CN111939216A - Medicinal moxibustion with rapid onset and analgesic effect and preparation method thereof - Google Patents
Medicinal moxibustion with rapid onset and analgesic effect and preparation method thereof Download PDFInfo
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- CN111939216A CN111939216A CN202010826833.9A CN202010826833A CN111939216A CN 111939216 A CN111939216 A CN 111939216A CN 202010826833 A CN202010826833 A CN 202010826833A CN 111939216 A CN111939216 A CN 111939216A
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- moxibustion
- essential oil
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Abstract
The invention relates to the technical field of health products, and discloses a medicinal moxibustion with quick response and analgesic function, which comprises a heating bag and a plaster; the heating bag comprises a heating agent and a material bag, and the plaster comprises liposome and a medicine bag; the liposome comprises, by weight, 10-25 parts of lecithin, 18-24 parts of compound essential oil and 50-62 parts of a traditional Chinese medicine carrier; the traditional Chinese medicine carrier comprises, by weight, 40-90 parts of folium artemisiae argyi, 15-25 parts of asarum, 5-8 parts of rhizoma gastrodiae, 15-25 parts of radix angelicae, 4-8 parts of safflower, 1-8 parts of rhizoma atractylodis, 4-8 parts of mangnolia officinalis, 3-6 parts of agilawood, 2-5 parts of radix dipsaci, 4-8 parts of radix aconiti, 3-6 parts of rhizoma typhonii and 8-16 parts of rheum officinale; the invention also discloses a preparation method of the medicinal moxibustion; the medicinal moxibustion achieves the effect of analgesia under the conditions of quick response, effective temperature control and green safety.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to a medicinal moxibustion with quick response and analgesic function and a preparation method thereof.
Background
Under the new background of the national rapid development of economic science and technology and the new background of the educational field, the living standard of people is gradually improved, the cognitive level and the cultural literacy are also greatly improved, more and more people begin to know and recognize the fields of traditional Chinese medicine and Chinese medicine, and have new knowledge about the fields. Correspondingly, a plurality of traditional Chinese medicine specialties are added in each medical institution, so that convenience is provided for the development of traditional Chinese medicine and traditional Chinese medicine, and talents are also cultivated; meanwhile, a plurality of normative traditional Chinese medicine hospitals are established in society, so that people can seek help and treat diseases conveniently. Therefore, the field of traditional Chinese medicine is rapidly developed.
Moxibustion, which is an extension of ancient moxibustion therapy, is one of the oldest medical techniques in China, belongs to physical therapy of external treatment, and is originated in ancient times, formed in business weeks for thousands of years. Traditionally, the main component of medicinal moxibustion is only folium artemisiae argyi, which has the effects of resisting inflammation, dispelling wind and removing dampness, and can rapidly dredge channels and collaterals of a human body, expel wind-cold-dampness evil in the human body out of the body and achieve the aim of rapidly curing chronic diseases. In the existing medicinal moxibustion, more different Chinese herbal medicine components are added into folium artemisiae argyi so as to perform targeted treatment on different focus.
The analgesic moxibustion is generally a medicinal moxibustion for treating pain. The traditional Chinese medicine considers that the factors causing pain are very many, such as congestion, meridian obstruction, viscera weakness, disharmony of qi and blood and the like, the common part of the factors is that the congestion causes the feeling of body pain, and the analgesic moxibustion can just dredge the congestion by the contained traditional Chinese medicine components.
However, the analgesic moxibustion in the prior art has the following disadvantages:
1. the pertinence is not strong;
2. the effect taking speed is slow, and the curative effect is unsatisfactory;
3. the use temperature of the medicinal moxibustion is difficult to control, and rapid and large-scale temperature rise can bring discomfort to patients and even cause scald;
4. asarum is used as the main component of analgesic moxibustion, contains substances with renal toxicity, and causes risks to the health of patients;
5. generates a large amount of smoke and can cause smoke poisoning after long-term use.
Chinese patent document CN201210146338.9, application date 20120511, entitled: a Chinese herbal medicine analgesic moxibustion is disclosed, which is prepared from the following raw materials in parts by weight: 20-30 parts of carbon, 50-60 parts of wormwood, 8-10 parts of astragalus membranaceus, 15-20 parts of codonopsis pilosula, 8-12 parts of monkshood, 8-12 parts of divaricate saposhnikovia root, 8-12 parts of angelica sinensis, 4-6 parts of safflower carthamus, 8-15 parts of radix angelicae pubescentis, 8-12 parts of caulis sinomenii, 8-12 parts of kadsura pepper stem, 8-10 parts of Chinese pine bark, 4-6 parts of agilawood, 8-10 parts of elecampane, 2-5 parts of borneol, 4-6 parts of ligusticum wallichii, 12-18 parts of sandalwood, 8-10 parts of notopterygium root, 8.
