CN111956192A - OCT (optical coherence tomography) tomography probe, OCT imaging system and imaging method - Google Patents
OCT (optical coherence tomography) tomography probe, OCT imaging system and imaging method Download PDFInfo
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Abstract
The invention discloses an OCT (optical coherence tomography) tomography imaging probe, an OCT imaging system and an imaging method, which comprise components such as an MEMS micro-galvanometer, an optical fiber aggregator, a camera module, a probe base and the like, wherein an optical fiber clamping groove is formed in the probe base to fix the optical fiber aggregator, and the shape of the optical fiber clamping groove is matched with that of the optical fiber aggregator, so that the position and the angle of the optical fiber aggregator are prevented from being influenced by other components, and the stability of image imaging is ensured; the characteristics of miniaturization and large angle of the MEMS micro-galvanometer are utilized, the diameter of the small probe is kept, the structure of the whole probe is simplified as much as possible, and the processing technology of the probe is simplified; the fixing and light transmission effects of the optical fiber gathering device are ensured; adjusting an imaging focal plane through a camera module, and accurately controlling a guide light initial position and an imaging area; the OCT tomography probe can be used for cervical imaging diagnosis, and becomes a medical diagnosis tool with rapidness, no staining, high sensitivity, high specificity and full visual field.
Description
Technical Field
The invention relates to the technical field of OCT imaging, in particular to an OCT tomography probe, an OCT imaging system and an imaging method.
Background
Cervical cancer is a female malignant tumor with the incidence rate of 2 nd, and because the cervical cancer has a long onset period, early treatment can be found early by means of early cervical screening and the like. Medically popular cervical cancer screens are: TCT cytology and HPV virus detection preliminary screening are firstly carried out, colposcopy is carried out on part of suspicious lesion patients, the morphological color of the cervix is observed through a vinegar iodine test, and part of tissues are selected for pathological biopsy to confirm diagnosis. Usually, 12 points around the cervical orifice are selected, and a plurality of suspicious tissues are respectively taken down for pathological detection to obtain a final diagnosis result, which usually needs 3 to 5 days and is a detection process with wounds.
The Optical Coherence Tomography (OCT) is used as a novel medical imaging means, recovers the three-dimensional form of a sample by collecting a reflected light signal of a tissue, reflects important information such as the internal structure, the scattering coefficient and the like of a biological tissue, has the imaging depth of 3-6mm, covers a lesion area, has the resolution of 1-10 mu m, and has the advantages of non-contact, no mark, real-time high-resolution imaging and the like. The OCT imaging system can carry out real-time non-invasive tomography on the cervix before biopsy, and normal tissues and suspicious lesion tissues are distinguished, so that damaged tissue areas of biopsy are reduced.
The existing OCT imaging system has the following defects: (1) for example, patent CN103163111A proposes an early cervical cancer detection system combining fluorescence mesoscopic imaging and OCT, and patent CN111419194A proposes an OCT and fluorescence laser combined imaging device, which is essentially a structural combination and simultaneous imaging of multiple sets of imaging systems, and does not achieve the purpose of simplifying system construction and operation and improving system imaging performance; and the system adopts the mode of light path rear end scanning (namely the scanning mechanism is located at the rear end of the probe), the diameter of the probe is limited by the fact that the light path design cannot be set too large, and the imaging field of view is always smaller than the diameter of the probe, so that the whole cervical region cannot be imaged, point-by-point analysis is needed, multiple detection is needed, the operation is troublesome, and the risk of missed detection exists. (2) For example, patent CN102894947A proposes a MEMS optical probe that can be used for front-end scanning imaging (i.e. the scanning mechanism is located at the front end of the probe), although the front-end scanning imaging can solve the problem that the imaging field of view is too small, the circuit board, the lead wires and the optical fiber path of the optical probe are overlapped (see fig. 6 in the detailed description, all of which are disposed in the cavity 121), and the optical fiber path has no fixed structure, so that there is difficulty in positioning and fixing the optical fiber path and the angle, which causes the imaging field of view to be easily deviated, and affects the stability of image imaging.
Therefore, the prior art still needs to be improved and developed.
