CN111956749A - 一种治疗和预防痛风的药物及其制备方法 - Google Patents
一种治疗和预防痛风的药物及其制备方法 Download PDFInfo
- Publication number
- CN111956749A CN111956749A CN202011013054.3A CN202011013054A CN111956749A CN 111956749 A CN111956749 A CN 111956749A CN 202011013054 A CN202011013054 A CN 202011013054A CN 111956749 A CN111956749 A CN 111956749A
- Authority
- CN
- China
- Prior art keywords
- treating
- medicine
- medicament
- water
- preventing gout
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 201000005569 Gout Diseases 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 229940079593 drug Drugs 0.000 title description 5
- 239000008187 granular material Substances 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 18
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 18
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 18
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 18
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 18
- 235000011477 liquorice Nutrition 0.000 claims abstract description 18
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 16
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 16
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 16
- 239000004863 Frankincense Substances 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 14
- 241000167854 Bourreria succulenta Species 0.000 claims abstract description 12
- 244000119298 Emblica officinalis Species 0.000 claims abstract description 12
- 235000015489 Emblica officinalis Nutrition 0.000 claims abstract description 12
- 240000008042 Zea mays Species 0.000 claims abstract description 12
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 12
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 12
- 239000002775 capsule Substances 0.000 claims abstract description 12
- 235000019693 cherries Nutrition 0.000 claims abstract description 12
- 235000005822 corn Nutrition 0.000 claims abstract description 12
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 11
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 11
- 235000012907 honey Nutrition 0.000 claims abstract description 8
- 241000218671 Ephedra Species 0.000 claims abstract description 6
- 235000011517 Terminalia chebula Nutrition 0.000 claims abstract description 6
- 241000001522 Terminalia chebula Species 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 55
- 239000012535 impurity Substances 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 244000272264 Saussurea lappa Species 0.000 claims description 7
