CN111905025B - 一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 - Google Patents
一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 Download PDFInfo
- Publication number
- CN111905025B CN111905025B CN202010958406.6A CN202010958406A CN111905025B CN 111905025 B CN111905025 B CN 111905025B CN 202010958406 A CN202010958406 A CN 202010958406A CN 111905025 B CN111905025 B CN 111905025B
- Authority
- CN
- China
- Prior art keywords
- parts
- crushed material
- traditional chinese
- chinese medicine
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用,属于口腔药物技术领域。以质量份数计,一种治疗口腔溃疡、止血镇痛消炎的中药组合物主要包括:1~10份的千里光提取物、1~10份的地骨皮提取物、1~10份的升麻提取物、1~10份的山银花提取物、1~10份的柴胡提取物、1~10份的蒲公英提取物、1~10份的延胡索提取物、1~10份的丙二醇和1~20份的纯化水;另一种治疗口腔溃疡、止血镇痛消炎的中药组合物主要包括1~10份的千里光粉碎物、1~10份的地骨皮粉碎物、1~10份的升麻粉碎物、1~10份的山银花粉碎物、1~10份的柴胡粉碎物、1~10份的蒲公英粉碎物、1~10份的延胡索粉碎物。本发明公开的治疗口腔溃疡、止血镇痛消炎的中药组合物,针对于口腔炎症和溃疡产生原因,优选中药,科学配伍,对预防和治疗口腔炎症、口腔溃疡等疾病,有效率高达99.0%,并具有有效修复口腔粘膜、显著止血镇痛消炎之功;具有选料天然来源,可生物降解,不易产生耐药性,且口感良好,对人体安全等特点。
Description
技术领域
本发明涉及一种用于治疗口腔溃疡、牙周炎、牙龈出血、冠周炎、牙龈肿痛,并具有止血镇痛消炎等功效的中药组合物及其制备方法与应用,属于口腔药物技术领域。
背景技术
口腔健康是全身健康的基础。如果把人的身体比作一棵大树,那口腔就相当于“大树的根须”。目前全国口腔患病率高达97.6%。
生活中大多数人都对口腔炎症不够重视,只知道牙痛要立即吃消炎药。其实口腔炎症是非常可怕的存在。“牙龈炎”是较轻的口腔炎症,初期表现为牙龈出血、牙龈红肿,龈乳头变圆钝肥大;牙龈炎如果未能及时治疗,炎症很可能会扩散到牙周,引发“牙周炎”,牙周炎的初期症状和牙龈炎差不多,但牙周炎慢慢恶化会形成牙周袋、牙周溢脓;牙周炎继续恶化,到最后牙槽骨发炎,进一步引发“牙髓炎”,疼痛难忍时,或许为时已晚了,将引发牙髓坏死,普通的消炎药和抗生素是毫无作用的;炎症继续扩散,细菌进入牙齿根尖周组织,就会引起“根尖周炎”,牙齿就可能保不住了。及早预防、及早制止口腔炎症的扩散才是最有效的处理方法。
而口腔炎症严重时,口腔粘膜容易被划伤,进一步引发口腔溃疡。口腔溃疡又称复发性阿弗他溃疡,是一种临床上常见的口腔粘膜疾病,据统计患病率达20%,在特定的人群中可高达66%,属口腔粘膜疾病之首,常好发于唇、颊、舌侧粘膜。口腔溃疡发作时疼痛剧烈,局部灼痛明显,严重者还会影响饮食、说话,对日常生活造成极大不便。
目前临床用于治疗口腔炎症、口腔溃疡的药物,大多采用一些成分较为单一的西药或中药,存在药效慢、有一定的毒副作用,会对胃肠等其他器官造成一定程度的伤害,易产生耐药性、且容易复发等问题。
