch figures, enjoy beautiful scenery and the like. The eyes can distinguish different colors and different light rays, and then the vision and the image are converted into nerve signals to be transmitted to the brain.

The visual fatigue is caused by the symptoms of blurred vision, dry eyes, eyeball soreness and the like caused by excessive use of eyes. The reason for its formation is two: one is that the eyeball is in a search fixation state for a long time, and the extraocular and ciliary muscles are metabolized more, resulting in increased accumulation of metabolic waste products (including oxygen radicals), thereby causing structural damage and functional decline of myocytes. Secondly, the visual red element is decomposed during the visual fatigue, the visual cells are excessively consumed, and the required nutrients are insufficient, so that the visual function recovery time is longer.

Myopia of teenagers is caused by poor eye use habits, such as long-time writing and reading books with heads lowered or reading electronic products, the eyes are not rested, and the axis of the eyes is in a stretched state for a long time. In the past, the axial myopia can not be caused due to the fact that the length of the axis of the eye cannot be recovered to be normal, the incidence rate of juvenile myopia is on a trend of being higher and higher, and the axial myopia becomes a health problem which draws social attention.

The existing products specially designed for eye health care of teenagers are few, or the pure medicines have strict limitation and cannot be used for a long time, or the efficacy is not good enough. Therefore, there is a need to develop an eye health product with good eye health effect suitable for teenagers.

Disclosure of Invention

The invention aims to provide a composition for eye health care of teenagers, all raw materials are medicinal and edible components, are natural and safe, can relieve visual fatigue, effectively improve the conditions of myopia at the early stage and myopia distance vision of the teenagers in the period of easy induction of myopia, and eliminate the symptoms of blurred vision, eyeball swelling, ophthalmalgia, photophobia, dry eye, eyeball soreness and tiredness and the like caused by the visual fatigue, and simultaneously has the effects of clearing heat and removing toxicity, nourishing liver and improving eyesight.

The technical scheme adopted by the invention for solving the technical problems is as follows:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30 parts of cassia seed or cassia seed extract, 20-30 parts of cowberry or cowberry extract, 10-20 parts of dogwood or dogwood extract, 20-30 parts of honeysuckle or honeysuckle extract, 5-10 parts of pawpaw or pawpaw extract and 10-20 parts of honey; or the composition comprises the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30 parts of cassia seed or cassia seed extract, 20-30 parts of cowberry or cowberry extract, 10-20 parts of dogwood or dogwood extract, 20-30 parts of honeysuckle or honeysuckle extract and 5-10 parts of pawpaw or pawpaw extract.

According to the traditional theory of traditional Chinese medicine and modern medical research, raw materials selected by the formula are all medicinal and edible substances in the 'medicinal and edible catalogue complete' published by State administration of health supervision and administration and State market administration, and the health food has the characteristics of definite and mild medicinal properties, long history, safety and reliability in eating and no toxic or side effect.

Under the guidance of the traditional Chinese medicine theory, through the reasonable proportion and the synergistic effect of the medicinal materials, the invention relieves the visual fatigue, can effectively improve the visual fatigue in the myopia susceptible period, the early myopia and the myopia distance vision conditions, eliminates the symptoms of blurred vision, eyeball fullness, ophthalmalgia, photophobia, dry eye, eyeball tiredness and the like caused by the visual fatigue, and simultaneously has the effects of clearing heat and removing toxicity, nourishing the liver and improving eyesight.

The invention can adjust the yellow spot function of human eyes, promote the increase of the microcirculation blood flow of the eyeground, accelerate the metabolism exchange of substances, enhance the protection effect on capillaries, promote the regeneration of the rhodopsin of retinal rod cells, and achieve the effects of protecting the vision and eliminating the asthenopia. The anthocyanin substance in the formula of the invention can protect the function of the corneal stroma. Can promote tear secretion, moisten eyes, maintain the stability of tear film and has obvious effect of treating xerophthalmia. The invention can inhibit MMP-2 protein expression and slow down Collagenl degradation, thereby inhibiting myopia formation. Can eliminate oxygen free radical in vivo, effectively resist oxidation, and protect tissue cells. The invention has effective protection effect on retinal photo-damage and simultaneously has obvious repair effect on the damaged retina.

