CN111887826A - Fluorescent camera based on indocyanine green and application thereof - Google Patents
Fluorescent camera based on indocyanine green and application thereof Download PDFInfo
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- CN111887826A CN111887826A CN202010795967.9A CN202010795967A CN111887826A CN 111887826 A CN111887826 A CN 111887826A CN 202010795967 A CN202010795967 A CN 202010795967A CN 111887826 A CN111887826 A CN 111887826A
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- imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
Abstract
The invention discloses a fluorescent camera based on indocyanine green and application thereof, wherein the fluorescent camera comprises: the light source emitting module can emit near-infrared light with the wavelength of 750nm-810nm, a low-coherence light source of the near-infrared light is utilized to irradiate a region to be scanned of an imaging target, and indocyanine green molecules in the imaging target are excited to generate fluorescence; the fluorescence information acquisition module is used for collecting and analyzing the fluorescence signals; an imaging module that converts the fluorescence signal into a vascular image of an imaging target organ; the display module displays the blood vessel imaging on a screen; the image output module outputs the picture of the blood vessel imaging through a USB output port or directly through a printing device; and the battery module is used for providing electric energy for each module. The fluorescence camera is mainly used for collecting, observing and evaluating the blood vessel condition in and after a target organ operation, and has the advantages of simple operation, convenient carrying, high imaging speed, good imaging effect and the like.
Description
Technical Field
The invention belongs to the technical field of fluorescence imaging, and particularly relates to a fluorescence camera based on indocyanine green and application thereof.
Background
The OCT technology utilizes the basic principle of weak coherent light interference to detect back reflection or several scattering signals of different depth layers of biological tissues to incident weak coherent light, and can obtain depth signals of the biological tissues by scanning and reconstruct two-dimensional or three-dimensional structural images so as to obtain depth information of organisms. The fluorescence imaging technology uses a fluorescence probe to excite the probe by an excitation light source to generate a fluorescence signal and collects the fluorescence signal.
Various endogenous chromophores (such as deoxyhemoglobin, oxyhemoglobin, melanin, lipids) can be used as optical imaging contrast agents, which allows us to study brain function and tumor microcirculation. However, in most cases, specific biomolecules that reflect physiological changes in the disease do not produce an effective signal upon laser excitation; the use of exogenous optical probes to enhance the signal such that specific biomolecules associated with a disease but "invisible" are detected will aid in the detection and treatment of such diseases. Currently, indocyanine green (ICG) is widely used in angiography, which is a great help for diagnosis and treatment of diseases. Compared with other contrast methods (X-ray, CT, MRI, PET, etc.), ICG can be widely applied to the imaging radiography of the operation conveniently and with reduced economic cost.
Currently, imaging for ICG is typically accomplished using relatively complex fluorescence imaging equipment. A surgical visualization and medical imaging device and method using near-infrared fluorescent polymers is disclosed in the invention application No. 201880026010.9, which uses indocyanine green dye in combination with plastic and is used in enhanced surgical imaging applications, such as robot-assisted surgery. A near infrared light source, such as a 805nm laser, may be used to excite the surgical device, causing the device to emit 835nm light. Both excitation and emission wavelengths penetrate tissue and blood and provide enhanced surgical imaging. The resulting fluoroscopic image enables the user to easily determine relative tissue depth, identify tissue inhomogeneities, detect bumps or tissue irregularities, pinpoint anatomical holes, and visualize breaches.
As another example, application No. 201811641552.5 discloses a fluorescent-OCT dual-mode imaging method and an imaging device based on a green indocyanine nano-material, wherein the imaging method includes combining the green indocyanine material with a phospholipid polyethylene glycol to form a nano indocyanine material, and modifying a biological targeting molecule at the end of the polyethylene glycol molecule to obtain an ICG-PL-PEG-FA solution as a contrast agent of the fluorescent-OCT dual-mode imaging system; injecting the ICG-PL-PEG-FA solution into an imaging target, irradiating a region to be scanned of the imaging target with a low-coherence light source of near infrared light and exciting ICG-PL-PEG-FA molecules within the imaging target using a light source of 780nm wavelength to generate fluorescence; and opening an OCT imaging optical path to acquire an OCT imaging structural image with a depth range of the imaging target. The imaging device comprises a solution preparation module, a biological targeting molecule and a fluorescence-OCT dual-mode imaging system, wherein the solution preparation module is used for combining indocyanine green and phosphatided polyethylene glycol to form indocyanine green nano particles, and modifying the tail end of polyethylene glycol molecules with the biological targeting molecule to finally obtain an ICG-PL-PEG-FA solution as a contrast agent of the fluorescence-OCT dual-mode imaging system; a light source module for injecting the ICG-PL-PEG-FA solution to an imaging target, irradiating a region to be scanned of the imaging target with a low-coherence light source of near infrared light and exciting ICG-PL-PEG-FA molecules within the imaging target using a light source of 780nm wavelength to generate fluorescence; and the imaging module is used for opening an OCT imaging optical path to acquire a structural image with a depth range formed by OCT imaging of the imaging target.
In the above prior art, angiography is performed by using fluorescence reaction of indocyanine green, but the apparatus is generally complicated and inconvenient to carry and use.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a fluorescent camera based on indocyanine green and application thereof, which can be widely used for collecting, observing and evaluating the blood vessel condition in and after a target organ operation, and have the advantages of simple operation, convenience in carrying, high imaging speed, good imaging effect and the like.
The technical scheme adopted by the invention for solving the technical problem is as follows: a fluorescent camera based on indocyanine green, the fluorescent camera essentially comprising: the device comprises a light source emitting module, a fluorescence information acquisition module, an imaging module, a display module and an image output module; wherein the content of the first and second substances,
the light source emission module can emit near-infrared light with the wavelength of 750nm-810nm, irradiate the area to be scanned of the imaging target by using a low-coherence light source of the near-infrared light, and excite indocyanine green molecules in the imaging target by using the near-infrared light source to generate fluorescence;
the fluorescence information acquisition module is used for collecting and analyzing fluorescence signals generated by indocyanine green molecules in the imaging target;
the imaging module is used for converting the fluorescence signals acquired by the fluorescence information acquisition module into blood vessel imaging of an imaging target organ;
the display module displays the blood vessel image converted by the imaging module on a screen for a user to watch in real time;
the image output module outputs the picture of the blood vessel imaging through a USB output port or directly through a printing device;
the battery module is used for providing electric energy for other modules in the fluorescent camera;
the light source emitting module, the fluorescence information acquisition module, the imaging module, the display module, the image output module and the battery module are all integrated in the fluorescence camera, and the fluorescence camera can be carried about for use.
Further, the indocyanine green is diluted according to a certain proportion, an imaging target is achieved in an intravenous injection mode, and imaging can be achieved through a fluorescence camera 3-5 minutes after injection.
Further, the indocyanine green is dissolved by using sterilized water for injection, and the solubility after dilution is 2.5 mg/ml; the injection dosage of the indocyanine green diluent is 0.1-0.5mg/Kg, the dosage is calculated according to the body weight of an examiner, and the medicine needs to be prepared for use.
Further, the wavelength of the near-infrared light emitted by the light source emission module is 780 nm.
Further, the imaging method of the fluorescence camera is that the diluted indocyanine green solution is injected into the vein of a patient, and the injection is waited for 3-5 minutes; emitting near infrared light by using a light source emitting module in the fluorescence camera, irradiating a band scanning area of an imaging target and exciting indocyanine green molecules in the imaging target by using the near infrared light of 750nm-810nm to generate fluorescence; the generated fluorescence signal is collected and analyzed by a fluorescence information acquisition module; converting the blood vessel imaging of the imaging target organ through an imaging module; the display module is used for displaying the information on a screen for a user to check in real time; the image of the blood vessel is output through a USB output port or directly through a printing device, and a user carries out medical evaluation and diagnosis on a patient through the output image.
The application of a fluorescent camera based on indocyanine green is mainly used for collecting, observing and evaluating blood vessel conditions in and after target organ operations, and comprises blood supply conditions at two ends of a gastrointestinal anastomosis, blood vessel evaluation in and after amputation replantation, blood vessel evaluation of target organ tumors, sentinel lymph node imaging and in-vitro lymph node picking imaging.
The invention has the beneficial effects that: compared with the prior art, the fluorescent camera based on indocyanine green and the application thereof can be widely used for collecting, observing and evaluating the blood vessel condition in and after the target organ operation, and have the advantages of simple operation, convenient carrying, high imaging speed, good imaging effect and the like.
Drawings
Fig. 1 is a block diagram showing the structure of a fluorescence camera according to the present invention.
Wherein, 1-battery module; 2-a light source emitting module; 3-a fluorescence information acquisition module; 4-an imaging module; 5-a display module; 6-image output module.
Detailed Description
The invention is further illustrated by the following specific examples. These examples are intended to illustrate the invention and are not intended to limit the scope of the invention.
As shown in fig. 1, a fluorescence camera based on indocyanine green mainly comprises: the system comprises a light source emitting module 2, a fluorescence information acquisition module 3, an imaging module 4, a display module 5 and an image output module 6; the light source emitting module 2 can emit near-infrared light with the wavelength of 780nm, irradiate the area to be scanned of the imaging target by using a low-coherence light source of the near-infrared light, and excite indocyanine green molecules in the imaging target by using the near-infrared light source to generate fluorescence; the fluorescence information acquisition module 3 is used for collecting and analyzing fluorescence signals generated by indocyanine green molecules in the imaging target; the imaging module 4 is used for converting the fluorescence signals acquired by the fluorescence information acquisition module 3 into blood vessel imaging of an imaging target organ; the display module 5 displays the blood vessel image converted by the imaging module 4 on a screen for a user to watch in real time; the image output module 6 outputs the picture of the blood vessel imaging through a USB output port or directly through a printing device; the battery module 1 is used for providing electric energy for other modules in the fluorescent camera; the light source emitting module 2, the fluorescence information collecting module 3, the imaging module 4, the display module 5, the image output module 6 and the battery module 1 are all integrated in a fluorescence camera, and the fluorescence camera can be carried about for use.
The indocyanine green is diluted according to a certain proportion, an imaging target is achieved in an intravenous injection mode, and imaging can be achieved through a fluorescence camera 3-5 minutes after injection.
Dissolving indocyanine green by using sterile water for injection, wherein the solubility of the diluted indocyanine green is 2.5 mg/ml; the injection dosage of the indocyanine green diluent is 0.1-0.5mg/Kg, the dosage is calculated according to the body weight of an examiner, and the medicine needs to be prepared for use. Need to fast before the inspection, band and drink more than 4 hours, stop intravenous administration more than 1 hour, inquire whether have iodine allergy history, prepare salvage drugs such as antiallergic medicine, choose arm vein puncture injection for use, the scalp acupuncture more than 7 is pushed with normal saline earlier, it injects right amount of dilution indocyanine green fast to prove that the vein does not have after the external leakage, within 10s, later reuse normal saline wash the pipe, observe the reaction of inspection simultaneously.
The imaging method of the fluorescence camera comprises the steps of firstly injecting diluted indocyanine green solution into the vein of a patient, and waiting for 3-5 minutes after injection; emitting near infrared light by using a light source emission module 2 in a fluorescence camera, irradiating a band scanning area of an imaging target and exciting indocyanine green molecules in the imaging target by using 780nm near infrared light to generate fluorescence; the generated fluorescence signal is collected and analyzed by a fluorescence information collecting module 3; converting the blood vessel imaging of the imaging target organ through the imaging module 4; and the data is displayed on a screen through a display module 5 for a user to check in real time; the image of the blood vessel is output through a USB output port or directly through a printing device, and a user carries out medical evaluation and diagnosis on a patient through the output image.
The application of a fluorescent camera based on indocyanine green is mainly used for collecting, observing and evaluating blood vessel conditions in and after target organ operations, and comprises blood supply conditions at two ends of a gastrointestinal anastomosis, blood vessel evaluation in and after amputation replantation, blood vessel evaluation of target organ tumors, blood vessel integrity evaluation, diagnosis evaluation of vascular embolic diseases such as venous thrombosis and the like, sentinel lymph node imaging and in-vitro lymph node picking imaging.
The fluorescence camera provided by the invention realizes the tracing of the blood flow condition through indocyanine green, so that the observation target blood vessel is visualized. For example, the evaluation of blood supply conditions at two ends of an anastomotic stoma of a gastrointestinal tract, anastomotic leakage is a common complication after gastrointestinal tract resection, and anastomotic leakage is an important reason causing anastomotic leakage, so that the evaluation of blood supply of anastomotic stoma is important in the operation, at present, the evaluation mainly depends on the experience of an operator to judge, including the color of the gastrointestinal tract tube wall before and after anastomosis, the bleeding condition of the broken end of the anastomotic site, whether the pulsation of an artery exists, and the like, and lacks objective basis, but by using the fluorescence camera provided by the invention, the blood vessels at two ends of the anastomotic stoma can be evaluated respectively before and after gastrointestinal tract anastomosis is completed, a pre-excision line is selected and marked through clinical judgment before cutting off the intestinal tract, indocyanine green is injected intravenously, the image of the fluorescence camera is used, the blood vessel condition is evaluated according to the blood vessel image, the boundary of the perfusion tissue and the non-perfusion, after the anastomotic stoma is finished, intravenous injection is carried out again, images of the fluorescence camera are used, and blood supply at two ends of the anastomotic stoma is evaluated again, so that good blood supply of the anastomotic stoma is ensured, and anastomotic leakage is reduced. The fluorescence camera provided by the invention can provide objective blood vessel images as a basis and provide powerful help for clinic.
The above embodiments are only for illustrating the invention and are not to be construed as limiting the invention, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention, therefore, all equivalent technical solutions also belong to the scope of the invention, and the scope of the invention is defined by the claims.
Claims (6)
1. A fluorescence camera based on indocyanine green, characterized in that it essentially comprises: the device comprises a light source emitting module, a fluorescence information acquisition module, an imaging module, a display module and an image output module; wherein the content of the first and second substances,
the light source emission module can emit near-infrared light with the wavelength of 750nm-810nm, irradiate a region to be scanned of an imaging target by using a low-coherence light source of the near-infrared light, and excite indocyanine green molecules in the imaging target by using the near-infrared light source to generate fluorescence;
the fluorescence information acquisition module is used for collecting and analyzing fluorescence signals generated by indocyanine green molecules in the imaging target;
the imaging module is used for converting the fluorescence signals acquired by the fluorescence information acquisition module into blood vessel imaging of an imaging target organ;
the display module displays the blood vessel image converted by the imaging module on a screen for a user to watch in real time;
the image output module outputs the picture of the blood vessel imaging through a USB output port or directly through a printing device;
the battery module is used for providing electric energy for other modules in the fluorescent camera;
the light source emitting module, the fluorescence information acquisition module, the imaging module, the display module, the image output module and the battery module are all integrated in the fluorescence camera, and the fluorescence camera can be carried about for use.
2. A fluorescent camera based on indocyanine green as claimed in claim 1, characterized in that: the indocyanine green is diluted according to a certain proportion, an imaging target is achieved in an intravenous injection mode, and imaging can be achieved through a fluorescence camera 3-5 minutes after injection.
3. A fluorescent camera based on indocyanine green as claimed in claim 1, characterized in that: dissolving indocyanine green by using sterile water for injection, wherein the solubility of the diluted indocyanine green is 2.5 mg/ml; the injection dosage of the indocyanine green diluent is 0.1-0.5mg/Kg, the dosage is calculated according to the body weight of an examiner, and the medicine needs to be prepared for use.
4. A fluorescent camera based on indocyanine green as claimed in claim 1, characterized in that: the wavelength of the near-infrared light emitted by the light source emission module is 780 nm.
5. A fluorescent camera based on indocyanine green as claimed in any one of claims 1 to 4, characterized in that: the imaging method of the fluorescence camera comprises the steps of firstly injecting diluted indocyanine green solution into the vein of a patient, and waiting for 3-5 minutes after injection; emitting near infrared light by using a light source emitting module in the fluorescence camera, irradiating a band scanning area of an imaging target and exciting indocyanine green molecules in the imaging target by using the near infrared light of 750nm-810nm to generate fluorescence; the generated fluorescence signal is collected and analyzed by a fluorescence information acquisition module; converting the blood vessel imaging of the imaging target organ through an imaging module; the display module is used for displaying the information on a screen for a user to check in real time; the image of the blood vessel is output through a USB output port or directly through a printing device, and a user carries out medical evaluation and diagnosis on a patient through the output image.
6. Use of a fluorescent camera based on indocyanine green according to any one of claims 1 to 4, characterized in that: the fluorescence camera can be mainly used for collecting, observing and evaluating the blood vessel conditions in and after target organ operation, including blood supply conditions at two ends of a gastrointestinal anastomosis stoma, blood vessel evaluation in and after amputation replantation, blood vessel evaluation of target organ tumor, sentinel lymph node imaging and in-vitro lymph node retrieval imaging.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010795967.9A CN111887826A (en) | 2020-08-10 | 2020-08-10 | Fluorescent camera based on indocyanine green and application thereof |
| PCT/CN2021/099249 WO2022033151A1 (en) | 2020-08-10 | 2021-06-09 | Fluorescent camera based on indocyanine green, and use thereof |
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| CN202010795967.9A CN111887826A (en) | 2020-08-10 | 2020-08-10 | Fluorescent camera based on indocyanine green and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022033151A1 (en) * | 2020-08-10 | 2022-02-17 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green, and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102319059B (en) * | 2011-10-28 | 2013-03-27 | 北京天助基业科技发展有限公司 | Near-infrared fluorescence imaging surgery guide device and application thereof |
| CN104623695B (en) * | 2015-03-05 | 2016-01-06 | 王永胜 | Indocyanine green-Rituximab is preparing the application of sentinel lymph nodes of breast cancer tracer |
| WO2018144785A1 (en) * | 2017-02-02 | 2018-08-09 | The Regents Of The University Of California | Fluorescence imaging processing and computation for surgery |
| CN110582222B (en) * | 2017-02-18 | 2022-06-21 | 罗切斯特大学 | Surgical visualization and medical imaging devices and methods using near infrared fluorescent polymers |
| CN109799216B (en) * | 2018-12-29 | 2021-11-12 | 佛山科学技术学院 | Fluorescence OCT dual-mode imaging method and device based on green nano indocyanine |
| CN212913171U (en) * | 2020-08-10 | 2021-04-09 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green |
| CN111887826A (en) * | 2020-08-10 | 2020-11-06 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green and application thereof |
| CN111887817A (en) * | 2020-08-27 | 2020-11-06 | 复旦大学附属中山医院 | Method for developing hepatic portal vein drainage basin by combining indocyanine green fluorescence with multi-modal image guidance |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022033151A1 (en) * | 2020-08-10 | 2022-02-17 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green, and use thereof |
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Application publication date: 20201106 |