CN111983667A - Scintillator-based micro-dosage measuring method and device - Google Patents
Scintillator-based micro-dosage measuring method and device Download PDFInfo
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- CN111983667A CN111983667A CN202010667908.3A CN202010667908A CN111983667A CN 111983667 A CN111983667 A CN 111983667A CN 202010667908 A CN202010667908 A CN 202010667908A CN 111983667 A CN111983667 A CN 111983667A
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- scintillator
- scintillation light
- image intensifier
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/20—Measuring radiation intensity with scintillation detectors
- G01T1/208—Circuits specially adapted for scintillation detectors, e.g. for the photo-multiplier section
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
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Abstract
The invention provides a method and a device for measuring micro-dosage based on a scintillator. Furthermore, a particle bombarding scintillator detector excites scintillation light, the scintillation light is amplified by a steering mirror, an image intensifier and a lens group and then is transmitted to an imaging unit, and then a scintillation light image is output. Further, the intensity of the scintillation light is calibrated to give a dose equivalent. Since the imaging unit pixels are substantially on the order of a few microns to tens of microns, each pixel value in the resulting image represents the energy deposited in one sensitive unit, i.e., the energy deposition in each cell. Further, the time variation of the energy deposition in each sensitive unit can be obtained by properly changing the exposure time of the camera.
Description
Technical Field
The invention relates to the technical field of micro-dosage measurement, in particular to a scintillator-based micro-dosage measurement method and device.
Background
The hazard of ionizing radiation depends on the distribution of its deposited energy within the human body and the resulting microscopic-scale complex biological processes, and the indicator quantifying this hazard is the radiation bioeffect. The macroscopic dose gives the total energy deposition, i.e. the absorbed dose, of the mixed radiation in the tissue as an average. The factors determining the biological effect are not only the average energy deposited in the irradiated organ or tissue (absorbed dose), but more importantly the distribution of the energy deposition in time and in microscopic space, which is the micro-dose. Considering that cells are the most basic building blocks of the human body, it is important to develop cell and sub-cell scale microdosing studies.
The traditional measurement method of the tissue equivalent proportional counter has the defects of low spatial resolution, capability of simulating only a single cell, obvious wall effect, complicated air supply device, high pressure offset and the like in micro-dose measurement, so that the traditional measurement method of the tissue equivalent proportional counter only can be used for laboratory calibration and severely limits the development of micro-dose science. The silicon-based array micro-dose measuring method developed later has the advantages of high spatial resolution, quick response, strong output signal, capability of simulating a cell array and the like, but the flow sheet manufacturing cost is high, the flow sheet is only a laboratory product at present, more research is focused on the simulation aspect, and a long way is left for practical application. Therefore, there is a need for a new method to measure microdose related quantities
Disclosure of Invention
In view of the defects in the prior art, the present invention aims to provide a scintillator-based micro-dose measurement method and apparatus, which can perform micro-dose measurement using only a scintillator material and an imaging unit.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a scintillator-based micro-dosimetry method comprising the steps of:
a) processing the scintillator material into a square scintillator detector with the thickness of tens of microns to tens of microns;
b) bombarding the scintillator detector in the step a) by particles to generate scintillation light;
c) shooting the signal-enhanced scintillation plane light distribution by using an imaging unit;
d) and calibrating the scintillation light, and each pixel in the output image represents a dose equivalent value in one sensitive unit.
Meanwhile, the invention also provides a measuring device for realizing the scintillator-based micro-dosage measuring method, which comprises the following steps:
a radioactive source;
a scintillator sheet disposed below the radiation source;
a lens disposed below the scintillator sheet;
a steering mirror disposed right below the lens for converting the vertically downward transmitted flare light into a horizontally transmitted flare light;
the image intensifier is horizontally arranged;
and an imaging unit disposed downstream of the image intensifier, for receiving the scintillation light intensified by the image intensifier and forming a scintillation light image.
In some embodiments, the scintillator sheet has a thickness of between ten and several microns and several tens microns.
In some embodiments, a lens is further disposed between the turning mirror and the image intensifier.
In some embodiments, a lens is further disposed between the image intensifier and the imaging unit.
The invention has the following effects: with the method of the present invention, micro-dose measurements can be achieved using only scintillator material and imaging unit.
Drawings
FIG. 1 is a schematic diagram of the structural principle of a scintillator-based micro-dose measuring device according to the present invention.
In the figure:
11-radiation source, 12-scintillator sheet, 13-lens, 14-steering mirror, 15-image intensifier, 16-imaging unit, 17-scintillation light image, 18-dose equivalent distribution.
Detailed Description
The invention is described in further detail below with reference to the drawings and the detailed description.
First, the present embodiment provides a micro-dose measurement method based on a scintillator, including the following steps:
a) processing the scintillator material into a square scintillator detector with the thickness of tens of microns to tens of microns;
b) bombarding the scintillator detector in the step a) by particles to generate scintillation light;
c) shooting the signal-enhanced scintillation plane light distribution by using an imaging unit;
d) and calibrating the scintillation light, and each pixel in the output image represents a dose equivalent value in one sensitive unit.
Meanwhile, referring to fig. 1, the present embodiment also provides a measuring apparatus for implementing the scintillator-based micro-dose measuring method described above, and the measuring apparatus includes a radiation source 11, a scintillator sheet 12, a lens 13, a turning mirror 14, an image intensifier 15, an imaging unit 16, a scintillation light image (local magnification) 17, and a dose equivalent distribution (local magnification) 18.
A scintillator sheet is placed in the incident direction of a radioactive source, particle bombardment generates scintillation light, and scintillation light signals are transmitted to an imaging unit through a lens, a steering mirror, an image intensifier and the like and are recorded by a photosensitive chip. And calibrating the recorded flare light to realize conversion of the flare light to dose equivalent.
The imaging unit 16 used in this embodiment is a cmos camera, and has a pixel size of 6.5 μm and pixel arrangement of 2048 × 2048. The cell diameter of human tissue is generally 10-30 μm, and the cell size is assumed to be 10 μm in this embodiment, so the scintillator sheet 12 is designed to be processed into a square of 1cm × 1cm, representing a cell array of 1000 × 1000, and can be imaged on the camera photosensitive chip. The parameters of the lens in the optical path are adjusted to make the magnification of the whole optical path be 0.65 times, so that the actual size represented by each pixel in the scintillation light image is 10 μm, namely the size of one cell. After the scintillation light signal reaches the imaging unit 16 through the image intensifier 15, a scintillation light brightness distribution image 17 can be obtained, and finally, through a calibration relation between scintillation light brightness and actual dose equivalent, a distribution 18 of dose equivalent on a microscopic scale is given.
The sCMOS camera can give an imaging result of the scintillation light distribution of the whole scintillator sheet, so that the distribution of the micro-dose in space can be easily obtained. The variation of the micro-dose distribution with time can be obtained by changing the exposure time of the sCMOS camera.
In summary, compared with a silicon-based microdosing method and a tissue equivalent proportional counter measuring method, the scintillator-based microdosing method is a measuring method with a simpler structure and a simpler process.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.
Claims (5)
1. A scintillator-based micro-dosimetry method, comprising the steps of:
a) processing the scintillator material into a square scintillator detector with the thickness of tens of microns to tens of microns;
b) bombarding the scintillator detector in the step a) by particles to generate scintillation light;
c) shooting the signal-enhanced scintillation plane light distribution by using an imaging unit;
d) and calibrating the scintillation light, and each pixel in the output image represents a dose equivalent value in one sensitive unit.
2. A measuring device for implementing a scintillator-based micro-dosimetry method according to claim 1, wherein the measuring device comprises:
a radioactive source;
a scintillator sheet disposed below the radiation source;
a lens disposed below the scintillator sheet;
a steering mirror disposed right below the lens for converting the vertically downward transmitted flare light into a horizontally transmitted flare light;
the image intensifier is horizontally arranged;
and an imaging unit disposed downstream of the image intensifier, for receiving the scintillation light intensified by the image intensifier and forming a scintillation light image.
3. The scintillator-based dosimetry device of claim 2, wherein said scintillator sheet has a thickness of between ten and several micrometers and several tens of micrometers.
4. The scintillator-based dosimetry device of claim 3, wherein a lens is further disposed between the turning mirror and the image intensifier.
5. The scintillator-based dosimetry device of claim 4, wherein a lens is further disposed between the image intensifier and the imaging unit.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406686A (en) * | 2021-06-16 | 2021-09-17 | 中国科学院近代物理研究所 | Ion beam three-dimensional dose distribution detection device and method |
| CN117452469A (en) * | 2023-12-26 | 2024-01-26 | 山东大学 | Intracellular radiation micro-dose detection structure and detection method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406686A (en) * | 2021-06-16 | 2021-09-17 | 中国科学院近代物理研究所 | Ion beam three-dimensional dose distribution detection device and method |
| CN117452469A (en) * | 2023-12-26 | 2024-01-26 | 山东大学 | Intracellular radiation micro-dose detection structure and detection method |
| CN117452469B (en) * | 2023-12-26 | 2024-03-19 | 山东大学 | Intracellular radiation micro-dose detection structure and detection method |
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