Raspberry has the efficacy of nourishing liver and improving eyesight in traditional Chinese medicine, and is commonly used for dim eyesight, nourishing liver and kidney, improving eyesight and improving dim eyesight. Flavonoids, anthocyanins, ellagic acid, salicylic acid, and vitamins as main active ingredients. The flavonoids, tea polyphenols, amino acids, proteins, vitamins, and minerals in Rubi fructus have effects of enhancing immunity, resisting oxidation, and protecting liver and eyes. The book of compendium of materia medica records that the raspberry is smashed and taken to be juice, dripped into eyes, red skin is removed, and tears are eliminated. The raspberry is rich in anthocyanin, has the effect of remarkably enhancing the immunity of a human body, and has remarkable curative effect on ophthalmic diseases. The trace elements contained in Rubi fructus contain the highest content of copper and zinc. Modern medical research proves that: zinc deficiency can lead to vision loss, night vision difficulty, and phenomena such as myopia, hyperopia, astigmatism, etc. Zinc participates in metabolism and physiological function of vitamin A in human body, and has good effects of maintaining normal dark adaptation ability and improving low eyesight.

The main components of the cowberry fruit comprise anthocyanin, flavonoid, anthocyanin, rhodopsin and the like, and the fruit contains high amino acid, high zinc, high ferrum, high vitamins and the like. Anthocyanidin has strong oxidation resistance, can inhibit enzyme capable of destroying eyeball cells, remove free radical capable of damaging ocular blood vessel, and can be used for preventing various ocular diseases. Can be used for treating glaucoma and cataract. Can increase flexibility of eye capillary vessel, and can promote blood vessel expansion and flexibility. Anthocyanidin can promote rhodopsin regeneration in retina cell, and is helpful for preventing eye diseases such as macular degeneration and cataract, and improving myopia and preventing asthenopia. (ii) a Rhodopsin is the most basic substance of the eye that produces vision and enhances the sensitivity of adaptation to darkness and low light. The human eye is a highly delicate organ, the capillaries of which are most vulnerable to damage. The flavonoid has vitamin P activity, and is the best material for protecting blood vessel. High amino acid, high zinc, high ferrum and high vitamins can provide comprehensive nutrition supply for eyes.

The cassia seed has the functions of clearing liver and tonifying kidney, improving eyesight, red and swollen eyes, photophobia, lacrimation, dim sight and other symptoms in the traditional Chinese medicine theory. The record of Shen nong Ben Cao Jing records that the Chinese herbal medicine is salty, mild and nontoxic in taste. It can be used for treating glaucoma, eye diseases, conjunctival congestion, and dacryorrhea. The Chinese pharmacopoeia records: has the effects of clearing heat, improving eyesight, conjunctival congestion, headache, vertigo, dim eyesight, etc. The semen Cassiae contains physcion, emodin, obtusin, chrysophanol, and obtusin, and is rich in iron, zinc, and copper.

The Corni fructus mainly comprises polysaccharide, organic acid, flavone, anthraquinone, saponin, tannin, protein, amino acids, vitamins, etc. The Shen nong Ben Cao Jing (Shen nong's herbal channel) classifies it as the liver and kidney channels, and has the functions of enriching blood and securing essence, tonifying liver and kidney and improving eyesight in traditional Chinese medicine. It is rich in vitamin A and vitamin C, and can be used for preventing nyctalopia, xerophthalmia and cataract.

Pawpaw (chaenomeles speciosa and chaenomeles speciosa) recorded in Yu mandshui (Jade mountain ash Yao Ji) (pungent, astringent and slightly cold in flavor); ben Cao Jing Shu (Ben Cao Jing Shu) enters foot Taiyin, Yangming and foot jueyin meridians; the pawpaw entering spleen, lung, liver and kidney in the materia Medica is rich in nutrient components such as organic acid, triterpenes, saponins, saccharides, tannin, flavone, vitamin, carotene, amino acid and the like, and substances such as zinc, iron, manganese and the like. The theory of traditional Chinese medicine considers that the eye mask has the effects of relaxing muscles and tendons, promoting blood circulation, dredging collaterals, dispelling wind and removing dampness, and the formula is used for improving the function of eye blood vessels.

Honeysuckle flower recorded in famous medical records "being sweet in nature and warm in flavor, and treating cold and heat swelling, being the top grade"; ben Cao gang mu (compendium of materia Medica) for the same functions of stem leaves and flowers, which will be called the essential herb for dispelling toxicity and relieving swelling in the later generations; in this meridian source, "jin Yin Hua is the holy drug for treating dysentery with purulent blood, toxicity and pus, abscess, deep-rooted carbuncle and ulceration". The main chemical components of the honeysuckle flower comprise organic acids, volatile oil, flavonoid, iridoid, triterpenoid saponin and inorganic substances. Modern medicine researches that honeysuckle has the functions of resisting virus, resisting bacteria, relieving fever and resisting inflammation. The formula has the effects of clearing heat and removing toxicity, sterilizing and diminishing inflammation, and has the effects of sterilizing, eliminating inflammation and diminishing various bacterial infections of eyes.

