CN111991270B - Fullerene c60 energized eye lotion and preparation method thereof - Google Patents
Fullerene c60 energized eye lotion and preparation method thereof Download PDFInfo
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- CN111991270B CN111991270B CN202010984512.1A CN202010984512A CN111991270B CN 111991270 B CN111991270 B CN 111991270B CN 202010984512 A CN202010984512 A CN 202010984512A CN 111991270 B CN111991270 B CN 111991270B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention discloses fullerene c60 energized eye drops and a preparation method thereof. The eye lotion is prepared from the following raw materials in parts by weight: 65-85 parts of water, 0.01-0.05 part of EDTA (ethylene diamine tetraacetic acid), 0.1-1.0 part of hydrolyzed sodium hyaluronate, 1-10 parts of taurine, 1-5 parts of trehalose, 0.1-2 parts of sodium chloride, a pH regulator for regulating the pH of the eye lotion to be neutral, 10-25 parts of a functional extract and fullerene, wherein the content of the fullerene in the eye lotion is 0.1-0.8 mg/L. The fullerene c60 energized eye-moistening liquid comprises fullerene, various plants, microorganism extracts and other active substances, can remarkably improve eyesight and relieve asthenopia when being smeared on eyes, and can promote fibroblast proliferation.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to fullerene c60 energized eye lotion and a preparation method thereof.
Background
Asthenopia is a common ophthalmic disease, and dry eyes, sour eyes, blurred vision and even visual deterioration caused by asthenopia directly influence the work and life of people. The eyestrain is mainly caused by that when people concentrate on watching screens of electronic products such as televisions, computers or mobile phones and the like at ordinary times, the blinking frequency of eyes is reduced, the secretion of tears is correspondingly reduced, and meanwhile, a blinking screen strongly stimulates eyes. Eye fatigue can also cause and aggravate various eye diseases.
Fullerene is a novel cosmetic raw material, and no relevant report of adding fullerene into eye products exists at present.
Disclosure of Invention
The invention tries to add fullerene into an eye product to research the effect of the fullerene on eyes.
The invention discloses a fullerene c60 energized eye lotion which is prepared from the following raw materials in parts by weight:
65-85 parts of water, 0.01-0.05 part of EDTA (ethylene diamine tetraacetic acid), 0.1-1.0 part of hydrolyzed sodium hyaluronate, 1-10 parts of taurine, 1-5 parts of trehalose, 0.1-2 parts of sodium chloride, a pH regulator for regulating the pH of the eye lotion to be neutral, 10-25 parts of a functional extract, and fullerene, wherein the content of the fullerene in the eye lotion is 0.1-0.8mg/L, and the fullerene is a hydroxylated derivative of the fullerene. .
In some embodiments of the invention, the composition is prepared from the following raw materials in parts by weight:
70-80 parts of water, 0.01-0.03 part of EDTA (ethylene diamine tetraacetic acid), 0.3-0.8 part of hydrolyzed sodium hyaluronate, 1-5 parts of taurine, 1-3 parts of trehalose, 0.5-1 part of sodium chloride, a pH regulator for regulating the pH of the eye lotion to be neutral, 15-20 parts of a functional extract and fullerene, wherein the content of the fullerene in the eye lotion is 0.2-0.6mg/L, and the fullerene is a hydroxylated derivative of the fullerene.
In some embodiments of the invention, the fullerene is present in the eye lotion in an amount of 0.3 to 0.5 mg/L.
In some embodiments of the invention, the functional extract comprises a ratio by weight of a cucumber fruit extract, a witch hazel extract, a lactobacillus/ginseng root fermentation product filtrate, a schizosaccharomyces cerevisiae fermentation product lysate, and a biopolysaccharide gum of (5-15): (0.1-5): (0.1-5); (0.5-5): (1-10).
In some embodiments of the invention, the functional extract comprises a ratio by weight of a cucumber fruit extract, a witch hazel extract, a lactobacillus/ginseng root fermentation product filtrate, a schizosaccharomyces cerevisiae fermentation product lysate, and a biopolysaccharide gum of (8-12): (0.5-1.5): (0.5-1.5); (1-2): (3-8).
In some embodiments of the invention, the pH adjusting agent is citric acid.
The second aspect of the invention discloses a preparation method of the eye lotion, which comprises the following steps:
s1, mixing water and EDTA;
s2, adding hydrolyzed sodium hyaluronate, taurine, trehalose, sodium chloride and functional extract, and mixing;
s3, adding fullerene and mixing;
s4, adding a pH regulator to regulate the pH to 6.5-7.2.
In some embodiments of the present invention, in step S3, the minimum weight percentage of fullerene added to the eye lotion is determined by:
s31, setting the experimental range of fullerene, namely the weight percentage range a is more than C and less than b, wherein a is 0.01-0.05, and C is 2-3;
s32, dividing the experimental range into 2n +2 segments, wherein n is 1 or 2, the lengths of two adjacent segments are j and k, wherein k/j is 0.5 × (√ n +5)/(n +1)) -1), and preparing the eye lotion with the fullerene content of (2n +1) minutes;
s33, examining the microbiological performance of the (2n +1) eye drops, taking the test point l with the least bacteria number, and changing the experimental range into l-j < C < l + k;
s34, dividing j into 2n +2 sections, wherein j1 and k1 are arranged at two adjacent ends, and j1 is equal to j, and preparing eye drops with fullerene content of (2n +1) points;
s35, examining the microbiological performance of the prepared (2n +1) eye drops, S32-S34, until the minimum weight percentage of fullerene meeting the microbiological standard is found; the eye drop is inoculated with 10000cfu/ml of mould and 1000000cfu/ml of bacteria, if the mould is reduced by 90 percent at the 7 th day, the bacteria is reduced by 99.0 percent, and the number of bacteria is continuously reduced within 28 days, the eye drop meets the microbiological standard.
The beneficial technical effects of the invention are as follows:
the fullerene c60 energized eye-moistening liquid comprises fullerene, various plants, microorganism extracts and other active substances, can remarkably improve eyesight and relieve asthenopia when being smeared on eyes, and can promote fibroblast proliferation.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
The experimental procedures used in the following examples are all conventional procedures unless otherwise specified. Materials, reagents and the like used in the following examples are commercially available unless otherwise specified. The fullerene is a hydroxylated derivative of fullerene (C60(OH) x. nH2O), is dissolved in water and is purchased from Xiamen Funan New materials science and technology Co.
Example 1
Fullerene c60 energized eye lotion is prepared from raw materials and formula shown in tables 1 and 2.
The preparation method comprises adding the components of phase A into a container with stirring, mixing, and sequentially adding the components of phase B (except pH regulator) and phase D. During the mixing, heating may be optionally performed. Finally, the pH is adjusted to 6.5-7.2 by using a pH regulator.
TABLE 1 Fullerene c60 composition of energized eye drops
TABLE 2 Fullerene c60 formulation of energized eye drops
Example 2
Preparation method of fullerene c60 energized eye lotion
The difference from example 1 is that in step S3, the minimum weight percentage of fullerene added to the eye lotion is determined by:
s31, setting the experimental range of fullerene, namely the weight percentage range a is more than C and less than b, wherein a is 0.01-0.05, and C is 2-3;
s32, dividing the experimental range into 2n +2 sections, wherein n is 1 or 2, and the lengths of two adjacent sections are j and k, wherein
Preparing eye drops with fullerene content of (2n +1) points;
s33, examining the microbiological performance of the prepared (2n +1) eye drops, taking the test point l with the least bacteria number, and changing the test range into l-j < C < l + k;
s34, dividing j into 2n +2 sections, wherein j1 and k1 are arranged at two adjacent ends, and j1 is equal to j, and preparing eye drops with fullerene content of (2n +1) points;
s35, examining the microbiological performance of the prepared (2n +1) eye drops, and repeating S32-S34 until the minimum weight percentage of fullerene meeting the microbiological standard is found; the eye drop is inoculated with 10000cfu/ml of mould and 1000000cfu/ml of bacteria, if the mould is reduced by 90 percent at the 7 th day, the bacteria is reduced by 99.0 percent, and the number of bacteria is continuously reduced within 28 days, the eye drop meets the microbiological standard.