因此开发出一款绿色安全、高效消炎镇痛止血的复方中药势在必行。
发明内容
为了克服上述现有技术存在的缺陷,本发明的目的在于提供一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用。
本发明是通过以下技术方案来实现:
一种治疗口腔溃疡、止血镇痛消炎的中药组合物,以质量份数计,包括1~10份的千里光提取物、1~10份的地骨皮提取物、1~10份的升麻提取物、1~10份的山银花提取物、1~10份的柴胡提取物、1~10份的蒲公英提取物、1~10份的延胡索提取物、1~10份的丙二醇和1~20份的纯化水。
所述的一种治疗口腔溃疡、止血镇痛消炎的中药组合物,以质量份数计,包括1~10份的千里光提取物、1~10份的地骨皮提取物、1~10份的升麻提取物、1~10份的山银花提取物、1~10份的柴胡提取物、1~10份的蒲公英提取物、1~10份的延胡索提取物、1~10份的丙二醇、1~20份的纯化水和1~10份飞龙掌血提取物、1~10份的一年蓬提取物、1~10份的清风藤提取物、1~10份的肿节风提取物、1~10份的青黛提取物、0.1~10份的蜂胶、0.1~10份的冰片中的一种或一种以上的组合物。
另一种治疗口腔溃疡、止血镇痛消炎的中药组合物,以质量份数计,包括1~10份的千里光粉碎物、1~10份的地骨皮粉碎物、1~10份的升麻粉碎物、1~10份的山银花粉碎物、1~10份的柴胡粉碎物、1~10份的蒲公英粉碎物、1~10份的延胡索粉碎物。
所述的另一种治疗口腔溃疡、止血镇痛消炎的中药组合物,包括1~10份的千里光粉碎物、1~10份的地骨皮粉碎物、1~10份的升麻粉碎物、1~10份的山银花粉碎物、1~10份的柴胡粉碎物、1~10份的蒲公英粉碎物、1~10份的延胡索粉碎物和1~10份的飞龙掌血粉碎物、1~10份的一年蓬粉碎物、1~10份的清风藤粉碎物、1~10份的肿节风粉碎物、1~10份的青黛粉碎物、0.1~10份的冰片粉碎物中的一种或一种以上的组合物。
所述的一种治疗口腔溃疡、止血镇痛消炎的中药组合物的制备方法,包括以下步骤:
(1)将各中药原料分别除杂、洗净,在40~60℃下烘干;
(2)将千里光、地骨皮、升麻、山银花、柴胡、延胡索、一年蓬、清风藤、肿节风、青黛分别用8~10倍量的纯化水浸泡24h,然后在40~50℃下萃取6h,过滤,滤渣再用6~8倍量的水40~50℃下萃取6h,合并2次的滤液,将各中药的滤液分别在50℃左右浓缩至适当体积,即得各中药提取物;
(3)蒲公英和飞龙掌血用8~10倍量的30%~50%乙醇溶液浸泡24h后,然后在35~60℃下回流萃取6h,过滤,滤渣再用6~8倍量的30%~50%乙醇溶液35~60℃下回流回流萃取6h,合并两次的滤液,将各滤液在60℃左右浓缩除去乙醇,并浓缩至合适体积,即得蒲公英提取物和飞龙掌血提取物;
(4)蜂胶或冰片预先用丙二醇溶解完全,按比例称取适量的上述提取物,然后加入适量的丙二醇和纯化水,混合均匀后,即获得治疗口腔溃疡、止血镇痛消炎的中药组合物。
所述的另一种治疗口腔溃疡、止血镇痛消炎的中药组合物的制备方法,包括以下步骤:
(1)将各中药原料分别除杂、洗净,在40~60℃下烘干;
(2)将千里光、地骨皮、升麻、山银花、柴胡、蒲公英、延胡索、飞龙掌血、一年蓬、清风藤、肿节风、青黛、冰片分别超微粉碎过1000~1200目筛,得到各中药的粉碎物;
(3)按比例称取适量的上述粉碎物,混合均匀后,即获得治疗口腔溃疡、止血镇痛消炎的中药组合物。
所述的治疗口腔溃疡、止血镇痛消炎的中药组合物,该中药组合物添加药学或食品学上可接受的辅料在药品或口腔护理产品的应用。
所述的治疗口腔溃疡、止血镇痛消炎的中药组合物的应用,所述的中药组合物在药品或口腔护理产品中的使用量为该药品或口腔护理产品总重量的0.01%~99.9%。
所述的治疗口腔溃疡、止血镇痛消炎的中药组合物的应用,所述的药品或口腔护理产品包括但不限于牙膏、牙凝胶、含漱水、喷雾剂、散剂、乳膏、速崩漱口片、泡腾片或含片。
与现有技术相比,本发明提供的治疗口腔溃疡、止血镇痛消炎的中药组合物,具有以下优势:
1、本发明提供的治疗口腔溃疡、止血镇痛消炎的中药组合物,从口腔炎症和溃疡产生机理着手,优选包括千里光、地骨皮、升麻、山银花、柴胡、蒲公英、延胡索等中药,其中千里光清热解毒,治疗各种急性炎症;地骨皮凉血除蒸,可止齿血、缓解口腔糜烂症状;升麻清热解毒,缓解因胃火亢盛的牙龈浮烂、口舌生疮剂咽喉肿痛;山银花清热解毒、凉散风热,抗炎、解热、缓解牙龈肿痛、去除皮肤疮热毒、湿毒等;柴胡和解表里,疏肝,升阳,具有解热、镇静镇痛、抗炎作用,缓解口舌糜烂;蒲公英清热解毒、抗菌消炎、消肿止痛,减轻溃疡面肿胀,缓解口腔溃疡疼痛;延胡索活血散瘀、行气止痛、有镇静镇痛之功;各活性成分科学配伍,协同增效。
2、本发明提供的治疗口腔溃疡、止血镇痛消炎的中药组合物,作为止血镇痛消炎剂,可广泛应用于口腔护理类产品及口腔药物,可有效预防和治疗口腔炎症及口腔溃疡,对口腔炎症和口腔溃疡的治愈率达到99.0%以上。
3、本发明提供的治疗口腔溃疡、止血镇痛消炎的中药组合物,选料天然来源,可生物降解,无药物残留,不易产生耐药性,对环境友好,安全高效,口感良好。
具体实施方式
实施例1~实施例4一种治疗口腔溃疡、止血镇痛消炎的中药组合物的制备
表1为实施例1~实施例4的一种治疗口腔溃疡、止血镇痛消炎的中药组合物的具体配方。
表1一种治疗口腔溃疡、止血镇痛消炎的中药组合物的具体配方
实施例1~实施例4中A1~A4的制备方法:
(1)将各中药清洗除杂后,在50℃下烘干;
(2)将千里光、地骨皮、升麻、山银花、柴胡、延胡索、一年蓬、清风藤、肿节风、青黛分别用10倍量的纯化水浸泡24h,然后在50℃下萃取6h,过滤,滤渣再用6倍量的水50℃下萃取6h,合并2次的滤液,将各中药的滤液分别在50℃左右浓缩至适当体积,即得各中药提取物;
(3)蒲公英和飞龙掌血用9倍量的40%乙醇溶液浸泡24h后,然后在55℃下回流萃取6h,过滤,滤渣再用7倍量的40%乙醇溶液55℃下回流萃取6h,合并两次的滤液,将各滤液在60℃左右浓缩除去乙醇,并浓缩至核实体积,即得蒲公英提取物和飞龙掌血提取物;
(4)将蜂胶或冰片预先用丙二醇溶解完全后,按配方A1~A4分别称取适当的提取物,然后加入适量的丙二醇和纯化水,混合均匀后,即获得治疗口腔溃疡、止血镇痛消炎的中药组合物A1~A4。
实施例5~8另一种治疗口腔溃疡、止血镇痛消炎的中药组合物的制备
表2另一种治疗口腔溃疡、止血镇痛消炎的中药组合物的具体配方
实施例5~8中A5~A8的制备方法:
(1)将各中药原料分别除杂、洗净,在60℃下烘干;
(2)将千里光、地骨皮、升麻、山银花、柴胡、蒲公英、延胡索、飞龙掌血、一年蓬、清风藤、肿节风、青黛、冰片分别超微粉碎过1000~1200目筛,得到各中药的粉碎物;
(3)按比例称取适量的上述粉碎物,混合均匀后,即获得治疗口腔溃疡、止血镇痛消炎的中药组合物A5~A8。
实施例9一种治疗口腔溃疡、止血镇痛消炎的中药组合物口腔喷雾剂的制备
中药组合物组成:实施例1中A1配方
制备方法:将0.15份EDTA-2Na和3份YouthVigor+(促进细胞新陈代谢、修复屏障)加入68.32份纯化水中,搅拌至完全溶解,加入预先混合好的2.5份生物抑菌剂口舒肽(HOROraltide)、8份丙二醇和3份PEG-7,混合均匀后,再依次加入15份治疗口腔溃疡、止血镇痛消炎的中药组合物A1和预先用1份酒精溶解好的0.03份薄荷脑,混合均匀后,然后用柠檬酸调节pH至5.0左右,即制备得到治疗口腔溃疡、止血镇痛消炎的中药组合物喷雾剂。
实施例10~实施例11一种含治疗口腔溃疡、止血镇痛消炎的中药组合物的含漱水的制备
表3含治疗口腔溃疡、止血镇痛消炎的中药组合物的含漱水配方
含治疗口腔溃疡、止血镇痛消炎的中药组合物含漱水的制备方法:
(1)按表3中应用实施例10、11和对比例1的含漱水的配方组成,将A相各组分搅拌溶解完全;
(2)将B相各组分混合溶解完全,并加入到A相并同时搅拌混合均匀;
(3)然后依次加入C、D相组分混合均匀;
(4)再加入E相中,搅拌混合均匀后,出料。即得到镇痛消炎含漱水I、镇痛消炎含漱水II和基础含漱水1。
实施例12一种含治疗口腔溃疡、止血镇痛消炎的中药组合物的泡腾片的制备
中药组合物组成:实施例4中A4配方
制备方法:将中药组合物A4 5份加入柠檬精油2.5份、薄荷精油2.5份、迷迭香精油2份、丁香籽油0.5份、茶树精油0.5份,碳酸氢钠2份、柠檬酸9份、十二烷基磺酸钠0.4份、硫酸钙0.2份、聚乙烯吡咯烷酮16份、木糖醇0.8份和硬脂酸钠0.5份混合均匀,用无水乙醇造粒,在80℃下干燥挥发除去乙醇,最后加入硬脂酸钠1份,压片,即得具有治疗口腔溃疡、止血镇痛消炎功效的口腔泡腾片。
实施例13一种含治疗口腔溃疡、止血镇痛消炎的中药组合物散剂的制备
组合物的组成:实施例5中A8配方。
制备方法:混合均匀的治疗口腔溃疡、止血镇痛消炎的中药组合物A8,即为含治疗口腔溃疡、止血镇痛消炎的中药组合物散剂。
实施例14一种含治疗口腔溃疡、止血镇痛消炎的中药组合物牙膏的制备
组合物组成:实施例3中A3配方
制备方法:先将1份香精、4份糖精钠用25份纯化水溶解完全,然后加入制膏锅中,再加入5份的山梨醇,搅拌溶解后,再依次加入35份碳酸钙、5份CMC、3份K12、5份二氧化硅,依次经刮板搅拌、均质搅拌、研磨;并抽真空,然后加入8份A3、2份口舒肽,充分混合均匀,研磨使膏体细腻,陈化120min,罐装,即制得具有治疗口腔溃疡、止血镇痛消炎的中药组合物牙膏
以下通过具体实验例来说明含治疗口腔溃疡、止血镇痛消炎的中药组合物的有益效果。
测试材料:实施例9中含治疗口腔溃疡、止血镇痛消炎的中药组合物的喷雾剂
测试对象:选取100名受试者参加试验,受试者均为符合纳入及排除标准的健康的成年男性和女性,其中男性65例,女性35例,有患牙龈炎25例、牙龈炎伴牙龈出血肿痛25例、牙周炎伴出血肿痛18例、口腔溃疡26例,四者并存6例,均无其他疾病(呼吸道、血液及胃肠道疾病)。
测试方法:受试者餐后用清水漱口后,在患处喷洒喷雾剂,每次3-5ml,在口腔中保留5min,再吞服;每日3-4次,连续使用一周后评价使用效果。
疗效判断标准:显效:使用后牙龈牙周充血水肿明显减轻或消失,医用棉签触碰不同,牙龈出血停止,溃疡创面减少50%以上或痊愈;好转:使用后牙龈出血停止,充血水肿轻微,医用棉签触碰轻痛,有少许渗血,溃疡创面有所减少,但低于50%;无效:使用后牙龈出血、疼痛及口腔溃疡无明显改善。
表4效果测试
由表4可知,临床100名受试者观察结果显示:实施例9可显著改善牙龈炎、牙龈炎伴牙龈出血肿痛、牙周炎伴出血肿痛、口腔溃疡的症状;对于口腔粘膜类(急性感染性口炎、复发性口腔溃疡、急性多发性牙龈囊肿)总有效率从达到99.0%;对牙龈炎有效率达到100%,对牙周炎有效率达100%,对牙囊肿、牙龈出血、口臭的有效率达99.0%。由此可见,本发明的提供的治疗口腔溃疡、止血镇痛消炎中药组合物对口腔炎症、口腔溃疡具有很显著的疗效。
典型应用案例
王某,男性,40岁,口腔粘膜反复出现点片状溃疡4年,每年发作3-5个月,每次均服用西药可暂愈,但频繁复发。本次口腔溃疡3天后,停服所有口服药物,用实施例9的口腔喷雾剂,每次用5ml,每日5~6次。次日疼痛减轻,4日后痊愈。以后又发作2次,均采用本法治愈。后每天饭后采用含实施例11含漱水含漱5min,直至现在均未见复发。
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明,不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干简单推演或替换,都应当视为属于本发明的保护范围。
Claims (4)
1.一种治疗口腔溃疡、止血镇痛消炎的中药组合物,其特征在于,以质量份数计,由5份的千里光粉碎物、5份的地骨皮粉碎物、4份的升麻粉碎物、5份的山银花粉碎物、5份的柴胡粉碎物、5份的蒲公英粉碎物、5份的延胡索粉碎物制成。
2.根据权利要求1所述的一种治疗口腔溃疡、止血镇痛消炎的中药组合物的制备方法,其特征在于包括以下步骤:
(1)将各中药原料分别除杂、洗净,在40~60℃下烘干;
(2)将千里光、地骨皮、升麻、山银花、柴胡、蒲公英、延胡索分别超微粉碎过1000~1200目筛,得到各中药的粉碎物;
(3)按比例称取适量的上述粉碎物,混合均匀后,即获得治疗口腔溃疡、止血镇痛消炎的中药组合物。
3.根据权利要求1所述的治疗口腔溃疡、止血镇痛消炎的中药组合物在制备药品或口腔护理产品中的应用,其特征在于该中药组合物添加药学上可接受的辅料。
4.根据权利要求3所述的治疗口腔溃疡、止血镇痛消炎的中药组合物的应用,其特征在于,所述的药品或口腔护理产品为牙膏、牙凝胶、含漱水、喷雾剂、散剂、乳膏、速崩漱口片、泡腾片或含片。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010958406.6A CN111905025B (zh) | 2020-09-14 | 2020-09-14 | 一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010958406.6A CN111905025B (zh) | 2020-09-14 | 2020-09-14 | 一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111905025A CN111905025A (zh) | 2020-11-10 |
CN111905025B true CN111905025B (zh) | 2022-04-01 |
Family
ID=73266980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010958406.6A Active CN111905025B (zh) | 2020-09-14 | 2020-09-14 | 一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111905025B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1504215A (zh) * | 2002-11-29 | 2004-06-16 | 贵阳新天药业股份有限公司 | 一种治疗口腔疾病的中药制剂及制备方法 |
CN102000209A (zh) * | 2010-11-19 | 2011-04-06 | 贵阳新天药业股份有限公司 | 一种龙掌口含液的质量检测方法 |
-
2020
- 2020-09-14 CN CN202010958406.6A patent/CN111905025B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1504215A (zh) * | 2002-11-29 | 2004-06-16 | 贵阳新天药业股份有限公司 | 一种治疗口腔疾病的中药制剂及制备方法 |
CN102000209A (zh) * | 2010-11-19 | 2011-04-06 | 贵阳新天药业股份有限公司 | 一种龙掌口含液的质量检测方法 |
Non-Patent Citations (1)
Title |
---|
补中益气汤治愈复发性口疮1例;马瑞荣;《中国中医急症》;20061228;第15卷(第12期);1353 * |
Also Published As
Publication number | Publication date |
---|---|
CN111905025A (zh) | 2020-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101574445B (zh) | 一种具有口腔保健功效的中药组合物 | |
CN103520049B (zh) | 复方中药提取物在制备口腔护理保健品中的应用 | |
CN112022920A (zh) | 一种中药牙粉及其制备方法和应用 | |
CN111281836A (zh) | 一种纯中草药制备的多方面护齿牙粉及其制作方法 | |
CN1234342C (zh) | 中药牙膏 | |
CN102228417A (zh) | 含有薁磺酸钠的中草药牙膏组合物 | |
CN106511161A (zh) | 一种对口腔溃疡有治疗功效的中草药牙膏 | |
CN101007088A (zh) | 一种治疗牙周疾病的中药组合物及其制备方法 | |
CN104983806A (zh) | 一种治疗口腔疾病的中药组合物、制备方法及其应用 | |
CN110787078A (zh) | 一种含有甘草黄酮的牙膏及其制备方法和应用 | |
CN101199615B (zh) | 一种治疗口腔溃疡的外用内服口腔崩解片及其制备方法 | |
CN111905025B (zh) | 一种治疗口腔溃疡、止血镇痛消炎的中药组合物及其制备方法与应用 | |
US11806376B2 (en) | Pharmaceutical composition for treating oral ulcer and preparation method and application thereof | |
RU2319499C1 (ru) | Лекарственный сбор для лечения и профилактики заболевания пародонта, осложненного аллергическим состоянием | |
Mahant et al. | Home remedies for dental diseases in the Pandemic of COVID-19-A Systematic Review | |
Salma et al. | Triphala: The mystical herb and its role in dentistry | |
CN111743838A (zh) | 一种中药漱口水及其制备方法 | |
CN104258092A (zh) | 一种治疗复发性口疮和牙周病的含漱液及其制备方法 | |
CN111329903B (zh) | 一种中药组合物及其应用 | |
CN102895505B (zh) | 一种治疗龋齿牙痛的药物 | |
CN110859790B (zh) | 中药组合物在制备口腔护理用品中的应用 | |
CN105560893A (zh) | 一种治疗牙周炎的中药组合物 | |
Deshmukh et al. | OVERVIRW ON MOUTH ULCER AND THEIR TREATMENT WITH HERBS | |
CN117414400A (zh) | 预防和治疗口腔溃疡的复方中药提取物及其制备方法和应用 | |
CN112089659A (zh) | 一种复方中药牙膏及其中药提取物的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |