CN111925935A - Sample processing and detecting multifunctional device - Google Patents

Sample processing and detecting multifunctional device Download PDF

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Publication number
CN111925935A
CN111925935A CN202010934771.3A CN202010934771A CN111925935A CN 111925935 A CN111925935 A CN 111925935A CN 202010934771 A CN202010934771 A CN 202010934771A CN 111925935 A CN111925935 A CN 111925935A
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extraction
sample
guide rail
imbibition
liquid suction
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王建平
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Guangzhou City Biotron Biotechnology Co ltd
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Guangzhou City Biotron Biotechnology Co ltd
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Sampling And Sample Adjustment (AREA)

Abstract

The invention discloses a multifunctional device for sample treatment and detection. The sample processing and detecting multifunctional device comprises a box body, an extracting mechanism, a liquid absorbing mechanism and a transmission mechanism; a plurality of mutually isolated processing chambers and a sample adding channel for adding samples are arranged in the box body; the extraction mechanism comprises an extraction guide rail and an extraction part, the extraction guide rail is arranged on the inner side wall of the box body, the extraction guide rail is partially in an up-and-down circuitous structure, the extraction part is movably connected with the extraction guide rail, and the extraction part is also connected with the transmission mechanism; imbibition mechanism includes imbibition guide rail and imbibition part, and imbibition guide rail sets up the inside wall at the box, and imbibition guide rail part position is circuitous structure from top to bottom, and imbibition part swing joint is in imbibition guide rail, and imbibition part still is connected with drive mechanism, and imbibition part still communicates with each other with the application of sample passageway. The multifunctional device for sample treatment and detection can avoid the infection of the sample and the risk of cross contamination in the detection process.

Description

Sample processing and detecting multifunctional device
Technical Field
The invention relates to the field of biological detection equipment, in particular to a multifunctional device for sample treatment and detection.
Background
In the field of biological detection, a traditional sample detection mode is to suck and transfer a sample into a detection reagent for reaction through a person or an instrument, and the traditional sample detection mode has the risk of cross contamination and has certain threat to the safety of operators.
Disclosure of Invention
Based on this, there is a need for a multifunctional device for sample processing and detection, which can reduce the risk of sample infection and cross-contamination during the detection process, and greatly improve the safety and reliability of sample detection.
A sample processing and detecting multifunctional device comprises a box body, an extracting mechanism, a liquid absorbing mechanism and a transmission mechanism;
a plurality of mutually isolated processing chambers and a sample adding channel for adding samples are arranged in the box body;
the extraction mechanism comprises an extraction guide rail and an extraction part, the extraction guide rail is arranged on the inner side wall of the box body and is positioned above the processing chamber, part of the extraction guide rail is in a first circuitous structure, the extraction part is movably connected with the extraction guide rail, and the extraction part is also connected with the transmission mechanism;
the imbibition mechanism comprises an imbibition guide rail and an imbibition component, the imbibition guide rail is arranged on the inner side wall of the box body and is positioned above the processing chamber, part of the imbibition guide rail is in a second circuitous structure, the imbibition component is movably connected with the imbibition guide rail, the imbibition component is also connected with the transmission mechanism, and the imbibition component is also communicated with the sample adding channel;
the transmission mechanism is used for being connected with an external driving mechanism.
In one embodiment, the extraction member includes an extraction column and an extraction slider, the extraction slider is movably connected to the extraction guide rail and connected to the transmission mechanism, and the extraction column is connected to the extraction slider.
In one embodiment, the extraction column comprises an extraction magnetic rod and an extraction connecting rod, the extraction magnetic rod being connected to the extraction slide by the extraction connecting rod for extracting nucleic acids from within the processing chamber.
In one embodiment, the liquid suction component comprises a liquid suction sliding component and a liquid suction assembly, the liquid suction sliding component is movably connected to the liquid suction guide rail and is connected with the transmission mechanism, and the liquid suction assembly is connected with the liquid suction sliding component.
In one embodiment, the liquid suction assembly includes a liquid suction head, a liquid suction guide tube and a liquid suction driving member, the liquid suction head is connected to the liquid suction sliding member for sucking liquid from the processing chamber, the liquid suction driving member is disposed in the box body and is communicated with the liquid suction head through the liquid suction guide tube, and the sample adding channel is communicated with the liquid suction guide tube.
