CN111989109A - 靶向cd33的抗体可变结构域及其用途 - Google Patents

靶向cd33的抗体可变结构域及其用途 Download PDF

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CN111989109A
CN111989109A CN201980025297.8A CN201980025297A CN111989109A CN 111989109 A CN111989109 A CN 111989109A CN 201980025297 A CN201980025297 A CN 201980025297A CN 111989109 A CN111989109 A CN 111989109A
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seq
amino acid
acid sequence
chain variable
sequence
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格雷戈里·P·张
安·F·张
阿斯亚·格林伯格
杜鲁弗·金·塞西
威廉·哈尼
比昂卡·普林茨
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Dragonfly Therapy
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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CN201980025297.8A 2018-02-20 2019-02-20 靶向cd33的抗体可变结构域及其用途 Pending CN111989109A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862632756P 2018-02-20 2018-02-20
US62/632,756 2018-02-20
PCT/US2019/018748 WO2019164929A1 (en) 2018-02-20 2019-02-20 Antibody variable domains targeting cd33, and use thereof

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CN111989109A true CN111989109A (zh) 2020-11-24

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CN201980025297.8A Pending CN111989109A (zh) 2018-02-20 2019-02-20 靶向cd33的抗体可变结构域及其用途

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US (1) US20200376034A1 (https=)
EP (1) EP3755348A4 (https=)
JP (2) JP7539840B2 (https=)
KR (1) KR20200133222A (https=)
CN (1) CN111989109A (https=)
AU (1) AU2019225740A1 (https=)
BR (1) BR112020016944A2 (https=)
CA (1) CA3091764A1 (https=)
CL (2) CL2020002143A1 (https=)
EA (1) EA202091976A1 (https=)
IL (1) IL276776A (https=)
MX (1) MX2020008683A (https=)
PE (1) PE20211224A1 (https=)
SG (1) SG11202007943RA (https=)
TW (1) TW201945390A (https=)
WO (1) WO2019164929A1 (https=)

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DK3749346T3 (da) 2018-02-08 2024-09-09 Dragonfly Therapeutics Inc Antistof variable domænekombinationer rettet mod nkg2d-receptoren
WO2019164930A1 (en) * 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
WO2020033630A1 (en) 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
US12378318B2 (en) 2018-08-08 2025-08-05 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and a tumor-associated antigen
EP3962527A4 (en) 2019-04-30 2023-11-01 Senti Biosciences, Inc. CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
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MX2022013944A (es) * 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
EP4291233A4 (en) * 2021-02-10 2025-05-21 Wugen, Inc. POLYPEPTIDES AND THEIR USE IN THE TREATMENT OF DISEASES
JP2024508894A (ja) 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
US20250082681A1 (en) * 2021-07-30 2025-03-13 Nanjing Legend Biotech Co., Ltd. Antibodies against cll1 and constructs thereof
WO2023015322A1 (en) * 2021-08-06 2023-02-09 Actinium Pharmaceuticals, Inc. Radioconjugates targeting cd33 in the treatment of cancers
WO2023056252A1 (en) * 2021-09-29 2023-04-06 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and baff-r
CN118591388A (zh) * 2021-09-29 2024-09-03 摩德斯医疗股份有限公司 抗原结合多肽、抗原结合多肽复合物及其使用方法
US20250381255A1 (en) * 2022-02-17 2025-12-18 Anokion Sa Anti-asgr1 polypeptides and methods of use for immune tolerance
WO2024249235A1 (en) * 2023-06-01 2024-12-05 Abbvie Inc. Anti-human cd33 bet degrader antibody-drug conjugates
WO2025233431A1 (en) * 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Heteromeric proteins comprising three heteromerization improving substitution, production, combinations and applications thereof

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