The weight percentage of fullerene in the eye lotion determined by the method of the embodiment quickly determines the minimum value of fullerene under the premise of meeting the microbiological standard. Not only plays the role of oxidation resistance and corrosion prevention, ensures that the product meets the sanitary standard, but also plays the role of adjusting the functions of eyes.
Experimental examples functional testing of energized eye drops
Subject: the aged 25 years old, unlimited in nature, neutral in skin, no history of skin allergy, and no eye diseases in recent years.
Experiment 1 eye feel
The experimental reagent used the eye-moistening solution prepared in the examples, and the control reagent used 0.5% by weight aqueous sodium carboxymethylcellulose solution.
After the subjects washed their faces, the eyes were closed. The experimenter lightly smears 2ml of the experimental group reagent and the control group reagent respectively on the eyelids of the experimental objects in two times, and lightly smears for 15 s. The eye feeling of the experimental subject is recorded in an investigation mode, and the main investigation indexes are subjective feeling such as definition, brightness, swelling, dryness, fatigue and the like. If the improvement is obvious, the score is 3, if the improvement is 1, the score is 0 if no difference is sensed. The results are shown in Table 3.
TABLE 3 eye feel
| Reagent for experimental group | Eye feeling | Control group reagent | Eye feeling |
| Formulation 1 | 2.1 | Comparative example | 1.3 |
| Formulation 2 | 2.5 | Comparative example | 1.4 |
| Formulation 3 | 2.8 | Comparative example | 1.3 |
| Formulation 4 | 2.4 | Comparative example | 1.4 |
| Formulation 5 | 2.2 | Comparative example | 1.4 |
Experiment 2 Effect on fibroblasts
The experimental group reagents were energized eye lotions prepared in formulations 1-5 of example 1.
The control reagents differ from the formulations 1-5 of example 1, respectively, in that the fullerene component is absent from the formulation and is made up to 100% with water. The preparation process is similar to that of the examples, omitting only the step of adding the phase D component.
The fibroblasts for the experiment are fibroblasts which are obtained by carrying out about 10 passages on primary cells, the primary seed fibroblasts are from human foreskin, the cells are cultured in a DMEM culture medium in an incubator with 37 ℃ and 5% CO2 saturated humidity, and one half of the culture medium is replaced every 24 hours.
In the experimental group, 90% of the culture medium and 10% of the reagent in the experimental group are calculated by volume; control group, 90% + 10% control group reagent.
After 7d of culture, cell proliferation was measured by the MTT method. The results are shown in Table 4.
TABLE 4 Effect of energized eye drops on fibroblast proliferation
| Experimental group | OD value | Control group | OD value |
| 1 | 0.620 | 1 | 0.608 |
| 2 | 0.632 | 2 | 0.587 |
| 3 | 0.628 | 3 | 0.559 |
| 4 | 0.615 | 4 | 0.573 |
| 5 | 0.617 | 5 | 0.592 |
While the preferred embodiments and examples of the present invention have been described in detail, the present invention is not limited to the embodiments and examples, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (6)
1. A fullerene c60 eye drops is prepared from the following raw materials in parts by weight:
65-85 parts of water, 0.01-0.05 part of EDTA (ethylene diamine tetraacetic acid), 0.1-1.0 part of hydrolyzed sodium hyaluronate, 1-10 parts of taurine, 1-5 parts of trehalose, 0.1-2 parts of sodium chloride, a pH regulator for regulating the pH of the eye lotion to be neutral, 10-25 parts of a functional extract and fullerene, wherein the content of the fullerene in the eye lotion is 0.1-0.8mg/L, and the fullerene is a hydroxylated derivative of the fullerene;
the functional extract comprises cucumber fruit extract, hamamelis virginiana extract, lactobacillus/ginseng root fermentation product filtrate, schizosaccharomyces cerevisiae fermentation product lysate and biological polysaccharide gum;
the weight ratio of the cucumber fruit extract, the hamamelis virginiana extract, the lactobacillus/ginseng root fermentation product filtrate, the schizosaccharomyces cerevisiae fermentation product lysate and the biological polysaccharide gum in the functional extract is (5-15): (0.1-5): (0.1-5); (0.5-5): (1-10);
the eye lotion is applied to the skin of the eyes.
2. The eye lotion according to claim 1, which is prepared from the following raw materials in parts by weight:
70-80 parts of water, 0.01-0.03 part of EDTA (ethylene diamine tetraacetic acid), 0.3-0.8 part of hydrolyzed sodium hyaluronate, 1-5 parts of taurine, 1-3 parts of trehalose, 0.5-1 part of sodium chloride, a pH regulator for regulating the pH of the eye lotion to be neutral, 15-20 parts of a functional extract and fullerene, wherein the content of the fullerene in the eye lotion is 0.2-0.6mg/L, and the fullerene is a hydroxylated derivative of the fullerene.
3. The eye lotion according to claim 1 or 2, wherein the fullerene is contained in the eye lotion in an amount of 0.3 to 0.5 mg/L.
4. The eyedrop of claim 1, wherein the weight ratio of the cucumber fruit extract, the hamamelis virginiana extract, the lactobacillus/ginseng root fermentation product filtrate, the schizosaccharomyces cerevisiae fermentation product lysate and the biopolysaccharide gum in the functional extract is (8-12): (0.5-1.5): (0.5-1.5); (1-2): (3-8).
5. The eye lotion according to claim 1 or 2, wherein the pH-adjusting agent is citric acid.
6. A method for preparing an eye drop according to any one of claims 1 to 5, comprising the steps of:
s1, mixing water and EDTA;
s2, adding hydrolyzed sodium hyaluronate, taurine, trehalose, sodium chloride and functional extract, and mixing;
s3, adding fullerene and mixing;
s4, adding a pH regulator to regulate the pH to 6.5-7.2.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106727033A (en) * | 2017-01-23 | 2017-05-31 | 湖北丽生堂生物科技有限公司 | A kind of anti-ageing lutein compound plant facial mask of moisturizing |
| CN109464343A (en) * | 2018-12-29 | 2019-03-15 | 广州灵润生物科技有限公司 | A kind of clear essence cream of the polypeptide containing fullerene |
| CN110075058A (en) * | 2019-06-17 | 2019-08-02 | 栾兆东 | It is a to supplement eye skin nutrition, desalination wrinkle, the young eye cream for improving eye pouch and preparation method thereof |
| CN110339137A (en) * | 2019-08-29 | 2019-10-18 | 广州重生化妆品实业有限公司 | The formula and preparation method thereof of one primary yeast beauty treatment essence |
| CN111419793A (en) * | 2020-04-29 | 2020-07-17 | 上海紫河生物科技有限公司 | Eye drops containing fullerene and fullerene derivatives and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324646A (en) * | 2018-04-16 | 2018-07-27 | 广州雷诺生物科技有限公司 | A kind of moisturizer containing fullerene |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727033A (en) * | 2017-01-23 | 2017-05-31 | 湖北丽生堂生物科技有限公司 | A kind of anti-ageing lutein compound plant facial mask of moisturizing |
| CN109464343A (en) * | 2018-12-29 | 2019-03-15 | 广州灵润生物科技有限公司 | A kind of clear essence cream of the polypeptide containing fullerene |
| CN110075058A (en) * | 2019-06-17 | 2019-08-02 | 栾兆东 | It is a to supplement eye skin nutrition, desalination wrinkle, the young eye cream for improving eye pouch and preparation method thereof |
| CN110339137A (en) * | 2019-08-29 | 2019-10-18 | 广州重生化妆品实业有限公司 | The formula and preparation method thereof of one primary yeast beauty treatment essence |
| CN111419793A (en) * | 2020-04-29 | 2020-07-17 | 上海紫河生物科技有限公司 | Eye drops containing fullerene and fullerene derivatives and preparation method thereof |
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