- 235000006784 Saussurea lappa Nutrition 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000000428 dust Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000004576 sand Substances 0.000 claims description 4
- 240000004507 Abelmoschus esculentus Species 0.000 claims description 3
- 235000003934 Abelmoschus esculentus Nutrition 0.000 claims description 3
- 240000005959 Abelmoschus manihot Species 0.000 claims description 3
- 235000001075 Abelmoschus manihot Nutrition 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- -1 drying Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 5
- 239000009609 fructus phyllanthi Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 208000002193 Pain Diseases 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000001105 regulatory effect Effects 0.000 abstract description 5
- 241001075517 Abelmoschus Species 0.000 abstract description 4
- 240000004584 Tamarindus indica Species 0.000 abstract description 4
- 235000004298 Tamarindus indica Nutrition 0.000 abstract description 4
- 239000002893 slag Substances 0.000 abstract description 4
- 244000116484 Inula helenium Species 0.000 abstract description 3
- 235000002598 Inula helenium Nutrition 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 3
- 235000001014 amino acid Nutrition 0.000 abstract description 3
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 3
- 235000010755 mineral Nutrition 0.000 abstract description 3
- 239000011707 mineral Substances 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 239000011573 trace mineral Substances 0.000 abstract description 3
- 235000013619 trace mineral Nutrition 0.000 abstract description 3
- 235000013343 vitamin Nutrition 0.000 abstract description 3
- 239000011782 vitamin Substances 0.000 abstract description 3
- 229940088594 vitamin Drugs 0.000 abstract description 3
- 229930003231 vitamin Natural products 0.000 abstract description 3
- 229940126673 western medicines Drugs 0.000 abstract description 3
- 241001465251 Ephedra sinica Species 0.000 abstract description 2
- 241001278833 Rosa laevigata Species 0.000 abstract description 2
- 235000000661 Rosa laevigata Nutrition 0.000 abstract description 2
- 230000036772 blood pressure Effects 0.000 abstract description 2
- 230000007721 medicinal effect Effects 0.000 abstract description 2
- 229940023569 palmate Drugs 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 240000000982 Malva neglecta Species 0.000 abstract 1
- 235000000060 Malva neglecta Nutrition 0.000 abstract 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 4
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 4
- 229940116269 uric acid Drugs 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 2
- 201000001431 Hyperuricemia Diseases 0.000 description 2
- 229920000175 Pistacia lentiscus Polymers 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗和预防痛风的药物及其制备方法，包括12克乳香、12克没药、12克木香、24克车厘子、9克毛诃子、9克决明子、12克余甘子、12克玉米须、9克黄葵子、9克渣驯膏、24克巴夏嘎、6克麻黄、9克甘草和0.3克藏蜜。本药物由乳香、没药、木香、车厘子、毛诃子、决明子、余甘子、玉米须、黄葵子、渣驯膏、巴夏嘎、麻黄、甘草和藏蜜熬制而成，相对西药来说其药效温和，对身体的刺激较小，具有调气活血、止痛定痛、解热清毒、调节血压的功效，并且含多种维生素、矿物质、氨基酸、以及微量元素；本发明将传统的中药煎煮出的药液，通过添加辅料，使药液制成颗粒剂或胶囊剂，既保存了药液所原有的药性，又使其延长了存放的时间，并且便于保存。
Description
技术领域
本发明涉及一种治疗和预防痛风的药物，具体是一种治疗和预防痛风的药物及其制备方法，属于制药技术领域。
背景技术
痛风又称“高尿酸血症”，嘌呤代谢障碍，属于关节炎一种，各个年龄段均可能罹患本病，男性发病率高于女性，痛风是人体内嘌呤的物质的新陈代谢发生紊乱，尿酸的合成增加或排出减少，造成高尿酸血症，血尿酸浓度过高时，尿酸以钠盐的形式沉积在关节、软骨和肾脏中，引起组织异物炎性反应，即痛风，多数患者发作前无明显征兆，或仅有疲乏、全身不适和关节刺痛等，典型发作常于深夜因关节痛而惊醒，疼痛进行性加剧，在十二小时左右达高峰，呈撕裂样、刀割样或咬噬样，难以忍受，受累关节及周围组织红、肿、热、痛和功能受限，目前痛风治疗主要是根据临床症状针对给药，主要是在发作期吃秋水仙碱加止痛药，以便快速消炎，解除痛苦，间歇期吃别嘌呤等药物降低尿酸，预防再次发作，基本上，目前痛风所用西药都具有严重的副作用，而且治标不治本，因此，人们对有效治疗痛风的中药存在极大的需求，因此一种治疗和预防痛风的药物被研制出来。
西医治疗痛风存在容易复发，治疗效果较差，且对身体刺激较大的问题，而传统的中医中药疗法又存在周期长，保存不便的问题，因此本发明提供一种治疗效果高，且保存时间较长的一种治疗和预防痛风的药物及其制备方法。
发明内容
本发明的目的就在于为了解决上述问题而提供一种治疗和预防痛风的药物及其制备方法。
本发明通过以下技术方案来实现上述目的，一种治疗和预防痛风的药物，以重量计，所述药物配方包括12克乳香、12克没药、12克木香、24克车厘子、9克毛诃子、9克决明子、12克余甘子、12克玉米须、9克黄葵子、9克渣驯膏、24克巴夏嘎、6克麻黄、9克甘草和0.3克藏蜜。
优选的，所述乳香和所述没药除去砂子杂质，所述乳香和所述没药混合后打成碎块。
优选的，所述木香拣去杂质，用清水洗净，切成小丝，晒干，所述余甘子取其树根和叶，拣去杂质，用水洗净，捞出，切片或切丝，晒干。
优选的，所述车厘子去核，用清水洗净，切片晒干，所述决明子除去杂质，用清水洗净后干燥。
优选的，所述毛诃子和所述巴夏嘎均除去杂质后晒干。
优选的，所述玉米须和所述黄葵子均用清水洗净后晒干。
优选的，所述麻黄拣去杂质，去尽木质茎及残根，用水洗净，切段后干燥。
优选的，所述甘草拣去杂质，洗净后放置在清水中水浸泡，浸泡至八成透时捞出，切片晒干。
优选的，所述的一种治疗和预防痛风的药物得出一种治疗和预防痛风的药物的制备方法，所述制备方法包括如下步骤：
第一步，将上述原料拣去杂质和粉尘后，按照重量碾碎成颗粒状，用两层干净纱布包裹成药包，选用瓦罐或砂锅，向内加入500克至600克冷开水，将药包浸泡在冷开水中30分钟至35分钟，然后进行初次煎煮，初次煎煮时先用武火，待水煮沸后改文火煮20分钟至30分钟，然后将药液滤出；
第二步，再向瓦罐或砂锅加入400克至500克冷开水，然后进行二次煎煮，二次煎煮时同样先用武火，待水煮沸后改文火煮10分钟至15分钟，滤取药液，将二次滤出的药液混合后进行浓缩，将药液浓缩成膏状，然后干燥后备用；
第三步，制胶囊剂或制颗粒剂，将研磨好的药膏粉末过筛后，加入适量的制胶囊辅料混合均匀，然后制备成胶囊剂，制成颗粒，将研磨好的药膏粉末过筛后，加入制粒辅料，干燥后整粒，制粒，制得颗粒剂。
优选的，所述制囊辅料包括微粉硅胶、微晶纤维素和淀粉，所述制粒辅料包括糊精和乙醇。
本发明的有益效果是：
(1)本药物由乳香、没药、木香、车厘子、毛诃子、决明子、余甘子、玉米须、黄葵子、渣驯膏、巴夏嘎、麻黄、甘草和藏蜜熬制而成，相对西药来说其药效温和，对身体的刺激较小，具有调气活血、止痛定痛、解热清毒、调节血压的功效，并且含多种维生素、矿物质、氨基酸、以及微量元素；
(2)本发明将传统的中药煎煮出的药液，通过添加辅料，使药液制成颗粒剂或胶囊剂，既保存了药液所原有的药性，又使其延长了存放的时间，并且便于保存。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其它的附图。
图1为本发明的方法流程图。
具体实施方式
为使得本发明的发明目的、特征、优点能够更加的明显和易懂，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，下面所描述的实施例仅仅是本发明一部分实施例，而非全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例一：
一种治疗和预防痛风的药物，以重量计，所述药物配方包括12克乳香、12克没药、12克木香、24克车厘子、9克毛诃子、9克决明子、12克余甘子、12克玉米须、9克黄葵子、9克渣驯膏、24克巴夏嘎、6克麻黄、9克甘草和0.3克藏蜜。
具体的，所述乳香和所述没药除去砂子杂质，所述乳香和所述没药混合后打成碎块。
具体的，所述木香拣去杂质，用清水洗净，切成小丝，晒干，所述余甘子取其树根和叶，拣去杂质，用水洗净，捞出，切片或切丝，晒干。
具体的，所述车厘子去核，用清水洗净，切片晒干，所述决明子除去杂质，用清水洗净后干燥。
具体的，所述毛诃子和所述巴夏嘎均除去杂质后晒干。
具体的，所述玉米须和所述黄葵子均用清水洗净后晒干。
具体的，所述麻黄拣去杂质，去尽木质茎及残根，用水洗净，切段后干燥。
具体的，所述甘草拣去杂质，洗净后放置在清水中水浸泡，浸泡至八成透时捞出，切片晒干。
具体的，所述的一种治疗和预防痛风的药物得出一种治疗和预防痛风的药物的制备方法，所述制备方法包括如下步骤：
第一步，将上述原料拣去杂质和粉尘后，按照重量碾碎成颗粒状，用两层干净纱布包裹成药包，选用瓦罐或砂锅，向内加入500克至600克冷开水，将药包浸泡在冷开水中30分钟至35分钟，然后进行初次煎煮，初次煎煮时先用武火，待水煮沸后改文火煮20分钟至30分钟，然后将药液滤出；
第二步，再向瓦罐或砂锅加入400克至500克冷开水，然后进行二次煎煮，二次煎煮时同样先用武火，待水煮沸后改文火煮10分钟至15分钟，滤取药液，将二次滤出的药液混合后进行浓缩，将药液浓缩成膏状，然后干燥后备用；
第三步，制胶囊剂，将药膏研磨成细粉，过筛后加入适量的制胶囊辅料混合均匀，然后制备成胶囊剂。
具体的，所述制囊辅料包括微粉硅胶、微晶纤维素和淀粉。
上述方法适用于胶囊剂的制备。
实施例二：
一种治疗和预防痛风的药物，以重量计，所述药物配方包括12克乳香、12克没药、12克木香、24克车厘子、9克毛诃子、9克决明子、12克余甘子、12克玉米须、9克黄葵子、9克渣驯膏、24克巴夏嘎、6克麻黄、9克甘草和0.3克藏蜜。
具体的，所述乳香和所述没药除去砂子杂质，所述乳香和所述没药混合后打成碎块。
具体的，所述木香拣去杂质，用清水洗净，切成小丝，晒干，所述余甘子取其树根和叶，拣去杂质，用水洗净，捞出，切片或切丝，晒干。
具体的，所述车厘子去核，用清水洗净，切片晒干，所述决明子除去杂质，用清水洗净后干燥。
具体的，所述毛诃子和所述巴夏嘎均除去杂质后晒干。
具体的，所述玉米须和所述黄葵子均用清水洗净后晒干。
具体的，所述麻黄拣去杂质，去尽木质茎及残根，用水洗净，切段后干燥。
具体的，所述甘草拣去杂质，洗净后放置在清水中水浸泡，浸泡至八成透时捞出，切片晒干。
具体的，所述的一种治疗和预防痛风的药物得出一种治疗和预防痛风的药物的制备方法，所述制备方法包括如下步骤：
第一步，将上述原料拣去杂质和粉尘后，按照重量碾碎成颗粒状，用两层干净纱布包裹成药包，选用瓦罐或砂锅，向内加入500克至600克冷开水，将药包浸泡在冷开水中30分钟至35分钟，然后进行初次煎煮，初次煎煮时先用武火，待水煮沸后改文火煮20分钟至30分钟，然后将药液滤出；
第二步，再向瓦罐或砂锅加入400克至500克冷开水，然后进行二次煎煮，二次煎煮时同样先用武火，待水煮沸后改文火煮10分钟至15分钟，滤取药液，将二次滤出的药液混合后进行浓缩，将药液浓缩成膏状，然后干燥后备用；
第三步，制颗粒剂，将药膏研磨成粒径范围在105微米至500微米的颗粒，过筛后加入适量的制胶囊辅料混合均匀，干燥后整粒，制粒，制得颗粒剂。
具体的，所述制粒辅料包括糊精和乙醇。
上述方法适用于颗粒剂的制备。
上述药物配方中，乳香和没药均为树脂类药物，且乳香和没药的功效基本相似，具有调气活血、定痛的功效，能够使身体活血化瘀，木香具有行气、止痛、健脾、消食的功效，余甘子能解热清毒，治皮炎、湿疹、风湿痛等，玉米须有利尿消肿，清肝利胆的功效，甘草和毛诃子不仅能够清热解毒，还能调和诸药，而藏蜜富含多种维生素、矿物质、氨基酸、酶类、叶酸以及微量元素和生物活性物质。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的得同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。
以上所述，以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (10)
1.一种治疗和预防痛风的药物，其特征在于：以重量计，所述药物配方包括12克乳香、12克没药、12克木香、24克车厘子、9克毛诃子、9克决明子、12克余甘子、12克玉米须、9克黄葵子、9克渣驯膏、24克巴夏嘎、6克麻黄、9克甘草和0.3克藏蜜。
2.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述乳香和所述没药除去砂子杂质，所述乳香和所述没药混合后打成碎块。
3.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述木香拣去杂质，用清水洗净，切成小丝，晒干，所述余甘子取其树根和叶，拣去杂质，用水洗净，捞出，切片或切丝，晒干。
4.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述车厘子去核，用清水洗净，切片晒干，所述决明子除去杂质，用清水洗净后干燥。
5.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述毛诃子和所述巴夏嘎均除去杂质后晒干。
6.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述玉米须和所述黄葵子均用清水洗净后晒干。
