CN111999784A - Use of polymers as substrates for biochips - Google Patents
Use of polymers as substrates for biochips Download PDFInfo
- Publication number
- CN111999784A CN111999784A CN202010930662.4A CN202010930662A CN111999784A CN 111999784 A CN111999784 A CN 111999784A CN 202010930662 A CN202010930662 A CN 202010930662A CN 111999784 A CN111999784 A CN 111999784A
- Authority
- CN
- China
- Prior art keywords
- substrate
- polymer
- optical waveguide
- use according
- pmma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000758 substrate Substances 0.000 title claims abstract description 34
- 229920000642 polymer Polymers 0.000 title claims abstract description 26
- 238000000018 DNA microarray Methods 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 22
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims abstract description 19
- 239000002861 polymer material Substances 0.000 claims abstract description 7
- 230000003287 optical effect Effects 0.000 claims description 33
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 17
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 17
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 5
- 239000011521 glass Substances 0.000 abstract description 19
- 238000004519 manufacturing process Methods 0.000 abstract description 13
- 239000004417 polycarbonate Substances 0.000 description 9
- 229920000515 polycarbonate Polymers 0.000 description 9
- 239000004793 Polystyrene Substances 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 238000001338 self-assembly Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920000307 polymer substrate Polymers 0.000 description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/045—Light guides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B6/122—Basic optical elements, e.g. light-guiding paths
- G02B6/1226—Basic optical elements, e.g. light-guiding paths involving surface plasmon interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B2006/12035—Materials
- G02B2006/12069—Organic material
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optical Integrated Circuits (AREA)
Abstract
The invention discloses an application of a polymer as a substrate of a local surface plasmon resonance biochip. The polymer material is used as the substrate of the localized surface plasmon resonance biochip instead of the existing glass material, so that the manufacturing cost can be reduced, the structure is firm, the structure is easy to construct, the rapid forming is realized, and the requirement of large-scale manufacturing is met.
Description
Technical Field
The present invention relates to the field of biochips, in particular to the field of the application of polymers as substrates for localized surface plasmon resonance biochips.
Background
An advanced version of nanotechnology based technology, called Localized Surface Plasmon Resonance (LSPR) with nanostructures, is a technology that establishes label-free biosensing. The biochip in the prior art mostly uses glass as a substrate, and has the defects of high melting point, high-temperature process, hard and fragile structure, difficult shape change, complex manufacturing process, unstable structure, difficult structure and difficult rapid forming.
Based on this, there is a strong need in the art for an alternative substrate material for localized surface plasmon resonance biochips that is not only cost-effective, structurally robust, but also easy to construct, rapidly shaped, and meets the requirements for large-scale manufacturing.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to: an alternative substrate material for localized surface plasmon resonance biochips is provided that not only reduces manufacturing costs, is structurally robust, but is also easy to construct, is rapidly shaped, and meets the requirements for large-scale manufacturing.
In order to achieve the purpose, the technical scheme of the invention is as follows:
in one aspect, the present invention provides the use of a polymer as a substrate for a localized surface plasmon resonance biochip.
In a preferred embodiment, the polymer is PMMA, PC or PS, more preferably PMMA or PC, most preferably PMMA.
In a preferred embodiment, the portions of the substrate may be composed of the same material or may be composed of different materials.
In a preferred embodiment, the localized surface plasmon resonance biochip further comprises: (1) a plurality of optical waveguides disposed in the substrate, the plurality of optical waveguides comprising an optical waveguide array; (2) titanium nitride nanocubes disposed on a side surface of each of the optical waveguides.
In a preferred embodiment, the material of the optical waveguide is at least the same as the material of the substrate portion where the optical waveguide is arranged, more preferably a PMMA or PC polymer material, most preferably a PMMA polymer material.
In a preferred embodiment, the titanium nitride nanocubes self-assemble on the surface of the optical waveguide array by chemical bonding.
The invention has the beneficial effects that:
1. the polymer material is used as the substrate of the localized surface plasmon resonance biochip instead of the existing glass material, and has the advantages of low cost, firm structure, easy construction and quick forming.
2. The polymer material is used as the substrate of the localized surface plasmon resonance biochip, can be formed at one time through 3D printing, and has the advantages of convenience in manufacturing, easiness in forming and capability of meeting the requirement of large-scale manufacturing.
3. The substrate and the optical waveguide adopt the same PMMA, PC and other polymers as composition materials, not only can realize the refractive index basically same as BK7 glass and the like, but also can be fixed on the surface of the polymer optical waveguide through chemical bond self-assembly with the titanium nitride nanocube material, thereby being convenient for manufacturing, improving the manufacturing efficiency and reducing the cost.
