CN111990972A - System, device and storage medium for determining unconsciousness point in anesthesia induction period - Google Patents

System, device and storage medium for determining unconsciousness point in anesthesia induction period Download PDF

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Publication number
CN111990972A
CN111990972A CN202010923107.9A CN202010923107A CN111990972A CN 111990972 A CN111990972 A CN 111990972A CN 202010923107 A CN202010923107 A CN 202010923107A CN 111990972 A CN111990972 A CN 111990972A
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patient
anesthesia
determining
value
ioc2
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卞汉道
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Shanghai Ruianxing Medical Technology Co ltd
Shenzhen City Weihaokang Medical Instrument Ltd
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Shenzhen City Weihaokang Medical Instrument Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4821Determining level or depth of anaesthesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M2005/14208Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a system, a device and a storage medium for determining a loss consciousness point in an anesthesia induction period, wherein the system is still in a waking state after giving pain-relieving medicines, subjective pain still exists, and IOC2 cannot be reduced; the system prompts the operator to inform the patient that surgery is about to begin, and vocally stimulates the patient's subjective pain to a peak, resulting in an IOC2 value of 99; analgesic is effective, the system gives sedative slowly, and as the dosage is increased, the consciousness index IOC1 is reduced, but the subjective consciousness still exists, and the IOC2 value is not reduced; subjective consciousness is lost in the morning and evening with the increase of the sedative dosage, subjective pain disappears, only objective pain is achieved, the IOC2 shows cliff type reduction due to the prior administration of analgesic, and when the IOC2 shows reduction, the IOC1 value is read, and the value is the consciousness index critical value of the patient loss consciousness. The invention provides a system, a device and a storage medium for determining an unconscious point in an anesthesia induction period, and the sedation depth of each anesthesia patient is accurately controlled through an IOC1 and an IOC 2.

Description

System, device and storage medium for determining unconsciousness point in anesthesia induction period
Technical Field
The invention relates to the field of medical anesthesia, in particular to a system, a device and a storage medium for determining an unconsciousness point in an anesthesia induction period.
Background
Ensuring that patients receive surgical treatment smoothly under painless and safe conditions is a basic task of anesthesia clinic, but the task is only a part of the work content of modern anesthesia disciplines. The anesthesia work also comprises preparation and treatment before and after anesthesia, monitoring and treatment of critical patients, emergency resuscitation, pain treatment and the like. In order to complete clinical anesthesia, the basic theory of anesthesia and the skilled application of various anesthesia techniques are required to be mastered, and the characteristics of various surgical operations are required to be familiar. From the normal distribution graph of the consciousness index, for an individual, the higher the consciousness index is, the lighter the sedation is, and the lower the consciousness index is, the deeper the sedation is; for a population, the index of consciousness is high, sedation is not necessarily shallow, the index of consciousness is low, sedation is not necessarily deep; 40-60 patients can only be said to be appropriate; the anesthesiologist needs to be responsible for each patient facing each patient, and the sedation depth of each anesthetized patient cannot be controlled to be accurate only by one parameter; many surgeries require shallow anesthesia, which is a medical accident, and doctors pay attention to intraoperative awareness; if we can determine the unconsciousness point of the operation patient in the induction period, namely the consciousness point of the patient, under the monitoring environment, the intraoperative knowledge which is the most worried of the anaesthetist all the time is avoided, and no good pre-existing control standard exists.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the main objective of the present invention is to provide a system, a device and a storage medium for determining the unconsciousness point during the induction period of anesthesia, which can precisely control the sedation depth of each anesthesia patient through two parameters, i.e. IOC1 and IOC2, thereby avoiding the intraoperative awareness.
In order to achieve the above object, the present invention provides an electronic device, which includes a memory and a processor, wherein the memory stores a system for determining an unconsciousness point during an anesthesia induction period, which is operable on the processor, and when being executed by the processor, the system for determining the unconsciousness point during the anesthesia induction period implements the following steps:
s1, the system gives analgesic to the patient according to the instruction of the operator;
s2, calculating the onset time by the system, prompting an operator to inform a patient that the operation is about to start, and prompting the subjective pain of the patient to reach the peak by voice;
s3, the system gives a sedative to the patient according to the instruction of the operator, after the sedative is given, the consciousness of the patient is reduced, the system receives data that the IOC1 value is reduced, and the IOC2 cannot be reduced;
s4, the system reads the IOC1 value after receiving the IOC2 value descending data.
In one embodiment, the rate of administration is slow when both the analgesic and the sedative are administered to the patient.
In one embodiment, prior to administration to the patient, the type of drug and the rate of administration to be administered during the maintenance period will also be displayed and instructed by the operator to modify the type of administration and the rate of pumping.
The method for operating the system for determining the point of unconsciousness during the induction period of anesthesia comprises the following steps:
the system first administers analgesic to the patient according to operator instructions;
the system calculates the onset time and prompts the operator to inform the patient that surgery is about to begin, and voice prompts stimulate the subjective pain of the patient to reach the peak, i.e., IOC2 is 99;
the system administers a sedative to the patient according to the operator's instructions, and after the sedative is administered, the patient's consciousness is reduced, the system receives a drop in the value of IOC1, and the value of IOC2 does not drop;
after the system receives the IOC2 value drop data, the system reads the IOC1 value, which is the loss of consciousness threshold.
In one embodiment, the method is characterized by administering the analgesic and the sedative at a rate that is slow when both are administered to the patient.
In one embodiment, prior to administration to the patient, the type of drug and the rate of administration to be administered during the maintenance period will also be displayed and instructed by the operator to modify the type of administration and the rate of pumping.
In one embodiment, after determining the sedation index based on IOC1 and IOC2, if the monitored parameters, the drug delivery rate, and the patient are not abnormal, the system will enter the anesthesia maintenance phase management, which includes a maintenance phase routine management system, an intra-operative awareness prevention management subsystem, an anesthesia accumulation prevention management subsystem, and an intra-operative BS processing subsystem.
A computer readable storage medium having stored thereon a system for determining a point of loss of consciousness during anesthesia induction, the system for determining a point of loss of consciousness during anesthesia induction implementing the steps of the method for operating the system for determining a point of loss of consciousness during anesthesia induction when executed by a processor.
The invention has the following beneficial effects:
the system gives analgesic medicines to the patient according to the instruction of an operator, after the analgesic medicines are given, the patient is still in a waking state, the subjective pain of the patient still exists, and the IOC2 cannot be reduced; the system calculates the onset time and prompts the operator to inform the patient that the surgery is about to begin, and the voice prompts the subjective pain of the patient to be stimulated to reach the peak, so that the IOC2 value is 99; when the analgesic is effective, the system gives the patient sedative according to the instruction of an operator, and when the sedative is given slowly, the patient consciousness index IOC1 is reduced along with the increase of the sedative amount, but the subjective consciousness still exists and the IOC2 value is not reduced; with the increase of the amount of sedative, the patient loses the subjective consciousness in the morning and evening, the subjective consciousness disappears, the subjective pain of the patient disappears, only objective pain exists, and the IOC2 value is decreased in a cliff manner due to the prior administration of analgesic; when a cliff-like drop in IOC2 occurred, the IOC1 value was read, which is the index of consciousness threshold for the point of unconsciousness of the patient. The invention provides a system, a device and a storage medium for determining an unconscious point in an anesthesia induction period, which can accurately control the sedation depth of each anesthesia patient through two parameters, namely IOC1 and IOC 2.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic view of an electronic device according to the present invention.
Fig. 2 is a flow chart illustrating the operation steps of the system for determining the point of unconsciousness during the induction period of anesthesia according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clearly and completely apparent, the technical solutions in the embodiments of the present invention will be described below with reference to the accompanying drawings in the embodiments of the present invention. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that all the directional indicators (e.g., upper, lower, left, right, front, and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the movement condition, etc. in a specific state (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly.
Descriptions in this specification as relating to "first", "second", etc. are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicit to any indicated technical feature or quantity. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature.
In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly specified or limited, the terms "connected," "secured," and the like are to be construed broadly, and for example, "secured" may be a fixed connection, a removable connection, or an integral molding; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In addition, the technical solutions in the embodiments of the present invention may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination of technical solutions should not be considered to exist, and is not within the protection scope of the present invention.
The invention provides a system for determining an unconsciousness point during an induction period of anesthesia. Referring to fig. 1, a schematic operating environment of a system for determining a point of unconsciousness during an induction period of anesthesia according to a preferred embodiment of the present invention is shown.
In the present embodiment, the system 12 for determining the unconsciousness point during the induction period of anesthesia is installed and operated in the electronic device 1.
The electronic device 1 is a device capable of automatically performing numerical calculation and/or information processing in accordance with a command set or stored in advance. The electronic device 1 may be a computer, or may be a single network server, a server group composed of a plurality of network servers, or a cloud composed of a large number of hosts or network servers based on cloud computing, where the cloud computing is one of distributed computing, and is a super virtual computer composed of a group of loosely coupled computers, and in the present embodiment, is an injection pump for implementing anesthesia.
In the present embodiment, the electronic device 1 may include, but is not limited to, a memory 11, a processor 12 and a network interface 13, which are communicatively connected to each other through a system bus, wherein the memory 11 stores a system 12 operable on the processor 12 for determining a point of unconsciousness during an anesthesia induction period. It is noted that fig. 1 only shows the electronic device 1 with components 11-13, but it is to be understood that not all shown components are required to be implemented, and that more or less components may be implemented instead. The storage 11 includes a memory and at least one type of readable storage medium. The memory provides cache for the operation of the electronic device 1; the readable storage medium may be a nonvolatile storage medium such as a flash memory, a hard disk, a multimedia card, a card type memory 11 (e.g., SD or DX memory 11, etc.), a random access memory 11(RAM), a static random access memory 11(SRAM), a read only memory 11(ROM), an electrically erasable programmable read only memory 11(EEPROM), a programmable read only memory 11(PROM), a magnetic memory 11, a magnetic disk, an optical disk, etc. In some embodiments, the readable storage medium may be an internal storage unit of the electronic apparatus 1, such as a hard disk of the electronic apparatus 1; in other embodiments, the non-volatile storage medium may also be an external storage device of the electronic apparatus 1, such as a plug-in hard disk provided on the electronic apparatus 1, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), and the like. In this embodiment, the readable storage medium of the memory 11 is generally used for storing an operating system and various types of application software installed in the electronic device 1, such as a system 12 for determining a loss of consciousness during anesthesia induction in an embodiment of the present invention. Further, the memory 11 may also be used to temporarily store various types of data that have been output or are to be output.
The processor 12 may be, in some embodiments, a Central Processing Unit (CPU) 12, a controller, a microcontroller, a microprocessor 12, or other data Processing chip. The processor 12 is used for controlling the overall operation of the electronic apparatus 1, such as performing control and processing related to data interaction or communication with the other devices. In this embodiment, the processor 12 is configured to run program codes stored in the memory 11 or process data, such as the system 12 for determining a point of unconsciousness during an induction period of anesthesia.
The network interface 13 may include a wireless network interface 13 or a wired network interface 13, and the network interface 13 is generally used for establishing a communication connection between the electronic apparatus 11 and other electronic devices.
The system 12 for determining a point of loss of consciousness during anesthesia induction includes at least one computer readable instruction stored in the memory 11, the at least one computer readable instruction being executable by the processor 12 to implement embodiments of the present invention.
Wherein, the system for determining the unconsciousness point in the anesthesia induction period realizes the following steps when being executed by the processor:
the system first administers analgesic to the patient according to operator instructions;
the system calculates the onset time and prompts an operator to inform a patient that the operation is about to start, and the subjective pain stimulating the patient is prompted to reach the peak by voice;
the system administers a sedative to the patient according to the operator's instructions, after the sedative is administered, the patient's consciousness is reduced, the system receives data that the IOC1 value is reduced and the IOC2 value is not reduced;
the system reads the IOC1 value after receiving the IOC2 value descent data.
Preferably, the rate of administration is slow when both the analgesic and sedative are administered to a patient.
Preferably, before the administration to the patient, the type of drug and the administration rate at which the drug is to be administered during the maintenance period will also be displayed, and the operator will be instructed to modify the type of administration and the pump rate.
The method for operating the system for determining the point of unconsciousness during the induction period of anesthesia comprises the following steps:
the system first administers analgesic to the patient according to operator instructions;
the system calculates the onset time and prompts an operator to inform a patient that the operation is about to start, and the subjective pain stimulating the patient is prompted to reach the peak by voice;
the system administers a sedative to the patient according to the operator's instructions, and after the sedative is administered, the patient's consciousness is reduced, the system receives data that the IOC1 value is reduced and the IOC2 value is not reduced;
the system reads the IOC1 value after receiving the IOC2 value descent data.
Preferably, the method is characterized in that the rate of administration is slow when both the analgesic and the sedative are administered to the patient.
Preferably, before the administration to the patient, the type of drug and the administration rate at which the drug is to be administered during the maintenance period will also be displayed, and the operator will be instructed to modify the type of administration and the pump rate.
Preferably, after determining the sedation index based on IOC1 and IOC2, if the monitored parameters, the drug delivery rate, and the patient are not abnormal, the system will enter the maintenance phase of anesthesia management, which includes a maintenance phase routine management system, a management system for prevention of awareness, a management subsystem for prevention of accumulation, and a BS processing subsystem during surgery.
A computer readable storage medium having stored thereon a system for determining a point of loss of consciousness during anesthesia induction, the system for determining a point of loss of consciousness during anesthesia induction implementing the steps of the method for operating the system for determining a point of loss of consciousness during anesthesia induction when executed by a processor.
The specific implementation of the computer-readable storage medium of the present invention is substantially the same as the embodiments of the electronic device and the method described above, and will not be described herein again.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Through the above description of the embodiments, those skilled in the art will clearly understand that the above embodiment method can be implemented by a general hardware platform of software plus advocate, and certainly can be implemented by hardware, but in many cases, the former is a better embodiment. Based on such understanding, the technical solutions of the present invention may be embodied in the form of a software product, which is stored in a storage medium (such as ROM/RAM, magnetic disk, optical disk) and includes instructions for enabling a terminal device (such as a mobile phone, a computer, a server, an air conditioner, or a network device) to execute the method according to the embodiments of the present invention.
The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, and are not to be construed as limiting the scope of the invention. The above-mentioned serial numbers of the embodiments of the present invention are merely for description and do not represent the merits of the embodiments. Additionally, while a logical order is shown in the flow diagrams, in some cases, the steps shown or described may be performed in an order different than here.
Those skilled in the art can implement the invention in various modifications, such as features from one embodiment can be used in another embodiment to yield yet a further embodiment, without departing from the scope and spirit of the invention. Any modification, equivalent replacement and improvement made within the technical idea of using the present invention should be within the scope of the right of the present invention.

Claims (8)

1. An electronic device comprising a memory and a processor, the memory having stored thereon a system for determining a point of unconsciousness during an anesthesia induction period operable on the processor, the system for determining a point of unconsciousness during an anesthesia induction period when executed by the processor performing the steps of:
s1, the system gives analgesic to the patient according to the instruction of the operator;
s2, calculating the onset time by the system, prompting an operator to inform a patient that the operation is about to start, and prompting the subjective pain of the patient to reach the peak by voice;
s3, the system gives a sedative to the patient according to the instruction of the operator, after the sedative is given, the consciousness of the patient is reduced, the system receives data that the IOC1 value is reduced, and the IOC2 cannot be reduced;
s4, the system reads the IOC1 value after receiving the IOC2 value descending data.
2. The electronic device of claim 1, wherein the rate of administration is slow when both the analgesic and sedative are administered to the patient.
3. The electronic device of claim 1, wherein before the administration of the drug to the patient, the type of drug to be administered during the maintenance period and the administration rate are displayed, and the operator is instructed to modify the type of drug to be administered and the pump rate.
4. A method of operating a system for determining a point of loss of consciousness during anesthesia induction, the method comprising:
the system first administers analgesic to the patient according to operator instructions;
the system calculates the onset time and prompts an operator to inform a patient that the operation is about to start, and the subjective pain stimulating the patient is prompted to reach the peak by voice;
the system administers a sedative to the patient according to the operator's instructions, after the sedative is administered, the patient's consciousness is reduced, the system receives data that the IOC1 value is reduced and the IOC2 value is not reduced;
the system reads the IOC1 value after receiving the IOC2 value descent data.
5. The method of claim 4 wherein the analgesic and sedative are administered at a rate that is slow for both patients.
6. A method of operating a system for determining a point of unconsciousness during the induction period of anesthesia as defined in claim 4, wherein prior to administration to the patient, the type of drug to be administered during the maintenance period and the rate of administration are also displayed, and operator instructions for modifying the type of administration and the rate of administration are received.
7. The method of claim 4 wherein the determining the sedation index based on IOC1 and IOC2, the monitoring parameters, the rate of drug delivery and the absence of patient abnormalities is followed by the system entering the maintenance phase of anesthesia management comprising a maintenance phase routine management system, a maintenance awareness prevention management subsystem, an accumulation prevention management subsystem, and an intraoperative BS processing subsystem.
8. A computer-readable storage medium, having stored thereon a system for determining a point of unconsciousness during an induction period of anesthesia, which when executed by a processor, performs the steps of a method of operating the system for determining a point of unconsciousness during an induction period of anesthesia as defined in any one of claims 4 to 7.
CN202010923107.9A 2020-09-04 2020-09-04 System, device and storage medium for determining unconsciousness point in anesthesia induction period Pending CN111990972A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2207848C2 (en) * 2001-06-27 2003-07-10 Козлов Игорь Александрович Method for applying multiple component anesthesia in the cases of surgical interventions
CN1739561A (en) * 2005-09-23 2006-03-01 赵超英 Application of high permeability medicine composition in preparing pre-nacrosis medicine
WO2008059289A2 (en) * 2006-11-13 2008-05-22 Alan Hector Wenman Depth of anaesthesia
CN104887225A (en) * 2015-06-04 2015-09-09 卞汉道 Instrument and method for monitoring anesthesia precision
CN105943365A (en) * 2016-05-31 2016-09-21 张岩 Electronic acupuncture painless needle therapy instrument and dye
JP2019017730A (en) * 2017-07-18 2019-02-07 国立大学法人福井大学 Anaesthesia auxiliary program, anaesthesia auxiliary device, anaesthesia auxiliary system and anaesthesia auxiliary method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2207848C2 (en) * 2001-06-27 2003-07-10 Козлов Игорь Александрович Method for applying multiple component anesthesia in the cases of surgical interventions
CN1739561A (en) * 2005-09-23 2006-03-01 赵超英 Application of high permeability medicine composition in preparing pre-nacrosis medicine
WO2008059289A2 (en) * 2006-11-13 2008-05-22 Alan Hector Wenman Depth of anaesthesia
CN104887225A (en) * 2015-06-04 2015-09-09 卞汉道 Instrument and method for monitoring anesthesia precision
CN105943365A (en) * 2016-05-31 2016-09-21 张岩 Electronic acupuncture painless needle therapy instrument and dye
JP2019017730A (en) * 2017-07-18 2019-02-07 国立大学法人福井大学 Anaesthesia auxiliary program, anaesthesia auxiliary device, anaesthesia auxiliary system and anaesthesia auxiliary method

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Inventor after: Bian Handao

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Address after: 518000 Sunshine Industrial Zone, Sunshine Road, Xili Street, Nanshan District, Shenzhen City, Guangdong Province, 6 buildings 601-2

Applicant after: Shenzhen city Weihaokang medical instrument Ltd.

Applicant after: Shanghai ruianxing Medical Technology Co.,Ltd.

Address before: 518000 Sunshine Industrial Zone, Sunshine Road, Xili Street, Nanshan District, Shenzhen City, Guangdong Province, 6 buildings 601-2

Applicant before: Shenzhen city Weihaokang medical instrument Ltd.

CB02 Change of applicant information
CB02 Change of applicant information

Address after: 518000 Sunshine Industrial Zone, Sunshine Road, Xili Street, Nanshan District, Shenzhen City, Guangdong Province, 6 buildings 601-2

Applicant after: Shenzhen city Weihaokang medical instrument Ltd.

Applicant after: Rui'anxing Medical Technology (Suzhou) Co.,Ltd.

Address before: 518000 Sunshine Industrial Zone, Sunshine Road, Xili Street, Nanshan District, Shenzhen City, Guangdong Province, 6 buildings 601-2

Applicant before: Shenzhen city Weihaokang medical instrument Ltd.

Applicant before: Shanghai ruianxing Medical Technology Co.,Ltd.