Disclosure of Invention
The invention aims to provide an OCT (optical coherence tomography) tomography probe, an OCT imaging system and an imaging method, and aims to solve the problems that an imaging view field is easy to deviate and the imaging stability of an image is influenced because an optical fiber path is not provided with a fixed structure and is difficult to place and fix an angle because a circuit board, a lead and the optical fiber path of the existing MEMS optical probe are overlapped.
The technical scheme of the invention is as follows: an OCT tomography probe comprises a probe base, an optical fiber concentrator and a circuit board, wherein one end face of the probe base is provided with an inclined plane forming a certain angle with a horizontal plane, and the circuit board is fixed on the inclined plane of the probe base; the side surface of the probe base is provided with a first optical fiber clamping groove which penetrates through the whole probe base along the length direction of the probe base, and the shape of the optical fiber clamping groove is matched with that of the optical fiber concentrator; a second optical fiber clamping groove with the shape matched with that of the optical fiber concentrator is formed in the position, corresponding to the first optical fiber clamping groove, of the circuit board; the optical fiber convergence device is fixedly arranged in the first optical fiber clamping groove and the second optical fiber clamping groove.
The OCT tomography probe, wherein, the distance between the both sides of the opening of first fiber-optic draw-in groove is less than the diameter of optical fiber concentrator.
The OCT tomography probe is characterized in that glue is dispensed at a gap between the first optical fiber clamping groove and the optical fiber concentrator.
The OCT tomography probe comprises an electric wire, wherein a side surface installation groove which penetrates through the whole probe base along the length direction of the probe base is formed in the side surface of the probe base, the electric wire is installed in the side surface installation groove, and the electric wire is electrically connected with a circuit board.
The OCT tomography probe is characterized in that a reflecting prism for light path turning is arranged at one end, close to a circuit board, of an optical fiber concentrator, a hollow position for positioning and fixing a substrate is arranged in the middle of the circuit board, the substrate is arranged in the hollow position, and an MEMS micro-galvanometer is arranged on the substrate; the micro-vibration optical fiber spectrometer is characterized by further comprising a shell sleeve, the reflecting prism, the probe base, the optical fiber gathering device, the MEMS micro-vibration mirror and the circuit board are all arranged in the shell sleeve, and a window lens used for transmission and collection of a light path is arranged on one end face, close to the MEMS micro-vibration mirror, of the shell sleeve.
The OCT tomography probe further comprises a camera module which is arranged on the circuit board and used for assisting the OCT system to adjust imaging definition.
The OCT tomography probe is characterized in that a first bonding pad and a welding hole which are used for realizing electric connection of the camera module mirror and a second bonding pad and a welding hole which are used for realizing electric connection of the MEMS micro-vibration mirror are further arranged on the circuit board, the first bonding pad and the welding hole and the second bonding pad and the welding hole are correspondingly arranged with the side mounting groove, and an electric wire is directly electrically connected with the first bonding pad and the welding hole and the second bonding pad and the welding hole after being wired along the side mounting groove.
An OCT imaging system comprising an OCT tomographic imaging probe as described in any one of the above.
A tomography method of the OCT imaging system comprises the following steps:
s1: the light beam emitted by the OCT system is reflected back by the optical fiber concentrator and the reflecting prism and then enters the lens of the MEMS micro-vibrating mirror;
s2: the micro-galvanometer 7 is controlled to realize the vibration of angles in two-dimensional directions, the light beam direction is driven to deflect, the light beam is transmitted to a tested tissue after the secondary amplification of a window lens and a fixed imaging distance, the linear light beam is subjected to one-time clockwise annular surface scanning, the OCT image of the tested tissue is synchronously recorded, and then the OCT three-dimensional data of the tested tissue can be obtained;
s3: and extracting and outputting an accurate position image of a required observation point from the measured tissue OCT three-dimensional data.
The tomography method of the OCT imaging system further comprises the following steps before S1:
s01: light beams emitted by the OCT system and containing visible laser enter a lens of the MEMS micro-vibration mirror through the turning back of the optical fiber collector and the reflecting prism, are deflected by the MEMS micro-vibration mirror, are transmitted to a tested tissue through secondary amplification of the window lens and a fixed imaging distance, and are imaged by the camera module;
s02: adjusting the distance from the OCT tomography probe to the measured tissue to enable the imaging of the camera module to be gradually clear, and realizing the coarse adjustment of the position and the imaging focal plane of the OCT tomography probe;
s03: the driving voltage or the driving current of the MEMS micro-vibrating mirror is controlled to drive the light beam containing the visible laser to perform linear scanning, a straight line can be seen in the imaging of the camera module at the moment, the position of the OCT tomography probe is finely adjusted, the straight line is clear in the imaging of the camera module, the imaging position and the resolution of the OCT system are in the best state at the moment, and the accurate alignment of the scanning starting position and the imaging area is realized.
The invention has the beneficial effects that: the invention provides an OCT (optical coherence tomography) tomography imaging probe, an OCT imaging system and an imaging method, which comprise components such as an MEMS micro-galvanometer, an optical fiber aggregator, a camera module, a probe base and the like, wherein an optical fiber clamping groove is formed in the probe base to fix the optical fiber aggregator, and the shape of the optical fiber clamping groove is matched with that of the optical fiber aggregator, so that the position and the angle of the optical fiber aggregator are prevented from being influenced by other components, and the stability of image imaging is ensured; the characteristics of miniaturization and large angle of the MEMS micro-galvanometer are utilized, the diameter of the small probe is kept, the structure of the whole probe is simplified as much as possible, and the processing technology of the probe is simplified; the fixing and light transmission effects of the optical fiber gathering device are ensured; adjusting an imaging focal plane through a camera module, and accurately controlling a guide light initial position and an imaging area; the OCT tomography probe can be used for cervical imaging diagnosis, and becomes a medical diagnosis tool with rapidness, no staining, high sensitivity, high specificity and full visual field.
Drawings
Fig. 1 to 3 are schematic structural views of an OCT tomographic imaging probe in the present invention.
Fig. 4 is a schematic front view of the circuit board of the present invention.
FIG. 5 is a side schematic view of the probe base of the present invention.
FIG. 6 is a schematic diagram of the optical path of the OCT tomography probe of the invention.
FIG. 7 is a schematic view of a visible laser imaging surface in accordance with the present invention.
FIG. 8 is a flowchart of the steps of the imaging method of the OCT imaging system of the invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; may be mechanically connected, may be electrically connected or may be in communication with each other; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
The following disclosure provides many different embodiments or examples for implementing different features of the invention. To simplify the disclosure of the present invention, the components and arrangements of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or uses of other materials.
As shown in fig. 1 to 5, an OCT tomographic imaging probe, which can be used for general OCT imaging, and is particularly suitable for cervical tomographic OCT imaging, includes a probe base 5, an optical fiber concentrator 4, and a circuit board 9, wherein an end surface of the probe base 5 is disposed as an inclined surface forming a certain angle with a horizontal plane, and the circuit board 9 is fixed on the inclined surface of the probe base 5; a first optical fiber clamping groove 51 penetrating through the whole probe base 5 along the length direction of the probe base 5 is formed in the side surface of the probe base 5, and the shape of the optical fiber clamping groove 51 is matched with that of the optical fiber concentrator 4; a second optical fiber card slot 92 with a shape matched with that of the optical fiber concentrator 4 is arranged at the position of the circuit board 9 corresponding to the first optical fiber card slot 51; the fiber optic aggregator 4 is fixedly disposed within the first fiber slot 51 and the second fiber slot 92.
Because in practical application, a person skilled in the art may find that the optical path of the optical fiber has no fixed structure, and there are difficulties in placement and angle fixation, which results in a problem that the imaging field of view is easily deviated, and the imaging stability of the image is affected, for this technical problem, the person skilled in the art generally makes the following: (1) the fixing parts such as the fixing clip and the fixing seat for fixing the optical fiber concentrator 4 are arranged in the cavity of the probe base, so that the probe structure becomes complicated, the space in the cavity of the probe base is narrow, and the operation is inconvenient; (2) the optical fiber is suspended and fixed in the cavity of the probe base in an adhesive mode and separated from the circuit board and the lead, so that the optical fiber is easy to fall off due to aging of the adhesive after the mode is used for a long time; (3) the convex structure is arranged on the inner wall of the cavity of the probe base to support the optical fiber, and the processing in the mode is more difficult to operate in the narrow cavity of the probe base; and so on. According to the technical scheme, the first optical fiber clamping groove 51 is directly formed in the probe base 5 to fix the optical fiber concentrator 4, so that the optical fiber concentrator 4 is separated from other components to be fixed independently, the influence of other components on the position and the angle of the optical fiber concentrator 4 is avoided, the imaging view field is ensured not to deviate, and the stability of image imaging is ensured; the shape of the first optical fiber clamping groove 51 is matched with that of the optical fiber concentrator 4, so that the fixing effect on the optical fiber concentrator 4 is good; according to the technical scheme, other fixing accessories are not added, the diameter of the small probe is kept, the structure of the whole probe is simplified as much as possible, and the processing technology of the probe is simplified; not only can the fixation of the optical fiber convergence device 4 be ensured, but also the light transmission effect of the optical fiber convergence device 4 can be ensured.