The honey is used as a guide of the traditional Chinese medicines, has the effects of tonifying qi and strengthening middle-jiao, relieving pain and removing toxicity, and has the effects of regulating the flow of the traditional Chinese medicines, improving the eyesight and the ears, treating red and obstructed vision of eyes and skin, and also has the functions of resisting bacteria, enhancing the immunity, protecting the liver and strengthening the heart, relieving cough and moistening the lung, and nourishing and strengthening the body. The honey in the formula is used for relieving pain and detoxifying, mixing with the traditional Chinese medicines, improving the eyesight and the ears, treating red eyes and skin obstacles, harmonizing the medicines and adjusting the taste and the mouthfeel of the product.

Preferably, the composition for eye health care is prepared into capsules, tablets, oral liquid, drops or granules.

An oral liquid for teenager eye health care is prepared by the following method:

(1) the raw material ratio is as follows: the raspberry health care wine comprises, by weight, 20-30 parts of raspberry, 20-30 parts of cassia seed, 20-30 parts of cowberry fruit, 10-20 parts of dogwood, 20-30 parts of honeysuckle, 5-10 parts of pawpaw and 10-20 parts of honey;

(2) cleaning raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw, adding the cleaned raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw into a stainless steel pot, adding warm water into the stainless steel pot, soaking for 2-3 hours, heating until liquid in the stainless steel pot begins to boil, keeping the heating temperature at 100-120 ℃ for 20-30 minutes, and then keeping the heating temperature at 70-80 ℃ for 2-3 hours;

(3) filtering to remove residue, heating at 50-60 deg.C for 5-8 hr while adding Mel, stirring, naturally cooling to room temperature, packaging, and sterilizing.

Preferably, the warm water temperature is 40-60 deg.C, and the amount of warm water is 3-5L per kg of mixture of Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis.

Eye drops for eye health care of teenagers are prepared by the following method:

(1) the raw material ratio is as follows: the raspberry health-care tea comprises, by weight, 20-30 parts of raspberry, 20-30 parts of cassia seed, 20-30 parts of cowberry fruit, 10-20 parts of dogwood, 20-30 parts of honeysuckle and 5-10 parts of pawpaw;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, soaking in water for 1-2 hr;

(3) adding water into the mixture of raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw, heating and refluxing for 2-3 times;

(4) filtering, mixing filtrates, concentrating under reduced pressure, adding ethanol under stirring until ethanol content reaches 80-85%, standing for 24-48 hr, filtering, collecting precipitate, adding water for injection and first-stage needle activated carbon, boiling under stirring for 30-40 min, naturally cooling, refrigerating at 4 deg.C, and standing for 24 hr;

(5) adjusting pH to 6.5-7, filtering with microporous membrane, sterilizing the filtrate, and packaging.

Preferably, in the step (3), the amount of water is 8-10L per kg of the mixture of raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle flower and pawpaw.

Preferably, in step (3), the extraction is performed under heating and refluxing for 2 to 3 hours each time.

Preferably, in step (4), the mixture is concentrated under reduced pressure at 80-85 ℃ to a relative density of 1.08-1.10 (measured at 60 ℃).

Preferably, in the step (4), the amount of the water for injection is 3-5L per kilogram of the precipitate, and the amount of the activated carbon for the first-level needle is 0.1-0.3% of the weight of the precipitate.

A juvenile eye health capsule is prepared by one of the following methods:

the method comprises the following steps:

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, oven drying, micronizing respectively, mixing at a certain proportion, and encapsulating into empty capsule with each capsule filled 0.3-0.5 g;

the second method comprises the following steps:

(1) the raw material ratio is as follows: 20-30 parts of raspberry extract, 20-30 parts of cassia seed extract, 20-30 parts of cowberry fruit extract, 10-20 parts of dogwood fruit extract, 20-30 parts of honeysuckle extract and 5-10 parts of pawpaw extract;

(2) uniformly mixing the raspberry extract, the cassia seed extract, the cowberry fruit extract, the dogwood fruit extract, the honeysuckle extract and the pawpaw extract according to a proportion to obtain a mixture, mixing the mixture with medicinal starch according to a ratio of 1: 5-10 weight ratio, and filling into hollow capsules, wherein each capsule is filled with 0.3-0.5 g.

Extraction process of raspberry extract

1. Taking 1000g of fresh raspberry fruit, carrying out vacuum freeze drying to constant weight, and crushing. Screening with 65 mesh sieve, and storing at low temperature. 2. Weighing 500g of raspberry dry powder in a container, adding 1000g of ethanol water solution (80-85%), placing in an ultrasonic cell machine for extraction for 15-30 min, and centrifuging at the normal temperature of 3000r/min for min. 3. Filtering, and collecting supernatant. 4. And (4) concentrating in vacuum. 5. Vacuum drying to obtain Rubi fructus extract.

Second, extraction process of cowberry fruit extract

1. Fresh cowberry fruit, removing rotten and immature fruit, cleaning with distilled water, and air drying to remove surface water. 2. Pulverizing with pulverizer to obtain cowberry fruit pulp. 3. Conveying the cowberry fruit pulp to an extraction tank for extraction through a circulating vacuum pump. 4. According to the material-liquid ratio of 1: 10 g/ml, delivering acidified ethanol extractant (60%) with pH of 3.0 to ethanol leaching tank, opening stirring paddle, adjusting rotation speed to 140r/min, opening jacketed heat exchanger steam valve, heating to 50 deg.C, and leaching for 3 hr. 5. Centrifuging the leaching solution in a high speed centrifuge at 4000r/min for 1h, removing residues, and extracting supernatant. 6. Spray drying the supernatant to obtain cowberry fruit powder extract.

Extraction process of extract of cornus officinalis

1. Oven drying Corni fructus (5000 g) in 50 deg.C oven for 24 hr, pulverizing, and sieving. 2. 1000g of dogwood powder is extracted by 2 times (g: ml) of petroleum ether (30-60 ℃) for 24 hours, and then degreasing and air drying are carried out. 3. Adding 6 times (g: ml) of 80% ethanol, and soaking for 4 hr. 4. Recovering ethanol under reduced pressure. 5. Adding 2000g of 1% hydrochloric acid until no precipitate is generated, centrifuging for 10-15 minutes, and filtering. 6. Adjusting the pH of the filtrate to 8-9.5 by using concentrated ammonia water, centrifuging, collecting precipitate, and drying to obtain the dogwood extract.

Extraction process of extracts of four pawpaw and pawpaw

1. And blanching the whole fresh pawpaw fruits for 10-15 minutes by boiling water at 100 ℃, and taking out and then cooling. 2. Slicing the blanched and air-cooled pawpaw into slices of 0.3-0.5 cm by using a slicing machine, and drying at the temperature of 80 ℃ in a drying room for 24 hours. 3. The pulverizer pulverizes into 40-mesh powder. 4. Weighing 500g of pawpaw powder, and mixing the raw materials in a proportion of 1: adding 80% ethanol into the mixture at 25 (g: ml) times of the ratio of the materials to the liquid, and extracting for 3-4 h at 80-90 ℃. 5. Cooling and filtering. 6. Recovering ethanol from the filtrate under reduced pressure. 7. Vacuum drying to obtain fructus Chaenomelis extract.

Extraction process of honeysuckle flower extract

1. 1000g of honeysuckle, drying for 3 hours at 80 ℃ in a dryer, crushing, sieving with a 20-mesh sieve, and storing in a dryer for later use. 2. 500g of honeysuckle powder is taken and 5000ml of 65 percent ethanol with pH value of 3 is added. 3. Extracting under reflux at 90 deg.C for 1 hr for 2 times. 4. And (5) filtering. 5. Distilling under reduced pressure at 60 deg.C to recover ethanol, and vacuum drying to obtain flos Lonicerae extract.

Extraction process of cassia seed extract

1. The mixture is crushed according to 500g of the cassia seeds and is sieved by a 120-mesh sieve. 2. According to the material-liquid ratio of 1: 80% ethanol was added to 8 (g: ml) and the mixture was soaked overnight. 3. Heating and reflux extracting for 120min for 2 times. 4. Filtering, and recovering ethanol under reduced pressure. 5. Vacuum drying to obtain semen Cassiae extract.

The invention has the beneficial effects that: all the raw materials are medicinal and edible components, are natural and safe, can relieve visual fatigue, effectively improve the near-sightedness period, early near-sightedness and far-sightedness conditions of teenagers, eliminate the symptoms of blurred vision, eyeball swelling, ophthalmalgia, photophobia, dry eye, eyeball tiredness and the like caused by the visual fatigue, and simultaneously have the effects of clearing heat and removing toxicity, nourishing liver and improving eyesight.

Detailed Description

The technical solution of the present invention will be further specifically described below by way of specific examples.

In the present invention, the raw materials and equipment used are commercially available or commonly used in the art, unless otherwise specified. The methods in the following examples are conventional in the art unless otherwise specified.

Example 1:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 20 parts of raspberry, 20 parts of cassia seed, 20 parts of cowberry fruit, 10 parts of dogwood, 20 parts of honeysuckle, 5 parts of pawpaw and 10 parts of honey.

