CN111929452B - Sample detection device, reagent replacement method thereof and computer storage medium - Google Patents

Sample detection device, reagent replacement method thereof and computer storage medium Download PDF

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Publication number
CN111929452B
CN111929452B CN201910395267.8A CN201910395267A CN111929452B CN 111929452 B CN111929452 B CN 111929452B CN 201910395267 A CN201910395267 A CN 201910395267A CN 111929452 B CN111929452 B CN 111929452B
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reagent
time
target
point
idle
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CN111929452A (en
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李恒
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/0092Scheduling
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/0092Scheduling
    • G01N2035/0094Scheduling optimisation; experiment design

Abstract

The application discloses a sample detection device, a reagent replacement method thereof and a computer storage medium, wherein the method comprises the following steps: acquiring an idle time period of a reagent storage bin in a sample detection process; wherein, the idle time period is a time period without adding a reagent in the sample detection process; the reagent in the reagent storage bin is replaced in an idle time period. By means of the mode, the reagent can be replaced under the condition that the detection device does not shut down, and the working efficiency of the detection device is improved.

Description

Sample detection device, reagent replacement method thereof and computer storage medium
Technical Field
The present disclosure relates to the field of testing technologies, and in particular, to a sample testing device, a reagent replacing method thereof, and a computer storage medium.
Background
In the field of medical testing, there are a variety of testing devices used to test samples. The detection device comprises a reagent storage cabin, and the reagent storage cabin is used for storing various reagents so as to add the reagents when a sample is detected.
In the prior art, when the reagent is to be replaced, the detection device is generally shut down to stop detection, and then the reagent can be replaced.
Disclosure of Invention
In order to solve the above problems, the present application provides a sample detection device, a reagent replacement method thereof, and a computer storage medium, which can replace a reagent without stopping the detection device, thereby improving the working efficiency of the detection device.
The technical scheme adopted by the application is as follows: provided is a reagent replacement method for a sample detection device, the method including: acquiring an idle time period of a reagent storage bin in a sample detection process; the idle time period is a time period in which no reagent is required to be added in the sample detection process; and replacing the reagent in the reagent storage bin in an idle time period.
Wherein, in the sample testing process, the step of obtaining the idle time section of the reagent storage bin comprises: obtaining a detection process of a sample; determining a first time point when the target agent is depleted; determining a second time point after the first time point at which reagent addition is required; a first idle period of time of the reagent storage compartment is determined based on a length of time between the first point in time and the second point in time.
Wherein the step of determining a first point in time when the target agent is depleted comprises: obtaining the surplus of the target reagent; acquiring the adding time point and each adding amount of the target reagent; and determining a first time point when the target reagent is exhausted according to the residual quantity of the target reagent, the adding time point and each adding amount.
Wherein the step of determining a second time point after the first time point at which reagent is to be added comprises: acquiring the adding time point of each reagent in the detection process; from the point in time of addition, a second point in time after the first point in time at which addition of reagent is desired is determined.
Wherein, the step of changing the reagent in the reagent storage storehouse in the idle time quantum includes: judging whether the replacement time length of the target reagent is less than a first idle time period or not; if yes, the target reagent in the reagent storage bin is replaced in the first idle time period.
Wherein, the method further comprises: if the replacement time length of the target reagent is greater than the first idle time period, determining a third time point needing to be added with the reagent after the second time point; determining a second idle period of time for the reagent storage bin based on the length of time between the second time point and the third time point; judging whether the replacement time length of the target reagent is less than a second idle time period or not; if yes, the target reagent in the reagent storage bin is replaced in the second idle time period.
Wherein, the method also comprises: and if the target reagent needs to be added before the idle time period with the time length longer than the replacement time length of the target reagent is found, stopping the machine before the target reagent is added.
Wherein, the step of changing the reagent in the reagent storage storehouse in the idle time quantum includes: when the idle time period begins, an alarm is given to prompt the user to replace the reagent.
Another technical scheme adopted by the application is as follows: there is provided a sample testing device comprising a processor and a memory electrically connected to the processor, the memory for storing program data and the processor for executing the program data to implement a method as described above.
Another technical scheme adopted by the application is as follows: a computer storage medium is provided for storing program data for implementing the method as described above when executed by a processor.
The present application provides a reagent replacement method for a sample detection device, including: acquiring an idle time period of a reagent storage bin in a sample detection process; wherein, the idle time period is a time period without adding a reagent in the sample detection process; the reagent in the reagent storage bin is replaced in an idle time period. By the mode, the reagent can be replaced under the condition that the detection device does not shut down, the working efficiency of the detection device is improved, and the normal detection work of the detection device cannot be influenced.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic flow chart illustrating a reagent replacement method of a sample testing device according to an embodiment of the present disclosure;
FIG. 2 is a second schematic flow chart of a reagent replacing method for a sample testing device according to an embodiment of the present disclosure;
FIG. 3 is a third schematic flow chart of a reagent replacing method of the sample testing device according to the embodiment of the present application;
FIG. 4 is a schematic timing diagram provided in an embodiment of the present application;
FIG. 5 is a schematic structural diagram of a sample detection device provided in an embodiment of the present application;
fig. 6 is a schematic structural diagram of a computer storage medium provided in an embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terms "first", "second", etc. in this application are used to distinguish between different objects and not to describe a particular order. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein may be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic flow chart of a reagent replacing method of a sample testing device according to an embodiment of the present application, the method including:
step 11: acquiring an idle time period of a reagent storage bin in a sample detection process; wherein, the idle time period is a time period without adding reagent in the sample detection process.
In the sample detection process, adding reagents is an indispensable step. Generally, the time taken for adding the reagent is very short, and in this embodiment, the length of time for adding the reagent is ignored, and it is assumed that the reagent addition can be completed at one time point.
There may be a certain length of idle time between two additions of the same reagent or of different reagents, during which no reagent needs to be added. For example, the detection device may perform other detection operations such as stirring, washing, etc. during the idle period.
Step 12: the reagent in the reagent storage bin is replaced in an idle time period.
Optionally, step 12 may specifically include: at the beginning of the idle period, an alarm is issued to prompt the user to change the reagent. Specifically, the alarm device can be a voice alarm, a vibration alarm, a flashing alarm and the like. The door of the reagent storage bin can also be directly opened so as to replace the reagent.
Referring to fig. 2, fig. 2 is a second schematic flow chart of a reagent replacing method of a sample testing device according to an embodiment of the present application, the method including:
step 21: and (5) obtaining a detection process of the sample.
In some detection devices, multiple samples may be detected in parallel. The detection device presets a timing sequence to schedule the detection of the sample. The time point at which the reagent is added during the detection of each sample can be determined directly from the timing of the schedule.
Step 22: a first time point at which the target agent is depleted is determined.
Wherein step 22 may comprise: obtaining the surplus of a target reagent; acquiring the adding time point and each adding amount of the target reagent; and determining a first time point when the target reagent is exhausted according to the residual quantity of the target reagent, the adding time point and each adding amount.
For example, in the present embodiment, the remaining amount of the target reagent is X, and after the target reagent is added once, the remaining amount is updated to X-1, and so on.
If the remaining amount of the target reagent at the present time is 1, and the target reagent needs to be added at the next time point a, it may be determined that the time point a is the first time point at which the target reagent is exhausted.
Step 23: a second time point after the first time point at which reagent addition is required is determined.
Acquiring the adding time point of each reagent in the detection process; based on the point in time of addition, a second point in time after the first point in time is determined at which addition of the reagent is required.
If it is necessary to add a reagent at a time point b after the time a, the time point b is determined as a second time point regardless of whether the reagent necessary to be added at the time point b is the target reagent.
Step 24: a first idle period of time of the reagent storage compartment is determined based on a length of time between the first point in time and the second point in time.
The length of time between the point of time a and the point of time b is determined as a first idle period.
Step 25: the target reagent in the reagent storage bin is replaced in an idle time period.
Referring to fig. 3, fig. 3 is a third schematic flow chart of a reagent replacing method of a sample testing device according to an embodiment of the present application, the method including:
step 31: and (5) obtaining a detection process of the sample.
Step 32: a first time point at which the target agent is depleted is determined.
Step 33: a second time point after the first time point at which reagent addition is required is determined.
Step 34: a first idle period of time of the reagent storage compartment is determined based on a length of time between the first point in time and the second point in time.
Step 35: and judging whether the replacement time length of the target reagent is less than the first idle time period.
As shown in fig. 4, fig. 4 is a schematic diagram of time sequence coordinates provided in the embodiment of the present application, wherein the abscissa represents time sequence, the upper part of the abscissa represents the addition time point of reagent a and the residual amount after addition, and the lower part of the abscissa represents the addition time point of reagent B and the residual amount after addition.
T1 between a first time point from the time point when the remaining amount of the reagent a is 0 and a second time point when the reagent B needs to be added later is determined as a first idle period.
Step 36: the target reagent in the reagent storage bin is replaced in the first idle time period.
And if the replacement time length of the target reagent is less than the first idle time period t1, replacing the reagent in the first idle time period t 1. It will be appreciated that in order to save time and to change the reagent quickly, the reagent can be changed immediately at the beginning of the first idle period t 1. Of course, the replacement may also be started at any time within the first idle period t1, but it must be ensured that the replacement of reagent a is completed before reagent B is added.
In addition, if the replacement time length of the target reagent is greater than the first idle time period, determining a third time point which is after the second time point and needs to be added with the reagent; determining a second idle period of time for the reagent storage bin based on the length of time between the second time point and the third time point; judging whether the replacement time length of the target reagent is less than a second idle time period or not; if yes, the target reagent in the reagent storage bin is replaced in the second idle time period.
As shown in fig. 4, if the first idle time period t1 is less than the replacement time length of the target reagent, the second idle time period t2 after the first idle time period t1 is determined, and it is determined again whether the second idle time period t2 is less than the replacement time length of the target reagent, and if so, the target reagent in the reagent storage compartment is replaced in the second idle time period.
It will be appreciated that the time can be changed in the manner described above, with continual searching back for idle periods that meet the requirements. However, it is noted that if a time period that meets the requirements has not been found and the target reagent that has been depleted needs to be added, a shutdown is required for replacement.
Different from the prior art, the reagent replacing method of the sample detection device provided in this embodiment includes: acquiring an idle time period of a reagent storage bin in a sample detection process; wherein, the idle time period is a time period without adding a reagent in the sample detection process; the reagent in the reagent storage bin is replaced in an idle time period. By the above mode, the reagent can be replaced under the condition that the detection device does not shut down, the working efficiency of the detection device is improved, and the normal detection work of the detection device cannot be influenced.
Referring to fig. 5, fig. 5 is a schematic structural diagram of a sample testing device according to an embodiment of the present application, where the sample testing device 50 includes a processor 51 and a memory 52 electrically connected to the processor 51, the memory 52 is used for storing program data, and the processor 51 is used for executing the program data to implement the following method:
acquiring an idle time period of a reagent storage bin in a sample detection process; the idle time period is a time period in which no reagent is required to be added in the sample detection process; the reagent in the reagent storage bin is replaced in an idle time period.
The sample testing device 50 may be a testing device used in the medical field, such as an immunoassay analyzer.
Optionally, the processor 51 executing the program data is further for implementing the method of: obtaining a detection process of a sample; determining a first time point when the target agent is depleted; determining a second time point after the first time point at which reagent addition is required; a first idle period of time of the reagent storage compartment is determined based on a length of time between the first point in time and the second point in time.
Optionally, the processor 51 executing the program data is further for implementing the method of: obtaining the surplus of a target reagent; acquiring the adding time point and each adding amount of the target reagent; and determining a first time point when the target reagent is exhausted according to the residual quantity of the target reagent, the adding time point and each adding amount.
Optionally, the processor 51 executing the program data is further for implementing the method of: acquiring the adding time point of each reagent in the detection process; based on the point in time of addition, a second point in time after the first point in time is determined at which addition of the reagent is required.
Optionally, the processor 51 executing the program data is further for implementing the method of: judging whether the replacement time length of the target reagent is less than a first idle time period or not; if yes, the target reagent in the reagent storage bin is replaced in the first idle time period.
Optionally, the processor 51 executing the program data is further for implementing the method of: if the replacement time length of the target reagent is greater than the first idle time period, determining a third time point needing to be added with the reagent after the second time point; determining a second idle period of time for the reagent storage bin based on the length of time between the second point in time and the third point in time; judging whether the replacement time length of the target reagent is less than a second idle time period or not; if yes, the target reagent in the reagent storage bin is replaced in the second idle time period.
Optionally, the processor 51 executing the program data is further for implementing the method of: and if the target reagent needs to be added before the idle time period with the time length longer than the replacement time length of the target reagent is found, stopping the machine before the target reagent is added.
Optionally, the processor 51 executing the program data is further for implementing the method of: at the beginning of the idle period, an alarm is issued to prompt the user to change the reagent.
Referring to fig. 6, fig. 6 is a schematic structural diagram of a computer storage medium 60 for storing program data 61, where the program data 61 is used to implement the following method when executed by a processor:
acquiring an idle time period of a reagent storage bin in a sample detection process; wherein, the idle time period is a time period without adding a reagent in the sample detection process; the reagent in the reagent storage bin is replaced in an idle time period.
In the several embodiments provided in the present application, it should be understood that the disclosed method and apparatus may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, and for example, the division of the modules or units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the embodiment.
In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The integrated units in the other embodiments described above may be stored in a computer-readable storage medium if they are implemented in the form of software functional units and sold or used as separate products. Based on such understanding, the technical solution of the present application may be substantially implemented or contributed by the prior art, or all or part of the technical solution may be embodied in a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, a network device, or the like) or a processor (processor) to execute all or part of the steps of the method according to the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made according to the content of the present specification and the accompanying drawings, or which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims (6)

1. A method for replacing a reagent in a sample testing device, comprising:
obtaining a detection process of a sample;
determining a first time point when the target agent is depleted;
determining a second time point after the first time point at which reagent addition is required; wherein the target reagent and the reagent to be added are different reagents;
determining a first idle period of time for the reagent storage bin based on a length of time between the first point in time and the second point in time;
judging whether the replacement time length of the target reagent is less than the first idle time period or not;
if yes, replacing the target reagent in the reagent storage bin in the first idle time period;
if the replacement time length of the target reagent is longer than the first idle time period, determining a third time point needing to be added with the reagent after the second time point; wherein the target reagent and the reagent to be added are different reagents;
determining a second idle period of time for the reagent storage compartment based on a length of time between the second point in time and the third point in time;
judging whether the replacement time length of the target reagent is less than the second idle time period or not;
if yes, replacing the target reagent in the reagent storage bin in the second idle time period;
and if the target reagent needs to be added before the idle time period with the time length longer than the replacement time length of the target reagent is found, stopping the device before the target reagent is added.
2. The method of claim 1,
the step of determining a first point in time when the target agent is depleted comprises:
obtaining the residual amount of the target reagent; and
acquiring the adding time point and each adding amount of the target reagent;
and determining a first time point when the target reagent is exhausted according to the residual quantity of the target reagent, the adding time point and the adding amount each time.
3. The method of claim 1,
the step of determining a second time point after the first time point at which reagent addition is required comprises:
acquiring the adding time point of each reagent in the detection flow;
and determining a second time point needing to add the reagent after the first time point according to the adding time point.
4. The method of claim 1,
the step of replacing reagent in the reagent storage compartment during the idle period comprises:
at the beginning of the idle period, an alarm is raised to prompt the user to change the reagent.
5. A sample testing device comprising a processor and a memory electrically connected to the processor, the memory for storing program data, the processor for executing the program data to implement the method of any one of claims 1-4.
6. A computer storage medium for storing program data, which when executed by a processor is adapted to carry out the method of any one of claims 1 to 4.
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Citations (5)

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CN106370877A (en) * 2016-12-13 2017-02-01 安图实验仪器(郑州)有限公司 Online reagent replacement control system for full-automatic chemiluminescence immunity analyzer
CN206038705U (en) * 2016-09-22 2017-03-22 四川迈克生物医疗电子有限公司 Loading and uninstallation device of external diagnostic equipment and kit
CN106950387A (en) * 2017-03-30 2017-07-14 四川迈克生物医疗电子有限公司 Reagent changes control method, device and analytical instrument

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1550781A (en) * 2003-05-14 2004-12-01 ��ʽ�����������¼��� Automatic analyzer
CN103675248A (en) * 2012-09-21 2014-03-26 深圳迈瑞生物医疗电子股份有限公司 Biochemical analyzer as well as reagent residue refreshing method and device thereof
CN206038705U (en) * 2016-09-22 2017-03-22 四川迈克生物医疗电子有限公司 Loading and uninstallation device of external diagnostic equipment and kit
CN106370877A (en) * 2016-12-13 2017-02-01 安图实验仪器(郑州)有限公司 Online reagent replacement control system for full-automatic chemiluminescence immunity analyzer
CN106950387A (en) * 2017-03-30 2017-07-14 四川迈克生物医疗电子有限公司 Reagent changes control method, device and analytical instrument

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