In some embodiments, the distance H between two sides of the opening of the first fiber slot 51 is smaller than the diameter of the fiber concentrator 4, so that when the fiber concentrator 4 is placed in the first fiber slot 51, the first fiber slot 51 can limit the fiber concentrator 4 from separating from the first fiber slot 51, and further ensure the fixing effect of the fiber concentrator 4.
In some embodiments, a glue is dispensed at the gap between the first fiber slot 51 and the fiber concentrator 4 to perform a fixing function, so as to further ensure the fixing effect of the fiber concentrator 4.
In some embodiments, the OCT tomography probe includes the electric wire 11, a side mounting groove 52 is formed on the side of the probe base 5 and penetrates the entire probe base 5 along the length direction of the probe base 5, the electric wire 11 is mounted in the side mounting groove 52, and the electric wire 11 is electrically connected with the circuit board 9. The side surface mounting groove 52 is formed in the side surface of the probe base 5, so that the whole volume of the probe is reduced as much as possible while the electric wire 11 is convenient to route and fix, and the probe can be miniaturized.
In this embodiment, two side mounting grooves 52 are provided, and the two side mounting grooves 52 are symmetrically provided and located at two sides of the first fiber card slot 51 respectively.
Wherein, the inclined plane of probe base 5 and horizontal plane contained angle are about 45.
In some embodiments, a reflecting prism 3 for light path turning back is arranged at one end of the optical fiber concentrator 4 close to the circuit board 9, the middle of the circuit board 9 is hollowed, a substrate 8 is arranged at the hollowed position, and an MEMS micro-vibrating mirror 7 is arranged on the substrate 8.
In this embodiment, the reflecting surface of the reflecting prism 3 forms an included angle of 45 degrees with the horizontal plane, the optical fiber concentrator 4 is used for collimation and focusing of a light path, the reflecting prism 3 is connected with the optical fiber concentrator 4 through optical UV glue, and the optical fiber concentrator 4 is connected with the OCT imaging system.
In this embodiment, circuit board 9 adopts the FPCB flexible circuit board, and the inclined plane of probe base 5 is unanimous basically with flexible circuit board's shape, size, makes things convenient for structure alignment and assembly, and the inclined plane of probe base 5 passes through the point with flexible circuit board and is glued and be connected.
In some specific embodiments, the OCT tomography probe further includes a housing sleeve 2, the reflection prism 3, the probe base 5, the optical fiber concentrator 4, the MEMS micro-galvanometer 7, and the circuit board 9 are all disposed in the housing sleeve 2, and a window lens 1 for transmission and collection of an optical path is disposed at an end face of the housing sleeve 2 close to the MEMS micro-galvanometer 7.
In some embodiments, window lens 1 is coated with an infrared antireflection film for increasing infrared transmittance.
In some embodiments, the housing sleeve 2 is made of medical stainless steel or other materials conforming to medical biocompatibility, and is fixedly connected with the window lens 1 through optical UV glue for isolating interference of an external environment to the inside of the probe, and the inner wall of the housing sleeve 2 can be treated by matting paint or matting cotton to reduce diffuse reflection interference of light beams in the housing sleeve.
The OCT tomography probe is used as a sample arm of an OCT system, and the effects of different OCT imaging distances, different view field sizes and different light spot transverse resolutions can be achieved by jointly designing optical parameters of the window lens 1 and the optical fiber concentrator 4.
In some specific embodiments, the OCT tomographic imaging probe further includes a camera module 6 disposed on the circuit board 9 for assisting the OCT system in adjusting the imaging resolution.
The MEMS micro-vibration mirror 7 is arranged in the center of the circuit board 9, an aluminum film or a gold film is plated on a lens of the MEMS micro-vibration mirror 7 to improve the reflection efficiency of light beams, and the MEMS micro-vibration mirror 7 is supported by the substrate 8 and fixed in the flexible circuit board 9; the camera module 6 is positioned on one side of the MEMS micro-vibrating mirror 7 and used for imaging a tissue sample, the included angle between the imaging surface of the measured tissue and the horizontal plane is 90 degrees, the camera module 6 selects a focusing micro camera module, the imaging distance of the camera module is consistent with the imaging distance of the probe OCT, and the clear imaging surface of the camera is the optimal imaging surface of the OCT.
In some specific embodiments, a first pad and a solder hole 901 for electrically connecting the camera module mirror 6 and a second pad and a solder hole 902 for electrically connecting the MEMS micro-resonator mirror 7 are further disposed on the circuit board 9, the first pad and the solder hole 901 and the second pad and the solder hole 902 are disposed corresponding to the side surface mounting groove 52, and the electric wire 11 is directly electrically connected to the first pad and the solder hole 901 and/or the second pad and the solder hole 902 after being routed along the side surface mounting groove 52. In order to control the imaging module mirror 6 and the MEMS micro-vibrating mirror 7, the total number of the first pads and solder holes 901 and the second pads and solder holes 902 should be not less than 5.
In some embodiments, a leather sheath groove 10 is formed in the probe base 5, and a leather sheath is arranged on the leather sheath groove 10 to fix the optical fiber concentrator 4, the probe base 5 and the electric wire 11 in a combined manner.
The schematic diagram of the optical path of the OCT tomography probe is shown in fig. 6, a light beam 12 emitted by the OCT system is reflected by the fiber concentrator 4 and the reflecting prism 3 and enters the lens of the MEMS micro-vibration mirror 7, the micro-vibration mirror 7 can realize large-angle vibration in the two-dimensional direction, the light beam 12 is driven to deflect, the two-dimensional point scanning imaging of the OCT on the focal plane 101 is finally realized through the secondary amplification of the window lens 1 and the fixed imaging distance, and the focal plane 101 is the surface of cervical tissue. Because the MEMS micro-vibrating mirror 7 as a scanning mechanism is positioned at the front end of the probe, a light path can realize a larger angle, and the OCT imaging view field can be larger than the diameter of the probe, thereby imaging the whole cervical region and avoiding the risks of multiple detection and missed detection.
The light beam 12 includes infrared light output by the OCT light source and visible laser light for guiding the imaging of the camera module 6, and as typical values, broadband infrared light with a center wavelength of 1310nm and visible red light with a wavelength of 633nm are selected, and the infrared light and the visible laser light are simultaneously incident into the optical fiber concentrator 4 through the optical fiber coupler.
An OCT imaging system comprising an OCT tomographic imaging probe as described above.
As shown in fig. 8, a tomography method of the OCT imaging system described above specifically includes the following steps:
s1: the light beam 12 emitted by the OCT system is reflected back by the optical fiber condenser 4 and the reflecting prism 3 and enters the lens of the MEMS micro-vibrating mirror 7.
S2: the micro-galvanometer 7 is controlled to realize the vibration of the angle in the two-dimensional direction, the light beam 12 is driven to deflect, the light beam is transmitted to the tissue to be detected after the secondary amplification of the window lens 1 and the fixed imaging distance, the OCT image of the tissue to be detected is obtained, and the OCT three-dimensional data of the tissue to be detected can be obtained.
The movement track of the MEMS micro-galvanometer 7 is designed and controlled, so that the light beam 12 performs one-time clockwise annular surface scanning, a shadow area in the graph 7 is an OCT (optical coherence tomography) imaging area of the tissue to be detected, an OCT image is synchronously recorded, and then cervical OCT three-dimensional data can be obtained.
S3: and extracting and outputting an accurate position image of a required observation point from the measured tissue OCT three-dimensional data.
The accurate position image of 12 points can be extracted from the three-dimensional data through processing and analysis, namely, only one-time scanning is needed to generate the tomographic image of 12 point positions of the cervix, and due to noninvasive real-time and high resolution of OCT imaging, abnormal tissue structures and shadow areas can be conveniently found, the risks of repeated detection and missed detection can be effectively reduced, and oversampling biopsy of the cervix is also avoided.
Wherein, because the light source of the OCT system is invisible infrared light, it is troublesome to adjust the optical paths of the sample arm and the reference arm, in order to achieve the optical paths of the sample arm and the reference arm of the OCT system being adjusted to be equal, so as to achieve the optimal OCT imaging effect, before S1, the method further includes the following steps:
s01: a light beam 12 which is emitted by the OCT system and contains visible laser enters a lens of the MEMS micro-vibration mirror 7 through the return of the optical fiber condenser 4 and the reflecting prism 3, is deflected by the MEMS micro-vibration mirror 7, is transmitted to a tested tissue after being secondarily amplified by the window lens 1 and a fixed imaging distance, and is preliminarily imaged by the camera module 6.
S02: the distance from the OCT tomography probe to the measured tissue is adjusted, so that the imaging of the camera module 6 is gradually clear, and the coarse adjustment of the position and the imaging focal plane of the OCT tomography probe is realized.
For convenience of confirmation, a converged red light spot can be seen in the lens of the camera module 6, and when the converged red light spot is seen, coarse adjustment of the position of the OCT tomography probe and the imaging focal plane is completed.
Because the imaging distance of the camera module 6 is consistent with that of the OCT tomography probe, the optical paths of the sample arm and the reference arm of the OCT system can be ensured to be equal when the focusing of the camera module 6 is finished, and the OCT image can be prevented from being on a frequency multiplication or difference frequency imaging surface of a signal.
S03: the drive voltage or the drive current of the MEMS micro-vibration mirror 7 is controlled to drive the light beam 12 containing the visible laser to carry out y-axis positive direction point scanning, a vertical line can be seen in the imaging of the camera module 6 at the moment, the vertical line is located in the 12 o' clock direction of the tested tissue, the position of the OCT fault imaging probe is finely adjusted, the vertical line is made to be clear in the imaging of the camera module 6, the imaging position and the resolution of the OCT system are in the best state at the moment, and the accurate alignment of the scanning initial position and the imaging area is realized.
This scheme is focused through the visualization of module 6 of making a video recording, and operating personnel need not to possess OCT imaging system's relevant professional knowledge and can equal realization quick adjustment to the optical path of OCT system sample arm and reference arm to reach the best OCT imaging effect, easy operation is convenient, satisfies the operation requirement.
In the description herein, references to the description of the terms "one embodiment," "certain embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
It is to be understood that the invention is not limited to the examples described above, but that modifications and variations may be effected thereto by those of ordinary skill in the art in light of the foregoing description, and that all such modifications and variations are intended to be within the scope of the invention as defined by the appended claims.
Reference numerals:
a window lens 1; a housing sleeve 2; a reflection prism 3; an optical fiber concentrator 4; a probe base 5; a first fiber card slot 51; side mounting slots 52; a camera module 6; an MEMS micro-galvanometer 7; a substrate 8; a circuit board 9; a second fiber card slot 92; first pads and solder holes 901; second pads and vias 902; a leather sheath groove 10; an electric wire 11; a light beam 12; a focal plane 101.
Claims (10)
1. An OCT tomography probe is characterized by comprising a probe base, an optical fiber concentrator and a circuit board, wherein one end face of the probe base is provided with an inclined plane forming a certain angle with a horizontal plane, and the circuit board is fixed on the inclined plane of the probe base; the side surface of the probe base is provided with a first optical fiber clamping groove which penetrates through the whole probe base along the length direction of the probe base, and the shape of the optical fiber clamping groove is matched with that of the optical fiber concentrator; a second optical fiber clamping groove with the shape matched with that of the optical fiber concentrator is formed in the position, corresponding to the first optical fiber clamping groove, of the circuit board; the optical fiber convergence device is fixedly arranged in the first optical fiber clamping groove and the second optical fiber clamping groove.
2. The OCT tomographic imaging probe of claim 1, wherein a distance between two sides of an opening of the first fiber clamping groove is smaller than a diameter of the fiber concentrator.
3. The OCT tomographic imaging probe of any one of claims 1 or 2, wherein a glue is dispensed at a gap between the first fiber groove and the fiber concentrator.
4. The OCT tomography probe of claim 1, comprising a wire, wherein a side mounting groove is formed in a side of the probe base and extends through the entire probe base along a length direction of the probe base, the wire is mounted in the side mounting groove, and the wire is electrically connected to the circuit board.
5. The OCT tomography probe of claim 1, wherein a reflecting prism for light path folding is disposed at one end of the fiber concentrator near the circuit board, a hollow position for positioning and fixing a substrate is disposed in the middle of the circuit board, the substrate is disposed in the hollow position, and an MEMS micro-galvanometer is disposed on the substrate; the micro-vibration optical fiber spectrometer is characterized by further comprising a shell sleeve, the reflecting prism, the probe base, the optical fiber gathering device, the MEMS micro-vibration mirror and the circuit board are all arranged in the shell sleeve, and a window lens used for transmission and collection of a light path is arranged on one end face, close to the MEMS micro-vibration mirror, of the shell sleeve.
6. The OCT tomography probe of claim 5, further comprising a camera module disposed on the circuit board for assisting the OCT system in adjusting the imaging resolution.
7. The OCT tomography probe of claim 6, wherein the circuit board further comprises a first bonding pad and a bonding hole for electrically connecting the camera module mirror, and a second bonding pad and a bonding hole for electrically connecting the MEMS micro-oscillator mirror, wherein the first bonding pad, the bonding hole, the second bonding pad and the bonding hole are arranged corresponding to the side mounting groove, and the electric wire is directly electrically connected with the first bonding pad, the bonding hole, the second bonding pad and the bonding hole after routing along the side mounting groove.
8. An OCT imaging system comprising the OCT tomographic imaging probe according to any one of claims 1 to 6.
9. A tomographic imaging method of the OCT imaging system of claim 8, comprising the steps of:
s1: the light beam emitted by the OCT system is reflected back by the optical fiber concentrator and the reflecting prism and then enters the lens of the MEMS micro-vibrating mirror;
s2: the micro-galvanometer 7 is controlled to realize the vibration of angles in two-dimensional directions, the light beam direction is driven to deflect, the light beam is transmitted to a tested tissue after the secondary amplification of a window lens and a fixed imaging distance, the linear light beam is subjected to one-time clockwise annular surface scanning, the OCT image of the tested tissue is synchronously recorded, and then the OCT three-dimensional data of the tested tissue can be obtained;
s3: and extracting and outputting an accurate position image of a required observation point from the measured tissue OCT three-dimensional data.
10. The tomographic imaging method of the OCT imaging system of claim 9, further comprising, before S1, the steps of:
s01: light beams emitted by the OCT system and containing visible laser enter a lens of the MEMS micro-vibration mirror through the turning back of the optical fiber collector and the reflecting prism, are deflected by the MEMS micro-vibration mirror, are transmitted to a tested tissue through secondary amplification of the window lens and a fixed imaging distance, and are imaged by the camera module;
s02: adjusting the distance from the OCT tomography probe to the measured tissue to enable the imaging of the camera module to be gradually clear, and realizing the coarse adjustment of the position and the imaging focal plane of the OCT tomography probe;
s03: the driving voltage or the driving current of the MEMS micro-vibrating mirror is controlled to drive the light beam containing the visible laser to perform linear scanning, a straight line can be seen in the imaging of the camera module at the moment, the position of the OCT tomography probe is finely adjusted, the straight line is clear in the imaging of the camera module, the imaging position and the resolution of the OCT system are in the best state at the moment, and the accurate alignment of the scanning starting position and the imaging area is realized.
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| CN202010995114.XA CN111956192A (en) | 2020-09-21 | 2020-09-21 | OCT (optical coherence tomography) tomography probe, OCT imaging system and imaging method |
| PCT/CN2021/109006 WO2022057455A1 (en) | 2020-09-21 | 2021-07-28 | Oct tomography probe, oct imaging system and imaging method |
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| WO2022057455A1 (en) * | 2020-09-21 | 2022-03-24 | 佛山光微科技有限公司 | Oct tomography probe, oct imaging system and imaging method |
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