Example 2:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 30 parts of raspberry, 30 parts of cassia seed, 30 parts of cowberry fruit, 20 parts of dogwood, 30 parts of honeysuckle, 10 parts of pawpaw and 20 parts of honey.

Example 3:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 25 parts of raspberry, 25 parts of cassia seed, 25 parts of cowberry fruit, 15 parts of dogwood, 25 parts of honeysuckle, 8 parts of pawpaw and 15 parts of honey.

Example 4:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 20 parts of raspberry, 20 parts of cassia seed, 20 parts of cowberry fruit, 10 parts of dogwood, 20 parts of honeysuckle and 5 parts of pawpaw.

Example 5:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 30 parts of raspberry, 30 parts of cassia seed, 30 parts of cowberry fruit, 20 parts of dogwood, 30 parts of honeysuckle and 10 parts of pawpaw.

Example 6:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: 25 parts of raspberry, 25 parts of cassia seed, 25 parts of cowberry fruit, 15 parts of dogwood, 25 parts of honeysuckle and 8 parts of pawpaw.

Example 7:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: the composition comprises the following raw materials in parts by weight: 20 parts of raspberry extract, 20 parts of cassia seed extract, 20 parts of cowberry fruit extract, 10 parts of dogwood fruit extract, 20 parts of honeysuckle extract and 5 parts of pawpaw extract.

Example 8:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: the composition comprises the following raw materials in parts by weight: 30 parts of raspberry extract, 30 parts of cassia seed extract, 30 parts of cowberry fruit extract, 20 parts of dogwood fruit extract, 30 parts of honeysuckle extract and 10 parts of pawpaw extract.

Example 9:

the composition for eye health care of teenagers comprises the following raw materials in parts by weight: the composition comprises the following raw materials in parts by weight: 25 parts of raspberry extract, 25 parts of cassia seed extract, 25 parts of cowberry fruit extract, 15 parts of dogwood fruit extract, 25 parts of honeysuckle extract and 8 parts of pawpaw extract.

Example 10:

(1) the raw material ratio is as follows: the same as example 1;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, adding into stainless steel pot, adding warm water, soaking for 2 hr, heating until the liquid in the stainless steel pot begins to boil, maintaining at 100 deg.C for 30min, and maintaining at 70 deg.C for 3 hr; the temperature of the warm water is 60 ℃, and the amount of the warm water is 3L per kg of the mixture of the raspberry, the cassia seed, the cowberry fruit, the dogwood, the honeysuckle and the pawpaw;

(3) filtering to remove residue, heating at 50 deg.C for 8 hr while adding Mel and stirring, naturally cooling to room temperature, bottling, and sterilizing.

Example 11:

(1) the raw material ratio is as follows: the same as example 2;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, adding into stainless steel pot, adding warm water, soaking for 3 hr, heating until the liquid in the stainless steel pot begins to boil, maintaining at 120 deg.C for 20min, and maintaining at 80 deg.C for 2 hr; the temperature of the warm water is 40 ℃, and the amount of the warm water is 5L per kg of the mixture of the raspberry, the cassia seed, the cowberry fruit, the dogwood, the honeysuckle and the pawpaw;

(3) filtering to remove residue, heating at 60 deg.C for 5 hr while adding Mel, stirring, naturally cooling to room temperature, bottling, and sterilizing.

Example 12:

(1) the raw material ratio is as follows: the same as in example 3;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, adding into stainless steel pot, adding warm water, soaking for 2.5 hr, heating until the liquid in the stainless steel pot begins to boil, maintaining at 110 deg.C for 25 min, and maintaining at 75 deg.C for 2.5 hr; the temperature of the warm water is 50 ℃, and the amount of the warm water is 4L per kg of the mixture of the raspberry, the cassia seed, the cowberry fruit, the dogwood, the honeysuckle and the pawpaw;

(3) filtering to remove residue, heating at 55 deg.C for 6 hr while adding Mel and stirring, naturally cooling to room temperature, bottling, and sterilizing.