7.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述麻黄拣去杂质，去尽木质茎及残根，用水洗净，切段后干燥。
8.根据权利要求1所述的一种治疗和预防痛风的药物，其特征在于：所述甘草拣去杂质，洗净后放置在清水中水浸泡，浸泡至八成透时捞出，切片晒干。
9.根据权利要求1-8任意一项所述的一种治疗和预防痛风的药物得出一种治疗和预防痛风的药物的制备方法，其特征在于：所述制备方法包括如下步骤：
第一步，将上述原料拣去杂质和粉尘后，按照重量碾碎成颗粒状，用两层干净纱布包裹成药包，选用瓦罐或砂锅，向内加入500克至600克冷开水，将药包浸泡在冷开水中30分钟至35分钟，然后进行初次煎煮，初次煎煮时先用武火，待水煮沸后改文火煮20分钟至30分钟，然后将药液滤出；
第二步，再向瓦罐或砂锅加入400克至500克冷开水，然后进行二次煎煮，二次煎煮时同样先用武火，待水煮沸后改文火煮10分钟至15分钟，滤取药液，将二次滤出的药液混合后进行浓缩，将药液浓缩成膏状，然后干燥后备用；
第三步，制胶囊剂或制颗粒剂，将研磨好的药膏粉末过筛后，加入适量的制胶囊辅料混合均匀，然后制备成胶囊剂，制成颗粒，将研磨好的药膏粉末过筛后，加入制粒辅料，干燥后整粒，制粒，制得颗粒剂。
10.根据权利要求9所述的一种治疗和预防痛风的药物的制备方法，其特征在于：所述制囊辅料包括微粉硅胶、微晶纤维素和淀粉，所述制粒辅料包括糊精和乙醇。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011013054.3A CN111956749A (zh) | 2020-09-24 | 2020-09-24 | 一种治疗和预防痛风的药物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011013054.3A CN111956749A (zh) | 2020-09-24 | 2020-09-24 | 一种治疗和预防痛风的药物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111956749A true CN111956749A (zh) | 2020-11-20 |
Family
ID=73387316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011013054.3A Pending CN111956749A (zh) | 2020-09-24 | 2020-09-24 | 一种治疗和预防痛风的药物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111956749A (zh) |
-
2020
- 2020-09-24 CN CN202011013054.3A patent/CN111956749A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104258045A (zh) | 一种润肠通便的中药及其制备方法 | |
| CN105194538A (zh) | 金黄膏及其制备方法 | |
| CN113952380A (zh) | 一种治疗鼻炎的中药组合物、中药制剂及其制备方法和应用 | |
| CN114470121B (zh) | 一种治疗骨关节炎的药物及其制备方法 | |
| CN102772626B (zh) | 一种消炎解毒灭菌的药物组合物 | |
| CN111956749A (zh) | 一种治疗和预防痛风的药物及其制备方法 | |
| CN113797275A (zh) | 一种治疗急性乳腺炎的中药组合物及制备方法 | |
| CN108030812B (zh) | 一种治疗肾虚型牙齿松浮脱落的中药牙粉及其制备方法 | |
| CN111467456A (zh) | 一种治疗颈椎腰腿疼痛的膏药 | |
| CN105106820A (zh) | 一种应用于老年便秘的中药口服液及制备方法 | |
| CN105079747A (zh) | 手用冻疮膏及其制备方法 | |
| CN103599271B (zh) | 一种治疗子宫肌瘤的中药 | |
| CN107865978B (zh) | 中药卫生保健护垫的制作方法 | |
| CN103751648A (zh) | 用于乳腺增生患者的制品 | |
| CN118416154A (zh) | 中药穴位贴敷剂及其制作方法 | |
| CN106853193A (zh) | 一种治疗类风湿性关节炎的中药及其制备方法 | |
| CN116726111A (zh) | 一种治疗跌打损伤的外用药 | |
| CN105919098A (zh) | 一种用于治疗高血压和慢性便秘的保健品及其制备方法 | |
| CN104873596A (zh) | 治疗湿疹的中药外洗剂 | |
| CN118743733A (zh) | 一种骨刺舒筋药方 | |
| CN112007089A (zh) | 一种治疗肾炎的中药口服液 | |
| CN115364135A (zh) | 一种炎症外治组合物及其制备方法和应用 | |
| CN104306585A (zh) | 一种用于治疗前列腺炎的中药组合物及其制备方法与应用 | |
| CN117323268A (zh) | 一种牙膏以及制备方法 | |
| CN100490834C (zh) | 一种微米鹿茸红花仙子补肾消疲口服液制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201120 |
|
| RJ01 | Rejection of invention patent application after publication |