The patent documents achieve the effects of promoting blood circulation, removing blood stasis, expelling wind, removing cold, supporting yang, consolidating the constitution, regulating qi and blood and the like through the compatibility of all components, can relieve pain, reduce swelling, enhance muscle tension, recover muscle function, promote blood circulation and nerve conduction through dredging channels and collaterals, and has good treatment effect, no smoke toxicity and no toxic or side effect. However, the technical scheme of moxibustion which can realize analgesic function under the conditions of quick effect, effective temperature control and green safety is not mentioned yet.
Therefore, there is a need for a drug moxibustion that can achieve analgesia with fast onset, effective temperature control, and green safety.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a medicinal moxibustion with quick response and an analgesic function and a preparation method thereof so as to achieve the analgesic effect under the conditions of quick response, effective temperature control and green safety.
The purpose of the invention is realized by the following technical scheme: a medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch; the heating bag comprises a heating agent and a material bag, and the plaster comprises liposome and a medicine bag;
the liposome comprises, by weight, 10-25 parts of lecithin, 18-24 parts of compound essential oil and 50-62 parts of a traditional Chinese medicine carrier;
the traditional Chinese medicine carrier comprises, by weight, 40-90 parts of folium artemisiae argyi, 15-25 parts of asarum, 5-8 parts of rhizoma gastrodiae, 15-25 parts of radix angelicae, 4-8 parts of safflower, 1-8 parts of rhizoma atractylodis, 4-8 parts of mangnolia officinalis, 3-6 parts of agilawood, 2-5 parts of radix dipsaci, 4-8 parts of radix aconiti, 3-6 parts of rhizoma typhonii and 8-16 parts of rheum officinale.
Further, the compound essential oil comprises, by weight, 1-3 parts of tea tree essential oil, 1-3 parts of cinnamon essential oil and 1-3 parts of myrrh essential oil.
Further, the preparation method of the liposome comprises the following steps:
s1, weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
s2, crushing and screening the traditional Chinese medicine carrier to obtain crushed materials of 800-1000 meshes for later use;
s3, mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution for later use;
s4, dissolving the lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
s5, mixing the crushed material and the mixed solution with a lipid film, and carrying out ultrasonic oscillation treatment to obtain a liposome suspension;
s6, freeze-drying the liposome suspension to obtain the liposome.
Further, in S3, the concentration of the compound essential oil in the mixed solution is 16-25 g/L.
Further, in S5, the ultrasonic oscillation treatment time is 15-30 min; the frequency of the ultrasonic wave is 350-380 MHz, and the frequency of the oscillation is 210-220 rpm.
Further, the heat generating agent comprises, by weight, 40-80 parts of iron powder, 10-30 parts of a water gel, 4-10 parts of diatomite, 10-20 parts of a catalyst and 5-10 parts of a coupling agent.
Further, the water-gel comprises 1-2 parts by weight of super absorbent resin, 2-4 parts by weight of salt and 10-20 parts by weight of water;
the coupling agent comprises, by weight, 1-2 parts of polyethylene glycol, 8-15 parts of vaseline, 8-10 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 8-12 parts of lanolin.
Further, the preparation method of the heating agent comprises the steps of weighing the iron powder, the water gel, the diatomite, the catalyst and the coupling agent according to the proportion, and uniformly mixing the materials to obtain the heating agent.
Furthermore, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer; the first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged on the first breathable film layer and the second breathable film layer.
A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
s7, putting the liposome into a medicine bag to obtain the ointment paste;
s8, putting the heating agent into a material bag to obtain the heating bag;
s9, mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
The medicinal properties of the raw materials adopted by the invention are as follows:
folium artemisiae argyi: pungent and bitter in flavor, warm in nature, entering liver, spleen and kidney meridians. Has the functions of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness and relieving itching. It can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, gestational hemorrhage, menoxenia, dysmenorrhea, threatened abortion, psychroalgia of heart and abdomen, diarrhea, dysentery, cholera, spasm of muscle, leukorrhagia, eczema, scabies, tinea, hemorrhoid, and carbuncle.
Asarum: pungent in flavor and warm in nature, it enters lung, kidney and heart meridians. Has the functions of relieving exterior syndrome, dispelling cold, expelling wind, relieving pain, dredging orifices, warming lung and eliminating phlegm. Can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold.
Rhizoma gastrodiae: pungent in flavor and warm in nature, enter lung meridian. Has the functions of dispersing lung qi, regulating qi, relieving cough and removing blood stasis. It is used for treating common cold, lung carbuncle, and hemoptysis.
Radix angelicae: pungent in flavor and warm in nature, it enters lung, spleen and stomach meridians. Has effects in relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind, and relieving itching. It can be used for treating wind-cold type common cold, headache, toothache, arthralgia, nasosinusitis, leukorrhagia, skin sore, carbuncle, skin pruritus due to wind-dampness, etc.
Safflower: pungent flavor and warm property, enter heart and liver meridians. Has the functions of promoting blood circulation to restore menstrual flow, removing blood stasis and relieving pain. Can be used for treating amenorrhea due to blood stagnation, dysmenorrhea, puerperal abdominal pain due to blood stasis, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, hypochondriac pain, traumatic injury, swelling and pain due to blood stasis, and macula due to blood stasis.
Rhizoma atractylodis: pungent and bitter in flavor, warm in nature, entering spleen, stomach and liver meridians. Has the functions of eliminating dampness, strengthening spleen, dispelling wind and cold and improving eyesight. Can be used for treating damp retention in middle warmer, abdominal distention, diarrhea, edema, tinea pedis, cramped atrophy, rheumatalgia, wind cold type common cold, nyctalopia, dim eyesight, and astringency.
Magnolia officinalis: bitter and pungent in flavor, warm in nature, entering spleen, stomach, lung and large intestine meridians. Has the effects of eliminating dampness and phlegm, descending qi and relieving fullness. It can be used for treating damp retention in middle warmer, abdominal distention, dyspepsia, abdominal distention, constipation, lung qi stagnation, phlegm retention, asthma, cough, cholera, diarrhea, depression, and globus hystericus due to stagnation of phlegm and qi.
Agilawood: pungent and bitter in flavor, slightly warm in nature, entering spleen, stomach and kidney meridians. Has the effects of promoting qi circulation, relieving pain, warming middle energizer, relieving vomit, and relieving asthma. It can be used for treating chest and abdomen distention and pain due to cold accumulation and qi stagnation, stomach cold emesis, and asthma due to kidney deficiency.
And (3) Himalayan teasel root: bitter, sweet and pungent in flavor, slightly warm in nature, entering liver and kidney meridians. Has the functions of tonifying liver and kidney, reuniting tendons and bones, and promoting blood circulation. Can be used for treating deficiency of liver and kidney, soreness of waist and knees, arthralgia due to cold-dampness, metrorrhagia, metrostaxis, threatened abortion, traumatic injury, and fracture of tendons and bones.
Radix aconiti: pungent, bitter and hot in flavor; it enters heart, liver, spleen and kidney meridians. Has the functions of expelling wind and removing dampness, warming channel, dispelling cold and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, numbness of limbs, hemiplegia, headache due to wind-cold evil, psychroalgia of heart and abdomen, cold hernia pain, traumatic injury, blood stasis and pain, cellulitis, toxic swelling, anesthesia, and pain relieving.
Giant typhonium rhizome: pungent and sweet in flavor, warm in nature, entering stomach and liver meridians. Has effects in expelling pathogenic wind, removing phlegm, dredging channels and collaterals, removing toxic materials, and relieving pain. It can be used for treating apoplexy, phlegm stagnation, facial distortion, migraine, tetanus, venomous snake bite, scrofula, tuberculosis, and carbuncle.
Rhubarb: bitter taste and cold nature; it enters spleen, stomach, large intestine and liver meridians. Has the effects of purging, eliminating pathogenic accumulation, clearing away heat and toxic materials, cooling blood, removing blood stasis, and dredging channels. Can be used for treating constipation due to stagnation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, pyocutaneous disease, burn, scald, blood stasis, dysentery due to damp-heat, jaundice, and stranguria.
Tea tree essential oil: the extract of Camellia sinensis has antibacterial, antiinflammatory, pore astringing, common cold, cough, rhinitis, asthma treating, dysmenorrhea improving, menoxenia and genital infection improving effects.
Cinnamon essential oil: has effects in improving poor circulation, relieving muscle spasm and rheumatism, relieving arthralgia, and resisting bacteria.
Myrrh essential oil: has effects in relaxing muscles and tendons, promoting blood circulation, dispelling blood stasis, relieving pain, promoting granulation, resisting mildew, and killing bacteria.
It is worth noting that, from the perspective of traditional Chinese medicines, the scheme selects the prescription according to monarch, minister, assistant and guide, and achieves the effect of quickly relieving pain through the compatibility of the whole formula in the traditional Chinese medicine carrier. More importantly, the asarum has an obvious inhibition effect on the central nervous system by virtue of volatile oil contained in the asarum, so that a strong analgesic effect is realized, but the problem that the asarum has a certain toxicity to the kidney is not solved, and the kidney toxicity of the asarum is reduced by using the rhizoma gastrodiae and the asarum in a matching manner in the scheme, so that the effect of quickly relieving the pain under the condition of avoiding the damage to the kidney of a patient is achieved.
From the function analysis, the scheme prepares the liposome by the lecithin, the compound essential oil and the traditional Chinese medicine carrier, effectively utilizes the synergistic effect of the liposome and moxibustion thermotherapy to improve the permeation effect of the medicine components, and particularly, when the liposome is in an environment with the membrane phase transition temperature higher than that, the local high temperature strengthens the motion of phospholipid molecules, the structure of a liposome membrane is changed, and at the moment, the regularly and compactly arranged colloid-crystalline state phospholipid bilayers are changed into a loose and disordered liquid crystal state at a higher temperature, so that the medicine is released, and the effects of improving the curative effect, reducing the toxic and side effects and enhancing the targeting property are achieved.
Meanwhile, the scheme utilizes the characteristics that the medicinal moxibustion can release heat and rapidly heat up when in use, and the compound essential oil is added into the liposome. On one hand, the medicinal moxibustion device can automatically adjust volatilization and release of different components of essential oil (namely tea tree essential oil, cinnamon essential oil and myrrh essential oil) according to the temperature during heating, so that the effect that each component of essential oil acts on a patient in sequence is achieved; on the other hand, when the temperature rises too fast, the volatilization of each component essential oil can take away a part of body surface heat, has reached effective control service temperature to avoid the high temperature to bring the effect of discomfort or injury for the patient.
Compared with the prior art, the invention provides a medicinal moxibustion with quick effect and analgesic function and a preparation method thereof, and the medicinal moxibustion has the following beneficial effects:
1. the medicinal moxibustion with quick response and analgesic function provided by the invention is composed of monarch, minister, assistant and guide components, and achieves the effect of quick analgesia through the compatibility of the whole formula in the traditional Chinese medicine carrier. More importantly, the rhizoma gastrodiae and the asarum are matched for use, so that the nephrotoxicity of the asarum is reduced, and the effect of quickly relieving pain is achieved under the condition of avoiding damage to the kidney of a patient.
2. According to the medicinal moxibustion with the rapid effect and the pain relieving function, the liposome is prepared from the lecithin, the compound essential oil and the traditional Chinese medicine carrier, and the permeation effect of the medicine components is improved by effectively utilizing the synergistic effect of the liposome and moxibustion thermotherapy, so that the effects of improving the curative effect, reducing the toxic and side effects and enhancing the targeting property are achieved.
3. The medicinal moxibustion with the rapid effect and the analgesic function utilizes the characteristics that the medicinal moxibustion can release heat and rapidly heat when in use, and the liposome is added with the compound essential oil. On one hand, the medicinal moxibustion device can automatically adjust the volatilization and release of essential oil with different components according to the temperature during temperature rise, so that the effect that the essential oil with various components acts on a patient in sequence is achieved; on the other hand, when the temperature rises too fast, the volatilization of each component essential oil can take away a part of body surface heat, has reached effective control service temperature to avoid the high temperature to bring the effect of discomfort or injury for the patient.
4. According to the medicinal moxibustion with the rapid effect and the analgesia function, the coupling agent is added into the heating agent, and is usually added into a film coating agent or an ointment in medical examination, and the coupling agent is creatively added into the gel heating agent in the scheme, so that the product is in closer contact with the skin by utilizing the coupling, conduction and osmosis effects of the gel heating agent, the energy is efficiently and uniformly absorbed by the skin and tissues, the synergistic effect of coupling, conduction and osmosis is achieved, the defects that the traditional process and the simple skin osmosis absorption principle are commonly adopted in patches in the market are overcome, and the effects of accelerating the treatment speed and taking effect quickly are achieved.
5. According to the medicinal moxibustion with the rapid effect and the pain relieving function, the acupuncture points are locally heated through the heating bag, capillaries are expanded, and blood circulation and tissue metabolism are accelerated; the couplant is applied, so that energy is efficiently and uniformly absorbed by skin and tissues, and the couplant has the effects of coupling, conduction and permeation; it can be applied to skin and subcutaneous tissue to promote molecular movement in cell and accelerate metabolism, thereby repairing damaged tissue.
Detailed Description
The technical solutions of the present invention are described in further detail below, but the scope of the present invention is not limited to the following.
Example 1
1. A medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch. The heating bag comprises a material bag and a heating agent placed in the material bag; the plaster comprises a medicine bag and liposome placed in the medicine bag.
Specifically, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer. The first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged.
The heat generating agent comprises 40 parts by weight of iron powder, 10 parts by weight of water gel, 4 parts by weight of diatomite, 10 parts by weight of catalyst and 5 parts by weight of coupling agent. Wherein the water-gel comprises 1 part of super absorbent resin, 2 parts of salt and 10 parts of water in parts by weight; the coupling agent comprises 1 part of polyethylene glycol, 8 parts of vaseline, 8 parts of monoglyceride, 0.5 part of polyvinylpyrrolidone and 8 parts of lanolin.
The liposome comprises 10 parts by weight of lecithin, 18 parts by weight of compound essential oil and 50 parts by weight of traditional Chinese medicine carrier. Wherein the traditional Chinese medicine carrier comprises 40 parts of folium artemisiae argyi, 15 parts of asarum, 5 parts of rhizoma gastrodiae, 15 parts of radix angelicae, 4 parts of safflower, 1 part of rhizoma atractylodis, 4 parts of mangnolia officinalis, 3 parts of agilawood, 2 parts of radix dipsaci, 4 parts of radix aconiti, 3 parts of rhizoma typhonii and 8 parts of rheum officinale; the compound essential oil comprises 1 part of tea tree essential oil, 1 part of cinnamon essential oil and 1 part of myrrh essential oil in parts by weight.
2. A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
1) preparing liposome:
A1. weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
A2. putting the traditional Chinese medicine carrier into an ultrafine grinder for grinding and sieving to obtain ground materials of 800 meshes for later use;
A3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the compound essential oil concentration of 16g/L for later use;
A4. dissolving lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
A5. mixing the crushed materials, the mixed solution and the lipid film, setting the ultrasonic frequency to be 350MHz and the oscillation frequency to be 210rpm, and carrying out ultrasonic oscillation treatment for 15min to obtain liposome suspension;
and freeze-drying the A6 liposome suspension to obtain the liposome.
2) The preparation of the heat generating agent comprises the following steps:
B1. weighing iron powder, water gel, diatomite, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the catalyst;
3) the preparation method of the medicinal moxibustion comprises the following steps:
C1. putting the liposome into the medicine bag to obtain a plaster;
C2. putting the heating agent into a material bag to obtain a heating bag;
C3. and (5) mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
Example 2
1. A medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch. The heating bag comprises a material bag and a heating agent placed in the material bag; the plaster comprises a medicine bag and liposome placed in the medicine bag.
Specifically, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer. The first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged.
The heat generating agent comprises 80 parts by weight of iron powder, 30 parts by weight of water gel, 10 parts by weight of diatomite, 20 parts by weight of catalyst and 10 parts by weight of coupling agent. Wherein the water-gel comprises 2 parts of super absorbent resin, 4 parts of salt and 20 parts of water in parts by weight; the coupling agent comprises 2 parts of polyethylene glycol, 15 parts of vaseline, 10 parts of monoglyceride, 1 part of polyvinylpyrrolidone and 12 parts of lanolin.
The liposome comprises 25 parts by weight of lecithin, 24 parts by weight of compound essential oil and 62 parts by weight of traditional Chinese medicine carrier. Wherein the traditional Chinese medicine carrier comprises 90 parts of folium artemisiae argyi, 25 parts of asarum, 8 parts of rhizoma gastrodiae, 25 parts of radix angelicae, 8 parts of safflower, 8 parts of rhizoma atractylodis, 8 parts of mangnolia officinalis, 6 parts of agilawood, 5 parts of radix dipsaci, 8 parts of radix aconiti, 6 parts of rhizoma typhonii and 16 parts of rheum officinale; the compound essential oil comprises, by weight, 3 parts of tea tree essential oil, 3 parts of cinnamon essential oil and 3 parts of myrrh essential oil.
2. A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
1) preparing liposome:
A1. weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
A2. putting the traditional Chinese medicine carrier into an ultrafine grinder for grinding and sieving to obtain 1000-mesh ground materials for later use;
A3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the concentration of the compound essential oil being 25g/L for later use;
A4. dissolving lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
A5. mixing the crushed materials, the mixed solution and the lipid film, setting the ultrasonic frequency to be 380MHz and the oscillation frequency to be 220rpm, and carrying out ultrasonic oscillation treatment for 30min to obtain liposome suspension;
and freeze-drying the A6 liposome suspension to obtain the liposome.
2) The preparation of the heat generating agent comprises the following steps:
B1. weighing iron powder, water gel, diatomite, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the catalyst;
3) the preparation method of the medicinal moxibustion comprises the following steps:
C1. putting the liposome into the medicine bag to obtain a plaster;
C2. putting the heating agent into a material bag to obtain a heating bag;
C3. and (5) mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
Example 3
1. A medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch. The heating bag comprises a material bag and a heating agent placed in the material bag; the plaster comprises a medicine bag and liposome placed in the medicine bag.
Specifically, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer. The first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged.
The heat generating agent comprises 50 parts by weight of iron powder, 15 parts by weight of water gel, 6 parts by weight of diatomite, 13 parts by weight of catalyst and 7 parts by weight of coupling agent. Wherein the water-gel comprises 1.2 parts of super absorbent resin, 2.5 parts of salt and 12 parts of water in parts by weight; the coupling agent comprises 1.2 parts of polyethylene glycol, 10 parts of vaseline, 8.5 parts of monoglyceride, 0.6 part of polyvinylpyrrolidone and 9 parts of lanolin.
The liposome comprises 15 parts by weight of lecithin, 20 parts by weight of compound essential oil and 54 parts by weight of traditional Chinese medicine carrier. Wherein the traditional Chinese medicine carrier comprises 60 parts of folium artemisiae argyi, 18 parts of asarum, 6 parts of rhizoma gastrodiae, 18 parts of radix angelicae, 5 parts of safflower, 3 parts of rhizoma atractylodis, 6 parts of mangnolia officinalis, 4 parts of agilawood, 3 parts of radix dipsaci, 6 parts of radix aconiti, 4 parts of rhizoma typhonii and 10 parts of rheum officinale; the compound essential oil comprises, by weight, 1.5 parts of tea tree essential oil, 1.5 parts of cinnamon essential oil and 1.5 parts of myrrh essential oil.
2. A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
1) preparing liposome:
A1. weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
A2. pulverizing the traditional Chinese medicine carrier in a superfine pulverizer, and sieving to obtain 850 mesh pulverized material for later use;
A3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the compound essential oil concentration of 18g/L for later use;
A4. dissolving lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
A5. mixing the crushed materials, the mixed solution and the lipid film, setting the ultrasonic frequency to be 360MHz and the oscillation frequency to be 212rpm, and carrying out ultrasonic oscillation treatment for 18min to obtain liposome suspension;
and freeze-drying the A6 liposome suspension to obtain the liposome.
2) The preparation of the heat generating agent comprises the following steps:
B1. weighing iron powder, water gel, diatomite, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the catalyst;
3) the preparation method of the medicinal moxibustion comprises the following steps:
C1. putting the liposome into the medicine bag to obtain a plaster;
C2. putting the heating agent into a material bag to obtain a heating bag;
C3. and (5) mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
Example 4
1. A medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch. The heating bag comprises a material bag and a heating agent placed in the material bag; the plaster comprises a medicine bag and liposome placed in the medicine bag.
Specifically, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer. The first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged.
The heat generating agent comprises 60 parts by weight of iron powder, 20 parts by weight of water gel, 7.5 parts by weight of diatomite, 15 parts by weight of catalyst and 8 parts by weight of coupling agent. Wherein the water-gel comprises 1.5 parts of super absorbent resin, 3 parts of salt and 15 parts of water in parts by weight; the coupling agent comprises 1.5 parts of polyethylene glycol, 12 parts of vaseline, 9 parts of monoglyceride, 0.7 part of polyvinylpyrrolidone and 10 parts of lanolin.
The liposome comprises 18 parts of lecithin, 21 parts of compound essential oil and 56 parts of traditional Chinese medicine carriers in parts by weight. Wherein, the traditional Chinese medicine carrier comprises 65 parts of folium artemisiae argyi, 20 parts of asarum, 7 parts of rhizoma gastrodiae, 20 parts of radix angelicae, 6 parts of safflower, 5 parts of rhizoma atractylodis, 8 parts of mangnolia officinalis, 4.5 parts of agilawood, 3.5 parts of radix dipsaci, 7 parts of radix aconiti, 4.5 parts of rhizoma typhonii and 12 parts of rheum officinale; the compound essential oil comprises, by weight, 2 parts of tea tree essential oil, 2 parts of cinnamon essential oil and 2 parts of myrrh essential oil.
2. A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
1) preparing liposome:
A1. weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
A2. putting the traditional Chinese medicine carrier into an ultrafine grinder for grinding and sieving to obtain ground material of 900 meshes for later use;
A3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the concentration of the compound essential oil being 20g/L for later use;
A4. dissolving lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
A5. mixing the crushed material and the mixed solution with a lipid film, setting the ultrasonic frequency to be 370MHz and the oscillation frequency to be 215rpm, and carrying out ultrasonic oscillation treatment for 22min to obtain a liposome suspension;
and freeze-drying the A6 liposome suspension to obtain the liposome.
2) The preparation of the heat generating agent comprises the following steps:
B1. weighing iron powder, water gel, diatomite, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the catalyst;
3) the preparation method of the medicinal moxibustion comprises the following steps:
C1. putting the liposome into the medicine bag to obtain a plaster;
C2. putting the heating agent into a material bag to obtain a heating bag;
C3. and (5) mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
Example 5
1. A medicinal moxibustion with rapid action and analgesic effect comprises a heating bag and a plaster patch. The heating bag comprises a material bag and a heating agent placed in the material bag; the plaster comprises a medicine bag and liposome placed in the medicine bag.
Specifically, the material bag is formed by sewing a first film non-woven fabric layer and a first breathable film layer, and the medicine bag is formed by sewing a second film non-woven fabric layer and a second breathable film layer. The first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged.
The heat generating agent comprises 70 parts of iron powder, 25 parts of water gel, 8 parts of diatomite, 18 parts of catalyst and 9 parts of coupling agent by weight. Wherein the water-gel comprises 1.8 parts of super absorbent resin, 3.5 parts of salt and 18 parts of water by weight; the coupling agent comprises 1.8 parts of polyethylene glycol, 12 parts of vaseline, 9.5 parts of monoglyceride, 0.8 part of polyvinylpyrrolidone and 11 parts of lanolin.
The liposome comprises 22 parts by weight of lecithin, 22 parts by weight of compound essential oil and 60 parts by weight of traditional Chinese medicine carrier. Wherein the traditional Chinese medicine carrier comprises 80 parts of folium artemisiae argyi, 20 parts of asarum, 7 parts of rhizoma gastrodiae, 22 parts of radix angelicae, 7 parts of safflower, 7 parts of rhizoma atractylodis, 8 parts of mangnolia officinalis, 5 parts of agilawood, 4 parts of radix dipsaci, 8 parts of radix aconiti, 6 parts of rhizoma typhonii and 15 parts of rheum officinale; the compound essential oil comprises, by weight, 3 parts of tea tree essential oil, 3 parts of cinnamon essential oil and 2 parts of myrrh essential oil.
2. A preparation method of medicinal moxibustion with quick action and analgesic effect comprises the following steps:
1) preparing liposome:
A1. weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
A2. putting the traditional Chinese medicine carrier into an ultrafine grinder for grinding and sieving to obtain 950-mesh ground materials for later use;
A3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the compound essential oil concentration of 24g/L for later use;
A4. dissolving lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
A5. mixing the crushed materials, the mixed solution and the lipid film, setting the ultrasonic frequency to be 360MHz and the oscillation frequency to be 218rpm, and carrying out ultrasonic oscillation treatment for 28min to obtain liposome suspension;
and freeze-drying the A6 liposome suspension to obtain the liposome.
2) The preparation of the heat generating agent comprises the following steps:
B1. weighing iron powder, water gel, diatomite, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the catalyst;
3) the preparation method of the medicinal moxibustion comprises the following steps:
C1. putting the liposome into the medicine bag to obtain a plaster;
C2. putting the heating agent into a material bag to obtain a heating bag;
C3. and (5) mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
Comparative example 1
The moxibustion with the drugs of the invention in the example 1 is compared with the control example 1, and the difference between the control example 1 and the example 1 is as follows:
1. the liposome does not contain compound essential oil;
2. the preparation method does not contain the step A3;
3. in the preparation method, step A1 is to weigh the lecithin and the traditional Chinese medicine carrier according to the mixture ratio;
4. in the preparation method, step A5 is mixing the crushed material with a lipid film, setting the ultrasonic frequency to be 350MHz and the oscillation frequency to be 210rpm, and carrying out ultrasonic oscillation treatment for 15min to obtain liposome suspension;
the dosage, procedure and conditions are the same as those in example 1 of the present invention (in this comparative example, compared to example 1, no complex essential oil is added to the liposome, which is used to prove that the moxibustion effect of the present invention is better).
Comparative example 2
The moxibustion with the drugs of the invention in example 1 is compared with the control example 2, and the difference between the control example 2 and example 1 is as follows:
1. replacing the liposome with ointment;
2. the preparation method of the ointment body comprises the following steps:
D1. weighing the compound essential oil and the traditional Chinese medicine carrier according to the proportion;
D2. putting the traditional Chinese medicine carrier into an ultrafine grinder for grinding and sieving to obtain ground materials of 800 meshes for later use;
D3. mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution with the compound essential oil concentration of 18 g/L;
D4. mixing the crushed materials with the mixed solution, setting the ultrasonic frequency to be 350MHz and the oscillation frequency to be 210rpm, and carrying out ultrasonic oscillation treatment for 15min to obtain a suspension;
D5. freeze drying the suspension to obtain ointment;
the amounts, steps and conditions were the same as those in example 1 of the present invention (in this comparative example, no liposome was prepared as compared with example 1, and it was confirmed that the moxibustion effect of the present invention was better).
Test effects
1. In order to verify the temperature control effect of the medicinal moxibustion, a comparison test is carried out in a physical therapy center. In the experiment, patients of 20-70 years old are divided into 7 groups, 3 patients in each group are treated by adopting the medicinal moxibustion of the examples 1-5 and the comparative examples 1-2 respectively for 1h, the body surface temperature of the treatment position of the patient is tested by adopting a temperature measuring gun after the treatment is finished, and the skin condition of the treatment position is observed. The results are shown in the following table:
as can be seen from the above table, in examples 1-5 and comparative example 2, the body surface temperature of the patients after the treatment is between 42 ℃ and 45 ℃, and the skin does not turn red obviously; in contrast, in comparative example 1, the body surface temperature of the patient was between 52 ℃ and 54 ℃ after the treatment, and the skin appeared to be significantly reddened and not to be faded for a long time.
Therefore, the temperature can be effectively controlled when the medicinal moxibustion is used, so that discomfort and even injury to a patient caused by high temperature are avoided.
2. In order to verify the therapeutic effect of the medicinal moxibustion, a comparative test is carried out in a physical therapy center. In the experiment, patients in 20-70 years old who need to be subjected to analgesic treatment are divided into 7 groups, 50 patients in each group are treated by adopting the medicinal moxibustion of the examples 1-5 and the comparative examples 1-2 for 1 hour, and the curative effect is determined after the treatment is finished.
The therapeutic effect judgment refers to the therapeutic effect judgment standard formulated from the clinical disease diagnosis treatment improvement standard and the traditional Chinese medicine disease diagnosis therapeutic effect standard, and the therapeutic effect judgment is carried out according to the therapeutic effect index and the clinical diagnosis result.
a) And (3) healing: after treatment, the malaise symptoms disappeared: .
b) The effect is shown: after treatment, discomfort symptoms were significantly relieved:
c) the method has the following advantages: after treatment, discomfort symptoms were relieved to some extent:
d) and (4) invalidation: after treatment, the discomfort symptoms are not relieved or even worsened.
The results are shown in the following table:
as can be seen from the table, the cure rate of the embodiments 1-5 is higher than 20%, and the significant efficiency is higher than 45%; the cure rate and the significant efficacy rate were slightly decreased in comparative example 1, and significantly decreased in comparative example 2, as compared to example 1. The reason is that the addition of the liposome can shorten the onset time, thereby ensuring that the moxibustion takes effect quickly; the addition of the compound essential oil can also have a synergistic effect with the liposome, thereby further shortening the onset time and improving the curative effect.
In conclusion, the medicinal moxibustion with quick response and analgesic function and the preparation method thereof achieve the analgesic effect under the conditions of quick response, effective temperature control and green safety.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A medicinal moxibustion with rapid onset of drug action and analgesic effect is characterized by comprising a heating bag and a plaster; the heating bag comprises a heating agent and a material bag, and the plaster comprises liposome and a medicine bag;
the liposome comprises, by weight, 10-25 parts of lecithin, 18-24 parts of compound essential oil and 50-62 parts of a traditional Chinese medicine carrier;
the traditional Chinese medicine carrier comprises, by weight, 40-90 parts of folium artemisiae argyi, 15-25 parts of asarum, 5-8 parts of rhizoma gastrodiae, 15-25 parts of radix angelicae, 4-8 parts of safflower, 1-8 parts of rhizoma atractylodis, 4-8 parts of mangnolia officinalis, 3-6 parts of agilawood, 2-5 parts of radix dipsaci, 4-8 parts of radix aconiti, 3-6 parts of rhizoma typhonii and 8-16 parts of rheum officinale.
2. The moxibustion with a drug having a fast onset of action and an analgesic function of claim 1, wherein the compound essential oil comprises, by weight, 1 to 3 parts of tea tree essential oil, 1 to 3 parts of cinnamon essential oil, and 1 to 3 parts of myrrh essential oil.
3. The moxibustion with rapid onset of action and analgesic effect of claim 1, wherein the liposome is prepared by the following steps:
s1, weighing lecithin, compound essential oil and a traditional Chinese medicine carrier according to a ratio;
s2, crushing and screening the traditional Chinese medicine carrier to obtain crushed materials of 800-1000 meshes for later use;
s3, mixing the compound essential oil with a phosphate buffer solution to obtain a mixed solution for later use;
s4, dissolving the lecithin in absolute ethyl alcohol, and performing rotary steaming and drying treatment to obtain a uniform and continuous lipid film;
s5, mixing the crushed material and the mixed solution with a lipid film, and carrying out ultrasonic oscillation treatment to obtain a liposome suspension;
s6, freeze-drying the liposome suspension to obtain the liposome.
4. The moxibustion with a drug and an analgesic function as claimed in claim 3, wherein in S3, the concentration of the compound essential oil in the mixed solution is 16-25 g/L.
5. The moxibustion with quick acting and analgesic function of claim 3, wherein in S5, the ultrasonic oscillation treatment time is 15-30 min; the frequency of the ultrasonic wave is 350-380 MHz, and the frequency of the oscillation is 210-220 rpm.
6. The moxibustion with the function of fast onset and analgesia as claimed in claim 1, wherein the heat generating agent comprises 40-80 parts by weight of iron powder, 10-30 parts by weight of water gel, 4-10 parts by weight of diatomite, 10-20 parts by weight of catalyst and 5-10 parts by weight of coupling agent.
7. The moxibustion with quick-acting and analgesic functions of claim 6, wherein the hydrocolloid comprises 1-2 parts by weight of super absorbent resin, 2-4 parts by weight of salt and 10-20 parts by weight of water;
the coupling agent comprises, by weight, 1-2 parts of polyethylene glycol, 8-15 parts of vaseline, 8-10 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 8-12 parts of lanolin.
8. The moxibustion device of claim 6, wherein the heating agent is prepared by weighing the iron powder, the hydrocolloid, the diatomaceous earth, the catalyst and the coupling agent according to a certain ratio, and mixing them uniformly.
9. The moxibustion device of claim 1, wherein the pouch is made of a first laminated non-woven fabric layer and a first breathable film layer, and the pouch is made of a second laminated non-woven fabric layer and a second breathable film layer; the first laminating non-woven fabric layer and the second laminating non-woven fabric layer are bonded with each other; pressure-sensitive adhesive is arranged on the first breathable film layer and the second breathable film layer, and release paper is arranged on the first breathable film layer and the second breathable film layer.
10. A method for preparing a rapid-onset analgesic moxibustion as claimed in any one of claims 1 to 9, comprising the steps of:
s7, putting the liposome into a medicine bag to obtain the ointment paste;
s8, putting the heating agent into a material bag to obtain the heating bag;
s9, mutually bonding the ointment patch and the heating bag to obtain the medicinal moxibustion.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023236241A1 (en) * | 2022-06-09 | 2023-12-14 | 河南省中医院（河南中医药大学第二附属医院） | Medium for analgesic moxibustion with seed-sized moxa cones and method for preparing same |
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