Example 13:

(1) the raw material ratio is as follows: the same as example 4;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, soaking in water for 1 hr;

(3) adding water into the mixture of raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw, heating, refluxing and extracting for 2 times, and heating, refluxing and extracting for 3 hours each time; the amount of water is 8L per kg of mixture of Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis;

(4) filtering, mixing filtrates, concentrating at 80 deg.C under reduced pressure to relative density of 1.08-1.10, adding ethanol under stirring until ethanol content reaches 80%, standing for 48 hr, filtering, collecting precipitate, adding water for injection and first-stage needle activated carbon, boiling under stirring, maintaining for 30min, naturally cooling, refrigerating at 4 deg.C, and standing for 24 hr; the dosage of water for injection is 3L per kilogram of precipitate, and the dosage of activated carbon for the first-level needle is 0.1 percent of the weight of the precipitate;

Example 14:

(1) the raw material ratio is as follows: the same as example 5;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, soaking in water for 2 hr;

(3) adding water into the mixture of raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw, heating, refluxing and extracting for 3 times, and heating, refluxing and extracting for 2 hours each time; the amount of water is 10L per kg of mixture of Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis;

(4) filtering, mixing filtrates, concentrating at 85 deg.C under reduced pressure to relative density of 1.08-1.10, adding ethanol under stirring until ethanol content reaches 85%, standing for 24 hr, filtering, collecting precipitate, adding water for injection and first-stage needle activated carbon, boiling under stirring, maintaining for 40 min, naturally cooling, refrigerating at 4 deg.C, and standing for 24 hr; the dosage of water for injection is 5L per kilogram of precipitate, and the dosage of activated carbon for the first-level needle is 0.3 percent of the weight of the precipitate;

Example 15:

(1) the raw material ratio is as follows: the same as in example 6;

(2) cleaning Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis, soaking in water for 1.5 hr;

(3) adding water into the mixture of raspberry, cassia seed, cowberry fruit, dogwood, honeysuckle and pawpaw, heating, refluxing and extracting for 3 times, and heating, refluxing and extracting for 2.5 hours each time; the amount of water is 9L per kg of mixture of Rubi fructus, semen Cassiae, cowberry fruit, Corni fructus, flos Lonicerae and fructus Chaenomelis;

(4) filtering, mixing filtrates, concentrating under reduced pressure at 82 deg.C to relative density of 1.08-1.10, adding ethanol under stirring until ethanol content reaches 80%, standing for 30 hr, filtering, collecting precipitate, adding water for injection and first-stage needle activated carbon, boiling under stirring, maintaining for 35 min, naturally cooling, refrigerating at 4 deg.C, and standing for 24 hr; the dosage of water for injection is 4L per kilogram of precipitate, and the dosage of activated carbon for the first-level needle is 0.2 percent of the weight of the precipitate;

Example 16:

a juvenile eye health capsule is prepared by the following method:

(1) the raw material ratio is as follows: one of examples 4 to 6;

example 17:

a juvenile eye health capsule is prepared by the following method:

(1) the raw material ratio is as follows: one of examples 7 to 9;

The oral liquid of example 12 was used as an example for the test, and the test results were as follows:

first, the test subject is 163 teenagers voluntarily participating in Hangzhou city, and the time is 11 months in 2019 to 7 months in 2020. The control group and the treatment group were randomly divided. Wherein, the control group comprises 47 people, wherein 24 men and 23 women are 10-25 years old, and the average age is 18.5 years old; the treatment group comprises 115 people, 60 men and 56 women, the age is 10-25 years, and the average age is 18.1 years.

II, selecting conditions: the single-eye or double-eye vision is detected by a logarithmic visual acuity chart to be less than 5.0; the computer optometry diopter is between-0.5D and-3.0D after the rapid mydriasis; checking outer eye and refraction medium by slit lamp, direct ophthalmoscopic detection, and eliminating organic diseases of eye and amblyopia patient; and eliminating systemic diseases and hereditary myopia.

Thirdly, an experimental method: treatment groups: the oral liquid is taken orally for 100 mg/time and 2 times a day; control group: maltose syrup is orally administered at a dose of 100 mg/time, 2 times daily. 1 month is 1 course of treatment and the test method is double blind.

Fourthly, a detection method: all subjects underwent visual acuity, slit-lamp, ophthalmoscope, rapid mydriasis computer optometry, and other tests prior to the experiment. After a course of treatment, the above examinations are repeated. Eye symptoms were registered before and after all subjects took the drug, and classified into none (score 0), light (score 1), medium (score 2) and heavy (score 3), and counted as an integrated value.

Fifthly, judging the standard:

(I) symptom improvement: (1) the score is 0 after taking; (2) the integral is found before and after taking, but the integral before taking minus the integral after taking is more than or equal to 1.

And (4) invalidation: (1) the score is the same before and after taking; (2) the score after taking is larger than that before taking.

And vision: improvement (increase): the vision after taking is improved by 2 lines or more than before taking by checking the logarithmic visual chart.

And (4) invalidation: after taking the medicine, the vision is not improved or improved by less than 2 lines compared with the vision before taking the medicine.

Diopter: the improvement is as follows: computer optometry is carried out after rapid mydriasis, and the dose is reduced by 0.5D or more after administration compared with that before administration.

Sixthly, counting results: symptoms are: the symptoms are improved before and after administration by counting with integral, the average of two groups of samples is compared by t test, and the symptom improvement rate is X²And (6) checking. Eyesight: the vision before and after taking is counted by 5 scores of the logarithmic visual chart, the average of the two groups of samples is compared by t test, and the vision improvement rate is X²And (6) checking. Diopter: before and after taking the medicine, the diopters are compared by using a t test.

Results of the experiment

1. Symptom integration method, t test before and after administration, and control group P>0.05; treatment group P<0.05; comparison of symptom improvement Rate X²Test, control group P>0.5, the difference is not significant; treatment group<The difference of 0.05 is significant (see tables 1 and 2).

TABLE 1 improvement of major ocular symptoms after administration

Note: the corresponding numbers in the parentheses are the corresponding numbers in the control group; p-value is the ratio of improvement in symptoms after administration of the treatment group compared to the control group.

TABLE 2 before and after administration two groups of clinical symptom score statistics

Note: the comparison P of the treated group to the control group after administration was < 0.05.

2. Eyesight: the vision of the control group is improved by less than 2 lines before and after the control group is taken, and the difference is not significant because P is more than 0.5 in t test. The mean visual acuity before and after the treatment group is taken is improved by more than 2 lines, and the difference is obvious when the P is less than 0.05 in t test (see tables 3 and 4).

3. Diopter: the difference is not significant when the P is greater than 0.05 by t test before and after the control group or the treatment group takes the medicine.

TABLE 3 comparison of the change in eyesight before and after administration of the two groups

TABLE 4 comparison of the improved Vision of the two groups after administration

Conclusion

The study discusses the influence of the oral liquid on visual fatigue and eyesight, and the study adopts a double-blind method to carry out preliminary study on teenagers of 10-25 years old. The result indicates that (1) the invention can effectively relieve or eliminate the symptoms of blurred vision, eyeball swelling, eye pain, photophobia, dry eye, eyeball tiredness and the like caused by visual fatigue. (2) The invention can effectively improve the visual conditions of myopia at the susceptible stage, early myopia and mild myopia, and the effective rate reaches 77.39 percent (P is less than 0.05).

Eye drop experiment of the present invention

Case selection criteria: the teenagers aged 10-25 years are mostly used for eyes in daily life. The symptoms mainly include 160 cases (320 eyes) of eye fatigue, dryness, burning sensation, eye itching, discomfort, visual fluctuation, foreign body sensation and the like, and the treatment group is divided into 80 cases (160 eyes) and the control group is divided into 80 cases (160 eyes) at random. The treatment group was eye drops of the present invention (example 15), and the control group was water for injection, in a double-blind manner.

The treatment group drops the formula eye drops for 2-3 times per day in two eyes, and 1 drop is dropped in each eye each time; the control group was administered with 1 drop per eye 2-3 times a day. The experimental time was 3 weeks (21 days).

Comparison of therapeutic effects after treatment (n%)

Safety: there were no adverse reactions during both treatment periods.

The eye drop has eye health care effect obviously superior to that of a control group, and the total effective rate is up to 96%.

The capsule test of the invention (example 17 capsules, formulation example 9, mixture and pharmaceutical starch in a weight ratio of 1: 8, 0.3g per capsule):

case (2):

yu-jiao, male, 25 years old, and a certain residential quarter of Hangzhou archway. The self-described work causes the computer to be faced for a long time. Eye swelling and pain, and vision decline in the last four years, and no effect is seen after various eye drops are used. The capsule of the invention is taken for more than one month, 2 times a day, 3 capsules each time. The eyes feel no more swelling and pain, and the vision is obviously improved.

A certain woman in the week, age 19, lived in a certain cell in Hangzhou Binjiang. The vision is seriously degraded after long-term study every day. The eyes are dry and uncomfortable after long-time use of the eye drops. The capsule of the invention is taken for 2 months, 2 times a day, 3 capsules each time. The eyes are comfortable, and the vision is obviously improved.

A certain square, male, 15 years old, lived in a certain community in the province of Hangzhou Qiandao lake town. After entering the junior middle school, serious vision decline, dry eyes, blurred vision and photophobia are aggravated along with the study task, and the hospital treatment medicine taking has no obvious effect. After the capsule is taken for one month and a half, 2 times a day, 4 capsules each time, the dry eye phenomenon disappears, photophobia is avoided, and the vision is obviously improved.