In one embodiment, the dip tube is a hose.
In one embodiment, the liquid suction driving member includes a pneumatic liquid suction pump, the elastic member and a plug, the pneumatic liquid suction pump has a liquid suction pump cavity, a first pneumatic interface communicated with the liquid suction pump cavity and used for externally connecting the driving member, and a second pneumatic interface communicated with the liquid suction conduit, the elastic member is disposed in the liquid suction pump cavity, the plug is movably disposed in the liquid suction pump cavity and hermetically engaged with an inner wall of the liquid suction pump cavity, and the sample adding channel is communicated with the liquid suction pump cavity.
In one embodiment, the transmission mechanism is a transmission screw rod, the extraction component is in threaded connection with the transmission mechanism, and the liquid suction component is in threaded connection with the transmission mechanism.
In one embodiment, the box body comprises a base and a shell, the processing chamber is arranged on the base, the shell covers the base and is connected with the base in a sealing manner, and the sample adding channel is arranged on the shell.
In one embodiment, the box body is further provided with a sample loading hole cover, and the sample loading hole cover is used for sealing the sample loading channel.
In one embodiment, the inner surface of the sample-adding hole cover has an inverted structure, and when the sample-adding hole cover is covered on the outward-facing channel opening of the sample-adding channel, the inverted structure is buckled on the inner wall of the channel opening.
In one embodiment, at least one side of the base is provided with a supporting arm protruding upwards, the top of the supporting arm is provided with the sample adding channel, the shell is provided with a sample adding hole, the shell is covered on the back of the base, the sample adding hole is communicated with the sample adding channel, and the inverted structure can realize the connection between the shell and the supporting arm after the sample adding hole is covered by the sample adding hole cover.
The processing chambers are distributed in sequence along the transmission direction of the transmission mechanism.
In one embodiment, the first bypass structure and the second bypass structure are both located above the processing chamber, and/or the first bypass structure and the second bypass structure are disposed in a staggered manner.
The multifunctional device for sample treatment and detection provided by the invention has the advantages that the box body, the extraction mechanism, the liquid suction mechanism and the transmission mechanism are matched with each other, so that the risks of sample infection and cross contamination in the detection process can be avoided, and the safety and reliability of sample detection are greatly improved. The invention provides a multifunctional device for sample processing and detection. Specifically, in the invention, a plurality of mutually isolated processing chambers are arranged in the box body, each processing chamber is used for storing the solution with the corresponding function and participating in the reaction, and the corresponding solution transfer and reaction are realized under the coordination of different components such as an extraction mechanism, a liquid suction mechanism and the like. The extracting component of the extracting mechanism can move along the transmission mechanism and the extracting guide rail according to a preset rail under the transmission action of the transmission mechanism, on one hand, the extracting component can horizontally move through the transmission action of the transmission mechanism, and on the other hand, the extracting component can vertically reciprocate under the limiting action of the first circuitous structure of the extracting guide rail to complete corresponding functions. In a similar way, the liquid absorbing component of the liquid absorbing mechanism moves along the transmission mechanism and the liquid absorbing guide rail according to a preset rail under the transmission action of the transmission mechanism, on one hand, the liquid absorbing component realizes horizontal movement through the transmission action of the transmission mechanism, and on the other hand, the liquid absorbing component also realizes vertical reciprocating movement under the limiting action of a second circuitous structure of the liquid absorbing guide rail so as to complete corresponding functions. The transmission mechanism is connected with the external driving mechanism to realize horizontal transmission of the extraction component and the liquid suction component so as to finish the movement of the extraction component and the liquid suction component according to a preset track. The invention simplifies each component, increases the matching of each component inside, such as an extraction component and a liquid absorption component, creatively guides the extraction component to move up and down through the circuitous structure of the extraction guide rail, guides the liquid absorption component to move up and down through the circuitous structure of the liquid absorption guide rail, does not need other components to be matched, has simple structure and low equipment cost. The design of the invention only needs the transmission mechanism for transmission, and the transmission mechanism is connected with the external driving mechanism when in use without other transmission components, thereby reducing the requirements on the equipment structure and being beneficial to management and operation. The invention adopts the sealing design of the box body, can well avoid the infectivity of the sample and the cross contamination in the detection process, and greatly improves the safety and the reliability of the detection.
The extraction part comprises an extraction column and an extraction sliding part, the extraction sliding part is movably connected to the extraction guide rail and can move along the extraction guide rail under the transmission action of the transmission mechanism, and the extraction sliding part drives the extraction column to move when moving, so that the extraction column can enter and exit each processing chamber.
The invention provides a liquid suction component which comprises a liquid suction sliding part and a liquid suction assembly, wherein the liquid suction sliding part is movably connected with a liquid suction guide rail and can move along the liquid suction guide rail under the transmission action of a transmission mechanism, and the liquid suction assembly moves along with the liquid suction sliding part to realize the entrance and exit of each processing chamber.
The invention is provided with a liquid suction assembly which comprises a liquid suction head, a liquid suction guide pipe and a liquid suction driving piece, wherein the liquid suction head is connected with the liquid suction sliding piece and is driven by a transmission mechanism to move in the horizontal direction, and the liquid suction head also moves up and down under the limiting action of a liquid suction guide rail, so that the liquid suction head can further enter and exit each processing chamber. The imbibition driving piece sets up just pass through in the box imbibition pipe intercommunication the imbibition head, the imbibition driving piece passes through the imbibition guide rail and realizes that the imbibition head absorbs and spits out the solution of corresponding function, realizes the transfer of different solutions and mixes in order to realize corresponding function.
The liquid suction driving part comprises a pneumatic liquid suction pump, the elastic part and a plug, and the air in the cavity of the liquid suction pump can be compressed and released through the deformation of the elastic part under the action of external force, so that the liquid suction head can respectively suck and discharge solutions with corresponding functions. When the pneumatic plug is used, the plug can be moved only by connecting the starting liquid suction pump with an external driving piece.
The sample-adding hole cover is disposable, and is designed with the inverted structure, the sample-adding hole cover cannot be taken out after being arranged at the position of the channel opening of the sample-adding channel, so that the use safety of the multifunctional device for sample processing and detection is improved, and meanwhile, the inverted structure can realize the sealing fit of the shell and the base.
Drawings
FIG. 1 is an angle view of a sample processing and testing multifunctional device according to an embodiment of the present invention;
FIG. 2 is a schematic view of another embodiment of a sample processing and detecting multifunctional device;
FIG. 3 is a schematic side view of a sample processing and testing multifunctional device according to an embodiment of the invention;
FIG. 4 is a schematic side cross-sectional view of a sample processing and detection multifunction device according to an embodiment of the invention;
FIG. 5 is a schematic view of an extraction slide of a multi-functional sample processing and testing device according to an embodiment of the present invention;
FIG. 6 is a schematic view of a liquid-absorbing sliding member of the multifunctional apparatus for sample processing and detection according to an embodiment of the present invention;
FIG. 7 is a schematic view of an extraction column of the multifunctional apparatus for sample processing and detection according to an embodiment of the present invention;
FIG. 8 is a schematic view of a pipetting assembly of the multifunctional apparatus for sample processing and detection according to an embodiment of the present invention;
FIG. 9 is a schematic view of a pipetting driver of a multifunctional apparatus for sample processing and detection according to an embodiment of the present invention;
FIG. 10 is a schematic view of a transmission mechanism of a multifunctional device for sample processing and detection according to an embodiment of the present invention.