In conclusion, the technical scheme of the invention not only can reduce the manufacturing cost and has a firm structure, but also is easy to construct and fast to form and meets the requirement of large-scale manufacturing.
Drawings
The invention is described in further detail below with reference to the figures and examples, it being noted that the examples or embodiments described below are intended to facilitate the understanding of the invention and are not intended to be limiting.
FIG. 1 shows a structure of a glass-based biochip in the prior art.
FIG. 2 shows one embodiment of the use of the polymers of the present invention as localized surface plasmon resonance biochips.
Fig. 3 shows the arrangement of the titanium nitride nanocubes of the present invention on the side surface of a polymer optical waveguide.
Fig. 4 shows the real part (n) of the complex refractive index of the polymer compared with BK7 glass in the wavelength range of excitation light of 400nm to 1200 nm.
Fig. 5 shows the imaginary part (k) of the complex refractive index of the polymer compared to BK7 glass in the wavelength range of excitation light of 400nm to 1200 nm.
Detailed Description
As required, detailed embodiments of the present invention are disclosed herein. However, it is to be understood by those skilled in the art that the disclosed embodiments are merely exemplary of the invention, which can be embodied in various and suitable forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a basis for teaching one skilled in the art to variously employ the present invention in any appropriate arrangement, structure or system.
Referring to fig. 1, a structure of a glass-based biochip in the prior art is shown. The prior art is a 40 nanometer gold island structure which takes glass as a substrate and is grown by a high-temperature self-assembly tin shrinking method.
Referring to FIG. 2, there is shown one embodiment of the use of the polymer of the present invention as a localized surface plasmon resonance biochip. The polymer substrate for the localized surface plasmon resonance biochip of the present invention can be formed in one step by 3D printing. One skilled in the art will appreciate that the substrate may be comprised of one or more materials.
Referring to fig. 3, there is shown the arrangement of the titanium nitride nanocubes of the present invention on the side surface of the polymer optical waveguide. The optical waveguide shapes and nanocube materials shown in fig. 3 are for illustration only and not for limitation. It will be understood by those skilled in the art that the polymeric substrate of the present invention and the optical waveguide associated therewith may be of the same or different composition materials, preferably at least the substrate portion in which the optical waveguide is disposed and the optical waveguide are of the same material. It will be understood by those skilled in the art that the polymer optical waveguide or the substrate both contain chemical bonds, and the surface plasmon resonance portion of the optical waveguide can be dispersed and immobilized on the surface plasmon resonance sample detection portion of the optical waveguide by a chemical bond self-assembly method. For example, when a polymer such as PMMA, PC, etc. is used as the substrate and the optical waveguide, titanium nitride nanocubes are used as an example of the surface plasmon resonance portion of the optical waveguide, and the titanium nitride nanocubes may be dispersed and fixed on the surface plasmon resonance sample detection portion of the optical waveguide by titanium-oxygen bond self-assembly with the polymer optical waveguide.
Referring to fig. 4, the real part (n) of complex refractive index of the polymer compared to BK7 glass in the wavelength range of excitation light of 400nm to 1200nm is shown, n is an index of the propagation speed of light waves in a dielectric, n is 1 in vacuum, and the larger n represents the slower the propagation speed of light waves in the dielectric. In fig. 4 it is shown that Polymethylmethacrylate (PMMA) is close to n for BK7 glass, that for Polycarbonate (PC) and Polystyrene (PS) n is higher than for BK7 glass, and that for polydimethylsiloxane n is significantly lower than for BK7 glass. PMMA, PC and PS are preferred substrate materials to replace BK7 glass, since in localized plasmon resonance biochips it is necessary to couple evanescent waves by total internal reflection to excite plasmon resonance, and biological analytes detected by biochips usually contain water (n ═ 1.3330).
Referring to fig. 5, the imaginary part (k) of the complex index of refraction of a polymer compared to BK7 glass is shown, k being an indicator of the optical loss of light through the material, over the wavelength range of excitation light of 400nm to 1200nm, the larger k, the greater the optical loss, and vice versa. In fig. 5 it is shown that k for PC and PMMA is approximately the same as k for BK7 glass, so PMMA, PC and PS are preferred substrate materials to replace BK7 glass. Fig. 4 to 5 can confirm that the polymer substrate of the present invention can achieve substantially the same refractive index as the BK7 glass substrate.
In conclusion, when the polymer is used as the substrate of the local surface plasmon resonance biochip, the refractive index of the polymer can be the same as that of a glass substrate, and the polymer has the advantages of low cost, easiness in construction, firm structure, quickness in molding and capability of meeting the large-scale manufacturing requirement.
It is to be understood that while preferred embodiments have been described in detail hereinabove, the invention is not limited to the arrangement of materials, structures and features described and illustrated herein, which are merely exemplary of preferred embodiments of the invention, which may be embodied in various equivalent forms.
Claims (10)
1. Use of a polymer as a substrate for a biochip, characterized in that the substrate is a substrate for a localized surface plasmon resonance biochip. .
2. Use according to claim 1, wherein the polymer is PMMA, PC or PS.
3. Use according to claim 2, wherein the polymer is PMMA or PC.
4. Use according to claim 3, characterized in that the polymer is PMMA.
5. Use according to claim 1, wherein the parts of the substrate consist of the same material.
6. Use according to claim 1, wherein the parts of the substrate consist of different materials.
7. The use according to claim 1, wherein the biochip further comprises: (1) a plurality of optical waveguides disposed in the substrate, the plurality of optical waveguides comprising an optical waveguide array; (2) titanium nitride nanocubes disposed on a side surface of each of the optical waveguides.
8. Use according to claim 7, wherein the material of the optical waveguide is at least the same as the material of the substrate part where the optical waveguide is arranged, being PMMA or PC polymer material.
9. Use according to claim 8, wherein the material of the optical waveguide is at least the same as the material of the substrate part in which the optical waveguide is arranged, being a PMMA polymer material.
10. Use according to claim 7, wherein the titanium nitride nanocubes self-assemble on the surface of the optical waveguide array by chemical bonding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010930662.4A CN111999784B (en) | 2020-09-07 | 2020-09-07 | Use of polymers as substrates for biochips |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010930662.4A CN111999784B (en) | 2020-09-07 | 2020-09-07 | Use of polymers as substrates for biochips |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111999784A true CN111999784A (en) | 2020-11-27 |
| CN111999784B CN111999784B (en) | 2024-03-22 |
Family
ID=73468901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010930662.4A Active CN111999784B (en) | 2020-09-07 | 2020-09-07 | Use of polymers as substrates for biochips |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111999784B (en) |
Citations (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022475A1 (en) * | 2002-07-31 | 2004-02-05 | Luna Innovations, Inc. | Biosensors having enhanced environmental sensitivity |
| JP2005069978A (en) * | 2003-08-27 | 2005-03-17 | Toyobo Co Ltd | Biochip |
| CN101398377A (en) * | 2007-09-25 | 2009-04-01 | 北京大学 | Polymer SPR chip and method for making same |
| CN103868887A (en) * | 2014-03-11 | 2014-06-18 | 中国科学院重庆绿色智能技术研究院 | Graphene film-based tapered optical fiber sensor |
| CN104634763A (en) * | 2015-02-11 | 2015-05-20 | 浙江大学 | SPR sensor chip and preparation method thereof |
| EP3199993A1 (en) * | 2016-01-27 | 2017-08-02 | Centre National de la Recherche Scientifique (C.N.R.S.) | Optical plasmonic conductors comprising one or more fibrillar organic supramolecular species |
| KR20180028798A (en) * | 2016-09-09 | 2018-03-19 | 주식회사 엘지화학 | Glass light guide plate, backlight unit and display device including the same |
| CN107849738A (en) * | 2015-02-16 | 2018-03-27 | 密执安州立大学董事会 | System and method for carrying out immunoassays |
| US20180275343A1 (en) * | 2017-03-27 | 2018-09-27 | Board Of Regents, The University Of Texas System | Nanostructured photonic materials |
| CN109470682A (en) * | 2017-09-08 | 2019-03-15 | 清华大学 | Molecular vehicle for Molecular Detection |
| CN110087867A (en) * | 2016-12-19 | 2019-08-02 | 3M创新有限公司 | Flexible substrates and preparation method thereof with plasma particle surface covering |
