CN111939454A - Skin stimulator for inducing drug absorption - Google Patents

Skin stimulator for inducing drug absorption Download PDF

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Publication number
CN111939454A
CN111939454A CN201910410154.0A CN201910410154A CN111939454A CN 111939454 A CN111939454 A CN 111939454A CN 201910410154 A CN201910410154 A CN 201910410154A CN 111939454 A CN111939454 A CN 111939454A
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CN
China
Prior art keywords
storage tank
skin
liquid medicine
fine needle
infusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910410154.0A
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Chinese (zh)
Inventor
禹龙云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhu I Li Mei Ye Co Ltd
Original Assignee
Zhu I Li Mei Ye Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhu I Li Mei Ye Co Ltd filed Critical Zhu I Li Mei Ye Co Ltd
Priority to CN201910410154.0A priority Critical patent/CN111939454A/en
Publication of CN111939454A publication Critical patent/CN111939454A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles

Abstract

The invention relates to a skin stimulator, in particular to a skin stimulator for inducing drug absorption, which is provided with a drug storage tank for storing drug liquid such as filler, botulinum toxin, vitamins, functional cosmetics and the like, and the upper side of the drug storage tank is sealed by a plug, a plurality of infusion channels and infusion tubes are connected to the lower side of the drug storage tank to supply the drug liquid in the drug storage tank to the epidermis layer of the skin, a valve body capable of opening and closing the infusion channels is arranged at the inlet of the infusion channels to control the drug liquid in the drug storage tank flowing from the infusion channels, then the valve body is opened and closed by the opening and closing means of the valve body, a plurality of fine needles fixed on a fine needle combination body are assembled at the lower side of the drug storage tank, the drug liquid in the drug storage tank can well permeate to the epidermis layer of the skin to cause a wound on the epidermis layer, and the lifting means of the fine needles, the fine needles of the fine needle assembly are lifted and lowered to form a wound in the epidermis.