Description of the reference numerals
10. A sample processing and detection multifunction device; 100. a box body; 110. a processing chamber; 120. a base; 130. a housing; 131. a sample application hole; 140. a sample hole cover; 200. an extraction mechanism; 210. extracting a guide track; 211. a first circuitous structure; 220. an extraction component; 221. an extraction column; 2211. extracting the magnetic rod; 2212. extracting the connecting rod; 222. extracting the sliding part; 300. a liquid suction mechanism; 310. a fluid-suction guide rail; 311. a second circuitous structure; 320. a liquid absorbing member; 321. a wicking assembly; 3211. a liquid suction head; 3212. a liquid suction conduit; 3213. a fluid-absorbent driving member; 32131. a pneumatic liquid suction pump; 32132. an elastic member; 32133. a plug; 322. a liquid suction slider; 400. and a transmission mechanism.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
In the description of the present invention, it should be understood that the terms used in the present invention are used in the description of the present invention, and it should be understood that the directions or positional relationships indicated by the terms "center", "upper", "lower", "bottom", "inner", "outer", etc. in the present invention are based on the directions or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
It should be understood that the terms "first", "second", etc. are used herein to describe various information, but the information should not be limited to these terms, which are only used to distinguish one type of information from another. For example, "first" information may also be referred to as "second" information, and similarly, "second" information may also be referred to as "first" information, without departing from the scope of the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening elements, or they may be in communication within two elements, i.e., when an element is referred to as being "secured to" another element, it may be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1 and 2 together, one embodiment of the present invention provides a sample processing and testing multifunctional device 10.
A sample processing and detecting multifunctional device 10 comprises a box 100, an extracting mechanism 200, a liquid suction mechanism 300 and a transmission mechanism 400.
Referring to fig. 1 and 2, the shape and structure of the box 100 may be a rectangular parallelepiped structure, and the corners of the box 100 are rounded. It is understood that in other embodiments, the structure and shape of the case 100 are not limited to the above, and the structure and shape of the case 100 may also be a polygonal column, a cylinder, an elliptical column, or other structures.
Referring to fig. 3 and 4, a plurality of processing chambers 110 and a sample loading channel for loading samples are disposed in the box 100. In one specific example, the plurality of process chambers 110 are sequentially distributed along the driving direction of the driving mechanism 400.
Referring to fig. 4, the extracting mechanism 200 includes an extracting guide rail 210 and an extracting member 220. The extraction guide rail 210 is disposed on the inner sidewall of the casing 100 and above the processing chambers 110, and a portion of the extraction guide rail 210 is in a first winding structure 211, wherein a winding distance of the first winding structure 211 is equal to a width of one processing chamber 110, the extraction member 220 is movably connected to the extraction guide rail 210, and the extraction member 220 is further connected to the transmission mechanism 400.
Referring to fig. 4, the suction mechanism 300 includes a suction guide rail 310 and a suction member 320. The imbibition guide rail 310 is arranged on the inner side wall of the box 100 and above the processing chambers 110, a part of the imbibition guide rail 310 is in a second circuitous structure 311, wherein, the once circuitous distance in the first circuitous structure 211 is equal to the width of one processing chamber 110, the imbibition member 320 is movably connected with the imbibition guide rail 310, the imbibition member 320 is further connected with the transmission mechanism 400, and the imbibition member 320 is further communicated with the sample feeding channel.
The transmission mechanism 400 is used for connecting with an external driving mechanism. The external driving mechanism can be a driving motor, a driving cylinder and the like.
In one specific example, the extraction member 220 includes an extraction column 221 and an extraction slider 222. Referring to fig. 5, the extracting sliding member 222 is movably connected to the extracting guide rail 210 and connected to the transmission mechanism 400, and the extracting column 221 is connected to the extracting sliding member 222. The extraction component 220 comprises an extraction column 221 and an extraction sliding piece 222, the extraction sliding piece 222 is movably connected to the extraction guide rail 210 and can move along the extraction guide rail 210 under the transmission action of the transmission mechanism 400, and the extraction sliding piece 222 drives the extraction column 221 to move when moving, so that the extraction column 221 enters or exits each processing chamber 110.
In one specific example, referring to fig. 7, the extraction column 221 includes an extraction bar magnet 2211 and an extraction connecting rod 2212. The extraction bar magnet 2211 is connected to the extraction slide 222 through an extraction connecting rod 2212 for extracting nucleic acids from within the processing chamber 110.
In one particular example, the wicking component 320 includes a wicking slide 322 and a wicking assembly 321. Referring to fig. 6, the suction slide member 322 is movably connected to the suction guide rail 310 and connected to the driving mechanism 400, and the suction assembly 321 is connected to the suction slide member 322. The invention provides that the liquid absorbing component 320 comprises a liquid absorbing sliding component 322 and a liquid absorbing component 321, the liquid absorbing sliding component 322 is movably connected with the liquid absorbing guide track 310 and can move along the liquid absorbing guide track 310 under the driving action of the driving mechanism 400, and the liquid absorbing component 321 moves along with the liquid absorbing sliding component 322 to realize the access to each processing chamber 110.
In one embodiment, as shown in fig. 8, the suction assembly 321 includes a suction head 3211, a suction conduit 3212, and a suction actuator 3213. The pipette head 3211 is connected to the pipette slider 322 for pipetting from the processing chamber 110, the pipette driver 3213 is provided in the casing 100 and communicates with the pipette head 3211 through a pipette guide 3212, and the sample application channel communicates with the pipette guide 3212. The liquid suction assembly 321 comprises a liquid suction head 3211, a liquid suction guide pipe 3212 and a liquid suction driving member 3213, the liquid suction head 3211 is connected to the liquid suction sliding member 322 and is driven by the transmission mechanism 400 to move in the horizontal direction, and the liquid suction head 3211 moves up and down under the limiting action of the liquid suction guide rail 310, so as to further realize the entrance and exit of each processing chamber 110. Imbibition driving piece 3213 sets up in box 100 and through imbibition pipe 3212 intercommunication imbibition head 3211, and imbibition driving piece 3213 realizes imbibition head 3211 through the imbibition guide rail and absorbs and spit out the solution of corresponding function, realizes the transfer and the mixture of different solutions in order to realize corresponding function.
In one particular example, the dip tube 3212 is a hose. The embodiment provides the pipette 3212 as a hose to facilitate the movement of the pipette head 3211.
In one embodiment, as shown in fig. 9, the fluid-absorbing driving member 3213 includes a pneumatic fluid-absorbing pump 32131, an elastic member 32132, and a stopper 32133. The pneumatic imbibition pump 32131 has a imbibition pump cavity, a first pneumatic interface communicated with the imbibition pump cavity and used for externally connecting a driving member, and a second pneumatic interface communicated with the imbibition guide pipe 3212, the elastic member 32132 is arranged in the imbibition pump cavity, the plug 32133 is movably arranged in the imbibition pump cavity and is in sealing fit with the inner wall of the imbibition pump cavity, and the sample adding channel is communicated with the imbibition pump cavity. The invention is provided with a liquid suction driving piece 3213 which comprises a pneumatic liquid suction pump 32131, an elastic piece 32132 and a plug 32133, and the elastic piece 32132 can deform under the action of external force to compress and release air in the cavity of the liquid suction pump, so as to achieve the purpose that the liquid suction head 3211 sucks and discharges the solution with corresponding functions respectively. When the pneumatic plug 32133 moving device is used, the plug 32133 can be moved only by connecting the driving piece externally connected with the liquid suction pump, the pneumatic plug 32133 moving device has no requirement on an externally connected air cylinder, and only the piston movement of the plug 32133 can be realized pneumatically.
Referring to fig. 10, in one specific example, the transmission mechanism 400 is a transmission screw. The extracting member 220 is screw-coupled to the driving mechanism, and the liquid sucking member 320 is screw-coupled to the driving mechanism 400.
In one particular example, the case 100 includes a base 120 and a housing 130. The base 120 is provided with a processing chamber 110, the housing 130 covers the base 120 and is hermetically connected with the base 120, and the housing 130 is provided with a sample adding channel.
In one specific example, the casing 100 is further provided with a sample port cover 140. The orifice cover 140 covers the outward-facing opening of the sample addition channel to seal the opening.
In one embodiment, referring to fig. 3, the inner surface of the sample-adding hole cover 140 has an inverted structure, and when the sample-adding hole cover 140 is covered on the outward channel opening of the sample-adding channel, the inverted structure is buckled on the inner wall of the channel opening. The sample-adding hole cover 140 is disposable, and is designed with a reverse-buckling structure, so that the sample-adding hole cover 140 cannot be taken out after being positioned at the channel opening of the sample-adding channel, the safety of the multifunctional device 10 for sample processing and detection is improved, and meanwhile, the shell 130 can be connected with the base 120 through the reverse-buckling structure to realize sealing fit.
In one specific example, at least one side of the base 120 has an upwardly protruding support arm, the top of the support arm has a sample application channel, the housing 130 has a sample application hole 131, the housing 130 is covered behind the base 120, the sample application hole 131 is communicated with the sample application channel, and the upside-down structure of the sample application hole cover 140 is covered behind the sample application hole 131 can realize the connection between the housing 130 and the support arm.
In one embodiment, referring to fig. 4, the first winding structure 211 and the second winding structure 311 are both disposed above the processing chamber 110, and/or the first winding structure 211 and the second winding structure 311 are disposed in a staggered manner.
Further, the first winding structure 211 and the second winding structure 311 may be respectively formed on the inner wall of the housing 130 in a concave manner.
In the present invention, a plurality of isolated processing chambers 110 are disposed in the box 100, each processing chamber 110 is used for storing a solution with a corresponding function and participating in a reaction, and the transfer and the reaction of the corresponding solution are realized under the cooperation of different components such as the extraction mechanism 200 and the liquid suction mechanism 300. The extracting component 220 of the extracting mechanism 200 can move along the transmission mechanism 400 and the extracting guide rail 210 according to a preset rail under the transmission action of the transmission mechanism 400, and the extracting component 220 can horizontally move through the transmission action of the transmission mechanism 400 on one hand and can vertically reciprocate under the limiting action of the first circuitous structure 211 of the extracting guide rail 210 on the other hand so as to complete corresponding functions. Similarly, the liquid suction component 320 of the liquid suction mechanism 300 moves along the transmission mechanism 400 and the liquid suction guide rail 310 according to the preset rail under the transmission action of the transmission mechanism 400, and on one hand, the liquid suction component 320 horizontally moves through the transmission action of the transmission mechanism 400, and on the other hand, the liquid suction component 320 also vertically reciprocates under the limitation action of the second circuitous structure 311 of the liquid suction guide rail 310, so as to complete the corresponding function. The transmission mechanism 400 is connected with an external driving mechanism to realize horizontal transmission of the extraction component 220 and the liquid suction component 320 so as to complete the movement of the extraction component 220 and the liquid suction component 320 according to a preset track. The invention simplifies each component, increases the transfer matching of each internal component such as the extraction component 220 and the imbibing component 320, creatively guides the extraction component 220 to move up and down through the circuitous structure of the extraction guide rail 210, guides the imbibing component 320 to move up and down through the circuitous structure of the imbibing guide rail 310, does not need other components to match, has simple structure and low equipment cost. The design of the invention only needs the transmission mechanism 400 for transmission, and the transmission mechanism 400 is connected with the external driving mechanism when in use without other transmission components, thereby reducing the requirements on the equipment structure and being beneficial to management and operation. The invention adopts the sealing design of the box body 100, can well avoid the infectivity of the sample and the cross contamination in the detection process, and greatly improves the safety and the reliability of the detection.
In summary, the multifunctional device 10 for sample processing and detection of the present invention can avoid the risk of sample infection and cross contamination during the detection process, and greatly improve the safety and reliability of sample detection. The sample processing and testing multifunctional device 10 of the present invention.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. A sample processing and detecting multifunctional device is characterized by comprising a box body, an extracting mechanism, a liquid absorbing mechanism and a transmission mechanism;
a plurality of mutually isolated processing chambers and a sample adding channel for adding samples are arranged in the box body;
the extraction mechanism comprises an extraction guide rail and an extraction part, the extraction guide rail is arranged on the inner side wall of the box body and is positioned above the processing chamber, part of the extraction guide rail is in a first circuitous structure, the extraction part is movably connected with the extraction guide rail, and the extraction part is also connected with the transmission mechanism;
imbibition mechanism includes imbibition guide rail and imbibition part, imbibition guide rail sets up the inside wall of box just is located the top of processing chamber, imbibition guide rail part position is the circuitous structure of second, imbibition part swing joint in imbibition guide rail, imbibition part still with drive mechanism connects, imbibition part still with the application of sample passageway communicates with each other.
2. The multi-functional apparatus for sample processing and testing as claimed in claim 1, wherein the extraction member comprises an extraction column and an extraction slider, the extraction slider is movably connected to the extraction guide rail and connected to the transmission mechanism, and the extraction column is connected to the extraction slider.
3. The multi-functional sample processing and detection device of claim 2, wherein the extraction column comprises an extraction magnetic rod and an extraction connecting rod, the extraction magnetic rod being connected to the extraction slide through the extraction connecting rod for extracting nucleic acids from within the processing chamber.
4. The multifunctional sample processing and detecting device according to any one of claims 1 to 3, wherein the liquid absorbing component comprises a liquid absorbing sliding component and a liquid absorbing assembly, the liquid absorbing sliding component is movably connected to the liquid absorbing guide rail and is connected with the transmission mechanism, and the liquid absorbing assembly is connected with the liquid absorbing sliding component.
5. The multifunctional sample processing and detecting device as claimed in claim 4, wherein the pipetting assembly comprises a pipetting head, a pipetting conduit and a pipetting driving member, the pipetting head is connected to the pipetting sliding member for pipetting from the processing chamber, the pipetting driving member is disposed in the case and is communicated with the pipetting head through the pipetting conduit, and the sample feeding channel is communicated with the pipetting conduit.
6. The multifunctional sample processing and detecting device according to claim 5, wherein the liquid suction driving member comprises a pneumatic liquid suction pump, an elastic member and a plug, the pneumatic liquid suction pump has a liquid suction pump cavity, a first pneumatic interface communicated with the liquid suction pump cavity and used for externally connecting the driving member, and a second pneumatic interface communicated with the liquid suction conduit, the elastic member is disposed in the liquid suction pump cavity, the plug is movably disposed in the liquid suction pump cavity and is in sealing fit with an inner wall of the liquid suction pump cavity, and the sample adding channel is communicated with the liquid suction pump cavity.
7. The multifunctional device for sample processing and detection as claimed in any one of claims 1 to 3 and 5 to 6, wherein the transmission mechanism is a transmission screw rod, the extraction member is in threaded connection with the transmission mechanism, and the liquid absorption member is in threaded connection with the transmission mechanism.
8. The multifunctional device for sample processing and detection according to any one of claims 1 to 3 and 5 to 6, wherein the case comprises a base and a housing, the base is provided with the processing chamber, the housing covers the base and is hermetically connected with the base, and the housing is provided with the sample adding channel;
and the box body is also provided with a sample adding hole cover which is used for sealing the sample adding channel.
9. The multifunctional sample processing and detecting device according to claim 8, wherein the inner surface of the sample-adding hole cover has an inverted structure, and when the sample-adding hole cover is disposed at the outward-facing channel opening of the sample-adding channel, the inverted structure is disposed on the inner wall of the channel opening;
at least one side of the base is provided with a supporting arm protruding upwards, the top of the supporting arm is provided with the sample adding channel, the shell is provided with a sample adding hole, the shell is covered and arranged behind the base, the sample adding hole is communicated with the sample adding channel, and the sample adding hole cover is arranged behind the sample adding hole, the inverted buckle structure can realize the connection between the shell and the supporting arm.
10. The multifunctional sample processing and detecting device according to any one of claims 1 to 3, 5 to 6 and 9, wherein a plurality of the processing chambers are sequentially distributed along the driving direction of the driving mechanism;
and/or the first bypass structure and the second bypass structure are both positioned above the processing chamber; the first circuitous structure and the second circuitous structure are arranged in a staggered mode.
CN202010934771.3A 2020-09-08 2020-09-08 Sample processing and detecting multifunctional device Pending CN111925935A (en)

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CN202010934771.3A CN111925935A (en) 2020-09-08 2020-09-08 Sample processing and detecting multifunctional device

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Application Number Priority Date Filing Date Title
CN202010934771.3A CN111925935A (en) 2020-09-08 2020-09-08 Sample processing and detecting multifunctional device

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CN202010934771.3A Pending CN111925935A (en) 2020-09-08 2020-09-08 Sample processing and detecting multifunctional device

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113173399A (en) * 2021-03-15 2021-07-27 北京戴纳实验科技有限公司 Transport case nucleic acid detecting system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113173399A (en) * 2021-03-15 2021-07-27 北京戴纳实验科技有限公司 Transport case nucleic acid detecting system

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