| US20190324206A1 (en) * | 2017-01-20 | 2019-10-24 | Virginia Tech Intellectual Properties, Inc. | Plasmonic Nanoparticle Layers with Controlled Orientation |
| CN110764186A (en) * | 2018-07-27 | 2020-02-07 | 京东方科技集团股份有限公司 | Optical waveguide substrate and microfluidic device |
| WO2020065535A1 (en) * | 2018-09-24 | 2020-04-02 | Sabic Global Technologies B.V. | Integrated plasmons with thin film transistor (tft) device for molecular biosensing |
| CN111060466A (en) * | 2019-12-30 | 2020-04-24 | 暨南大学 | Portable optical gas sensor |
| US10725373B1 (en) * | 2016-10-21 | 2020-07-28 | Iowa State University Research Foundation, Inc. | Nano-patterning methods including: (1) patterning of nanophotonic structures at optical fiber tip for refractive index sensing and (2) plasmonic crystal incorporating graphene oxide gas sensor for detection of volatile organic compounds |
| CN112014924A (en) * | 2020-09-07 | 2020-12-01 | 科竟达生物科技有限公司 | Method for decorating nanocubes on surface of polymer optical waveguide, optical waveguide manufactured by method, biosensing system and application |
| CN112033932A (en) * | 2020-09-07 | 2020-12-04 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip, manufacturing method thereof, biosensing system comprising local surface plasmon resonance biochip and application of biosensing system |
| CN116953847A (en) * | 2023-08-02 | 2023-10-27 | 桂林电子科技大学 | Mixed surface plasma directional coupler for network on optical sheet |
-
2020
- 2020-09-07 CN CN202010930662.4A patent/CN111999784B/en active Active
Patent Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022475A1 (en) * | 2002-07-31 | 2004-02-05 | Luna Innovations, Inc. | Biosensors having enhanced environmental sensitivity |
| JP2005069978A (en) * | 2003-08-27 | 2005-03-17 | Toyobo Co Ltd | Biochip |
| CN101398377A (en) * | 2007-09-25 | 2009-04-01 | 北京大学 | Polymer SPR chip and method for making same |
| CN103868887A (en) * | 2014-03-11 | 2014-06-18 | 中国科学院重庆绿色智能技术研究院 | Graphene film-based tapered optical fiber sensor |
| CN104634763A (en) * | 2015-02-11 | 2015-05-20 | 浙江大学 | SPR sensor chip and preparation method thereof |
| CN107849738A (en) * | 2015-02-16 | 2018-03-27 | 密执安州立大学董事会 | System and method for carrying out immunoassays |
| WO2017129776A1 (en) * | 2016-01-27 | 2017-08-03 | Centre National De La Recherche Scientifique | Optical plasmonic conductors comprising one or more fibrillar organic supramolecular species |
| EP3199993A1 (en) * | 2016-01-27 | 2017-08-02 | Centre National de la Recherche Scientifique (C.N.R.S.) | Optical plasmonic conductors comprising one or more fibrillar organic supramolecular species |
| KR20180028798A (en) * | 2016-09-09 | 2018-03-19 | 주식회사 엘지화학 | Glass light guide plate, backlight unit and display device including the same |
| US10725373B1 (en) * | 2016-10-21 | 2020-07-28 | Iowa State University Research Foundation, Inc. | Nano-patterning methods including: (1) patterning of nanophotonic structures at optical fiber tip for refractive index sensing and (2) plasmonic crystal incorporating graphene oxide gas sensor for detection of volatile organic compounds |
| CN110087867A (en) * | 2016-12-19 | 2019-08-02 | 3M创新有限公司 | Flexible substrates and preparation method thereof with plasma particle surface covering |
| US20190324206A1 (en) * | 2017-01-20 | 2019-10-24 | Virginia Tech Intellectual Properties, Inc. | Plasmonic Nanoparticle Layers with Controlled Orientation |
| CN110662995A (en) * | 2017-01-20 | 2020-01-07 | 弗吉尼亚技术知识资产公司 | Plasmonic nanoparticle layers with controlled orientation |
| US20180275343A1 (en) * | 2017-03-27 | 2018-09-27 | Board Of Regents, The University Of Texas System | Nanostructured photonic materials |
| CN109470682A (en) * | 2017-09-08 | 2019-03-15 | 清华大学 | Molecular vehicle for Molecular Detection |
| CN110764186A (en) * | 2018-07-27 | 2020-02-07 | 京东方科技集团股份有限公司 | Optical waveguide substrate and microfluidic device |
| WO2020065535A1 (en) * | 2018-09-24 | 2020-04-02 | Sabic Global Technologies B.V. | Integrated plasmons with thin film transistor (tft) device for molecular biosensing |
| CN111060466A (en) * | 2019-12-30 | 2020-04-24 | 暨南大学 | Portable optical gas sensor |
| CN112014924A (en) * | 2020-09-07 | 2020-12-01 | 科竟达生物科技有限公司 | Method for decorating nanocubes on surface of polymer optical waveguide, optical waveguide manufactured by method, biosensing system and application |
| CN112033932A (en) * | 2020-09-07 | 2020-12-04 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip, manufacturing method thereof, biosensing system comprising local surface plasmon resonance biochip and application of biosensing system |
| WO2022047847A1 (en) * | 2020-09-07 | 2022-03-10 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip and manufacturing method therefor, biosensing system including same, and use of biosensing system |
| WO2022047848A1 (en) * | 2020-09-07 | 2022-03-10 | 科竟达生物科技有限公司 | Method for decorating nanocube on surface of optical waveguide of polymer, optical waveguide manufactured thereby, biosensing system, and application |
| CN116953847A (en) * | 2023-08-02 | 2023-10-27 | 桂林电子科技大学 | Mixed surface plasma directional coupler for network on optical sheet |
Non-Patent Citations (6)
| Title |
|---|
| CHEN, YU-BIN 等: "Tempering Hemispherical Radiative Properties with a Resonance Compilation", 《PLASMONICS 》, vol. 10, no. 3, XP035496889, DOI: 10.1007/s11468-014-9844-7 * |
| 华兰;冀克俭;邓卫华;刘元俊;邵鸿飞;: "自组装聚合物材料技术及其应用展望", 高分子材料科学与工程, no. 06 * |
| 吴振刚;刘燕梅;吴明明;陈颖;魏颖娜;羡皓晗;王学沛;魏恒勇;: "Au/TiN复合薄膜制备及其表面增强拉曼光谱研究", 光谱学与光谱分析, no. 02 * |
| 窦杰: "基于氮化钛纳米球的等离子体模式与光热耦合性质的研究", 《万方数据知识服务平台》 * |
| 邹盼: ""聚合物光波导生物传感器的制备与特性研究"", 《中国优秀硕士学位论文全文数据库 信息科技辑 (月刊)》, no. 7 * |
| 马颖: "基于氮化钛膜和金线的PCF-SPR传感特性研究", 《中国优秀硕士学位论文全文数据库 信息科技辑 (月刊)》, no. 10 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111999784B (en) | 2024-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Vaiano et al. | Lab on fiber technology for biological sensing applications | |
| Han et al. | Flexible self-cleaning broadband antireflective film inspired by the transparent cicada wings | |
| Ai et al. | Advanced colloidal lithography beyond surface patterning | |
| Li et al. | Ordered micro/nanostructured arrays based on the monolayer colloidal crystals | |
| Jiang et al. | Template-directed preparation of macroporous polymers with oriented and crystalline arrays of voids | |
| Huang et al. | Controlled replication of butterfly wings for achieving tunable photonic properties | |
| Gu et al. | Varying the optical stop band of a three-dimensional photonic crystal by refractive index control | |
| Skivesen et al. | Photonic-crystal waveguide biosensor | |
| Mivelle et al. | Ultrabright bowtie nanoaperture antenna probes studied by single molecule fluorescence | |
| Berini et al. | Long-range surface plasmons on ultrathin membranes | |
| Yan et al. | Artificial Defect Engineering in Three‐Dimensional Colloidal Photonic Crystals | |
| EP1416303A2 (en) | Functioning substrate with a group of columnar micro pillars and its manufacturing method | |
| Wendisch et al. | Confined etching within 2D and 3D colloidal crystals for tunable nanostructured templates: local environment matters | |
| Choudhury et al. | Silicon nanopillar arrays with SiO 2 overlayer for biosensing application | |
| Yan et al. | Layer transfer approach to opaline hetero photonic crystals | |
| Biswas et al. | Fabrication techniques and applications of two-dimensional photonic crystal: history and the present status | |
| Zhang et al. | Fabrication of gold-coated PDMS surfaces with arrayed triangular micro/nanopyramids for use as SERS substrates | |
| Li et al. | Durable broadband and omnidirectional ultra-antireflective surfaces | |
| Wang et al. | Flexible transfer of plasmonic photonic structures onto fiber tips for sensor applications in liquids | |
| Chen et al. | Reversibly thermoswitchable two-dimensional periodic gratings prepared from tethered poly (N-isopropylacrylamide) on silicon surfaces | |
| Jin et al. | Lasing and amplified spontaneous emission in a polymeric inverse opal photonic crystal resonating cavity | |
| Arcadio et al. | Biochemical sensing exploiting plasmonic sensors based on gold nanogratings and polymer optical fibers | |
| Li et al. | Convex-meniscus-assisted self-assembly at the air/water interface to prepare a wafer-scale colloidal monolayer without overlap | |
| Ye et al. | Integration of self-assembled three-dimensional photonic crystals onto structured silicon wafers | |
| US20100328774A1 (en) | Resonant reflective filter and biosensor including the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |