CN111974311A

CN111974311A - Device for producing receptor regulator

Info

Publication number: CN111974311A
Application number: CN201910429718.5A
Authority: CN
Inventors: 周柳琴; 纪安成; 王�锋
Original assignee: Nanjing Kangdexiang Pharmaceutical Technology Co ltd
Current assignee: Nanjing Kangdexiang Pharmaceutical Technology Co ltd
Priority date: 2019-05-22
Filing date: 2019-05-22
Publication date: 2020-11-24

Abstract

The invention discloses a device for producing receptor modulators, which relates to the field of devices for producing receptor modulators and has the technical scheme that: including the charging box, the feed inlet of lining up the charging box upper wall is seted up to the charging box upper wall, it is connected with the first closing plate that runs through the charging box lateral wall to slide on the charging box lateral wall, first closing plate is close to the charging box upper end and distributes, be equipped with the first moving member that makes first closing plate remove on the charging box, a plurality of first discharge openings that link up the charging box diapire are seted up to the charging box diapire, be equipped with on the charging box diapire with first discharge opening confined closure, the charging box diapire is contradicted and is placed subaerial reaction box, can not open reaction vessel, just adds the raw materials smoothly to reaction vessel, reduces during air or other impurity get into reaction vessel, influences product quality.

Description

Device for producing receptor regulator

Technical Field

The present invention relates to the field of devices for producing receptor modulators, and more particularly, it relates to a device for producing receptor modulators.

Background

Fingolimod is a receptor modulator and is mainly used for clinically treating relapsing and remitting multiple sclerosis.

Chinese patent with publication number CN104193626A discloses a preparation method of fingolimod particles, which comprises (a) adding ethyl acetate into a reactor, controlling the temperature to be-5 ℃, the mass ratio of the ethyl acetate to the feeding amount of fingolimod hydrochloride to be 20: 1-32: 1, (b) dissolving fingolimod hydrochloride in ethanol at 35 ℃, the mass ratio of the fingolimod hydrochloride to the ethanol is 1:4, (c) dripping the solution obtained in the step b into the solution obtained in the step a, controlling the stirring speed of the ethyl acetate mixed solution to be 200rpm-300rpm, and controlling the temperature of the mixed solution of the ethyl acetate to be 0-5 ℃ (d) after the dropwise addition is finished, stirring at 0-5 ℃ for crystallization for 2-6 hours, controlling the stirring speed at 200-300 rpm (e), then separating and removing the solvent, and drying the obtained solid at 10-30 ℃ to obtain the fingolimod hydrochloride particles with D90 of 10-20 mu m.

However, in the course of the reaction, when a plurality of production raw materials are added to the reaction vessel, the reaction vessel needs to be opened, which may cause air or other impurities to enter the reaction vessel, affecting the product quality.

Disclosure of Invention

The invention aims to provide a device for producing receptor modulators, which can smoothly add raw materials into a reaction container without opening the reaction container, and reduce the influence of air or other impurities into the reaction container on the product quality.

The technical purpose of the invention is realized by the following technical scheme: a device for producing a receptor regulator comprises a feeding box, wherein the upper wall of the feeding box is provided with a feed inlet which penetrates through the upper wall of the feeding box, the side wall of the feeding box is connected with a first closing plate which penetrates through the side wall of the feeding box in a sliding manner, the first closing plate is distributed close to the upper end of the feeding box, the feeding box is provided with a first moving member which enables the first closing plate to move, the bottom wall of the feeding box is provided with a plurality of first discharge holes which penetrate through the bottom wall of the feeding box, the bottom wall of the feeding box is provided with a closing member which seals the first discharge holes, the bottom wall of the feeding box is butted with a reaction box which is placed on the ground, the butted surface of the reaction box and the bottom wall of the feeding box is provided with a through hole, the inner wall of the through hole is connected with a second closing plate which seals the through hole, the inner wall of, l type fixed plate and charging box fixed connection, be equipped with the driving piece that drive L type fixed plate removed towards the reaction box on the L type fixed plate.

By adopting the technical scheme, the first closing plate moves on the side wall of the charging box through the first moving piece, and raw materials for producing the receptor regulator are added into the charging box from the feeding hole; through the driving piece, the charging box passes the through-hole and stretches into in the reaction box, at this moment, rotates the closure piece to make the raw materials get into the reaction box through first discharge opening in, can reduce air or other impurity like this and get into in the reaction box, influence product quality, in order to satisfy operation requirement.

Preferably, first moving member is including connecting the fixed plate on the charging box lateral wall, the one end that first closing plate is close to the fixed plate is connected with the connecting plate, the spout has been seted up on the fixed plate, be equipped with the slide bar that moves on the spout on the connecting plate, connecting plate upper end threaded connection has the screw rod, screw rod one end is rotated and is connected on the charging box lateral wall, and the other end extends the fixed plate outer wall.

Through adopting above-mentioned technical scheme, rotate the screw rod, drive connecting plate and connect the first shut on the connecting plate and remove along the horizontal direction, can realize that first shut seals or opens the charging box feed inlet to satisfy operation requirement.

Preferably, the closing member includes a rotating drum sleeved in the charging box, the bottom wall of the rotating drum is provided with a plurality of second discharge holes, and the first discharge holes and the second discharge holes are distributed in a staggered manner.

Through adopting above-mentioned technical scheme, when the raw materials is added to the reaction box to needs, rotate the rotary drum for the second discharge opening is just to first discharge opening, and the raw materials in the feed box loops through in second discharge opening, the first discharge opening gets into the reaction box, simple structure, convenient operation.

Preferably, rotate the piece and include that it has the baffle of contradicting on the through-hole pore wall to articulate through the pivot, be equipped with the torsional spring of contradicting the baffle on the through-hole pore wall in the pivot.

By adopting the technical scheme, firstly, when the driving piece is stirred, the bottom wall of the feeding box penetrates through the through hole and abuts against the baffle plate, the baffle plate moves towards the reaction box under the action of the torsion spring, so that the aim that the raw materials in the feeding box smoothly enter the reaction box is fulfilled; second, when need not add the raw materials, stir the driving piece for the charging box removes to the reaction box dorsad, under the effect of torsional spring, baffle automatic re-setting reduces in air or other impurity entering reaction box, influences product quality, in order to satisfy operation requirement.

Preferably, the driving piece includes compression spring, compression spring one end is connected on L type fixed plate lateral wall, and the other end is connected in the reaction box upper end, the shifting chute has been seted up to reaction box lateral wall inside, L type fixed plate one end slides in the shifting chute, L type fixed plate lateral wall is connected with the cable, the one end winding that the charging box was kept away from to the cable has the fixed pulley that makes the charging box remove in the through-hole, the fixed pulley has second rotating electrical machines through rotary rod connection.

Through adopting above-mentioned technical scheme, start the second rotating electrical machines, the fixed pulley rotates, makes the cable drive the charging box and stretches into the reaction box in, under compression spring's effect for the charging box deviates from the reaction box and removes, in order to realize charging box automatic re-setting, stable in structure, the operation of being convenient for.

Preferably, the baffle is equipped with the rubber pad in the one end of keeping away from the torsional spring, the rubber pad is contradicted on the through-hole pore wall.

Through adopting above-mentioned technical scheme, increase the frictional force between baffle and through-hole wall, make the structure more stable.

Preferably, the reaction box lateral wall slides and is connected with the bull stick that stretches into in the reaction box, the bull stick is kept away from torsional spring one side and is distributed, be equipped with the clean piece of clean first discharge opening on the bull stick.

Through adopting above-mentioned technical scheme, because the raw materials in the charging box get into the reaction box through first discharge opening in, long-time first discharge opening probably has remaining raw materials, blocks up first discharge opening, has influenced production speed and efficiency like this, and the cleaning member can reduce to block up, raises the efficiency.

Preferably, the cleaning part includes the fluff that sets up on the bull stick, and when the charging box stretched into the reaction box, the fluff was contradicted on first discharge opening pore wall, be equipped with the second moving member that makes the bull stick remove along the direction of parallel reaction box upper wall on the bull stick.

Through adopting above-mentioned technical scheme, through stirring the second moving member, drive the bull stick and remove along the reaction box horizontal direction for the fluff is contradicted on first discharge opening pore wall, realizes the purpose of clean a plurality of first discharge openings, reduces to block up.

Preferably, the second moving member includes a connecting rod, one end of the connecting rod is fixedly connected to the rotating rod, and the other end of the connecting rod is connected with an air cylinder placed on the ground.

Through adopting above-mentioned technical scheme, when the charging box got into the reaction box in, through starting the cylinder, the connecting rod drove the bull stick and removes along the reaction box horizontal direction for the fluff of connecting at the bull stick removes between a plurality of first discharge openings of reaction box diapire, realizes the purpose of clean a plurality of first discharge openings, reduces and blocks up.

Preferably, one end of the screw rod extending out of the outer wall of the fixing plate is provided with a first rotating motor.

Through adopting above-mentioned technical scheme, start first rotating electrical machines, make the screw rod rotatory to drive connecting plate and connect the first shut plate horizontal migration on the connecting plate, use manpower sparingly, in order to satisfy operation requirement.

In conclusion, the invention achieves the following beneficial effects: firstly, air or other impurities entering a reaction box are reduced, and the influence on the product quality is reduced, so that the use requirement is met; secondly, the purpose of cleaning a plurality of first discharge holes is realized, and the blockage is reduced; thirdly, the structure is simple, the operation is convenient, and the resources are saved.

Drawings

FIG. 1 is a schematic structural diagram of an L-shaped fixing plate according to the present embodiment;

FIG. 2 is a schematic structural view for embodying the feed tank and the reaction tank of the present embodiment;

FIG. 3 is a schematic structural diagram of the screw rod shown in FIG. 1 according to the present embodiment;

FIG. 4 is an enlarged view of the structure embodying the embodiment A;

FIG. 5 is a schematic structural diagram of the present embodiment for embodying the rotating shaft;

fig. 6 is a schematic structural view of the cleaning member embodying this embodiment.

In the figure: 1. a feed box; 2. a feed inlet; 3. a first closing plate; 4. a first discharge hole; 5. a reaction box; 6. a through hole; 7. an L-shaped fixing plate; 8. a fixing plate; 9. a connecting plate; 10. a chute; 11. a slide bar; 12. a screw; 13. a rotating drum; 14. a second discharge hole; 15. a compression spring; 16. a cable; 17. a fixed pulley; 18. a rubber pad; 19. a rotating rod; 20. softening the wool; 21. a connecting rod; 22. a cylinder; 23. a first rotating electrical machine; 24. a rotating shaft; 25. a torsion spring; 26. a baffle plate; 27. a moving groove; 28. a second rotating electrical machine.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

The technical purpose of the invention is realized by the following technical scheme:

a device for producing a receptor regulator is shown in figure 1 and figure 2, and comprises a feed box 1, wherein the upper wall of the feed box 1 is provided with a feed inlet 2 penetrating through the upper wall of the feed box 1, the side wall of the feed box 1 is connected with a first closing plate 3 penetrating through the side wall of the feed box 1 in a sliding manner, the first closing plate 3 is distributed near the upper end of the feed box 1, the feed box 1 is provided with a first moving member for moving the first closing plate 3, the bottom wall of the feed box 1 is provided with a plurality of first discharge holes 4 penetrating through the bottom wall of the feed box 1, the bottom wall of the feed box 1 is provided with a closing member for closing the first discharge holes 4, the bottom wall of the feed box 1 is abutted with a reaction box 5 placed on the ground, the abutting surface of the reaction box 5 and the bottom wall of the feed box 1 is provided with a through hole 6, the inner wall of the through hole 6 is connected with a second closing plate for closing the through hole 6, the rotating member for, the L-shaped fixing plate 7 is fixedly connected with the feeding box 1, a driving piece for driving the L-shaped fixing plate 7 to move towards the reaction box 5 is arranged on the L-shaped fixing plate 7, the first closing plate 3 is enabled to move on the side wall of the feeding box 1 through the first moving piece, and raw materials for producing the receptor regulator are added into the feeding box 1 from the feeding hole 2; through the driving piece, the charging box 1 passes through the through hole 6 and stretches into the reaction box 5, at this moment, rotates the closing member to make the raw materials pass through in first discharge opening 4 gets into the reaction box 5, can reduce air or other impurity entering reaction box 5 like this in, influence product quality, in order to satisfy operation requirement.

As shown in fig. 1, as shown in fig. 2, the driving member includes compression spring 15, compression spring 15 one end is connected on the lateral wall of L type fixed plate 7, the other end is connected in reaction box 5 upper end, the inside shifting chute 27 that has seted up of reaction box 5 lateral wall, the one end of L type fixed plate 7 slides in shifting chute 27, L type fixed plate 7 lateral wall is connected with cable 16, cable 16 keeps away from the one end winding of charging box 1 and has made charging box 1 move in through-hole 6 fixed pulley 17, fixed pulley 17 has second rotating electrical machines 28 through swivelling joint, start second rotating electrical machines 28, fixed pulley 17 rotates, make cable 16 drive charging box 1 stretch into in the reaction box 5, under compression spring 15's effect, make charging box 1 deviate from reaction box 5 and remove, in order to realize charging box 1 automatic re-setting, and stable in structure, and convenient for operation.

As shown in fig. 3, the first moving member includes a fixed plate 8 connected to the side wall of the charging box 1, one end of the first closing plate 3 close to the fixed plate 8 is connected to a connecting plate 9, a sliding groove 10 is formed in the fixed plate 8, a sliding rod 11 moving on the sliding groove 10 is arranged on the connecting plate 9, a screw rod 12 is connected to the upper end of the connecting plate 9 in a threaded manner, one end of the screw rod 12 is rotatably connected to the side wall of the charging box 1, the outer wall of the fixed plate 8 extends out of the other end of the screw rod, a first rotating motor 23 is arranged at one end of the screw rod 12 extending out of the outer wall of the fixed plate 8, the first rotating motor 23 is started, the screw rod 12 is rotated, the connecting plate 9 and the first closing plate 3 connected to.

As shown in fig. 4, the closing member includes a rotating cylinder 13 sleeved in the charging box 1, a plurality of second discharge holes 14 are formed in the bottom wall of the rotating cylinder 13, the first discharge holes 4 and the second discharge holes 14 are distributed in a staggered manner, when the raw material is required to be added into the reaction box 5, the rotating cylinder 13 is rotated, so that the second discharge holes 14 are right aligned to the first discharge holes 4, the raw material in the charging box 1 sequentially passes through the second discharge holes 14 and the first discharge holes 4 to enter the reaction box 5, the structure is simple, and the operation is convenient.

As shown in fig. 2 and fig. 5, the rotating member includes a baffle 26 hinged to the wall of the through hole 6 through a rotating shaft 24, the rotating shaft 24 is provided with a torsion spring 25 for abutting the baffle 26 against the wall of the through hole 6, when the driving member is shifted, the bottom wall of the feeding box 1 passes through the through hole 6 and the bottom wall of the feeding box 1 abuts against the baffle 26, the baffle 26 moves towards the reaction box 5 under the action of the torsion spring 25, so as to achieve the purpose that the raw material in the feeding box 1 smoothly enters the reaction box 5; when adding the raw materials and finishing, stir the driving piece for charging box 1 removes to reaction box 5 dorsad, under torsional spring 25's effect, baffle 26 automatic re-setting reduces during air or other impurity get into reaction box 5, and in addition, the one end that torsional spring 25 was kept away from to baffle 26 is equipped with rubber pad 18, and rubber pad 18 contradicts on 6 pore walls of through-hole, increases the frictional force between

baffle

26 and 6 pore walls of through-hole, makes the structure more stable.

Like fig. 6, because the raw materials in the charging box 1 get into the reaction box 5 through first discharge opening 4, long-time first discharge opening 4 can have remaining raw materials, block up first discharge opening 4, the production speed and efficiency have been influenced like this, the cleaning member can reduce the jam, and the lifting efficiency, so, 5 lateral wall threaded connection of reaction box has the bull stick 19 that stretches into in the reaction box 5, the bull stick 19 is far away from torsional spring 25 one side and is distributed, be equipped with the cleaning member of clean first discharge opening 4 on the bull stick 19.

As shown in figure 6, the cleaning piece comprises a soft hair 20 arranged on a rotating rod 19, when the charging box 1 extends into the reaction box 5, one end of a baffle 26 is not contacted with the rotating rod 19, the soft hair 20 is abutted on the wall of the first discharging hole 4, and a second moving piece which enables the rotating rod 19 to move along the horizontal direction of the reaction box 5 is arranged on the rotating rod 19.

As figure 6, the second moving member includes connecting rod 21, connecting rod 21 one end fixed connection is on bull stick 19, the other end is connected with places cylinder 22 subaerial, when charging box 1 gets into reaction box 5 in, through starting cylinder 22, connecting rod 21 drives bull stick 19 and removes along reaction box 5 horizontal direction for the fluff 20 of connection at bull stick 19 moves between a plurality of first discharge openings 4 of reaction box 5 diapire, realize the purpose of clean a plurality of first discharge openings 4, reduce and block up.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. A device for producing a receptor modulator, comprising: comprises a feed box (1), wherein the upper wall of the feed box (1) is provided with a feed inlet (2) penetrating through the upper wall of the feed box (1), the side wall of the feed box (1) is connected with a first closing plate (3) penetrating through the side wall of the feed box (1) in a sliding manner, the first closing plate (3) is distributed near the upper end of the feed box (1), the feed box (1) is provided with a first moving member for moving the first closing plate (3), the bottom wall of the feed box (1) is provided with a plurality of first discharge holes (4) penetrating through the bottom wall of the feed box (1), the bottom wall of the feed box (1) is provided with a closed member for closing the first discharge holes (4), the bottom wall of the feed box (1) is abutted against a reaction box (5) for placing on the ground, the abutting surface of the reaction box (5) and the bottom wall of the feed box (1) is provided with a through hole (6), the inner wall of the through hole (6), be equipped with on through-hole (6) inner wall and make second closing plate pivoted rotate the piece, L type fixed plate (7) of fixing in reaction box (5) upper end are worn to be equipped with in charging box (1), L type fixed plate (7) and charging box (1) fixed connection, be equipped with the driving piece that drive L type fixed plate (7) removed towards reaction box (5) on L type fixed plate (7).

2. The device of claim 1 for producing a receptor modulator, wherein: first moving member is including connecting fixed plate (8) on charging box (1) lateral wall, the one end that first closing plate (3) are close to fixed plate (8) is connected with connecting plate (9), spout (10) have been seted up on fixed plate (8), be equipped with slide bar (11) that move on spout (10) on connecting plate (9), threaded connection has screw rod (12) on connecting plate (9), screw rod (12) one end is rotated and is connected on charging box (1) lateral wall, and fixed plate (8) outer wall is extended to the other end.

3. The device of claim 1 for producing a receptor modulator, wherein: the sealing piece comprises a rotary drum (13) sleeved in the charging box (1), a plurality of second discharge holes (14) are formed in the bottom wall of the rotary drum (13), and the first discharge holes (4) and the second discharge holes (14) are distributed in a staggered mode.

4. The device of claim 1 for producing a receptor modulator, wherein: the rotating part comprises a baffle (26) which is hinged to the wall of the through hole (6) through a rotating shaft (24), and a torsion spring (25) which is used for butting the baffle (26) to the wall of the through hole (6) is arranged on the rotating shaft (24).

5. The device of claim 1 for producing a receptor modulator, wherein: the driving piece includes compression spring (15), compression spring (15) one end is connected on L type fixed plate (7) lateral wall, and the other end is connected in reaction box (5) upper end, inside shifting chute (27) of having seted up of reaction box (5) lateral wall, L type fixed plate (7) slide in shifting chute (27), L type fixed plate (7) lateral wall is connected with cable (16), the one end winding that feed box (1) was kept away from in cable (16) has fixed pulley (17) that makes feed box (1) remove in through-hole (6), fixed pulley (17) have second rotating electrical machines (28) through rotary rod connection.

6. The device of claim 4, wherein: one end, far away from the torsion spring (25), of the baffle (26) is provided with a rubber pad (18), and the rubber pad (18) abuts against the wall of the through hole (6).

7. The device for producing a receptor modulator according to claim 1 or 4, wherein: the utility model discloses a reactor, including reaction box (5), torsion spring (25), runner (19), swivel bar (19), the cleaning piece that is equipped with clean first discharge opening (4) on runner (19), the runner (19) lateral wall slides and is connected with runner (19) that stretch into in reaction box (5).

8. The apparatus of claim 7 for producing a receptor modulator, wherein: the cleaning piece is including setting up fluff (20) on bull stick (19), when charging box (1) stretches into reaction box (5), fluff (20) are contradicted on first discharge opening (4) pore wall, be equipped with the second moving member that makes bull stick (19) remove along the direction of parallel reaction box (5) upper wall on bull stick (19).

9. The apparatus for producing a receptor modulator according to claim 8 wherein: the second moving part comprises a connecting rod (21), one end of the connecting rod (21) is fixedly connected to the rotating rod (19), and the other end of the connecting rod is connected with a cylinder (22) placed on the ground.

10. The device of claim 1 for producing a receptor modulator, wherein: and a first rotating motor (23) is arranged at one end of the screw rod (12) extending out of the outer wall of the fixing plate (8).