When a man is in 10 years old and stays in a certain district of the Hangzhou sand economy development area, the vision is seriously degraded in recent years, and a hospital can see a doctor for many times. After the capsule of the invention is taken for 2 months and 2 times a day, 3 capsules are taken each time, the vision is obviously improved, the hyperopia is obviously improved, and the contents of teachers writing on blackboard can be clearly seen by sitting behind the seat.

A certain abalone, a woman, 12 years old, lives in a certain cell in Hangzhou West lake region. The left eye and the right eye of the eye are both 300 degrees myopia and astigmatism, and have a deepening trend. After the capsule of the invention is taken for 2 more months, 2 times a day and 3 capsules each time, the subjective vision is not blurred any more, the eyes are more comfortable than before, and the vision is obviously improved.

Liao A woman in 24 years old stays in a Hangzhou district. Since the last year, the study time is sixteen or more hours and seven hours each day for the preparation of graduation papers and research works. Dizziness, blurred vision, ophthalmalgia, photophobia, dry eyes, eyeball tiredness, insomnia, memory decline and other symptoms appear in the last half of the year, and the diagnosis and treatment effect in hospitals is not ideal. After the capsule of the invention is taken for three months, 2 times a day and 3 capsules each time, the phenomenon disappears, and the insomnia and the memory are obviously improved.

Zheng for a male, 22 years old, and lived in a certain cell in Hangzhou. The dependence of electronic products such as mobile phones and computers is strong. Serious vision decline, eye fatigue, pain, eye dryness, lacrimation, photophobia and poor hospital treatment effect. After the capsule of the invention is taken for more than one month, 2 times a day, 4 capsules each time, the phenomena of pain, dryness, lacrimation and photophobia disappear, the fatigue is obviously improved, and the vision is obviously improved.

Some, women, age 16, lived in some community in the thousand island lake. Parents reflect the importance of academic, have more jobs, and study time reaches 15 to 6 hours every day. The eye fatigue, the eye pain, the eye dryness, the headache, the insomnia and the unobvious diagnosis and treatment effect in the hospital. After the capsule is taken for 2 months and 2 times a day, 3 capsules are taken each time, eye fatigue and pain symptoms disappear, eyes are not dry and astringent, headache and insomnia are obviously improved, and vision is obviously improved.

The above-described embodiments are only preferred embodiments of the present invention, and are not intended to limit the present invention in any way, and other variations and modifications may be made without departing from the spirit of the invention as set forth in the claims.

Claims

1. The composition for eye health care of teenagers is characterized by comprising the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30 parts of cassia seed or cassia seed extract, 20-30 parts of cowberry or cowberry extract, 10-20 parts of dogwood or dogwood extract, 20-30 parts of honeysuckle or honeysuckle extract, 5-10 parts of pawpaw or pawpaw extract and 10-20 parts of honey;

or the composition comprises the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30 parts of cassia seed or cassia seed extract, 20-30 parts of cowberry or cowberry extract, 10-20 parts of dogwood or dogwood extract, 20-30 parts of honeysuckle or honeysuckle extract and 5-10 parts of pawpaw or pawpaw extract.

2. The composition for eye health care of teenagers as claimed in claim 1, wherein the composition for eye health care is formulated into capsule, tablet, oral liquid, drop or granule.

3. An oral liquid for juvenile eye health care is characterized by being prepared by the following method:

4. The oral liquid for teenager eye health care according to claim 3, wherein the warm water temperature is 40-60 ℃, and the amount of warm water is 3-5L per kg of mixture of Rubi fructus, Cassia Torae semen, Vaccinium myrtillus, Corni fructus, Lonicera Japonica flos and fructus Chaenomelis.

5. An eye drop for eye health care of teenagers is characterized by being prepared by the following method:

6. The eye drop for eye health care of teenagers as claimed in claim 1, wherein in the step (3), the amount of water is 8-10L per kg of the mixture of Rubi fructus, Cassia Torae semen, Vaccinium Vitis-idaeae, Corni fructus, Lonicera Japonica flos and Chaenomeles fructus.

7. The ophthalmic solution for eye health care in teenagers as claimed in claim 1, wherein in step (3), the extraction is performed by heating under reflux for 2-3 hours each time.

8. The eye drop for juvenile eye health according to claim 1, wherein in the step (4), the eye drop is concentrated under reduced pressure at 80-85 ℃ to a relative density of 1.08-1.10.

9. The eye drops for health care of eyes of teenagers as claimed in claim 1, wherein in step (4), the amount of water for injection is 3-5L per kg of the precipitate, and the amount of activated carbon for the primary injection is 0.1-0.3% of the precipitate.

10. A capsule for eye health care of teenagers is characterized by being prepared by one of the following methods:

the method comprises the following steps:

the second method comprises the following steps: