CN111887934A

CN111887934A - Apparatus and method for aspiration of thrombus

Info

Publication number: CN111887934A
Application number: CN202010824341.6A
Authority: CN
Inventors: 李中华; 李天竹; 李敬; 马剑翔; 孟磊; 于博宇
Original assignee: Sino Medical Sciences Technology Inc
Current assignee: Sano Shenchang Medical Technology Co ltd
Priority date: 2020-08-17
Filing date: 2020-08-17
Publication date: 2020-11-06

Abstract

The invention relates to an apparatus and a method for aspirating thrombi, the apparatus comprising an aspiration catheter device, an aspiration assist wire and a negative pressure suction device, the aspiration catheter device comprising an aspiration catheter body, the negative pressure suction device being hermetically connected with the aspiration catheter body to provide negative pressure to the aspiration catheter body, the aspiration assist wire extending inside the aspiration catheter body, the aspiration assist wire being movable along the aspiration catheter body to dislodge thrombi. When the instrument for sucking thrombus is in the situation that the mouth of the suction catheter main body is blocked by larger and/or harder thrombus, the auxiliary suction wire can be used for slightly moving the thrombus blocked at the mouth of the suction catheter main body, so that the negative pressure acting on the suction catheter plays a role, the thrombus can quickly enter the suction catheter, and then the thrombus is sucked out of the human body, and the efficiency and the success rate of thrombus suction surgery are improved.

Description

Apparatus and method for aspiration of thrombus

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to an instrument for sucking thrombus and a method for sucking the thrombus by using the instrument.

Background

Stroke, commonly referred to as stroke, including ischemic stroke and hemorrhagic stroke, refers to the damage of cerebral vessels, focal or global brain tissue, resulting in clinical symptoms of over 24 hours or death due to various causes. At present, about 3000 million patients suffering from stroke worldwide exist, Chinese stroke patients reach more than 1200 million, ischemic stroke (AIS) accounts for about 75% -90% of all stroke, and hemorrhagic stroke only accounts for 10% -25%.

The key to AIS treatment is to open the occluded vessels and restore blood flow as early as possible to save the ischemic penumbra tissue. Current treatment protocols include interventional procedures (balloon angioplasty, stenting, mechanical embolectomy), surgical procedures (bypass of the intracranial external artery, endomembrane denudation), and drug therapies (thrombolysis, anticoagulant drugs).

The therapeutic method of the medicine is conservative, and the principle is that the thrombolytic medicine can dissolve thrombus in a diseased blood vessel, so that the purpose of recanalization of blood flow of the diseased blood vessel is achieved. However, thrombolytic regimens are severely time-limited, typically within 4.5 hours of stroke onset, and some drugs are usually delivered by systemic drug release, which increases the risk of systemic, including cerebral, hemorrhage, and therefore thrombolytic therapy is only suitable for treatment of a limited number of individuals.

Surgery, carotid endarterectomy is not a common treatment for stroke, and post-surgery can increase the risk of cerebral hemorrhage due to revascularization and vascular rupture of infarcted brain tissue.

The interventional operation is the most used treatment scheme at present, and two main types of interventional thrombus removal instruments are used at present, one type is a suction catheter, the design structure of the suction catheter is similar to a guide catheter, certain negative pressure is loaded at the tail end after the suction catheter reaches the proximal end of a blocked blood vessel, and free thrombus is sucked into the catheter or adsorbed at the catheter port and pulled out of the body, so that the blood flow at the pathological change part is recovered. The other is a thrombus taking support, the support thrombus taking equipment reaches intracranial arteries through an internal artery channel along arteries of lower limbs, then a thrombus blocking blood vessels is actively caught by a thrombus taking device at the front section of the catheter, certain negative pressure is applied to the tail end of the suction catheter, and the thrombus is taken out of a human body. The main advantage of mechanical embolectomy is that the treatment time window is increased and expanded to 4.5-10 hours after the onset of disease. However, the existing mechanical thrombus removal has some disadvantages, such as when the apparatus takes the thrombus out of the human body, some blood clots or particles may fall off from the process of retrieval, or the apparatus cannot completely take the thrombus out of the human body due to the complex condition of the thrombus, or the thrombus cannot be taken out of the human body at one time, and the thrombus needs to be repeatedly entered into a patient position to be removed, which undoubtedly brings greater risk to the patient.

Particularly, in the process of an aspiration and embolectomy, large and hard thrombus is often encountered, the opening of the aspiration catheter is often blocked by the thrombus, so that the thrombus cannot be aspirated into the aspiration catheter, and the aspiration catheter used alone often cannot aspirate the thrombus into the aspiration catheter or causes too long time for the aspiration operation, thereby causing great risk to a patient.

The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.

Disclosure of Invention

The invention aims to provide an apparatus and a method for sucking thrombus, which are used for slightly moving thrombus blocked at the mouth of a suction catheter by using a suction auxiliary wire when a larger and/or harder thrombus blocks the mouth of the suction catheter, so that negative pressure acting on the suction catheter plays a role, the thrombus can quickly enter the suction catheter and then is sucked out of a human body, and the efficiency and the success rate of thrombus suction surgery are improved.

The purpose of the invention is realized by the following technical scheme:

an apparatus for aspirating thrombus comprising an aspiration catheter device including an aspiration catheter body, an aspiration assist wire hermetically connected with the aspiration catheter body to provide negative pressure to the aspiration catheter body, the aspiration assist wire extending within the aspiration catheter body, the aspiration assist wire being movable along the aspiration catheter body to dislodge thrombus, and a negative pressure aspiration device.

Preferably, the suction assist wire comprises a mandrel and a distal head; the diameter of the mandrel tapers towards the distal head, or the mandrel has a uniform diameter.

Preferably, the distal head of the suction assist wire acts entirely inside the suction catheter body; or the distal end head of the suction auxiliary wire extends out of the distal end outlet of the suction catheter main body for action, and the length of the distal end head of the suction auxiliary wire extending out of the distal end outlet of the suction catheter main body is 0.5mm to 5 mm.

Preferably, the length of the distal head of the suction assist wire is 1mm to 20 mm.

Preferably, the distal tip of the suction assist wire is formed in the shape of a crossed loop, S-shape, drop-shape, spiral, spring-shape, or wave-shape.

Preferably, the distal tip of the suction assist wire is formed of a coiled spring, the free end of which forms an annular shape.

Preferably, the maximum diameter of the distal tip of the suction assist wire is less than the minimum diameter of the suction catheter body.

Preferably, the distal tip of the aspiration-assist wire is coated with a hydrophilic coating and the mandrel of the aspiration-assist wire is coated with a PTFE coating and marked with a length indicator.

Preferably, the suction assisting wire is made of a metal material with good biocompatibility, or the suction assisting wire is made of a composite material composed of a polymer material and a metal material.

Preferably, the distal tip of the suction assist wire is a single wire, or the distal tip of the suction assist wire is composed of a core wire and a winding wire.

Preferably, the distal tip of the aspiration assist wire has elasticity to elastically contact with the thrombus.

Preferably, the distal end portion of the suction catheter body and the distal tip portion of the suction assist wire are each provided with a visualization structure.

Preferably, the suction assist wire can be used in conjunction with a torque device.

Preferably, the suction catheter main body comprises an inner layer, an outer layer and a middle layer, the inner layer and the outer layer are made of polymer materials with good biocompatibility, the middle layer is a woven mesh, and the woven mesh is a metal woven mesh or a composite material woven mesh formed by polymer materials and metal materials.

Preferably, the suction catheter device further comprises a Y-valve integrally assembled with the suction catheter body at a proximal end portion thereof, an anti-folding tube, and a handle, the anti-folding tube and the handle being provided on the suction catheter body at a position near the Y-valve.

Preferably, the Y-valve includes a main tube and a branch tube, the main tube is connected in line with the suction duct main body, the suction auxiliary wire enters the suction duct main body via the main tube, and the negative pressure suction device is in airtight communication with the suction duct main body via the branch tube.

Preferably, the negative pressure suction device comprises a waste liquid collector and a negative pressure generator, and the waste liquid collector is provided with an air inlet and an air outlet.

Preferably, the air inlet of the waste liquid collector is in air-tight communication with the suction duct body through a pressure pipeline, and the air outlet of the waste liquid collector is in air-tight communication with the negative pressure generator.

Preferably, the negative pressure generator is a passive negative pressure generator or an active negative pressure generator.

Preferably, the passive negative pressure generator is a manual negative pressure suction gun, the manual negative pressure suction gun comprises a tubular main body, a suction handle and a negative pressure suction nozzle, an extension part of the suction handle is arranged inside the tubular main body, a negative pressure suction plug is connected to the front end of the extension part of the suction handle, and the negative pressure suction plug is driven to move by pulling a handheld part of the suction handle.

Preferably, the waste liquid collector comprises a bottle body and a cover body for sealing the bottle body, a pressure display meter is arranged on the cover body, the air inlet and the air outlet are arranged on the cover body, the bottle body is made of transparent materials or semitransparent materials, and capacity scales are marked on the outer portion of the bottle body.

Further, the present invention provides a method for aspirating thrombus, which is achieved by the above-mentioned apparatus for aspirating thrombus, comprising the steps of:

pushing the suction catheter main body into the target blood vessel to enable the distal end of the suction catheter main body to be close to the thrombus, and starting to suck the thrombus;

when a large and/or hard thrombus clogs the distal orifice of the suction catheter main body, the suction assist wire is introduced into the distal orifice of the suction catheter main body, and the distal tip of the suction assist wire is used to move the thrombus to reduce the contact area of the thrombus with the distal orifice of the suction catheter main body, thereby allowing the thrombus to be more easily sucked into the suction catheter main body.

The invention has the beneficial effects that:

in the process of a suction embolectomy, large and hard thrombus can be frequently encountered, the mouth of a suction catheter can be blocked by the thrombus, the thrombus can not be sucked into the suction catheter, the suction catheter used alone can often cause that the thrombus can not be sucked into the suction catheter or the time of a suction operation is too long, and thus, great risk can be caused to a patient. When a larger and/or harder thrombus blocks the mouth of the suction catheter, the invention can slightly move the thrombus blocked at the mouth of the suction catheter by using the suction auxiliary wire, so that the negative pressure acting on the suction catheter plays a role, and the thrombus can quickly enter the suction catheter, thereby being sucked out of the human body and improving the efficiency and the success rate of the thrombus suction operation.

The suction catheter is matched with a suction auxiliary wire, so that the suction catheter has the characteristic of high opening rate, and the complications are obviously reduced. The suction auxiliary wire is positioned in the suction catheter, so that the iatrogenic injury to the vessel wall in the thrombus removal process can be effectively reduced. The diameter of the suction auxiliary wire is matched with the suction catheter, the volume is small, the suction catheter does not occupy a suction lumen, and the thrombus suction efficiency and success rate are improved. The suction auxiliary wire is beneficial to trapping thrombus with longer time and expanding thrombus extraction window period. The thrombus extraction technology can not only be used for sucking intracranial thrombus, but also be expanded to the fields of coronary thrombus extraction, peripheral thrombus extraction, pulmonary embolism treatment and the like.

Drawings

Fig. 1 is a schematic structural view of an apparatus for aspirating thrombus according to an embodiment of the present invention.

Fig. 2 is a schematic structural view of an apparatus for aspirating thrombi according to another embodiment of the present invention.

Fig. 3 is a schematic structural view of a portion of an aspiration catheter device according to an embodiment of the invention.

Fig. 4 to 9 are schematic structural views of a suction assist wire according to various embodiments of the present invention.

Fig. 10 is a schematic structural view of a negative pressure suction device with a passive negative pressure generator according to an embodiment of the present invention.

Fig. 11 is a cross-sectional view of the passive negative pressure generator of fig. 10.

Fig. 12 to 14 are schematic views of a process of suctioning a large thrombus by the apparatus for suctioning a thrombus according to the embodiment of the present invention.

Description of reference numerals:

1-a suction catheter body; 2-suction auxiliary thread; 201-a mandrel; 202-a distal head; 3-preventing the pipe from being folded; 4-a handle; a 5-Y valve; 6-a waste liquid collector; 7-a passive negative pressure generator; 8-an active negative pressure generator; 9-a pressure line; 10-a control switch; 11-thrombosis; 601-bottle body; 602-a cover; 603-pressure display meter; 604-an air inlet; 605-gas outlet; 701-a tubular body; 702-a suction handle; 703-pumping a negative pressure nozzle; 704-draw negative pressure plug.

It is to be understood that the appended drawings are not to scale, but are merely drawn with appropriate simplifications to illustrate various features of the basic principles of the invention. Specific design features of the invention disclosed herein, including, for example, specific dimensions, orientations, locations, and configurations, will be determined in part by the particular intended application and use environment. In the several figures of the drawings, identical or equivalent components (elements) are referenced with the same reference numerals.

Detailed Description

The invention is further described below with reference to specific embodiments and the accompanying drawings.

Any of the commercially available embolectomy devices may be used to construct the devices of the present invention. Such instruments include, but are not limited to, the following, for example:

1)Penumbra

is manufactured by Penumbra, inc.

2) The Trevo ProVue embolectomy device, manufactured by Stryker Corporation.

As shown in fig. 1 to 2, an apparatus for aspirating thrombus according to an embodiment of the present invention includes an aspiration catheter device including an aspiration catheter main body 1, an aspiration assist wire 2 airtightly connected to the aspiration catheter main body 1 to supply negative pressure to the aspiration catheter main body 1, and a negative pressure suction device extending inside the aspiration catheter main body 1, the aspiration assist wire 2 being movable along the aspiration catheter main body 1 to move thrombus.

As shown in fig. 1 to 3, according to the embodiment of the present invention, the suction catheter device further includes a Y-valve 5, an anti-folding tube 3, and a handle 4, the Y-valve 5 is connected to a proximal end portion of the suction catheter body 1 to be assembled integrally with the suction catheter body 1, and the anti-folding tube 3 and the handle 4 are provided on the suction catheter body 1 at a position close to the Y-valve 5. In the present embodiment, the Y-valve 5, the handle 4, and the anti-folding tube 3 are disposed in this order at the distal end of the suction catheter main body 1. The Y valve 5 includes a main pipe and a branch pipe, the main pipe is connected to the suction duct main body 1 in a straight line, the suction auxiliary wire 2 enters the suction duct main body 1 via the main pipe, and the negative pressure suction device is in airtight communication with the suction duct main body 1 via the branch pipe.

According to an embodiment of the present invention, the suction catheter body 1 includes an inner layer, an outer layer, and an intermediate layer, the inner layer and the outer layer being made of a high molecular material having good biocompatibility. The inner layer may be an inner PTFE membrane. The outer layer can be a high polymer material with higher hardness, and the hardness of the material of the outer layer can be gradually changed from the near end to the far end. The middle layer is a woven mesh, and the woven mesh is a metal woven mesh or a composite material woven mesh consisting of a high polymer material and a metal material.

As shown in fig. 4 to 9, according to an embodiment of the present invention, the suction assist wire 2 includes a mandrel 201 and a distal head 202; the diameter of the mandrel 201 gradually decreases toward the distal end head 202, and the diameter of the mandrel 201 decreases as the mandrel is closer to the distal end head 202, so that the internal space of the suction catheter main body 1 occupied by the auxiliary wires can be reduced, and thrombus can be more favorably sucked into the suction catheter main body 1. Of course the mandrel 201 may also have a uniform diameter. According to an embodiment of the invention, the distal head 202 of the suction assist wire 2 is coated with a hydrophilic coating and the mandrel 201 of the suction assist wire 2 is coated with a PTFE coating and marked with a length marking.

According to an embodiment of the present invention, the suction assisting wire 2 is made of a metal material having good biocompatibility, or the suction assisting wire 2 is made of a composite material composed of a polymer material and a metal material.

According to an embodiment of the present invention, the distal tip 202 of the suction assist wire 2 is a single wire, or the distal tip 202 of the suction assist wire 2 is composed of a core wire and a winding wire.

The mandrel 201 may be a metal wire, and may be made of a metal material with good biocompatibility, and the metal should have good kink resistance. The wire may have a PTFE coating and the wire may have indicia indicating the length of the suction assist wire 2. The far end of the metal wire can be provided with a metal spring winding structure, so that the flexibility and the softness of the metal wire are improved.

According to an embodiment of the invention, the distal head 202 of the suction assist wire 2 acts entirely inside the suction catheter body 1; alternatively, the distal tip 202 of the suction assisting wire 2 is moved to protrude from the distal outlet of the suction catheter body 1, and the length of the distal tip 202 of the suction assisting wire 2 protruding from the distal outlet of the suction catheter body 1 is 0.5mm to 5 mm.

According to an embodiment of the invention, the length of the distal head 202 of the suction assist wire 2 is 1mm to 20 mm.

As shown in fig. 4 to 8, according to an embodiment of the present invention, the distal tip 202 of the suction assist wire 2 may be formed in a cross-loop shape (as shown in fig. 4), an S-shape (as shown in fig. 7), a drop shape (as shown in fig. 9), a spiral shape (as shown in fig. 6), a spring shape (as shown in fig. 8), or a wave shape (as shown in fig. 5).

As shown in fig. 9, according to the embodiment of the present invention, the distal tip 202 of the suction assist wire 2 is constituted by a coiled spring, and the free end of the coiled spring is formed in an annular shape.

The distal head with the shape can be flexibly contacted with the thrombus, and the integrity of the thrombus cannot be damaged when the thrombus is moved and extruded.

The distal head 202 of the suction assist wire 2 may be a unitary structure or formed from multiple pieces joined by adhesive, laser welding, or mechanical connections.

According to an embodiment of the invention, the maximum diameter of the distal head 202 of the suction assist wire 2 is smaller than the minimum diameter of the suction catheter body 1 to ensure that the suction assist wire 2 can move freely inside the suction catheter body 1.

According to an embodiment of the present invention, the distal head 202 of the aspiration assist wire 2 has elasticity to elastically contact with the thrombus, so that the thrombus can be moved or its morphology can be changed while maintaining its integrity.

According to the embodiment of the present invention, both the distal end portion of the suction catheter main body 1 and the distal tip portion 202 of the suction assist wire 2 are provided with a visualization structure. The positions of the suction catheter body and the suction assist wire, and the relative positions of the two, can be confirmed by visualization.

According to an embodiment of the invention, the aspiration assist wire 2 can be used in conjunction with a torque device that can assist the aspiration assist wire 2 in moving the thrombus.

According to an embodiment of the present invention, the negative pressure suction device includes a waste liquid collector 6 and a negative pressure generator, and the waste liquid collector 6 is provided with an air inlet 604 and an air outlet 605.

According to an embodiment of the invention, the negative pressure generator is a passive negative pressure generator 7 or an active negative pressure generator 8. Shown in fig. 1 is a passive negative pressure generator 7 and shown in fig. 2 is an active negative pressure generator 8.

As shown in fig. 10 to 11, according to the embodiment of the present invention, the passive negative pressure generator 7 is a manual negative pressure suction gun, the manual negative pressure suction gun includes a tubular main body 701, a suction handle 702, and a negative pressure suction nozzle 703, an extension portion of the suction handle 702 is disposed inside the tubular main body 701, a negative pressure suction plug 704 is connected to a front end of the extension portion of the suction handle 702, and the movement of the negative pressure suction plug 704 is driven by pulling a hand-held portion of the suction handle 702. The waste liquid collector 6 comprises a bottle 601 and a cover 602 for closing the bottle 601, a pressure display meter 603 is arranged on the cover 602, the air inlet 604 and the air outlet 605 are arranged on the cover 602, the bottle 601 is made of transparent material or semitransparent material, and the outside of the bottle 601 is marked with volume scales. The air inlet 604 of the waste liquid collector 6 is in air-tight communication with the suction catheter body 1 through a pressure pipeline 9 via a branch pipe of the Y valve 5, a control switch 10 is arranged on the pressure pipeline 9, and the air outlet 605 of the waste liquid collector 6 is in air-tight communication with a manual negative pressure suction gun (the two can be connected through the pressure pipeline 9).

The outlet 605 of the waste liquid collector 6 comprises a movable air lock, by which a non-return means is formed. The inlet 604 of the waste collector 6 is formed as a male luer connector or as a tapered opening. The pressure pipeline 9 is composed of a pipeline made of TPU with a woven mesh, or a pipeline made of TPU without a woven mesh, or a pipeline made of PVC. One or both of the head ends of the pressure pipeline 9 are provided with luer connector female heads or both of the head ends are tapered interfaces.

Before use, a negative pressure is generated in advance for the waste liquid collector 6 through the pressure line 9 by the negative pressure generator (in this embodiment, a manual negative pressure suction gun), and the waste liquid collector 6 can maintain the negative pressure by forming an airtight space through the pressure line 9 and the control switch 10, thereby preparing for suction of the thrombus. The negative pressure range can be-70 Kpa-100 Kpa, and the volume of the waste liquid collector 6 can be 800ml-1500 ml.

When the apparatus for sucking thrombus is used, an operator needs to select a proper guide wire according to the lesion position of a patient, and the guide wire and the support catheter are matched and sent to the lesion position; the suction catheter body 1 is guided by the guide wire to reach the lesion position, the distal end of the suction catheter body 1 is flush with the blocked thrombus, the guide wire is withdrawn at the moment, and if the thrombus is general, the thrombus can be directly sucked into the suction catheter body 1 by the negative pressure provided by the negative pressure suction device and further enters the waste liquid collector 6.

As shown in fig. 12 to 14, when a large and/or hard thrombus 11 is encountered, such thrombus 11 is likely to block the orifice of the suction catheter main body 1, so that negative pressure cannot work, and the thrombus 11 cannot be directly sucked into the suction catheter but blocks the orifice (as shown in fig. 12), so that problems that the thrombus 11 cannot be sucked or the suction operation time is too long are encountered, which causes a great risk to the patient. The embodiment according to the present invention provides the suction assist wire 2 to solve the above-described problems. The Y valve 5 is connected to the near end of the suction catheter main body 1, the suction auxiliary wire 2 penetrates into the suction catheter main body 1 from the main pipe of the Y valve 5, the Y valve 5 is screwed to a certain degree of tightness, the negative pressure suction device is made to have a certain negative pressure in advance through the negative pressure generator, the negative pressure suction device is connected to the branch pipe of the Y valve 5 through the pressure pipeline 9 and the control switch 10 to form an airtight passage, the control switch 10 is opened to start suction on the thrombus 11, and simultaneously the thrombus 11 blocked at the pipe orifice of the suction catheter main body 1 is moved and extruded by using the suction auxiliary wire 2 (as shown in figure 13) to play a role of auxiliary suction. As shown in FIG. 14, the dislodged and squeezed thrombus 11 can be quickly sucked into the interior of the suction catheter main body 1 without clogging the nozzle, improving the suction efficiency.

In the process of a suction embolectomy, large and hard thrombus can be frequently encountered, the mouth of a suction catheter can be blocked by the thrombus, the thrombus can not be sucked into the suction catheter, the suction catheter used alone can often cause that the thrombus can not be sucked into the suction catheter or the time of a suction operation is too long, and thus, great risk can be caused to a patient. According to the invention, when a larger and/or harder thrombus blocks the mouth of the suction catheter, the thrombus blocked at the mouth of the suction catheter is slightly moved and extruded by using the suction auxiliary wire 2, so that the contact area between the thrombus and the distal end mouth of the suction catheter main body 1 is reduced, the negative pressure acting on the suction catheter plays a role, and further the thrombus can quickly enter the suction catheter, so that the thrombus is sucked out of a human body, and the efficiency and success rate of thrombus suction surgery are improved.

Herein, "proximal" refers to the end closer to the operator, and "distal" refers to the end farther from the operator.

The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. The foregoing description is not intended to be exhaustive or to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable others skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications thereof.

Claims

1. An apparatus for aspiration of thrombus comprising an aspiration catheter device including an aspiration catheter body, an aspiration assist wire hermetically connected with the aspiration catheter body to provide negative pressure to the aspiration catheter body, and a negative pressure aspiration device extending within the aspiration catheter body, the aspiration assist wire being movable along the aspiration catheter body to dislodge thrombus.

2. An apparatus for aspirating thrombus according to claim 1 wherein said aspiration assist wire comprises a mandrel and a distal head; the diameter of the mandrel tapers towards the distal head, or the mandrel has a uniform diameter.

3. An apparatus for aspirating thrombus according to claim 2, wherein the distal head of said aspiration assist wire acts entirely inside said aspiration catheter body; or the distal end head of the suction auxiliary wire extends out of the distal end outlet of the suction catheter main body for action, and the length of the distal end head of the suction auxiliary wire extending out of the distal end outlet of the suction catheter main body is 0.5mm to 5 mm.

4. An apparatus for aspirating thrombus according to claim 2, wherein the distal head of said aspiration assist wire has a length of 1mm to 20 mm.

5. An instrument for aspirating thrombus according to claim 2, wherein the distal tip portion of said aspiration assist wire is formed in the shape of a crossed loop, S-shape, drop-shape, spiral, spring-shape or wave-shape.

6. An apparatus for aspirating thrombus according to claim 2, wherein the distal tip of said aspiration assist wire is constituted by a coiled spring, the free end of which is formed into an annular shape.

7. An apparatus for aspirating thrombus according to claim 2 wherein the maximum diameter of the distal tip of said aspiration assist wire is less than the minimum diameter of said aspiration catheter body.

8. An apparatus for aspirating thrombus according to claim 2 wherein the distal tip of said aspiration assist wire is coated with a hydrophilic coating and the mandrel of said aspiration assist wire is coated with a PTFE coating and marked with a length indicator.

9. An apparatus for aspirating thrombus according to claim 2, wherein said aspiration assist wire is made of a biocompatible metallic material or is made of a composite material composed of a polymeric material and a metallic material.

10. An apparatus for aspirating thrombus according to claim 2, wherein the distal tip of said aspiration assist wire is a single wire or is composed of a core wire and a winding wire.

11. An apparatus for aspirating thrombus according to any of claims 2-10 wherein the distal tip of said aspiration assist wire has elasticity to elastically contact the thrombus.

12. An apparatus for aspirating thrombus according to claim 2, wherein both the distal end portion of said aspiration catheter main body and the distal tip portion of said aspiration assist wire are provided with visualization structures.

13. An apparatus for aspirating thrombus according to claim 1 wherein said aspiration assist wire is adapted to cooperate with a torque device.

14. The apparatus for aspirating thrombus of claim 1, wherein the aspiration catheter body comprises an inner layer, an outer layer and a middle layer, the inner layer and the outer layer are made of polymer materials with good biocompatibility, the middle layer is a woven mesh, and the woven mesh is a woven mesh made of metal materials or a composite material consisting of polymer materials and metal materials.

15. The apparatus for aspirating thrombus of claim 1, wherein said aspiration catheter device further comprises a Y-valve, an anti-kink tube and a handle, said Y-valve being integrally assembled with said aspiration catheter body at a proximal end portion thereof, said anti-kink tube and said handle being disposed on said aspiration catheter body at a position close to said Y-valve.

16. The apparatus for suctioning thrombus according to claim 15, wherein the Y-valve comprises a main tube and a branch tube, the main tube is connected in line with the suction catheter main body, the suction assist wire enters the suction catheter main body via the main tube, and the negative pressure suction device is in airtight communication with the suction catheter main body via the branch tube.

17. An apparatus for aspirating thrombus according to claim 16 wherein said negative pressure suction means comprises a waste liquid collector provided with an air inlet and an air outlet and a negative pressure generator.

18. The apparatus for aspirating thrombus of claim 17, wherein the air inlet of the waste liquid collector is in air-tight communication with the aspiration catheter body through a pressure line, and the air outlet of the waste liquid collector is in air-tight communication with the negative pressure generator.

19. An apparatus for aspirating thrombus according to claim 18 wherein said negative pressure generator is a passive or active negative pressure generator.

20. The apparatus for aspirating thrombus of claim 19, wherein said passive negative pressure generator is a manual negative pressure suction gun comprising a tubular body, a suction handle and a negative pressure suction nozzle, an extension of said suction handle is disposed inside said tubular body, a negative pressure suction plug is connected to a front end of said extension of said suction handle, and a movement of said negative pressure suction plug is driven by pulling a hand-held portion of said suction handle.

21. The apparatus for suctioning thrombus according to claim 20, wherein the waste liquid collector comprises a bottle body and a cover body for closing the bottle body, a pressure display gauge is disposed on the cover body, the air inlet and the air outlet are disposed on the cover body, the bottle body is made of a transparent material or a translucent material, and a volume scale is marked on the outside of the bottle body.

22. A method for aspirating thrombus by the apparatus for aspirating thrombus of any one of claims 1-20, comprising the steps of: