CN111904981A - Production method of variola pox virus inflammation-causing rabbit fur - Google Patents
Production method of variola pox virus inflammation-causing rabbit fur Download PDFInfo
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- CN111904981A CN111904981A CN202010926886.8A CN202010926886A CN111904981A CN 111904981 A CN111904981 A CN 111904981A CN 202010926886 A CN202010926886 A CN 202010926886A CN 111904981 A CN111904981 A CN 111904981A
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- 241000283973 Oryctolagus cuniculus Species 0.000 title claims abstract description 119
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 28
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 26
- 208000001203 Smallpox Diseases 0.000 title claims description 17
- 241000870995 Variola Species 0.000 title claims description 17
- 241000700605 Viruses Species 0.000 title claims description 5
- 238000007710 freezing Methods 0.000 claims abstract description 18
- 230000008014 freezing Effects 0.000 claims abstract description 18
- 239000000427 antigen Substances 0.000 claims abstract description 10
- 102000036639 antigens Human genes 0.000 claims abstract description 10
- 108091007433 antigens Proteins 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 8
- 210000002268 wool Anatomy 0.000 claims abstract description 8
- 238000010008 shearing Methods 0.000 claims abstract description 6
- 210000005069 ears Anatomy 0.000 claims description 15
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 12
- 206010000496 acne Diseases 0.000 claims description 12
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000009461 vacuum packaging Methods 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 206010030113 Oedema Diseases 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 230000002159 abnormal effect Effects 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 230000037308 hair color Effects 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 230000003340 mental effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 abstract description 4
- 208000008035 Back Pain Diseases 0.000 abstract description 3
- 208000008930 Low Back Pain Diseases 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 208000004296 neuralgia Diseases 0.000 abstract description 3
- 230000002093 peripheral effect Effects 0.000 abstract description 3
- 208000011580 syndromic disease Diseases 0.000 abstract description 3
- 241000700618 Vaccinia virus Species 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000007089 vaccinia Diseases 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 201000003740 cowpox Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940076321 rabbit skin extract Drugs 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Immunology (AREA)
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- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a production method of inflammation-causing rabbit fur of vaccinia virus, which comprises the following steps of A, selecting inflammation-causing rabbits meeting the requirement of producing extracts; B. feeding, observing and producing the wool, and shearing the wool; C. injecting diluted antigen and observing and feeding; D. rapidly freezing rabbit skin; E. processing the peeled rabbit dead body; F. the rabbit fur of the inflammation-causing rabbit can be quickly collected, the demand pressure of the market on the rabbit fur of the inflammation-causing rabbit is relieved, the rabbit fur of the inflammation-causing rabbit can be used for extracting medicine components with biological analgesic effect for treating various peripheral neuralgia such as shoulder-neck-wrist syndrome, lumbago and the like, the demand of the current market on the medicine components is increased year by year, but the yield of the rabbit fur for production and extraction is lower, and the invention aims to realize the professional production line production of the rabbit fur of the inflammation-causing rabbit step by step.
Description
Technical Field
The invention relates to the technical field of professional production of rabbit fur of inflammation-causing rabbits, in particular to a production method of rabbit fur causing inflammation by vaccinia virus.
Background
The injection of the vaccinia vaccine inflammation-causing rabbit skin extract is prepared by the exclusive production in China, has unique biological analgesic effect, used for treating various peripheral neuralgia such as shoulder, neck and wrist syndrome, lumbago and the like, and vaccinia vaccine inflammation-causing rabbit skin is a main raw material of an injection product, and also has pharmacological effects of regulating vegetative nerve disorder/maladjustment, improving peripheral circulation, regulating immunologic function, etc., compared with other classical analgesic and sedative drugs, has no obvious toxic and side effects, has good safety, because the curative effect is reliable and the toxic and side effect is small, the injection is gradually accepted by patients, the market share of the cowpox vaccine inflammation-causing rabbit fur extract injection is continuously increased, the traditional rabbit fur is adopted relatively slowly, the yield is difficult to ensure, therefore, how to realize professional stepwise production of rabbit fur of the inflammation-causing rabbits becomes a difficult problem which is urgently needed to be solved at present.
Disclosure of Invention
The invention aims to provide a method for producing inflammatory rabbit fur by professional assembly line production of the rabbit fur of inflammatory rabbits through professional step-by-step operation.
In order to achieve the purpose, the invention provides the following technical scheme: the production method of the variola pox virus inflammation-causing rabbit fur comprises the following specific operation steps:
A. selecting rabbits suitable for producing the extract to cause inflammation;
B. feeding, observing and producing the wool, and shearing the wool;
C. injecting diluted antigen and observing and feeding;
D. rapidly freezing rabbit skin;
E. processing the peeled rabbit dead body;
F. packaging and warehousing and freezing.
Preferably, according to the step A, the inflammation-causing rabbits which meet the requirements of producing the extract are selected:
a. selecting a unified variety of white rabbits;
b. roughly checking and removing white rabbits with hair color and poor mental appearance;
c. and uniformly numbering the screened white rabbits in batches.
Preferably, the production is standard and sheared according to step B feeding observation:
a. feeding and observing the screened white rabbits with big ears for 2-5 days to confirm no epidemic disease;
b. shaving the white rabbits with big ears according to the number of batches;
c. after shaving, the white rabbits with large ears were examined, and again, it was confirmed that the appearance was excellent and the white rabbits with poor appearance were removed.
Preferably, the diluted antigen is injected and observed for feeding according to step C:
a. injecting and diluting the antigen to the white rabbits in batches according to the number;
b. feeding and observing the performance condition of the white rabbits with big ears;
c. confirming that the white rabbits with big ears have obvious edema and acne, the total number of the acne is more than 100, the number of the acne with the diameter of more than 10mm is more than 80, and the color of the acne is red to purple red; tare weight 270 ± 30 g, tare thickness: the front, back, left and right are more than 2 mm, the skin is fresh, no peculiar smell exists, no injury is caused, and rabbit skin is reserved for taking.
Preferably, rabbit skin is snap frozen according to step D:
a. rapidly freezing and killing the white rabbits of the same batch at-18 ℃ in batches;
b. the killed big-ear white rabbits are transported to a sterile skin collecting workshop in batches;
c. and (4) checking the number of the collected rabbit skins with the number of the dead bodies of the rabbits.
Preferably, the peeled rabbit carcasses were treated according to step E:
a. numbering and recording the peeled rabbit corpses and carrying out vacuum packaging;
b. the number of the rabbit corpses which are packed in vacuum is recorded and is frozen and sealed;
c. and intensively destroying the dead rabbits accumulated to a certain number.
Preferably, the packaging is warehoused and subjected to freezing treatment according to step F:
a. carrying out batch number recording on the collected rabbit skin, and carrying out vacuum packaging;
b. after 24 hours, the mixture is transferred to-18 ℃ without any abnormal sample and is stored in a freezing way;
c. and checking the warehousing number, and storing the rabbit skins in the same batch in a unified area.
Compared with the prior art, the invention has the beneficial effects that:
(1) the method can realize the rapid completion of the rabbit fur collection of the inflammation-causing rabbits, relieve the pressure required by the market on the rabbit fur of the inflammation-causing rabbits, extract the medicinal components with the biological analgesic effect for treating various peripheral neuralgia such as shoulder-neck-wrist syndrome, lumbago and the like, and realize the professional production line production of the rabbit fur of the inflammation-causing rabbits through professional steps.
(2) Effectively utilize the high reproductive speed of rabbit, reduce the cost of extracting the raw materials, unify the serial number to rabbit fur and rabbit corpse, check quantity and serial number to this repeatedly, concentrate to destroy the rabbit corpse, avoid flowing into market, unify regional sealing up to the rabbit fur, be convenient for store and extract, carry out the sampling test to the sample, the problem appears in one example rabbit fur and is convenient for carry out whole batch, has guaranteed the quality of production.
Drawings
FIG. 1 is a schematic view of the flow structure of a specific production method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
As shown in figure 1, the specific operation method of the production method of the variola pox virus inflammation-causing rabbit fur comprises the following steps:
A. selecting rabbits suitable for producing the extract to cause inflammation;
B. feeding, observing and producing the wool, and shearing the wool;
C. injecting diluted antigen and observing and feeding;
D. rapidly freezing rabbit skin;
E. processing the peeled rabbit dead body;
F. packaging and warehousing and freezing.
Selecting the inflammation-causing rabbits meeting the production requirements according to the step A:
a. selecting a unified variety of white rabbits;
b. roughly checking and removing white rabbits with hair color and poor mental appearance;
c. and uniformly numbering the screened white rabbits in batches.
Feeding, observing and producing according with the standard according to the step B and shearing:
a. feeding and observing the screened white rabbits with big ears for 2-5 days to confirm no epidemic disease;
b. shaving the white rabbits with big ears according to the number of batches;
c. after shaving, the white rabbits with large ears were examined, and again, it was confirmed that the appearance was excellent and the white rabbits with poor appearance were removed.
Injecting diluted antigen and observing feeding according to step C:
a. injecting and diluting the antigen to the white rabbits in batches according to the number;
b. feeding and observing the performance condition of the white rabbits with big ears;
c. confirming that the white rabbits with big ears have obvious edema and acne, the total number of the acne is more than 100, the number of the acne with the diameter of more than 10mm is more than 80, and the color of the acne is red to purple red; tare weight 270 ± 30 g, tare thickness: the front, back, left and right are more than 2 mm, the skin is fresh, no peculiar smell exists, no injury is caused, and rabbit skin is reserved for taking.
And D, rapidly freezing and taking rabbit skins according to the step D:
a. rapidly freezing and killing the white rabbits of the same batch at-18 ℃ in batches;
b. the killed big-ear white rabbits are transported to a sterile skin collecting workshop in batches;
c. and (4) checking the number of the collected rabbit skins with the number of the dead bodies of the rabbits.
Processing the peeled rabbit carcass according to step E:
a. numbering and recording the peeled rabbit corpses and carrying out vacuum packaging;
b. the number of the rabbit corpses which are packed in vacuum is recorded and is frozen and sealed;
c. and intensively destroying the dead rabbits accumulated to a certain number.
And (5) packaging and warehousing according to the step F and performing freezing treatment:
a. carrying out batch number recording on the collected rabbit skin, and carrying out vacuum packaging;
b. after 24 hours, the mixture is transferred to-18 ℃ without any abnormal sample and is stored in a freezing way;
c. and checking the warehousing number, and storing the rabbit skins in the same batch in a unified area.
The above embodiments are only preferred embodiments of the present invention, and are not intended to limit the technical solutions of the present invention, so long as the technical solutions can be realized on the basis of the above embodiments without creative efforts, which should be considered to fall within the protection scope of the patent of the present invention.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A production method of variola pox virus inflammation-causing rabbit fur comprises the following steps:
selecting rabbits suitable for producing the extract to cause inflammation;
feeding, observing and producing the wool, and shearing the wool;
injecting diluted antigen and observing and feeding;
rapidly freezing rabbit skin;
processing the peeled rabbit dead body;
packaging and warehousing and freezing.
2. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: selecting the inflammation-causing rabbits meeting the production requirements according to the step A:
a. selecting a unified variety of white rabbits;
b. roughly checking and removing white rabbits with hair color and poor mental appearance;
c. and uniformly numbering the screened white rabbits in batches.
3. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: and B, feeding, observing and producing according to the step B, and shearing:
a. feeding and observing the screened white rabbits with big ears for 2-5 days to confirm no epidemic disease;
b. shaving the white rabbits with big ears according to the number of batches;
c. after shaving, the white rabbits with large ears were examined, and again, it was confirmed that the appearance was excellent and the white rabbits with poor appearance were removed.
4. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: injecting the diluted antigen and observing feeding according to the step C:
a. injecting and diluting the antigen to the white rabbits in batches according to the number;
b. feeding and observing the performance condition of the white rabbits with big ears;
c. confirming that the white rabbits with big ears have obvious edema and acne, the total number of the acne is more than 100, the number of the acne with the diameter of more than 10mm is more than 80, and the color of the acne is red to purple red; tare weight 270 ± 30 g, tare thickness: the front, back, left and right are more than 2 mm, the skin is fresh, no peculiar smell exists, no injury is caused, and rabbit skin is reserved for taking.
5. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: and D, rapidly freezing and taking rabbit skins according to the step D:
rapidly freezing and killing the white rabbits of the same batch at-18 ℃ in batches;
the killed big-ear white rabbits are transported to a sterile skin collecting workshop in batches;
c. and (4) checking the number of the collected rabbit skins with the number of the dead bodies of the rabbits.
6. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: and E, processing the peeled rabbit dead body according to the step E:
a. numbering and recording the peeled rabbit corpses and carrying out vacuum packaging;
b. the number of the rabbit corpses which are packed in vacuum is recorded and is frozen and sealed;
c. and intensively destroying the dead rabbits accumulated to a certain number.
7. The method for producing variola skin according to claim 1, wherein the variola skin is prepared by the following steps: and F, packaging and warehousing according to the step F and performing freezing treatment:
a. carrying out batch number recording on the collected rabbit skin, and carrying out vacuum packaging;
b. after 24 hours, the mixture is transferred to-18 ℃ without any abnormal sample and is stored in a freezing way;
c. and checking the warehousing number, and storing the rabbit skins in the same batch in a unified area.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010926886.8A CN111904981A (en) | 2020-09-07 | 2020-09-07 | Production method of variola pox virus inflammation-causing rabbit fur |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010926886.8A CN111904981A (en) | 2020-09-07 | 2020-09-07 | Production method of variola pox virus inflammation-causing rabbit fur |
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| CN202010926886.8A Pending CN111904981A (en) | 2020-09-07 | 2020-09-07 | Production method of variola pox virus inflammation-causing rabbit fur |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693914A (en) * | 2019-10-28 | 2020-01-17 | 威世药业（如皋）有限公司 | Application of vaccinia virus inflammation-causing rabbit skin extract in treatment of rheumatoid arthritis |
| CN115212235A (en) * | 2022-07-25 | 2022-10-21 | 威世药业（如皋）有限公司 | Production method of rabbit fur capable of causing inflammation by diluted vaccinia virus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137599A1 (en) * | 2001-03-08 | 2004-07-15 | Norman Spibey | Leporipox-based vector vaccines |
| US20060051375A1 (en) * | 2002-10-31 | 2006-03-09 | Cheung Wing S | Rabbit skin comprising biological active substances and its use |
| CN110693914A (en) * | 2019-10-28 | 2020-01-17 | 威世药业（如皋）有限公司 | Application of vaccinia virus inflammation-causing rabbit skin extract in treatment of rheumatoid arthritis |
-
2020
- 2020-09-07 CN CN202010926886.8A patent/CN111904981A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137599A1 (en) * | 2001-03-08 | 2004-07-15 | Norman Spibey | Leporipox-based vector vaccines |
| US20060051375A1 (en) * | 2002-10-31 | 2006-03-09 | Cheung Wing S | Rabbit skin comprising biological active substances and its use |
| CN110693914A (en) * | 2019-10-28 | 2020-01-17 | 威世药业（如皋）有限公司 | Application of vaccinia virus inflammation-causing rabbit skin extract in treatment of rheumatoid arthritis |
Non-Patent Citations (2)
| Title |
|---|
| 徐海栋;刘刚;赵建宁;许斌;: "牛痘疫苗致炎兔皮提取物注射液在腰椎管狭窄症术后应用临床疗效观察", 颈腰痛杂志, vol. 34, no. 02, pages 121 - 124 * |
| 李升;曾常爱;王政华;: "牛痘疫苗致炎兔皮提取物注射液治疗老年带状疱疹后遗神经痛", 中国老年学杂志, vol. 31, no. 17, pages 3284 - 3285 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693914A (en) * | 2019-10-28 | 2020-01-17 | 威世药业（如皋）有限公司 | Application of vaccinia virus inflammation-causing rabbit skin extract in treatment of rheumatoid arthritis |
| CN115212235A (en) * | 2022-07-25 | 2022-10-21 | 威世药业（如皋）有限公司 | Production method of rabbit fur capable of causing inflammation by diluted vaccinia virus |
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Application publication date: 20201110 |