CN111989109A - 靶向cd33的抗体可变结构域及其用途 - Google Patents

靶向cd33的抗体可变结构域及其用途 Download PDF

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CN111989109A
CN111989109A CN201980025297.8A CN201980025297A CN111989109A CN 111989109 A CN111989109 A CN 111989109A CN 201980025297 A CN201980025297 A CN 201980025297A CN 111989109 A CN111989109 A CN 111989109A
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seq
amino acid
acid sequence
chain variable
sequence
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格雷戈里·P·张
安·F·张
阿斯亚·格林伯格
杜鲁弗·金·塞西
威廉·哈尼
比昂卡·普林茨
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Dragonfly Therapy
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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CN201980025297.8A 2018-02-20 2019-02-20 靶向cd33的抗体可变结构域及其用途 Pending CN111989109A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862632756P 2018-02-20 2018-02-20
US62/632,756 2018-02-20
PCT/US2019/018748 WO2019164929A1 (en) 2018-02-20 2019-02-20 Antibody variable domains targeting cd33, and use thereof

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CN111989109A true CN111989109A (zh) 2020-11-24

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US (1) US20200376034A1 (https=)
EP (1) EP3755348A4 (https=)
JP (2) JP7539840B2 (https=)
KR (1) KR20200133222A (https=)
CN (1) CN111989109A (https=)
AU (1) AU2019225740A1 (https=)
BR (1) BR112020016944A2 (https=)
CA (1) CA3091764A1 (https=)
CL (2) CL2020002143A1 (https=)
EA (1) EA202091976A1 (https=)
IL (1) IL276776A (https=)
MX (1) MX2020008683A (https=)
PE (1) PE20211224A1 (https=)
SG (1) SG11202007943RA (https=)
TW (1) TW201945390A (https=)
WO (1) WO2019164929A1 (https=)

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BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
WO2019164930A1 (en) * 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
PE20221316A1 (es) * 2019-10-15 2022-09-07 Dragonfly Therapeutics Inc Proteinas que se unen a nkg2d, cd16 y flt3
JP7512394B2 (ja) * 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
EP4291233A4 (en) * 2021-02-10 2025-05-21 Wugen, Inc. POLYPEPTIDES AND THEIR USE IN THE TREATMENT OF DISEASES
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
US20250082681A1 (en) * 2021-07-30 2025-03-13 Nanjing Legend Biotech Co., Ltd. Antibodies against cll1 and constructs thereof
WO2023015322A1 (en) * 2021-08-06 2023-02-09 Actinium Pharmaceuticals, Inc. Radioconjugates targeting cd33 in the treatment of cancers
AR127162A1 (es) * 2021-09-29 2023-12-27 Dragonfly Therapeutics Inc Proteínas que se unen a nkg2d, cd16 y baff-r
CN118251411A (zh) * 2021-09-29 2024-06-25 摩德斯医疗股份有限公司 抗原结合多肽、抗原结合多肽复合物及其使用方法
JP2025508740A (ja) * 2022-02-17 2025-04-10 アノキオン・ソシエテ・アノニム 抗ａｓｇｒ１ポリペプチドおよび免疫寛容のための使用
WO2024249235A1 (en) * 2023-06-01 2024-12-05 Abbvie Inc. Anti-human cd33 bet degrader antibody-drug conjugates
WO2025233431A1 (en) * 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Heteromeric proteins comprising three heteromerization improving substitution, production, combinations and applications thereof

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