Description

Skin stimulator for inducing drug absorption
Technical Field
The invention relates to a skin stimulator, which is characterized in that a liquid medicine storage tank for storing liquid medicine such as filler, botulinum toxin, vitamin, functional cosmetics and the like is arranged, a plug is used for blocking the liquid medicine storage tank at the upper side part, a plurality of infusion channels and infusion tubes are connected at the lower side part of the liquid medicine storage tank to supply the liquid medicine in the liquid medicine storage tank to the epidermis layer of the skin, a valve body capable of opening and closing the infusion channels is arranged at the inlet of the infusion channels to control the liquid medicine in the liquid medicine storage tank flowing from the infusion channels, then the valve body is opened and closed by the opening and closing means of the valve body, a plurality of fine needles fixed on a fine needle combination body are assembled at the lower side part of the liquid medicine storage tank, the liquid medicine in the liquid medicine storage tank can well permeate into the epidermis layer of the skin to cause a wound on the epidermis layer, the fine needles on the epidermis layer are lifted and simultaneously cause the wound on, because the valve body in the liquid medicine storage tank can block the liquid medicine conveying channel under normal conditions, the liquid medicine in the liquid medicine storage tank can be kept in a storage state, and the liquid medicine conveying channel is opened at the moment when the contact surface of the lifting rod contacts the epidermis layer of the skin, so that the liquid medicine is supplied to the epidermis layer, and the quick and smooth liquid medicine supply effect is obtained; and at the moment when the liquid medicine in the liquid medicine storage tank is supplied to the skin, current is supplied to the coil of the bobbin according to the instruction of the circuit board to promote the magnet to move up and down, so that the fine needle combination body combined with the magnet also moves up and down along with the magnet, a plurality of fine needles combined on the fine needle combination body puncture the skin epidermis layer to cause a wound, and the liquid medicine supplied to the epidermis layer is quickly absorbed by the epidermis layer, thereby achieving the improved liquid medicine administration effect. The prepared skin stimulator has a diameter of less than about 50mm, can be held by one hand, and can easily puncture sebum, so that the skin stimulator has good conditions for inducing the liquid medicine to be absorbed by the epidermis layers of the face, the arms, the legs and the like, and is a skin stimulator which is convenient to use and carry, can promote the liquid medicine to be absorbed by the epidermis layers of the skin at any time and any place and is used for inducing the absorption of the medicine.
Background
An apparatus for administering and absorbing a drug solution such as a filler, a botulinum toxin, a vitamin, a functional cosmetic, etc. to the skin was first patented, and a "fine needle treatment device" is disclosed in laid-open patent No. 10-2015-0033134.
The structure of the above conventional art includes: a main body part with an open-state receiving hole formed at one end; a power unit for providing a reciprocating force along a longitudinal direction of the receiving hole installed in the main body; and a fine needle module part, one end of which is provided with a fine needle, the other end of which is contained in the containing hole in a state of being combined with the power part, and the fine needle can extend out of the containing hole by the aid of the reciprocating force of the power part.
The invention using the conventional technology is that the fine needle module part accommodated in the accommodating hole of the main body part is driven by the reciprocating force of the power part, so that the fine needle treatment device can be used more easily and stably, and the structure is simple.
However, the above conventional techniques have only an effect of stimulating the skin, and are not used together with the drug, thus being different from the present invention.
Further, since the power source of the above conventional art is driven by a motor, it is different from the driving manner of the present invention by a coil and a magnet.
Disclosure of Invention
[ problem to be solved ]
The present invention is intended to solve and improve the above-mentioned problems, etc., and has an object to:
generally, a valve body in the liquid medicine storage tank blocks the infusion channel, so that the liquid medicine in the liquid medicine storage tank can be kept in a storage state, the infusion channel is opened at the moment that the contact surface of the lifting rod contacts the epidermis layer of the skin, so that the liquid medicine is supplied to the epidermis layer, and a quick and smooth liquid medicine supply effect is obtained. The prepared skin stimulator has a diameter of less than about 50mm, can be held by one hand, and can easily puncture sebum, so that the skin stimulator has good conditions for inducing the absorption of the liquid medicine by the epidermis of face, arms, legs, etc., and is a skin stimulator for inducing the absorption of the liquid medicine by the epidermis of skin, which is convenient to use and carry, and can be used anytime and anywhere.
[ MEANS FOR solving PROBLEMS ] to solve the problems
In order to achieve the above object, the present invention provides a liquid medicine storage tank for storing liquid medicine such as a filler, botulinum toxin, vitamins, functional cosmetics, etc., the liquid medicine storage tank being closed by a stopper, a plurality of infusion paths and infusion tubes being connected to a lower side portion of the liquid medicine storage tank to supply the liquid medicine of the liquid medicine storage tank to the epidermis layer of the skin, a valve body being provided at an inlet of the infusion path to open and close the infusion paths to control the liquid medicine of the liquid medicine storage tank flowing from the infusion paths, the valve body being opened and closed by opening and closing means of the valve body, a plurality of fine needles being fixed to a fine needle assembly being assembled to a lower side portion of the liquid medicine storage tank to allow the liquid medicine of the liquid medicine storage tank to well penetrate into the epidermis layer of the skin to cause a wound on the epidermis layer, the fine needles of the fine needle assembly being lifted and lowered on the epidermis layer while being lifted and lowered, thereby achieving the object of the present invention.
[ Effect of the invention ]
In the present invention, since the valve body in the drug solution storage tank is normally closed to the infusion path, the drug solution in the drug solution storage tank is kept stored, and the infusion path is opened at the moment when the contact surface of the elevating rod contacts the epidermis layer of the skin, so that the drug solution is supplied to the epidermis layer, thereby achieving a rapid and smooth drug solution supply effect.
In the present invention, at the moment when the liquid medicine in the liquid medicine storage tank is supplied to the skin, the current is supplied to the coil of the bobbin according to the instruction of the circuit board to move the magnet up and down, so that the fine needle combination body combined with the magnet also moves up and down together with the magnet, the plurality of fine needles combined with the fine needle combination body pierce the epidermis layer of the skin to cause a wound, and the liquid medicine previously supplied to the epidermis layer is rapidly absorbed by the epidermis layer, thereby achieving an improved liquid medicine administration effect.
The present invention as described above has excellent effects, and the prepared skin stimulator has a diameter of less than about 50mm, can be held with one hand, and easily punctures sebum, so that it has excellent conditions for inducing the absorption of the drug solution into the epidermis of the face, arms, legs, etc., and is convenient to use and carry, and can be used at any time and any place to promote the absorption of the drug solution into the epidermis of the skin.
Drawings
FIG. 1 is an exploded view for explaining the structure of a skin stimulator according to the present invention;
FIG. 2 is a schematic view for explaining the structural constitution of the skin stimulator according to the present invention;
FIG. 3 is a schematic view for explaining the drug supplying action of the skin stimulator according to the present invention;
FIG. 4 is a schematic view for explaining the lifting and lowering action of the fine needle of the skin stimulator according to the present invention;
in the figure, the position of the upper end of the main shaft,
101-upper case 102-upper combining hole
103-lower case 104-lower coupling hole
111-chemical liquid storage tank 112-storage tank
113-bracket 114-connecting hole
115-infusion tube 116-infusion channel
121-valve body 122-insertion hole
131-bobbin 132-coil
133-insertion space portion 134-magnet
141-lifting rod 142-contact piece
143-elastic member 151-fine needle combination
152-guide hole 153-through hole
154-fine needle 161-contact body
162-contact surface 163-underside guide hole
164-support hole 165-fine needle guide hole
171-plug 172-infusion orifice
181-battery 182-circuit board
191-epidermis 192-dermis
193-fatty layer.
Detailed Description
The structural components of the present invention are explained in detail with reference to the accompanying drawings.
This structure is provided with:
the medical liquid storage tank 111 on the upper side is sealed by a plug 171 for storing medical liquids such as filler, botulinum toxin, vitamins, functional cosmetics, etc.;
a plurality of infusion channels 116 and an infusion tube 115 are connected to the lower side of the drug solution storage tank 111 to supply the drug solution in the drug solution storage tank 111 to the skin epidermis 191;
a valve body 121 disposed at the inlet of the infusion channel 116 for opening and closing the infusion channel 116 to control the liquid medicine flowing from the infusion channel 116 into the liquid medicine storage tank 111;
a valve body opening and closing means for opening and closing the liquid delivery passage 116 by the valve body 121;
a plurality of fine needles 154 assembled to the lower side portion and fixed to the fine needle combination body 151 to cause a wound on the epidermis layer 191 and promote the medical fluid in the medical fluid storage tank 111 to well penetrate into the epidermis layer 191 of the skin;
the fine needle raising and lowering function is to cause a wound in the epidermis layer while raising and lowering the fine needles 154 of the fine needle combination body 151.
A lifting rod 141 which is pressed into the insertion hole 122 of the valve body 121 through the connection hole 114 of the chemical solution storage tank 111 and the guide hole 152 of the fine needle combination body 151 and is integrated with the valve body 121;
a contact piece 142 formed on the lower side of the lifting rod 141 and contacting the skin;
a resilient member 143 which is resiliently provided between the contact piece 142 of the elevating bar 141 and the connection hole 114 of the chemical solution storage tank 111, and which is configured to cause a compression action when the contact piece 142 is raised to bring the contact piece 142 back to its original position by a relaxation force when the contact is not made.
Further, the fine needle lifting means includes: a magnet 134 forming an outer peripheral surface of a fine needle combination body 151 formed by combining the fine needles 154;
a coil 132 wound layer upon layer on a bobbin 131 forming an outer circumferential surface of the chemical solution storage tank 111 is combined to generate a magnetic force from a magnet 134 so that the magnet 134 can be moved up and down by the magnetic force when the polarity is switched;
the upper and lower housings 101, 103 house both a battery 181 and a circuit board 182 for generating an electric current from the coil 132 so that the coil 132 can be switched to a cathode and an anode.
A contact surface 162 which is coupled to the lower side of the chemical solution storage tank 111 and has a bottom portion contacting the skin in order to guide the chemical solution supplied from the chemical solution storage tank 111 to well penetrate into the epidermal layer 191 of the wound generated by the raising and lowering of the fine needle 154; a support hole 164 for supporting the infusion tube 115 of the drug solution storage tank 111; a lower guide hole 163 at the center through which the contact piece 142 of the lifting rod 141 can be inserted and withdrawn; and a contact body 161 formed by a plurality of fine needle guide holes 165 through which the fine needles 154 of the fine needle combination body 151 can be inserted and withdrawn.
The operation of the present invention described above will be explained below.
Fig. 1 is an exploded schematic view for explaining a structure of a skin stimulator according to the present invention. Fig. 2 is a schematic diagram for explaining the structural composition of the skin stimulator according to the present invention, and in order to store a chemical such as a filler, botulinum toxin, vitamin, and functional cosmetics in the chemical storage tank 111 coupled to the upper and lower housings 101 and 103, the chemical is injected through the infusion hole 172 formed in the stopper 171 for closing the upper side portion of the chemical storage tank 111.
When the upper and lower housings 101 and 103 are held with one hand, the infusion hole 172 formed in the plug 171 is closed by the finger pad of the index finger, thereby preventing the outflow of the drug solution through the infusion hole 172.
As described above, when the skin stimulator according to the present invention is held, the contact surface 162 of the contact body 161 exposed from the lower coupling hole 104 of the lower housing 103 is brought into contact with the liquid medicine input portion such as the face, the arms, or the legs.
As described above, at the moment when the contact surface 162 of the contact body 161 contacts the skin, the contact piece 142 protruding from the lower guide hole 163 of the contact body 161 contacts the skin first, and the elastic member 143 provided between the contact piece 142 and the connection hole 114 of the chemical solution storage tank 111 is compressed by the pressure, and the lifting rod 141 integrated with the contact piece 142 is pushed and moved upward.
When the valve body 121, which is integrated with the elevating rod 141 by the upward movement of the elevating rod 141, moves upward from the support 113 of the chemical solution storage tank 111, the infusion path 116 of the chemical solution storage tank 111, which is closed, is opened.
Therefore, the medical fluid stored in the medical fluid storage tank 111 is injected through the plurality of infusion paths 116 formed at the bottom of the medical fluid storage tank 111, and is supplied to the skin through the plurality of infusion tubes 115 connected to the respective infusion paths 116 and the plurality of support holes 164 formed in the contact body 161, as shown in fig. 3, while being in surface contact with the epidermis 191.
As described above, when the contact surface 162 of the contact body 161 contacts the skin layer 191, the contact piece 142 is raised, the chemical liquid in the chemical liquid storage tank 111 is supplied to the skin layer 191, and the user presses the start key (not shown) attached to the upper housing 101.
When the circuit board 182 mounted in the upper housing 101 receives a current from the battery 181 by the pressing operation of the start key, the polarity switching current of the coil 132 of the bobbin 131 forming the insertion space 133 is turned on the outer peripheral surfaces of the chemical solution storage tank 111 and the contact body 161, and the magnet 134 mounted inside the contact body 161 and coupled to the outer peripheral surface of the fine needle combination 151 is moved up and down.
Then, the fixed fine needle combination 151 is also lifted by the magnet 134, and the plurality of fine needles 154 joined to the fine needle combination 151 are guided by the plurality of fine needle guide holes 165 formed in the contact body 161 to lift as shown in fig. 4, thereby causing a wound in the skin epidermis 191.
As described above, the medical fluid previously supplied to the epidermal layer 191 can smoothly permeate through the wound caused by the plurality of fine needles 154.
In addition, the fine needle 154 does not penetrate the dermal layer 192 and the fat layer 193 of the skin, but penetrates only to a predetermined depth of the epidermal layer 191, causing a fine wound, so that the medical fluid is supplied only to the epidermal layer 191, and blood can be prevented from flowing out of the surface of the epidermal layer.
Further, since the skin layer 191 of the skin is filled with the chemical solution, the upper and lower housings 101 and 103 are isolated from the skin, the contact piece 142 compressed into the guide hole 163 on the lower side of the contact body 161 is lowered back to its original position together with the elevating rod 141 by the relaxation force of the elastic member 143, and the valve body 121 integrated with the upper side portion of the elevating rod 141 is naturally lowered at the same time, so that the respective transfusion passages 116 of the chemical solution storage tank 111 are closed, and the chemical solution in the chemical solution storage tank 111 is not supplied any more, and the next stage is waited.
Further, when the pressed start key is released at the moment when the upper and lower housings 101 and 103 are separated from the skin, the power of the battery 181 cannot be supplied to the circuit board 182, and therefore the lifting operation of the magnet 134 and the fine needle combination 151 is naturally stopped to wait for the next instruction.

Claims (4)

1. A skin stimulator for inducing drug absorption, comprising:
a liquid medicine storage tank (111) sealed at the upper side part by a plug (171) for storing at least one liquid medicine including a filler, a botulinum toxin, vitamins and a functional cosmetic;
a plurality of infusion channels (116) and infusion tubes (115) are connected to the lower side part of the liquid medicine storage tank (111) so as to supply the liquid medicine in the liquid medicine storage tank (111) to a skin epidermis layer (191);
a valve body (121) which is arranged at the inlet of the transfusion channel (116) and opens and closes the transfusion channel (116) so as to control the liquid medicine flowing into the liquid medicine storage tank (111) from the transfusion channel (116);
a valve body opening and closing means for opening and closing the infusion passage (116) by the valve body (121);
a plurality of fine needles 154 assembled to the lower side portion and fixed to the fine needle combination body 151 to cause a wound on the epidermis layer 191 and promote the medical fluid in the medical fluid storage tank 111 to well penetrate the epidermis layer 191 of the skin;
and a function of lifting the fine needle such that the fine needle (154) of the fine needle combination body (151) is lifted up and down to cause a wound in the epidermis layer.
2. The skin stimulator for inducing absorption of a drug according to claim 1, further comprising:
a lifting rod (141) which is pressed into the insertion hole (122) of the valve body (121) through the connection hole (114) of the chemical liquid storage tank (111) and the guide hole (152) of the fine needle combination body (151) and is integrated with the valve body (121);
a contact piece (142) formed on the lower side of the lifting rod (141) and contacted with the skin;
and a resilient elastic member (143) which is provided between the contact piece (142) of the lifting rod (141) and the connection hole (114) of the chemical solution storage tank (111) and which can be bounced, wherein the contact piece (142) is caused to return to its original position by a relaxation force when the contact piece (142) is not in contact with the skin and a compression action is generated when the contact piece (142) is lifted.
3. The skin stimulator for inducing absorption of a drug according to claim 1, wherein:
the fine needle lifting means comprises a magnet (134) forming the outer peripheral surface of a fine needle combination body (151) formed by combining the fine needles (154);
a coil (132) wound layer upon layer on a bobbin (131) forming the outer peripheral surface of the chemical solution storage tank (111) is combined to make the magnet (134) generate magnetic force, so that the magnet (134) can be lifted up and down by the magnetic force when the polarity is switched;
a battery (181) and a circuit board (182) are mounted in the upper and lower housings (101), (103) simultaneously, so that the coil (132) generates electric current, so that the coil (132) can be switched into a cathode and an anode.
4. The skin stimulator for inducing absorption of a drug according to claim 1, further comprising:
a contact surface (162) which is combined with the lower side part of the liquid medicine storage tank (111) and the bottom part of which is contacted with the skin in order to guide the liquid medicine supplied by the liquid medicine storage tank (111) to well permeate into the epidermal layer (191) of the wound generated under the lifting action of the fine needle (154); a support hole (164) for supporting the infusion tube (115) of the drug solution storage tank (111); a lower guide hole (163) which is located at the center and through which the contact piece (142) of the lifting rod (141) can be inserted and withdrawn; and a contact body (161) formed by a plurality of fine needle guide holes (165) through which the fine needles (154) of the fine needle combination body (151) can be inserted and withdrawn.
CN201910410154.0A 2019-05-16 2019-05-16 Skin stimulator for inducing drug absorption Pending CN111939454A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910410154.0A CN111939454A (en) 2019-05-16 2019-05-16 Skin stimulator for inducing drug absorption

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910410154.0A CN111939454A (en) 2019-05-16 2019-05-16 Skin stimulator for inducing drug absorption

Publications (1)

Publication Number Publication Date
CN111939454A true CN111939454A (en) 2020-11-17

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Country Status (1)

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CN (1) CN111939454A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114376569A (en) * 2022-01-19 2022-04-22 浙江大学 Glucagon-carrying wearable device for treating hypoglycemia

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050000514A1 (en) * 2001-01-12 2005-01-06 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US20050251095A1 (en) * 2004-05-07 2005-11-10 Giap Brandon C Improved medication injection device
US20090042970A1 (en) * 2007-08-06 2009-02-12 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
CN101616709A (en) * 2007-02-22 2009-12-30 厄弗翁简易股份公司 The miniaturized injection device that is used for medical application
US20120046644A1 (en) * 2010-08-20 2012-02-23 Purdue Research Foundation Touch-actuated micropump for transdermal drug delivery and method of use
CN102413853A (en) * 2009-04-09 2012-04-11 韩国生命工学研究院 Microneedle unit capable of controlling fluid delivery
US20120310155A1 (en) * 2011-05-31 2012-12-06 Jeremy Heiser Apparatus and method for dermal delivery
CN102844072A (en) * 2010-01-29 2012-12-26 优比欧迈德有限公司 Micro needle and micro needle device
US20150073385A1 (en) * 2013-09-10 2015-03-12 California Institute Of Technology Remote reservoir microneedle drug delivery systems
KR20150033134A (en) * 2013-09-23 2015-04-01 (주)센트로닉스 Microneedle therapy apparatus
US20150133866A1 (en) * 2012-07-25 2015-05-14 Toppan Printing Co., Ltd. Operation tool for fluid injector using multi-microneedle device
WO2016195200A1 (en) * 2015-05-30 2016-12-08 주식회사 하일 Fluid injection apparatus for skin stimulation
CN106232170A (en) * 2014-02-17 2016-12-14 杰夫·贝克 The system and method detected and prevent wet type from injecting
KR101711350B1 (en) * 2016-07-25 2017-03-02 김미영 Skin hand-operated injector
KR20180066512A (en) * 2016-12-09 2018-06-19 권영일 Apparatus for skin care
CN207804783U (en) * 2017-06-07 2018-09-04 广州集思容器制品有限公司 A kind of beauty fine needle
WO2018190681A1 (en) * 2017-04-13 2018-10-18 쎌베이 주식회사 Medication injection-type microneedle device
US20190134371A1 (en) * 2016-04-15 2019-05-09 Ink Machines Sweden Ab Disposable tattoo needle cartridge

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050000514A1 (en) * 2001-01-12 2005-01-06 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US20050251095A1 (en) * 2004-05-07 2005-11-10 Giap Brandon C Improved medication injection device
CN101616709A (en) * 2007-02-22 2009-12-30 厄弗翁简易股份公司 The miniaturized injection device that is used for medical application
US20090042970A1 (en) * 2007-08-06 2009-02-12 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
CN102413853A (en) * 2009-04-09 2012-04-11 韩国生命工学研究院 Microneedle unit capable of controlling fluid delivery
CN102844072A (en) * 2010-01-29 2012-12-26 优比欧迈德有限公司 Micro needle and micro needle device
US20120046644A1 (en) * 2010-08-20 2012-02-23 Purdue Research Foundation Touch-actuated micropump for transdermal drug delivery and method of use
US20120310155A1 (en) * 2011-05-31 2012-12-06 Jeremy Heiser Apparatus and method for dermal delivery
US20150133866A1 (en) * 2012-07-25 2015-05-14 Toppan Printing Co., Ltd. Operation tool for fluid injector using multi-microneedle device
US20150073385A1 (en) * 2013-09-10 2015-03-12 California Institute Of Technology Remote reservoir microneedle drug delivery systems
KR20150033134A (en) * 2013-09-23 2015-04-01 (주)센트로닉스 Microneedle therapy apparatus
CN106232170A (en) * 2014-02-17 2016-12-14 杰夫·贝克 The system and method detected and prevent wet type from injecting
WO2016195200A1 (en) * 2015-05-30 2016-12-08 주식회사 하일 Fluid injection apparatus for skin stimulation
US20190134371A1 (en) * 2016-04-15 2019-05-09 Ink Machines Sweden Ab Disposable tattoo needle cartridge
KR101711350B1 (en) * 2016-07-25 2017-03-02 김미영 Skin hand-operated injector
KR20180066512A (en) * 2016-12-09 2018-06-19 권영일 Apparatus for skin care
WO2018190681A1 (en) * 2017-04-13 2018-10-18 쎌베이 주식회사 Medication injection-type microneedle device
CN207804783U (en) * 2017-06-07 2018-09-04 广州集思容器制品有限公司 A kind of beauty fine needle

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114376569A (en) * 2022-01-19 2022-04-22 浙江大学 Glucagon-carrying wearable device for treating hypoglycemia
CN114376569B (en) * 2022-01-19 2023-10-13 浙江大学 Glucagon-carrying wearable device for treating hypoglycemia

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